Parvalbumin Interneurons Shape Neuronal Vulnerability in Blunt TBI

Abstract

Excessive excitation has been hypothesized to subsume a significant part of the acute damage occurring after traumatic brain injury (TBI). However, reduced neuronal excitability, loss of neuronal firing, and a disturbed excitation/inhibition balance have been detected. Parvalbumin (PV) interneurons are major regulators of perisomatic inhibition, principal neurons firing, and overall cortical excitability. However, their role in acute TBI pathogenic cascades is unclear. We exploited the chemogenetic Pharmacologically Selective Activation Module and Pharmacologically Selective Effector Module control of PV-Cre⁺ neurons and the Designer Receptors Exclusively Activated by Designer Drug (DREADD) control of principal neurons in a blunt model of TBI to explore the role of inhibition in shaping neuronal vulnerability to TBI. We demonstrated that inactivation of PV interneurons at the instance or soon after trauma enhances survival of principal neurons and reduces gliosis at 7 dpi whereas, activation of PV interneurons decreased neuronal survival. The protective effect of PV inactivation was suppressed by expressing the nuclear calcium buffer PV-nuclear localisation sequence in principal neurons, implying an activity-dependent neuroprotective signal. In fact, protective effects were obtained by increasing the excitability of principal neurons directly using DREADDs. Thus, we show that sustaining neuronal excitation in the early phases of TBI may reduce neuronal vulnerability by increasing activity-dependent survival, while excess activation of perisomatic inhibition is detrimental to neuronal integrity.

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Spreading of Tau Pathology in Sporadic Alzheimer’s Disease Along Cortico-cortical Top-Down Connections

Abstract

By using AT8-immunocytochemistry that visualizes hyperphosphorylated tau protein, we examined neurofibrillary changes related to sporadic Alzheimer's disease (AD) in N = 40 individuals at neurofibrillary tangle (NFT) stages I–IV. We report the presence of abnormal tau changes within solitary pyramidal neurons in layers III and V of the neocortex. These pyramidal cells showed pathology in different cell compartments (dendritic, somatic, axonal) that appeared to occur sequentially: Tau pathology was seen in distal segments of the basal dendrites, then in proximal dendrites, the soma, and, finally, in the axon of affected neurons. These findings are remarkable in that they point to the existence of neurofibrillary changes in regions routinely associated with later NFT stages. In addition, they lend support to the idea that it may be the axons of cortico-cortical top-down neurons in neocortical fields involved in AD that carry and spread abnormal tau seeds in a focused manner (transsynaptically) into the distal dendritic segments of nerve cells following directly in the neuronal chain, thereby sustaining further tau-seeded templating.

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Effects of perineural invasion in prostate needle biopsy on tumor grade and biochemical recurrence rates after radical prostatectomy

Publication date: July 2018
Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7
Author(s): Serdar Celik, Ozan Bozkurt, Omer Demir, Ozgur Gurboga, Burcin Tuna, Kutsal Yorukoglu, Guven Aslan
To predict local invasive disease before retropubic radical prostatectomy (RRP), the correlation of perineural invasion (PNI) on prostate needle biopsy (PNB) and RRP pathology data and the effect of PNI on biochemical recurrence (BR) were researched. For patients with RRP performed between 2005 and 2014, predictive and pathologic prognostic factors were assessed. Initially all and D'Amico intermediate-risk group patients were comparatively assessed in terms of being T2 or T3 stage on RRP pathology, positive or negative for PNI presence on PNB and positive or negative BR situation. Additionally the effect of PNI presence on recurrence-free survival (RFS) rate was investigated. When all patients are investigated, multivariate analysis observed that in T3 patients PSA, PNB Gleason score (GS) and tumor percentage were significantly higher; in PNI positive patients PNB GS, core number and tumor percentage were significantly higher and in BR positive patients PNB PNI positivity and core number were significantly higher compared to T2, PNI negative and BR negative patients, separately (p < 0.05). When D'Amico intermediate-risk patients are evaluated, for T3 patients PSA and PNB tumor percentage; for PNI positive patients PNB core number and tumor percentage; and for BR positive patients PNB PNI positivity were significantly higher compared to T2, PNI negative and BR negative patients, separately (p < 0.05). Mean RFS in the whole patient group was 56.4 ± 4.2 months for PNI positive and 96.1 ± 5.7 months for negative groups. In the intermediate-risk group, mean RFS was 53.7 ± 5.1 months for PNI positive and 100.3 ± 7.7 months for negative groups (p < 0.001). PNI positivity on PNB was shown to be an important predictive factor for increased T3 disease and BR rates and reduced RFS.



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Simplified scoring system for prediction of mortality in acute suppurative cholangitis

Publication date: July 2018
Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7
Author(s): Barış Doğu Yıldız, Sabri Özden, Barış Saylam, Fahri Martlı, Mesut Tez
Our objective in this study was to identify the factors contributing to mortality in acute suppurative cholangitis which could be tested easily in every emergency clinic. This is a retrospective study enrolling 104 patients with acute suppurative cholangitis. Demographic and laboratory data were collected for analysis. In univariant analysis red cell distribution width, total bilirubin level, intensive care unit admission was identified as statistically significant (p < 0.05) to predict mortality. Three variables were statistically significant in multivariate analysis: total bilirubin level equal to or more than 6.9 mg/dl, red cell distribution width equal to or more than 14.45%, and admission to intensive care unit. We found a new scoring system for prediction of mortality in acute suppurative cholangitis utilizing only three variables. This would serve as a simplified, rapid way to direct patients for advanced interventions instead of wasting time with more complicated and time consuming multi-variable scoring systems.



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Influence of tidal volume on ventilation distribution and oxygenation during one-lung ventilation

Publication date: July 2018
Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7
Author(s): Wei Wang, Mei-Ying Xu, Jing-Xiang Wu, Zhan-Qi Zhao




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Effectiveness of robo-assisted lower limb rehabilitation for spastic patients: A systematic review

Publication date: 15 October 2018
Source:Biosensors and Bioelectronics, Volume 117
Author(s): Divya Shakti, Lini Mathew, Neelesh Kumar, Chitra Kataria
BackgroundThough many rehabilitative treatments are available for treatment of spasticity, thus the effectiveness of different robo-rehabilitative devices needs to be evaluated through a systematic review.ObjectiveThe objective of this study is to focuses on the efficacy of Robot assistive rehabilitation device for the removal of spasticity from the lower limb of Spastic patients.Data SourcessourcesPubMed, Web of Sciences, EMBASE (Excerpta Medical database), CDSR (Cochrane database of systematic reviews), Scopus, IEEE Xplore, Wiley online library, MEDLINE (OvidSP), Science Direct, Springer Link were from January 1980 to September 2017Data ExtractionextractionSeventy-one publications from eleven databases published were selected using keywords Ankle foot, spasticity, robotic rehabilitation, efficacy of robotics and Ankle foot rehabilitation. The review is narrowed down to twenty-six articles which were selected for they focused on effects of Robot assistive rehabilitation device quantitatively.ResultA quantitative study from analyzing 26 studies comprising of 786 subjects is carried out. The major outcome of the effectiveness of the robot assistive therapy for the movement of ankle and functioning of gait is deduced. As the used protocols and treatment procedures vary, made comparative study complex or impracticable.ConclusionRobo-rehabilitation possesses an ability to provide unified therapy protocols with greater ease in comparison to conventional therapies. They continuously prove to be irreplaceable assistant devices when it comes to providing excellent treatment in terms of improvement from this study. Though many mechatronic devices are available but the devices for treatment of early stage rehabilitation of stroke patients is very limited.



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A DNA nanostructured aptasensor for the sensitive electrochemical detection of HepG2 cells based on multibranched hybridization chain reaction amplification strategy

Publication date: 15 October 2018
Source:Biosensors and Bioelectronics, Volume 117
Author(s): Dabin Chen, Duanping Sun, Zhiru Wang, Weiwei Qin, Liang Chen, Ledu Zhou, Yuanqing Zhang
Sensitive detection of cancer cells is beneficial to the early diagnosis of cancer and individual treatment. In the present study, a DNA nanostructured aptasensor was used for the sensitive electrochemical detection of human liver hepatocellular carcinoma cells (HepG2) based on multibranched hybridization chain reaction amplification strategy. We established a well-designed platform by immobilizing DNA tetrahedron, a three-dimensional DNA nanostructure, on the gold electrode to capture HepG2 cells more specifically and efficiently. Meanwhile, functional hybrid nanoprobes consisted of MIL-101@AuNPs (Au nanoparticles), numerous hemin/G-quadruplex DNAzyme from multibranched hybridization chain reaction, and natural horseradish peroxidase (HRP) was designed. The hybrid nanoprobes possessed the functions of specific discernment and enzymatic signal amplification simultaneously. With the help of nanoprobes, HepG2 cells were recognized and captured to form a DNA tetrahedron-cell-nanoprobe sandwich-like structure on the electrode surface. The lower detection limit of this established cytosensor is 5 cells per ml. Moreover, it delivered a broad detection range from 10² to 10⁷ cells per ml. The results revealed that the as-proposed cytosensor may be utilized as a powerful tool for early diagnosis of cancer in the future.



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An approach to the heating dynamics of residues from greenhouse-crop plant biomass originated by tomatoes ( Solanum lycopersicum , L.)

Abstract

The most representative of greenhouse-crop plant biomass residues of tomatoes (Solanum lycopersicum L.) were selected for this study by using X-ray fluorescence spectrometry (XRF) and X-ray powder diffraction (XRD). The heating dynamics in air in the 600–1150 °C range of these residues for the production of renewable energy and the resultant ashes have been investigated. A total of 11 elements were determined by XRF in the biomass ashes and some minor elements. The content of alkaline elements and chlorides decreased as increasing heating temperature and disappeared at 1150 °C. Alkaline salts, NaCl and KCl, were volatilized by heating since 800 °C. The total contents of S and P in the biomass ashes were associated to CaSO₄, and a complex phosphate identified by XRD. CaCO₃ present at 600 °C was decomposed to CaO with disappearance at 1000 °C. By heating, new silicates were formed by solid-state reactions in the biomass residue. The minor elements have been found in a relative proportion lower than 0.9 wt.% and they characterized the obtained ashes, with potential use as micronutrients.

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Predicting early death in older adults with cancer

Publication date: September 2018
Source:European Journal of Cancer, Volume 100
Author(s): Rabia Boulahssass, Sebastien Gonfrier, Jean -Marc Ferrero, Marine Sanchez, Véronique Mari, Olivier Moranne, Cyrielle Rambaud, Francine Auben, Jean -Michel Hannoun levi, Jean -Marc Bereder, Isabelle Bereder, Patrick Baque, Jean Michel Turpin, Anne-Claire Frin, Delphine Ouvrier, Delphine Borchiellini, Remy Largillier, Guillaume Sacco, Jerome Delotte, Cyprien Arlaud, Daniel Benchimol, Matthieu Durand, Ludovic Evesque, Abakar Mahamat, Gilles Poissonnet, Jérôme Mouroux, Jérôme Barriere, Emmanuel Benizri, Thierry Piche, Joel Guigay, Eric Francois, Olivier Guerin
BackgroundPredicting early death after a comprehensive geriatric assessment (CGA) is very difficult in clinical practice. The aim of this study was to develop a scoring system to estimate risk of death at 100 days in elderly cancer patients to assist the therapeutic decision.MethodsThis was a multicentric, prospective cohort study approved by an ethics committee. Elderly cancer patients aged older than 70 years were enrolled before the final therapeutic decision. A standardised CGA was made before the treatment decision at baseline. Within 100 days, event (death), oncologic and geriatric data were collected. Multivariate logistic regression was used to select the risk factors for the overall population. Score points were assigned to each risk factor using the β coefficient. Internal validation was performed by a bootstrap method. Calibration was assessed with the Hosmer–Lemeshow goodness of fit test and accuracy with the mean c-statistic.FindingsOne thousand fifty patients (mean age: 82 years) joined the study from April 2012 to December 2014. The independent predictors were metastatic cancers (odds ratio [OR] 2.5; 95% confidence interval [CI], [1.7–3.5] p<0 .001); gait speed<0.8 m/s (OR 2.1; 95% CI [1.3–3.3] p=0.001); Mini Nutritional Assessment (MNA) < 17 (OR 8; 95% CI; [3.7–17.3] p<0.001), MNA ≤23.5 and ≥ 17 (OR 4.4; 95% CI, [2.1–9.1) p<0.001); performance status (PS) > 2 (OR 1.7; 95% CI, [1.1–2.6)] p=0.015) and cancers other than breast cancer (OR 4; 95% CI, [2.1–7.9] p<0.001). We attributed 4 points for MNA<17, 3 points for MNA between ≤23.5 and ≥ 17, 2 points for metastatic cancers, 1 point for gait speed <0.8 m/s, 1 point for PS > 2 and 3 points for cancers other than breast cancer. The risk of death at 100 days was 4% for 0 to 6 points, 24% for 7 to 8 points, 39% for 9 to 10 points and 67% for 11 points.InterpretationTo our knowledge, this is the first score which estimates early death in elderly cancer patients. The system could assist in the treatment decision for elderly cancer patients.



