Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers

Abstract

Purpose

This Phase I study estimated the effect of a high-fat meal on the pharmacokinetics (PK) of H3B-6527, a covalent inhibitor of the fibroblast growth factor receptor (FGFR) 4 in clinical development for hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Methods

In this randomized, single center, single-dose, open-label, 2-period crossover study 12 healthy male volunteers, aged 18–55 years old, received a single 200-mg dose of H3B-6527 (capsule) following an overnight fast or a high-fat breakfast. PK samples were collected serially up to 36 h postdose. H3B-6527 concentrations were measured using a validated high-performance liquid chromatography tandem mass spectrometry method. PK data were analyzed using a noncompartmental approach based on a mixed-effects model. The safety and tolerability of H3B-6527 were also assessed.

Results

H3B-6527 plasma exposure increased after a high-fat meal with fed/fasted ratios of the geometric means (90% confidence interval) of 174% (102–298%) for C_max and 246% (146–415%) for AUC_0–t. Food delayed and prolonged absorption of H3B-6527, with a fed/fasted ratio for t_max of 200% (137–263%). PK variability was lower under the fed condition, as illustrated by the CV% for C_max and AUC_0–t of 41.9–54.5% (fed) versus 64.3–70.4% (fasted).

Conclusions

A single 200 mg dose of H3B-6527 was safe and generally well tolerated when administered to healthy adult males. A high-fat meal significantly increased exposure to H3B-6527, from 1.5- to 2.5-fold in the systemic circulation, compared to administration under fasted conditions. Food delayed and prolonged absorption of H3B-6527. In general, lower inter-subject variability was observed in the fed state in healthy volunteers.

Trial registration

ClinicalTrials.gov.: NCT03424577.

https://ift.tt/2D4LcfH

A High Alanine Aminotransferase/Aspartate Aminotransferase Ratio Determines Insulin Resistance and Metabolically Healthy/Unhealthy Obesity in a General Adult Population in Korea: The Korean National Health and Nutritional Examination Survey 2007–2010

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0752-0217

Aims Early identification of individuals with insulin resistance (IR) and metabolically unhealthy state can help prevent various diseases and improve quality of life. In this study, we investigated a possible marker of IR and metabolic health status, alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio, and aimed to confirm its feasibility in a large population study. Methods A total of 16,371 adults from Korean National Health and Examination Survey were studied. Participants were divided into four groups according to their ALT/AST ratio quartiles. The homeostatic model assessment of insulin resistance level and proportion of people with IR, impaired fasting glucose, and undiagnosed type 2 diabetes were compared for each group. Receiver-operating characteristics (ROC) curve was also used to assess the usefulness of ALT/AST ratio to identify individuals with IR and metabolically unhealthy. Results In the groups with higher ALT/AST ratio, HOMA-IR level, proportion of IR, and proportion of individuals with IFG or type 2 diabetes mellitus was higher than that in those with low ALT/AST ratio. When analyzed with other factors related to IR, the data showed that the ALT/AST ratio was an independent predictor of IR (odds ratio 1.363, 95% confidential interval 1.323–1.405, p<0.001). When ROC curve analysis was done, area under curve (AUC) for identifying individuals with IR was 0.634. In addition, metabolically unhealthy individuals showed significantly higher ALT/AST ratio than metabolically healthy individuals (0.9780 vs 0.8511, p<0.001). Conclusions ALT/AST ratio was well-correlated with IR, IR-related conditions, and metabolic health status. This easily accessible method to estimate IR may facilitate the early screening of IR, which can result in prevention of IR-related morbid conditions.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Do-It-Yourself Microsuture from Human Hair for Basic Microsurgical Training

J reconstr Microsurg
DOI: 10.1055/s-0038-1675203

Background Microsuture is an essential material for basic microsurgical training. However, it is consumable, expensive, and sometimes unavailable in the microsurgical laboratory. To solve this problem, we developed a microsuture made from human hair and needle gauge. Methods Do-It-Yourself (DIY) microsuture is made from human hair and needle gauge 32G (BD Ultra-Fine Pen Needles 4 mm × 32G). Methods are explained step by step. This DIY microsuture (labeled as "test microsuture") and nylon 8–0 (Ethilon suture 8–0, labeled as "standard microsuture") were used for teaching orthopaedic residents to perform arterial anastomosis in chicken thighs. All residents practiced without knowing that "test microsuture" was made from the DIY method. After completing the training, quality of both microsutures was evaluated by questionnaire in topics of (1) thread quality (size, strength, elasticity, handing, knot perform, and knot security), (2) needle quality (size, curve, shape, sharpness, handling, and strength), (3) needle–thread interface (size, strength, and smoothness), and (4) overall quality of microsuture. Each category was evaluated by Likert score (5 = excellent, 4 = good, 3 = fair, 2 = poor, and 1 = very poor). Results The DIY microsuture was performed in three steps: (1) insert human hair into needle gauge by microforceps, (2) bend needle into smooth curve, and (3) disconnect needle and create needle–hair interface. The questionnaire was completed by 30 orthopaedic residents and showed that thread quality of DIY and standard microsuture had "good" and "good-to-excellent" quality (mean Likert score: 3.77–4.23 and 3.80–4.27, respectively, with no statistical difference). Thread–needle interface quality of DIY and standard microsuture also had "good" and "good-to-excellent" quality (Likert score: 3.73–4.20 and 4.07–4.33, respectively, with no statistical difference). Needle part of DIY microsuture had lower quality than standard suture (fair-to-good compared with good-to-excellence quality, score 3.30–3.67 vs. 4.20–4.27, respectively, with a statistically significant difference, p-value < 0.05). However, overall quality of DIY suture and standard microsuture had "good" and "good-to-excellent" (mean Likert score: 3.73 and 4.00, respectively, with no statistical difference). Conclusion The DIY microsuture from human hair and needle gauge could be an alternative for basic microsurgical training with lower cost, easy production, and more availability for use in practice with acceptable quality compared with that of standard microsuture.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Failure to Accurately Disclose Conflicts of Interest in Articles Published in JAMA Oncology

To the Editor I write to take full responsibility for failing to report appropriate conflicts of interest disclosures in articles published in JAMA Oncology and the JAMA Network journals between 2015 and 2018, including 5 articles published in JAMA Oncology. In 3 of these article I had reported receiving personal fees from Roche, and in 2 articles I had reported nothing to disclose. In the interest of full disclosure, I now report the following financial interests and activities that I had been involved from 2013 to the present time, regardless of potential relevance:

https://ift.tt/2EGYnVw

Missing Conflict of Interest Disclosure

In a number of articles published in JAMA Oncology, conflict of interest disclosures were not reported accurately by José Baselga, MD, PhD. Dr Baselga has written a Letter to the journal explaining this inconsistent reporting of potential conflict of interest disclosures. All articles have been corrected online.

https://ift.tt/2D7aPfA

Pakistan’s quest for coal-based energy under the China-Pakistan Economic Corridor (CPEC): implications for the environment

https://ift.tt/2SmVtbw

Grain size analysis of California waterbodies to determine the spatial extent and temporal trends of depositional areas where hydrophobic organic compounds could accumulate

Abstract

The objective of this study was to summarize the grain size data from 1993 to 2016 from California water bodies and determine the number and percent of sites where sediment samples are primarily depositional sediment (more than 50% silt/clay) or non-depositional sediment (less than 50% silt/clay). Fine grain depositional areas were of interest because these are areas where hydrophobic organic compounds (HOCs) can accumulate if sources exist. Trends analysis of percent silt/clay data were conducted for all nine California Water Board Regions if adequate data for this type of analysis were available. Sediment sampling protocols were reviewed for all the grain size measurements to determine if depositional areas were targeted or random sampling was conducted. Twelve of the 13 sediment sampling protocols targeted depositional areas. Based on 23 years of data from 685 sites (1859 observations) in all 9 California Regions, the summary analysis showed that only 58% of the sites were considered depositional areas even when targeted sampling for depositional areas was used. Since only slightly more than half the sites were reported as depositional areas based on sampling that targets depositional areas, these results would certainly suggest that depositional areas are not dominant. In fact, for the one protocol where random sampling was used, depositional areas were not reported to be dominant. From an ecological risk perspective, the implication of this finding is that HOCs would not be expected to accumulate in the dominant type of sediment found in most California waterbodies. Trends analysis of percent silt/clay data showed mixed results for the various California Regions.

