Microstructure-informed slow diffusion tractography in humans enhances visualisation of fibre pathways

Publication date: January 2018
Source:Magnetic Resonance Imaging, Volume 45
Author(s): Farida Grinberg, Ivan I. Maximov, Ezequiel Farrher, N. Jon Shah
Conventional fibre tractography methods based on diffusion tensor imaging exploit diffusion anisotropy and directionality in the range of low diffusion weightings (b-values). High b-value Biexponential Diffusion Tensor Analysis reported previously has demonstrated that fractional anisotropy of the slow diffusion component is essentially higher than that of conventional diffusion tensor imaging whereas popular compartment models associate this slow diffusion component with axonal water fraction. One of the primary aims of this study is to elucidate the feasibility and potential benefits of "microstructure-informed" whole-brain slow-diffusion fibre tracking (SDIFT) in humans. In vivo diffusion-weighted images in humans were acquired in the extended range of diffusion weightings≤6000smm⁻² at 3T. Fast and slow diffusion tensors were reconstructed using the bi-exponential tensor decomposition, and a detailed statistical analysis of the relevant whole-brain tensor metrics was performed. We visualised three-dimensional fibre tracts in in vivo human brains using deterministic streamlining via the major eigenvector of the slow diffusion tensor. In particular, we demonstrated that slow-diffusion fibre tracking provided considerably higher fibre counts of long association fibres and allowed one to reconstruct more short association fibres than conventional diffusion tensor imaging. SDIFT is suggested to be useful as a complimentary method capable to enhance reliability and visualisation of the evaluated fibre pathways. It is especially informative in precortical areas where the uncertainty of the mono-exponential tensor evaluation becomes too high due to decreased anisotropy of low b-value diffusion in these areas. Benefits can be expected in assessment of the residual axonal integrity in tissues affected by various pathological conditions, in surgical planning, and in evaluation of cortical connectivity, in particular, between Brodmann's areas.



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A new RF transmit coil for foot and ankle imaging at 7T MRI

Publication date: January 2018
Source:Magnetic Resonance Imaging, Volume 45
Author(s): Tales Santini, Junghwan Kim, Sossena Wood, Narayanan Krishnamurthy, Nadim Farhat, Carlos Maciel, Shailesh Raval, Tiejun Zhao, Tamer Ibrahim
A four-channel Tic-Tac-Toe (TTT) transmit RF coil was designed and constructed for foot and ankle imaging at 7T MRI. Numerical simulations using an in-house developed FDTD package and experimental analyses using a homogenous phantom show an excellent agreement in terms of B1⁺ field distribution and s-parameters. Simulations performed on an anatomically detailed human lower leg model demonstrated an B1⁺ field distribution with a coefficient of variation (CV) of 23.9%/15.6%/28.8% and average B1⁺ of 0.33μT/0.56μT/0.43μT for 1W input power (i.e., 0.25W per channel) in the ankle/calcaneus/mid foot respectively. In-vivo B1⁺ mapping shows an average B1⁺ of 0.29μT over the entire foot/ankle. This newly developed RF coil also presents acceptable levels of average SAR (0.07W/kg for 10g per 1W of input power) and peak SAR (0.34W/kg for 10g per 1W of input power) over the whole lower leg. Preliminary in-vivo images in the foot/ankle were acquired using the T2-DESS MRI sequence.



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Preface

Publication date: June 2017
Source:Best Practice & Research Clinical Endocrinology & Metabolism, Volume 31, Issue 3
Author(s): Furio Pacini




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Keyword index

Publication date: June 2017
Source:Best Practice & Research Clinical Endocrinology & Metabolism, Volume 31, Issue 3





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MTA1 expression in human cancers – Clinical and pharmacological significance

Publication date: November 2017
Source:Biomedicine & Pharmacotherapy, Volume 95
Author(s): Vijaya Lakshmi Malisetty, Vasudevarao Penugurti, Prashanth Panta, Suresh Kumar Chitta, Bramanandam Manavathi
Remarkably, majority of the cancer deaths are due to metastasis, not because of primary tumors. Metastasis is one of the important hallmarks of cancer. During metastasis invasion of primary tumor cells from the site of origin to a new organ occurs. Metastasis associated proteins (MTAs) are a small family of transcriptional coregulators that are closely associated with tumor metastasis. These proteins are integral components of nuclear remodeling and deacetylation complex (NuRD). By virtue of being integral components of NuRD, these proteins regulate the gene expression by altering the epigenetic changes such as acetylation and methylation on the target gene chromatin. Among the MTA proteins, MTA1 expression is very closely correlated with the aggressiveness of several cancers that includes breast, liver, colon, pancreas, prostate, blood, esophageal, gastro-intestinal etc. Considering its close association with aggressiveness in human cancers, MTA1 may be considered as a potential therapeutic target for cancer treatment. The recent developments in its crystal structure further strengthened the idea of developing small molecule inhibitors for MTA1. In this review, we discuss the recent trends on the diverse functions of MTA1 and its role in various cancers, with the focus to consider MTA1 as a 'druggable' target in the control of human cancers.



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Stem Cells and Other Emerging Agents as Innovative “Drugs” in Neurodegenerative Diseases: Benefits and Limitations

Rejuvenation Research , Vol. 0, No. 0.


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Venlafaxine exerts antidepressant effects possibly by activating MAPK–ERK1/2 and P13K–AKT pathways in the hippocampus

Publication date: 29 September 2017
Source:Behavioural Brain Research, Volume 335
Author(s): Peng Shen, Qingchuan Hu, Meixue Dong, Shunjie Bai, Zihong Liang, Zhi Chen, Pengfei Li, Zicheng Hu, Xiaogang Zhong, Dan Zhu, Haiyang Wang, Peng Xie
Serotonin noradrenaline reuptake inhibitors are effective antidepressant drugs, which include venlafaxine and duloxetine. Venlafaxine is commonly used in a clinical context, but the molecular biological mechanisms behind its effects have not been fully determined. Here, we explored the potential biological effects of venlafaxine on mouse hippocampus. Mice were randomly divided into two groups and injected daily with 0.9% NaCl solution or venlafaxine. A GC–MS-based metabolomic approach was used to identify possible metabolic differences between these groups, and the key proteins involved in the relevant pathways were validated by western blotting. In our experiments, 27 hippocampal metabolites that distinguished the venlafaxine group from the control group were identified. These differential metabolites were subjected to Ingenuity Pathway Analysis, which revealed that they were strongly related to two metabolic pathways (MAPK–ERK1/2 and P13K–AKT signaling pathways). Six key proteins, BDNF, p-c-Raf, p-MAPK, p-MEK, p-AKT, and CREB, were verified by western blotting and the results were consistent with the differential metabolites identified by GC–MS. This study sheds light on the biological mechanisms underlying the effects of venlafaxine.



