Ετικέτες

Πέμπτη 8 Νοεμβρίου 2018

Caries detection enhancement using texture feature maps of intraoral radiographs

Abstract

Objectives

Dental caries are caused by tooth demineralization due to bacterial plaque formation. However, the resulting lesions are often discrete and thus barely recognizable in intraoral radiography images. Therefore, more advanced detection techniques are in great demand among dentists and radiographers. This study was performed to evaluate the performance of texture feature maps in the recognition of discrete demineralization related to caries plaque formation.

Methods

Digital intraoral radiology image analysis protocols incorporating first-order features (FOF), co-occurrence matrices, gray tone difference matrices, run-length matrices (RLM), local binary patterns (LBP), and k-means clustering (CLU) were used to transform the digital intraoral radiology images of 10 patients with confirmed caries, which were retrospectively reviewed in a dental clinic. The performance of the resulting texture feature maps was compared with that of radiographic images by radiologists and dental specialists.

Results

Significantly improved detection of caries spots was achieved by employing the CLU and FOF texture feature maps. The caries-affected area with sharp margins was well defined using the CLU approach. A pseudo-three-dimensional effect was observed in outlining the demineralization zones inside the cavity with the FOF 5 protocol. In contrast, the LBP and RLM techniques produced less satisfactory results with unsharp edges and less detailed depiction of the lesions.

Conclusions

This study illustrated the applicability of texture feature maps to the recognition of demineralized spots on the tooth surface debilitated by caries and identified the best performing techniques.



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Poultry biogas slurry can partially substitute for mineral fertilizers in hydroponic lettuce production

Abstract

Poultry biogas slurry, a by-product of the biogas production process, is rich in nutrients. However, improper handling increases the potential for serious environmental contamination and resource waste. The preparation of nutrient solutions for hydroponic lettuce production requires large amounts of mineral fertilizers, which provides an opportunity for poultry biogas slurry to enter the crop nutrient cycle. To assess the feasibility of the application of poultry biogas slurry, we used different proportions of biogas slurry and mineral fertilizers in a hydroponics experiment with lettuce. Four treatments were established: HS (half-strength Hoagland solution), BS (2.6% biogas slurry), BS + HS (1.3% biogas slurry + quarter-strength Hoagland solution), and BS + MF (2.6% biogas slurry + mineral fertilizers). The addition of poultry biogas slurry (BS + HS) did not have an adverse effect on lettuce growth, significantly increased the soluble sugar concentration, reduced the nitrate concentration, and the concentrations of heavy metals were still within the safety standards. In addition, the application of poultry biogas slurry could effectively reduce the production costs, energy consumption, and greenhouse gas emissions of hydroponically grown lettuce. Based on our study, poultry biogas slurry could replace 50% of the mineral fertilizer used in hydroponic lettuce production. The key is to control the electrical conductivity and replenish the nutrients that are lacking in the biogas slurry, especially magnesium.



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Prevalence of nasal colonization by methicillin-resistant Staphylococcus aureus in outpatients living with HIV/AIDS in a Referential Hospital of the Northeast of Brazil.

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Prevalence of nasal colonization by methicillin-resistant Staphylococcus aureus in outpatients living with HIV/AIDS in a Referential Hospital of the Northeast of Brazil.

BMC Res Notes. 2018 Nov 06;11(1):794

Authors: Regina Pedrosa Soares C, de Lira CR, Cunha MAH, Romão de Souza Junior V, Lopes de Melo F, de Araújo PSR, Maciel MAV

Abstract
OBJECTIVE: The purpose of this study is to investigate the prevalence of MRSA among people living with HIV/AIDS (PLHA) being monitored in a tertiary outpatient hospital in the state of Pernambuco, in the Brazilian Northeast.
RESULTS: Staphylococcus aureus was isolated from a nasal swab and found in 31.4% of the individuals (95% CI 27.3-35.5), of whom 4.4% (95% CI 8.5-19.5) were MRSA, as confirmed by the presence of the mecA gene. For individuals whose S. aureus was recovered, the mean age was 41.5 years; 93.6% were on antiretroviral treatment. This group had CD4 cell counts > 200 (92%) and viral load ≤ 100 copies (79.1%). Use of antimicrobial agents in the past 12 months was found among 21% of the individuals, and 24.2% reported use of illicit drugs at lease once in their lifetime. Prevalence of nasal colonization by MSSA (26.7%) and MRSA (4.4%) was higher in comparison to other studies of this population; nevertheless, we were unable to establish factors associated with risk.

