Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2oflPhx
Δευτέρα 27 Αυγούστου 2018
Early‐onset neutropenia after rituximab therapy for bullous pemphigoid
Scarring alopecia with follicular papules in a father and his daughter
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2Nokyjk
Concentrations and health risks of heavy metals in soils and crops around the Pingle manganese (Mn) mine area in Guangxi Province, China
Abstract
Heavy metal concentrations in agricultural fields and their ecological risks are a source of extensive concern worldwide. A field survey was conducted to investigate the present situation and health risks of heavy metals (Mn, Pb, Zn, Cu, and Cd) and crops (corn, green soybean, sweet potato, persimmon, cassava, and Chinese chestnut) around the Pingle manganese (Mn) mine site in Guangxi Province, China, which was abandoned 20 years ago. The results showed that the ranges of Mn, Pb, Zn, Cu, and Cd were 2706.54–6760.16, 229.37–275.84, 160.39–215.48, 58.11–75.30, and 5.78–6.98 mg kg−1, respectively, which were approximately 15.38–38.41, 11.76–14.15, 2.12–2.85, 2.09–2.71, and 21.64–28.75 times greater than their respective background values. Most of these concentrations exceeded the national standard for soil quality (grade 2) developed by the Ministry of Environmental Protection of China (1995). Contamination assessments based on the single contamination index (Pi), Nemerow multi-factor index (Pcom), and potential ecological risk index (RI) showed that the sampled soils were severely polluted with these heavy metals, especially Pb and Cd. Similarly, the crops were enriched with Pb and Cd, with concentrations of 10.22–41.78 and 2.33–5.37 mg kg−1, respectively, which were much higher than the threshold values of the national food standards. Contamination assessments with Pi and Pcom also showed that the crops were severely polluted with Pb and Cd. The bioaccumulation factor values for Cd were highest among the heavy metals, with an average mean of 0.66 in these six crops, demonstrating that Cd readily accumulates in these crops. An assessment showed that the health risk for adults living in the mining-impacted areas was significant. Our study strongly recommends that heavy metal contamination in agricultural soils and crops grown around the Pingle Mn mining-affected areas should be treated to mitigate the health risks.
https://ift.tt/2PGKlEV
Statement from NCI Director Dr. Norman E. Sharpless on the Death of Senator John McCain
Senator John McCain, a long-time supporter of cancer research, passed away on August 25.
https://ift.tt/2NpiGqx
The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study
Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0669-9309
Background Both vitamin D preparations and high-dose statin therapy were found to reduce thyroid antibody titers. Objective The purpose of this study was to assess whether vitamin D status determines the effect of statin therapy on thyroid autoimmunity. Methods The study population consisted of 39 euthyroid women with Hashimoto's thyroiditis and moderate or moderately high cardiovascular risk divided into two groups: women with vitamin D deficiency or insufficiency (group A; n=19) and women with normal vitamin D status (group B, n=20). All patients received atorvastatin therapy (20–40 mg daily) for the following 6 months. Plasma lipids, circulating levels of thyrotropin, free thyroid hormones, prolactin and 25-hydroxyvitamin D, titers of thyroid peroxidase and thyroglobulin antibodies, as well as Jostel's, the SPINA-GT and the SPINA-GD indices were assessed at the beginning and at the end of the study. Results The study completed all women. At baseline, with the exception of 25-hydroxyvitamin D, there were no significant differences between both study groups in plasma lipids, circulating hormone levels and titers of thyroid peroxidase and thyroglobulin antibodies. Despite improving plasma lipids in both study groups, atorvastatin reduced thyroid antibody titers only in women with normal vitamin D status. Moreover, in this group of patients, atorvastatin increased the SPINA-GT index. Circulating levels of the measured hormones, Jostel's thyrotropin index and the SPINA-GD index remained at a similar level throughout the study. Conclusions The results of the study suggest that the effect of atorvastatin therapy on thyroid autoimmunity depends on vitamin D status.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Elevation in Circulating Soluble CD40 Ligand Concentrations in Type 2 Diabetic Retinopathy and Association with its Severity
Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0647-6860