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Intermittent hypoxia caused cognitive dysfunction relate to miRNAs dysregulation in hippocampus

Publication date: 29 September 2017
Source:Behavioural Brain Research, Volume 335
Author(s): Huabin Gao, Zhaoli Han, Shan Huang, Ruojing Bai, Xintong Ge, Fanglian Chen, Ping Lei
Intermittent hypoxia (IH) is a characteristic pathophysiological change of obstructive sleep apnea (OSA), a commonly diagnosed chronic sleep disorder. With the process of OSA, patients will suffer from the nervous system damage and appear to multiple cognitive dysfunction. The mechanism that how IH causes cognitive impairment is still unknown. Both control and experimental rats were placed in conditions absence and presence of intermittent hypoxia (IH) for 8h a day for a week, two weeks and four weeks, and then followed by behavioral assessments with Morris Water Maze (MWM) test. The results showed that the escape latency of the tested animals to IH significantly increased the escape latency on the last four training days in comparison to the control group. Consistent with this, the expressions of apoptosis/anti-apoptosis proteins were both changed in the hippocampus. Then we utilized the miRNA microarray assay to investigate the level of miRNA expression in rat hippocampus which suffered from intermittent hypoxia. It is noteworthy that the expressions of miR-26b and miR-207 were consistently dysregulated in all the experimental groups post IH. And we utilized qRT-PCR methods to verify the microarray results. Our results showed that microarray based analysis of microRNA expression in rat hippocampus after IH has shown that some microRNAs such as miR-26b and miR-207 could be involved in the OSA-induced cognitive impairments.



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Environmental enrichment protects spatial learning and hippocampal neurons from the long-lasting effects of protein malnutrition early in life

Publication date: 29 September 2017
Source:Behavioural Brain Research, Volume 335
Author(s): Roberto O. Soares, Everton Horiquini-Barbosa, Sebastião S. Almeida, João-José Lachat
As early protein malnutrition has a critically long-lasting impact on the hippocampal formation and its role in learning and memory, and environmental enrichment has demonstrated great success in ameliorating functional deficits, here we ask whether exposure to an enriched environment could be employed to prevent spatial memory impairment and neuroanatomical changes in the hippocampus of adult rats maintained on a protein deficient diet during brain development (P0-P35). To elucidate the protective effects of environmental enrichment, we used the Morris water task and neuroanatomical analysis to determine whether changes in spatial memory and number and size of CA1 neurons differed significantly among groups. Protein malnutrition and environmental enrichment during brain development had significant effects on the spatial memory and hippocampal anatomy of adult rats. Malnourished but non-enriched rats (MN) required more time to find the hidden platform than well-nourished but non-enriched rats (WN). Malnourished but enriched rats (ME) performed better than the MN and similarly to the WN rats. There was no difference between well-nourished but non-enriched and enriched rats (WE). Anatomically, fewer CA1 neurons were found in the hippocampus of MN rats than in those of WN rats. However, it was also observed that ME and WN rats retained a similar number of neurons. These results suggest that environmental enrichment during brain development alters cognitive task performance and hippocampal neuroanatomy in a manner that is neuroprotective against malnutrition-induced brain injury. These results could have significant implications for malnourished infants expected to be at risk of disturbed brain development.



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May the use of different background strains ‘strain’ the stress-related phenotype of GR+/− mice?

Publication date: 29 September 2017
Source:Behavioural Brain Research, Volume 335
Author(s): Miriam A. Vogt, Natascha Pfeiffer, Anne Marie Le Guisquet, Christiane Brandwein, Bruno Brizard, Peter Gass, Catherine Belzung, Sabine Chourbaji
Genetically altered mice are available on different background strains. While respective backcrosses are often performed for pragmatic reasons, e.g. references, comparability, or existing protocols, the interaction between the mutations per se and the background strain often remains a neglected factor.The heterozygous mutation of the glucocorticoid receptor gene (GR) represents a well-examined model for depressive-like behavior in mice. To address the question in how far a robust depressive-like phenotype on a distinct background strain may allow a generalized conclusion, we analyzed respective phenotypes in two commonly used inbred strains: i.) C57BL/6N and ii.) BALB/c.Beside the use of different genetic models, we also extended our approach by applying two alternative paradigms to induce a depressive-like phenotype. Our study therefore comprised the model of 'unpredictable chronic mild stress' (UCMS) for four weeks and 'learned helplessness' (LH), which were used to study the role of GR, a key player in the development of depression.In the course of the experiment two cohorts of male GR^+/− mice on either C57BL/6N or BALB/c background strain underwent a behavioral test battery to assess basal and depressive-like features.While both stress paradigms were functional in inducing depressive-like changes, the results were strictly strain-dependent. The genetic consequences became even more obvious under non-stress conditions with significant effects detected in BALB/c mice, which indicates a different basal stress predisposition due to differences in the genetic background.



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Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease

Publication date: 15 January 2018
Source:Behavioural Brain Research, Volume 336
Author(s): YuanBo Cui, ShanShan Ma, ChunYan Zhang, DongPeng Li, Bo Yang, PengJu Lv, Qu Xing, Tuanjie Huang, Greta Luyuan Yang, Wei Cao, FangXia Guan
Accumulating evidence suggests that oxidative stress induced by beta-amyloid (Aβ) is implicated in the pathlogical progression of Alzheimer's disease (AD). 3H-1,2-dithiole-3-thione (D3T), the simplest compound of the sulfur-containing dithiolethiones, has been proved to be a strongly active antioxidant factor by regulation of the nuclear factor E2-related factor 2 (Nrf2). Previous study reported that D3T confers protection to AD cell model in vitro, however, the neuroprotective effect of D3T in the AD mammalian model is unknown. In the present study, we aimed to evaluate the therapeutic potential of D3T in the Tg2576 AD mouse model and investigate the mechanisms underlying its beneficial effects. We showed that intraperitoneal administration of D3T significantly alleviated cognitive deficits in AD mice and dramatically decreased insoluble Aβ level and oxidative stress. Further mechanistic studies revealed that D3T significantly promoted hippocampal neurogenesis, and up-regulated levels of silent information regulator 1 (Sirt1), Nrf2 and heme oxygenase-1 (HO-1). Moreover, the positive effect of D3T on behavioral performance of AD mice was markedly attenuated by inhibition of the Sirt1/Nrf2 pathway by the antagonist EX527. In summary, our studies on a mouse AD model indicate that D3T could serve as a potential therapeutic agent for this devastating disease.



