Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wpYOgk
Τρίτη 28 Αυγούστου 2018
Review of the medical literature and assessment of current utilization patterns regarding the use two common fluorescence in situ hybridization assays in the diagnosis of dermatofibrosarcoma protuberans and clear cell sarcoma
Immunohistochemical expression of melanocytic and myofibroblastic markers and their molecular correlation in atypical fibroxanthomas and pleomorphic dermal sarcomas MiTF and calponin expression in AFX and PDS
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2C4i8F4
Isolated Fourth Nerve Palsy in Nontraumatic Tentorial Hemorrhage
Abstract: A 46-year-old woman being treated with warfarin for antiphospholipid antibody syndrome experienced a rise in international normalized ratio (INR) to 5.4 and developed sudden headache and diplopia. Neuro-ophthalmologic examination disclosed a right fourth nerve palsy. Noncontrast computed tomography revealed a subdural hematoma layered along the right tentorium cerebelli, directly in the path of the nerve. With normalization of the INR, the palsy markedly improved over subsequent weeks. This is a unique case of a nontraumatic subdural hematoma causing a fourth nerve palsy. Address correspondence to Jonathan D. Trobe, MD, University of Michigan, Ann Arbor, MI 48105; E-mail: jdtrobe@umich.edu The authors report no conflicts of interest. © 2018 by North American Neuro-Ophthalmology Society
https://ift.tt/2NyP4H2
https://ift.tt/2NyP4H2
Visual Field Mean Deviation at Diagnosis of Idiopathic Intracranial Hypertension Predicts Visual Outcome
Background: A robust predictor of visual outcome in idiopathic intracranial hypertension (IIH) would be useful in management, but there is limited information on this point. The purpose of this study was to ascertain whether visual field mean deviation on standard static perimetry performed at diagnosis in a large patient cohort is a reliable predictor of visual outcome. Methods: We retrospectively reviewed the automated visual field mean deviations at diagnosis and at final encounter in 79 patients with IIH examined in the neuro-ophthalmology clinics at a single academic medical center from 1999 to 2015. Results: Of the 79 study patients, 66 (84%) entered with visual field mean deviations of −7 dB or better. Of those 66 patients, 59 (89%) had final mean deviations of −4 dB or better and 33 (56%) had final mean deviations of −2 dB or better. The single patient who had an initial mean deviation of −7 dB or better and a poor final mean deviation (−32 dB) was nonadherent to prescribed medication. Of the 13 (21%) patients who entered with mean deviations worse than −7 dB, 11 (85%) ended up with poor visual outcomes, their final mean deviations ranging from −5 dB to −32 dB. Over half of those 13 patients had required surgery for IIH, often within 3 weeks of diagnosis, owing to severe papilledema and visual dysfunction at the time of diagnosis. Conclusions: Based on this retrospective study, patients with IIH who have relatively mild visual dysfunction at diagnosis are likely to have a favorable visual outcome, provided they are adherent to recommended treatment. Many of those with poor visual function at diagnosis will have unfavorable visual outcomes despite aggressive treatment. Address correspondence to Jonathan D. Trobe, MD, 1000 Wall Street, Ann Arbor, MI 48105; E-mail: jdtrobe@umich.edu The authors report no conflicts of interest. © 2018 by North American Neuro-Ophthalmology Society
https://ift.tt/2okfQIs
https://ift.tt/2okfQIs
Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus–pituitary–adrenal axis in vitro
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2LC3yUO
Laser therapy for ocular lesions of naevus of Ota
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2MWaBws
Associated factors of widespread pattern of dermatitis among patch test population: 12‐Year retrospective study
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2NtbWrs
Severe cutaneous eruptions following the topical use of preparations containing bufexamac: Is it time to reconsider its registration in Australia?
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2ojeX2I
Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study
British Journal of Dermatology, EarlyView.
https://ift.tt/2NqIvGF
A 10‐year longitudinal follow‐up study of a U.K. paediatric transplant population to assess for skin cancer
British Journal of Dermatology, EarlyView.
https://ift.tt/2MYha1G
Dermatology on the General Practice Bookshelf
British Journal of Dermatology, EarlyView.
https://ift.tt/2NtYCmQ
Predictors of Hand Dexterity after Single-Digit Replantation
J reconstr Microsurg
DOI: 10.1055/s-0038-1669446
Background Microsurgical replantation of the thumb and digits has become an increasingly familiar technique in clinical practice worldwide. However, successful digit replantation does not always provide better hand function than revision amputation. Little information is available regarding predictors of motor skill activities of replanted hands. Therefore, we retrospectively evaluated hand dexterity after single-digit replantation at a minimum follow-up of 1 year and analyzed the factors influencing dexterity. Methods This retrospective cohort study included 23 patients treated for amputation injuries at our institution from 2014 to 2015. Patients with amputations from Tamai's zone 2 to 5 of the thumb (3 patients), index finger (11 patients), or middle finger (9 patients) who underwent digital replantation surgery and were followed up for more than 1 year were included. Follow-up evaluations were conducted at an average of 23 months postoperatively (range: 13–25 months). We hypothesized that possible factors influencing hand dexterity after single-digit replantation were patient age, injured finger, key pinch strength, Semmes–Weinstein test result, and percentage of total active motion. Relationships between the outcome variable, which was the result of the Purdue Pegboard Test of hand dexterity, and explanatory variables were analyzed using Spearman's correlation coefficient. A p-value of < 0.05 indicated statistical significance. Results No postoperative complications occurred. Univariate analysis indicated that decreased hand dexterity after single-digit replantation was significantly associated with older age (p = 0.001) and poor recovery of sensation, as shown by the Semmes–Weinstein test (p = 0.012). Conclusion Patient age was a risk factor for low hand dexterity after replantation surgery. Recovery of finger sensitivity enhanced dexterity of motor skill activities following finger replantation surgery.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2ogMniz
Scholar : These new articles for International Journal of Rail Transportation are available online
|
Scholar : These new articles for Danish Journal of Archaeology are available online
|
The Use of Pulse Oximetry to Diagnose Limb Ischaemia
The accurate diagnosis of limb ischaemia in the acute trauma setting is time critical. In cases of polytrauma and complex limb injuries this assessment can be difficult and is often first performed by a junior member of the team. The assessment of neurovascular status of these injuries is much the same as it was decades ago. Recently clinical methods thought to be of use are being proven otherwise. In our trauma centre we now routinely use pulse oximetry in the assessment of limb and digit ischaemia.
