Esthetic and functional result of crooked nose treatment; internal microperforating osteotomy and subtotal septal reconstruction

Abstract

Crooked nose is mostly characterized by a deviation of both the bone and the cartilaginous parts of the nose. In order to obtain proper functional and improved esthetic results, both of these parts have to be corrected. The objective of this study is to evaluate the esthetical and the functional outcomes following correction procedures of the bone pyramid through internal microperforating technique and the cartilaginous part through subtotal septal reconstruction. The medical records of 158 patients who have undergone through primary septorhinoplasty for crooked nose treatment during the period of 21 June 2016 and 31 July 2017 have been reviewed. Functional results have been evaluated using the Nasal Obstruction Symptom Evaluation (NOSE) scores and the esthetical results through Rhinoplasty Outcome Evaluation (ROE) scores. The observation times have been arranged preoperatively as 6 months–1 year (group 1) and 1–2 years (group 2). Septorhinoplasty procedure has been performed on 158 patients with crooked noses. Out of this number, 104 of the patients (65.8%) were women and 54 were men (34.2%). The average age of the patients was 31.59 (9.3%), all of who have undergone this procedure. There was a significant improvement (P < 0.001) in the NOSE and the ROE scores of group 1 and group 2, which was statistically significant. There was no difference between group 1 and group 2. In crooked nose treatment, correction of the deviated bone pyramid using internal microperforating osteotomy and correction of the severely deviated septum using subtotal septal reconstruction yield improved functional and esthetic results.

Level of Evidence: Level V, therapeutic study.

https://ift.tt/2pZw2zs

Postmortem Analysis of Vitreous Humor For Detection of Antemortem Disorders in Glucose Metabolism. An Old Method Revisited

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0752-0028

It has been estimated that 15% up to one third of cases of deaths due to diabetic ketoacidosis occur in individuals with so far unknown diabetes. Moreover, cardiac arrhythmias that occur during nocturnal hypoglycaemia include bradycardia and ectopics that may provoke lethal arrhythmias. As postmortem capillary glucose concentrations have no diagnostic value, the postmortem forensic proof of hyperglycaemia or hypoglycaemia remains a challenge. The established but rarely applied method of postmortem determination of glucose and lactate in vitreous humor with or without calculation of the sum formula of Traub could provide reliable exclusion or proof of severe antemortem disorders in glucose metabolism. To date, diagnostic puncture of vitreous humor is more established for the postmortem detection of diabetic ketoacidosis than for the exclusion or proof of lethal hypoglycaemia. Vitreous humor is protected from postmortem degradation and contamination due to its isolated localization. The autolytic process in vitreous humor is considerably delayed compared to blood or liquor. In vitreous humor also the triggering agent of hypoglycaemia (insulin, insulin analogues) is easier to be detected than in blood since insulins are very unstable in postmortem blood. Furthermore, parameters of long term glycaemic control such as 1,5-anhydroglucitol, HbA1c and fructosamine can be determined in vitreous humor. However, limitations and interference factors of this method should be carefully considered. So far, clinical diabetology has taken no broad notice of this useful forensic procedure.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2CvDVEf

A 12-day-old Male With a “Skin Tag” on the Chin: Answer

No abstract available

https://ift.tt/2PdwLeI

ALK Gene Fusions in Epithelioid Fibrous Histiocytoma: A Study of 14 Cases, With New Histopathological Findings

Abstract: Previous studies showed that ALK is often positive in epithelioid fibrous histiocytoma (EFH). Two cases of EFH with ALK gene fusions have been recorded. Our objective was to study a series of EFH to present histopathological variations of EFH, identify novel ALK gene fusions, and determine whether there is a correlation between histopathological features and particular gene. We investigated 14 cases of EFH, all ALK immunopositive. The cases were assessed histopathologically as well as for ALK and TFE-3 rearrangements using FISH and ALK gene fusions using next-generation sequencing. The analysis of the sequencing results was performed using the Archer Analysis software (v5; ArcherDX Inc). The study group consisted of 8 female and 6 male patients, ranging in age from 18 to 79 years (mean 42 years; median 37.5 years). All presented with a solitary lesion. Microscopically, most lesions were polypoid and composed of epithelioid cells with ample cytoplasm. In addition, a variable number of bi-, tri-, or multinucleated, spindled, multilobated, cells with eccentric nuclei, cells with nuclear pseudoinclusions, mucinous, and grooved cells were admixed. In 5 cases, the predominant epithelioid cell component consisted of rather small cells, whereas spindled cells dominated in 3 cases. Of these, 2 lesions were composed rather of pale eosinophilic to clear cells, occasioning a resemblance to PEComa or leiomyoma. Immunohistochemically, all cases expressed ALK and 11 were positive for TFE-3. The break apart test for ALK was positive in 11 cases, whereas specimens from the remaining 3 cases were not analyzable. ALK genes fusions were found in all but 3 cases and included SQSTM1-ALK (3), VCL-ALK (3), TMP3-ALK (2), PRKAR2A-ALK (1), MLPH-ALK (1), and EML4-ALK (1). No correlation between histological features and type of ALK fusion was found. TFE-3 break apart test was negative. It is concluded that ALK-immunopositive EFH shows ALK gene fusions that involve various protein-coding genes, implicated in a variety of biological processes. Rare variants of EFH rather consist of spindled "non-epithelioid" cells.