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Full title with Editorial board members

Publication date: 29 September 2017
Source:Behavioural Brain Research, Volume 335





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Corrigendum to “Ephrin-A5 regulates inter-male aggression in mice” [Behav. Brain Res. 286 (June) (2015) 300–307]

Publication date: 29 September 2017
Source:Behavioural Brain Research, Volume 335
Author(s): Michal Sheleg, Carrie L. Yochum, Jason R. Richardson, George C. Wagner, Renping Zhou




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Ensuring Consistent Results When Microneedling Perioral Rhytides.

No abstract available

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ATX-101 (Deoxycholic Acid Injection) Treatment in Men: Insights From Our Clinical Experience.

BACKGROUND: Excess submental fat (SMF), also called as a double chin, is an area of concern for men that can be addressed clinically. ATX-101 (deoxycholic acid injection; Kybella in the United States and Belkyra in Canada, Australia, and various European countries) is the first injectable approved for reduction of SMF. OBJECTIVE: To share the authors' clinical experience using ATX-101 in men with submental fullness and offer insights regarding how this treatment may be presented to men as an option to improve their submental profile. METHODS: Retrospective review of the authors' medical records for male patients treated with ATX-101. RESULTS: To allow for fewer ATX-101 treatments, it is recommended that a large surface area be treated at the first session. The positive changes and outcomes achieved with ATX-101 build confidence between the physician and patient, which often leads to male patients seeking other aesthetic treatments to improve their overall appearance. CONCLUSION: ATX-101 treatment is often an effective introduction to aesthetic medicine for men. (C) 2017 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Repair of a Full-Thickness Defect of the Right Upper Lip Extending Into Multiple Cosmetic Subunits.

No abstract available

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Novel Modality for Neck Rejuvenation: A Prospective Multicenter Trial of Percutaneous Radiofrequency Ablation of the Cervical Branch of the Facial Nerve.

BACKGROUND: Neck rejuvenation offers few modalities of treatments limited to either invasive plastic surgery or temporary neuromodulation using botulinum toxin. OBJECTIVE: To access the efficacy, longevity, and safety of percutaneous monopolar radiofrequency (RF) ablation of the cervical branch of the facial nerve innervating the platysma for neck rejuvenation. MATERIALS AND METHODS: This prospective, multicenter trial enrolled 19 adult patients with noticeable platysmal banding at 2 different centers. All patients underwent RF ablation on the cervical branch of the facial nerve. Response was assessed immediately after treatment and then at 1, 4, 12, and 24 weeks after the procedure using photography. Masked investigators compared baseline photography and follow-up intervals to evaluate the results. RESULTS: Seventeen of the 18 patients had improvement in the platysmal banding. One patient was disqualified after ablation. Long-term sequalae such as scarring, burns, ulceration, hypopigmentation, or hyperpigmentation were not reported. CONCLUSION: The results of this multicenter study support that RF ablation of the cervical branch of the facial nerve is a novel technique that results in improvement of platysmal banding. This technique is an emerging alternative, nonsurgical option for neck rejuvenation that is relatively safe, with little downtime for the patient. (C) 2017 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Association of Socioeconomic and Geographic Factors With Google Trends for Tanning and Sunscreen.

BACKGROUND: Internet search trends are used to track both infectious diseases and noncommunicable conditions. OBJECTIVE: The authors sought to characterize Google Trends search volume index (SVI) for the terms "sunscreen" and tanning ("tanning salon" and "tanning bed") in the United States from 2010 to 2015 and analyze association with educational attainment, average income, and percent white data by state. METHODS: SVI is search frequency data relative to total search volume. Analysis of variance, univariate, and multivariate analyses were performed to assess seasonal variations in SVI and the association of state-level SVI with state latitudes and census data. RESULTS: Hawaii had the highest SVI for sunscreen searches, whereas Alaska had the lowest. West Virginia had the highest SVI for tanning searches, whereas Hawaii had the lowest. There were significant differences between seasonal SVI for sunscreen and tanning searches (p

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Comparison of Pain Levels in Anterior Versus Cephalic Approach for Supraorbital/Supratrochlear Nerve Blocks.

No abstract available

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Chemical Peels: Indications and Special Considerations for the Male Patient.

BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men. RESULTS: Conditions treated successfully with chemical peels in men include acne vulgaris, acne scarring, rosacea, keratosis pilaris, melasma, actinic keratosis, photodamage, resurfacing of surgical reconstruction scars, and periorbital rejuvenation. Chemical peels are commonly combined with other nonsurgical cosmetic procedures to optimize results. Male patients may require a greater number of treatments or higher concentration of peeling agent due to increased sebaceous quality of skin and hair follicle density. CONCLUSION: Chemical peels are a cost-effective and reliable treatment for a variety of aesthetic and medical skin conditions. Given the increasing demand for noninvasive cosmetic procedures among men, dermatologists should have an understanding of chemical peel applications and techniques to address the concerns of male patients. (C) 2017 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Clinical Outcomes of Radiofrequency Ablation for Unilateral and Bilateral Varicose Veins.

