“Reporting Time Horizons in Randomized Controlled Trials in Plastic Surgery: A Systematic Review.”

Background: Current guidelines for randomized controlled trial (RCT) reporting do not require authors to justify their choice of time horizon. This is concerning, as the time horizon when an outcome is assessed has important implications for the interpretation of study results, and resources allocated to an investigation. Therefore, this study seeks to examine the standards of time horizon reporting in the plastic surgery literature. Methods: This is a systematic review of plastic surgery RCTs published within the last 4 years. The MEDLINE database was searched to yield relevant studies. All studies included were English language, prospective, non-pharmaceutical RCTs, comparing two plastic surgical interventions. Studies were classified into plastic surgery domains, and information regarding study population, time horizon reporting, and justification of chosen time horizons, was extracted. Results: The search retrieved 720 articles, of which 103 were eligible for inclusion. Time horizons were reported as either a standardized time point at which all patients were assessed, a follow-up duration range, or were not reported at all. Although most studies (85.4%) reported a standardized time horizon, the majority (85.4%) failed to provide a valid justification to support their selection of time horizons. Conclusion: Clinical investigators failed to justify their choice of time horizons in the majority of published RCTs. To limit heterogeneity, time horizons for given interventions should be standardized to improve validity of outcome assessments, enable future pooling of results, and increase research efficiency. The authors have no financial interests to declare. Corresponding Author: Achilleas Thoma, MD, MSc, 101-206 James Street South, Hamilton, ON L8P 3A9, Canada. athoma@mcmaster.ca, ©2018American Society of Plastic Surgeons

https://ift.tt/2OrhOlu

Compact and Economical Microsurgical Training made possible with Virtual Reality

No abstract available

https://ift.tt/2pd3dQ1

Understanding platelet function in microsurgical arterial anastomosis: the Charing Cross Clamp Technique

No abstract available

https://ift.tt/2Ol9K5O

Improvement of ternary fuel combustion with various injection pressure strategies in a toroidal re-entrant combustion chamber

Abstract

The present experimental work focuses on the influence injection pressure and toroidal re-entrant combustion chamber in a single cylinder diesel engine fuelled with ternary fuel (diesel-biodiesel-ethanol) blend. Ternary fuel (TF) is prepared by blending 70% diesel, 20% biodiesel, and 10% ethanol blends and its fuel properties were investigated and compared with diesel fuel. Since the physic-chemical properties of TF are well behind the diesel fuel, it is proposed to be blended with 20 ppm alumina nano additives which act as an ignition enhancer and catalytic oxidizer. The resulting fuel mixture (TF + 20 ppm alumina additive) is named as high performance fuel (HPF). Experimentations were conducted on HPF subjected to various injection pressures of 18 MPa, 20 MPa, 22 MPa, and 24 MPa respectively and are operated in toroidal re-entrant chamber geometry (TG) at an injection timing of 22 ^obTDC. From experimentation, it was identified that, for TG-HPF, higher injection pressure of 22 MPa ensued highest BTE (Brake Thermal Efficiency) of 35.5% and lowest BSEC (Brake Specific Fuel Consumption) of 10.13 MJ/kWh owing to the pooled effect of higher swirl formation, improved atomization enhanced evaporation rate, and better air-fuel mixing. Emission wise TG-HPF operated at 22 MPa lowered the HC (hydrocarbon), CO (carbon monoxide), and smoke emissions by 18.88%, 7.19%, and 5.02%, but with marginally improved NOx (oxides of nitrogen) and CO₂ (carbon dioxide) emissions by 3.92% and 3.89% respectively. In combustion point of view, it is observed that injection pressure increased the cylinder pressure, heat release rate (HRR), and cumulative heat release rate (CHRR) by 5.35%, 5.08%, and 3.38% respectively indicating improved combustion rate as a result of enhanced atomization, evaporation, and high turbulence inducement. Overall, it is concluded that operating the ternary fuel at 22 MPa injection pressure at toroidal re-entrant combustion chamber results in improved performance and minimized emissions.

https://ift.tt/2NMuSou

Fifth Euro‐Asian Congress of Dermatovenereologists, Riga, Latvia

Dermatologic Therapy, EarlyView.


https://ift.tt/2x97V5s

First case of secukinumab successful therapy in a very elderly psoriatic patient

Dermatologic Therapy, EarlyView.


https://ift.tt/2CRYCfq

Emotional eating and weight regulation: a qualitative study of compensatory behaviors and concerns

Abstract

Background

Emotional eating, or overeating in response to negative emotions, is a behavior endorsed by both normal weight and people with overweight/obesity. For some individuals, emotional eating contributes to weight gain and difficulties losing weight. However, there are also many who engage in emotional eating who maintain a normal weight. Little is known about the mechanisms by which these individuals are able to regulate their weight.