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Training for Medical Oncologists on Shared Decision‐Making About Palliative Chemotherapy: A Randomized Controlled Trial

AbstractBackground.Systemic treatment for advanced cancer offers uncertain and sometimes limited benefit, while the burden can be high. This study examines the effect of shared decision‐making (SDM) training for medical oncologists on observed SDM in standardized patient assessments.Materials and Methods.A randomized controlled trial comparing training with standard practice was conducted. Medical oncologists and oncologists‐in‐training (n = 31) participated in a video‐recorded, standardized patient assessment at baseline (T0) and after 4 months (T1, after training). The training was based on a four‐stage SDM model and consisted of a reader, two group sessions (3.5 hours each), a booster session (1.5 hours), and a consultation card. The primary outcome was observed SDM as assessed with the Observing Patient Involvement scale (OPTION12) coded by observers blinded for arm. Secondary outcomes were observed SDM per stage, communication skills, and oncologists' satisfaction with communication.Results.The training had a significant and large effect on observed SDM in the simulated consultations (Cohen's f = 0.62) and improved observed SDM behavior in all four SDM stages (f = 0.39–0.72). The training improved oncologists' information provision skills (f = 0.77), skills related to anticipating/responding to emotions (f = 0.42), and their satisfaction with the consultation (f = 0.53).Conclusion.Training medical oncologists in SDM about palliative systemic treatment improves their performance in simulated consultations. The next step is to examine the effect of such training on SDM in clinical practice and on patient outcomes.Implications for Practice.Systemic treatment for advanced cancer offers uncertain and sometimes limited benefit, while the burden can be high. Hence, applying the premises of shared decision‐making (SDM) is recommended. SDM is increasingly advocated based on the ethical imperative to provide patient‐centered care and the increasing evidence for beneficial patient outcomes. Few studies examined the effectiveness of SDM training in robust designs. This randomized controlled trial demonstrated that SDM training (10 hours) improves oncologists' performance in consultations with standardized patients. The next step is to examine the effect of training on oncologists' performance and patient outcomes in clinical practice.

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Developing a Roadmap for Interventional Oncology

AbstractInterventional oncology uses image‐guided procedures to enhance cancer care. Today, this specialty plays an increasingly critical role in cancer diagnosis (e.g., biopsy), cancer therapy (e.g., ablation or embolization), and cancer symptom palliation (e.g., nephrostomies or biliary drainages). Although the number of procedures and technical capabilities has improved over the last few years, challenges remain. In this article we discuss the need to advance existing procedures, develop new ones, and focus on several operational aspects that will dictate future interventional techniques to enhance cancer care, particularly by accelerating drug development and improving patient outcomes.Implications for Practice.Interventional oncology is vital for cancer diagnosis, therapy, and symptom palliation. This report focuses on current interventional procedures and techniques with a look toward future improvements that will improve cancer care and patient outcomes.

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Fear of Mastectomy Associated with Delayed Breast Cancer Presentation Among Ghanaian Women

AbstractBackground.Breast cancer is the leading cause of cancer mortality among women globally. Most women in Ghana present with advanced stage disease. The aim of this study is to characterize sociocultural factors associated with delayed presentation.Materials and Methods.Qualitative study (grounded theory, constant comparative method) using individual in‐depth interviews with breast cancer patients seen at the Korle Bu Teaching Hospital in Accra, Ghana. Interviews were conducted in English and three local languages. We achieved theoretical saturation with 31 participants.Results.The mean length of delay reported by patients was approximately 1 year. Five recurrent themes were related to delayed presentation: (a) Women with a confirmed breast cancer diagnosis delay treatment because of the fear of mastectomy due to self and societal stigma; (b) role of the church as a social support system given the societal stigma associated with breast cancer; (c) study participants expressed some awareness of breast cancer, but with varying depths of breast cancer knowledge encompassing both myths and misconceptions about breast cancer; (d) most patients present late because they do not associate a "painless" breast lump with possible breast malignancy; and (e) delayed presentation linked to significant financial burden associated with breast cancer treatment.Conclusion.Despite current efforts to increase breast cancer awareness, the fear of mastectomy remains one of the main reasons for delayed presentation. Successful breast cancer education programs will need to be framed within the broader sociocultural dimensions of femininity that address some of the stigma associated with mastectomy reported in the Ghanaian context.Implications for Practice.Most women in Ghana present with advanced‐stage disease. The aim of this study was to characterize sociocultural factors associated with delayed presentation. Although several quantitative studies have been conducted on delays in presentation in sub‐Saharan Africa (SSA), this study is one of the few to identify fear of mastectomy as a reason for delayed presentation. Anecdotal data from current clinical experiences in SSA suggest that this is still an issue that has not been adequately reported and addressed in most SSA countries. The research results presented here will hopefully guide health providers and national organizations in designing breast cancer education programs in Ghana and other parts of SSA.

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Occlusion, temporomandibular disorders, and orofacial pain: An evidence-based overview and update with recommendations

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Michael J. Racich
This paper presents an overview of dental disciplines involved in the treatment of orofacial pain, temporomandibular disorders (TMD), and occlusion and provides an evidence-based contemporary update of their interrelationships. English language peer-reviewed articles were identified using PubMed. Key words bruxism, implants, occlusion, orofacial pain, orthodontics, prosthodontics, restorative dentistry, and TMD were used.



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Replacement of maxillary incisor crowns over discolored substrates in a single visit with a CAD-CAM system and lithium silicate ceramic

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Gustavo Dartora, Pedro Henrique Wentz Tretto, Rodrigo Varella de Carvalho, Atais Bacchi
Discolored substrates constitute a challenge to the esthetics of the definitive restoration. Because of technique sensitivity, the generally prolonged treatment time is a drawback to both the patient and the dentist. The technique described presents the replacement of ceramic maxillary incisors crowns over discolored substrates in a single visit by using a milling machine. Translucent blocks of a lithium silicate ceramic reinforced with zirconium dioxide particles were used. Intraoral scans of the trial restorations and of the tooth preparations were performed. The crown parameters were defined in the software. Ceramic blocks were milled in the presintered phase and characterized. The crowns were cemented at the end of the appointment with excellent esthetics.



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Comparison of marginal fit between CAD-CAM and hot-press lithium disilicate crowns

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Eran Dolev, Yoli Bitterman, Avi Meirowitz
Statement of problemHot-pressing and computer-aided design and computer-aided manufacturing (CAD-CAM) are major techniques for the fabrication of lithium disilicate crowns. They exhibit different accuracies regarding marginal fit, an important factor in restoration survival. However, studies comparing the marginal fit of different fabrication methods are lacking.PurposeThe purpose of this in vitro study was to compare the marginal discrepancy (MD) and absolute marginal discrepancy (AMD) of lithium disilicate crowns produced by the hot-press and CAD-CAM techniques.Material and methodsThirty (30) typodont teeth were divided into 2 groups. Fifteen teeth were scanned with the CEREC Omnicam intraoral scanner, and crowns were fabricated with the CEREC MC XL chairside CAD-CAM milling unit from IPS e.max CAD blocks. Fifteen typodont teeth were sent to a dental laboratory, and lithium disilicate crowns were fabricated from IPS e.max press ingots using the hot-press technique. The 30 crowns were cemented and then sectioned with a precision saw. The MD and AMD were measured for each crown with a light microscope. One-way ANOVA was conducted to analyze significant differences in crown marginal fit between the fabrication systems (α=.05).ResultsFor the CAD-CAM technique, the mean values of the AMD measurements were 115 μm, and for the hot-press technique, 130 μm. The MD measurements were 87 μm for the CAD-CAM technique and 90 μm for the hot-press technique. One-way ANOVA revealed no significant differences between the fabrication methods regarding marginal fit (P>05).ConclusionsNo significant differences were found between the fabrication methods tested. Both the CAD-CAM and hot-press techniques for producing monolithic lithium disilicate crowns produced MD values of less than 120 μm, within the clinically acceptable range.



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A digital technique for fabricating an interim implant-supported fixed prosthesis immediately after implant placement in patients with complete edentulism

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Ji-Hyeon Oh, Xueyin An, Seung-Mi Jeong, Byung-Ho Choi
The conversion of a denture into an interim implant-supported, screw-retained restoration has become the standard method for immediate interim restoration in patients with complete edentulism. The most critical steps of the denture conversion process are the creation of appropriate denture access holes to prevent displacement of the denture by the interim cylinders and removal of the denture flanges to facilitate both good esthetics and accessibility for oral hygiene after the denture is connected to the interim cylinders. This article presents a digital technique for designing and fabricating an interim implant-supported, fixed prosthesis for edentulous patients. The interim prosthesis has cylinder access holes that are digitally prefabricated and a denture flange part that is designed to be easily sectioned. This technique facilitates more straightforward and efficient immediate restoration for edentulous patients after implant placement.



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Retentive strength and marginal discrepancies of a ceramic-reinforced calcium phosphate luting agent: An in vitro pilot study

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Rishabh P. Acharya, Steven M. Morgano, Allyn C. Luke, Saul Weiner
Statement of problemInformation on the properties of a relatively new luting agent with a unique formulation (ceramic-reinforced calcium phosphate) is limited.PurposeThe purpose of this in vitro study was to compare the retentive strengths and marginal discrepancies of a ceramic-reinforced calcium phosphate luting agent (CM) with a self-adhesive resin luting agent (RX) and to determine and compare the mode of failure of dislodged cemented copings.Material and methodsForty extracted human molar teeth were prepared to receive zirconia copings. After cementation, the specimens were divided into 4 subgroups (n=10): CM A (axial loading), CM OA (off-axis loading), RX A (axial loading), and RX OA (off-axis loading). For each subgroup, 9 of the specimens received experimental treatment (thermocycling and dynamic loading), and the tenth received no experimental treatment. Eight copings were pulled off in a universal testing machine (MTS Insight; MTS). The ninth specimen was treated experimentally but was not pull tested. The marginal discrepancy and the dentin interface of the specimens that were not pull tested were analyzed with scanning electron microscopy and energy dispersion spectroscopy. The mode of failure of the dislodged copings was also subjectively evaluated.ResultsThe mean retentive strengths were 5.92 MPa for CM A, 5.81 MPa for CM OA, 5.75 MPa for RX A, and 5.69 MPa for RX OA. The marginal discrepancy recorded for both CM and RX ranged from 30 to 45 μm, (mean, 36 ±4.6 μm). Energy dispersion spectroscopy analysis showed the presence of calcium, phosphorus, silicon, and aluminum for the CM marginal discrepancy and the presence of aluminum in the dentinal tubules adjacent to the CM. Calcium and phosphorus were detected in lesser amounts adjacent to the RX marginal discrepancy. The mode of failure for CM was primarily adhesive to the tooth preparation, and, for RX, the failure mode was predominantly adhesive to the coping.ConclusionsCM had statistically significantly higher mean retentive strength compared with RX. Subgroups loaded axially had statistically significantly higher retentive strengths compared with those loaded off axis.