https://ift.tt/2PKNOSs

A New, Firm, Solitary Nodule in a Patient With HIV/AIDS: Challenge

No abstract available

https://ift.tt/2Pd0owS

A Comparison of the Histopathologic Growth Patterns Between Non–Merkel Cell Small Round Blue Cell Tumors and Merkel Cell Carcinoma

Background: Merkel cell carcinoma (MCC) is a rare neuroendocrine cutaneous malignancy that shares cytologic, histopathologic, and immunohistochemical features with other small round blue cell (SRBC) tumors. Although the trabecular pattern is anecdotally associated with MCC, objective data are lacking. Methods: This was a retrospective institutional review board–approved observational study conducted on microscopic images of 79 MCCs and 74 other SRBC tumors (desmoplastic small round cell tumor, primitive neuroectodermal tumor, neuroblastoma, embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma, synovial sarcoma, carcinoid, metastatic small cell lung cancer, non-Hodgkin small cell lymphoma, retinoblastoma, medulloblastoma, nephroblastoma, small cell osteosarcoma, and round cell liposarcoma). An expert dermatopathologist evaluated blinded and randomized microscopic specimens and recorded histologic patterns (diffuse, infiltrative, large anastomosing nests, small islands, any trabecular, focal trabecular, mixed trabecular, and predominately trabecular). Results: Trabecular features were identified in over 72% of MCCs but only rarely in non-MCC SRBC tumors. The presence of any amount of a trabecular pattern favored a diagnosis of MCC over SRBC tumors with a sensitivity of 72.2% and a specificity of 87.8%. If "any" and "focal" trabecular patterns were discounted, specificity rose to 93.2%. Conclusion: The presence of a trabecular pattern helps to differentiate MCC from other SRBC tumors, and specificity approaches that achieved with immunostaining.

https://ift.tt/2PIAcHv

Malignant Melanoma With Massive Crust Mimicking a Cutaneous Horn: An Unexpected Finding

No abstract available

https://ift.tt/2P8MCev

Granulomatous Rosacea Versus Lupus Miliaris Disseminatus Faciei—2 Faces of Facial Granulomatous Disorder: A Clinicohistological and Molecular Study

Abstract: Granulomatous rosacea (GR) and lupus miliaris disseminatus faciei (LMDF) are 2 forms of facial granulomatous diseases. Although they show some morphological overlap, they have distinct clinical presentation. This study was performed to demonstrate the clinical and histological features of GR and LMDF and to establish their relationship to tuberculous etiology by molecular technique. All the cases of GR (n = 20) and LMDF (n = 10) diagnosed on skin biopsy over the past 6 years were reviewed along with their clinical detail. Polymerase chain reaction (PCR) was performed using primers specific for Mycobacterium tuberculosis. The mean age of patients with GR was 45 years 10 months (range 18–75 years) as compared to 33 years 5 months (range 18–57 years) in patients with LMDF. The GR cases comprised 13 men and 7 women patients, whereas all 10 LMDF cases were seen in men. GR cases had papular lesion over an erythematous base on face, whereas LMDF cases had papular/nodular/nodulocystic lesions on the face and neck. Histologically, GR cases showed small granulomas without necrosis in a background of variable lymphoid infiltrate and dilated capillaries, whereas LMDF showed large granulomas with caseous necrosis and minimal inflammation. Five cases (25%) of GR showed degenerating Demodex folliculorum mites. No case of GR or LMDF showed positivity for mycobacterial polymerase chain reaction. Despite some similarities, GR and LMDF show distinct clinical and histological features. Thus, LMDF is a distinct clinicopathological entity separate from the GR, with different etiopathogenesis. However, none of the conditions are related to a tuberculous etiology.

https://ift.tt/2PGUW28

Pustular Eruption After Cocaine Use: Answer

No abstract available

https://ift.tt/2P57TGb

Childhood Phimosis Secondary to Lichen Sclerosus: Is There a Spatial Pattern of Histopathological Changes?