Methods

The present study seeks to gain insight into the behaviors of individuals of normal weight who engage in emotional eating through a series of one-on-one, 1-h long, qualitative interviews. Interviews were semi-structured and guided by questions pertaining to participants' compensatory behaviors used to regulate weight and concerns regarding their emotional eating. All interviews were transcribed and then objected to a thematic analysis of their content.

Results

The results of this analysis showed that participants endorsed using physical activity, controlling their eating behaviors, and engaging in alternative stress reduction and coping strategies to mitigate the effects of their emotional eating. They reported concern over the effects of emotional eating on their weight, body image, and health and saw this behavior as an unhealthy coping mechanism that was difficult to control.

Conclusions

These results suggest that programs promoting exercise, mindful eating, emotion regulation, and positive body image could have a positive effect on emotional eaters who struggle to maintain a healthy weight.

https://ift.tt/2xag0XH

Inhibition of return for body images in individuals with shape/weight based self-worth

Abstract

Background

Attentional biases for body shape and weight information have been found in people with eating disorders, indicating disorder-specific changes in the way this information is processed. To date, the literature has focused on the initial capture of attention, with little research on the maintenance of attention to shape/weight-related information. The current study aims to investigate the occurrence of attentional maintenance through the use of an Inhibition of Return task to shape and weight stimuli in those with and without an eating disorder.

Method

Three groups of female participants between the ages of 16–30 years undertook an Inhibition of Return task with target images of female bodies and control images of animals. The groups were an eating disorder group (n = 20), a High shape/weight based self-worth group (n = 23), and a Low shape/weight based self-worth group (n = 26).

Results

The results indicated differential patterns of Inhibition of Return between the High and Low shape/weight based self-worth groups. The High group displayed increased inhibition of return for the shape/weight stimuli relative to control stimuli, while the Low group displayed reduced inhibition of return for the shape/weight stimuli compared to control stimuli. The ED group displayed a similar pattern of results to the High group, but this did not reach significance.

Conclusion

The current findings indicate that young women without an eating disorder who base their self-worth on shape/weight display a pattern of avoidance of shape/weight stimuli that is in direct contrast to those at low risk of developing eating disorders. The possible implications of these specific patterns of inhibition of return across those at varying levels of risk for an eating disorder are discussed along with their implications for intervention approaches.

https://ift.tt/2Oh85yh

Environmental hazards associated with open-beach breaking of end-of-life ships: a review

Abstract

End-of-life (EOL) ships contribute significantly to the flow of recycled industrial Fe and non-Fe metal materials in resource-poor developing countries. The ship scrapping (breaking) and recycling industry (SBRI) recycles 90–95% of the total weight of EOL ships and is currently concentrated in Bangladesh, India, Pakistan, Turkey, and China, due to the high demand for recyclable and reusable materials there, an abundance of low-cost labor, and lenient environmental regulations. However, the SBRI has long been criticized for non-compliance with standards relating to occupational health, labor safety, and to the management of hazardous materials. Among the different EOL recycling options, Bangladesh, India, and Pakistan use open beaching, a technique that exposes all spheres of the environment to the release of hazardous materials from EOL ships. This article summarizes the current state of knowledge on the environmental exposure of hazardous materials from SBRI, to judge the risks associated with the dismantling of EOL ships on open beaches. Our work includes an overview of the industry and its recent growth, compares available ship-breaking methods, provides an inventory of hazardous releases from EOL ships, and reviews their movement into different spheres of the environment. The economic dynamics behind open beaching, and apportionment of responsibility for hazards related to it, are discussed, in order to generate policy and legal recommendations to mitigate the environmental harm stemming from this industry.