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Use of finite element analysis for the assessment of biomechanical factors related to pain sensation beneath complete dentures during mastication

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Jaroslaw Żmudzki, Grzegorz Chladek, Piotr Malara
Statement of problemThe pain commonly suffered by denture wearers during mastication is not documented in the objective biomechanical criteria for the pressure pain threshold.PurposeThe purpose of this finite element analysis study was to determine whether the pressures developed beneath a removable mandibular complete denture during mastication would exceed the average pressure pain threshold in patients for whom the denture foundation had an acceptable load-bearing capacity.Material and methodsA patient with an acceptable load-bearing denture foundation was modeled with finite element analysis. The denture/mucosa interface was modeled as a sliding or detaching interface. A convex mandibular residual ridge, resilient mucosa, and denture were modeled in computer-aided design (CAD) software using curves and cross sections. A unilateral vertical occlusal load of 100 N was assumed only for model verification, and an oblique mastication load of 141 N was assumed for simulated mastication with balanced articulation. The nonworking-side occlusal contact was simulated in 2 situations: prompt nonworking-side occlusal contact and delayed nonworking-side occlusal contact by setting an initial distance of 0.1 mm or 1 mm between the denture and a flat solid above the nonworking side.ResultsThe denture was held to the mucosa under vertical force and a maximum pressure of 203 kPa. The denture was tilted under an oblique mastication load and achieved stability through nonworking-side occlusal contact. This means that the denture was supported not only by the denture foundation but also by the nonworking-side occlusal contact and had a downwardly directed stabilizing reaction force. The denture was weakly supported on the delayed nonworking-side occlusal contact compared with the prompt nonworking-side occlusal contact and weakly supported on the denture foundation. In delayed nonworking-side occlusal contact, the pressure beneath the denture was 783 kPa (>pressure pain threshold) compared with 484 kPa (<pressure pain threshold) in prompt nonworking-side occlusal contact. Despite the lower reaction force of the foundation in delayed nonworking-side occlusal contact, the pressure beneath the denture increased, indicating a reduction in the load transfer area due to the inclined position of the denture. Friction on the mucosal surface was over 14-fold higher for the delayed nonworking-side occlusal contact.ConclusionsThe pressure beneath a removable mandibular complete denture exceeded the average pressure pain threshold and was supported with a large slide, which produced friction. Although the value of the load on the occlusal side did not change, the pressure under the denture increased and the force of nonworking-side occlusal contact decreased because of increasing distance to nonworking-side occlusal contact.



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Adhesive evaluation of three types of resilient denture liners bonded to heat-polymerized, autopolymerized, or CAD-CAM acrylic resin denture bases

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Jung Eun Choi, Tracey E. Ng, Chloe K.Y. Leong, Hansol Kim, Pu Li, John Neil Waddell
Statement of problemLevels of bond strength between different types of resilient denture liner materials bonded to different denture base acrylic resins, CAD-CAM acrylic resins in particular, have not been well reported.PurposeThe purpose of this study was to measure the tensile bond strength and durability of various combinations of 3 different resilient denture liners bonded to 3 different poly(methyl methacrylate) denture base materials.Material and methodsThe tensile bond strength of 3 resilient denture liners, namely Ufi Gel SC, Silagum-Comfort, and Vertex Soft, combined with heat-polymerized (Vertex Rapid Simplified), autopolymerized (Vertex Self-Curing), and computer-aided design and computer-aided manufacturing (CAD-CAM) (IvoBase CAD) denture base resins were tested by using a universal testing machine (total N=138). Half of the specimens were thermocycled between 5°C and 55°C for 1500 cycles before testing. After testing, modes of failure and interface surfaces were examined using light microscopy and scanning electron microscopy, respectively. Thermogravimetric analysis was carried out to analyze the differences in content between the 3 different denture base acrylic resins.ResultsThe mean tensile bond strength values ranged from 0.36 ±0.1 MPa to 1.51 ±0.46 MPa. CAD-CAM denture base materials showed the lowest range of bond strength when coupled to resilient denture liners (0.36 to 0.42 MPa). No statistically significant differences (P=.74) were found in bond strength between the thermocycled (0.71 ±0.23 MPa) and non-thermocycled groups (0.74 ±0.21 MPa). Silicone-based resilient denture liners exhibited the highest tensile strength with each type of denture resin. All 3 types of failure modes (adhesive, cohesive, and mixed modes) were observed.ConclusionsSilicone-based resilient denture liners produced the highest tensile bond strength to all denture bases tested. Resilient denture liners bonded to CAD-CAM denture bases produced the weakest tensile bond strengths. Thermocycling did not produce statistically significant differences in tensile bond strength of the resilient denture liners to the denture base resins.



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Osteogenesis ability of CAD-CAM biodegradable polylactic acid scaffolds for reconstruction of jaw defects

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Mohamed H. Helal, Hebatullah D. Hendawy, Rowan A. Gaber, Nourhan R. Helal, Moustafa N. Aboushelib
Statement of problemReconstruction of alveolar bony defects is difficult using grafting materials in a powder form. A biodegradable scaffold material might simplify the procedure.PurposeThe purpose of this in vivo study was to evaluate osteogenesis ability of a biodegradable CAD-CAM–fabricated polylactic acid (PLA) scaffold enriched with calcium phosphate salts including hydroxyapatite (HA) and beta tricalcium phosphate (β-TCP) used to reconstruct mandibular defects in a dog model.Material and methodsSurgical defects were made bilaterally in the mandible of male beagle dogs. Computerized tomography images were obtained for determination of the 3-dimensional shape of the defects after 3 months of healing. Porous PLA scaffolds were fabricated by milling custom-made CAD-CAM blocks into the desired shape. After milling, half of the scaffolds were prepared by filling the pores of the scaffolds by a mixture of HA and β-TCP. Scaffolds were inserted in the mandibular defects bilaterally. After a healing time of 8 weeks, the bone-scaffold interface was analyzed histomorphometrically to detect the amount of new bone formation. Stained histological sections were examined using a computer software and depth of new bone formation was assessed (n=14, α=.05).ResultsHistomorphometric analysis revealed that enriched scaffolds with calcium phosphates had significantly (t=4.4, P<.001) higher amounts of new bone formation (1.3 ±0.33 mm) compared with the controls (0.7 ±0.39 mm). Average new bone growth in enriched scaffolds was 1.3 mm while almost half this value was observed in uncoated scaffolds, 0.7 mm.ConclusionsWithin the limitations of this animal study, HA and β-TCP enhanced osteogenesis ability of CAD-CAM–fabricated PLA scaffolds.



https://ift.tt/2KzeN47

Retention force and deformation of an innovative attachment model for mini-implant–retained overdentures

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Mariana L.C. Valente, Marcos V.W. Shimano, José A.M. Agnelli, Andréa C. dos Reis
Statement of problemThe gradual loss of retention and the need for periodic replacement of attachment-system components are the most frequent complications in implant-supported overdentures.PurposeThe purpose of this in vitro study was to develop a new attachment system for overdentures with polymeric materials and compare its retention and deformation with a conventional O-ring attachment system.Material and methodsA matrix with 2 mini-implants with ball abutments was used to simulate the mandibular border during a fatigue resistance test. A total of 60 polyacetal (n=20), polytetrafluoroethylene (n=20), and conventional O-ring (n=20) attachments were captured in pairs with acrylic resin and subjected to 3625 insertion and removal cycles, simulating 30 months of overdenture use. The internal and external deformations of the attachments were assessed using an optical stereomicroscope. One-way ANOVA and the Tukey honestly significant difference tests were used for statistical evaluation (α=.05).ResultsThe polyacetal attachment system showed the highest retention (P<.001), followed by the O-ring and polytetrafluoroethylene attachments. The O-ring attachments exhibited the lowest deformation (P<.001), and the polyacetal attachments had the highest internal deformation (P<.001).ConclusionsThe newly developed polyacetal attachment model increased the retention of mini-implant–retained overdentures, and despite the deformation experienced, the retention period appears to be better than that of conventional systems.



https://ift.tt/2Kz7uGv

Accuracy of 3-dimensional computer-aided manufactured single-tooth implant definitive casts

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Michele Buda, Manuel Bratos, John A. Sorensen
Statement of problemThe integration of the digital workflow into routine prosthodontic practice for single-tooth implant surgery and fixed prosthesis fabrication has occurred at a remarkable pace in the last 5 years. With the greater demands of esthetics and precision, the definitive implant analog cast must ensure accurate implant positioning as well as an accurate relationship to adjacent teeth.PurposeThe purpose of this in vitro study was to evaluate the accuracy of the 3-dimensional (3D) implant position of definitive casts produced by 3D printing and analog technology.Material and methodsA master patient model was created from a dentate typodont. The maxillary left central incisor was removed, and a Straumann RC implant was positioned for a screw-retained prosthesis. A laboratory scanner with an accuracy of 5 μm was used for all scanning. A scanbody was connected to the master model implant and scanned to create a master patient file, which served as the control master patient for all comparisons. The two 3D printing systems used for this study were the Statasys Objet500 (group OBJ), an industrial Polyjet production system, and the Formlabs Formlab 2 (group FORM), a budget SLA Vat system. In addition, a conventional gypsum cast (group GYP) with an implant analog was made with elastomeric impression material. With a sample size of 10 per group, each gypsum cast and 2 printed group casts were scanned with the D2000 laboratory scanner 5 times per cast. Convince software (3Shape) was used for 3D analysis to calculate accuracy. The following variables were measured: implant analog vertical displacement, horizontal displacement of implant platform and apex, degree of tilting in the vertical axis, and rotational position change around the vertical axis. Means and standard deviations were calculated for trueness. One-way ANOVA and the post hoc t test with Bonferroni correction were used to investigate any significant differences among the experimental groups (α=.05).ResultsFor vertical displacement of the implant body, group OBJ had the lowest value of –30 ±24 μm. The values obtained for OBJ and FORM were significantly different from that obtained for GYP (P<.05). For horizontal displacement of the implant shoulder, Group OBJ had the lowest value, 85 ±12 μm, and the difference among these groups was significantly different (P<.05). The value for horizontal displacement of the implant apex was 123 ±25 μm for group OBJ and not significantly different from that obtained for group GYP (136 ±40 μm) but significantly different from that obtained for group FORM (326 ±54 µm). Also, the analysis of implant body tilting in the vertical axis showed significant differences between the values obtained for groups GYP and OBJ and between the values obtained for groups OBJ and FORM. With regard to implant rotational position change around the vertical axis, the values obtained for the gypsum cast and group FORM were not statistically different from those obtained for the master patient control model (P>.05). However, the implant orientation of group OBJ was significantly different from the orientation of groups GYP and FORM (P<.05). The actual clinical relevance of these printing system discrepancies is yet to be determined because the level of clinical acceptable discrepancy in the x, y, and z vectors is still undefined.ConclusionsThis study showed statistically significant differences in accuracy among the implant analog cast fabrication systems; however; the level of clinical acceptable discrepancy is still undefined. Although further research is needed, this study supports the conclusion that the Polyjet industrial printing system was more accurate than the conventional implant analog gypsum cast.



https://ift.tt/2KgUOYu

Comparison of user satisfaction and image quality of fixed and mobile camera systems for 3-dimensional image capture of edentulous patients: A pilot clinical study

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Irena Sailer, Shiming Liu, Roland Mörzinger, Marcel Lancelle, Thabo Beeler, Markus Gross, Chenglei Wu, Vincent Fehmer, Murali Srinivasan
Statement of problemAn evaluation of user satisfaction and image quality of a novel handheld purpose-built mobile camera system for 3-dimensional (3D) facial acquisition is lacking.PurposeThe purpose of this pilot clinical study was to assess and compare the effectiveness between a handheld mobile camera system designed for facial acquisition and a fixed static camera arrangement by comparing the time effectiveness and the operator and participant preference for the 2 techniques of image capture.Material and methodsCompletely edentulous participants (n=12: women=7, men=5; mean age: 74.6 years) were included in this pilot study. Images were captured with and without the prostheses in situ while maintaining "serious" and "full-smile" facial expressions. Images were captured using a mobile and a static system. The working times for the participant installation and image captures were recorded. Operator and participant perceptions of the entire experience were recorded by using visual analog scale questionnaires. Nonparametric tests were used for statistical analyses (α=.05).ResultsThe installation time was significantly shorter for the mobile system (static=24 ±13 seconds; mobile=10 ±10 seconds), but the differences in the image capture times were not statistically significant (static: 29 ±5 seconds; mobile: 40 ±18 seconds). Operator preference was in favor of the mobile system with regard to working time (P=.002), difficulty in using (installation: P=.002; handling: P=.045), and camera weight (P=.002); however, they preferred the static arrangement for image quality (P=.003) and comfort (P=.013). The participants rated the entire photographic experience favorably, and 10 of 12 participants preferred the static camera over the mobile one.ConclusionsDespite the complexity of the installation, the static system was evaluated better for image quality; the mobile system was easier in installation and handling. The operators preferred the mobile system, and the participants preferred the static system.