https://ift.tt/2wlraIM
Trends for facial injectable therapies in medical aesthetics
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):45-46
https://ift.tt/2LBlMWz
Multiple miliary osteoma cutis of face
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):95-97
Multiple miliary osteoma cutis is an uncommon condition presenting as multiple skin-colored papules of variable sizes on the face. A 48-year-old woman presented with multiple skin-colored hard papules on both cheeks. Examination revealed firm-to-hard dome-shaped asymptomatic papules in cluster over both cheeks. A punch biopsy was performed, which showed evidence of focal bony trabeculae with associated normal appendages. Few larger papules were incised and followed up with curettage of bony material and closed. All lesions could not be incised and removed because of large number of lesions in cluster.
https://ift.tt/2wofk0B
Dynamic relaxers of the face
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):47-50
Dynamics of the facial aesthetics is changing rapidly as we treat more and more faces. Our understanding of the molecule at hand and its various applications only expands as our learnings progress. Perception and expectation of the end goal to beauty itself are evolving, and therefore newer ways of analyzing, understanding, and delivering of any aesthetic drug have to evolve continuously. Botulinum toxin is one of the wonders in the aesthetic world, which led the entire focus of the medical fraternity into nonsurgical facial aesthetics. Botulinum toxin was and is still the best tool for relaxing lateral canthal lines and glabellar frown lines. However, it has evolved further to now impart changes/enhancements in skin texture and luminosity, enhancement in facial shape, and reduction in glandular activity of sebaceous, sweat, and salivary glands, therefore leading to a lot more aesthetic application while it still remains as the line eraser.
https://ift.tt/2PaPbJt
Innovative use of abdominoplasty specimen
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):88-90
Simulator training is important for understanding nipple–areolar complex reconstruction. Human tissue is the best tissue simulator for surgical training. Abdominoplasty specimen is a useful tissue simulator, which is suitable for practicing nipple–areolar complex reconstruction. It is similar to the natural mound created in breast reconstruction. Authors have shared their experience of using abdominoplasty specimen for simulator training of nipple–areolar complex reconstruction for plastic surgery residents. Abdominoplasty specimen is cost-effective, readily available, and an efficient tool for plastic surgery training for the residents.
https://ift.tt/2MzhCUt
Simplifying injectables for volumetric rejuvenation of face
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):51-59
Volumetric rejuvenation with fillers is a minimally invasive technique used for facial volume restoration. Volume restoration demands adequate knowledge of fat pads and vascularity of the face and the understanding of the depletion patterns. Volumetric restoration with injectable has witnessed a paradigm shift in the last decade with a global rejuvenation, acquiring a predominant emphasis over focal wrinkle filling to restore the depletion pattern of facial fat layers. The techniques used to achieve optimal restoration of facial volume revolve around zonal lifting and tenting, and the impact of treatment on one zone of the surrounding zones is crucial. A face mapping performed for filler technique has thus evolved, with many experts advocating varied techniques from global restoration to point lifts at key areas, to improve the outcome of filler injections, albeit safely, thus simplifying the process. A systematic approach to various techniques and the point lifts in various zones pertaining to the face structure in the Indian skin are highlighted in this article.
https://ift.tt/2LBlxuD
Dermatological surgery in patients with cardiac implantable electronic devices: A new paradigm
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):100-101
https://ift.tt/2wmJAJ7
Beware what you inject: Complications of injectables—dermal fillers
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):60-66
Cosmetic filler injections are most popular among the antiaging procedures. As in any other cosmetic injectable procedures, complications are likely to occur even under experienced hands. However, it is the duty of the aesthetic physician to identify and manage these potential complications. The objective of this symposia is to help the aesthetic physician to identify these complications early and manage them appropriately to improve outcomes.
https://ift.tt/2PctM2I
An innovative training model for practicing hairline designing
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):83-87
Hair transplantation has undergone a massive transformation in todays world. Besides advancement in technique there has also been a great increase in the demand for hair transplant. This rise in demand for hair transplant has further led to an increase in the requirement of professionally trained hair transplant surgeons. In this article we have described a new, versatile and simple technique for hair transplant surgeons to effectively practice hair line designing. This innovative technique proves vital in perfecting the art of the recipient area designing for the hairline, eyebrow, beard etc. for a surgeon who is undergoing training as well as for previously trained surgeons to rehearse an old skill to gain further confidence. Besides helping us practice the art of hairline designing this technique also teaches us the correct angle, direction, depth and density of slits which are ideal and thus helps us to be better prepared for the real life scenario.
https://ift.tt/2MEpvbc
Fat busters: Lipolysis for face and neck
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):67-72
Persistence and hypertrophy of fat pads particularly of the face and neck region disturb beauty proportions, thus demand treatments. Phosphatidylcholine and deoxycholic acid are the most commonly used solutions for injection lipolysis. As we stand today, sodium deoxycholate preparation is approved by the US Food and Drug Administration for the same. This article describes the correct use of solution to achieve fat reduction and ensure safety. Complete details of patient selection, assessment, dosing, and injection techniques are described in this article. A brief note on posttreatment care and complications is also provided.
https://ift.tt/2PfCsVN
Lipoid proteinosis: Skin resurfacing with combination of fractional CO2 and non-ablative radio frequency: A rare case report
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):91-94
Lipoid proteinosis (LP) is a rare autosomal-recessive genodermatosis, characterized by the deposition of amorphous hyaline-like material in different parts of the body, especially the skin and mucous membranes. Disfiguring lesions predominantly affect the facial appearance. No curative therapy and treatment options limited to symptomatic approaches are available. Facial disfigurement in this disease may have a huge negative effect on the patients' psychology and quality of life. With this regard, the patients may benefit very much from the treatments that enhance their cosmetic outlook. We present a 19-year-old female patient with LP who came to us seeking treatment for her facial lesions. She was treated with a combination regimen of fractional carbon dioxide and non-ablative radio frequency with good clinical and aesthetic outcome.