https://ift.tt/2NdSm6I

Determination of azole fungal residues in soils and detection of Aspergillus fumigatus -resistant strains in market gardens of Eastern France

Abstract

Medical azole antifungals are major compounds used to prevent and to treat invasive aspergillosis (IA). Azole fungicides, called DMI (14-alpha demethylase inhibitors), are also widely used for crop protection and have been reported to be linked to azole-resistant A. fumigatus (aR-Af) development in the environment. The aim of this study was to determine whether or not market gardens that spray DMIs in Eastern France are also affected by the presence of aR-Af. Forty aR-Afs were detected in soils in only two of the four market gardens using DMIs, with 23% (7/30) and 10% (3/30) of soils containing aR-Af. A total of 87.5% of these isolates had the TR34/L98H mutation and 22.5% the TR46/Y121F/T289A mutation on the cyp51A gene. Analyses of residual azole concentrations in soils showed the presence of difenoconazole for up to 2 years after spraying, but only in soils of market gardens where aR-Af was detected. It is very important to identify professional activities that could lead to aR-Af development and to develop preventive measures for at-risk patients living near professional activities using DMIs. We have to better understand why, in some cases, the use of DMI is not linked to aR-Af. Measures should be taken to avoid the use of DMI conferring cross-resistance to preserve the efficiency of human therapeutics.

https://ift.tt/2xhQDCG

Use of carbon-based composites to enhance performance of TiO 2 for the simultaneous removal of nitrates and organics from aqueous environments

Abstract

The simultaneous photocatalytic removal of nitrate from aqueous environment in presence of organic hole scavenger using TiO₂ has long been explored. However, the use of unmodified TiO₂ in such reaction resulted in non-performance or release of significant amount of undesirable reaction products in the process, a problem that triggered surface modification of TiO₂ for enhanced photocatalytic performance. Previous studies focused on decreasing rate of charge carrier recombination and absorption of light in the visible region. Yet, increasing active sites and adsorption capacity by combining TiO₂ with a high surface area adsorbent such as activated carbon (AC) remains unexploited. This study reports the potential of such modification in simultaneous removal of nitrates and oxalic acid in aqueous environment. The adsorptive behaviour of nitrate and oxalic acid on TiO₂ and TiO₂/AC composites were studied. The Langmuir adsorption coefficient for nitrate was four times greater than that of oxalic acid. However, the amount of oxalic acid adsorbed was about 10 times greater than the amount of nitrate taken up. Despite this advantage, the materials did not appear to produce more active photocatalysts for the simultaneous degradation of nitrate and oxalic acid. The photocatalytic activity of TiO₂ and its carbon-based composites was improved by combination with Cu₂O particles. Consequently, 2.5 Cu₂O/TiO₂ exhibited the maximum photocatalytic performance with 57.6 and 99.8% removal of nitrate and oxalic acid, respectively, while selectivity stood at 45.7, 12.4 and 41.9% for NH₄⁺, NO₂⁻ and N₂, respectively. For the carbon based, 2.5 Cu₂O/TiO₂-20AC showed removal of 12.7% nitrate and 80.3% oxalic acid and achieved 21.6, 0 and 78.4% selectivity for NH₄⁺, NO₂⁻ and N₂, respectively. Using the optimal AC loading (20 wt%) resulted in significant decrease in the selectivity for NH₄⁺ with no formation of NO₂⁻, which unveils that selectivity for N₂ and low/no selectivity for undesirable products can be manipulated by controlling the rate of consumption of oxalic acid. In contract, no nitrate reduction was observed with Cu₂O promoted TiO₂-T and its TiO₂-(T)-20AC, which may be connected to amorphous nature of TiO₂-T and perhaps served as charge carrier trapping sites that impeded activity.

https://ift.tt/2x8uTcT

Evidence for Multiparametric Magnetic Resonance Imaging as a Biomarker for Prostate Cancer Screening

This Viewpoint addresses whether there is sufficient evidence to support routine use of multiparametric magnetic resonance imaging as an adjunctive test for men with elevated prostate-specific antigen level and considers the practical implications of its widespread implementation.

https://ift.tt/2MqwnEg

Total Medicare Costs Associated With Diagnosis and Treatment of Prostate Cancer in Elderly Men