https://ift.tt/2IAk1HP

Load-bearing capacity of simulated Locator-retained overdenture system

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Mona Gibreel, Lippo V.J. Lassila, Timo O. Närhi, Leila Perea-Lowery, Pekka K. Vallittu
Statement of problemAcrylic resin overdenture bases usually fracture because of stress concentrations at the area of the abutments.PurposeThe purpose of this study was to evaluate the reinforcing effect of bidirectional woven electrical glass (E-glass) fiber weaves with a different number of layers and different locations on the load-bearing capacity of simulated Locator-retained overdenture specimens.Material and methodsTest specimens with a centrally located metal housing for a Locator stud attachment were fabricated from autopolymerizing acrylic resin (polymethylmethacrylate based) and reinforced with bidirectional woven E-glass fiber layers. The control group specimens were fabricated without fiber reinforcement. The 2L group had 2 layers of E-glass fiber weaves and was divided according to the fiber location within the specimens as follows: 2L-A subgroup with 2 fiber layers above the metal housing; 2L-N subgroup with 2 fiber layers adjacent to the housing; and 2L-A+2L-N subgroup with 2 fiber layers above and 2 fiber layers adjacent to the housing. The 4L group had 4 layers of E-glass fiber weaves and was divided according to the fiber location as follows: 4L-A subgroup with 4 fiber layers above the housing; 4L-N subgroup with 4 fiber layers adjacent to the housing; and 4L-A+4L-N subgroup with 4 fiber layers above and 4 fiber layers adjacent to the housing. Dry specimens were submitted to a 3-point static loading test, and the mean flexural strength, flexural modulus, and strain values were analyzed with 1-way ANOVA and Tukey post hoc tests (α=.05). Two-way ANOVA was conducted to detect the influence of the number and location of the reinforcing layers (α=.05).ResultsThe results revealed a significant difference (P<.001) in flexural strength values between the control group (92.4 ±14 MPa) and the 2 subgroups, 4L-A (116 ±7.3 MPa) and 4L-A+4L-N (117.1 ±6 MPa), with a significant effect only from the number of the reinforcing layers (P<.001) and not the location (P=.153). No significant differences were found with flexural modulus (P=.195) and strain values (P=.174) among the tested groups.ConclusionsThe load-bearing capacity of a Locator-retained overdenture can be significantly increased by placing 4 layers of bidirectional woven E-glass fiber weaves either only above the metal housing or in both locations above and adjacent to the metal.



https://ift.tt/2KrZWZl

In vitro retention of prefabricated and individually formed posts: A pilot study

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Ivana Parčina Amižić, Ivana Miletić, Anja Baraba, Yuwei Fan, Dan Nathanson
Statement of problemData on the retention of individually formed fiber-reinforced composite posts (everStick) cemented with self-adhesive cement are lacking.PurposeThe purpose of this in vitro study was to investigate the pull-out strength of 2 different fiber-reinforced composite posts (prefabricated and individually formed) cemented into extracted teeth with self-adhesive resin cement.Material and methodsThirty extracted single-rooted human teeth were decoronated, endodontically treated, and prepared with post spaces of equal length. Prepared specimens were divided into 2 groups (n=15 each) based on the type of post: commercially prefabricated fiber posts (GC) and individually formed resin posts (using GC reinforcing fibers). Self-adhesive resin cement (G-CEM LinkAce; GC) was used to cement all posts. Each post was held with moderate pressure, and root surfaces were light polymerized for 20 seconds (650 mW/cm²). After cementation, the specimens were stored in saline solution for 30 days. Treated teeth were kept in water for 24 hours before pull-out testing parallel to the longitudinal axis of the posts. Data were analyzed using the Student t test (α=.05) and the coefficient of variance as the ratio of the standard deviation to the mean.ResultsThe mean pull-out retention strength was 185.7 ±61.2 N for the prefabricated fiber posts and 98.9 ±56.5 N for the individually formed fiber posts (P=.026).ConclusionsThe prefabricated fiber posts exhibited significantly higher retention forces than the individually formed posts.



https://ift.tt/2Kxc1ZI

Digital workflow to rehabilitate worn dentition on a non-hinge simulated patient

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Ramtin Sadid-Zadeh, Anthony Alexander
This report describes the complete mouth rehabilitation of worn dentition by using a digital workflow on a non-hinge simulated patient. A dentiform was used to simulate a patient with loss of occlusal vertical dimension. Physical diagnostic waxing along with a digital workflow was then used to re-establish the occlusal vertical dimension at the interim and definitive restoration stages.



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Combination of digital photographs for the identification of the screw-access hole of cement-retained implant restorations

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Konstantinos Michalakis, Hiroshi Hirayama




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Should the restoration of adjacent implants be splinted or nonsplinted? A systematic review and meta-analysis

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Victor E. de Souza Batista, Fellippo R. Verri, Cleidiel A.A. Lemos, Ronaldo S. Cruz, Hiskell F.F. Oliveira, Jéssica M.L. Gomes, Eduardo P. Pellizzer
Statement of problemThe decision to splint or to restore independently generally occurs during the planning stage, when the advantages and disadvantages of each clinical situation are considered based on the proposed treatment. However, clinical evidence to help clinicians make this decision is lacking.PurposeThe purpose of this systematic review and meta-analysis was to assess the marginal bone loss, implant survival rate, and prosthetic complications of splinted and nonsplinted implant restorations.Material and methodsThis study was designed according to the Cochrane criteria for elaborating a systematic review and meta-analysis and adopted the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Also, this review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42017080162). An electronic search in the PubMed/MEDLINE, Cochrane Library, and Scopus databases was conducted up to November 2017. A specific clinical question was structured according to the population, intervention, comparison, outcome (PICO) approach. The addressed focused question was "Should the restoration of adjacent implants be splinted or nonsplinted?" The meta-analysis was based on the Mantel-Haenszel and inverse variance methods to assess the marginal bone loss, implant survival, and prosthetic complications of splinted and nonsplinted implant restorations.ResultsNineteen studies were selected for qualitative and quantitative analyses. A total of 4215 implants were placed in 2185 patients (splinted, 2768; nonsplinted, 1447); the mean follow-up was 87.8 months (range=12-264 months). Quantitative analysis found no significant differences between splinted and nonsplinted restorations for marginal bone loss. The assessed studies reported that 75 implants failed (3.4%), of which 24 were splinted (99.1% of survival rate) and 51 were nonsplinted (96.5% of survival rate). Quantitative analysis of all studies showed statistically significant higher survival rates for splinted restorations than for nonsplinted restorations. Ceramic chipping, screw loosening, abutment screw breakage, and soft tissue inflammation were reported in the selected studies. The quantitative analysis found no statistically significant difference in the prosthetic complications of splinted and nonsplinted restorations.ConclusionsWithin the limitations of this systematic review and meta-analysis, it was concluded that there was no difference in the marginal bone loss and prosthetic complications of splinted and nonsplinted implant restorations; this is especially true for restorations in the posterior region. However, splinted restorations were associated with decreased implant failure.



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Fracture resistance and 2-body wear of 3-dimensional–printed occlusal devices

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Anna-Maria Lutz, Rüdiger Hampe, Malgorzata Roos, Nina Lümkemann, Marlis Eichberger, Bogna Stawarczyk
Statement of problemPolymeric material for 3-dimensional printing can be used to fabricate occlusal devices. However, information about fracture resistance and wear is scarce.PurposeThe purpose of this in vitro study was to investigate the fracture resistance and 2-body wear of 3-dimensional–printed (3DP) (FotoDent splint; Dreve Dentamid GmbH), milled polymethylmethacrylate (CAM) (Temp Basic; Transpa 95H16, Zirkonzahn GmbH), and conventionally fabricated polymethylmethacrylate (CAST) (Castdon; Dreve Dentamid GmbH) occlusal devices.Material and methodsA total of 96 occlusal devices were prepared according to the 3 different manufacturing techniques 3DP, CAM, and CAST (n=32). For each manufacturing technique, specimens were further divided into initial fracture resistance tests (n=16) and artificial aging in the mastication simulator (50 N, 37°C) with 2-body wear followed by fracture resistance tests (n=16). The fracture resistance was determined using a universal testing machine (1 mm/min). The wear was measured after 20 000 and 120 000 mastication cycles with the replica technique, mapped with a laser scanner, and quantified in R software. Data were analyzed using a 2-way ANOVA followed by a 1-way ANOVA with Scheffé or Games-Howell post hoc tests, repeated measures ANOVA with corrected Greenhouse-Geisser P values, and the Levene, Mann-Whitney, and paired t tests (α=.05).ResultsCAM presented higher initial fracture resistance than 3DP or CAST (P<.001). After mastication simulation, CAM followed by 3DP showed higher fracture resistance than CAST (P<.001). Mastication simulation decreased the fracture resistance for CAM and CAST (P<.001) but not for 3DP (P=.78). Three-dimensional–printed occlusal devices showed the highest material volume loss, followed by CAM and the lowest in CAST (P<.001).ConclusionsThree-dimensional–printed occlusal devices showed lower wear resistance and lower fracture resistance than those milled or conventionally fabricated. Therefore, only short-term application in the mouth is recommended. Further developments of occlusal device material for 3-dimensional printing are necessary.



https://ift.tt/2KB7lSZ

In vivo biocompatibility of an interim denture resilient liner containing antifungal drugs

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Juliana Hotta, Gustavo Pompermeier Garlet, Tania Mary Cestari, Jozely Francisca Mello Lima, Vinícius Carvalho Porto, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek
Statement of problemAntifungal agents incorporated into interim denture resilient liners have been suggested as an adjunct treatment for denture stomatitis (DS). However, before applying this protocol to humans, biocompatibility analysis of such drugs in animal models is required.PurposeThe purpose of this animal study was to evaluate the in vivo biocompatibility of an interim resilient liner modified with minimum inhibitory concentrations (MICs) of antifungal drugs for Candida albicans biofilm.Material and methodsSixty Wistar rats were divided into 6 groups (n=5): PC=positive control/no protocol; IOD (intraoral device)=rats using an acrylic resin palatal device (PD); Tru=rats using a PD relined with Trusoft; and Ny (nystatin), Chx (chlorhexidine diacetate), and Ke (ketoconazole) groups=rats using a PD relined with Trusoft + drug MICs. The rats were sacrificed at 7 or 14 days of trial. Histopathological qualitative analysis was performed by comparing photomicrographs of histological sections of the intermolar region. Morphological changes in the epithelium and keratin were quantitatively analyzed by computerized planimetry, and data were analyzed by using 2-way ANOVA and the Tukey HSD test (α=.05).ResultsQuantitative analysis showed that only PD containing Ke significantly decreased the thickness and area of the keratin compared with the other groups (P<.001), which showed no differences between each other (P>.05). These results agreed with those of qualitative analysis.ConclusionsIncorporation of MICs of Ny and Chx in Trusoft did not induce histopathological changes in the rat palatal mucosa, suggesting the in vivo biocompatibility of this DS treatment.



