Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Σάββατο 27 Μαΐου 2017
Greater Omental Lymph Node Flap for Upper Limb Lymphedema with Lymph Nodes–depleted Patient
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Characteristics and Outcomes of Patients with Profound Hyponatremia due to Primary Polydipsia
Abstract
Objective
Hyponatremia due to excessive fluid intake (i.e. primary polydipsia (PP)) is common. It may culminate in profound hyponatremia—carrying considerable risk of morbidity. However, data on patients with PP leading to hyponatremia is lacking. Herein, we describe the characteristics of polydiptic patients hospitalised with profound hyponatremia, and assess one-year outcomes.
Design
Substudy of the prospective observational Co-MED Study.
Patients
Patients with an episode of profound hyponatremia (≤125mmol/l) due to PP in the medical emergency were eligible and classified into psychogenic polydipsia (PsyP), dipsogenic polydipsia (DiP), and beer potomania (BP).
Measurements
Symptoms, laboratory findings, and factors contributing to hyponatremia (comorbidities, medication, and liquid intake) were assessed. A one-year follow-up was performed to evaluate recurrence of hyponatremia, re-admission rate, and mortality.
Results
23 patients were included (median age 56 years [IQR 50-65], 74% female), 7 had PsyP, 8 DiP, and 8 BP. Median serum sodium of all patients was 121mmol/l (IQR 114-123), median urine osmolality 167mmol/l (IQR 105-184), and median copeptin 3.6mmol/l (IQR 1.9-5.5). Psychiatric diagnosis, particularly dependency disorder (43%) and depression (35%), were highly prevalent. Factors provoking hyponatremia were found in all patients (e.g. acute water load, medication, stress).
During the follow-up period, 67% of patients were readmitted, 52% of these with re-hyponatremia, and 3 patients (38%) with BP died.
Conclusion
Patients with PP are more likely to be female, and have addictive and affective disorders. Given the high recurrence, re-hospitalisation, and mortality rate, careful monitoring and long-term follow-up including controls of serum sodium, education and behavioural therapy is needed.
This article is protected by copyright. All rights reserved.
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Light-induced antibacterial and UV-protective properties of polyamide 56 biomaterial modified with anthraquinone and benzophenone derivatives
Publication date: 15 September 2017
Source:Materials & Design, Volume 130
Author(s): Aiqin Gao, Hongjuan Zhang, Gang Sun, Kongliang Xie, Aiqin Hou
The bio-based material polyamide 56 (PA 56) is a new kind of biopolymer. Reactive Blue P-3R, which is a derivative of anthraquinone, can react directly with the amino groups on PA 56. 3,3′,4,4′-Benzophenone tetracarboxylic acid (BPTCA), which is a photoactive derivative of benzophenone, can also react directly with the amino groups on PA 56 to form amide bonds. The modified bio-based PA 56 fabrics not only exhibited excellent ultraviolet (UV) protective property, but also exhibited important photochemical properties, such as producing reactive oxygen species, including hydroxyl radicals (HO) under UV light exposure. The hydroxyl radical-generating abilities of these materials were measured, and their photochemical reactive mechanisms were discussed. The modified PA 56 fabrics demonstrated good antimicrobial activities against both E. coli and S. aureus. Reactive Blue P-3R and BPTCA exhibited good synergistic properties. These modified biomaterials could therefore be used in medical textiles and biological materials.
Graphical abstract
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High quality colloidal GdVO4:Yb,Er upconversion nanoparticles synthesized via a protected calcination process for versatile applications
Publication date: 15 September 2017
Source:Materials & Design, Volume 130
Author(s): Yanjie Liang, Hyeon Mi Noh, Junpeng Xue, Haeyoung Choi, Sung Heum Park, Byung Chun Choi, Jung Hwan Kim, Jung Hyun Jeong
GdVO4:Yb,Er upconversion nanoparticles with high crystallinity and water dispersibility have been synthesized by a facile hydrothermal approach followed by a protected calcination treatment. The crude GdVO4:Yb,Er nanoparticles obtained by hydrothermal approach show cubic morphology with a diameter of about 45nm. A layer of SiO2 was coated on the surface of nanoparticles to avoid particles growth and aggregation during thermal treatment. After the dissolution of SiO2 layer by chemical etching in aqueous NaOH solution, the as-prepared highly crystalline GdVO4:Yb,Er nanoparticles not only maintain their nanostructure properties but show high chemical stability and good water dispersibility. Intense green upconversion luminescence is achieved under the 980nm laser diode excitation. The approach reported here can be "borrowed" to guide the synthesis of other oxide-based luminescent nanoparticles and will access their suitability for many technologically important applications.