https://ift.tt/2wprJkJ
Arm contouring after massive weight loss: Liposuction-assisted brachioplasty versus standard technique
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):73-78
Massive weight loss (MWL) brachioplasty is frequently requested for the improvement of the appearance and function of arms. Despite its diffusion, this procedure can be associated with significant complications. Liposuction-assisted brachioplasty (LAB) preserves the vascular, nervous, and lymphatic network and reduces the incidence of postoperative complications. This retrospective cohort study is aimed at analyzing two different modalities of arm contouring after MWL by evaluating the outcomes and complications. Of 31 patients (all females, average age 43.5 years), 20 were managed with standard brachioplasty represented by a swallowtail scar and monobloc resection and 11 with brachioplasty combined with aggressive liposuction. Evaluated parameters included age, body mass index, method of weight loss, and complications rate. No statistical analysis was used. Major postoperative complications (reoperation, bleeding, or thromboembolism) were not reported in both groups. The incidence of minor complications (wound separation, wound infection, and seroma) was globally 42%; the incidence of complications was significantly lower in the LAB group (9% vs. 60%). The incidence of hypertrophic scarring or keloid was higher in the control group (55% vs. 18%). Most patients were satisfied after surgery: in the LAB group, 81.8% of the patients expressed a high degree of satisfaction and 18.2% a good degree of satisfaction after 4 months of follow-up. In our experience, the LAB should be preferred in MWL patients because it has a lower rate of complications and a faster recovery than the standard technique. Proper execution requires considerable technical skill and experience.
https://ift.tt/2LBl7Ez
A simple, efficient, and economical head drape technique for facial procedures: The nun’s veil drape
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):98-99
https://ift.tt/2MCKwDq
Anatomy and applications of the #15 scalpel blade and its variations
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):79-82
Scalpels have been used to make skin incisions since the advent of "modern" dermatosurgery. #15 Scalpel blade and #3 handle (Bard-Parker handle) are most frequently used by a dermatosurgeon. Besides the proper equipment, appropriate technique is mandatory to ensure a "precise" incision. In this article, we discuss about the anatomy, variations, and different uses of the #15 scalpel blade and the ideal method of making a "precise" skin incision.
https://ift.tt/2PfCmNV
29th National Dermatology Congress of the Algerian Society of Dermatology Algiers, October 18 and 19, 2017
Journal of Cutaneous and Aesthetic Surgery 2018 11(2):102-103
https://ift.tt/2wknvuQ
Large-Scale Organization of the Hand Action Observation Network in Individuals Born Without Hands
Abstract
The human high-level visual cortex comprises regions specialized for the processing of distinct types of stimuli, such as objects, animals, and human actions. How does this specialization emerge? Here, we investigated the role of effector-specific visuomotor coupling experience in shaping the organization of the action observation network (AON) as a window on this question. Observed body movements are frequently coupled with corresponding motor codes, e.g., during monitoring one's own movements and imitation, resulting in bidirectionally connected circuits between areas involved in body movements observation (e.g., of the hand) and the motor codes involved in their execution. If the organization of the AON is shaped by this effector-specific visuomotor coupling, then, it should not form for body movements that do not belong to individuals' motor repertoire. To test this prediction, we used fMRI to investigate the spatial arrangement and functional properties of the hand and foot action observation circuits in individuals born without upper limbs. Multivoxel pattern decoding, pattern similarity, and univariate analyses revealed an intact hand AON in the individuals born without upper limbs. This suggests that the organization of the AON does not require effector-specific visuomotor coupling.https://ift.tt/2NqENNh
Brain Activity Tracks Population Information Sharing by Capturing Consensus Judgments of Value
Abstract
Information that is shared widely can profoundly shape society. Evidence from neuroimaging suggests that activity in the ventromedial prefrontal cortex (vmPFC), a core region of the brain's valuation system tracks with this sharing. However, the mechanisms linking vmPFC responses in individuals to population behavior are still unclear. We used a multilevel brain-as-predictor approach to address this gap, finding that individual differences in how closely vmPFC activity corresponded with population news article sharing related to how closely its activity tracked with social consensus about article value. Moreover, how closely vmPFC activity corresponded with population behavior was linked to daily life news experience: frequent news readers tended to show high vmPFC across all articles, whereas infrequent readers showed high vmPFC only to articles that were more broadly valued and heavily shared. Using functional connectivity analyses, we found that superior tracking of consensus value was related to decreased connectivity of vmPFC with a dorsolateral PFC region associated with controlled processing. Taken together, our results demonstrate variability in the brain's capacity to track crowd wisdom about information value, and suggest (lower levels of) stimulus experience and vmPFC–dlPFC connectivity as psychological and neural sources of this variability.https://ift.tt/2MSKGWB
Mechanisms of Spontaneous Electrical Activity in the Developing Cerebral Cortex—Mouse Subplate Zone
Abstract
Subplate (SP) neurons exhibit spontaneous plateau depolarizations mediated by connexin hemichannels. Postnatal (P1–P6) mice show identical voltage pattern and drug-sensitivity as observed in slices from human fetal cortex; indicating that the mouse is a useful model for studying the cellular physiology of the developing neocortex. In mouse SP neurons, spontaneous plateau depolarizations were insensitive to blockers of: synaptic transmission (glutamatergic, GABAergic, or glycinergic), pannexins (probenecid), or calcium channels (mibefradil, verapamil, diltiazem); while highly sensitive to blockers of gap junctions (octanol), hemichannels (La3+, lindane, Gd3+), or glial metabolism (DLFC). Application of La3+ (100 μM) does not exert its effect on electrical activity by blocking calcium channels. Intracellular application of Gd3+ determined that Gd3+-sensitive pores (putative connexin hemichannels) reside on the membrane of SP neurons. Immunostaining of cortical sections (P1–P6) detected connexins 26, and 45 in neurons, but not connexins 32 and 36. Vimentin-positive glial cells were detected in the SP zone suggesting a potential physiological interaction between SP neurons and radial glia. SP spontaneous activity was reduced by blocking glial metabolism with DFLC or by blocking purinergic receptors by PPADS. Connexin hemichannels and ATP release from vimentin-positive glial cells may underlie spontaneous plateau depolarizations in the developing mammalian cortex.https://ift.tt/2MSKiY9