BACKGROUND: Approximately 20% of varicose vein are bilateral. Patients prefer a simultaneous bilateral procedure instead of 2 separate unilateral procedures. There is currently little evidence comparing bilateral and unilateral varicose vein surgeries. OBJECTIVE: To report the clinical outcomes of unilateral and bilateral radiofrequency ablation (RFA) for varicose veins. MATERIALS AND METHODS: The authors retrospectively collected data on clinical outcomes of patients who underwent RFA. They investigated clinical, etiologic, anatomic, and pathophysiologic (CEAP) score, venous clinical severity score (VCSS), and quality of life (QoL) score. RESULTS: Radiofrequency ablation was performed in 546 limbs in 385 patients. Women comprised 60.4% of the patients. The mean age was 52.3 +/- 11.6 years (range, 19-84). The occlusion rate after 2 years was 94.5%. Clinical outcomes of CEAP score, VCSS, and QoL scores improved significantly from 2.15 +/- 0.45, 2.70 +/- 2.04, and 6.91 +/- 6.69 at baseline to 2.10 +/- 0.32, 0.63 +/- 0.04, and 3.38 +/- 4.74 at the study end, respectively. The preoperative and postoperative differences in CEAP score for unilateral and bilateral RFA were 0.02 +/- 0.21 and 0.13 +/- 0.49, respectively (p = .073). Those of VCSS for unilateral and bilateral RFA were 1.87 +/- 1.50 and 4.01 +/- 2.93, respectively (p

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A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face.

BACKGROUND: Seborrheic keratosis (SK) is a common benign skin tumor, yet no topical treatments are approved in the United States. OBJECTIVE: To evaluate the proprietary, stabilized, high-concentration hydrogen peroxide-based topical solution A-101 (32.5% and 40% concentrations) for treatment of facial SK lesions. MATERIALS AND METHODS: In this multicenter, double-blind, vehicle-controlled study, eligible subjects were randomly assigned to receive up to 2 treatments of A-101 40%, A-101 32.5%, or vehicle solution applied to a single facial SK lesion. The primary efficacy assessment was the Physician's Lesion Assessment (PLA), a validated 4-ordinal scale. RESULTS: The primary end point, the mean reduction in PLA grade from baseline to Day 106 was 1.7 for A-101 40%, 1.4 for A-101 32.5%, and 0.1 for vehicle (p

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Shave Versus Elliptical Biopsy for Melanoma Substantially Increases Re-excision Area and Length.

No abstract available

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A Randomized Evaluator-Blinded Trial Comparing Subsurface Monopolar Radiofrequency With Microfocused Ultrasound for Lifting and Tightening of the Neck.

BACKGROUND: Both subsurface monopolar radiofrequency (SMRF) and microfocused ultrasound with visualization (MFU-V) have demonstrated the ability to lift and tighten the neck. No head-to-head comparison study exists of these 2 technologies. OBJECTIVE: To compare the efficacy and safety of SMRF and MFU-V for the lifting and tightening of neck. MATERIALS AND METHODS: Twenty subjects aged from 18 to 65 with moderate neck skin laxity were randomized to receive either one treatment of SMRF or MFU-V. RESULTS: At Days 0, 30, 90, and 180, the mean (SD) investigator-assessed Neck Laxity Grade was 2.7 (0.67), 2.1 (1.1), 1.6 (1.2), and 0.86 (0.7), respectively, for patients treated with SMRF, and 2.8 (0.63), 2.4 (1.07), 1.5 (0.53), and 1.4 (0.7), respectively, for those treated with MFU-V. Both SMRF and MFU-V led to a significant decrease in the mean investigator-assessed Neck Laxity Grade by Day 90 and persistent to Day 180. Subject assessment of firmness, texture, and laxity also significantly improved by Day 90 and persistent to Day 180. Adverse events were mild and transient. CONCLUSION: There were no were statistically significant differences between SMRF and MFU-V in investigator-assessed and patient-assessed measures of neck laxity, patient satisfaction, and adverse events. Microfocused ultrasound with visualization was associated with more procedural pain. (C) 2017 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Multimodal Approach for Treating Horizontal Neck Wrinkles Using Intensity Focused Ultrasound, Cohesive Polydensified Matrix Hyaluronic Acid, and IncobotulinumtoxinA.

BACKGROUND: For the restoration of horizontal neck wrinkles, multimodal approaches using neuromodulators, intensity focused ultrasound (IFU), and fine line fillers are recommended. OBJECTIVE: To evaluate the efficacy and safety of a 1-day, multimodal approach for horizontal neck wrinkles. METHODS: Twelve female patients with horizontal neck wrinkles were treated with a combined treatment of IFU, cohesive polydensified matrix hyaluronic acid (CPMHA), and incobotulinumtoxinA. Therapeutic outcomes were assessed on Day 0 and 1, 2, 3, and 6 months thereafter. RESULTS: Horizontal neck wrinkles decreased significantly in length from a median at baseline of 269.75 mm (interquatile range [IQR], 235.35-302.94 mm) to 91.5 mm (IQR, 51.4-108.61 mm) at 1 month, 92.3 mm (IQR, 69.66-132.07 mm) at 2 months, 101.88 mm (IQR, 86-146.77 mm) at 3 months, and 109.48 mm (IQR, 85.06-148.17 mm) at 6 months after the combined treatment. The median global aesthetic improvement scale scores were 3.5 (IQR, 2-4) at 1 month, 3 (IQR, 3-3.5) at 2 months, 3 (IQR, 2-4) at 3 months, and 3 (IQR, 3-3) at 6 months. Post-treatment petechiae resolved completely within 7 days, and CPMHA-induced lumps disappeared within 1 month. CONCLUSION: The present data demonstrated that the multimodal, combined treatment used in the present study provides satisfactory and long-lasting therapeutic outcomes by targeting different pathogenetic factors of horizontal neck wrinkles. (C) 2017 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Commentary on The Nasal Tip Rotation Flap for Reconstruction of the Lateral Nasal Tip, Anterior Ala, and Soft Triangle.

No abstract available

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Repair of Defects of the Central Forehead With a Modified Banner Transposition Flap.

No abstract available

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Reactive Eccrine Syringofibroadenoma Associated With Basal Cell Carcinoma: A Histologic Mimicker of Fibroepithelioma of Pinkus.

No abstract available

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Safety and Efficacy of a Noninvasive 1,060-nm Diode Laser for Fat Reduction of the Flanks.