This large cohort study uses the SEER-Medicare database to evaluate the Medicare costs associated with diagnosis and treatment of nonmetastatic prostate cancer in men 70 years or older.

https://ift.tt/2QrqBW8

Oral Contraceptive Use and Increases in Breast, Ovarian, and Endometrial Cancers—Reply

In Reply We thank Dr Grant for the interest in our work. The associations between oral contraceptive (OC) use and the cancers on which we report have been established with extensive research; the protective effect of OC use on endometrial and ovarian cancer risk is well documented. Thus, the goal of our study was to evaluate the consistency of OC use–cancer risk associations across modifiable risk factors. The points raised about our article include potential confounding by (1) menopausal hormone therapy (MHT) use and (2) hysterectomy.

https://ift.tt/2MrBmVa

Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors

This systematic review and meta-analysis analyzes the incidence of regimen-specific fatal toxic effects associated with the use of immune checkpoint inhibitors for cancer treatment.

https://ift.tt/2NcqZK0

Oral Contraceptive Use and Increases in Breast, Ovarian, and Endometrial Cancers

To the Editor Michels and colleagues claim that long past oral contraceptive (OC) use reduces the risk of ovarian and endometrial cancer. Carcinogenic effects of more recent exposures to menopausal progestin and/or estrogen hormone therapy (HT) are ignored. Among the entire sample of women aged 50 to 71 years (median age, 60 years), 118 144 (60%) formed a control reference group that included both never users and women who had taken OCs for less than 1 year. Only 10% of women took OCs for at least 10 years. A follow-up 11 years later found that 18 199 women had cancer: 61% breast cancer, 19% colorectal cancer, 13% endometrial cancer, and 7% ovarian cancer.

https://ift.tt/2QxCTfQ

Atezolizumab Therapy for Patients With Metastatic Triple-Negative Breast Cancer

This phase 1 study evaluates the safety, clinical activity, and biomarkers associated with the use of single-agent atezolizumab in women with metastatic triple-negative breast cancer.

https://ift.tt/2Mv0z1f

A Lesion on the Scalp

A 67-year-old man presented with a rapidly enlarging, itchy scalp lesion without generalized pruritus first noticed 3 months earlier as a pimple. What is your diagnosis?

https://ift.tt/2QxCx90

Incorrect Author Surname

In the Brief Report titled "Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins," published online July 12, 2018, in JAMA Oncology,¹ the surname of one of the authors was incorrect. In the Article Information section, in the list of authors taking responsibility for the study as part of the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer, the full name of the author listed as Elisabete Weiderpass Vainio, MD, PhD, should have been given as Elisabete Weiderpass, MD, PhD. In addition, her affiliations should have been identified with the surname Weiderpass instead of Vainio (4 places), and her surname under "Critical revision of the manuscript for important intellectual content" in the Author Contributions section should have been listed as Weiderpass instead of Weiderpass Vainio. This article was corrected online.

https://ift.tt/2MsqDKj

Temperature and depth evaluation of the in vitro effects of femtosecond laser on oral soft tissue, with or without air-cooling

Abstract

Femtosecond laser is an effective and safe tool in many surgeries, but the studies of its effect on oral soft tissue ablation are insufficient. This study aimed to investigate the effect of soft tissue ablation with a 1030-nm femtosecond laser on temperature and depth. Twenty Sprague–Dawley rat tongue specimens were obtained and flat-mounted. The 1030-nm femtosecond laser was controlled by a computer system, with a set distance of 4.7 mm between the laser aperture and soft tissue surfaces. Ten specimens were ablated for > 1 min with or without air-cooling for temperature measurement, while the other 10 specimens were ablated for depth measurements, using the following parameters: (i) 3 W, 2000 mm/s; (ii) 3 W, 4000 mm/s; (iii) 5 W, 2000 mm/s; (iv) 5 W, 4000 mm/s; (v) 8 W, 2000 mm/s; (vi) 8 W, 4000 mm/s. Temperature changes were measured using a type-K thermocouple. The depth attained using different power and scanning speed settings was measured by a three-dimensional morphology measurement laser microscope. Laser power, scanning speed, and air-cooling effects were determined. Higher energy and lower speed induced higher temperatures (p < 0.05), which were significantly decreased by air-cooling (p < 0.05). The lowest ablation depth was obtained at 3 W and 4000 mm/s (72.63 ± 6.47 μm) (p < 0.05). The greatest incision depth was achieved at 8 W and 2000 mm/s (696.19 ± 35.37 μm), or 4000 mm/s (681.16 ± 55.65 μm) (p < 0.05). The 1030-nm femtosecond laser application demonstrates clinically acceptable ablation efficiency, without marked temperature damage, in a controlled manner.