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Digital workflow for the design and additively manufacture of a splinted framework and custom tray for the impression of multiple implants: A dental technique

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Wenceslao Piedra Cascón, Marta Revilla-León
This article describes a step-by-step digital protocol for the design and fabrication, through additive manufacturing, of a splinted framework and a custom tray for the impression of a complete-arch prosthesis supported by multiple implants. The protocol presented uses open source software to control the thicknesses of the custom tray, splinting material, and impression material during the procedure, reducing laboratory and chairside time and costs.



https://ift.tt/2IEijW1

Comparison of fit accuracy of pressed lithium disilicate inlays fabricated from wax or resin patterns with conventional and CAD-CAM technologies

Publication date: Available online 29 June 2018
Source:The Journal of Prosthetic Dentistry
Author(s): Foudda R. Homsy, Mutlu Özcan, Marwan Khoury, Zeina A.K. Majzoub
Statement of problemThe use of resin patterns to produce partial coverage restorations is poorly documented.PurposeThe purpose of this in vitro study was to compare the marginal and internal fit accuracy of lithium disilicate glass-ceramic inlays obtained from wax or resin patterns and fabricated with digital and conventional techniques.Material and methodsA dentoform mandibular first molar was prepared for a mesio-occlusal ceramic inlay. Six groups of 15 inlays were obtained by conventional impression and manual wax (group CICW) or resin patterns (group CICR); conventional impression, laboratory scanning of the stone die, CAD-CAM milled wax (group CIDW), or polymethylmethacrylate (PMMA) blocks (group CIDR); and scanning of the master preparation with an intraoral scanner, CAD-CAM milled wax (group DSDW), or PMMA blocks (DSDR). The same design was applied to produce the wax and PMMA patterns in the last 4 groups. The replica technique was used to measure marginal and internal fit under stereomicroscopy. Mixed-model ANOVA was applied to assess differences according to the techniques, materials, and discrepancy location (α=.05).ResultsThe results demonstrated significant effects of the technique (P<.001), material (P=.009), and discrepancy location (P<.001) on fit measurements. Marginal discrepancy was only affected by the technique (P<.001), with the digital approaches yielding the smallest marginal discrepancy (23.5 ±3.6 μm), followed by the conventional digital techniques (31.1 ±5.6 μm) and finally by the conventional (42.8 ±7.2 μm) techniques. Internal fit was significantly influenced only by the material with lower discrepancy in wax (75.2 ±9.0 μm) than in resin patterns (84.7 ±15.1 μm). The internal discrepancy was significantly larger than the marginal discrepancy in all groups (P<.001).ConclusionsInlays generated from conventional wax and resin patterns tend to show higher marginal discrepancies than conventional digital and full digital patterns. Wax and resin materials yield similar marginal fit accuracies irrespective of the impression/manufacturing technique. Better internal fit was shown in wax than in resin patterns, regardless of the technique.



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Seeing-and Nursing-Our Power.

Author: Kennedy, Maureen Shawn MA, RN, FAAN

Page: 7

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What RNs Can Do to Improve the Health of Their Communities.

Author: Ross, Barry MPH, MBA, BSN, RN

Page: 11

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HIV and Nurse Safety in China.

Author: Liu, Xiaoyan PhD

Page: 13

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Recognizing Lyme Disease.

Author: Dainsberg, Cynthia RN, FCN

Page: 13

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Simulation in Nursing Education.

Author: Hughes, Kevyn BSN, RN, CNML

Page: 13

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Joint Commission Issues Alert Addressing Violence Against Health Care Workers.

Author: Stockwell, Serena

Page: 14

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Ireland Proposes Promising Model for Nurse Staffing.

Author: Sofer, Dalia

Page: 15

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NewsCAP: The American Heart Association issues corrections to 2018 stroke guidelines.

Author:

Page: 15

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The Impact of Legalization of Medical and Recreational Marijuana.

Author: Mechcatie, Elizabeth MA, BSN

Page: 16

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NewsCAP: Soldiers in the U.S. Army who deploy within six months of an earlier deployment are at higher risk for suicide.

Author:

Page: 16

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NewsCAP: Each year an estimated 600 to 1,600 newborns fall or are dropped while in the hospital.

Author:

Page: 16

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State News Roundup.

Author:

Page: 17

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NewsCAP: Study finds that NPs, physicians, and physician assistants (PAs) in the VA system provide comparable diabetes management.

Author:

Page: 17

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NewsCAP: The WHO releases Consolidated Guideline on Sexual and Reproductive Health and Rights of Women Living with HIV .

Author:

Page: 17

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Can You Be Fired for Taking a Sick Day?.

Author: Nelson, Roxanne BSN, RN

Page: 18-19

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AJN On the Cover.

Author: Szulecki, Diane Editor

Page: 20

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AJN On the Web.

Author:

Page: 20

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Reducing Fall Risk in Older Adults.

Author: Haddad, Yara K. PharmD, MPH; Bergen, Gwen PhD, MPH, MS; Luo, Feijun PhD

Page: 21-22

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Promoting Drug Safety in Older Adults.

Author: Aschenbrenner, Diane S. MS, RN

Page: 23-24

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New HIV Drug Treats Patients Unresponsive to Other Therapies.

Author: Aschenbrenner, Diane S. MS, RN

Page: 24

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Biomedical applications of functional peptides in nano-systems

Publication date: September 2018
Source:Materials Today Chemistry, Volume 9
Author(s): Lei Rong, Si-Yong Qin, Chi Zhang, Yin-Jia Cheng, Jun Feng, Shi-Bo Wang, Xian-Zheng Zhang
During the past decades, functionalized nano-systems were believed in holding the bright future of the nanomaterials in biomedical applications. Due to their excellent biocompatibility, biodegradation capability, and biological activity, functional peptides have been vastly used solitary or employed as functional components in nano-systems for disease treatments. This review focuses on the recent advances on the use of functional peptides as a toolbox to construct various delivery nano-systems for tumor treatments. Arising from the special function contributed to the nano-systems, the functional peptides are mainly divided into three groups, cell-targeting peptides (CTPs), cell-penetrating peptides (CPPs), and environment-sensitive peptides. Within each group, their usage in both organic and inorganic systems is discussed. In particular, strategies used to generate promising therapeutic nano-systems for efficient tumor treatment are also highlighted.

Graphical abstract

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Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

Publication date: Available online 29 June 2018
Source:Journal of Autoimmunity
Author(s): Jody Ye, Tom G. Richardson, Wendy L. McArdle, Caroline L. Relton, Kathleen M. Gillespie, Matthew Suderman, Gibran Hemani
The risk of Type 1 Diabetes (T1D) comprises both genetic and environmental components. We investigated whether genetic susceptibility to T1D could be mediated by changes in DNA methylation, an epigenetic mechanism that potentially plays a role in autoimmune diabetes. From enrichment analysis, we found that there was a common genetic influence for both DNA methylation and T1D across the genome, implying that methylation could be either on the causal pathway to T1D or a non-causal biomarker of T1D genetic risk. Using data from a general population comprising blood samples taken at birth (n = 844), childhood (n = 846) and adolescence (n = 907), we then evaluated the associations between 64 top GWAS single nucleotide polymorphisms (SNPs) and DNA methylation levels at 55 non-HLA loci. We identified 95 proximal SNP-cytosine phosphate guanine (CpG) pairs (cis) and 1 distal SNP-CpG association (trans) consistently at birth, childhood, and adolescence. Combining genetic co-localization and Mendelian Randomization analysis, we provided evidence that at 5 loci, ITGB3BP, AFF3, PTPN2, CTSH and CTLA4, DNA methylation is potentially mediating the genetic risk of T1D mainly by influencing local gene expression.



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Removal of bisphenol A by Fe-impregnated activated carbons

Abstract

A commercial wood-based activated carbon and the oxidized counterpart were impregnated with iron. The two Fe-impregnated carbons were prepared and characterized for their iron content, textural characteristics, surface chemistry, and their performance for bisphenol A adsorption. Batch adsorption experiments were conducted to study the effect of pH, ionic strength, kinetics, and thermodynamic equilibrium. Equilibrium adsorption data were described by both Langmuir and Freundlich isotherms. The iron impregnated activated carbon and the oxidized impregnated activated carbon presented maximum adsorption capacities of 785.65 and 469.78 mg/g, respectively, while adsorption followed second-order rate kinetics for both impregnated carbons. According to the thermodynamic parameters (ΔΗο, ΔSo, ΔGo), the adsorption is a spontaneous, exothermic, and physical process. Fenton-driven experiments conducted at different molar ratios of [H₂O₂]/[BPA] showed efficient degradation of BPA in spent Fe-impregnated carbons up to 82–95%, with traces of hydroxylated products.

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S olubilization of insoluble zinc compounds by zinc solubilizing bacteria (ZSB) and optimization of their growth conditions

Abstract

In this research, the optimum growth conditions for two zinc solubilizing bacteria (ZSB) have been studied for their potential application as bioinoculants to overcome Zn unavailability in soils. For this purpose, a laboratory-scale experiment was carried out to evaluate the zinc solubilizing ability of 80 plant growth promoting bacteria (PGPB) strains isolated from the rhizosphere of barley and tomato plants. To select effective ZSB, isolates were evaluated on Tris-mineral medium supplemented separately with zinc oxide, zinc carbonate, and zinc phosphate at a concentration of 0.1%. Two strains (Agrobacterium tumefaciens and Rhizobium sp.) were selected, based on a clear halo zone around their colonies in the solid medium supplemented with zinc oxide after 10 days of incubation at 29 °C. Results of solubilization at different pH values showed that these strains had solubilization activity in the range of pH 8–10 while no solubilization was observed at pH 6 and 7. The maximum Zn solubilization values were noted at pH 9: 51.4 mg L⁻¹ (Agrobacterium tumefaciens) and 72.1 mg L⁻¹ (Rhizobium sp). According to findings, bacterial growth was affected by different NaCl concentrations under in vitro condition. The salt concentration required for 50% inhibition of absorbance was 2.11 and 2.27% NaCl for Agrobacterium tumefaciens and Rhizobium sp., respectively. The maximum bacterial growth was observed at about 0.8% NaCl concentration.

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Evaluating the effect of biochar addition on the anaerobic digestion of swine manure: application of Py-GC/MS

Abstract

The anaerobic digestion process of swine manure was studied when char was used as supplement for improving performance. The use of pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) was proposed for assessing the organic matter degradation. The assessment on biogas production was carried out using samples of swine manure (SM) supplemented with char in one case and pre-treated by microwave irradiation in the other. This experimental set-up allows for the comparison of the biological degradation observed under these two different configurations and therefore aids in understanding the effect of char particles on the process. Results showed similar performance for both systems, with an average improvement of 39% being obtained in methane production when compared to the single digestion of SM. The analysis of digestate samples by Fourier transform infrared (FTIR) spectroscopy and Py-GC/MS showed improved degradation of proteins, with the Py-GC/MS technique also capable of identifying an increase in microbial-derived material when char was added, therefore highlighting the relevant role of carbon conductive particles on biological systems. Py-GC/MS along with the use of FTIR spectroscopy has proven to be useful tools when evaluating anaerobic digestion.

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Scholar : Molecular Medicine Reports - Volume:18 Number:2

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TABLE OF CONTENTS August-2018 Volume 18 Issue 2