Background To investigate the relationship between changes in circulating soluble CD40 ligand (sCD40L) levels and the presence and severity of type 2 diabetic retinopathy (DR). Subjects and methods sCD40L plasma concentrations were measured in 205 type 2 diabetes (T2DM) patients without DR (DWR; n=50) and with DR (n=155), the latter subdivided into non-proliferative diabetic retinopathy [NPDR; n=98 (63.2%)], or proliferative retinopathy [PDR; n=57 (36.8%)] patients. Results Receiver operating characteristic analysis provided good discriminatory power for sCD40L as predictor of DR presence, with high sensitivity and specificity. Categorizing DWR and DR patients into sCD40L quartiles, based on sCD40L concentrations in T2DM without DR, demonstrated statistically significant gradual increase in DR risk with increasing sCD40L levels. sCD40L levels were significantly higher in DR compared to DWR patients. Plasma sCD40L levels differed significantly according to DR severity, and correlated with diabetes duration, dyslipedimea, nephropathy, and presence of DR, but not with gender, age, SBP, DBP, FPG, HbA1c, T2DM medications. Linear regression analysis confirmed the association of increased sCD40L levels with DR, independent of others parameters; mean plasma sCD40L levels differing significantly according to DR severity. Conclusion Plasma sCD40L levels were positively associated with DR. The significant finding here is that sCD40L levels can be predictors of DR severity.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2P9kBQo
Statins and Colorectal Cancer – A Systematic Review
Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0668-5692
Objectives Statins act by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase and are an important drug class in the treatment of lipid disorders. They lower cholesterol levels and modulate cardiovascular disease risk in both primary and secondary prevention. In addition, some studies have shown that statins may have an effect on colorectal cancer development and treatment. Our objective is to summarize published studies on the effect of statins on colorectal carcinogenesis. Methods A systematic review of the PubMed and Cochrane databases was performed to identify studies published between April 2010 and April 2018 that investigated the association between statin use and colorectal cancer incidence, mortality, and treatment. Results Overall, 126 articles were identified with our search strategy. Based on the eligibility criteria, 69 studies were excluded from the review process. In vitro and animal studies have shown a potential chemopreventive effect of statins and their efficacy in adjuvant therapy of colorectal cancer. The anticarcinogenic effect on cancer risk in human studies was heterogeneous. Some studies reported better overall and cancer specific survival rates in patients using statins before and during colorectal cancer treatment. Statins also show a potential role in chemoprevention of colorectal cancer in patients with inflammatory bowel disease. Conclusions Accumulating evidence suggests that statins may have a role in colorectal cancer prevention and treatment. Further studies are necessary to define the associations between individual statin characteristics, their doses and colorectal cancer.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2wkfupI
Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients with Prediabetes
Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0664-7583
Aim To evaluate the effect of dapagliflozin on insulin secretion and insulin sensitivity in patients with prediabetes. Methods A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 adults diagnosed with prediabetes and without pharmacological treatment. Patients were randomly assigned into two groups of 12 patients each to receive 10 mg of oral dapagliflozin or placebo once a day during 12 weeks. At baseline and at the end of the study, anthropometric and metabolic measurements were evaluated, including the first phase of insulin secretion, total insulin secretion, and insulin sensitivity. Results After dapagliflozin administration, there were significant decreases in body weight (80.8±16.3 vs. 77.8±14.9 kg, p=0.019), body mass index (30.3±3.5 vs. 29.2±3.1 kg/m2, p=0.023), waist circumference (100.6±13.5 vs. 96.2±11.8 cm, p=0.003), fasting glucose (5.9±0.4 vs. 5.1±0.3 mmol/L, p<0.001) and uric acid (334.3±70.8 vs. 262.9±60.7 mmol/L, p=0.032), with a tendency to increase the insulin sensitivity (1.94±0.72 vs. 2.63±1.04, p=0.064). Conclusion Dapagliflozin administration in patients with prediabetes decreased body weight, body mass index, waist circumference, fasting glucose, and uric acid, with a tendency to increase the insulin sensitivity without changes in insulin secretion.