https://ift.tt/2N6MzQh

Er,Cr:YSGG laser associated with acidulated phosphate fluoride gel (1.23% F) for prevention and control of dentin erosion progression

Abstract

To evaluate the effect of Er,Cr:YSGG laser, associated with fluoride application, on the prevention/control of dentin erosion. Dentin slabs were embedded in acrylic resin, flattened, and polished. Half of the specimens were previously eroded (10 min immersion in 1% citric acid solution) and half were kept sound. The specimens (n = 10 each substrate) were randomly allocated into the experimental groups, according to the following treatments: control (no treatment); APF gel (1.23% F, 1 min); Er,Cr:YSGG laser irradiation (P1: 0.25 W, 20 Hz, 2.8 J/cm², tip S75, beam diameter of 750 μm, 1 mm away from the surface); Er,Cr:YSGG laser irradiation (P2: 0.50 W, 20 Hz, 5.7 J/cm², tip S75, beam diameter of 750 μm, 1 mm away from the surface); APF gel + Er,Cr:YSGG laser P1 and; APF gel + Er,Cr:YSGG laser P2. Afterwards, the specimens underwent an erosion-remineralization cycling, consisting of a 5-min immersion into 0.3% citric acid, followed by 60-min exposure to artificial saliva. This procedure was repeated 4×/day, for 5 days. Surface loss (SL, in μm) was determined by optical profilometry. Specimens from each group were analyzed by environmental scanning electron microscopy (n = 3). Data were statistically analyzed (α = 0.05). For the eroded specimens, APF gel presented the lowest SL, being different from the control. For the sound specimens, none of the groups differed from the control, except for Er,Cr:YSGG laser P2, which presented the highest SL. When substrates were compared, only the eroded specimens of the control and APF + Er,Cr:YSGG laser P1 Groups showed higher SL. Selective structure removal was observed for the laser-treated groups. None of the Er,Cr:YSGG laser parameters were effective in the prevention/control dentin erosion. The laser was also unable to enhance the protection of fluoride against dentin erosion.

https://ift.tt/2Oi3tYP

Evaluation of theranostic perspective of gold-silica nanoshell for cancer nano-medicine: a numerical parametric study

Abstract

Using gold-silica nanoshell as a reference nano-agent, this work has performed preliminary numerical parametric study to investigate the feasibility and if feasible the efficiency of using a single nano-agent to achieve theranostic goals. In total, seven generics of gold-silica nanoshells have been tested including the R[50,10] (radius of the silica core is 50 nm and thickness of the gold shell is 10 nm), R[40,15], R[55,25], R[40,40], R[75,40], R[104,23], and R[154,24] nanoshells. A planar tissue model has been constructed as the platform for parametric study. For mathematical modeling, radiant transport equation (RTE) has been applied to describe the interactions among laser lights, the hosting tissue, and the hosted nanoshells and Penne's bio-heat equation has been applied to describe the hyperthermia induced by such interactions. Effects of different nanoshell generics on the diffuse reflectance signal and hyperthermia temperature transition have been simulated, basing on which the potential of a certain nanoshell generic as theranostic nano-agent has been evaluated. It has been found that it is highly feasible for gold-silica nanoshells to be engineered for theranostic purpose and nanoshell generics that are preferentially scattering should be explored for good theranostic candidates. On the condition that nanoshell generic with the right optical properties has been located, a moderate nanoshell retention in the target tissue site is already sufficient to induce effective theranostic effects, which indicates that theranostic nano-medicine might not have a stringent requirement for the delivery technique. Among nanoshells that have been tested, the R[55,25] nanoshell seems to be a promising candidate as theranostic nano-agent. Further testing on it is highly recommended. Nanoshells that are preferentially absorbing such as the R[50,10] and R[40,15] nanoshells are efficient photothermal agent and could be used for therapeutic purpose only. However, it is not recommended that preferentially absorbing nanoshells being used for theranostic purpose due to possible negative effects such nanoshells might bring to the diffuse reflectance signal.