Introduction: The accurate histopathological diagnosis of the phimotic prepuce is indispensable because early diagnosis, treatment, and close follow-up are crucial in genital dermatosis such as lichen sclerosus (LS). This study analyzes the histopathological spectrum of childhood phimosis with special emphasis on LS. We also highlight a peculiar pattern of histopathological evolution in LS, prepuce. Material and methods: The histopathology slides of all the pediatric preputial circumcision specimens performed for the indication of pathological phimosis (n = 43) during the study period (2012–2017) were analyzed. Eight histopathological features viz. hyperkeratosis, hypergranulosis, epidermal atrophy, acanthosis, dermoepidermal cleft, upper dermal edema and homogenization, mid dermal lymphocytic band, and interface dermatitis were studied in each case, separately in inner preputial surface, tip, and outer preputial surface. On the basis of evolution of the disease and histopathological features, the lesions of LS were classified into early, established, and advanced. Result: LS was found in 32 cases, whereas 11 cases showed nonspecific inflammation and fibrosis. The upper dermal homogenization (n = 29), dermoepidermal cleft (n = 28), and mid dermal band (n = 27) were the commonest histopathological changes. The established and advanced changes were confined to the inner preputial surface (n = 31), and the outer preputial skin surface was unaffected in all the cases. A peculiar histopathological evolution pattern was seen with established or advanced lesions, early lesion, and normal histology on the inner preputial surface, mucocutaneous junction, and outer preputial skin, respectively. Conclusions: LS is a common cause of childhood phimosis. It shows a peculiar histopathological evolution that mandates the thorough analysis of inner mucosal surface.

https://ift.tt/2PJIVJe

Cutaneous Atypical Neurofibroma: A Case Report and Review of Literature

No abstract available

https://ift.tt/2P9eT4I

Subconjunctival Herniation of Fat Does Not Demonstrate Loss of RB Gene Expression

No abstract available

https://ift.tt/2PGUIrO

Progressive, Painful Erosions of the Face, Neck, and Lips: Challenge

No abstract available

https://ift.tt/2P8T3OO

Case Report of Myeloid Sarcoma Masquerading as In-Transit Metastasis at a Previous Melanoma Site: Avoiding a Diagnostic Pitfall

Abstract: Myeloid sarcoma is a rare extramedullary hematologic malignancy. Accurate and timely diagnosis may be challenging because myeloid sarcoma is known to mimic solid tumors, including hepatobiliary, nasopharyngeal, and breast carcinomas. We report a case of myeloid sarcoma that developed in the primary tumor lymphatic drainage field of a previously treated intermediate-thickness cutaneous melanoma, clinically and radiographically mimicking an in-transit metastasis, in a patient with myelodysplastic syndrome. The diagnosis of myeloid sarcoma was achieved after surgical excision of the mass and pathological examination that included extensive immunohistochemical studies. Awareness of such an unusual clinical presentation can help reduce diagnostic delay and ensure that adequate tissue is obtained for pathological examination and ancillary studies that are critical for accurate diagnosis and appropriate patient management.

https://ift.tt/2PJXooP

Pigmented Lesions of the Nail Unit

Abstract: Pigmented lesions of the nail unit are commonly encountered in the clinical setting. Yet, they often present a unique challenge to clinicians because of a broad differential diagnosis or unfamiliarity with clinical and histopathologic features. A wide variety of causes exist ranging from benign lesions such as subungual hemorrhage to malignant lesions such as subungual melanoma. Identifying the underlying cause is key to appropriate management and follow-up in these patients. Although emerging clinical tools such as dermoscopy can be very useful in evaluation of these lesions, histopathologic analysis remains the gold standard. In this review, we discuss and provide a summary of important clinical and histopathological concepts of pigmented lesions of the nail unit with special focus on longitudinal melanonychia, melanotic macule, melanocytic nevus, subungual melanoma, along with discussion of some nonmelanocytic lesions.

https://ift.tt/2P9XDfx

Dual-Positive CD4/CD8 Primary Cutaneous Peripheral T-Cell Lymphoma Previously Classified as Mycosis Fungoides a Tumor D'Emblée

Abstract: Cutaneous peripheral T-cell lymphoma, not otherwise specified represents a "waste basket" of all cases that cannot be put into another of the categories of mature cutaneous T-cell lymphoma. Previously, the sudden multifocal development of cutaneous CD4+ tumors without preceding a patch or plaque stage was classified as d'emblée form of mycosis fungoides (MF). Currently, the term "MF" reserved only for the classic Alibert–Bazin type characterized by the evolution of patches, plaques, and tumors or for variants showing a similar clinical course. The authors describe a 75-year-old white woman who presented with a solitary skin tumor in the right supraclavicular region, with no lymph node or systemic involvement. Local external beam radiation treatment resulted in a complete response. The patient relapsed after 5 months with new tumors in the left neck and left upper chest. Biopsy of the lesions showed a dermal infiltrate of atypical small- to medium-sized T-lymphocytes, and immunohistochemical staining showed coexpression of CD4/CD8 in a subset of these cells, which was confirmed with flow cytometry of the tumor. Although the patient had no preceding patch or plaque stage, the authors herein report this extremely rare case of CD4/CD8 dual-positive peripheral T-cell lymphoma, not otherwise specified presented as MF d'emblée and discuss the seldom similar cases published previously.