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Cell‑specific histone modifications in atherosclerosis (Review) Wanlin Jiang, Devendra K. Agrawal, Chandra S. Boosani View Abstract ❯
Computational approaches for predicting key transcription factors in targeted cell reprogramming (Review) Guillermo‑Issac Guerrero‑Ramirez, Cesar‑Miguel Valdez‑Cordoba, Jose‑Francisco Islas‑Cisneros, Victor Trevino View Abstract ❯
Efficacy prediction of targeted therapy for gastric cancer: The current status (Review) Wanjing Feng, Xiaodong Zhu View Abstract ❯
microRNA‑183 is involved in the differentiation and regeneration of Notch signaling‑prohibited hair cells from mouse cochlea Wei Zhou, Jintao Du, Di Jiang, Xianren Wang, Kaitian Chen, Haocheng Tang, Xuemei Zhang, Hui Cao, Ling Zong, Chang Dong, Hongyan Jiang View Abstract ❯
Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis Zhe Wang, Yudi Han, Zhaoqing Zhang, Cunfeng Jia, Qiang Zhao, Wei Song, Tao Chen, Yifan Zhang, Xiuhui Wang View Abstract ❯
Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non‑neoplastic mucosa Luoluo Yang, Xun Sun, Xiangwei Meng View Abstract ❯
miR‑339‑5p negatively regulates loureirin A‑induced hair follicle stem cell differentiation by targeting DLX5 Xiangjun Li, Yuqiong Wu, Fangfang Xie, Fengxue Zhang, Saixia Zhang, Jianhong Zhou, Dongfeng Chen, Aijun Liu View Abstract ❯
Inflammatory cytokine profile of co‑cultivated primary cells from the endometrium of women with and without endometriosis Adriana Luckow Invitti, Eduardo Schor, Rafael Martins Parreira, Alexander Kopelman, Gil Kamergorodsky, Giovana Aparecida Gonçalves, Manoel João Batista Castello Girão View Abstract ❯
System analysis of teratozoospermia mRNA profile based on integrated bioinformatics tools Tiancheng Zhang, Jun Wu, Caihua Liao, Zhong Ni, Jufen Zheng, Fudong Yu View Abstract ❯
CXCL9 promotes prostate cancer progression through inhibition of cytokines from T cells Shanfeng Tan, Kai Wang, Fuguang Sun, Yang Li, Yisheng Gao View Abstract ❯
Genes associated with inflammation and the cell cycle may serve as biomarkers for the diagnosis and prognosis of acute myocardial infarction in a Chinese population Jiang Su, Changqing Gao, Rong Wang, Cangsong Xiao, Ming Yang View Abstract ❯
Salvianolic acid B reverses multidrug resistance in nude mice bearing human colon cancer stem cells Piaoting Guo, Jianchao Wang, Wencang Gao, Xia Liu, Shaofei Wu, Boshun Wan, Lei Xu, Yanhua Li View Abstract ❯
Response of hPDLSCs on 3D printed PCL/PLGA composite scaffolds in vitro Caixia Peng, Jinxuan Zheng, Dongru Chen, Xueqin Zhang, Lidi Deng, Zhengyuan Chen, Liping Wu View Abstract ❯
Telomerase reverse transcriptase induced thyroid carcinoma cell proliferation through PTEN/AKT signaling pathway Hao Zhang, Ning Hu View Abstract ❯
Lipid raft‑associated β‑adducin participates in neutrophil migration Chen Yang, Zhefeng Sui, Tingshuang Xu, Wenai Liu, Xiaoguang Wang, Xianlu Zeng View Abstract ❯
Sipi soup inhibits cancer‑associated fibroblast activation and the inflammatory process by downregulating long non‑coding RNA HIPK1‑AS Bingxiu Zhou, Yuanyuan Yu, Lixia Yu, Binfu Que, Rui Qiu View Abstract ❯
Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function Sichao Zhang, Xi Chen, Ichinkhorloo Devshilt, Qi Yun, Cong Huang, Lijun An, Sosorburam Dorjbat, Xin He View Abstract ❯
Low expression of KCNN3 may affect drug resistance in ovarian cancer Xia Liu, Luwei Wei, Bingbing Zhao, Xiangxue Cai, Caihua Dong, Fuqiang Yin View Abstract ❯
The roles of the TLR/NF‑κB signaling pathway in the mutual interactions between the lung and the large intestine Wen Fu, Jing Zhao, Xinglong Liu, Yongxiang Gao, Chuan Zheng View Abstract ❯
miR‑141 inhibits glioma vasculogenic mimicry by controlling EphA2 expression Guoxiong Li, Min Huang, Yingqian Cai, Yiquan Ke, Yuantao Yang, Xinlin Sun View Abstract ❯
Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells Hongtao Sun, Shuiyun Wang, Min Song View Abstract ❯
Screening genes associated with elevated neutrophil‑to‑lymphocyte ratio in chronic heart failure Guoxing Wan, Lihua Ji, Wenbin Xia, Lan Cheng, Yonggang Zhang View Abstract ❯
A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review Minghui Pang, Yijun Liu, Xiaolin Hou, Jialiang Yang, Xuelai He, Nengyi Hou, Peixi Liu, Luo Liang, Junwen Fu, Kang Wang, Zimeng Ye, Bo Gong View Abstract ❯
Curcumin suppresses cardiac fibroblasts activities by regulating the proliferation and cell cycle via the inhibition of the p38 MAPK/ERK signaling pathway Guanhua Fang, Shaoqin Chen, Qiuyu Huang, Liangwan Chen, Dongshan Liao View Abstract ❯
Protective effect of crocin on ultraviolet B‑induced dermal fibroblast photoaging Mingwu Deng, Dong Li, Yichen Zhang, Guangdong Zhou, Wei Liu, Yilin Cao, Wenjie Zhang View Abstract ❯
Grape seed proanthocyanidins protect against streptozotocin‑induced diabetic nephropathy by attenuating endoplasmic reticulum stress‑induced apoptosis Zhaoli Gao, Guangyi Liu, Zhao Hu, Weiwei Shi, Binbin Chen, Peimei Zou, Xianhua Li View Abstract ❯
Physical exercise promotes proliferation and differentiation of endogenous neural stem cells via ERK in rats with cerebral infarction Wei Liu, Wen Wu, Guangyong Lin, Jian Cheng, Yanyan Zeng, Yu Shi View Abstract ❯
Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis Yang Zhang, Hui‑Xia Qiao, Yong‑Tao Zhou, Liang Hong, Ju‑Hui Chen View Abstract ❯
A three‑lncRNA signature for prognosis prediction of acute myeloid leukemia in patients Fangce Wang, Xiaoxue Tian, Jie Zhou, Guangming Wang, Wenlei Yu, Zheng Li, Zhuoyi Fan, Wenjun Zhang, Aibin Liang View Abstract ❯
Autophagy protects bone marrow mesenchymal stem cells from palmitate‑induced apoptosis through the ROS‑JNK/p38 MAPK signaling pathways Yongyi Liu, Ning Wang, Shaokun Zhang, Qingwei Liang View Abstract ❯
Alterations in β‑catenin/E‑cadherin complex formation during the mechanotransduction of Saos‑2 osteoblastic cells Fei‑Fei Li, Bo Zhang, Ji‑Hong Cui, Fu‑Lin Chen, Yin Ding, Xue Feng View Abstract ❯
Comprehensive evaluation of differential lncRNA and gene expression in patients with intervertebral disc degeneration Zhigang Qu, Zhe Quan, Qi Zhang, Zhenyu Wang, Qingxu Song, Xinming Zhuang, Changfeng Fu, Feng Xu, Yadong Liu, Yuanyi Wang, Zheng Wang, Yi Liu View Abstract ❯
Identification and functional analysis of differentially expressed genes associated with cerebral ischemia/reperfusion injury through bioinformatics methods Xiaoli Shao, Wangxiao Bao, Xiaoqin Hong, Huihua Jiang, Zhi Yu View Abstract ❯
miR‑23a downregulation modulates the inflammatory response by targeting ATG12‑mediated autophagy Xiang Si, Daiyin Cao, Juan Chen, Yao Nie, Zhiyi Jiang, Min‑Ying Chen, Jian‑Feng Wu, Xiang‑Dong Guan View Abstract ❯
A novel method to detect the Mexican founder mutation BRCA1 ex9‑12del associated with breast and ovarian cancer using quantitative polymerase chain reaction and TaqMan® probes Denisse Aideé Martínez‑Treviño, Rafael Baltazar Reyes León‑Cachón, Cynthia Villarreal‑Garza, Dione Aguilar Y Méndez, Elisa Aguilar‑Martínez, Hugo Alberto Barrera‑Saldaña View Abstract ❯
Identification of candidate biomarkers and pathways associated with SCLC by bioinformatics analysis Pushuai Wen, Tungamirai Chidanguro, Zhuo Shi, Huanyu Gu, Nan Wang, Tongmei Wang, Yuhong Li, Jing Gao View Abstract ❯
Proteomic profiling for plasma biomarkers of tuberculosis progression Qiuyue Liu, Liping Pan, Fen Han, Baojian Luo, Hongyan Jia, Aiying Xing, Qi Li, Zongde Zhang View Abstract ❯
Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway Zhengwen Zhou, Yue Zhang, Luning Lin, Jianmei Zhou View Abstract ❯
Overexpression of retinoblastoma‑binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3‑kinase/protein kinase B pathway suppression Xiaoxi Jin, Rui Jiang, Yongsheng Xiang, Zhen Fan, Zhiwei Wu, Bo Yang, Lujun Yang, Shanshan Wei, Yan Yang View Abstract ❯
Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway Lin Xu, Xuejun Jiang, Fang Wei, Hongling Zhu View Abstract ❯
miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11 Tianpeng Jiang, Zhi Huang, Shuai Zhang, Weijie Zou, Lei Xiang, Xiaowen Wu, Yaping Shen, Weixin Liu, Zhu Zeng, Ansu Zhao, Shi Zhou, Qingfan Zeng View Abstract ❯
Induction of apoptosis by Bigelovii A through inhibition of NF‑κB activity Fuqin Guan, Yu Shan, Qizhi Wang, Ming Wang, Yu Chen, Min Yin, Fei Liu, Youyi Zhao, Jianhua Zhang, Xu Feng View Abstract ❯
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF‑κB pathway in mouse kupffer cells Bailin Niu, Kun He, Peizhi Li, Jianping Gong, Xiwen Zhu, Shangmin Ye, Zhibing Ou, Guosheng Ren View Abstract ❯
Long noncoding RNA AFAP1‑AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR‑4695‑5p/TCF4‑β‑catenin signaling Rongrui Li, Shichen Liu, Yao Li, Qingxi Tang, Yunchuan Xie, Raosheng Zhai View Abstract ❯
Molecular analysis of Cypriot families with aniridia reveals a novel PAX6 mutation Andreas Syrimis, Nayia Nicolaou, Angelos Alexandrou, Ioannis Papaevripidou, Michael Nicolaou, Eleni Loukianou, Carolina Sismani, Stavros Malas, Violetta Christophidou‑Anastasiadou, George A. Tanteles View Abstract ❯
Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids Ye Zhang, Bingyu Guo, Qiang Hui, Wei Li, Peng Chang, Kai Tao View Abstract ❯
Pioglitazone restores the homocysteine‑impaired function of endothelial progenitor cells via the inhibition of the protein kinase C/NADPH oxidase pathway Junhui Zhu, Yanbo Zhao, Lu Yu, Meihui Wang, Qinfeng Li, Shengjie Xu View Abstract ❯
CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3 Ye Wu, Lei Tian, Yongle Xu, Minhong Zhang, Shengqing Xiang, Jianguo Zhao, Zhenxia Wang View Abstract ❯
Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma through regulation of the EGF‑mediated JAK‑STAT signaling pathway Mingli Duan, Xiaoming Du, Gang Ren, Yongdong Zhang, Yu Zheng, Shuping Sun, Jun Zhang View Abstract ❯
Efficacy of lentivirus‑mediated Drosophila melanogaster deoxyribonucleoside kinase combined with (E)‑5‑(2‑bromovinyl)‑2'‑deoxyuridine or 1‑β‑D‑arabinofuranosylthymine therapy in human keloid fibroblasts Yiqun Sun, Haiyang Jiang, Ming Gu, Xinyu Zheng View Abstract ❯
miRNA‑195 suppresses cell proliferation of ovarian cancer cell by regulating VEGFR2 and AKT signaling pathways Jun Chen View Abstract ❯
miR‑205 targets YAP1 and inhibits proliferation and invasion in thyroid cancer cells Dewei Li, Qiang Wang, Ning Li, Shuilong Zhang View Abstract ❯