https://ift.tt/2z5W2xv

Enhancement of visible-light photocatalytic activities of BiVO 4 coupled with g-C 3 N 4 prepared using different precursors

Abstract

Graphitic-like carbon nitride (g-C₃N₄) photocatalyst was synthesized by a facile chemical pyrolysis method, which was built on the self-condensation of different precursors to generate g-C₃N₄, e.g., melamine, urea, and thiocarbamide. And the different precursors produced a great influence on the photocatalytic activities of g-C₃N₄. Heterojunctions of g-C₃N₄ and BiVO₄ were synthesized using a facile solvent evaporation method. The formation of BiVO₄/g-C₃N₄ composites were confirmed by XRD, FT-IR, SEM, XPS, and UV-Vis DRS. The photocatalytic activities for RhB degradation were evaluated under visible-light irradiation. The photocatalytic activity of g-C₃N₄ prepared by urea was higher than that of g-C₃N₄ prepared by melamine and thiocarbamide, which was attributed to its favorable dispersibility, larger specific surface area, and higher oxidation capacity. The heterojunction composites exhibited higher photocatalytic activity than pure g-C₃N₄ or BiVO₄. The results showed obvious removal efficiency for RhB, and the optimal sample with a BiVO₄ content of 10% exhibited higher efficiency than pure g-C₃N₄ and BiVO₄, and 10 wt%BiVO₄/CN-U showed the highest photocatalytic activity. The enhanced photocatalytic activity of BiVO₄/g-C₃N₄ composite can be attributed to the intimate coupling between the two host substrates, resulting in an efficient charge separation.

https://ift.tt/2SozAsn

Atmospheric monitoring of organochlorine pesticides across some West African countries

Abstract

Most African countries have ratified the Stockholm Convention on persistent organic pollutants (POPs) and are expected to reduce emissions of POPs such as organochlorine pesticides (OCPs) to the atmosphere. Emerging evidence, however, suggests that there are contemporary sources of OCPs in African countries despite the global ban on these products. This study investigated the atmospheric contamination from OCPs in four West African countries—Togo, Benin, Nigeria, and Cameroon—to ascertain the emission levels of OCPs and the characteristic signatures of contamination. Polyurethane foam (PUF) disk passive air samplers (PAS) were deployed in each country for ca. 55 days in 2012 and analyzed for 25 OCPs. Hexachlorocyclohexanes (HCHs) and DDTs constituted the highest burden of atmospheric OCPs in the target countries, at average concentrations of 441 pg m⁻³ (range 23–2718) and 403 pg m⁻³ (range 91–1880), respectively. Mirex had the lowest concentration, ranged between 0.1 and 3.3 pg m⁻³. The concentration of OCPs in rainy season was higher than in dry season in Cameroon, and presupposed inputs from agriculture during the rainy season. The concentrations of ∑25 OCPs in each country were in the following order: Cameroon > Nigeria > Benin > Togo. There was significant evidence, based on chemical signatures of the contamination that DDT, aldrin, chlordane, and endosulfan were recently applied at certain sites in the respective countries.

https://ift.tt/2z6yjgE

Assessment the activity of magnetic KOH/Fe 3 O 4 @Al 2 O 3 core–shell nanocatalyst in transesterification reaction: effect of Fe/Al ratio on structural and performance

Abstract

Recently, biodiesel production using heterogeneous catalysts has been of great concern. However, simple separation of these catalysts from product mixtures is a problem of the process. In this study, series of magnetic KOH/Fe₃O₄@Al₂O₃ core–shell nanocatalysts were synthesized via the incipient wetness impregnation method and the effect of weight ratio of Fe₃O₄-to-Al₂O₃ (0.15–0.35) on the catalytic performance was assessed. The samples were characterized by XRD, FTIR, BET-BJH, VSM, SEM, TEM, and EDX analyses and their basicity was measured by the Hammett indicator method. The results revealed that although the magnetic KOH/Fe₃O₄@Al₂O₃ nanocatalyst with 25 wt% of Fe₃O₄ showed less activity as compared to those with 15 wt% of Fe3O4, it exhibited higher surface area and appropriate magnetic properties. The sample presented superparamagnetic properties with the magnetic strength of 1.25 emu/g that was simply recovered by using an external magnetic field. The nanocatalyst converted 98.8% of canola oil to biodiesel under reflux condition at the best operational conditions of 12 M ratio of methanol/oil, 4 wt% of catalyst and 6 h of reaction time. Moreover, the nanocatalyst showed high reusability such that it was reused several times without appreciable loss of its catalytic activity.

https://ift.tt/2Sozq4f

Cleaner emissions from a DI-diesel engine fueled with mahua oil and low carbon ethanol-hydrogen in dual fuel mode

Abstract

This work is all about utilization of more than two low carbon fuels in a diesel engine with a main objective of reducing harmful emissions. Initially, test engine was tested with a non-petroleum-based fuel namely mahua oil, under different load conditions. In the second phase of the work, test engine was modified into dual fuel mode with slight modification in the intake manifold for the admission of a low carbon high octane primary fuel namely ethanol. The engine was tested by varying the ethanol energy share (EES) from 5% to the point at which engine tends to knock at 100% and 40% of the maximum engine power output. Finally, an attempt was made to induct a zero carbon high octane fuel (i.e., hydrogen) in the intake manifold of the dual fuel engine operated with mahua and ethanol and tested for the behavior. Experimental results claimed that inclusion of ethanol improved the brake thermal efficiency (BTE) only at the higher loads. Optimized EES at 100% load conditions was identified as 15%. It is found that injection of ethanol significantly reduced the harmful emissions like smoke and oxides of nitrogen at the price of increased hydrocarbon and carbon monoxide emissions. It is also inferenced that BTE was improved further with the increases of hydrogen flow rate at peak load. Interestingly all the carbon-based emissions were drastically reduced with the inclusion of hydrogen. However, the oxides of nitrogen emission were found to be increased with increase of hydrogen flow rate.

https://ift.tt/2z93iIH

Adolescent-Onset Hidradenitis Suppurativa: Prevalence, Risk Factors and Disease Features

Background/Aims: Hidradenitis suppurativa (HS) is a chronic inflammatory and destructive skin disorder. Early diagnosis and treatment are critical to stop its progression. Data concerning adolescent-onset HS are scarce. The aims of this study are to describe the prevalence of adolescent-onset HS and to explore potential risk factors and the disease features of these patients. Patients and Methods: A cross-sectional study including 134 patients was performed. Results: Adolescent-onset HS occurred in 51.5% (69/134) of patients. Adolescent-onset HS was associated with female sex, positive family history, presence of pilonidal sinus, acne conglobata, longer disease duration and a worse perception of disease severity. Conclusion: Adolescent-onset HS might be more frequent than previously reported. Female sex, positive family history and the presence of elements of the follicular occlusion tetrad identify individuals with a higher risk of early onset. These patients experience a longer disease duration and perceive their disease as severer.
Dermatology

https://ift.tt/2CGMqws

Standardized Photographic Documentation of Hidradenitis Suppurativa/Acne Inversa

Background: Despite existing guidelines and methods for standardized clinical photography in dermatology and plastic surgery, human skin exhibits exquisite site-specific morphologies and functions, and each body region can exhibit an individual pathologic phenotype. The aim of this work was to develop a standardized, representative and reproducible documentation of the multilocular hidradenitis suppurativa/acne inversa (HS) lesions, a disease mostly occurring in skin folds. Method: Optimal body positions for medical photography of candidate areas for HS involvement were evaluated. Pictures of volunteers were taken, and indicative scientific graphics were designed. Results: Due to the variability of HS lesions and the fact of their localization in skin folds, a standardized, reproducible photographic documentation of HS candidate skin areas (50 cm from the skin surface) is proposed. The photographic series includes: (1) right armpit, (2) left armpit, (3) right groin, (4) left groin, (5) genital area, (6) anal area and anal fold, (7) right buttock, (8) left buttock, (9) chest area, (10) mons pubis, (11) right submammary area (females), (12) left submammary area (females). The protocol is accompanied with indicative scientific graphics for photography-proper positioning of the relevant body parts for documentation of potentially flat skin areas. In addition, former proposals for technical standardization of photography in dermatology, regarding instrumentation, environmental lighting and background colour, have to be respected. Conclusion: Standardized photography of candidate skin areas for HS involvement will allow longitudinal intraindividual and interindividual evaluation of the disease course as well as prospective and retrospective comparative studies.
Dermatology