https://ift.tt/2PGUssQ

A New, Firm, Solitary Nodule in a Patient With HIV/AIDS: Answer

No abstract available

https://ift.tt/2P57SlB

Bowen Disease With Sebaceous Differentiation: A Case Report and Immunohistochemical Analysis of Adipophilin and Cytokeratin 1

Abstract: Bowen disease with sebaceous differentiation has been rarely documented to date. Here, we present a case of Bowen disease with sebaceous differentiation. A 67-year-old man presented with a 6.0 × 3.5 cm erythematous plaque adjacent to a 7.0 × 3.0 cm erythematous plaque on his left abdomen. Dermoscopy revealed yellow structureless areas and dotted vessels on a pink homogenous background in addition to surface scales. Histopathological examination of the upper erythematous plaque showed parakeratosis and acanthosis with proliferation of atypical keratinocytes in the epidermis. Some of the atypical cells had large and hyperchromatic nuclei. Histopathological examination of the lower erythematous plaque showed tumor nests extending from the epidermis. Tumor nests with hyperchromatic and atypical cells had vacuolated cells. The diagnosis of Bowen disease with sebaceous differentiation was made. Immunohistochemistry revealed a positive reaction for cytokeratin 1 (CK1) in tumor cells of Bowen disease and a negative reaction for CK1 in tumor cells with the sebaceous differentiation, whereas immunohistochemistry revealed no apparent adipophilin-positive granules in tumor nests of Bowen disease compared with the prominent staining of adipophilin in tumor nests with sebaceous differentiation. We show Bowen disease with sebaceous differentiation taking advantage of immunohistochemistry of adipophilin and CK1. Those findings of Bowen disease with sebaceous differentiation may deepen our understandings and insights into the pathogenesis of sebaceous carcinoma and Bowen disease.

https://ift.tt/2PGUfWA

Book Review of “Alopecia” by Mariya Miteva

No abstract available

https://ift.tt/2PhVQp7

Verrucous Plaque With Unusually Large Candida Blastoconidia: A Unique Clinicopathological Presentation of Systemic Mucocutaneous Candidiasis

Abstract: Mucocutaneous candidiasis is a common infection affecting both immunocompetent and immunosuppressed individuals. Diversity in the clinical and histopathological presentation of mucocutaneous candidiasis is well known. However, the occurrence of cutaneous verrucous lesions and giant yeast-like structures has been rarely reported. In this article, we describe a case of disseminated mucocutaneous candidiasis in an immunosuppressed patient who presented as a verrucous plaque on the scrotum with giant Candida blastoconidia. This peculiar presentation expands the clinicopathological spectrum of mucocutaneous candidiasis and highlights the wide range of clinical manifestations and great morphologic variability of this common fungal infection.

https://ift.tt/2PGU3GQ

Exenatide-Induced Panniculitis: Utility of the Acid-Fast Stain to Identify Injected Microspheres

No abstract available

https://ift.tt/2P9XCIv

Primary Cutaneous Follicle Center Lymphoma Clear Cell Variant: Expanding the Spectrum of Cutaneous Clear Cell Neoplasms

Abstract: Primary cutaneous follicle center lymphoma is the most frequent cutaneous B-cell lymphoma despite the fact that is an uncommon disease. Mild biological behavior and good prognosis characterized this neoplasm with a low aggressiveness compared with classic nodal follicular lymphoma (FL). Rare histological variants have been described. We present the case of a 72-year-old man who underwent surgery for a cutaneous nodule on his left scapula. The biopsy showed a dermal clear cell proliferation arranged in a nodular and diffuse pattern. The cells stained positive for CD20 and Bcl-6 supporting B-cell follicular differentiation. The final diagnosis was "primary cutaneous follicle center lymphoma" with "clear cell changes" according to the 2016 World Health Organization classification of lymphoid neoplasms. Additional tests to rule out a systemic involvement were performed. The prognosis was favorable with a disease-free survival of 7 years after complete surgical excision. It has been assumed that cutaneous tumors composed of clear cells may have an epithelial, melanocytic, adnexal, mesenchymal, or metastatic origin. The correct histopathological diagnosis required immunohistochemistry and even molecular techniques. To the best of our knowledge, this is the first report of a cutaneous clear cell lymphoma and of a FL with clear cell features. Our findings provide evidence that the heterogeneity of FL is greater than previously thought and expand the spectrum of differential diagnosis in cutaneous clear cell neoplasms. Dermatopathologists should be aware of this entity and should comprise a PanB marker in their first- or second-line immunohistochemistry for the correct diagnosis of a dermal clear cell proliferation.

https://ift.tt/2PI7kz1

Functional variant of CHI3L1 gene is associated with neck metastasis in oral cancer

Abstract

Objectives

Oral cancer is the most common head and neck malignancy, and it is associated with a high recurrence rate and lymph node metastasis potential. YKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein that serves as a biomarker in several diseases. It also plays a crucial role in regulating many characteristics of cancer, such as cell growth, migration, anti-apoptosis, and angiogenesis. Accumulating evidence supports the link between single-nucleotide polymorphisms (SNPs) and oral cancer, but no report on the association between CHI3L1 polymorphisms and oral cancer is available. Thus, the present study evaluated the contribution of CHI3L1 SNPs to oral cancer susceptibility and clinicopathology.