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© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2C1hl8e
``Re-Using the internal mammary artery as recipient artery in cervicofacial reconstruction by fibular flap''
We have read with great interest Decaudaveine's anatomical study entitled "Using the internal mammary artery as recipient artery in cervicofacial reconstruction by fibular flap".1 We congratulate the authors for their interesting and innovative work, opening new perspectives of maxillofacial reconstructive surgery in patients with vessel-depleted neck area. We published last year a quite similar study in Surgical and Radiologic Anatomy.2 This paper was based on a medical thesis defended in our Faculty in 2016.
https://ift.tt/2wgzHMY
Letter responds to comment on published paper: “Using the internal mammary artery as recipient artery in cervicofacial reconstruction by fibular flap”
We have received the letter of J. Adnot about our study entitled "Using the internal mammary artery as recipient artery inervicofacial reconstruction by fibular flap" 1 and read it with great interest.
https://ift.tt/2wiquDK
One-Stage Treatment for Maxillo-Facial Asymmetry with Orthognathic and Contouring Surgery using virtual surgical planning and 3D-printed surgical templates
Asymmetry is one of the most common maxillo-facial deformities. One-stage treatment for maxillo-facial asymmetry with orthognathic and contouring surgery has been rarely reported. This retrospective study aims to investigate the feasibility of simultaneous orthognathic and facial bone contouring surgery with the help of virtual surgical planning and 3D-printed navigation templates for facial asymmetry.
https://ift.tt/2NoTmB3
Risk factors for developing capsular contracture in women after breast implant surgery: A systematic review of the literature
We thank Dr. Altundag for his interest in our review about risk factors for developing capsular contracture after breast implant surgery.1 Dr. Altundag postulates that adjuvant radiotherapy is also an important risk factor.
https://ift.tt/2wj795z
Annual variation patterns of the effluent water quality from a green roof and the overall impacts of its structure
Abstract
To explore the optimal combination of vegetation type, substrate type, and substrate thickness in a green roof and the interannual variation patterns of the runoff quality, eight green roof units were constructed in Shenzhen, China. Runoff quality of the eight units was monitored for 3 years (24 rainfall events). The rainfall event mean concentrations (EMC) were used to evaluate runoff quality as well as annual pollutant load. An orthogonal L8(24) experiment was designed to verify the significance of different factors. An optimal level of significant factors was selected to determine the optimal design of green roof. The optimal vegetation was Ophiopogon japonicus. The optimal substrate was modified perlite, while optimal substrate thickness was 200 mm. A three-year interannual variation analysis was performed on the optimal green roof. It was found that the interannual variation of each runoff quality index is different. The concentrations of SS, COD, and NH4+-N in the runoff decreased with years. The concentration of NO3−-N increased over time, while TP remained stable. The concentration of TN had certain volatility with no significant interannual variation. Overall, the runoff quality of the green roof improves over time. The optimal green roof's runoff quality in the third year including 11 rainfall events was monitored. Results showed that the effluent quality from the green roof was lower than that of precipitation. The average concentrations of SS, COD, NH4+-N, TN, and TP decreased respectively by 37.85%, 28.89%, 30.25%, 14.52%, and 12.93%, but NO3−-N increased by 69.91% comparing to the traditional roof.
https://ift.tt/2MUqQKx
Formation of 1,3,8-tribromodibenzo- p -dioxin and 2,4,6,8-tetrabromodibenzofuran in the oxidation of synthetic hydroxylated polybrominated diphenyl ethers by iron and manganese oxides under dry conditions
Abstract
Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are ubiquitous and highly toxic emerging endocrine disruptors found in surface and subsurface soils and clay deposits. Seriously, they could be easily transformed to the more toxic dioxins (PBDD/Fs) in photochemical processes and incineration, but the spontaneous formation of PBDD/Fs has rarely been reported. This study focused on the formation of 1,3,8-tribromodibenzo-p-dioxin (1,3,8-TrBDD) and 2,4,6,8-tetrabromodibenzofuran (2,4,6,8-TeBDF) from 2′-OH-BDE-68 and 2,2′-diOH-BB-80 under the oxidization of iron and manganese oxides (goethite and MnOx). Approximately 0.09 μmol/kg (2.33%) and 0.17 μmol/kg (4.15%) were transformed to 1,3,8-TrBDD and 2,4,6,8-TeBDF by goethite in 8 days and a higher conversion 0.15 μmol/kg (3.77%) and 0.23 μmol/kg (5.74%) were observed for MnOx in 4 days. However, the formation of PBDD/Fs, probably proceeding via Smiles rearrangements and bromine elimination processes, was greatly inhibited by the presence of water. Transformation of OH-PBDEs by goethite and MnOx was accompanied by release of Fe and Mn ions and the possible pathways for the formation of reaction products were proposed. In view of the ubiquity of OH-PBDEs and metal oxides in the environment, oxidation of OH-PBDEs mediated by goethite and MnOx is likely an abiotic route for the formation of PBDD/Fs.