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Conservative Treatment of Retronychia: A Retrospective Study of 25 Patients

No abstract available

https://ift.tt/2PXkNDf

CA209-891: Neoadjuvant and Adjuvant Nivolumab as Immune Checkpoint Inhibition in Oral Cavity Cancer

Condition:   Squamous Cell Carcinoma of the Oral Cavity
Interventions:   Biological: Nivolumab, Surgery, Radiotherapy;   Biological: Nivolumab, Surgery, Chemoradiotherapy
Sponsors:   The Clatterbridge Cancer Centre NHS Foundation Trust;   University of Liverpool;   Bristol-Myers Squibb
Not yet recruiting

https://ift.tt/2PVgTKY

Regorafenib Combined With Irinotecan as Second-line in Patients With Metastatic Gastro-oesophageal Adenocarcinomas

Conditions:   Adenocarcinoma of the Stomach;   Adenocarcinoma of the Gastroesophageal Junction
Interventions:   Combination Product: Regorafenib and Irinotecan;   Drug: Irinotecan
Sponsor:   UNICANCER
Not yet recruiting

https://ift.tt/2AsBt07

Treatment of Hypertrophic Scars Using Laser-Assisted Corticosteroid Versus Laser-Assisted 5-Fluorouracil Delivery

BACKGROUND As the mortality of individuals suffering severe cutaneous injuries decreases, there is an increased need to improve the methods by which physicians treat the resultant scars. Fractional lasers, which create zones of ablation at variable depths, provide a powerful tool in the management of scar complications and deformities. After disruption of the normal skin barrier, these zones may be used to deliver drugs that may enhance scar resolution. OBJECTIVE To determine the differences in clinical outcome for hypertrophic scars treated with laser-assisted corticosteroid delivery, as compared to laser-assisted 5-fluorouracil delivery. METHODS In this prospective, double-blinded, single-subject study of 20 individuals with hypertrophic scars, subjects underwent 3 treatment sessions at 1-month intervals consisting of fractional ablative laser treatment, followed by postoperative application of either topical triamcinolone acetonide (20 mg/mL) or topical 5-fluorouracil (50 mg/mL). RESULTS Three sessions of laser-assisted triamcinolone acetonide and 5-fluorouracil delivery both produced reductions in overall scar area. When compared with one another, there were no statistically significant differences in area reduction between the 2 modalities (p = .603). However, scars treated with 5-fluorouracil were not associated with side effects seen with corticosteroid therapy, such as dermal atrophy or telangiectasia formation. CONCLUSION As 5-fluorouracil was associated with fewer adverse events, these findings support the use of a nonsteroidal agent in the management of traumatic scars by laser-assisted therapy. Address correspondence and reprint requests to: Jill S. Waibel, MD, Miami Dermatology and Laser Institute, Miami, Florida 33173, or e-mail: jwaibelmd@miamidermlaser.com Supported by a Cutting Edge Research Grant from the American Society for Dermatologic Surgery. The authors have indicated no significant interest with commercial supporters. © 2018 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Erosive pustular dermatosis of the scalp: a neutrophilic folliculitis within the spectrum of neutrophilic dermatoses. A clinicopathologic study of thirty cases

Publication date: Available online 25 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Carlo Tomasini, Andrea Michelerio

Abstract

Background

It is general opinion that histopathology is nonspecific and of little value in diagnosing erosive pustular dermatosis of the scalp (EPDS).

Objectives

Clinicopathologic correlation of erosive pustular dermatosis of the scalp.

Methods

The clinical and pathological records of patients with a clinicopathologic diagnosis of EPDS, between 2011-2016, at the Dermatopathology Unit of the Turin University were reviewed.

Results

Thirty elderly patients with EPDS were identified, 22 males and 8 females. Androgenetic alopecia was present in 19/30 patients. Triggering factors included mechanical trauma in 10/30 cases, surgical procedures in 4/30, herpes zoster in 1/30. Three patients were affected by autoimmune disorders. The vertex was the most common location. Disease presentation varied markedly from tiny, erosive, scaly lesions to crusted and hemorrhagic plaques, mimicking pustular pyoderma gangrenosum. The pathologic changes differed according to the lesion type and disease duration. Interestingly, a spongiotic and suppurative infundibulo-folliculitis was observed in 8/30 cases.

Limitations

This was a retrospective study.

Conclusions

We believe that the primary lesion of erosive pustular dermatosis of the scalp is a spongiotic, pustular superficial folliculitis. The clinicopathologic similarities with other neutrophilic dermatoses, such as pustular pyoderma gangrenosum, suggest this condition should be included in this spectrum, where pathergy plays a pathogenetic role.

https://ift.tt/2qf12Md

Effect of Post-Injection Facial Exercise on Time of Onset of Botulinum Toxin for Glabella and Forehead Wrinkles: A Randomized Controlled, Crossover Clinical Trial

Publication date: Available online 25 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Murad Alam, Amelia Geisler, Melanie Warycha, Kapila Paghdal, Wanjarus Roongpisuthipong, Daniel I. Schlessinger, Brian R. Chen, Kelly A. Reynolds, Dennis P. West, Emily Poon

https://ift.tt/2CJenUC

Development and Implementation of an Order Set to Improve Value of Care for Patients with Severe Stasis Dermatitis

Publication date: Available online 25 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Susan Nedorost, Sheree White, Douglas Y. Rowland, Beth Bednarchik, Susan Flocke, Teresa L. Carman, Lauren Karpinski, Yiwen Shi