Materials and methods

This study recruited a total of 2362 subjects, comprising 1190 healthy male controls and 1172 male patients with oral cancer. Allelic discrimination of the CHI3L1 polymorphisms − 1371 G>A (rs6691378), − 247 G>A (rs10399805), − 131 C>G (rs4950928), and + 2950 T>C (rs880633) was assessed through real-time polymerase chain reaction.

Results

We detected a significant association of rs10399805 and rs6691378 with the risk of oral cancer (AOR, 1.537; 95% CI, 1.089–2.168; p = 0.014; AOR, 1.561; 95% CI, 1.131–2.156; p = 0.007, respectively) after adjustment for three potential confounders, smoking, betel nut chewing, and alcohol consumption. Moreover, we found that oral cancer patients carrying the homozygous A/A genotype of the rs10399805 (p = 0.035) or rs6691378 polymorphism (p = 0.023) showed a significantly lower risk of lymph node metastasis. Moreover, according to the Genotype-Tissue Expression database, the rs10399805 and rs6691378 polymorphisms in the promoter region were associated with decreased levels of CHI3L1 mRNA.

Conclusions

In conclusion, we found that the homozygous mutant allele of rs10399805 and rs6691378 appeared to have significantly lower risk of lymph node metastasis and associated with its mRNA levels in oral cancer.

Clinical relevance

The CHI3L1 polymorphisms rs10399805 and rs6691378 may act as biomarkers for predicting lymph node metastasis in oral cancer patients.

https://ift.tt/2NOBvTm

Atezolizumab Plus nab-Paclitaxel in the Treatment of Metastatic Triple-Negative Breast Cancer

This phase 1b multicohort study assessed 33 patients with advanced triple-negative breast cancer treated with atezolizumab plus nab-paclitaxel to examine its safety, tolerability, and preliminary clinical activity.

https://ift.tt/2J5Fieg

Pilot Randomized Trial of a Pharmacy Intervention for Older Adults with Cancer

AbstractBackground.Oncology clinicians often struggle with managing medications and vaccinations in older adults with cancer. We sought to demonstrate the feasibility and preliminary efficacy of integrating pharmacists into the care of older adults with cancer to enhance medication management and vaccination administration.Methods.We randomly assigned patients aged ≥65 years with breast, gastrointestinal, or lung cancer receiving first‐line chemotherapy to the pharmacy intervention or usual care. Patients assigned to the intervention met with a pharmacist once during their second or third chemotherapy infusion. We obtained information about patients' medications and vaccinations via patient report and from the electronic health record (EHR) at baseline and week 4. We determined the number of discrepant (difference between patient report and EHR) and potentially inappropriate (Beers Criteria assessed by nonintervention pharmacists blinded to group assignment) medications. We defined the intervention as feasible if >75% of patients enrolled in the study and received the pharmacist visit.Results.From January 17, 2017, to October 27, 2017, we enrolled and randomized 60 patients (80.1% of patients approached). Among those assigned to the intervention, 96.6% received the pharmacist visit. At week 4, intervention patients had higher rates of acquiring vaccinations for pneumonia (27.6% vs. 0.0%, p = .002) and influenza (27.6% vs. 0.0%, p = .002) compared with usual care. Intervention patients had fewer discrepant (5.82 vs. 8.07, p = .094) and potentially inappropriate (3.46 vs. 4.80, p = .069) medications at week 4, although differences were not significant.Conclusion.Integrating pharmacists into the care of older adults with cancer is feasible with encouraging preliminary efficacy for enhancing medication management and improving vaccination rates.Implications for Practice.Results of this study showed the feasibility, acceptability, and preliminary efficacy of an intervention integrating pharmacists into the care of older adults with cancer. Notably, patients assigned to the intervention had fewer discrepant medications and were more likely to acquire vaccinations for pneumonia and influenza. Importantly, this work represents the first randomized controlled trial involving the integration of pharmacists into the outpatient oncologic care of older adults with cancer. In the future, a larger randomized trial is needed to demonstrate the efficacy of this care model to enhance medication management and improve vaccination outcomes for older patients with cancer.

https://ift.tt/2EzEa3Y

Sight‐threatening Graves’ orbitopathy: twenty years’ experience of a multidisciplinary thyroid‐eye outpatient clinic

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2EAlmS9

TraceIT Tissue Marker to Mark the Primary Resection Bed Margins of Oropharyngeal Cancers