https://ift.tt/2ocw3zj
Acute effects of air pollution on type II diabetes mellitus hospitalization in Shijiazhuang, China
Abstract
Air pollution has been considered as an important contributor to diabetes development. However, the evidence is fewer in developing countries where air pollution concentrations were much higher. In this study, we conduct a time-series study to investigate the acute adverse effect of six air pollutants on type II diabetes mellitus (T2DM) hospitalization in Shijiazhuang, China. An over-dispersed passion generalized addictive model adjusted for weather conditions, day of the week, and long-term and seasonal trends was used. Finally, a 10-μg/m3 increase of fine particulate matter (PM2.5), inhalable particulate matter (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and carbon monoxide (CO) corresponded to 0.53% (95% confidence interval = 0.22–0.83), 0.32% (95% CI = 0.10–0.55), 0.55% (95% CI = 0.04–1.07), 1.27% (95% CI = 0.33–2.22), and 0.04% (95% CI = 0.02–0.06) increment of T2DM hospitalization, respectively. The effects of PM2.5, PM10, and CO were robust when adjusted for co-pollutants. The associations appeared to be a little stronger in the cool season than in the warm season. And stronger associations were found in male and elderly (≥ 65 years) than in female and younger people (35–65 years). Our results contribute to the limited data in the scientific literature on acute effects of air pollution on type II diabetes mellitus in developing countries. Main findings: This is the first adverse effect evidence of air pollution on T2DM in Shijiazhuang, a severely polluted city in China. Males were more vulnerable than females in severe pollution.
https://ift.tt/2wi7uFp
Decision between contralateral and ipsilateral DIEP flap harvesting for unilateral breast reconstruction
Abstract
Background
Deep inferior epigastric artery perforator flap (DIEP/DIEAP) procedure is a common method for breast reconstruction after mastectomy. For unilateral breast reconstruction, harvesting of the flap can be done contralaterally or ipsilaterally. The aim of this study is to demonstrate a possible side difference in quality of abdominal skin perfusion from left to right and its causes, which could have implications on our selection of flap harvesting side, operating time, and flap design itself.
Methods
We performed thermographic imaging after induced hypothermia of the abdominal skin in 17 females to evaluate the quality of blood supply to each side of the abdominal wall. Additionally, we examined the diameter of the deep inferior epigastric artery, whether there is a difference in size correlating to the quality of blood supply of each side. Evaluation of our pre-operative thermographic imaging method was performed in four patients which underwent unilateral DIEP flap reconstruction regarding reduction of surgery time and assessment of overall outcome.
Results
Every subject showed a dominant side of perfusion (greater area of perfusion after set time). Furthermore, we discovered a side difference between left and right diameter of the deep inferior epigastric artery in each patient (0.2-mm mean difference; p = 0.0002). The rewarming process of the abdominal skin was faster (16 out of 17 subjects; 94.1%) (greater area of rewarming after set time) on the side with the greater diameter deep inferior epigastric artery. In our DIEP patients using thermographic imaging of the abdominal skin, we only performed perforator dissection on the preferable side. The consequence was a reduction in operating time of 25 minutes compared to careful dissection of both sides. None of our patients showed complications such as wound-healing disorders.
Conclusions
Thermographic assessment of the abdominal skin after hypothermia is easy to conduct and gives reproducible information about different areas of skin perfusion quality. The difference in rewarming speed from left to right is thought to be due to a larger diameter deep inferior epigastric artery, which translates into a superior perfusion, but does not necessarily correlate with the size of the perforators itself. The presented technique offers the potential to improve outcome, especially by lowering perfusion-related complications and reducing operation time by fast dissection of the non-dominant side while carefully dissecting the area of interest with fast thermographic rewarming results, and must therefore be investigated in future studies by measuring objective outcome results.