Domain-Specific Diaschisis: Lesions to Parietal Action Areas Modulate Neural Responses to Tools in the Ventral Stream
Abstract
Neural responses to small manipulable objects ("tools") in high-level visual areas in ventral temporal cortex (VTC) provide an opportunity to test how anatomically remote regions modulate ventral stream processing in a domain-specific manner. Prior patient studies indicate that grasp-relevant information can be computed about objects by dorsal stream structures independently of processing in VTC. Prior functional neuroimaging studies indicate privileged functional connectivity between regions of VTC exhibiting tool preferences and regions of parietal cortex supporting object-directed action. Here we test whether lesions to parietal cortex modulate tool preferences within ventral and lateral temporal cortex. We found that lesions to the left anterior intraparietal sulcus, a region that supports hand-shaping during object grasping and manipulation, modulate tool preferences in left VTC and in the left posterior middle temporal gyrus. Control analyses demonstrated that neural responses to "place" stimuli in left VTC were unaffected by lesions to parietal cortex, indicating domain-specific consequences for ventral stream neural responses in the setting of parietal lesions. These findings provide causal evidence that neural specificity for "tools" in ventral and lateral temporal lobe areas may arise, in part, from online inputs to VTC from parietal areas that receive inputs via the dorsal visual pathway.https://ift.tt/2No927p
Learning to Read Increases the Informativeness of Distributed Ventral Temporal Responses
Abstract
Becoming a proficient reader requires substantial learning over many years. However, it is unknown how learning to read affects development of distributed visual representations across human ventral temporal cortex (VTC). Using fMRI and a data-driven, computational approach, we quantified the development of distributed VTC responses to characters (pseudowords and numbers) versus other domains in children, preteens, and adults. Results reveal anatomical- and hemisphere-specific development. With development, distributed responses to words and characters became more distinctive and informative in lateral but not medial VTC, and in the left but not right hemisphere. While the development of voxels with both positive and negative preference to words affected distributed information, only development of voxels with positive preference to words (i.e., word-selective) was correlated with reading ability. These data show that developmental increases in informativeness of distributed left lateral VTC responses are related to proficient reading and have important implications for both developmental theories and for elucidating neural mechanisms of reading disabilities.https://ift.tt/2LxSMzd
Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor?
Abstract
Previous in vivo studies revealed robust age-related variations in structural properties of the human cerebral cortex during adolescence. Neurobiology underlying these maturational phenomena is largely unknown. Here we employ a virtual-histology approach to gain insights into processes associated with inter-regional variations in cortical microstructure and its maturation, as indexed by magnetization transfer ratio (MTR). Inter-regional variations in MTR correlate with inter-regional variations in expression of genes specific to pyramidal cells (CA1) and ependymal cells; enrichment analyses indicate involvement of these genes in dendritic growth. On the other hand, inter-regional variations in the change of MTR during adolescence correlate with inter-regional profiles of oligodendrocyte-specific gene expression. Complemented by a quantitative hypothetical model of the contribution of surfaces associated with dendritic arbor (1631 m2) and myelin (48 m2), these findings suggest that MTR signals are driven mainly by macromolecules associated with dendritic arbor while maturational changes in the MTR signal are associated with myelination.https://ift.tt/2MDqxEr
A Study of Guselkumab in Participants With Familial Adenomatous Polyposis
Condition: Adenomatous Polyposis Coli
Interventions: Drug: Guselkumab; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Not yet recruiting
https://ift.tt/2MDY9C8
Interventions: Drug: Guselkumab; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Not yet recruiting
https://ift.tt/2MDY9C8
Ketamine-ketorolac Versus Fentanyl- Ketorolac I.M in Children During Bone Marrow Biopsy
Condition: Hematological Malignancy (Leukemia- Lymphoma)
Interventions: Drug: ketamine-ketorolac; Drug: fentanyl- ketorolac
Sponsor: Mansoura University
Not yet recruiting
https://ift.tt/2LzxKjI
Interventions: Drug: ketamine-ketorolac; Drug: fentanyl- ketorolac
Sponsor: Mansoura University
Not yet recruiting
https://ift.tt/2LzxKjI
Low-Dose Weekly vs High-Dose Cisplatin
Condition: Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions: Drug: High-Dose Cisplatin; Drug: Low-Dose Cisplatin; Radiation: Radiotherapy
Sponsor: Lawson Health Research Institute
Not yet recruiting
https://ift.tt/2PL06e4
Interventions: Drug: High-Dose Cisplatin; Drug: Low-Dose Cisplatin; Radiation: Radiotherapy
Sponsor: Lawson Health Research Institute
Not yet recruiting
https://ift.tt/2PL06e4
Endostatin Combined With Chemotherapy for Adjuvant Treatment of Esophageal Cancer
Condition: Esophageal Cancer
Interventions: Drug: Docetaxel; Drug: Nedaplatin; Drug: Endostar
Sponsor: First Affiliated Hospital of Guangxi Medical University
Not yet recruiting
https://ift.tt/2Lzx7GS
Interventions: Drug: Docetaxel; Drug: Nedaplatin; Drug: Endostar
Sponsor: First Affiliated Hospital of Guangxi Medical University
Not yet recruiting
https://ift.tt/2Lzx7GS
Evaluation of early acute radiation-induced brain injury: Hybrid multifunctional MRI-based study
Publication date: Available online 27 August 2018
Source: Magnetic Resonance Imaging
Author(s): Jun Yang, Zeyan Xu, Jingyan Gao, Chengde Liao, Pengfei Wang, Yifan Liu, Tengfei Ke, Qinqing Li, Dan Han
Abstract
Purpose
Radiation injury is a serious threat to humans that requires prompt and accurate diagnosis and assessment. Currently, there is no effective imaging method to evaluate acute radiation injury in the early stage. We used hybrid multifunctional MRI to evaluate acute radiation-induced brain injury.
Materials and methods
Different extents of brain injury were created by exposing SD rats to different radiation doses, namely, 0, 10, 20, 30 and 40 Gy. DCE, IVIM-MRI and MRS were performed on the 5th day after irradiation. Immunohistochemistry, western blotting and electron microscopy were used to determine histopathological changes in neurons and glial cells.