https://ift.tt/2N8xMV7

Scholar : These new articles for Dynamics of Asymmetric Conflict are available online

The online platform for Taylor & Francis Online content New for Dynamics of Asymmetric Conflict and online now on Taylor & Francis Online: Articles Theology, heroism, justice, and fear: an analysis of ISIS propaganda magazines Dabiq and Rumiyah Tyler Welch Pages: 1-13 | DOI: 10.1080/17467586.2018.1517943 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Journal of the Institute of Conservation are available online

The online platform for Taylor & Francis Online content New for Journal of the Institute of Conservation and online now on Taylor & Francis Online: Articles Cast in a new light: surface topographies of Paul Gauguin's transfer drawings Mary E. Broadway, Harriet K. Stratis & Marc S. Walton Pages: 1-12 | DOI: 10.1080/19455224.2018.1509795 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

A Randomized Phase 2 Study of Cemiplimab ± ISA101b in HPV16-Positive OPC

Conditions:   Squamous Cell Carcinoma of the Oropharynx;   HPV16 Positive
Interventions:   Biological: ISA101b;   Drug: Cemiplimab;   Other: Placebo
Sponsors:   ISA Pharmaceuticals;   Regeneron Pharmaceuticals
Not yet recruiting

https://ift.tt/2x6QAu7

Pilot Study of Somatostatin Receptor Imaging in Nasopharyngeal Cancer

Condition:   Nasopharyngeal Carcinoma
Intervention:  
Sponsors:   National Cancer Centre, Singapore;   Singapore General Hospital;   A*Star
Recruiting

https://ift.tt/2D49jfl

To Study the Impact of Radiation Treatment After Surgery in Patient With Locally Advanced Thyroid Cancer.

Conditions:   Thyroid Cancer Stage IV;   Radiation Toxicity
Interventions:   Radiation: Intensity Modulated Radiotherapy;   Procedure: Surgery alone
Sponsors:   Tata Memorial Hospital;   Department of Atomic Energy
Recruiting

https://ift.tt/2x9VruB

Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma

Condition:   Nasopharyngeal Carcinoma
Interventions:   Radiation: Intensity-modulated radiation therapy;   Drug: Paclitaxel liposome;   Drug: Cisplatin;   Drug: 5-Fluorouracil
Sponsor:   Sun Yat-sen University
Not yet recruiting

https://ift.tt/2CPY4Hd

Overhauser DNP FFC study of block copolymer diluted solution

Publication date: Available online 12 September 2018

Source: Magnetic Resonance Imaging

Author(s): Bulat Gizatullin, Carlos Mattea, Siegfried Stapf

Abstract

Overhauser dynamic nuclear polarization (DNP) is the dominating hyperpolarization technique to increasing the nuclear magnetic resonance signal in liquids and diluted systems. The enhancement obtained depends on the overall mobility of the radical-carrying molecule but also on its specific interaction with the host molecules. Information about the nature of molecular and radical dynamics can be identified from determining the nuclear T₁ as a function of Larmor frequency by Fast Field Cycling (FFC) relaxometry. In this work, DNP and FFC methods were combined for a detailed study of ¹H Overhauser DNP enhancements at 340 mT (X-band) and 73 mT (S-band) for diluted solutions of a block-copolymer with and without the addition of TEMPO radicals. NMR relaxation dispersions of these solutions are measured at thermal polarization and DNP conditions in the X-band, and the obtained DNP data were analyzed by a model of electron-nucleus interactions modulated by translational diffusion. The coupling factors for the two different blocks of the copolymer are obtained independently from DNP and NMRD experiments. An additional contribution from scalar interactions was found for polystyrene blocks.

https://ift.tt/2NF0tbD

Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ

Insights into the In Vivo Role of Ifi35 in Promoting H5N1 Influenza and Neurotropic Vesicular Stomatitis Virus Disease

AP Gounder - 2018

The mammalian innate immune system is uniquely poised to respond to microbial
insults and act as our first line of defense. Proper control of viral infection depends on
the induction of interferon (IFN) and a multitude of interferon stimulated genes (ISGs) …