Level of Evidence: Level III, risk/prognostic
https://ift.tt/2MWBMak
CO 2 bio-fixation and biofuel production in an airlift photobioreactor by an isolated strain of microalgae Coelastrum sp. SM under high CO 2 concentrations
Abstract
Microalgae cultivation is a promising approach to remove ambient CO2 via photosynthesis process. This paper investigates the impact of high CO2 concentrations (6, 12, and 16%) on algae growth, CO2 biofixation, lipid and carbohydrate contents, and nutrient removal of newly isolated microalgae, Coelastrum sp. SM. In addition, the ability of microalgae to produce biodiesel at optimal condition was studied. The microalgae were cultivated in wastewater using an airlift photobioreactor. Under 12% CO2, the maximum biomass productivity and CO2 fixation rate were 0.267 g L−1 day−1 and 0.302 g L−1 h−1, respectively. Total Kjeldahl nitrogen (TKN), total phosphorous (TP), nitrate, and sCOD removal efficiency were 84.01, 100, 86.811, and 73.084%, respectively. Under 12% CO2 and at the same condition for cell growth, the highest lipid and carbohydrate contents were 3 7.91 and 58.45%, respectively. The composition of fatty acids methyl ester (FAME) of the microalga lipid was defined. Based on the obtained results and FAME profile, Coelastrum sp. SM was a suitable feedstock for biodiesel production and also, the organism had a great potential for CO2 biofixation, which is also more suitable than any other reported strains in other related studies.
https://ift.tt/2Pbz8v2
The Application of Fluorescence Laparoscopy in the Treatment of Adenocarcinoma of the Esophagogastric Junction
Conditions: Fluorescence Laparoscopy; Adenocarcinoma of the Esophagogastric Junction
Interventions: Procedure: fluorescent laparoscopic radical gastrectomy; Procedure: traditional laparoscopic radical gastrectomy
Sponsor: Dong Yang
Not yet recruiting
https://ift.tt/2oeE9rf
Interventions: Procedure: fluorescent laparoscopic radical gastrectomy; Procedure: traditional laparoscopic radical gastrectomy
Sponsor: Dong Yang
Not yet recruiting
https://ift.tt/2oeE9rf
Lesion Dosimetry With Iodine-124 in Metastatic Thyroid Carcinoma
Conditions: Thyroid Carcinoma; Metastatic Thyroid Carcinoma
Interventions: Device: PET/CT Scan; Drug: Iodine-124
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
https://ift.tt/2BR2jl9
Interventions: Device: PET/CT Scan; Drug: Iodine-124
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
https://ift.tt/2BR2jl9
EBV-TCR-T（YT-E-001） for Patients With EBV-positive Recurrent or Metastatic NPC Patients
Condition: Nasopharyngeal Carcinoma
Intervention: Biological: EBV-TCR-T (YT-E001) cells
Sponsors: Fujian Cancer Hospital; China Immunotech Co., Ltd.
Not yet recruiting
https://ift.tt/2oe2VaQ
Intervention: Biological: EBV-TCR-T (YT-E001) cells
Sponsors: Fujian Cancer Hospital; China Immunotech Co., Ltd.
Not yet recruiting
https://ift.tt/2oe2VaQ
Pain in Parkinson's Disease With Motor Fluctuations.