Condition:   Oropharyngeal Cancer
Intervention:   Device: TraceIT Tissue Marker
Sponsor:   Washington University School of Medicine
Not yet recruiting

https://ift.tt/2CrA9fo

Behavior of the Upper Cervical Spine in Rugby Players

Condition:   Cervical Spine Destabilization
Intervention:   Other: Destabilization of the upper cervical spine by Cervistab
Sponsor:   University Hospital, Montpellier
Recruiting

https://ift.tt/2CXtdaO

Nanoliposomal Irinotecan in Head & Neck and Esophagus After Prior Platinum-based Chemotherapy or Chemoradiotherapy

Condition:   Head & Neck Cancer
Intervention:   Drug: nanoliposomal irinotecan
Sponsors:   National Health Research Institutes, Taiwan;   China Medical University Hospital;   Tri-Service General Hospital;   Taipei Veterans General Hospital, Taiwan;   National Cheng-Kung University Hospital
Not yet recruiting

https://ift.tt/2CsErmC

Safety and Efficacy of SCT200 in Head and Neck Squamous Cell Carcinoma

Condition:   Head and Neck Cancer
Intervention:   Drug: Anti-EGFR monoclonal antibody
Sponsors:   Sinocelltech Ltd.;   Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Not yet recruiting

https://ift.tt/2CSmjUh

Prospective Observational Trial to Evaluate Quality of Life After Neoadjuvant or Definitive Chemoradiation in Patients With Esophageal Cancer

Conditions:   Quality of Life;   Chemoradiation;   Esophageal Cancer
Interventions:   Other: EORTC QLQ C30;   Other: EORTC QLQ OES-18;   Other: EORTC OG-25
Sponsor:   Ludwig-Maximilians - University of Munich
Recruiting

https://ift.tt/2CtES03

Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic Therapy

Conditions:   Cancer;   Esophagus Squamous Cell Carcinoma;   Squamous Cell Carcinoma of the Head and Neck;   Anal Canal Squamous Cell Carcinoma;   Metastatic Cancer
Intervention:  
Sponsor:   University Health Network, Toronto
Not yet recruiting

https://ift.tt/2CUnMtg

Scholar : American Journalism, Volume 35, Issue 3, Summer 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content American Journalism, Volume 35, Issue 3, Summer 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Editorial Editor's Note By Ford Risley Pages: 275 | DOI: 10.1080/08821127.2018.1493313 Articles The Accidental Press Critic: Newsroom Ethnography and Resistance to Self-criticism and Management Change at the New York Times in 1974 By Kevin M. Lerner Pages: 276-297 | DOI: 10.1080/08821127.2018.1491203 The Life Cycle and Conventions of Nineteenth-Century Breaking News: Disaster Reporting of the 1875 Virginia City Fire By Katrina J. Quinn Pages: 298-314 | DOI: 10.1080/08821127.2018.1491204 Poor Richard Revised: Benjamin Franklin and the Ritual Economy of Copyright in Colonial America By Jason Lee Guthrie Pages: 315-333 | DOI: 10.1080/08821127.2018.1491205 Reading Helen Jewett's Murder: The Historiographical Problems and Promises of Journalism Michael Buozis Pages: 334-356 | DOI: 10.1080/08821127.2018.1491206 Professional Notes It Ain't Over 'Til It's Over: Ending (?) the Narrative about the Chicago Tribune and the Battle of Midway Patrick S. Washburn & Michael S. Sweeney Pages: 357-369 | DOI: 10.1080/08821127.2018.1491207 Book Reviews Defending the Masses: A Progressive Lawyer's Battles for Free Speech Pages: 370-372 | DOI: 10.1080/08821127.2018.1491218 Book Review Pages: 372-374 | DOI: 10.1080/08821127.2018.1491223 Across the Waves: How the United States and France Shaped the International Age of Radio Pages: 374-376 | DOI: 10.1080/08821127.2018.1491221 Alone atop the Hill: The Autobiography of Alice Dunnigan, Pioneer of the National Black Press Pages: 376-378 | DOI: 10.1080/08821127.2018.1491224 Future Proofing the News: Preserving the First Draft of History Pages: 378-380 | DOI: 10.1080/08821127.2018.1491227 Race News: Black Journalists and the Fight for Racial Justice in the Twentieth Century Pages: 380-382 | DOI: 10.1080/08821127.2018.1491228 The Essay Film after Fact and Fiction Pages: 382-384 | DOI: 10.1080/08821127.2018.1491230 We Believed We Were Immortal: Twelve Reporters Who Covered the 1962 Integration Crisis at Ole Miss Pages: 384-386 | DOI: 10.1080/08821127.2018.1491229 Digital Media Reviews Billy Ireland Cartoon Library & Museum Mary Spillman Reviewed by Pages: 387-389 | DOI: 10.1080/08821127.2018.1491231 Roy W. Howard Archive Pages: 389-391 | DOI: 10.1080/08821127.2018.1491232 The Museum of Broadcast Communications, Chicago, Illinois Len O'Kelly Pages: 391-393 | DOI: 10.1080/08821127.2018.1491233 Endnotes Endnotes Pages: 394-395 | DOI: 10.1080/08821127.2018.1491208 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Journal of Natural History, Volume 52, Issue 33-34, September - September 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Journal of Natural History, Volume 52, Issue 33-34, September - September 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles The ninth brachypterous Onthophagus Latreille (Coleoptera: Scarabaeidae: Scarabaeinae) of the world: a new species from Mexico Héctor Jaime Gasca Álvarez, Mario Zunino & Cuauhtémoc Deloya Pages: 2121-2132 | DOI: 10.1080/00222933.2018.1515382 The occurrence of facultative paedomorphosis in a lacustrine population of the Pyrenean newt (Calotriton asper): morphology and age structure Sebastià Camarasa, Fèlix Amat, Delfí Sanuy & Neus Oromi Pages: 2133-2145 | DOI: 10.1080/00222933.2018.1516831 Neotropical Lispe (Diptera: Muscidae): notes, redescriptions and key to species João M. Fogaça & Claudio J. B. de Carvalho Pages: 2147-2184 | DOI: 10.1080/00222933.2018.1515380 Across-shore distribution of Ocypode quadrata burrows in relation to beach features and human disturbance Frank A. Ocaña, Alberto De Jesús-Navarrete & Héctor A. Hernández-Arana Pages: 2185-2196 | DOI: 10.1080/00222933.2018.1524030 A new species of Friesea (Collembola: Neanuridae) from the Antarctic Continent Penelope Greenslade Pages: 2197-2207 | DOI: 10.1080/00222933.2018.1523483 New records of two decapod crustaceans (Decapoda: Dendrobranchiata and Pleocyemata) from the Gulf of Mannar, India Vinay P. Padate, Mithila S. Bhat & Chandrashekher U. Rivonker Pages: 2209-2220 | DOI: 10.1080/00222933.2018.1524031 Life history of the Rio Grande leopard frog (Lithobates berlandieri) in Texas Daniel F. Hughes & Walter E. Meshaka, Jr Pages: 2221-2242 | DOI: 10.1080/00222933.2018.1526983 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Platelet‐rich plasma: Potential role in combined therapy for vitiligo