https://ift.tt/2qf10E5

Scholar : Theatre, Dance and Performance Training, Volume 9, Issue 3, October 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Theatre, Dance and Performance Training, Volume 9, Issue 3, October 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Editorial Editorial Simon Murray, Libby Worth, Bryan Brown & Dick McCaw Pages: 299-306 | DOI: 10.1080/19443927.2018.1505021 Articles Peter Hulton on Dartington College of Arts Bryan Brown & Peter Hulton Pages: 307-313 | DOI: 10.1080/19443927.2018.1504815 A school for adventure: the journeys of Dartington College of Arts Misha Myers Pages: 314-323 | DOI: 10.1080/19443927.2018.1500940 Graham Green Pages: 324-325 | DOI: 10.1080/19443927.2018.1532700 Explorations at the edge: memories of art and dance at Dartington in the Thatcher years Chris Crickmay Pages: 326-336 | DOI: 10.1080/19443927.2018.1478322 Miscellany Answer the Question Tanya Myers Pages: 337-338 | DOI: 10.1080/19443927.2018.1511143 Postcard Joe Richards Pages: 339-339 | DOI: 10.1080/19443927.2018.1522849 Postcards Emma Gee Pages: 340-340 | DOI: 10.1080/19443927.2018.1522865 Postcard Dr. Diana Theodores Pages: 341-341 | DOI: 10.1080/19443927.2018.1522859 Postcards Fabio Cicala Pages: 342-342 | DOI: 10.1080/19443927.2018.1522866 Postcard Bethany Murray Pages: 342-342 | DOI: 10.1080/19443927.2018.1522854 Answer the Question Bethany Murray Pages: 343-343 | DOI: 10.1080/19443927.2018.1511167 Answer the Question Barbara Bridger Pages: 344-344 | DOI: 10.1080/19443927.2018.1511154 Articles A quietness of training Adam Strickson Pages: 345-357 | DOI: 10.1080/19443927.2018.1500941 Dance in the 1970s ‒ a crucible for de-schooling: releasing into being danced Linda Hartley Pages: 358-366 | DOI: 10.1080/19443927.2018.1479295 Miscellany Postcard Emilyn Claid Pages: 367-367 | DOI: 10.1080/19443927.2018.1522863 Postcard Angus Balbernie Pages: 368-368 | DOI: 10.1080/19443927.2018.1522852 Articles Dartington: a reflection of the training Amanda Brennan Pages: 369-372 | DOI: 10.1080/19443927.2018.1500942 The question is not … Andy Smith Pages: 373-379 | DOI: 10.1080/19443927.2018.1478880 Radical connections: the Dartington Dance Festival/X6 Dance Space axis Jacky Lansley & Fergus Early Pages: 380-388 | DOI: 10.1080/19443927.2018.1482230 Miscellany Answer the Question Emma Gee Pages: 389-390 | DOI: 10.1080/19443927.2018.1511169 Answer the Question Simon Persighetti Pages: 391-392 | DOI: 10.1080/19443927.2018.1511168 Answer the Question Trevor Wiggins, Griselda Sanderson, Frank Denyer, Catherine Laws & David Prior Pages: 393-395 | DOI: 10.1080/19443927.2018.1511166 Postcard Frank Denyer Pages: 396-397 | DOI: 10.1080/19443927.2018.1522848 Postcards Sam Richards Pages: 397-397 | DOI: 10.1080/19443927.2018.1522851 Postcards Postcard Pages: 398-398 | DOI: 10.1080/19443927.2018.1523530 Miscellany Answer the Question Melanie Thompson Pages: 399-400 | DOI: 10.1080/19443927.2018.1511082 Answer the Question Pages: 401-402 | DOI: 10.1080/19443927.2018.1511139 Articles A Dartington Timeline: Ninety Years of Small Print. Kate Mount and Kevin Mount Pages: 403-409 | DOI: 10.1080/19443927.2018.1523532 Walking to Dartington Donna Shilling Pages: 410-416 | DOI: 10.1080/19443927.2018.1470108 These people, this time, this place: a conversation about Dartington as methodology Avia Moore & Sarah Ashford Hart Pages: 417-421 | DOI: 10.1080/19443927.2018.1500937 Other 'Does this house hold?' Misha Myers Pages: 422-422 | DOI: 10.1080/19443927.2018.1522845 Answer the Question Answer the Question Jonathan Stone Pages: 423-425 | DOI: 10.1080/19443927.2018.1523524 Miscellany Answer the Question Pages: 426-427 | DOI: 10.1080/19443927.2018.1511162 Answer the Question Pages: 428-429 | DOI: 10.1080/19443927.2018.1511161 Answer the Question Pages: 430-430 | DOI: 10.1080/19443927.2018.1511160 Articles Here we are, let's go: Dartington College of Arts, 14 June 1997, Studio 11, 6.30 pm. A revision of Lone Twin's On Everest Gregg Whelan Pages: 431-444 | DOI: 10.1080/19443927.2018.1503615 The potentiality of collaboration at Dartington College of Arts and the future of performance training Noyale Colin Pages: 445-456 | DOI: 10.1080/19443927.2018.1500938 'My aunt was always doing wild things': the long-term impact of Dartington Theatre Training on theatre and community in south-east London 1978–2017 David Slater Pages: 457-463 | DOI: 10.1080/19443927.2018.1500939 Notes on Contributors Notes on Contributors Pages: 464-468 | DOI: 10.1080/19443927.2018.1505020 Routledge Performance Archive - https://ift.tt/1txaJgs "Take a Tour" to find out more and recommend the Archive to your librarian to arrange a free trial for your institution. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Comparison of Monitor-Image and Printout-Image Methods in Ki-67 Scoring of Gastroenteropancreatic Neuroendocrine Tumors

Abstract

Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are classified according to tumor grade. Ki-67 and mitotic count are the two determinants of this classification. Therefore, Ki-67 scoring becomes very important in classifying the patients accurately. Eye-balling, counting of cells through the microscope, automated image analysis systems, and manual counting of printed image are the four major scoring methods in use. The aim of this study is to show the agreement between monitor-image method (MIM) and printout-image method (PIM) of Ki-67 scoring. In our study, 120 GEP-NETs from 85 patients diagnosed between January 2005 and July 2017 were evaluated. Thirty-seven cases with either polypectomy or resection material were selected. Seven different scoring methods using either a monitor-image or a printout-image were applied for Ki-67 scoring. They are as follows: whole-PIM, 1/9-PIM, whole-MIM, 1/4-MIM, 1/6-MIM, 1/9-MIM, and 1/12-MIM. In the comparison of Ki-67 scoring methods, intraclass correlation coefficients ranging from 0.951 to 0.999 were found. The Bland-Altman analysis showed near-perfect agreement between whole-MIM and whole-PIM as well as 1/9-MIM and 1/9-PIM. The level of agreements among the other methods were sufficient too, but there was a relative decrease in the level of agreement as the area of counting becomes smaller. The average application time decreased from 373.7 to 41.7 s gradually as the scoring area becomes smaller. Our study shows that there is a remarkable agreement between the MIM and PIM used in Ki-67 scoring.

https://ift.tt/2RgHbrh

Editorial Board

Publication date: November 2018

Source: Autoimmunity Reviews, Volume 17, Issue 11

Author(s):

https://ift.tt/2CD4tUp

Pheochromocytoma in Congenital Cyanotic Heart Disease.

Pheochromocytoma in Congenital Cyanotic Heart Disease.

Case Rep Endocrinol. 2018;2018:2091257

Authors: Aresta C, Butera G, Tufano A, Grassi G, Luzi L, Benedini S

Abstract
Studies on genome-wide transcription patterns have shown that many genetic alterations implicated in pheochromocytoma-paraganglioma (P-PGL) syndromes cluster in a common cellular pathway leading to aberrant activation of molecular response to hypoxia in normoxic conditions (the pseudohypoxia hypothesis). Several cases of P-PGL have been reported in patients with cyanotic congenital heart disease (CCHD). Patients affected with CCHD have an increased likelihood of P-PGL compared to those affected with noncyanotic congenital heart disease. One widely supported hypothesis is that chronic hypoxia represents the determining factor supporting this increased risk. We report the case of a 23-year-old woman affected with congenital tricuspid atresia surgically by the Fontan procedure. The patient was admitted to hospital with hypertensive crisis and dyspnea. Chest computed tomography revealed, incidentally, a 6-cm mass in the left adrenal lodge. Increased levels of noradrenaline (NA) and its metabolites were detected (plasma NA 5003.7 pg/ml, n.v.<480; urinary NA 1059.5 µg/24 h, n.v.<85.5; urinary metanephrine 489 µg/24 h, n.v.<320). The patient did not report any additional symptom related to catecholamine excess. The left adrenal tumor showed abnormal accumulation when 131I-metaiodobenzylguanidine scintigraphy was performed. A 18F-fluorodeoxyglucose positron emission tomography showed no significant metabolic activity in the left adrenal gland but intense uptake in the supra- and subdiaphragmatic brown adipose tissue, probably due to noradrenergic-stimulated glucose uptake. The patient underwent left open adrenalectomy after preconditioning with α- and β-blockers and histopathological examination confirmed the diagnosis of pheochromocytoma (Ki-67<5%). Screening for germline mutations did not show any genes mutation (investigated mutations: RET, TMEM127, MAX, SDHD, SDHC, SDHB, SDHAF2, SDHA, and VHL). Clinicians should consider P-PGL when an unexplained clinical deterioration occurs in CCHD patients, even in the absence of typical paroxysmal symptoms.

