Bilateral extracephalic transcranial direct current stimulation improves endurance performance in healthy individuals

Publication date: Available online 5 October 2017
Source:Brain Stimulation
Author(s): L. Angius, A.R. Mauger, J. Hopker, A. Pascual-Leone, E. Santarnecchi, S.M. Marcora
BackgroundTranscranial direct current stimulation (tDCS) has been used to enhance endurance performance but its precise mechanisms and effects remain unknown.ObjectiveTo investigate the effect of bilateral tDCS on neuromuscular function and performance during a cycling time to task failure (TTF) test.MethodsTwelve participants in randomized order received a placebo tDCS (SHAM) or real tDCS with two cathodes (CATHODAL) or two anodes (ANODAL) over bilateral motor cortices and the opposite electrode pair over the ipsilateral shoulders. Each session lasted 10 min and current was set at 2 mA. Neuromuscular assessment was performed before and after tDCS and was followed by a cycling time to task failure (TTF) test. Heart rate (HR), ratings of perceived exertion (RPE), leg muscle pain (PAIN) and blood lactate accumulation (ΔB[La⁻]) in response to the cycling TTF test were measured.ResultsCorticospinal excitability increased in the ANODAL condition (P < 0.001) while none of the other neuromuscular parameters showed any change. Neuromuscular parameters did not change in the SHAM and CATHODAL conditions. TTF was significantly longer in the ANODAL (P = 0.003) compared to CATHODAL and SHAM conditions (12.61 ± 4.65 min; 10.61 ± 4.34 min; 10.21 ± 3.47 min respectively), with significantly lower RPE and higher ΔB[La⁻] (P < 0.001). No differences between conditions were found for HR (P = 0.803) and PAIN during the cycling TTF test (P = 0.305).ConclusionOur findings demonstrate that tDCS with the anode over both motor cortices using a bilateral extracephalic reference improves endurance performance.



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Correlation of lysosome-associated protein transmembrane-4β gene overexpression with the malignant phenotypes of hepatocellular carcinoma

Publication date: Available online 7 October 2017
Source:Pathology - Research and Practice
Author(s): Hongying Su, Tao Xu, Xiongfei Huang, Shengbing Zang, Bin Wang, Yang Huang, Jingfeng Liu, Aimin Huang
Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies, for which hepatitis B virus (HBV) chronic infection constitutes a major risk factor. The lysosome-associated protein transmembrane-4 β gene (LAPTM4B) is a recently identified gene that was found to be overexpressed in several types of cancer. However, the role of LAPTM4B in HCC tumorigenesis and progression has not been clearly determined. The present study demonstrated that the mRNA as well as the protein levels of LAPTM4B were significantly upregulated in HCC specimens. Patients with higher levels of LAPTM4B mRNA in their HCC tissues tended to be of a younger age, HBsAg+, with an advanced Barcelona Clinic Liver Cancer stage. Moreover, LAPTM4B mRNA expression was positively associated with serum α −fetoprotein levels. We also observed that LAPTM4B was able to promote HCC cell proliferation, migration and invasion in vitro. In conclusion, our results indicated that LAPTM4B plays an important role in the promotion of hepatocarcinogenesis and cancer progression and may serve as a biomarker for the diagnosis and monitoring of HCC.



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A TERT-CLPTM1 locus polymorphism (rs401681) is associated with EGFR mutation in non-small cell lung cancer

Publication date: Available online 7 October 2017
Source:Pathology - Research and Practice
Author(s): Deok Heon Lee, Yu-Ran Heo, Won-Jin Park, Jae-Ho Lee
Telomere length is associated with lung carcinogenesis, and recent studies have focused on telomere-maintaining genes and their polymorphisms. Cancer susceptibility of the rs401681 polymorphism, located in the TERT-CLPTM1L locus, has been studied in many cancers. We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer. The relationship between rs401681 variants and telomere length was analyzed in 134 non-small cell lung cancers (NSCLCs). The rs401681 polymorphism had the following genotype frequencies: C/C in 52.2% of the samples, C/T in 30.6%, and T/T in 17.2%. The T allele showed a strong correlation with EGFR mutation (p=0.037). Telomeres in the tumor samples were 3.26-fold longer, on average, than telomeres in matched normal samples (SD=0.48), and there were no differences in telomere length according to rs401681 polymorphism. Smoking was associated with telomere shortening (p=0.01). Survival analysis showed no prognostic value for rs401681 polymorphisms or telomere length in NSCLC. These results suggested that the rs401681 polymorphism contributes to lung carcinogenesis only in patients harboring an EGFR mutation. However, the polymorphism was not associated with survival; therefore, further comprehensive analysis should be performed.