PMID: 30400979 [PubMed - in process]



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Contaminated sites, waste management, and green chemistry: new challenges from monitoring to remediation



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Multi-material Three-Dimensional Food Printing with Simultaneous Infrared Cooking

3D Printing and Additive Manufacturing, Ahead of Print.


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Relevance of Reference Centers in Sarcoma Care and Quality Item Evaluation: Results from the Prospective Registry of the Spanish Group for Research in Sarcoma (GEIS)

AbstractBackground.Reference centers (RCs) are a key point for improving the survival of patients with soft‐tissue sarcomas (STS). The aim of this study was to evaluate selected items in the management of patients with STS, comparing results between RC and local hospitals (LHs).Materials and Methods.Diagnostic and therapeutic data from patients diagnosed between January 2004 and December 2011 were collected. Correlation with outcome was performed.Results.A total of 622 sarcomas were analyzed, with a median follow‐up of 40 months. Imaging of primary tumor preoperatively (yes vs. no) correlated with a higher probability of free surgical margins (77.4% versus 53.7%; p = .006). The provenance of the biopsy (RC vs. LH) significantly affected relapse‐free survival (RFS; 3‐year RFS 66% vs. 46%, respectively; p = .019). Likewise, 3‐year RFS was significantly worse in cases with infiltrated (55.6%) or unknown (43.4%) microscopic surgical margins compared with free margins (63.6%; p < .001). Patients managed by RCs had a better 3‐year overall survival compared with those managed by LHs (82% vs. 70.4%, respectively; p = .003). Perioperative chemotherapy in high‐risk STS, more frequently administered in RCs than in LHs, resulted in significantly better 3‐year RFS (66% vs. 44%; p = .011). In addition, patients with stage IV disease treated in RCs survived significantly longer compared with those in LHs (30.4 months vs. 18.5 months; p = .036).Conclusion.Our series indicate that selected quality‐of‐care items were accomplished better by RCs over LHs, all with significant prognostic value in patients with STS. Early referral to an RC should be mandatory if the aim is to improve the survival of patients with STS.Implications for Practice.This prospective study in patients diagnosed with soft‐tissue sarcoma shows the prognostic impact of reference centers in the management of these patients. The magnitude of this impact encompasses all steps of the process, from the initial management (performing diagnostic biopsy) to the advanced disease setting. This is the first prospective evidence showing improvement in outcomes of patients with metastatic disease when they are managed in centers with expertise. This study provides extra data supporting referral of patients with sarcoma to reference centers.

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Age and the Risk of Paclitaxel‐Induced Neuropathy in Women with Early‐Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101

AbstractPurpose.A few previous studies report a direct relationship between older age and chemotherapy‐induced neuropathy. This study further evaluated this adverse event's age‐based risk.Methods.CALGB 40101 investigated adjuvant paclitaxel (80 mg/m2 once per week or 175 mg/m2 every 2 weeks) in patients with breast cancer and served as a platform for the current study that investigated age‐based differences in neuropathy. Grade 2 or worse neuropathy, as per Common Terminology Criteria for Adverse Events version 4, was the primary endpoint; patients were assessed at baseline, every 6 months for 2 years, and then annually for 15 years.Results.Among these 1,881 patients, 230 were 65 years of age or older, 556 were 55–64 years, and 1,095 were younger than 55; 1,226 neuropathy events (commonly grade 1 or 2) were reported in 65% of the cohort. The number of grade 2 or worse events was 63 (27%), 155 (28%), and 266 (24%) within respective age groups (p = .14). In univariate analysis, only motor neuropathy had a higher age‐based incidence: 19 (8%), 43 (8%), and 60 (5%), respectively (p = .04); in multivariate analyses, this association was no longer statistically significant. Other endpoints, such as time to onset of neuropathy (time from trial enrollment to neuropathy development) and time to improvement (time from maximal grade sensory neuropathy to a one‐category improvement), showed no statistically significant age‐based differences. In contrast, obesity was associated with neuropathy, and every 2‐week paclitaxel was associated with trends toward neuropathy.Conclusion.Although paclitaxel‐induced neuropathy is common, older age is not an independent risk factor. Clinical trial identification number. NCT00041119 (CALGB 40101).Implications for Practice.Age alone is not an independent risk factor for paclitaxel‐induced neuropathy.