BACKGROUND: Preliminary reports indicate a hyperthermic diode laser treatment could be a safe and effective method for noninvasive fat reduction using the 1,060-nm wavelength. This wavelength penetrates the skin to heat subcutaneous adipocytes causing cellular disruption, leaving extracellular lipids, and cellular debris to be evacuated naturally by the body. OBJECTIVE: To evaluate the safety and effectiveness of this modality for noninvasive fat reduction of the flanks. MATERIALS AND METHODS: Forty-nine subjects received single laser treatment to 1 flank. Ultrasound images were taken at baseline, follow-up at 6 and 12 weeks after treatment. High-resolution photographs were taken at baseline and 12 weeks after treatment and then evaluated by independent reviewers. Adverse events recorded at all visits. Subjects completed a satisfaction questionnaire at the conclusion of the trial. RESULTS: Ultrasound images showed statistically significant (p

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Small-Particle Hyaluronic Acid Gel Treatment of Photoaged Hands.

BACKGROUND: Aging hands tend to lose subcutaneous volume resulting in prominence of the underlying vessels, tendons, and bone contributing to an aged appearance. Dermal fillers have been successfully used to improve the appearance of the aging dorsal hand. OBJECTIVE: The objective is to evaluate the safety and efficacy of a small-particle hyaluronic acid (SPHA) injectable gel for the treatment of photoaged volume loss of the hands. MATERIALS AND METHODS: This is an open-label, prospective, randomized, interventional, study. Twenty-five healthy female volunteer subjects aged 40 to 70 years with photoaged thinning of the hands received an injection of an SPHA gel to the dorsal aspect of 1 hand. Subjects were followed up for 6 months. The hands were evaluated at regular intervals according to a 5-point validated hand grading scale. RESULTS: The average hand grading scores demonstrated statistically significant improvement at all time points compared with baseline. Eighty-eight percent to 100% of subjects achieved improvement at 1 month after treatment, and 50% to 83% maintained at least 1 point improvement at 6 months. There were no adverse events reported. CONCLUSION: The investigated SPHA is a safe and effective method for improving the thinned and photoaged appearance of the hands. (C) 2017 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Clinical and Histological Evaluations of Enlarged Facial Skin Pores After Low Energy Level Treatments With Fractional Carbon Dioxide Laser in Korean Patients.

BACKGROUND: Enlarged facial pores can be an early manifestation of skin aging and they are a common aesthetic concern for Asians. However, studies of improving the appearance of enlarged pores have been limited. OBJECTIVE: The authors aimed to study the application of CO2 fractional laser treatment in patients with enlarged facial pores. METHODS: A total of 32 patients with dilated facial pores completed 3 consecutive sessions of low energy level treatments with a fractional CO2 laser at 4-week intervals. Image analysis was performed to calculate the number of enlarged pores before each treatment session and 12 weeks after the final treatment. RESULTS: After application of laser treatments, there was a significant decrease in the number of enlarged pores. The mean number of enlarged pores was decreased by 28.8% after the second session and by 54.5% at post-treatment evaluation. Post-treatment side effects were mild and transitory. Histological and immunohistochemical analyses demonstrated clear increases in the number of collagen fibers and the expression of transforming growth factor-[beta]1. CONCLUSION: The short-term results showed that treatment with low energy level CO2 fractional laser therapy could be a safe and effective option for patients with Fitzpatrick skin Types III and IV who are concerned with enlarged pores. (C) 2017 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Mutation-Based Therapy for Duchenne Muscular Dystrophy: Antisense Treatment Arrives in the Clinic.

Author: McNally, Elizabeth M. MD, PhD; Wyatt, Eugene J. PhD

Page: 979-981

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Physical Activity and Prognosis in the TOPCAT Trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist).

Author: Hegde, Sheila M. MD, MPH; Claggett, Brian PhD; Shah, Amil M. MD, MPH; Lewis, Eldrin F. MD, MPH; Anand, Inder MD, PhD; Shah, Sanjiv J. MD; Sweitzer, Nancy K. MD, PhD; Fang, James C. MD; Pitt, Bertram MD; Pfeffer, Marc A. MD, PhD; Solomon, Scott D. MD

Page: 982-992

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Physical Activity in Heart Failure With Preserved Ejection Fraction: Moving Toward a Newer Treatment Paradigm.

Author: Pandey, Ambarish MD; Berry, Jarett D. MD, MS

Page: 993-995

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Pericarditis as a Marker of Occult Cancer and a Prognostic Factor for Cancer Mortality.

Author: Sogaard, Kirstine Kobberoe PhD; Farkas, Dora Kormendine MSc; Ehrenstein, Vera DSc; Bhaskaran, Krishnan PhD; Botker, Hans Erik DMSc; Sorensen, Henrik Toft DMSc

Page: 996-1006

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Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis: A Report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort).

Author: Adriaenssens, Tom MD, PhD *; Joner, Michael MD *; Godschalk, Thea C. MSc; Malik, Nikesh MD; Alfonso, Fernando MD, PhD; Xhepa, Erion MD; De Cock, Dries MD; Komukai, Kenichi MD; Tada, Tomohisa MD; Cuesta, Javier MD; Sirbu, Vasile MD; Feldman, Laurent J. MD, PhD; Neumann, Franz-Josef MD; Goodall, Alison H. PhD; Heestermans, Ton MD; Buysschaert, Ian MD, PhD; Hlinomaz, Ota MD; Belmans, Ann MSc; Desmet, Walter MD; ten Berg, Jurrien M. MD, PhD; Gershlick, Anthony H. MD; Massberg, Steffen MD; Kastrati, Adnan MD; Guagliumi, Giulio MD +; Byrne, Robert A. MB, BCh, PhD +; on behalf of the Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators

Page: 1007-1021

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A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective.

Author: Yu, Baoqi PhD *; Kiechl, Stefan MD *; Qi, Dan MB; Wang, Xiaocong PhD; Song, Yanting MB; Weger, Siegfried MD; Mayr, Agnes MD; Le Bras, Alexandra PhD; Karamariti, Eirini PhD; Zhang, Zhongyi MSc; Barco Barrantes, Ivan del PhD; Niehrs, Christof PhD; Schett, Georg MD; Hu, Yanhua MD; Wang, Wen PhD; Willeit, Johann MD; Qu, Aijuan PhD; Xu, Qingbo MD, PhD

Page: 1022-1036

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Germline Loss-of-Function Mutations in EPHB4 Cause a Second Form of Capillary Malformation-Arteriovenous Malformation (CM-AVM2) Deregulating RAS-MAPK Signaling.