PMID: 30356369 [PubMed]

https://ift.tt/2O7QqYU

Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism.

Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism.

Case Rep Endocrinol. 2018;2018:8270936

Authors: Sandhu S, Desai A, Batra M, Girdhar R, Chatterjee K, Kemp EH, Makdissi A, Chaudhuri A

Abstract
We report the case of a 54-year-old Caucasian female who presented with a two-year history of persistent hypocalcemia requiring multiple hospitalizations. Her medical history was significant for HIV diagnosed four years ago. She denied any history of prior neck surgery or radiation. Her vital signs were stable with an unremarkable physical exam. Pertinent medications included calcium carbonate, vitamin D3, calcitriol, efavirenz, emtricitabine, tenofovir disoproxil, hydrochlorothiazide, and inhaled budesonide/formoterol. Laboratory testing showed total calcium of 5.7 mg/dL (normal range: 8.4-10.2 mg/dL), ionized calcium of 2.7 mg/dL (normal range: 4.5-5.5 mg/dL), serum phosphate of 6.3 mg/dL (normal range: 2.7-4.5 mg/dL), and intact PTH of 7.6 pg/mL (normal range: 15-65 pg/mL). She was diagnosed with primary hypoparathyroidism. Anti-calcium-sensing receptor antibodies and NALP5 antibodies were tested and found to be negative. During subsequent clinic visits, doses of calcium supplements and calcitriol were titrated. Last corrected serum calcium level was 9.18 mg/dL. She was subsequently lost to follow-up. This case gives insight into severe symptomatic hypocalcemia from primary hypoparathyroidism attributed to HIV infection. We suggest that calcium levels should be closely monitored in patients with HIV infection.

PMID: 30356346 [PubMed]

https://ift.tt/2OP8uMB

Early assessment of acute kidney injury using targeted field of view diffusion-weighted imaging: An in vivo study

Publication date: Available online 25 October 2018

Source: Magnetic Resonance Imaging

Author(s): Hanjing Kong, Chengyan Wang, Fei Gao, Xiaodong Zhang, Min Yang, Li Yang, Xiaoying Wang, Jue Zhang

Abstract

Acute kidney injury (AKI) is a common complication in various clinical settings. In recent years, AKI diagnostics have been investigated intensively showing the emerging need for early characterization of this disease. To verify whether targeted field-of-view diffusion-weighted imaging (tFOV-DWI) is feasible to significantly improve the performance of traditional full field-of-view diffusion-weighted imaging (fFOV-DWI) in the early assessment of AKI. 14 rabbits with unilateral AKI were induced by injection of microspheres under the guidance of digital subtraction angiography (DSA). All rabbits underwent tFOV-DWI and fFOV-DWI immediately after the surgery. Artifacts, distortion and lesion identification were graded by two experienced radiologists, and the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured. Apparent diffusion coefficient (ADC) maps were then derived. Blood samples were collected pre- and post-surgery and serum creatinine weres measured. Renal specimen and biopsy were performed as the reference standard. Student t-test was used to ascertain statistical significance between the above parameters for tFOV-DWI and fFOV-DWI. The interobserver agreement and ADC measurements agreement were assessed. A higher percentage of renal lesions (17 out of 19) were detected in tFOV-DWI compared with fFOV-DWI (14 out of 19). Significant differences were observed in ADC value for both techniques between the lesion regions and normal tissues (p < 0.001). Histological findings were inversely correlated with ADC values of tFOV-DWI (r = −0.97, P < 0.001 for cortex; r = −0.98, P < 0.001 for medulla) and fFOV-DWI sequences (r = −0.95, P < 0.001 for cortex; r = −0.98, P < 0.001 for medulla). Those tFOV-DW images rated by the radiologists exhibit superior performance in terms of all assessed measures (P < 0.05), and interobserver agreement was excellent (ICC, 0.78 to 0.92). Besides, the ADC values derived from tFOV-DWI had a satisfactory agreement with those estimated by fFOV-DWI. The animal study demonstrates that the tFOV-DWI strategy provided visually better image quality and lesion depiction than conventional fFOV-DWI for early assessment of AKI.

https://ift.tt/2O5MGal

A Fully Automated Method for Accurate Measurement of Geometrical Distortion in Magnetic Resonance Imaging of a 3D-Lattice Phantom

Publication date: Available online 25 October 2018

Source: Magnetic Resonance Imaging

Author(s): S. Mangione, R. Acquaviva, G. Garbo

Abstract

This paper describes an automated method for extracting the apparent positions of fiducial points from 2D or 3D images of a phantom. We consider a 3D-lattice phantom for two main reasons: first, ease of manufacture and isotropy of its structure with respect to coordinate projections; second, a connected structure allowing to uniquely assess the adjacency relationship between fiducial points even if geometric distortions arising from main magnet inhomogeneity and gradient fields non-linearity is severe as observed in open-bore systems.

In order to validate our proposed method and compare different choices for the parameters of our phantom (i.e. number and distance between grids and thickness of its branches) we developed in-house a software for simulating 2D or 3D volume images of the phantom, using customizable MRI sequence parameters and Spherical Harmonic Coefficients for the fields.

We deem worthy of note that using simulated images is the only way to evaluate the estimated position error, since it allows to compare the estimates to their theoretical counterparts. Furthermore, the use of simulated images allows to evaluate the robustness of the method with respect to image quality in terms of Signal-to-Noise Ratios and geometric distortion, and allows to evaluate different phantom geometries without having to manufacture them. The proposed method can be easily extended to phantoms having an arbitrary overall shape, as long as it is a fully connected structure. Specifically, it is easy to design a phantom with fiducial points laying outside of the homogeneity sphere, so that indirect measurement of the fields becomes possible, for example by using the recent method proposed by Acquaviva et al.

To the best of our knowledge, the proposed method outperforms other state-of-the-art methods, with an average positioning offset of 0.052 mm (with a 0.99 quantile of 0.12 mm) when working on images featuring a differential Signal-to-Noise Ratio within Region-of-Interest (ROI) equal to 105 (20.2 dB) and a ROI-to-background SNR of 20 dB. Estimating the positions of 6859 fiducial points in a volume, our highest density case, was carried out in less than 30 minutes on a desktop personal computer.

https://ift.tt/2OSLLzq

High temperature/pressure MAS-NMR for the study of dynamic processes in mixed phase systems

Publication date: Available online 25 October 2018

Source: Magnetic Resonance Imaging

Author(s): Ali Chamas, Long Qi, Hardeep S. Mehta, Jesse A. Sears, Susannah L. Scott, Eric D. Walter, David W. Hoyt

Abstract

A new MAS-NMR rotor (the WHiMS rotor) has been developed which can reach pressures of 400 bar at 20 °C or 225 bar at 250 °C. These rotors are ideal for mixed phase systems such as a reaction using a solid catalyst with a liquid/supercritical solvent topped with high pressure gas in the head space. After solid and liquid portions of the sample are loaded, the rotor is capped with an o-ring equipped polymer bushing that snaps into a mating groove in the rotor. The bushings incorporate a check valve into the sealing mechanism which allows for pressurization without mechanical manipulation – they will allow gas to flow in but not out. This WHiMS rotor design has enabled experiments on a wide variety of biotic and abiotic mixed-phase systems. Geochemical systems have also been studied, for example, adsorption and confinement studies of supercritical methane/CO₂ in clays and other minerals which display pressure dependent ¹³C chemical shifts. Example data from other mixed-phase chemical and microbial systems are reported. These include monitoring metabolite conversion of extremophilic bacteria found in subsurface systems at elevated pressures and real-time operando reactions in catalysis systems - with liquid-quality resolution for ¹H and ¹³C NMR spectra.