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NQkiZB

Vulvar Cancer Association with Groin Hidradenitis Suppurativa: A Large, Urban, Midwestern U.S. Patient Population Study

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Supriya Rastogi, Kevin R. Patel, Vivek Singam, Yasmeen Ali, Jing Gao, Ahmad Amin, Bethanee J. Schlosser, Dennis P. West, Beatrice Nardone

https://ift.tt/2J6rdNQ

Tumor necrosis factor-alpha inhibitors for the treatment of pyoderma gangrenosum not associated with inflammatory bowel diseases: a multicenter retrospective study

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Laurie Rousset, Adèle de Masson, Edouard Begon, Axel Villani, Maxime Battistella, Michel Rybojad, Marie Jachiet, Martine Bagot, Jean-David Bouaziz, Clémence Lepelletier

https://ift.tt/2OzMkhp

Epidemiology of Nickel Sensitivity: Retrospective Cross-Sectional Analysis of North American Contact Dermatitis Group (NACDG) Data 1994-2014

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Erin M. Warshaw, Amy J. Zhang, Joel G. DeKoven, Howard I. Maibach, Donald V. Belsito, Denis Sasseville, Joseph F. Fowler, Anthony F. Fransway, Toby Mathias, Melanie D. Pratt, James G. Marks, Kathryn A. Zug, Matthew J. Zirwas, James S. Taylor, Vincent A. DeLeo

Abstract

Background

Nickel is a common allergen.

Objective

To examine the epidemiology of nickel sensitivity in North America.

Methods

Retrospective, cross-sectional analysis of 44,097 patients patch tested by the North American Contact Dermatitis Group from 1994-2014. Nickel sensitivity was defined as a positive patch test to nickel. We evaluated frequency of nickel sensitivity and patient demographics. For each positive nickel reaction, we tabulated clinical relevance, occupational relatedness, and exposure sources.

Results

Average frequency of nickel sensitivity was 17.5% (1994-2014). Nickel sensitivity significantly increased over time (14.3% 1994-1996 to 20.1% 2013-2014, p<0.0001). Nickel sensitive patients were significantly more likely to be female, young, non-Caucasian, atopic (eczema and asthma), and/or have dermatitis affecting the face, scalp, ears, neck, arm, or trunk (p values ≤0.0474). Overall, 55.5% of reactions were currently clinically relevant; this frequency significantly increased over time (44.1% 1994-1996 to 51.6% 2013-2014, p<0.0001). Occupational relatedness was 3.7% overall with a significant decrease over time (7.9% 1994-1996 to 1.9% 2013-2014, p<0.0001). Jewelry was the most common source.