Results
The Ktrans, Ve, and iAUC values in DCE and the S0, f and D* values in IVIM showed significant positive correlations with injury grade. In particular, Ktrans, iAUC and S0 showed very good correlations with injury grade (r > 0.5, P < 0.05), and the values in the 30 Gy group were significantly higher than those in the other groups (P < 0.05). The NAA/Cr ratio in the 30 Gy group was significantly lower than those in the other groups, whereas the NAA/Cho ratio increased from the 10 Gy to the 20 Gy group and decreased significantly in the 30 Gy group (P < 0.05). VEGF, Caspase-3 and GFAP increased with irradiation dose increasing from 10 Gy to 30 Gy (P < 0.05). ROC analysis demonstrated that multifunctional MRI was more effective for diagnosing the 30 Gy group than it was for the 10 Gy and 20 Gy groups.
Conclusion
Hybrid multifunctional MRI can noninvasively evaluate acute radiation-induced brain injury in the early stage, particularly high-dose radiation exposure.
https://ift.tt/2wjX8VO
Along-tract analysis of the arcuate fasciculus using the Laplacian operator to evaluate different tractography methods
Publication date: Available online 27 August 2018
Source: Magnetic Resonance Imaging
Author(s): Lia Talozzi, Claudia Testa, Stefania Evangelisti, Lorenzo Cirignotta, Claudio Bianchini, Stefano Ratti, Paola Fantazzini, Caterina Tonon, David Neil Manners, Raffaele Lodi
Abstract
Purpose
We propose a new along-tract algorithm to compare different tractography algorithms in tract curvature mapping and along-tract analysis of the arcuate fasciculus (AF). In particular, we quantified along-tract diffusion parameters and AF spatial distribution evaluating hemispheric asymmetries in a group of healthy subjects.
Methods
The AF was bilaterally reconstructed in a group of 29 healthy subjects using the probabilistic ball-and-sticks model, and both deterministic and probabilistic constrained spherical deconvolution. We chose cortical ROIs as tractography targets and the developed along-tract algorithm used the Laplacian operator to parameterize the volume of the tract, allowing along-tract analysis and tract curvature mapping independent of the tractography algorithm used.
Results
The Laplacian parameterization successfully described the tract geometry underlying hemispheric asymmetries in the AF curvature. Using the probabilistic tractography methods, we found more tracts branching towards cortical terminations in the left hemisphere. This influenced the left AF curvature and its diffusion parameters, which were significantly different with respect to the right. In particular, we detected projections towards the middle temporal and inferior frontal gyri bilaterally, and towards the superior temporal and precentral gyri in the left hemisphere, with a significantly increased volume and connectivity.
Conclusions
The approach we propose is useful to evaluate brain asymmetries, assessing the volume, the diffusion properties and the quantitative spatial localization of the AF.
https://ift.tt/2PflYNv
Scholar : Archives of Agronomy and Soil Science, Volume 64, Issue 12, October 2018 is now available online on Taylor & Francis Online
|
How to get by with half a loop – An investigation of visual and auditory codes in a case of impaired phonological short-term memory (pSTM)
Publication date: Available online 27 August 2018
Source: Cortex
Author(s): Jeremy J. Tree, David Playfoot
Abstract
In the field of cognitive neuropsychology of phonological short-term memory (pSTM), a key debate surrounds the issue of how impairment on tasks deemed to tap this system imply a dissociable phonological input and output buffer system, with the implication that impairments can be fractionated across disruption to separate functional components (Nickels, Howard, & Best, 1997). This study presents CT, a conduction aphasic who showed no impairment on basic auditory discrimination tasks, but had very poor nonword repetition. Clear-cut examples of such cases are very rare (see Jacquemot, Dupoux & Bachoud-Levi, 2007), and we interpret the case with reference to a pSTM model that includes input and output buffers. The dissociation between performance on auditory phonological tasks and visual phonological tasks we interpret as consistent with disruption to the link from input buffer to output buffer without concurrent damage to connections from output to input. Previous research has also shown that patients with impairments of pSTM can make visual confusions with orthographically presented items in tasks seeking to tap this mechanism (Warrington & Shallice, 1972), which might stem from having an incomplete pSTM loop. In light of this we examined whether CT's ability on tests of ISR was affected by visual orthographic similarity among list items, and this is indeed what we observed. On balance then, CT's overall profile is considered best interpreted with respect to a dual buffer pSTM model (e.g., Vallar & Papagno, 2002).
https://ift.tt/2C3dJCG
Action-related dynamic changes in inferior frontal cortex effective connectivity: a TMS/EEG coregistration study
Publication date: Available online 27 August 2018
Source: Cortex
Author(s): Marco Zanon, Sara Borgomaneri, Alessio Avenanti
Abstract
Humans show exquisite abilities to perform versatile finger movements. The inferior frontal cortex (IFC) plays a pivotal role in the visual control of such movements through connections with other sensorimotor regions. Yet, the dynamics of IFC effective connectivity during action execution are still poorly understood. Using single-pulse TMS and simultaneous EEG recording (i.e., TMS-EEG coregistration), we stimulated the left posterior IFC at rest and during a visuomotor task. We recorded TMS-evoked potentials (TEPs) to assess action-related changes in IFC connectivity and localized their sources using sLORETA. We found two key time windows at ∼60 and ∼80 ms after IFC stimulation in which TEPs were modulated by task conditions in remote electrodes. In the first time window (∼60 ms), action-related changes in TEP amplitudes were observed over frontal and temporo-parietal electrodes, reflecting increased IFC connectivity with fronto-parietal motor areas and decreased IFC connectivity with visual occipito-temporal areas. In the second time window (∼80 ms), action-related TEP increases were observed in frontal, temporal and parietal regions partially overlapping with the default-mode network. No similar effects were observed when TMS was administered over a non-motor control area (the left posterior superior temporal sulcus, STS). These findings highlight dynamic changes in IFC connectivity with motor, sensory and default-mode networks. They suggest sequential stages of task-related changes in IFC connectivity possibly related to controlling and sensing actions and inhibiting default-mode brain activity during motor performance.