https://ift.tt/2O7QiIU

EANM Springer Prizes awarded at EANM’18 in Düsseldorf

https://ift.tt/2qdtYnF

Correction to: A rare presentation of skull-base osteomyelitis with neurovascular sheath extension following external otitis resolved by PET/MRI

The figure in the original published version of this article was omitted.

https://ift.tt/2CIi1xF

The renaissance of functional 18 F-FDG PET brain activation imaging

https://ift.tt/2qaNdhB

U. Fischer, F. Baum, S. Luftner-Nagel. Breast Cancer: Diagnostic Imaging and Therapeutic Guidance

https://ift.tt/2CG8Uxu

Correlation of dose with toxicity and tumour response to 90 Y- and 177 Lu-PRRT provides the basis for optimization through individualized treatment planning

Abstract

Purpose

Peptide receptor radionuclide therapy (PRRT) with ⁹⁰Y-labelled and ¹⁷⁷Lu-labelled peptides is an effective strategy for the treatment of metastatic/nonresectable neuroendocrine tumours (NETs). Dosimetry provides important information useful for optimizing PRRT with individualized regimens to reduce toxicity and increase tumour responses. However, this strategy is not applied in routine clinical practice, despite the fact that several dosimetric studies have demonstrated significant dose–effect correlations for normal organ toxicity and tumour response that can better guide therapy planning. The present study reviews the key relationships and the radiobiological models available in the literature with the aim of providing evidence that optimization of PRRT is feasible through the implementation of dosimetry.

Methods

The MEDLINE database was searched combining specific keywords. Original studies published in the English language reporting dose–effect outcomes in patients treated with PRRT were chosen.

Results

Nine of 126 studies were selected from PubMed, and a further five were added manually, reporting on 590 patients. The studies were analysed and are discussed in terms of weak and strong elements of correlations.

Conclusion

Several studies provided evidence of clinical benefit from the implementation of dosimetry in PRRT, indicating the potential contribution of this approach to reducing severe toxicity and/or reducing undertreatment that commonly occurs. Prospective trials, possibly multicentre, with larger numbers of patients undergoing quantitative dosimetry and with standardized methodologies should be carried out to definitively provide robust predictive paradigms to establish effective tailored PRRT.

https://ift.tt/2qajJ3o

Lale Umutlu, Ken Herrmann (Eds.). PET/MR Imaging: Current and Emerging Applications

https://ift.tt/2CGBIWH

The influence of PSA flare in mCRPC patients treated with alpha-emitting radiopharmaceuticals

https://ift.tt/2qdBM8W

Correction to: a risk stratification model for nodal peripheral T-cell lymphomas based on the NCCN-IPI and posttreatment Deauville score

Unfortunately, the original version of this article contained several errors made during final step of article production. In the results section (fourth sentence) of the Abstract, the incomplete sentence,", 31.4% in high-risk group and 4.7% in treatment failure group.

https://ift.tt/2CEOSUg

Clinical translation of [ 18 F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer

Abstract

Background

Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [¹⁸F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have favourable dosimetry, safety, and biodistribution. We report the translation of [¹⁸F]ICMT-11 PET to measure chemotherapy-induced caspase-3/7 activation in breast and lung cancer patients receiving first-line therapy.

Results

Breast tumour SUV_max of [¹⁸F]ICMT-11 was low at baseline and unchanged following therapy. Measurement of M30/M60 cytokeratin-18 cleavage products showed that therapy was predominantly not apoptosis in nature. While increases in caspase-3 staining on breast histology were seen, post-treatment caspase-3 positivity values were only approximately 1%; this low level of caspase-3 could have limited sensitive detection by [¹⁸F]ICMT-11-PET. Fourteen out of 15 breast cancer patients responded to first–line chemotherapy (complete or partial response); one patient had stable disease. Four patients showed increases in regions of high tumour [¹⁸F]ICMT-11 intensity on voxel-wise analysis of tumour data (classed as PADS); response was not exclusive to patients with this phenotype. In patients with lung cancer, multi-parametric [¹⁸F]ICMT-11 PET and MRI (diffusion-weighted- and dynamic contrast enhanced-MRI) showed that PET changes were concordant with cell death in the absence of significant perfusion changes.

Conclusion

This study highlights the potential use of [¹⁸F]ICMT-11 PET as a promising candidate for non-invasive imaging of caspase3/7 activation, and the difficulties encountered in assessing early-treatment responses. We summarize that tumour response could occur in the absence of predominant chemotherapy-induced caspase-3/7 activation measured non-invasively across entire tumour lesions in patients with breast and lung cancer.

https://ift.tt/2EIVun2

Nuclear medicine RIP (radiation induced phobia); improving the image

https://ift.tt/2qdtXA7

Radiomics analysis of pre-treatment [ 18 F]FDG PET/CT for patients with metastatic colorectal cancer undergoing palliative systemic treatment

Abstract

Background

The aim of this study was to assess radiomics features on pre-treatment [¹⁸F]FDG positron emission tomography (PET) as potential biomarkers for response and survival in patients with metastatic colorectal cancer (mCRC).

Methods

Patients with mCRC underwent [¹⁸F]FDG PET/computed tomography (CT) prior to first- or third-line palliative systemic treatment. Tumour lesions were semiautomatically delineated and standard uptake value (SUV), metabolically active tumour volume (MATV), total lesion glycolysis (TLG), entropy, area under the curve of the cumulative SUV-volume histogram (AUC-CSH), compactness and sphericity were obtained.

Results

Lesions of 47 patients receiving third-line systemic treatment had higher SUV_max, SUV_peak, SUV_mean, MATV and TLG, and lower AUC-CSH, compactness and sphericity compared to 52 patients receiving first-line systemic treatment. Therefore, first- and third-line groups were evaluated separately. In the first-line group, anatomical changes on CT correlated negatively with TLG (ρ = 0.31) and MATV (ρ = 0.36), and positively with compactness (ρ = −0.27) and sphericity (ρ = −0.27). Patients without benefit had higher mean entropy (p = 0.021). Progression-free survival (PFS) and overall survival (OS) were worse with a decreased mean AUC [hazard ratio (HR) 0.86, HR 0.77] and increase in mean MATV (HR 1.15, HR 1.22), sum MATV (HR 1.14, HR 1.19), mean TLG (HR 1.16, HR 1.22) and sum TLG (HT1.12, HR1.18). In the third-line group, AUC-CSH correlated negatively with anatomical change (ρ = 0.21). PFS and OS were worse with an increased mean MATV (HR 1.27, HR 1.68), sum MATV (HR 1.35, HR 2.04), mean TLG (HR 1.29, HR 1.52) and sum TLG (HT 1.27, HR 1.80). SUV_max and SUV_peak negatively correlated with OS (HR 1.19, HR 1.21). Cluster analysis of the 10 radiomics features demonstrated no complementary value in identifying aggressively growing lesions or patients with impaired survival.

Conclusion

We demonstrated an association between improved clinical outcome and pre-treatment low tumour volume and heterogeneity as well as high sphericity on [¹⁸F]FDG PET. Future PET imaging research should include radiomics features that incorporate tumour volume and heterogeneity when correlating PET data with clinical outcome.

https://ift.tt/2CGBIGb

Prostate-specific antigen flare induced by 223 RaCl 2 in patients with metastatic castration-resistant prostate cancer

Abstract

Purpose

Prostate-specific antigen (PSA) flare is a well-known phenomenon in patients with prostate cancer, but its impact during radium-223 dichloride (²²³RaCl₂) therapy is still unclear. This radioisotope has shown to improve overall survival in metastatic castration-resistant prostate cancer (mCRPC). We sought to evaluate the impact of PSA flare on survival and its relation with metabolic parameters on ¹⁸F-labeled sodium fluoride PET/CT.