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Vocalic transitions as markers of speech acoustic changes with STN-DBS in Parkinson’s Disease

Publication date: Available online 7 October 2017
Source:Journal of Communication Disorders
Author(s): Vincent Martel Sauvageau, Kris Tjaden
PurposeDeep Brain Stimulation of the subthalamic nucleus (STN-DBS) effectively treats cardinal symptoms of idiopathic Parkinson's disease (PD) that cannot be satisfactorily managed with medication. Research is equivocal regarding speech changes associated with STN-DBS. This study investigated the impact of STN-DBS on vocalic transitions and the relationship to intelligibility.MethodsEight Quebec-French speakers with PD and eight healthy controls participated. The slope of the second formant frequency (F2 slope) for glides was obtained. Locus equations (LEs) were calculated to capture vocalic transitions in consonant-vowel sequences. A visual analog scale was used to obtain judgments of intelligibility. Measures for the PD group were obtained both On and Off stimulation.ResultsF2 slopes and LEs differed among groups, but there were no systematic differences for On versus Off STN-DBS. On an individual level, participants with PD exhibited heterogeneous changes with DBS stimulation. Intelligibility was significantly correlated with F2 slope.ConclusionF2 slope appears to be sensitive to articulatory impairment in PD and could be used in clinical settings to distinguish these speakers from healthy controls. However, acoustic metrics failed to identify systematic change with STN-DBS. The heterogeneity of results, as well as the clinical relevance of acoustic metrics are discussed.



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Scholar : These new articles for Amyloid are available online

The online platform for Taylor & Francis Online content New for Amyloid and online now on Taylor & Francis Online: Letter to the Editor Pitfalls in conducting prospective trials in stage III cardiac amyloidosis – experience from the REVEAL study Elizabeth H. Phillips, Stephen Nash, Toyin Adedayo, Carol J. Whelan, Marianna Fontana, Shameem Mahmood, Helen J. Lachmann, Julian D. Gillmore, Paul Smith, Laura Clifton-Hadley, Philip N. Hawkins & Ashutosh D. Wechalekar Pages: 1-3 | DOI: 10.1080/13506129.2017.1385453 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

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The online platform for Taylor & Francis Online content New for Crystallography Reviews and online now on Taylor & Francis Online: Book Review Writing chemistry patents and intellectual property: a practical guide John R. Helliwell Pages: 1-2 | DOI: 10.1080/0889311X.2017.1383402 Browse papers on image & data fusion, GIS, LiDAR & more in the International Journal of Image and Data Fusion's exclusive Editor's Choice collection. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Cricotracheal resection - νέα αποτελέσματα

Single Stage Surgery for Cricotracheal Stenosis; The experience of Single Tertiary Center

O Kuşcu, F Özer, RÖ Günaydın, MU Akyol, T Yılmaz - Acta Medica, 2017

... Methods: The patients with cricotracheal stenosis who were treated with single stage surgery
with cricotracheal or tracheal resection between 2009 and 2015 at Hacettepe University Hospitals
Department of Otorhinolaryngology Head and Neck Surgery were evaluated ...

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Scholar : ΜΕΝΙΕΡΕ - νέα αποτελέσματα

[HTML] MICHAEL J. RUCKENSTEIN, MD, MSc, FACS

LA GOODSTEIN - Consultant, 2017

... 1998;124(3): 249-258. 9. Green JD Jr, Blum DJ, Harner SG. Longitudinal followup of patients
with Meniere's disease. Otolaryngol Head Neck Surg. 1991;104:783-788. 10. Ruckenstein MJ,
Rutka JA, Hawke M. The treatment of Meniere's disease: Torok revisited. Laryngoscope. ...

[PDF] The Significance of the Application of pico-Tesla TMS with MEG Systems in Greek Population

P Anninos, A Adamopoulos, A Kotini, N Tsagas - 2017

... encephalopathy. There was an improvement of the clinical findings after the application
of pT-TMS with proper field characteristics. pico-Tesla TMS and Meniere Syndrome
Anninos et al. [23] investigated Meniere's syndrome. Using ...

Canal-Based Surgery: Does Surgery in the Vestibular Labyrinth Preserve its Functionality? Review of the Literature and Our Institutional Experience

R Ishai, G Tsang, J Rutka - Current Otorhinolaryngology Reports, 2017

... The first reports of labyrinthectomy suggest they were per- formed exclusively for suppurative
labyrinthitis [1]. Early de- velopments of surgical techniques for inner ear disorders such as
Meniere's disease including both endolymphatic sac sur- gery and transtympanic utricular ...

[HTML] Redo microvascular decompression in a patient of resistant cochleovestibular nerve compression syndrome

I Bishnoi, T Mewada, D Singh, H Singh - Asian Journal of Neurosurgery, 2017

... There was no relief after vomiting or lying down. She first consulted ENT specialist and was
diagnosed as a case of "Meniere's Disease." She underwent two procedures, first was injection
Gentamycin in the left ear, 3 years back and there was no relief. ...

[PDF] The short hyperacusis questionnaire: A tool for the identification and measurement of hyperacusis in the Italian tinnitus population

F Tortorella, S Pavaci, AB Fioretti, F Masedu… - Audiology Research, 2017

... In a similar way, we excluded patients affected with Meniere's disease because a sensorineural
hearing loss (SNHL) for the medium-low frequencies is often present in this pathology and the
tonal audiometric curve can undergo some variations during recrudescence of the ...