https://ift.tt/2ofZTTr
Distinct sensitivities of the lateral prefrontal cortex and extrastriate body area to contingency between executed and observed actions
Publication date: Available online 27 August 2018
Source: Cortex
Author(s): Akihiro T. Sasaki, Yuko Okamoto, Takanori Kochiyama, Ryo Kitada, Norihiro Sadato
Abstract
Detecting relationships between our own actions and the subsequent actions of others is critical for our social behavior. Self-actions differ from those of others in terms of action kinematics, body identity, and feedback timing. Thus, the detection of social contingency between self-actions and those of others requires comparison and integration of these three dimensions. Neuroimaging studies have highlighted the role of the frontotemporal network in action representation, but the role of each node and their relationships are still controversial. Here, we conducted a functional MRI experiment to test the hypothesis that the lateral prefrontal cortex and lateral occipito-temporal cortex are critical for the integration processes for social contingency. Twenty-four adults performed right finger gestures and then observed them as feedback. We manipulated three parameters of visual feedback: action kinematics (same or different gestures), body identity (self or other), and feedback timing (simultaneous or delayed). Three-way interactions of these factors were observed in the left inferior and middle frontal gyrus (IFG/MFG). These areas were active when self-actions were directly fed back in real-time (i.e., the condition causing a sense of agency), and when participants observed gestures performed by others after a short delay (i.e., the condition causing social contingency). In contrast, the left extrastriate body area (EBA) was sensitive to the concordance of action kinematics regardless of body identity or feedback timing. Body identity × feedback timing interactions were observed in regions including the superior parietal lobule (SPL). An effective connectivity analysis supported the model wherein experimental parameters modulated connections from the occipital cortex to the IFG/MFG via the EBA and SPL. These results suggest that both social contingency and the sense of agency are achieved by hierarchical processing that begins with simple concordance coding in the left EBA, leading to the complex coding of social relevance in the left IFG/MFG.
https://ift.tt/2C3e0FI
Refining understanding of working memory buffers through the construct of binding: evidence from a single case informs theory and clinical practice
Publication date: Available online 27 August 2018
Source: Cortex
Author(s): Pierre-Yves Jonin, Clara Calia, Sophie Muratot, Serge Belliard, Quentin Duche, Emmanuel J. Barbeau, Mario A. Parra
Abstract
Binding operations carried out in working memory enable the integration of information from different sources during online performance. While available evidence suggests that working memory may involve distinct binding functions, whether or not they all involve the episodic buffer as a cognitive substrate remains unclear. Similarly, knowledge about the neural underpinnings of working memory buffers is limited, more specifically regarding the involvement of medial temporal lobe structures. In the present study, we report on the case of patient KA, with developmental amnesia and selective damage to the whole hippocampal system. We found that KA was unable to hold shape-colours associations (relational binding) in working memory. In contrast, he could hold integrated coloured shapes (conjunctive binding) in two different tasks. Otherwise, and as expected, KA was impaired on three relational memory tasks thought to depend on the hippocampus that are widely used in the early detection of Alzheimer's disease. Our results emphasize a dissociation between two binding processes within working memory, suggesting that the visuo-spatial sketchpad could support conjunctive binding, and may rely upon a large cortical network including sub-hippocampal structures. By contrast, we found evidence for a selective impairment of relational binding in working memory when the hippocampal system is compromised, suggesting that the long-term memory deficit observed in amnesic patients may be related to impaired short-term relational binding at encoding. Finally, these findings may inform research on the early detection of Alzheimer's disease as the preservation of conjunctive binding in KA is in sharp contrast with the impaired performance demonstrated very early in this disease.
https://ift.tt/2of5k5d
Left frontotemporal effective connectivity during semantic feature judgments in patients with chronic aphasia and age-matched healthy controls
Publication date: Available online 27 August 2018
Source: Cortex
Author(s): Erin L. Meier, Jeffrey P. Johnson, Swathi Kiran
Abstract
Traditional models of neural reorganization of language skills in patients with chronic stroke-induced aphasia (PWA) propose activation of reperfused or spared left hemisphere tissue results in the most favorable language outcomes. However, these models do not fully explain variable behavioral recovery patterns observed in chronic patients. Instead, investigation of connectivity patterns of critical network nodes may elucidate better-informed recovery models. In the present study, we combined fMRI and dynamic causal modeling (DCM) to examine effective connectivity of a simple three-node left hemisphere network during a semantic feature decision task in 25 PWA and 18 age-matched neurologically intact healthy controls. The DCM model space utilized in Meier, Kapse, & Kiran (2016), which was organized according to exogenous input to one of three regions (i.e., left inferior frontal gyrus, pars triangularis [LIFGtri], left posterior middle temporal gyrus [LpMTG], or left middle frontal gyrus [LMFG]) implicated in various levels of lexical-semantic processing, was interrogated. This model space included all possible combinations of uni- and bidirectional task-modulated connections between LIFGtri, LMFG and LpMTG, resulting in 72 individual models that were partitioned into three separate families (i.e., Family #1: Input to LIFGtri, Family #2: Input to LMFG, Family #3: Input to LpMTG). Family-wise Bayesian model selection revealed Family #2: Input to LMFG best fit both patient and control data at a group level. Both groups relied heavily on LMFG's modulation of the other two model regions. By contrast, between-group differences in task-modulated coupling of LIFGtri and LpMTG were observed. Within the patient group, the strength of activity in LIFGtri and connectivity of LpMTG→LIFGtri were positively associated with lexical-semantic abilities inside and outside of the scanner, whereas greater recruitment of LpMTG was associated with poorer lexical-semantic skills.