Methods

We conducted a retrospective study of 168 patients with mCRPC (median age 69; median PSA 29.7) receiving ²²³RaCl₂. Overall survival (OS) and progression-free survival (PFS), estimated by the Kaplan–Meier method and compared using a log-rank test, were evaluated for patient groups corresponding to different definitions of PSA flare. Metabolic ¹⁸F-fluoride PET/CT data were analyzed as well.

Results

Immediate PSA decline was observed in 49 patients (29.2%), whereas no PSA response was observed in 59 patients (35.1%). PSA flare (defined as rise after the first cycle followed by decrease below the baseline) was observed in 20 patients (11.9%) and PSA flare followed by a decrease from peak but not below baseline was observed in 40 (23.8%). The first flare subgroup had a median PFS and OS of 20.8 and 23.9 months, respectively. These outcomes were not significantly different from patients with immediate PSA decrease, but were significantly better than in patients with persistent PSA elevation (3.1 months for PFS and 11.5 months for OS, p < 0.001). Moreover, the PSA flare group showed an alkaline phosphatase (ALP) decrease significantly greater than non-responders (p = 0.003). Metabolic ¹⁸F-fluoride PET/CT data were available in 35 patients at baseline and during ²³³RaCl₂ therapy. The tumor burden reduction, expressed by ΔTLF₁₀ and ΔFTV_10, was more evident within PSA flare group below baseline than non-responders (p = 0.005 and 0.001, respectively).

Conclusions

This report suggests that a flare does not necessarily indicate lack of response to ²²³RaCl₂ therapy.

https://ift.tt/2qfbnaJ

30 Years of Neuroendocrinology: technological advances pave the way for molecular discovery

Journal of Neuroendocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2CH2sGH

Scholar : New articles have been published for Journal of Natural History, Volume 52, Issue 35-36

The online platform for Taylor & Francis Online content The following articles have been newly published in the issue Journal of Natural History, Volume 52, Issue 35-36 on Taylor & Francis Online: Articles New species of Nasutopedia from cloud forests of the Neotropical region (Hymenoptera: Apidae: Tapinotaspidini) Antonio J.C. Aguiar Pages: 2283-2300 | DOI: 10.1080/00222933.2018.1527962 Diet of tropical insectivorous birds in Lowland Malaysian rainforest Mohammad Saiful Mansor, Nurul Ashikin Abdullah, Muhammad Rasul Abdullah Halim, Shukor Md. Nor, Rosli Ramli Pages: 2301-2316 | DOI: 10.1080/00222933.2018.1534015 The issue is in progress. To view all articles already published in this issue, please visit: https://www.tandfonline.com/toc/tnah20/52/35-36 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Epidemiologic and genetic data suggest the presence of an endemic form of pemphigus foliaceus in Gran Canaria, Spain

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2CJasan

Commentary on Patients' Body Image Improves After Mohs Micrographic Surgery for Nonmelanoma Head and Neck Skin Cancer

No abstract available

https://ift.tt/2z2rBrN

Mohs Micrographic Surgery for the Treatment of Cutaneous Metastases in a Patient With Papillary Thyroid Carcinoma

No abstract available

https://ift.tt/2SfLbJY

Risk Factors for Basal Cell Carcinoma in Men Younger Than 40 Years: A Case–Control Study

BACKGROUND Basal cell carcinoma (BCC) is the most common malignancy in the United States and is more prevalent in older populations. OBJECTIVE The aim of this study was to investigate BCC risk factors in male patients younger than 40 years. MATERIALS AND METHODS A consecutive series of male patients with pathology-proven BCC and younger than 40 years at time of diagnosis were retrospectively identified along with matched controls. Phone interviews were conducted using a structured questionnaire, and differences between patients with and without BCC were investigated. RESULTS A total of 50 patients with BCC and 27 controls were included in this study. Compared with controls, patients with BCC worked outdoor jobs for longer lengths of time (43.2 vs 15.6 months; p = .04), were more likely to have a family history of skin cancer (66% vs 44%; p = .02), and were more likely to use sunscreen heavily after biopsy (p = .02). Patients with multiple BCCs (n = 20) were more likely to have a history of substantial recreational sun exposure (p = .01) than patients with solitary lesions (n = 30). CONCLUSION The authors conclude that outdoor sun exposure in patients with underlying genetic susceptibility is the most likely mechanism of BCC formation in young male patients.

https://ift.tt/2z7jSJ2

Reduction of Submental Fat Continues Beyond 28 Days After ATX-101 Treatment: Results From a Post hoc Analysis

No abstract available

https://ift.tt/2SkBsSU

Commentary on Risk Factors for Basal Cell Carcinoma in Men Younger Than 40 Years of Age

No abstract available

https://ift.tt/2z1CqKQ

Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma: A Diagnostic Conundrum

No abstract available

https://ift.tt/2SkBieg

Patients' Body Image Improves After Mohs Micrographic Surgery for Nonmelanoma Head and Neck Skin Cancer

BACKGROUND Most skin cancers occur on the head and neck, areas of the body that are significant to an individual's body image (BI) perception. Poor BI is a robust risk factor for depression and decreased quality of life. Thus, patients with nonmelanoma head and neck skin cancer (NMHNSC) may be more vulnerable to BI disturbance and the negative sequelae of poor BI. OBJECTIVE Describe the nature of BI concerns in patients diagnosed with NMHNSC and assess how BI changes with treatment. METHODS AND MATERIALS Patients undergoing Mohs micrographic surgery (MMS) for NMHNSC completed assessments of BI and well-being before (N = 239) and 6 months after (N = 80) treatment with MMS. Demographic and tumor data were gathered through retrospective chart review. RESULTS Body image improved significantly 6 months after MMS, and the magnitude of this change was large (η2 = 0.18). Repair length (length of final scar irrespective of repair type) >4 cm predicted poorer BI at 6-month follow-up. CONCLUSION Patients' BI improves after treatment with MMS for NMHNSC.

https://ift.tt/2z7jF8I

Commentary on a Retrospective Case-Matched Cost Comparison of Surgical Treatment of Melanoma and Nonmelanoma Skin Cancer in the Outpatient Versus Operating Room Setting

No abstract available

https://ift.tt/2SkBaeM

Pseudohalo Basal Cell Carcinoma

No abstract available

https://ift.tt/2SkB32Q

Melanoma Reporting Practices of United States Dermatologists

BACKGROUND Accuracy of US cancer statistics depends on physicians' knowledge of and adherence to reporting mandates. Significant knowledge and practice gaps have been documented in regards to melanoma reporting requirements. OBJECTIVE To determine whether the gaps in dermatologists' knowledge and practice of melanoma reporting persist. MATERIALS AND METHODS The authors performed a survey of US dermatologists attending a national conference. The proportion aware of the melanoma reporting mandate and the proportion who routinely report newly diagnosed cases were calculated. RESULTS Ninety-one percent (158/174) of those sampled completed the survey. Forty-nine percent correctly identified melanoma as being a disease of mandated reporting. Only 34% reported newly diagnosed cases to their state registry. Dermatologists seeing low melanoma volumes were less likely to routinely report newly diagnosed cases to registries than those seeing high volumes (22.9% vs 45.4%, p = .004). Those in practice for ≤10 years were less likely to be aware of the mandate than those in practice longer (32.6% vs 57.0%, p = .006). CONCLUSION Most dermatologists remain unaware of melanoma reporting requirements. Resultant underestimates of the true incidence of melanoma could have resource allocation implications. Interventions aimed at improving knowledge of the mandate should focus on younger clinicians and those with lower melanoma case volumes.

https://ift.tt/2z8C7xI

Hidradenitis Suppurativa–Like Condition Occurring After Microwave Sweat Gland Ablation

No abstract available

https://ift.tt/2Sl4RvW

Do Patterns of Reconstruction Choices After Mohs Surgery Vary by Specialty? A Pilot Study of Mohs Surgeons and Facial Plastic Surgeons