Limitations

Tertiary referral population.

Conclusions

Nickel allergy is of significant public health importance in North America. The frequency of nickel sensitivity in patients referred for patch testing has significantly increased over a 20-year period.

https://ift.tt/2J8hK8z

Hydrocolloid Dressing Application for the Treatment of Pediatric Onychodystrophies

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Solomon Geizhals, Christine T. Lauren, Shari R. Lipner

https://ift.tt/2OyqP0n

Antioxidant supplements in combination with phototherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Han Mi Jung, Yu Seok Jung, Ji Hae Lee, Gyong Moon Kim, Jung Min Bae

https://ift.tt/2J8hCWD

Credit-card sized field and benchtop NMR relaxometers using field programmable gate arrays

Publication date: Available online 18 October 2018

Source: Magnetic Resonance Imaging

Author(s): J. Beau W. Webber, Pavel Demin

Abstract

The tools for developing systems for NMR improve each year. Some firmware based designs based on Field Programmable Gate Arrays (FPGAs) have been developed to implement both the core and peripheral apparatus for NMR Relaxometers and NMR Cryoporometers. Hand held in size they are particularly suitable for desktop, mobile and field use.

Software tools now enable the writing of firmware that enable the rapid design of digital and digitised R.F. data and control systems. This firmware can then be loaded into and run on hardware that often is only the size of a credit-card. These devices can include a single-chip Linux computer with an FPGA capable of processing digital RF on the same chip. These can generate RF signals digitally, process RF signals for up- and down-conversion, and can provide an on chip NMR pulse sequencer.

An extremely well tested NMR digital transmitter has been upgraded to use the latest surface-mount Bipolar and Field Effect Transistors. The circuitry is now the size of a book of matches, and interfaces to credit-card sized FPGA modules for RF generation, phase shifting and drive signals. This NMR transmitter design uses digital logic principles rather than conventional tuned R.F. techniques Offering both active-damping and active-quench, a very square R.F. Pulse with fast turn off is achieved, with Mark 1 giving 2.6 μs π/2 and 4.8 μs π pulses into a 5 mm diameter NMR sample (2.7 mT B₁) at 20 MHz for Protons. T1ρ pulses are stable and consistent.

https://ift.tt/2JbXHq1

Effect of Physical and Chemical Hair Removal Methods on Skin Barrier Function in vitro: Consequences for a Hydrophilic Model Permeant

Background: Although very common in our society, the effect of hair removal on physiological skin parameters and on the ingress of applied chemicals has not been systematically investigated. Thus, as a first step, the aim of the present study was to elucidate the effect of hair removal through epilation (electric epilation, waxing) and depilation (dry and wet shaving, depilatory cream) on skin properties in vitro using the porcine ear model. Methods: Attenuated total reflection Fourier transform infrared spectroscopy, measurement of the transepidermal water loss (TEWL), visualization by capacitance-based contact imaging, confocal Raman spectroscopy (CRS), diffusion cell studies and tape stripping experiments were employed. Results: Increased TEWL and altered skin permittivity maps were observed. Decreased stratum corneum thickness was observed after waxing. Diffusion cell studies showed increased skin permeation especially in case of dry shaving, electric epilation and waxing. Conclusion: Considering CRS and diffusion cell data, a moderate if significant decrease in skin barrier function was found after hair removal by dry shaving (physical skin/material interaction) and epilation methods (plucking out the entire hair, for example, by electrical epilation and waxing). Subsequent experiments will include testing of different permeants covering a broad range of physicochemical properties in vitro and confirming our findings in vivo.
Skin Pharmacol Physiol 2019;32:8–21

https://ift.tt/2q17OoP

Lung cancer with bone metastases in the United States: an analysis from the Surveillance, Epidemiologic, and End Results database

Abstract

The present study used the Surveillance, Epidemiology and End Results (SEER) database to identify demographic and prognostic characteristics of lung cancer with bone metastases in the United States from 2010 to 2014. 30,364 patients with metastatic lung cancer to bones were identified in the SEER database. Their information on the basic characteristics and the histological signatures of the cancer was extracted and analyzed. Joinpoint analysis was used to test the trends in annual percentage change (APC) of the incidence. 1-year survival rate among patients with metastatic lung cancer to bones was only 20.2%, and median survival time was about 3.0 months for those patients. Young age, female sex, race other than white and black, tumor in lobes, smaller tumor, adenocarcinoma, and surgery for primary site were associated with a significant survival benefit. APC of the incidence almost increased steadily on the whole and reached the level of statistical significance among the patients older than age 60. Although there are some signatures associated with better prognosis, the overall outcome remains very poor in patients with metastatic lung cancer to bones. In addition, the incidence of lung cancer with bone metastases is increasing in certain subgroups in the United States.

https://ift.tt/2CSuD6h