https://ift.tt/2wnp3UF
Alpha oscillations reveal implicit visual processing of motion in hemianopia
Publication date: Available online 27 August 2018
Source: Cortex
Author(s): Paolo A. Grasso, Mattia Pietrelli, Marco Zanon, Elisabetta Làdavas, Caterina Bertini
Abstract
After lesion or deafferentation of the primary visual cortex, hemianopic patients experience loss of conscious vision in their blind field. However, due to the spared colliculo-extrastriate pathway, they might retain the ability to implicitly process motion stimuli through the activation of spared dorsal-extrastriate areas, despite the absence of awareness. To test this hypothesis, EEG was recorded from a group of hemianopic patients without blindsight (i.e., who performed at chance in different forced-choice tasks), while motion stimuli, static stimuli or no stimuli (i.e., blank condition) were presented either in their intact or in their blind visual field. EEG analyses were performed in the time-frequency domain. The presentation of both motion and static stimuli in the intact field induced synchronization in the theta band and desynchronization both in the alpha and the beta band. In contrast, for stimuli presented in the blind field, significantly greater desynchronization in the alpha range was observed only after the presentation of motion stimuli, compared to the blank condition, over posterior parietal-occipital electrodes in the lesioned hemisphere, at a late time window (500-800 ms). No alpha desynchronization was elicited by static stimuli. These results show that hemianopic patients can process only visual signals relying on the activation of the dorsal pathway (i.e., motion stimuli) in the absence of awareness and suggest different patterns of electrophysiological activity for conscious and unconscious visual processing. Specifically, visual processing in the absence of awareness elicits an activity limited to the alpha range, most likely reflecting a "local" process, occurring within the extrastriate areas and not participating in inter-areal communication. This also suggests a response specificity in this frequency band for implicit visual processing. In contrast, visual awareness evokes changes in different frequency bands, suggesting a "global" process, accomplished by activity in a wide range of frequencies, probably within and across cortical areas.
https://ift.tt/2NqVCYe
No evidence for enhanced distractor template representation in early visual cortex
Publication date: Available online 27 August 2018
Source: Cortex
Author(s): Reshanne R. Reeder, Christian N.L. Olivers, Michael Hanke, Stefan Pollmann
https://ift.tt/2wlc7P1
Trichotillomania (hair pulling disorder): Clinical characteristics, psychosocial aspects, treatment approaches, and ethical considerations
Dermatologic Therapy, EarlyView.
https://ift.tt/2BUrd3v
Cyclosporine for corticosteroid‐refractory acute generalized exanthematous pustulosis due to hydroxychloroquine
Dermatologic Therapy, EarlyView.
https://ift.tt/2PP0AzU
Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα
[PDF] Analysis of oral health complications in diabetic patients–A diagnostic perspective.
S Mohanty, N Mohanty, S Rath - Journal of Oral Research, 2018
… Oral mucosal lesions like stomatitis, geographic tongue, benign migratory
glossitis, fissured tongue, traumatic ulcer, lichen planus and angular chelitis
have also been reported.4 Moreover, complications such as mucosal-neuro …
glossitis, fissured tongue, traumatic ulcer, lichen planus and angular chelitis
have also been reported.4 Moreover, complications such as mucosal-neuro …
 |  |  |
Neoplasms and non-neoplastic pathologies in the oral and maxillofacial regions in children and adolescents of a Brazilian population
CC da Silva Barros, LP da Silva, AKG Gonzaga… - Clinical Oral Investigations, 2018
… Immunological diseases Oral lichen planus 0 3 0 0 0 1 2 0 0 0 3 0.3 Pemphigus vulgaris
0 1 0 0 0 0 1 0 0 0 1 0.1 Migratory glossitis 0 1 0 0 0 1 0 0 0 0 1 0.1 Inflammatory/reactive
lesions Mucocele 137 325 28 1 362 53 10 0 0 8 462 46.9 …
0 1 0 0 0 0 1 0 0 0 1 0.1 Migratory glossitis 0 1 0 0 0 1 0 0 0 0 1 0.1 Inflammatory/reactive
lesions Mucocele 137 325 28 1 362 53 10 0 0 8 462 46.9 …
| | |
[PDF] Commensal and pathogen: Candida albicans
S Kaur, S Soni, R Singh
… There are some causative factors for denture stomatitis like poor oral hygiene,
nocturnal denture wear, ill fitting prostheses and restricted salivary
flow.(11,16,17) Median rhomboid glossitis: It is chronic symmetrical area …
nocturnal denture wear, ill fitting prostheses and restricted salivary
flow.(11,16,17) Median rhomboid glossitis: It is chronic symmetrical area …
| | |
[PDF] Cxcr-2 inhibitors for treating disorders
P Nanavati, J Hoegstedt, J Hall - US Patent App. 15/702,693, 2018
… pancreatitis, hepatic ischemia/reperfusion injury, acute alcoholic hepatitis,
necrotizing enterocolitis, chronic sinusitis, uveitis, polymyositis, vasculitis,
acne, gastric and duodenal ulcers, intestinal ischemia/reperfusion injury …
necrotizing enterocolitis, chronic sinusitis, uveitis, polymyositis, vasculitis,
acne, gastric and duodenal ulcers, intestinal ischemia/reperfusion injury …
| | |
cGAS ANTAGONIST COMPOUNDS
B Zhong, L Sun, H Shi, J Li, C Chen, Z Chen - US Patent App. 15/953,494, 2018
Disclosed are novel compounds of Formula I that are cGAS antagonists,
methods of preparation of the compounds, pharmaceutical compositions
comprising the compounds, and their use in medical therapy.
methods of preparation of the compounds, pharmaceutical compositions
comprising the compounds, and their use in medical therapy.
| | |
[PDF] Complementary and Alternative Treatments for Alopecia: A Comprehensive Review
AM Hosking, M Juhasz, NA Mesinkovska - Skin Appendage Disorders
Page 1. Review Article Skin Appendage Disord Complementary and Alternative
Treatments for Alopecia: A Comprehensive Review Anna-Marie Hosking Margit Juhasz
Natasha Atanaskova Mesinkovska Department of Dermatology …
Treatments for Alopecia: A Comprehensive Review Anna-Marie Hosking Margit Juhasz
Natasha Atanaskova Mesinkovska Department of Dermatology …
| | |
Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ
[HTML] Conocimientos sobre factores de riesgo de la estomatitis subprotesis en pacientes rehabilitados con prótesis mucosoportada
AMR Estévez, SE González, VOR Suárez - Medimay, 2018
… Knowledge about risk factors of sub prosthesis stomatitis in rehabilitated patients with
mucosoported prosthesis … ABSTRACT. Introduction: of sub prosthesis stomatitis is part
of the oral Health problems in the rehabilitated population with prosthesis …
mucosoported prosthesis … ABSTRACT. Introduction: of sub prosthesis stomatitis is part
of the oral Health problems in the rehabilitated population with prosthesis …
| | |
[HTML] Efecto de miconazol sobre el recuento de levaduras en candidiasis asociada a estomatitis protésica.