Author: Amyere, Mustapha PhD *; Revencu, Nicole MD, PhD *; Helaers, Raphael PhD; Pairet, Eleonore BSC; Baselga, Eulalia MD; Cordisco, Maria MD; Chung, Wendy MD, PhD; Dubois, Josee MD; Lacour, Jean-Philippe MD; Martorell, Loreto MD; Mazereeuw-Hautier, Juliette MD, PhD; Pyeritz, Reed E. MD, PhD; Amor, David J. MD; Bisdorff, Annouk MD; Blei, Francine MD; Bombei, Hannah MSc; Dompmartin, Anne MD, PhD; Brooks, David MD; Dupont, Juliette MD; Gonzalez-Ensenat, Maria Antonia MD; Frieden, Ilona MD; Gerard, Marion MD; Kvarnung, Malin MD; Hanson-Kahn, Andrea Kwan MSc; Hudgins, Louanne MD; Leaute-Labreze, Christine MD; McCuaig, Catherine MD; Metry, Denise MD; Parent, Philippe MD; Paul, Carle MD, PhD; Petit, Florence MD; Phan, Alice MD; Quere, Isabelle MD; Salhi, Aicha MD; Turner, Anne MD; Vabres, Pierre MD; Vicente, Asuncion MD; Wargon, Orli MD; Watanabe, Shoji MD, PhD; Weibel, Lisa MD; Wilson, Ashley MSc; Willing, Marcia MD; Mulliken, John B. MD; Boon, Laurence M. MD, PhD; Vikkula, Miikka MD, PhD

Page: 1037-1048

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Conduction Disturbances After Transcatheter Aortic Valve Replacement: Current Status and Future Perspectives.

Author: Auffret, Vincent MD, MSc; Puri, Rishi MBBS, PhD; Urena, Marina MD, PhD; Chamandi, Chekrallah MD; Rodriguez-Gabella, Tania MD; Philippon, Francois MD; Rodes-Cabau, Josep MD

Page: 1049-1069

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Irregular Narrow Complex Tachycardia in a 29-Year-Old Woman.

Author: Naksuk, Niyada MD; Schleifer, J. William MD; Deshmukh, Abhishek J. MBBS; Madhavan, Malini MBBS

Page: 1070-1072

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Origin of Cardiac Troponin T Elevations in Chronic Kidney Disease.

Author: van der Linden, Noreen MD; Cornelis, Tom PhD; Kimenai, Dorien M. MSc; Klinkenberg, Lieke J.J. PhD; Hilderink, Judith M. MD; Luck, Sarah MSc; Litjens, Elisabeth J. R. MD; Peeters, Frederique E.C.M. MD; Streng, Alexander S. PhD; Breidthardt, Tobias MD; van Loon, Luc J.C. PhD; Bekers, Otto PhD; Kooman, Jeroen P. PhD; Westermark, Pal O. PhD; Mueller, Christian MD; Meex, Steven J.R. PhD

Page: 1073-1075

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Letter by Ferrero et al Regarding Article, "Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study".

Author: Ferrero, Paolo MD; D'Elia, Emilia MD, PhD; Ciuffreda, Matteo MD

Page: 1076-1077

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Response by Kempny et al to Letter Regarding Article, "Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study".

Author: Kempny, Aleksander MD; Sorensen Hjortshoj, Cristel; Li, Wei MD, PhD; Schophuus Jensen, Annette PhD; Sondergaard, Lars MD, DMSc; Diller, Gerhard-Paul MD, PhD, MSc; Dimopoulos, Konstantinos MD, PhD, MSc; Wort, Stephen J. MA, MBBS, PhD; Gatzoulis, Michael A. MD, PhD

Page: 1078-1079

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Letter by Ciliberti and Capucci Regarding Article, "Medical Therapy for Secondary Prevention and Long-Term Outcome in Patients With Myocardial Infarction With Nonobstructive Coronary Artery Disease".

Author: Ciliberti, Giuseppe MD; Capucci, Alessandro MD

Page: 1080-1081

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Response by Lindahl et al to Letter Regarding Article, "Medical Therapy for Secondary Prevention and Long-Term Outcome in Patients With Myocardial Infarction With Nonobstructive Coronary Artery Disease".

Author: Lindahl, Bertil MD, PhD; Baron, Tomasz MD, PhD; Erlinge, David MD, PhD; Hadziosmanovic, Nermin MSc; Nordenskjold, Anna MD, PhD; Gard, Anton MD; Jernberg, Tomas MD, PhD

Page: 1082-1083

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Correction to: When Lightning Strikes: Fulminant Myocarditis in the Realm of Inflammatory Cardiomyopathies.

Author:

Page: e198

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Correction to: Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification.

Author:

Page: e199

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Effects of Early Integrated Palliative Care on Caregivers of Patients with Lung and Gastrointestinal Cancer: A Randomized Clinical Trial

AbstractBackground.The family and friends (caregivers) of patients with advanced cancer often experience tremendous distress. Although early integrated palliative care (PC) has been shown to improve patient‐reported quality of life (QOL) and mood, its effects on caregivers' outcomes is currently unknown.Materials and Methods.We conducted a randomized trial of early PC integrated with oncology care versus oncology care alone for patients who were newly diagnosed with incurable lung and noncolorectal gastrointestinal cancers and their caregivers. The early PC intervention focused on addressing the needs of both patients and their caregivers. Eligible caregivers were family or friends who would likely accompany patients to clinic visits. The intervention entailed at least monthly patient visits with PC from the time of diagnosis. Caregivers were encouraged, but not required, to attend the palliative care visits. We used the Hospital Anxiety and Depression Scale (HADS) and Medical Health Outcomes Survey Short‐Form to assess caregiver mood and QOL.Results.Two hundred seventy‐five caregivers (intervention n = 137; control n = 138) of the 350 patients participated. The intervention led to improvement in caregivers' total distress (HADS‐total adjusted mean difference = −1.45, 95% confidence interval [CI] −2.76 to −0.15, p = .029), depression subscale (HADS‐depression adjusted mean difference = −0.71, 95% CI −1.38 to −0.05, p = .036), but not anxiety subscale or QOL at week 12. There were no differences in caregivers' outcomes at week 24. A terminal decline analysis showed significant intervention effects on caregivers' total distress (HADS‐total), with effects on both the anxiety and depression subscales at 3 and 6 months before patient death.Conclusion.Early involvement of PC for patients with newly diagnosed lung and gastrointestinal cancers leads to improvement in caregivers' psychological symptoms. This work demonstrates that the benefits of early, integrated PC models in oncology care extend beyond patient outcomes and positively impact the experience of caregivers.Implications for Practice.Early involvement of palliative care for patients with newly diagnosed lung and gastrointestinal cancers leads to improvement in caregivers' psychological symptoms. The findings of this trial demonstrate that the benefits of the early, integrated palliative care model in oncology care extend beyond patient outcomes and positively impact the experience of caregivers. These findings contribute novel data to the growing evidence base supporting the benefits of integrating palliative care earlier in the course of disease for patients with advanced cancer and their caregivers.