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Hydroxychloroquine sulphate therapy of erosive oral lichen planus

Abstract

Background/Objectives

Erosive oral lichen planus (LP) may be painful and debilitating. Symptomatic oral LP has been treated with a wide spectrum of topical and systemic therapies, but few have been evaluated in large series. Hydroxychloroquine is suggested to be effective in oral LP.

Methods

Twenty‐one consecutive patients with erosive, biopsy‐confirmed oral LP were prescribed. hydroxychloroquine sulphate 400 mg/day. Symptomatic improvement was evaluated by means of a visual analogue scale into three groups: no change, moderate to marked improvement and complete remission.

Results

Five (24%) patients obtained complete remission, 12 (57%) patients showed moderate to marked improvement, 3 (14%) patients did not improve at all and in one patient therapy was terminated after 1 month due to side effects. Response to therapy was observed after 2–4 months. Side effects which ultimately led to termination of therapy in three patients were elevated creatinine serum levels (after 1 month), visual field defects (after 8 months) and hyperpigmentation (after 24 months). Among six patients who responded to therapy, three flared on stopping.

Conclusions

Hydroxychloroquine sulphate may be effective and relatively safe treatment for erosive oral LP.



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Efficacy of erbium glass laser in the treatment of Old World cutaneous leishmaniasis: A case series

Abstract

Background

Treatment of cutaneous leishmaniasis remains a challenge; new physical treatment modalities including laser systems are of interest in the treatment of localized lesions.

Method

Fourteen patients (10 females) with 20 lesions of Old World cutaneous leishmaniasis underwent weekly treatments of 1540 nm erbium glass fractional laser (Palomar) using 10 mm spot size hand piece in four passes of 50–70 mJ/cm2 fluence and 10 ms pulse duration.

Results

Twelve lesions were available for assessment: six (50%) improved at 6 weeks and eleven lesions (91.7%) at 12 weeks. There were no recurrences at 6‐ and 12‐month follow‐ups.

Conclusion

Erbium glass fractional laser may be an alternative treatment for localized cases of Old World cutaneous leishmaniasis.



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Comparative on plant stoichiometry response to agricultural non-point source pollution in different types of ecological ditches

Abstract

Long-term agricultural development has led to agricultural non-point source (NPS) pollution. Ecological ditches (eco-ditch), as specific wetland systems, can be used to manage agricultural NPS water and achieve both ecological and environmental benefits. In order to understand which type of eco-ditch systems (Es, soil eco-ditch; Ec, concrete eco-ditch; Eh, concrete eco-ditch with holes on double-sided wall) is more suitable for plant nutrient balance meanwhile reducing NPS water (total nitrogen [TN], about 10 mg/L; total phosphorus [TP], about 1 mg/L), it is essential to evaluate the plant (Vallisneria natans) stoichiometry response to water in different types of eco-ditches under static experiment. The results indicated that there were no significant differences in TP removal efficiency among three eco-ditches, yet Eh systems had the best TN removal efficiency during the earlier experimental time. Addition of agricultural NPS water had varying effects on plants living in different types of eco-ditch systems. Plant organ stoichiometry of V. natans varied in relation to eco-ditch types. Plant stoichiometry (C:N, C:P, and N:P) of V. natans in Eh systems could maintain the homeostasis of nutrients and was not greatly affected by external changing environment. V. natans in Es systems can more easily modify the nutrient contents of organs with regard to nutrient availability in the environment. Our findings provide useful plant stoichiometry information for ecologists studying other specific ecosystems.



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Early risk factors for cow's milk allergy in children in the first year of life



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Extrinsic warming of low-osmolality iodinated contrast media to 37°C reduced the rate of allergic-like reaction



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Effect of indoor air quality on the natural history of asthma in an urban population in Poland



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Effect of indoor air quality on the development of rhinitis in an urban population in Poland



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Atopic dermatitis: A disease “More common in families that sneeze and wheeze”



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The burden of atopic dermatitis



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Severe atopic dermatitis: Therapeutic update



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The effect of preoperative penicillin allergy testing on perioperative non‐beta-lactam antibiotic use: A systematic review and meta-analysis



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Cross-sectional study on Asthma Insights and Management in the Gulf and Russia



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Impact of patient satisfaction with his or her inhaler on adherence and asthma control

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Assessment of atopic dermatitis as a risk factor for chronic spontaneous urticaria in a pediatric population



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Challenges in managing patients referred for eosinophilic esophagitis: A telephone survey and retrospective review



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Correlation of negative skin-prick test results for tree nuts and successful tree nut challenges among children with peanut allergy