B Urzúa-Orellana, P Palma-Fluxá, JO Salinas-Flores… - Revista clínica de …, 2018
… Effect of miconazole on the yeast count in candidiasis associated with
denture stomatitis. Blanca Urzúa-Orellana 1. Patricia Palma-Fluxá 2 …
ABSTRACT: Introduction: Denture stomatitis is a chronic inflammatory …
denture stomatitis. Blanca Urzúa-Orellana 1. Patricia Palma-Fluxá 2 …
ABSTRACT: Introduction: Denture stomatitis is a chronic inflammatory …
| | |
[PDF] Clinical Application of An Integrated Operation System for Gathering Patient-Reported Outcomes of Chemotherapy Side Effects
H Yamamoto, Y Kitamura, K Yamaguchi - Japanese Journal of Applied IT Healthcare, 2018
… The target regimen for this study was chosen for a specific reason. The side effects targeted
for this study included "anorexia," "nausea," "vomiting," "fatigue," "constipation," "diarrhea,"
"stomatitis," "dysgeusia," and "allergies." … diarrhea 69.2 11.4 12.4 stomatitis 76.9 7.0 13.5 …
for this study included "anorexia," "nausea," "vomiting," "fatigue," "constipation," "diarrhea,"
"stomatitis," "dysgeusia," and "allergies." … diarrhea 69.2 11.4 12.4 stomatitis 76.9 7.0 13.5 …
| | |
Mutations in the nucleocapsid protein were complemented by mutations in the L protein to restore viral RNA synthesis
W Li, RH Gumpper, Y Uddin, I Schmidt-Krey, M Luo - Journal of Virology, 2018
… During viral RNA synthesis by the viral RNA-dependent RNA polymerase
(vRdRp) of vesicular 26 stomatitis virus, the sequestered RNA genome must
be released from the nucleocapsid in order 27 to serve as the template … 68 …
(vRdRp) of vesicular 26 stomatitis virus, the sequestered RNA genome must
be released from the nucleocapsid in order 27 to serve as the template … 68 …
| | |
Longitudinal nutritional assessment in hospitalized patients with head and neck cancer
M Kubota, Y Harada, H Saitoh, C Yamaguchi, M Omura - Clinical Nutrition, 2018
… starting chemo-radiation therapy (CRT). Results: Adverse events including stomatitis,
constipation, dysphagia, and taste abnormality appeared at 1 week and became
most prominent at 3e4 weeks. On the average of enrolled …
constipation, dysphagia, and taste abnormality appeared at 1 week and became
most prominent at 3e4 weeks. On the average of enrolled …
| | |
[PDF] Analysis of oral health complications in diabetic patients–A diagnostic perspective.
S Mohanty, N Mohanty, S Rath - Journal of Oral Research, 2018
… Oral mucosal lesions like stomatitis, geographic tongue, benign migratory
glossitis, fissured tongue, traumatic ulcer, lichen planus and angular chelitis
have also been reported.4 Moreover, complications such as mucosal-neuro …
glossitis, fissured tongue, traumatic ulcer, lichen planus and angular chelitis
have also been reported.4 Moreover, complications such as mucosal-neuro …
| | |
The nutritional status of an oncological patient prior to antitumor treatment
O Obukhova, A Snegovoy, E Khichina, S Kashiya - Clinical Nutrition, 2018
… Most of them (34%) could not explain the reason of WL, 31% reported nausea/vomiting,
19% referred to anorexia; 13% showed consequences of CT toxicity (dysgeusia,
stomatitis), 3% could not eat properly due to the pain syndrome …
19% referred to anorexia; 13% showed consequences of CT toxicity (dysgeusia,
stomatitis), 3% could not eat properly due to the pain syndrome …
| | |
Development of Duplex Fluorescence-based Loop-mediated Isothermal Amplification Assay for Detection of Mycoplasma bovis and Bovine Herpes Virus 1
Q Fan, Z Xie, Z Xie, L Xie, J Huang, Y Zhang, T Zeng… - Journal of Virological …, 2018
… BVDV bovine virus diarrhoea virus. BPI3 bovine parainfluenza type 3. FMDV
foot-and-mouth disease virus. VSV vesicular stomatitis virus. RPV … Vesicular stomatitis
virus (VSV), 2 serotypes (New Jersey, Indiana) of inactivated viruses, YNCIQ …
foot-and-mouth disease virus. VSV vesicular stomatitis virus. RPV … Vesicular stomatitis
virus (VSV), 2 serotypes (New Jersey, Indiana) of inactivated viruses, YNCIQ …
| | |
[PDF] SISTEM PAKAR BERBASIS ANDROID UNTUK DIAGNOSA PENYAKIT GIGI DAN MULUT
HS Arfajsyah, I Permana, FN Salisah - Jurnal Ilmiah Rekayasa dan Manajemen …, 2018
… Sedangkan pada penelitian ini, penyakit-penyakit yang dipilih adalah penyakit-
penyakit yang benar-benar bisa didiagnosa awal oleh orang awam
berdasarkan gejala-gejala yang tersedia, seperti penyakit: (1) karies gigi; …
penyakit yang benar-benar bisa didiagnosa awal oleh orang awam
berdasarkan gejala-gejala yang tersedia, seperti penyakit: (1) karies gigi; …
| | |
[HTML] Multimodality Treatment of a Colorectal Cancer Stage IV Patient with FOLFOX-4, Bevacizumab, Rigvir Oncolytic Virus, and Surgery
A Tilgase, E Olmane, J Nazarovs, L Brokāne… - Case Reports in …, 2018
… Oncolytic vesicular stomatitis virus has been tested in 2 models in immune competent
rats using a colorectal cancer cell line. In the liver metastases model, vesicular stomatitis
virus caused an increase in median overall survival compared to control (110 vs. 25 days) …
rats using a colorectal cancer cell line. In the liver metastases model, vesicular stomatitis
virus caused an increase in median overall survival compared to control (110 vs. 25 days) …
| | |
Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
Εγγραφή σε:
Αναρτήσεις (Atom)
-
Summary Insulinomas are rare neuroendocrine tumours that classically present with fasting hypoglycaemia. This case report discusses an un...
-
The online platform for Taylor & Francis Online content New for Canadian Journal of Remote Sen...