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In Reply

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The Issue of Tissue in Molecular Stratification

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Propensity Score Analysis of Regorafenib Versus Trifluridine/Tipiracil in Patients with Metastatic Colorectal Cancer Refractory to Standard Chemotherapy (REGOTAS): A Japanese Society for Cancer of the Colon and Rectum Multicenter Observational Study

AbstractBackground.This study compared the efficacy of regorafenib and trifluridine/tipiracil (TFTD) in patients with metastatic colorectal cancer (mCRC) who are refractory to standard chemotherapy, because despite their clinical approval, it still remains unclear which of these two drugs should be used as initial treatment.Materials and Methods.The clinical data of patients with mCRC who were treated with regorafenib or TFTD and those of drug‐naive patients, between June 2014 and September 2015, were retrospectively collected from 24 institutions in Japan. Overall survival (OS) was evaluated using the Cox's proportional hazard models based on propensity score adjustment for baseline characteristics.Results.A total of 550 patients (223 patients in the regorafenib group and 327 patients in the TFTD group) met all criteria. The median OS was 7.9 months (95% confidence interval [CI], 6.8–9.2) in the regorafenib group and 7.4 months (95% CI, 6.6–8.3) in the TFTD group. The propensity score adjusted analysis showed that OS was similar between the two groups (adjusted hazard ratio [HR], 0.96; 95% CI, 0.78–1.18). In the subgroup analysis, a significant interaction with age was observed. Regorafenib showed favorable survival in patients aged <65 years (HR, 1.29; 95% CI, 0.98–1.69), whereas TFTD was favored in patients aged ≥65 years (HR, 0.78; 95% CI, 0.59–1.03).Conclusion.No significant difference in OS between regorafenib and TFTD was observed in patients with mCRC. Although the choice of the drug by age might affect survival, a clearly predictive biomarker to distinguish the two drugs should be identified in further studies.Implications for Practice.Previous studies of patients with metastatic colorectal cancer refractory to standard chemotherapy had demonstrated that both regorafenib and trifluridine/tipiracil could result in increased overall survival compared with placebo, but there is no head‐to‐head trials. This large, multicenter, observational study retrospectively compared the efficacy of regorafenib and trifluridine/tipiracil in 550 patients with metastatic colorectal cancer refractory to standard chemotherapy who had access to both drugs. Although no difference in overall survival was found between the two drugs in adjusted analysis using propensity score, regorafenib showed favorable survival in patients aged <65 years, whereas trifluridine/tipiracil was favored in patients aged ≥65 years in the subgroup analysis.

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Scholar : Ειδοποίηση Μελετητή - [ CPAP ]

Ειδοποίηση Μελετητή:[ CPAP ]

Prognosis in patients with obstructive sleep apnea with special reference to comorbidities and treatment of positive airway pressure

T Kawada - Sleep Medicine, 2017

... conducted a retrospective cohort study to evaluate the effects of continuous positive airway
pressure (CPAP) in patients with obstructive sleep apnea (OSA) on all-cause mortality by
considering major comorbidities [1]. Hazard ratios of male, age, lower education, diabetes ...

Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants

RM Patel, K Zimmerman, DP Carlton, R Clark… - The Journal of Pediatrics, 2017

... To test the hypothesis that early caffeine treatment on the day of birth, compared with later
treatment in very low birth weight (VLBW, <1500 g) infants receiving continuous positive airway
pressure (CPAP) therapy, is associated with a decreased risk of CPAP failure in the first ...

Effect of a patient engagement tool on positive airway pressure adherence: analysis of a German healthcare provider database

H Woehrle, M Arzt, A Graml, I Fietze, P Young… - Sleep Medicine, 2017

... The pattern of compliance during the first week of continuous positive airway pressure (CPAP)
therapy is predictive of longer-term device usage [1], and improving patient experiences with
PAP therapy is likely to also influence their willingness to engage with therapy over time. ...

Survey of neonatal nurses' practices and beliefs in relation to skin health

HL Liversedge, DL Bader, L Schoonhoven, PR Worsley - Journal of Neonatal Nursing, 2017

... 2. Local Neonatal Unit (LNU): for babies needing short-term intensive care with
respiratory support, including continuous positive airway pressure (CPAP). 3. Neonatal
Intensive Care Unit (NICU): for babies who are born at <28 ...

[HTML] Estradiol Regulates Txnip and Prevents Intermittent Hypoxia-Induced Vascular Injury

XF Lan, XJ Zhang, YN Lin, Q Wang, HJ Xu, LN Zhou… - Scientific Reports, 2017

... 2% of women 1 . Chronic intermittent hypoxia (IH) caused by repetitive upper airway collapse
contributes to systemic complications including cardiovascular diseases (CVD) 2 , 3 . As the
first-choice treatment of OSA, continuous positive airway pressure (CPAP) decreases the ...

Predictive factors for the outcome of high flow nasal cannula therapy in a pediatric intensive care unit: Is the SpO 2/FiO 2 ratio useful?

FK Can, AB Anıl, M Anıl, N Zengin, F Durak… - Journal of Critical Care, 2017

... Recently, studies have suggested that HFNC therapy decreases the work of breathing, improves
oxygenation, and provides a continuous positive airway pressure (CPAP) effect, including in
a range of diagnoses for respiratory distress in PICU and emergency care settings [6]; [7 ...