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Human factors engineering validation study for a novel 0.1-mg epinephrine auto-injector



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Pearls and pitfalls in the diagnosis of cough variant asthma



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Generalized rash and pruritus in a 58-year-old woman



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For the Patient



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Effect of indoor air quality on the development of rhinitis in an urban population in Poland



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The risk of neurodegeneration in REM Sleep Behavior Disorder: A systematic review and meta-analysis of longitudinal studies

Several studies report an association between REM Sleep Behavior Disorder (RBD) and neurodegenerative diseases, in particular synucleinopathies. Interestingly, the onset of RBD precedes the development of neurodegeneration by several years. This review and meta-analysis aims to establish the rate of conversion of RBD into neurodegenerative diseases. Longitudinal studies were searched from the PubMed, Web of Science, and SCOPUS databases. Using random-effect modeling, we performed a meta-analysis on the rate of RBD conversions into neurodegeneration.

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Neurobiological and Immunogenetic Aspects of Narcolepsy: Implications for Pharmacotherapy

Excessive daytime sleepiness (EDS) and cataplexy are common symptoms of narcolepsy, a sleep disorder associated with the loss of hypocretin/orexin (Hcrt) neurons. Although only a few drugs have received regulatory approval for narcolepsy to date, treatment involves diverse medications that affect multiple biochemical targets and neural circuits. Clinical trials have demonstrated efficacy for the following classes of drugs as narcolepsy treatments: alerting medications (amphetamine, methylphenidate, modafinil/armodafinil, solriamfetol [JZP-110]), antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors), sodium oxybate, and the H3-receptor inverse agonist/antagonist pitolisant.

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Methylococcaceae are the dominant active aerobic methanotrophs in a Chinese tidal marsh

Abstract

Although coastal marshes are net carbon sinks, they are net methane sources. Aerobic methanotrophs in coastal marsh soils are important methane consumers, but their activity and populations are poorly characterized. DNA stable-isotope probing followed by sequencing was used to determine how active methanotrophic populations differed in the main habitats of a Chinese coastal marsh. These habitats included mudflat, native plant-dominated, and alien plant-dominated habitats. Methylococcaceae was the most active methanotroph family across four habitats. Abundant methylotroph sequences, including methanotrophs and non-methane-oxidizing methylotrophs (Methylotenera and Methylophaga), constituted 50–70% of the 16S rRNA genes detected in the labeled native plant-dominated and mudflat soils. Methylotrophs were less abundant (~ 20%) in labeled alien plant-dominated soil, suggesting less methane assimilation into the target community or a different extent of carbon cross-feeding. Canonical correspondence analysis indicated a significant correlation between the active bacterial communities and soil properties (salinity, organic carbon, total nitrogen, pH, and available phosphorus). Importantly, these results highlight how changing vegetation or soil features in coastal marshes may change their resident active methanotrophic populations, which will further influence methane cycling.



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Growth and biochemical changes in quail bush ( Atriplex lentiformis (Torr.) S.Wats) under Cd stress

Abstract

Halophytes have several advantages to be more effective in metal phytoextraction. Little is known about the Cd-phytoextraction potential of Atriplex lentiformis under different levels of Cd. Seven levels of Cd (0, 40, 80, 120, 160, 200, and 240 mg per kg of soil) were added to A. lentiformis plants grown on pots filled with 5 kg of sandy loam soil. A. lentiformis plants achieve different defense mechanisms to meet the high concentration of Cd in the soil and plant. These mechanisms include reducing the number and area of leaves, minimizing chlorophyll synthesis, and enhancing synthesizing of oxalic acid, phenols, and proline. The critical point of Cd was 9.35 and 183 mg kg−1 for available soil Cd and leaves concentrations, respectively. The maximum level of Cd displayed a 66% decrease in the chlorophyll content of the leaves. On the other hand, the oxalic acid, phenols, and proline in the leaves were increased significantly by 129, 100, and 200% when Cd increased from 0 to 240 mg. The tested plant removed 3.6% of the total soil Cd under the low Cd concentration (40 mg) but under the high level of Cd (240 mg), it only removed a negligible amount of soil Cd (0.74%). The current study confirmed that A. lentiformis plants lost the ability to cleanup Cd from contaminated soil under the high levels of contamination due to the high reduction in the production of dry matter.