Bushen recipe and its disassembled prescriptions inhibit inflammation of liver injury associated with Concanavalin A through Toll‑like receptor 3/9 signaling pathway Hongming Nie, Zhaohe Mei, Rong Wang, Binbin Zhao, Yueqiu Gao, Jianjie Chen, Lingtai Wang View Abstract ❯
Tanshinone IIA regulates colorectal cancer apoptosis via attenuation of Parkin‑mediated mitophagy by suppressing AMPK/Skp2 pathways Lili He, Kebo Gu View Abstract ❯
Increased B cell activating factor is associated with B cell class switching in patients with tuberculous pleural effusion Xin Wang, Kui‑Di Liang, Jun‑Ai Zhang, Gan‑Bin Liu, Zhi Chen, Chen Chen, Ze‑Gang Zhuang, Yu‑Qing Liu, Hou‑Long Luo, Rui Xi Li, Bi‑Ying Zheng, Jun‑Fa Xu View Abstract ❯
Hypoxia induces lactate secretion and glycolytic efflux by downregulating mitochondrial pyruvate carrier levels in human umbilical vein endothelial cells Dong Wang, Qingjie Wang, Gaoliang Yan, Yong Qiao, Boqian Zhu, Bo Liu, Chengchun Tang View Abstract ❯
Reduction in activating transcription factor 4 promotes carbon tetrachloride and lipopolysaccharide/D‑galactosamine‑mediated liver injury in mice Xiaofang Zhao, Hong Zhou, Ying Cheng, Wenjing Yu, Guosong Luo, Chunyan Duan, Fuli Yao, Bin Xiao, Chunhong Feng, Xianming Xia, Mei Wei, Yong Wang, Jing Li, Rongyang Dai View Abstract ❯
Association between age‑related hearing loss and cognitive decline in C57BL/6J mice Yang Dong, Chun‑Rong Guo, Dan Chen, Sheng‑Min Chen, Yinting Peng, Haiyan Song, Jian‑Rong Shi View Abstract ❯
Epithelial‑mesenchymal transition was identified as a potential marker for breast cancer aggressiveness using reverse transcription‑quantitative polymerase chain reaction Ulrich Andergassen, Kristina Schlenk, Udo Jeschke, Harald Sommer, Alexandra Kölbl View Abstract ❯
Effects of microRNA‑210 on the diagnosis and treatment of prostate cancer Yuejun Qu, Wenqiang Huang View Abstract ❯
Upregulation of miR‑122 is associated with cardiomyocyte apoptosis in atrial fibrillation Xiangqun Zhang, Wenli Jing View Abstract ❯
Protective effects of scoparone against ischemia‑reperfusion‑induced myocardial injury Chunfu Wan, Yueyue Wei, Jianguo Ma, Xiaoyong Geng View Abstract ❯
Novel HSPG2 mutations causing Schwartz‑Jampel syndrome type 1 in a Chinese family: A case report Wenjin Yan, Jin Dai, Dongquan Shi, Xingquan Xu, Xiao Han, Zhihong Xu, Dongyang Chen, Huajiang Teng, Qing Jiang View Abstract ❯
Integrated computational biology analysis to evaluate target genes for chronic myelogenous leukemia Yu Zheng, Yu‑Ping Wang, Hongbao Cao, Qiusheng Chen, Xi Zhang View Abstract ❯
Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs Changhwan Ahn, Jong‑Sam Choi, Eui‑Bae Jeung View Abstract ❯
TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling Qing‑Zhi Gu, Abulimiti Nijiati, Xing Gao, Kai‑Liang Tao, Cheng‑Duo Li, Xue‑Peng Fan, Zheng Tian View Abstract ❯
Glucagon‑like peptide‑1 protects mouse podocytes against high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in vitro Jian‑Xia Shi, Qin Huang View Abstract ❯
CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide P. Fallahi, R. Foddis, G. Elia, F. Ragusa, A. Patrizio, S. Benvenga, A. Cristaudo, A. Antonelli, S. M. Ferrari View Abstract ❯
MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R Yongquan Lin, Lihua Rong, Jingrong Zhao, Ronghui Lin, Shuhua Li View Abstract ❯
MicroRNA‑199b promotes cell proliferation and invasion in Wilms' tumour by directly targeting Runt‑related transcription factor 3 Huizhen Zhao, Hailing Zhao, Yongna Zhang, Yuxi Zhou View Abstract ❯
MG‑132 reverses multidrug resistance by activating the JNK signaling pathway in FaDu/T cells Juke Ma, Zhenghua Lv, Xiuxiu Liu, Xianfang Liu, Wei Xu View Abstract ❯
microRNA‑574 inhibits cell proliferation and invasion in glioblastoma multiforme by directly targeting zinc finger E‑box‑binding homeobox 1 Youyan Mao, Fangmeng Wei, Chenghong Wei, Chengjun Wei View Abstract ❯
Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines Yuanxin Zhang, Yakun Ge, Xie Ping, Ming Yu, Dawei Lou, Wei Shi View Abstract ❯
B7‑H1‑mediated immunosuppressive properties in human mesenchymal stem cells are mediated by STAT‑1 and not PI3K/Akt signaling In Keun Jang, Hyun Joo Jung, O Kyu Noh, Doo‑Hoon Lee, Kwang Chul Lee, Jun Eun Park View Abstract ❯
Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice Tianxiang Geng, Xi Chen, Mengxue Zheng, Haochen Yu, Shuai Zhang, Shouxuan Sun, Haohui Guo, Qunhua Jin View Abstract ❯
Protective effect of Letinous edodes foot peptides against ethanol‑induced liver injury in L02 cells Lin Ma, Chun‑Yan Huo, Xiao‑Yu Zhang, Chen‑Qiang Qin, Di‑Feng Ren, Jun Lu View Abstract ❯
Oxidative stress modulates the expression of toll‑like receptor 3 during respiratory syncytial virus infection in human lung epithelial A549 cells Min‑Min Wang, Min Lu, Chuan‑Long Zhang, Xuan Wu, Jing‑Xian Chen, Wei‑Wei Lv, Tao Sun, Huan Qiu, Sheng‑Hai Huang View Abstract ❯
MicroRNA‑655 inhibits cell proliferation and invasion in epithelial ovarian cancer by directly targeting vascular endothelial growth factor Ziling Zhao, Shuna Yang, Yan Cheng, Xiuhua Zhao View Abstract ❯
The effect of Mg‑2Zn‑0.5Nd alloy on the mTOR signalling pathway in L6 cells Wei Lu, Lei Guo, Tianlong Jiang, Shenghui Ni, Yuyan Zhao View Abstract ❯
[Corrigendum] Construction of a lentiviral vector containing shRNA targeting ADAM17 and its role in attenuating endotoxemia in mice Bing He, Xiaoou Li, Tuo Hu, Wenjing Lian, Mingxia Zhang View Abstract ❯
[Corrigendum] microRNA‑181a‑5p functions as an oncogene in renal cell carcinoma Yulin Lai, Liwen Zhao, Jia Hu, Jing Quan, Peijie Chen, Jinling Xu, Xin Guan, Yongqing Lai, Liangchao Ni View Abstract ❯
Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway Chengzhi Fang, Lili Xie, Chunmei Liu, Chunhua Fu, Wei Ye, Hong Liu, Binghong Zhang View Abstract ❯
MicroRNA expression profiles identify biomarkers for predicting the response to chemoradiotherapy in rectal cancer Binbin Du, Xiaoying Wang, Dewang Wu, Tao Wang, Xiongfei Yang, Jiankai Wang, Xinlong Shi, Lingjuan Chen, Weisheng Zhang View Abstract ❯
Regulatory effects of microRNA‑184 on osteosarcoma via the Wnt/β‑catenin signaling pathway Zhenguang Du, Fusheng Li, Liangliang Wang, Hai Huang, Shaonian Xu View Abstract ❯
Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats Dandan Song, Xuelei Liu, Yugang Diao, Yingjie Sun, Guangjie Gao, Tiezheng Zhang, Keyan Chen, Ling Pei View Abstract ❯
Effect of survivin downregulation by simvastatin on the growth and invasion of salivary adenoid cystic carcinoma Wen‑Yan Cai, Ying Zhuang, Fei Yan, Ting Li, Wen‑Ting Song, Jin‑Hu Sun View Abstract ❯
HBx gene transfection affects the cycle of primary renal tubular epithelial cells through regulating cyclin expression Wenlun Han, Meiliang Luo, Mengying He, Yunyun Zhu, Yu Zhong, Huideng Ding, Gang Hu, Liansheng Liu, Qin Chen, Ying Lu View Abstract ❯
Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium Nan Guo, Nan Zhang, Liqiu Yan, Zheng Lian, Jiawang Wang, Fengfeng Lv, Yunfei Wang, Xufen Cao View Abstract ❯
Detection of dysregulated competing endogenous RNA modules associated with clear cell kidney carcinoma Hong Wang, Dahua Xu, Huiying Huang, Ying Cui, Chunhua Li, Chunrui Zhang, Shengnan Guo, Lining Zhang, Xiaomu Xu, Jiankai Xu, Jianping Lu, Liqiang Wang, Kongning Li View Abstract ❯
Interaction with adipocytes induces lung adenocarcinoma A549 cell migration and tumor growth Fan-Fan Li, Hang Zhang, Jing-Jing Li, Ya-Nan Cao, Xiang Dong, Cong Gao View Abstract ❯
Antioxidants retard the ageing of mouse oocytes Yexing Xian, Lifeng Liang, Shutao Qi, Yingjun Xie, Bing Song, Shuming Ouyang, Yuhuan Xie, Xiaofang Sun, Weihua Wang View Abstract ❯
Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α Bing Liu, Lili Xu, Xinming Yu, Wei Li, Xiaozhi Sun, Shun Xiao, Mingjin Guo, Haofu Wang View Abstract ❯
Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy Yingchun Qiao, Xixi Tian, Li Men, Shengyu Li, Yufeng Chen, Meiting Xue, Yahui Hu, Pengfei Zhou, Guangfeng Long, Yue Shi, Ruiqing Liu, Yunde Liu, Zhi Qi, Yujie Cui, Yanna Shen View Abstract ❯
Differentiation of umbilical cord mesenchymal stem cells into hepatocytes in comparison with bone marrow mesenchymal stem cells Ya‑Bin Yu, Yan Song, Ya Chen, Feng Zhang, Fu‑Zhen Qi View Abstract ❯
Application of 460 nm visible light for the elimination of Candida albicans in vitro and in vivo Chuan Wang, Zhiyin Yang, Yinbo Peng, Yuanyuan Guo, Min Yao, Jiying Dong View Abstract ❯
Whole‑exome sequencing analysis of products of conception identifies novel mutations associated with missed abortion Meng Fu, Sha Mu, Chunyan Wen, Shufang Jiang, Lin Li, Yuanguang Meng, Hongmei Peng View Abstract ❯
Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis Takumi Kawaguchi, Dan Nakano, Tetsuharu Oriishi, Takuji Torimura View Abstract ❯
YC‑1 reduces inflammatory responses by inhibiting nuclear factor‑κB translocation in mice subjected to transient focal cerebral ischemia Wei‑Ting Lee, Shih‑Huang Tai, Yu‑Wen Lin, Tian‑Shung Wu, E‑Jian Lee View Abstract ❯
Expression of vitamin D receptor in bronchial asthma and its bioinformatics prediction Lishen Shan, Xinyuan Kang, Fen Liu, Xuxu Cai, Xiaohua Han, Yunxiao Shang View Abstract ❯
TIMP‑3 suppresses the proliferation and migration of SMCs from the aortic neck of atherosclerotic AAA in rabbits, via decreased MMP‑2 and MMP‑9 activity, and reduced TNF‑α expression Huan Zhai, Xun Qi, Zixuan Li, Wei Zhang, Chenguang Li, Lu Ji, Ke Xu, Hongshan Zhong View Abstract ❯
Antitumor effects of Xi Huang pills on MDA‑MB‑231 cells in vitro and in vivo Wenxian Zheng, Shuyan Han, Shantong Jiang, Xiran He, Xiaohong Li, Huirong Ding, Minhua Cao, Pingping Li View Abstract ❯
Label‑free quantitative proteomics and bioinformatics analyses of alcoholic liver disease in a chronic and binge mouse model Yu Zhang, Cheng Zhan, Genwen Chen, Jianyong Sun View Abstract ❯
Epigallocatechin gallate improves airway inflammation through TGF‑β1 signaling pathway in asthmatic mice Lishen Shan, Xinyuan Kang, Fen Liu, Xuxu Cai, Xiaohua Han, Yunxiao Shang View Abstract ❯
Characteristics and multi‑lineage differentiation of bone marrow mesenchymal stem cells derived from the Tibetan mastiff Shuang Zhang, Chenqiong Zhao, Shi Liu, Yufeng Wang, Yuhua Zhao, Weijun Guan, Zhiqiang Zhu View Abstract ❯