Circulating C3 and glucose metabolism abnormalities in patients with OSAHS

X Lu, X Wang, T Xu, Y Feng, Y Wang, Z Cai, B Cao, T Li - Sleep and Breathing, 2017

... A randomized and double-blind crossover study [10] has suggested that patients
with severe OSAHS can benefit metabolic effects from continuous positive airway
pressure (CPAP), a first-line treatment for OSAHS. However ...

High-Flow-Sauerstofftherapie in der Intensivmedizin

M Simon, J Grensemann, S Kluge - Intensivmedizin up2date, 2017

... Lungenerkrankung). CPAP: Continuous positive Airway Pressure (kontinuierlicher
positiver Atemwegsdruck). CRP: C-reaktives Protein. F i O 2 : inspiratorische
Sauerstofffraktion. ... Die Datenlage zur Anwendung von CPAP bzw. NIV ...

Welche Atemunterstützung bei akuter viraler Bronchiolitis im Säuglingsalter?

S trotz Koffeingabe - Journal Club AINS, 2017

... Bei immerhin ca. 10% der Kinder wird dabei eine Atemunterstützung erforderlich, in erster Linie
kommt eine nasale CPAP-Atmung (continu- ous positive airway pressure) zur An- wendung.
Ist die High-Flow-Sauer- stoffgabe über eine Nasenbrille eben- so wirksam? ...

[PDF] Oral ibuprofen in full-term neonate's patent ductus arteriosus closure: Discerning the role of prostaglandin, vascular endothelial growth factor, and immature platelet …

NPVK Yantie, MM Djer, FD Suyatna, IS Timan, ST Putra… - Current Pediatric Research, 2017

... 92.6 (3.3) 91.9 (1.6) 93 (3) Supportive therapy, nasal CPAP, n ... Note: SpO2: Peripherally Oxygen
Saturation; CPAP: Continues Positive Airway Pressure; LA/Ao: Left Atrium/Aorta Ratio; PDA: Patent
Ductus Arteriosus; LVEF: Left Ventricle Ejection Fraction; SD: Standard Deviation ...

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Scholar : Ειδοποίηση Μελετητή - [ ΠΑΡΕΣ

Ειδοποίηση Μελετητή:[ ΠΑΡΕΣΗ BELL ]

[PDF] BELL'S PALSY AMONG INFANTS-OUR EXPERIENCES IN A TERTIARY CARE HOSPITAL OF EASTERN INDIA

SK SWAIN, IC BEHERA, MC SAHU - Asian J Pharm Clin Res, 2017

... Worster A, Keim SM, Sahsi R, Pancioli AM. Best evidence in emergency medicine (BEEM) group.
Do either corticosteroids or antiviral agents reduce the risk of long-term facial paresis in patients
with new-onset Bell's palsy? J Emerg Med 2010;38:518-23. 11. ...

Kinematic Outcome Measures using Target-Reaching Arm Movement in Stroke

Q Yang, Y Yang, J Luo, L Li, T Yan, R Song - Annals of Biomedical Engineering, 2017

... the efficiency of movement, and longer MT may attribute to larger task complexity or the emphasis
on feedback somatosensation caused by paresis. ... 3. It is obvious that movement of the control
subject was characterized by a bell-shaped velocity profile, while the patient's ...

[PDF] Ανοσοφαινότυπος Τ λεμφοκυττάρων σε πειραματικό μοντέλο πολλαπλής σκλήρυνσης

Η Ζιώγας - 2017

... Σε συγκριτική μελέτη του 2010 μεταξύ ασθενών με ΠΣ και ομάδας υγιών ατóμων βρέθηκε óτι οι
ασθενείς με ΠΣ ήταν σημαντικά πιθανóτερο να έχουν ραγοειδίτιδα, φλεγμονώδη νóσο του εντέρου,
παράλυση του Bell, σύνδρομο Guillain-Barre και τη δερματική νóσο Bulous ...

[DOC] PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

M AJWANI

... TRIAL. Brief resume of the intended work:-. 6.1 Need for the study: Bell's palsy and
idiopathic facial palsy are considered to be synonymous and specify an acute, mono
synaptic, unilateral peripheral paresis of unknown etiology. 1. ...

Prepartum daylight exposure increases serum calcium concentrations in dairy cows at the onset of lactation1

R Özçelik, RM Bruckmaier, LE Hernández-Castellano - 2017

... any symp- toms of illness apart from those expected in this study (those related to HC such as
recumbency, paresis, and fine ... to regulate calcium homeostasis, but they also need to regulate
the rapid increase in energy demand to support milk production (Bell, 1995; DeGaris ...

Risk factor analysis of kyphotic malalignment after cervical intramedullary tumor resection in adults

S Nori, A Iwanami, A Yasuda, N Nagoshi, N Fujita… - Journal of Neurosurgery: …, 2017

... However, we think that paresis, dysphagia, and unbearable pain due to the developing cervical
malalignment following tumorectomy would be indications for ... J Neurol Neurosurg Psychiatry
39:290–296, 1976 Crossref, Medline. 4. Bell DF , Walker JL , O'Connor G , Tibshirani R ...

Primary HIV Infection: Clinical Presentation, Testing, and Treatment

A Henn, C Flateau, S Gallien - Current Infectious Disease Reports, 2017

... cases [12]. Two clinical points deserve special attention. First, neurological
involvement, including aseptic meningitis, encephalitis, and facial nerve paresis,
is reported in 14 to 25% of patients with ARS [9, 12]. Clinicians should ...

Applications of Electroencephalography in Status Epilepticus

Y Hu, S Li - Refractory Status Epilepticus, 2017

Skip to main content Skip to sections This service is more advanced with
JavaScript available, learn more at http://ift.tt/2lzIB0l. ...

Epilepsy, Status Epilepticus, and Refractory Status Epilepticus

Y Chen, S Li - Refractory Status Epilepticus, 2017

... 1.3 Focal motor seizures. Recurrent focal motor seizures. Partial SE. Adversive status. Oculoclonic
status. Ictal paresis (focal inhibitory SE). 1.4 Tonic SE. 1.5 Hyper-motor SE. II. Without obvious
motor component, namely, NCSE. 2.1 Coma, including subtle SE. 2.2 Without coma. ...

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