Condition: Parkinson Disease
Interventions: Drug: safinamide metansolfonato (12 weeks); Drug: rasagilina mesilato (12 weeks)
Sponsors: Universita di Verona; Azienda Ospedaliera Universitaria Integrata Verona
Recruiting
https://ift.tt/2BSKbHG
Interventions: Drug: safinamide metansolfonato (12 weeks); Drug: rasagilina mesilato (12 weeks)
Sponsors: Universita di Verona; Azienda Ospedaliera Universitaria Integrata Verona
Recruiting
https://ift.tt/2BSKbHG
177Lu-PP-F11N in Combination With Sacubitril for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer
Condition: Thyroid Cancer, Medullary
Interventions: Drug: 177Lu-PP-F11N; Drug: Sacuitril
Sponsors: University Hospital, Basel, Switzerland; Krebsforschung Schweiz, Bern, Switzerland; Center for Proton Therapy, Paul Scherrer Institute, Villigen,Switzerland; University Hospital, Zürich; University Hospital Freiburg
Not yet recruiting
https://ift.tt/2okImK9
Interventions: Drug: 177Lu-PP-F11N; Drug: Sacuitril
Sponsors: University Hospital, Basel, Switzerland; Krebsforschung Schweiz, Bern, Switzerland; Center for Proton Therapy, Paul Scherrer Institute, Villigen,Switzerland; University Hospital, Zürich; University Hospital Freiburg
Not yet recruiting
https://ift.tt/2okImK9
Predictor Analysis of Acute Radiation Oral Mucositis in NPC Patients Treated With IMRT/TOMO Combined Chemotherapy
Condition: Nasopharyngeal Carcinoma
Intervention:
Sponsor: Zhejiang Cancer Hospital
Recruiting
https://ift.tt/2BSK276
Intervention:
Sponsor: Zhejiang Cancer Hospital
Recruiting
https://ift.tt/2BSK276
Hurley III Hidradenitis Suppurativa Has an Aggressive Disease Course
Dermatology
https://ift.tt/2BQscBv
A Comparison of Vagal Nerve Stimulation and Responsive Neurostimulation for the Treatment of Medically Refractory Complex Partial Epilepsy
Background: Neuromodulatory applications such as vagus nerve stimulation (VNS) and responsive neurostimulation (RNS) are safe and effective strategies for medically intractable epilepsy secondary to complex partial seizures, but researchers have yet to compare their efficacies. Objective: The goal of this study is to compare VNS and RNS efficacy at reducing seizure frequency and complication rates in subjects with medically intractable epilepsy secondary to complex partial seizures. Methods: This is a retrospective chart review of 30 patients with medically intractable complex partial epilepsy, who underwent either VNS or RNS placement at a single institution between June 2012 and January 2016. There was a mean follow-up of 19 months. Seizure frequency reduction and complications were identified. Results: The median seizure frequency reduction was similar for VNS (66%) and RNS (58%). There was no major morbidity or mortality, and the frequency of minor complications was similar between VNS (15%) and RNS (18%). Conclusion: We found that VNS and RNS reduced the median seizure frequency similarly with no difference in morbidity or mortality. Further prospective studies are warranted as VNS and RNS therapy improves over time.
Stereotact Funct Neurosurg
https://ift.tt/2BZ1FSW
Stereotact Funct Neurosurg
https://ift.tt/2BZ1FSW
Association of Postoperative Antibiotics With Surgical Site Infection in Mohs Micrographic Surgery
BACKGROUND Surgical site infection (SSI) is the most frequent complication of Mohs micrographic surgery. Previous studies have identified risk factors for SSI, but it is not known whether antibiotic prophylaxis mitigates this risk. OBJECTIVE To measure the association between antibiotic prophylaxis and SSI in a convenience sample of Mohs cases and to report on the utility of propensity scoring to control for confounding by indication in registry data. METHODS Data were drawn from a pilot quality improvement registry of 816 Mohs cases. The relationship between antibiotic prophylaxis and SSI was assessed with logistic regression modeling using propensity score methods to adjust for confounding. RESULTS One hundred fifty-one cases were prescribed antibiotic prophylaxis (18.5%). Of 467 cases with follow-up, 16 (3.4%) developed SSI. Infection rates were higher in subjects prescribed prophylaxis, but propensity adjustment reduced this effect. Adjusted odds of infection were 1.47-fold higher in subjects prescribed antibiotics and not statistically significant (95% confidence interval 0.29–7.39; p = .64). CONCLUSION Although there was no significant difference in SSI among patients prescribed prophylactic antibiotics, statistical precision was limited by the low incidence of infection. Larger population-based prospective registry studies including propensity adjustment are needed to confirm the benefit of prophylactic antibiotics in high-risk surgical cases. Address correspondence and reprint requests to: Sarah T. Arron, MD, PhD, Department of Dermatology, University of California, 1701 Divisadero Street 3rd Floor, San Francisco, CA 94115, or e-mail: Sarah.Arron@ucsf.edu The authors have indicated no significant interest with commercial supporters. © 2018 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
https://ift.tt/2Lti2qh
https://ift.tt/2Lti2qh
Intracytoplasmic eosinophilic inclusion bodies with embryonic folliculosebaceous‐apocrine unit differentiation in syringocystadenoma papilliferum
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2od8Ahi
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Summary Insulinomas are rare neuroendocrine tumours that classically present with fasting hypoglycaemia. This case report discusses an un...
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