Current Management of Benign Epithelial Gastric Polyps

AR Cheesman, DA Greenwald, SC Shah - Current Treatment Options in Gastroenterology

... Solitary. Typical size. < 5 mm (1–8 mm), sessile. 1–2 cm (single), < 1 cm (multiple). Vary in size,
but rarely > 2 cm. Syndromic associations. FAP. Meniere's etc. Association with H. pylori infection
a. Not established (HP infection may be protective). Yes. No. Association with PPI use ...

[PDF] Survey of the Current Status of Vestibular Practices in the United States

KJ Lingen - 2017

Page 1. University of Northern Colorado Scholarship & Creative Works @ Digital
UNC Capstones Student Research 8-2017 Survey of the Current Status of Vestibular
Practices in the United States Kelli Jean Lingen Follow this ...

[HTML] L'omeopatia nei disturbi del comportamento indotti dai farmaci-Un caso clinico

N Chiaramida

... idiosincrasiche agli antistaminici sopradescritte. Vertigini Alcuni antistaminici possono
essere efficaci nella terapia di sindromi vertiginose, come la malattia di Meniere ed
altri tipi di vertigini (62). Inoltre alcuni antistaminici sono ...

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Scholar : Decannulation - νέα αποτελέσματα

Single Stage Surgery for Cricotracheal Stenosis; The experience of Single Tertiary Center

O Kuşcu, F Özer, RÖ Günaydın, MU Akyol, T Yılmaz - Acta Medica, 2017

... Postoperative restenosis rate and additional intervention requirement for decannulation were
compared with stenosis grade and comorbidity. ... All patients underwent single stage surgery and
followed at ICU as an intubated. Overall decannulation rate was 93.7%. ...

[PDF] An Interdisciplinary Approach to the Management of Idiopathic Subglottic Stenosis in Pregnancy

L Miller, H Khan, D Walner - J Gynec Obstet, 2017

... section at term. Beginning two months postpartum, successful serial balloon dilations
led to resolution of the restenosis and subsequent decannulation of the tracheostomy
and resolution of the problem. Conclusion: This case ...

[HTML] Editorial on tracheal resection and reconstruction

DJ Mathisen - Shanghai Chest, 2017

... Patients with tracheal stenosis may present in acute respiratory distress. There is
often a history of recent intubation or decannulation from a tracheostomy tube to
give a high-index of suspicion that tracheal stenosis may exist. ...

Surgical Management of Neonatal Ebstein's Anomaly Associated With Circular Shunt

C Elzein, S Subramanian, M Ilbawi - World Journal for Pediatric and Congenital Heart …, 2017

Ebstein's anomaly is a rare congenital cardiac malformation that may present in the neonatal
period with life-threatening physiologic derangement, especially wh...

[PDF] Tracheostomy: A hospital based descriptive study

A Menon, R Deepa, E Balakrishnan, A Mukundan…

... The use of multidisciplinary teams and protocols for tracheostomy care can decrease morbidity,
result in earlier decannulation, and generally improve the quality of life of tracheostomy patients17. ...
After decannulation patient was observed for 24 hours and was sent home. ...

[HTML] Inspiratory Muscle Training in the Intensive Care Unit: A New Perspective

RM Tonella, LDSR Ratti, LEB Delazari, CF Junior… - Journal of Clinical Medicine …, 2017

... carried out in an intermediate care unit. A 30-cm H 2 O increase in MIP was observed
after 2 weeks, allowing MV discontinuation, decannulation, and initiation of
non-invasive MV. Therefore, in accordance with the results of ...

… DecanulAR. Factores predictores de dificultad para la decanulación Estudio de cohorte multicéntrico DecanulAR. Predictors of Decannulation Difficulty. A Multicenter …

DB Pablo, V Darío, A Mauro, E Miguel, MV Gastón…

EDITORIAL La memoria de Shakespeare Quadrelli Silvia - Editora en Jefe RAMR ... Cuando
el problema es infrecuente, todos los datos son valiosos Ibarrola Manuel ... PERSPECTIVAS
Indicadores de los estudios de diagnóstico de los trastornos respiratorios vinculados al sueño

Color Duplex Ultrasound in Dialysis Access Surveillance

MR Back, DF Bandyk - Noninvasive Vascular Diagnosis, 2017

... Mechanisms of thrombosis in low-flow, non-stenotic access includes interval development
of heart failure, hypovolemia, hypotension, hypercoagulability, or extrinsic pressure on the
graft (eg, particularly during access decannulation). Table 33.1 ...

[DOC] Dysphagia café blog–October 2015

L Chen

... those with the cuff inflated. Romero (2010) found that 38% of non-neurological patients
had swallowing problems, resulting in delayed decannulation and an increased length
of stay. More recently Hernandez (2013) found that ...

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