Graphical abstract
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Microstructural control during laser additive manufacturing of single-crystal nickel-base superalloys: New processing–microstructure maps involving powder feeding
Publication date: 15 September 2017
Source:Materials & Design, Volume 130
Author(s): Yao-Jian Liang, Xu Cheng, Jia Li, Hua-Ming Wang
The control of solidification microstructure is critical to successful laser processing of single-crystal (SX) nickel-base superalloys and a practical tool for the microstructural control is processing–microstructure maps. However, the maps presented in literature do not consider the effects of powder feeding during laser additive manufacturing (LAM) of SX superalloys. This paper therefore presents a simple and feasible strategy to deal with the effects of powder feeding and to extend the combined numerical model used to calculate processing–microstructure maps. A characteristic ratio of epitaxial SX growth was defined to quantitatively compare the final solidification microstructure. Resulting processing–microstructure maps can estimate the influence of most processing variables, especially powder feeding rate, on the extent of epitaxial SX growth and the position of columnar-to-equiaxed transition. Using the processing parameters selected according to these processing–microstructure maps, a multi-layer SX deposit with fine dendrites was successfully fabricated by LAM. This successful SX LAM indicates that these new processing–microstructure maps involving powder feeding are reliable and useful because they can determine proper processing windows for LAM of SX superalloys and further advance the understanding of the processing–microstructure relationship in powder-feeding LAM process.
Graphical abstract
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Tunable white light emitting Sr2V2O7:Bi3+phosphors: Role of bismuth ion
Publication date: 15 September 2017
Source:Materials & Design, Volume 130
Author(s): Santosh K. Gupta, K. Sudarshan, R.M. Kadam
Phase purity, optical properties and defects in new near white light emitting rare earth free Sr2V2O7:Bi3+phosphors were investigated. Emission spectrum of Sr2V2O7 displayed two peaks at all excitation wavelength approximately around 450 (P1) and 600nm (P2). With increase in the excitation wavelength; emission intensity increases and there is a red and blue shift in Peak P1 and P2, respectively. On bismuth doping, the two Peaks P1 and P2 slowly starts merging and become a single broad peak at 5% doping. Bismuth doping also reduces the emission peak energy. This is attributed to substitution of Bi3+ at Sr2+ site which would distort VO4 tetrahedra, thereby reducing the energy difference between the 3T and 1A levels of VO43− distorted tetrahedral. This dual role of bismuth doping and excitation energy leads to interesting tunability in white emission from cool to warm white. This opens a new arena in phosphor research because of great role of white LEDs (both warm and cool) in outdoor and indoor lighting.
Graphical abstract
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Overweight in elderly people induces impaired autophagy in skeletal muscle
Publication date: September 2017
Source:Free Radical Biology and Medicine, Volume 110
Author(s): Yaiza Potes, Beatriz de Luxán-Delgado, Susana Rodriguez-González, Marcela Rodrigues Moreira Guimarães, Juan J. Solano, María Fernández-Fernández, Manuel Bermúdez, Jose A. Boga, Ignacio Vega-Naredo, Ana Coto-Montes
Sarcopenia is the gradual loss of skeletal muscle mass, strength and quality associated with aging. Changes in body composition, especially in skeletal muscle and fat mass are crucial steps in the development of chronic diseases. We studied the effect of overweight on skeletal muscle tissue in elderly people without reaching obesity to prevent this extreme situation. Overweight induces a progressive protein breakdown reflected as a progressive withdrawal of anabolism against the promoted catabolic state leading to muscle wasting. Protein turnover is regulated by a network of signaling pathways. Muscle damage derived from overweight displayed by oxidative and endoplasmic reticulum (ER) stress induces inflammation and insulin resistance and forces the muscle to increase requirements from autophagy mechanisms. Our findings showed that failure of autophagy in the elderly deprives it to deal with the cell damage caused by overweight. This insufficiently efficient autophagy leads to an accumulation of p62 and NBR1, which are robust markers of protein aggregations. This impaired autophagy affects myogenesis activity. Depletion of myogenic regulatory factors (MRFs) without links to variations in myostatin levels in overweight patients suggest a possible reduction of satellite cells in muscle tissue, which contributes to declined muscle quality. This discovery has important implications that improve the understanding of aged-related atrophy caused by overweight and demonstrates how impaired autophagy is one of the main responsible mechanisms that aggravate muscle wasting. Therefore, autophagy could be an interesting target for therapeutic interventions in humans against muscle impairment diseases.
Graphical abstract
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Scholar : Scholar Alert - [ intitle:laryngeal ]
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Prenatal Nicotinic Exposure (PNE) Prolongs Superior Laryngeal C-Fibers (SLCFs)-mediated Apnea through Upregulating TRPV1 Receptor
death syndrome (SIDS). Simulation of SLCFs evokes an immediate apnea and
cardiovascular instability, which are potentially life-threatening and implicated in
Death by octopus (Macroctopus maorum): Laryngeal luxation and asphyxiation in an Indo‐Pacific bottlenose dolphin (Tursiops aduncus)
displacement and resultant suffocation caused by an intended prey item in various cetacean
species, most involving fish species either too large to be swallowed, or whose strong dorsal
human papilloma virus type 120-related papillomatosis mimicking laryngeal carcinoma
respiratory tract pathology was better understood in recent years and represents now an
issue of particular interest in carcinogenesis and in immunocompromised host. We describe
Morphological Characteristics of the Oropharyngeal Cavity (Tongue, Palate and Laryngeal Entrance) in the Eurasian Coot (Fulica atra, Linnaeus, 1758)
oropharyngeal cavity of the coot Fulica atra. For this purpose, the organs of six birds were
prepared to examine grossly and by SEM and stereomicroscope. The oval lingual apex had
[PDF] Use of deflation tool before sterilisation of the laryngeal
ofsterilisacions. The pressures of the laryngeal mask were measured after inflation of the cuff
with a volume of air at the recommended maximum volume (30 ml) and 50% greater volume
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