BACKGROUND Differences in approach to repair a specified defect after Mohs micrographic surgery (MMS) between specialties have not been previously examined. OBJECTIVE To assess the difference in frequency of which reconstruction repairs are selected after MMS, among Mohs surgeons and facial plastic surgeons (FPS), and evaluate whether the level of satisfaction with the final repair outcome differed between specialties. MATERIALS AND METHODS The study was approved by the Saint Louis University Institutional Review Board. A link to the survey was distributed to members of American College of Mohs Surgery (ACMS) and American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS), between January and May 2016. RESULTS The reconstructive procedure selected most often ("top choice") was not significantly different between Mohs surgeons and FPS for the majority of the images. There was no material difference in how dermatologists and FPS rate the aesthetic outcome of the 3 presented closure types, with the exception of one closure type—nose with graft. CONCLUSION Mohs surgeons were found to more likely cluster around a single preference for their reconstruction technique compared with FPS, in which a higher percentage of surgeons also selected other options.

https://ift.tt/2z4MrHf

Comprehensive Review of Tissue Adhesives

BACKGROUND Cyanoacrylates, also known as tissue adhesives or skin glues, are commonly used as sealants for lacerations and incisions and have found utility in excisional and cosmetic surgeries in both outpatient and operating room settings. OBJECTIVE To review the surgical literature on the utilities, advantages, disadvantages, and special uses of cyanoacrylates applicable to dermatology. MATERIALS AND METHODS PubMed was reviewed for relevant articles related to cyanoacrylates and their use in skin closures. Articles unrelated to cutaneous closures were excluded. RESULTS Tissue adhesives polymerize to a water resistant, pliable film after application to approximated wound edges and have antibacterial properties. Adhesives slowly slough off as the wound heals, typically after 5 days. Compared with 5-0 nonabsorbable suture, adhesives provide similar tensile strength and similar patient and surgeon satisfaction. Although slightly more expensive than sutures, tissue adhesives obviate the need for wound dressings and suture removal. They do not perform as well as sutures for wounds under higher tension or in the setting of moisture and inadequate hemostasis. CONCLUSION Cyanoacrylates serve as a safe and effective suture alternative in appropriate dermatologic surgeries and procedures.

https://ift.tt/2Shuazj

Sustained Benefit After Treatment of Acne Vulgaris Using Only a Novel Combination of Long-Pulsed and Q-Switched 1064-nm Nd: YAG Lasers

BACKGROUND Acne vulgaris remains a challenging disease to treat in many patients. Traditional therapies may have limited successes with potential side effects. Laser and light energy devices may offer a desirable alternative. OBJECTIVE To evaluate the effectiveness and safety in using a combination laser approach with both long-pulsed (LP) and Q-switched (QS) Nd:YAG lasers in the treatment of active acne. METHODS Twenty patients with moderate to severe inflammatory acne were treated with LP YAG laser followed immediately with QS YAG laser. Patients received at least 8 treatments. Follow-up evaluation occurred at a minimum of 12 months. Pre- and post-treatment photographs were graded by blinded physicians. All topical acne medications and oral antibiotics were discontinued throughout the therapy and follow-up period. RESULTS There was a 81% reduction in acne lesions, with 60% of patients having 90% or greater reduction. Overall appearance was graded at 84% improvement at follow-up. Follow-up occurred at a mean of 22.7 months after completion of therapy. Aside from transient erythema, there were no other adverse effects. CONCLUSION Active acne can be treated successfully with a combination of LP and QS YAG lasers with patients remaining off acne medications throughout laser therapy and the follow-up period.

https://ift.tt/2z4MrqJ

Conjunctival Concretions Found in Mohs Micrographic Surgery

No abstract available

https://ift.tt/2Sk6NoE

Efficacy and Safety of a Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial

BACKGROUND Previous studies have reported the benefits of low-level/light laser therapy (LLLT) for the promotion of hair regrowth. However, the effectiveness of LLLT for the treatment of androgenetic alopecia (AGA) is still a topic of debate. OBJECTIVE To investigate the efficacy and safety of LLLT on hair regrowth in patients with AGA. METHODS This 24-week, randomized, double-blind, self-comparison, sham device-controlled trial enrolled 100 patients with AGA. All participants were randomly assigned to receive the investigational LLLT on one side of the head and sham light treatment on the contralateral side, 3 times weekly for 30 minutes each, over a 24-week period. Global scalp photography, phototrichogram assessment, the investigator's global assessment (IGA) of hair regrowth, and the subject's assessment of the treatment satisfaction were used for evaluation. RESULTS After 24 weeks of treatment, the LLLT-treated scalp exhibited significantly greater hair coverage than the sham light-treated side (14.2% vs. 11.8%, p

https://ift.tt/2z6DSeK

Skin Necrosis on the Face and Scalp Due To Sclerotherapy

No abstract available

https://ift.tt/2SihEPP

Preliminary Experience With More Stable Polidocanol Foam in Sclerotherapy of Head and Neck Venous Malformations

BACKGROUND Foam sclerotherapy is an effective treatment strategy for venous malformations (VMs). Stability is one of the characteristics of sclerosant foams that determine the sclerosing power. OBJECTIVE To evaluate the clinical outcomes of sclerotherapy with prolonged half-life of hyaluronic acid (HA)–polidocanol (POL) foam for treating head and neck VMs. MATERIALS AND METHODS Seventy patients with head and neck VMs were enrolled between October 2013 and January 2015 in Qilu Hospital Shandong University. Sclerotherapy was performed with prolonged half-life POL foam by addition of 0.05% HA. All patients were followed up at 1, 3, and 6 months. Reviews on the site and size of the lesion, times and duration of treatments, therapeutic response, and complications were performed to evaluate the end result. RESULTS Sites of lesions included face, bucca, parotid region, neck, tongue, floor of mouth, lip, forehead, palate, and nose. An overall average of 2.5 treatments was required. Total response rate was 100%. "Resolution" was achieved in 21 cases (30%) and a significant response in 49 patients (70%). Immediate swelling was the most common complication. Epidermal extravasation was seen in 1 patient. Mucosal ulcer was observed in 1 patient. No generalized complications occurred. CONCLUSION The prolonged half-life of HA–POL foam sclerotherapy of VMs in the head and neck is safe and effective.

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Plaque-Type Syringoma Coexisting With Basal Cell Carcinoma

No abstract available

https://ift.tt/2SkLPG7

Epidermal Fluence Threshold Determination by Real-Time Melanin Measurements

BACKGROUND AND OBJECTIVE Epidermal preservation is essential during laser treatment for vascular, hair, and benign pigment dyschromias. Epidermal tolerance is determined by epidermal melanin content, fluence, pulse width, wavelength, skin cooling, and spot size. The authors' objective was to determine the maximum epidermal tolerance for the long-pulse alexandrite 755 nm and the long-pulse neodymium-doped yttrium aluminum garnet (Nd:YAG) 1064-nm lasers for varying epidermal melanin content. MATERIALS AND METHODS Skin melanin measurements were performed at the test sites with a melanin reader, and 0.5 to 1 second of refrigerated air precooled the skin. Then, alexandrite and Nd:YAG laser test spots of 5 to 18 mm were delivered in a series of ascending fluences using 5-, 20-, and 50-ms pulse widths. Skin response at 24 to 48 and 96 hours was scored from 0 to 15 varying from "no reaction" to "severe scabbing." RESULTS Alexandrite laser, mean threshold fluences increased by a factor of 1.2 increasing from 5 to 20 ms, and by a factor of 1.4 increasing from 5 to 50 ms, among subjects with a melanin index (MI) from 9 to 25 (Fitzpatrick skin phototype I-III). The Nd:YAG fluence to reach epidermal tolerance was 6X the fluence with the alexandrite laser for the same MI in subjects with MI 26 to 35. CONCLUSION Epidermal melanin measurements are quantitative and objective, therefore, improving treatment setting determination by decreasing the risk of overtreatment or undertreatment.

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