C5a aggravates dysfunction of the articular cartilage and synovial fluid in rats with knee joint immobilization Wei Lu, Lin Wang, Jing Yao, Chunxin Wo, Yu Chen View Abstract ❯
Amplification of bacterial genomic DNA from all ascitic fluids with a highly sensitive polymerase chain reaction Hirayuki Enomoto, Shin‑Ichi Inoue, Akio Matsuhisa, Yoshinori Iwata, Nobuhiro Aizawa, Yoshiyuki Sakai, Ryo Takata, Naoto Ikeda, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Kazunori Yoh, Yuho Miyamoto, Noriko Ishii, Yukihisa Yuri, Akio Ishii, Tomoyuki Takashima, Hiroki Nishikawa, Hiroko Iijima, Shuhei Nishiguchi View Abstract ❯
Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells Yan Yu, Wanting Li, Liqin Ren, Chunyan Yang, Dongze Li, Xin Han, Yeying Sun, Changjun Lv, Fang Han View Abstract ❯
Effect of electric stimulation on human chondrocytes and mesenchymal stem cells under normoxia and hypoxia Bettina Hiemer, Martin Krogull, Thomas Bender, Josefin Ziebart, Simone Krueger, Rainer Bader, Anika Jonitz‑Heincke View Abstract ❯
N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes Zuheng Liu, Jinghai Hua, Wanqiang Cai, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu View Abstract ❯
Identification of differentially expressed genes associated with asthma in children based on the bioanalysis of the regulatory network Chunyan Wang, Hengtao Li, Lanfang Cao, Genzai Wang View Abstract ❯
Identification of a noncoding RNA‑mediated gene pair‑based regulatory module in Alzheimer's disease Lin Yu, Shi Qian, Sun Wei View Abstract ❯
Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide‑induced intestinal injury Ying Xiong, Kai‑Xue Li, Hong Wei, Lu Jiao, Shao‑Yong Yu, Li Zeng View Abstract ❯
Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer Yu Jiang, Gang Liu, Li Zhang, Sheng Cheng, Chun Luo, Yang Liao, Shuliang Guo View Abstract ❯
Next‑generation sequencing‑based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, Her‑2 and TP53 mutations in patients with non‑small cell lung cancer Changwen Jing, Xuhua Mao, Zhuo Wang, Kejing Sun, Rong Ma, Jianzhong Wu, Haixia Cao View Abstract ❯
Recombinant club cell protein 16 (CC16) ameliorates cigarette smoke‑induced lung inflammation in a murine disease model of COPD Min Pang, Hong‑Yan Liu, Ting Li, Dan Wang, Xiao‑Yun Hu, Xin‑Ri Zhang, Bao‑Feng Yu, Rui Guo, Hai‑Long Wang View Abstract ❯
Inhibitory effects of TGP on KGF‑induced hyperproliferation of HaCaT cells via suppression of the p38 MAPK/NF‑κB p65 pathway Weirong Pang, Xiaoming Qi, Chunmei Cao, Shuosheng Zhang View Abstract ❯
PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways Eun Ji Ryu, Dae Won Kim, Min Jea Shin, Hyo Sang Jo, Jung Hwan Park, Su Bin Cho, Chi Hern Lee, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Duk‑Soo Kim, Sung‑Woo Cho, Yong‑Jun Cho, Eun Jeong Sohn, Ora Son, Keun Wook Lee, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Choi View Abstract ❯
miR‑214 mediates vascular inflammation and apoptosis via PTEN expression Mingliang Wang, Min Liu, Ting Ni, Qiliang Liu View Abstract ❯
Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway Hong‑Yu Meng, De‑Cheng Shao, Han Li, Xiao‑Dan Huang, Guang Yang, Bing Xu, Hai‑Yun Niu View Abstract ❯
Identification of open chromosomal regions and key genes in prostate cancer via integrated analysis of DNase‑seq and RNA‑seq data Xin Wei, Lili Yu, Xuefei Jin, Lide Song, Yanting Lv, Yuping Han View Abstract ❯
BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy Xun Wang, Shuai Wang, Yuan Zhou, Halmurat Obulkasim, Zhi‑Heng Zhang, Bo Dai, Wei Zhu, Xiao‑Lei Shi View Abstract ❯
Aclidinium bromide inhibits the growth and metastasis of gastric cancer MKN‑28 cells via the PI3K signaling pathway Yuanzhi Wang, Ping Cui, Jingjing Liu, Hongxia Wu, Jun Ma View Abstract ❯
LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR‑4310/LGR5/Wnt/β‑catenin signaling pathway Niancai Jing, Tao Huang, Huaiyu Guo, Jili Yang, Mingjing Li, Zhuo Chen, Yue Zhang View Abstract ❯
Pyroptosis, a novel mechanism implicated in cataracts Xin Jin, Hao Jin, Yan Shi, Yiyuan Guo, Hong Zhang View Abstract ❯
MicroRNA‑326 inhibits endometrial fibrosis by regulating TGF‑β1/Smad3 pathway in intrauterine adhesions Jing Ning, Hongtao Zhang, Hongwei Yang View Abstract ❯
Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression Hai‑Yan Wei, Rui Feng, Hua Shao, Bin Feng, Hong‑Qiang Liu, Jin‑Long Men, Wei Zou View Abstract ❯
Captopril inhibits calpain‑mediated apoptosis of myocardial cells in diabetic rats and improves cardiac function Li‑Ya Dong, Li‑Ping Yao, Jing Zhao, Ke‑Ke Jin, Xiao‑Xiao Qiu View Abstract ❯
The close association between IL‑12Rβ2 and p38MAPK, and higher expression in the early stages of NSCLC, indicates a good prognosis for survival Zhaoguo Liu, Weilin Yang, Shibin Yang, Kaican Cai View Abstract ❯
Thymosin β4 promotes endothelial progenitor cell angiogenesis via a vascular endothelial growth factor‑dependent mechanism Yanbo Zhao, Jiale Song, Xukun Bi, Jing Gao, Zhida Shen, Junhui Zhu, Guosheng Fu View Abstract ❯
CNOT1 is involved in TTP‑mediated ICAM‑1 and IL‑8 mRNA decay Jia‑Xin Shi, Jia‑Shu Li, Rong Hu, Xin‑Cheng Zhao, Cheng‑Cheng Liang, Xiao‑Min Li, Hong Wang, Yi Shi, Xin Su View Abstract ❯
miR‑590‑5p suppresses osteosarcoma cell proliferation and invasion via targeting KLF5 Wei Cai, Yong Xu, Jian Yin, Wenshan Zuo, Zhen Su View Abstract ❯
Intraperitoneal oxaliplatin administration inhibits the tumor immunosuppressive microenvironment in an abdominal implantation model of colon cancer Hong‑Feng Gou, Lei Zhou, Jia Huang, Xin‑Chuan Chen View Abstract ❯
The effects of hyperoxia liquid regulate cardiopulmonary bypass‑induced myocardial damage through the Nrf2‑ARE signaling pathway Xiaochun Ma, Bin Hu, Chengwei Zou, Aiguo Han, Zhenqiang Xu, Tao Zhang, Wancheng Yu View Abstract ❯
Protective properties of spliced X box binding protein 1 in ozone‑induced spinal cord neuronal death Yun Li, Xu Zhao, Xiaowen Lin, Xuejun Zhao, Juntian Xie, Tao Sun, Zhijian Fu View Abstract ❯
JAG1 loss‑of‑function mutations contributed to Alagille syndrome in two Chinese families Erge Zhang, Yuejuan Xu, Yongguo Yu, Sun Chen, Yu Yu, Kun Sun View Abstract ❯
Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation Qiang Liu, Qingshan Wang, Haibin Li View Abstract ❯
MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation Yan Jin, Qiuyun Tu, Min Liu View Abstract ❯
Polymorphism rs7521584 in miR‑429 is associated with the severity of atrophic gastritis in patients with Helicobacter pylori infection Toshimi Otsuka, Tomomitsu Tahara, Masakatsu Nakamura, Wu Jing, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Tomoyuki Shibata, Tomiyasu Arisawa View Abstract ❯
Montelukast inhibits RANKL‑induced osteoclast formation and bone loss via CysLTR1 and P2Y12 Ju‑Hee Kang, Hyungsik Lim, Dong‑Seok Lee, Mijung Yim View Abstract ❯
Urinary C‑X‑C motif chemokine 13 is a noninvasive biomarker of antibody‑mediated renal allograft rejection Dajin Chen, Jian Zhang, Wenhan Peng, Chunhua Weng, Jianghua Chen View Abstract ❯
MicroRNA‑485 targets MACC1 and inhibits cervical cancer cell proliferation and invasion Shumei Wang, Yaqi Zhang, Shunping Yuan, Xiaoling Ji View Abstract ❯
Association study of frameshift and splice variant polymorphisms with risk of idiopathic recurrent pregnancy loss Hyun Ah Lee, Eun Hee Ahn, Ji Hyang Kim, Jung Oh Kim, Chang Soo Ryu, Jeong Yong Lee, Sung Hwan Cho, Woo Sik Lee, Nam Keun Kim View Abstract ❯
Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice Hu‑Nan Sun, Li Feng, Ai‑Guo Wang, Jing‑Yu Wang, Lei Liu, Mei‑Hua Jin, Gui‑Nan Shen, Cheng‑Hao Jin, Dong‑Soek Lee, Tae‑Ho Kwon, Yu‑Dong Cui, Dae‑Yeul Yu, Ying‑Hao Han View Abstract ❯
Downregulation of microRNA‑660 inhibits cell proliferation and invasion in osteosarcoma by directly targeting forkhead box O1 Peng Zhang, Haifeng Gao, Qing Li, Xinlei Chen, Xifa Wu View Abstract ❯
Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family Qasem Abdallah, Ibrahim Al‑Deeb, Ammar Bader, Fayez Hamam, Kamel Saleh, Amin Abdulmajid View Abstract ❯
Liraglutide improves cognitive impairment via the AMPK and PI3K/Akt signaling pathways in type 2 diabetic rats Ying Yang, Hui Fang, Gang Xu, Yanfeng Zhen, Yazhong Zhang, Jinli Tian, Dandan Zhang, Guyue Zhang, Jing Xu View Abstract ❯
HAUS8 regulates RLR‑VISA antiviral signaling positively by targeting VISA Tian‑Sheng He, Tian Chen, Dan‑Dan Wang, Liang‑Guo Xu View Abstract ❯
The NRF2‑PGC‑1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, synoviolin, in a cecal ligation/perforation‑induced septic mouse model Yusuke Ishida, Hidetoshi Fujita, Satoko Aratani, Miyuki Chijiiwa, Noboru Taniguchi, Maho Yokota, Yukihiko Ogihara, Naomi Uoshima, Fumiaki Nagashima, Hiroyuki Uchino, Toshihiro Nakajima View Abstract ❯
Methylation profiles of miR34 gene family in Vietnamese patients suffering from breast and lung cancers Vo Thi Thuong Lan, Ho Van Son, Vu Lan Trang, Nguyen Thu Trang, Nguyen Thi Phuong, Nguyen Linh Toan, Pham Anh Thuy Duong View Abstract ❯
Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis Sirikul Kulanuwat, Prapaporn Jungtrakoon, Watip Tangjittipokin, Pa‑Thai Yenchitsomanus, Nattachet Plengvidhya View Abstract ❯
miR‑30a‑5p inhibits the proliferation, migration and invasion of melanoma cells by targeting SOX4 Erbiao Liu, Xiyan Sun, Jinping Li, Chao Zhang View Abstract ❯
Assessment of the effects of prostaglandins on myometrial and leiomyoma cells in vitro through microRNA profiling Hwi Gon Kim, Ga Young Jung, Seung Bin Park, Yeon Jean Cho, Myoungseok Han View Abstract ❯
Effects of constrained dynamic loading, CKIP‑1 gene knockout and combination stimulations on bone loss caused by mechanical unloading Biao Han, Shu‑Ping Wei, Xin‑Chang Zhang, Hao Li, Yu Li, Rui‑Xin Li, Kairen Li, Xi‑Zheng Zhang View Abstract ❯
[Corrigendum] Differences in atrial fibrillation‑associated proteins between the left and right atrial appendages from patients with rheumatic mitral valve disease: A comparative proteomic analysis Hai Liu, Guangxian Chen, Hongsheng Zheng, Han Qin, Mengya Liang, Kangni Feng, Zhongkai Wu View Abstract ❯

20-22 September, 2018, Metropolitan Hotel, Athens, Greece 23nd World Congress on Advances in Oncology & 22th International Symposium on Molecular Medicine 18-19 September 2018, Pre-Congress Workshop: 'MicroRNA Analysis'

28-30 March, 2019, Tawana Hotel, Bangkok, Thailand 23 rd International Symposium on Molecular Medicine

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