Everolimus plus endocrine vs endocrine therapy in treatment advanced ER+, HER2− breast cancer patients: A meta-analysis

N Wang, K Wang, Y Liu, F Song - Current Problems in Cancer, 2018

… Most frequently reported adverse events associated with everolimus treatment were
stomatitis, rash, fatigue, diarrhea, decreased appetite, cough, dyspnea, and pneumonitis …
Stomatitis, 0, 0.61, RR(fixed effects model), 4.98[3.89,6.36], 12.8(P < 0.00001) …

Practice update: Cancer in the community Part 2: Supportive care for the oncology patient

G Gaughran, A Body - AJP: The Australian Journal of Pharmacy, 2018

… Stomatitis is essentially mucositis of the perioral/oral cavity but related to non-
chemotherapeutic agents. The classic example we encounter in the clinical setting is
everolimus (a drug used in breast and renal cancer)-induced stomatitis …

Terminal ileac ulcers mimicked post-transplantation lymphoproliferative disorder in a heart recipient treated with everolimus: A case report

K Iwasaki, O Seguchi, H Mochizuki, Y Kimura, K Toda… - Transplantation …, 2018

… Although oral mucositis and stomatitis occurred soon after EVL initiation, no other adverse
events occurred … Various adverse reactions of EVL are known to affect several organ
systems [11-12], and mucositis and stomatitis are common in the gastrointestinal tract …

[HTML] Vitamin D Deficiency and Graft-Versus-Host Disease in Hematopoietic Stem Cell Transplant Population

A Arain - Hematology/Oncology and Stem Cell Therapy, 2018

… incidence of chemotherapy-induced toxicity has not been widely
studied.[45] A case report by Fink et al.[46] mentioned the case of a
59-year-old female with history of breast cancer, receiving chemotherapy …

Role of APOL1 in Human Parietal Epithelial Cell Transition

V Kumar, H Vashistha, X Lan, N Chandel, K Ayasolla… - The American Journal of …, 2018

… The same construct has been used to generate HIV transgenic mice (Tg26) 25, 26. This
parental construct (pNL4-3: ΔG/P- GFP) was used to produce vesicular stomatitis virus
G-pseudotyped viruses to provide pleiotropism and high titer virus stocks …

[PDF] The Effect of Immersed Heat Cured Acrylic Resin Denture Base in Clorhexidin and Extract of Roselle Flower towards Color Stability

M Zulkarnain, P Angelyna - 2018

… When the denture is not cleaned properly, it will cause unpleasant odor,
accumulation of calculus and denture stomatitis [5]. The most common way
used to clean denture is by immersing denture into chemical liquid that …

Treatment effectiveness and tolerability of afatinib at different doses in patients with EGFR-mutated lung adenocarcinoma: How low can we go?

CK Lim, YF Wei, MS Tsai, KY Chen, JY Shih, CJ Yu - European Journal of Cancer, 2018

… Dermatological adverse effects including skin rash, acne, paronychia,
stomatitis and mucositis were commonly encountered in patients during
afatinib therapy [7], [8]. It was difficult to analyse the dermatological …

Aloe vera waste biomass-based adsorbents for the removal of aquatic pollutants: A review

DA Giannakoudakis, A Hosseini-Bandegharaei… - Journal of Environmental …, 2018

… Other conditions that Aloe vera showed beneficial results include lichen planus,
aphthous stomatitis, oral submucous fibrosis, pulpotomy of primary teeth,
prevention of dry sockets, obturation of primary teeth, disinfection of irrigation …

[PDF] Impact of KIR and HLA genotypes on the outcome and susceptibility to Ebola virus disease

V Lhermitte, GAB Tech - 2018

… Probability value REBOV Reston ebolavirus RNA Ribonucleic acid RT-PCR Reverse
Transcription Polymerase Chain Reaction rVSV-ZEBOV Recombinant Vesicular Stomatitis
Virus Zaire Ebolavirus s Second SEBOV Sudan ebolavirus sGP Small Glycoprotein …

 

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Scholar : Obstructive sleep apnea - νέα αποτελέσματα

Discerning Depressive Symptoms in Patients with Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy on Hamilton Depression …

RS Bucks, S Nanthakumar, SS Starkstein, D Hillman… - Sleep, 2018

The assessment of depression in obstructive sleep apnea (OSA) is confounded by
the overlap in symptoms between the disorders. However, previous analysis by our
group has suggested that while some depressive symptoms tend to overlap with …

[PDF] Pulmonary Hypertension is Associated with Increased Mortality and Readmission in Patients with Obstructive Sleep Apnea Admitted for Heart Failure Exacerbation

CN McQuade, AD Althouse, JS Prince, AJ Sommerfeld… - Journal of Cardiac Failure, 2018

Background Pulmonary hypertension (PH) is common among patients with heart
failure (HF) and obstructive sleep apnea (OSA) but little data exists regarding how it
influences readmission and mortality Objectives We assessed the hypothesis that the …

Cardiovascular endpoints for obstructive sleep apnea with twelfth cranial nerve stimulation (CARDIOSA‐12): Rationale and methods

RC Dedhia, AA Quyyumi, J Park, AJ Shah, PJ Strollo… - The Laryngoscope, 2018

Objectives/Hypothesis To determine the effect of therapeutic levels of hypoglossal
nerve stimulation therapy (HGNS), compared to subtherapeutic levels of HGNS, on
24‐hour ambulatory blood pressure, sympathetic activity, and vascular function …

Sleep apnea valve harness device

E Nussbaum, C Kramer - US Patent App. 15/960,258, 2018

… Such devices fail to effectively address the issues of sleep apnea. Chronic
Obstructive Pulmonary Disease (COPD) includes chronic bronchitis,
emphysema and asthma. In both chronic bronchitis and emphysema, air …

The Balance of Sleep: Role of the Vestibular Sensory System

S Besnard, B Tighilet, C Chabbert, M Hitier, J Toulouse… - Sleep Medicine Reviews, 2018

… In the context of obstructive sleep apnea syndrome (OSAS), there is a dearth of literature …
It originates from oropharyngeal alterations which cause a decrease of genioglossal tone
during sleep, inducing repetitive obstruction of the upper airway during inspiration …

[PDF] Diabetes is Associated with Worse In-Hospital and 30-Day Post-Discharge Morbidity in Patients with Heart Failure with Preserved Ejection Fraction: Findings from the …

K McHugh, JJ Wu, RA Matsouaka, AD DeVore… - Journal of Cardiac Failure, 2018

… 246 Pulmonary Hypertension is Associated with Increased Mortality and
Readmission in Patients with Obstructive Sleep Apnea Admitted for Heart
Failure Exacerbation Casey N. McQuade1, Andrew D. Althouse1, Jennifer …

[HTML] Dexmedetomidine added to propofol for drug-induced sleep endoscopy in adult patients with obstructive sleep apnea: Randomized controlled trial

EF Abdelgalel - Egyptian Journal of Anaesthesia, 2018

Background The aim of this study was to evaluate if the addition of dexmedetomidine
to propofol could improve the success and reduce the complications during drug
induced sleep endoscopy in obstructive sleep apnea patients. Patient and methods …

[PDF] Noninvasive Remote Dielectric Sensing Vest Significantly Reduces Readmission Rate of Patients with Heart Failure

S Roy, A Zafar, CE Vazquez, NA Biniwale, QJ Tong… - Journal of Cardiac Failure, 2018

… 246 Pulmonary Hypertension is Associated with Increased Mortality and
Readmission in Patients with Obstructive Sleep Apnea Admitted for Heart
Failure Exacerbation Casey N. McQuade1, Andrew D. Althouse1, Jennifer …

Accommodating Research in Busy Bariatric Practice

AL Wiegmann, A Torquati - Global Bariatric Surgery, 2018

… It is also important to offer certain services relevant to the treatment of certain obesity
comorbidities, such as offering a sleep study lab for the diagnosis of obstructive sleep
apnea (OSA) that a large cohort of obese patients will suffer from …

The Super Super-Obese

KD Higa, AC Wittgrove - Global Bariatric Surgery, 2018

… 2 . This is relevant as individuals with higher BMIs are more likely to have
more complex health issues such as obstructive sleep apnea, metabolic
syndrome, and hepatic steatosis which are associated with higher surgical …

 

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