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Early adiposity rebound in patients with Prader-Willi syndrome

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


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Sub-lethal effects induced by a mixture of different pharmaceutical drugs in predicted environmentally relevant concentrations on Lithobates catesbeianus (Shaw, 1802) (Anura, ranidae) tadpoles

Abstract

The increasing consumption of medications by humans has negative effects such as the increased disposal of these compounds in the environment. Little is known about how the disposal of a "drug mix" (DM) in aquatic ecosystems can affect their biota. Thus, we evaluated whether the exposure of Lithobates casteibeianus tadpoles to a DM composed of different medication classes (antibiotic, anti-inflammatory, antidepressant, anxiolytic, analgesic, and antacid drugs)—at environmentally relevant concentrations—may change their oral morphology, trigger behavioral disorders, and have mutagenic effects on erythrocyte cells. Based on our data, animals exposed to the DM showed changes in mandibular sheath pigmentation, dentition, and swimming activity, as well as atypical behavior in the social aggregation test [with co-specific and interspecific (Physalaemus cuvieri) individuals] and antipredatory defensive response deficit (chemical stimulus from Odonata larvae), after 15 exposure days. The mutagenic analysis revealed higher frequency of nuclear abnormalities in the erythrocytes of tadpoles exposed to the DM (e.g., multilobulated, blebbed, kidney-shaped, notched nucleus, binuclear, and micronucleated erythrocytes). Given the chemical complexity of the DM, we assumed that several organic functions may have been affected, either by the isolated, synergistic, antagonistic, or additive action of DM compounds. Finally, our study confirms the toxicological potential of DM in L. catesbeianus tadpoles, with emphasis to impacts that can affect the fitness of individuals and their natural populations. Thus, we suggest that more attention should be given to the disposal of medications in the environment and reinforce the need of improving water and sewage treatment systems.



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Transformation of cadmium-associated schwertmannite and subsequent element repartitioning behaviors

Abstract

Schwertmannite is an important sink for cadmium (Cd) in acid mine drainage (AMD) environments and is unstable when environmental conditions change. However, the release and redistribution of Cd during schwertmannite transformation with respect to pre-bound Cd are poorly understood. In this work, the transformation of cadmium-associated schwertmannite and subsequent Cd repartitioning behaviors were investigated. The way of schwertmannite associated with Cd was predominant by absorption, and the diffuse layer model (DLM) showed that Cd2+ existed as monodentate complexes ≡Fe(1)OCd+ and ≡Fe(2)OCd+ on schwertmannite surfaces. Kinetics of SO42− release and mineralogical characterization both showed that the mineral transformation rates decreased and more lepidocrocite aggregated with increasing adsorbed Cd levels. The shrinking core model revealed that Fe(II)-induced process would affect mineral dissolution by changing surface reaction-controlled step to internal diffusion-controlled step, and significantly promote the dissolution rate of Cd-adsorbed schwertmannite. Adsorbed Cd blocked the surface sites for later Fe(II) adsorption and the Fe(II)-Fe(III) electron transfer, then resulted in the decelerated transformation and the accumulation of intermediate phase lepidocrocite. The maximum release of aqueous Cd occurred after 1 mM Fe2+ addition, then over 69% of initial added Cd(aq) re-bound to solid-phase accompanying with mineral transformation, and finally, Cd was mainly associated with the secondary minerals by complexation with surficial OH groups. These findings are useful for developing the strategies for treating Cd contamination in AMD affected areas.



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Additive Chemotherapie mit Cisplatin und Gemcitabin nach kurativ intendierter Radiochemotherapie verbessert das rezidivfreie Überleben von Nasopharynxkarzinompatienten mit noch nachzuweisender EBV-DNA-Last nicht



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Efficiency of sequential UV/H 2 O 2 and biofilm process for the treatment of secondary effluent

Abstract

In response to the shortage of water resources, multiple processes have been applied to turn wastewater secondary effluent (SE) into potable water. However, trace organic contaminants (TOrCs) and high concentrations of organic matter contained in SE pose a significant challenge to the reclamation. In this manuscript, combined UV-based and biofilm processes were used to treat the SE spiked with ibuprofen (IBU) and clofibric acid (CA). The efficiency of these sequential treatments was characterized in terms of changes in dissolved organic carbon (DOC), absorbance at 254 nm (A254), fluorescence excitation-emission matrix (FEEM), the concentration of IBU and CA, and molecular weight of SE. Parallel factor (PARAFAC) was applied as the analysis method for FEEM of the samples and two fluorescent components were successfully identified: humic-like substances (C1) and protein-like matter (C2). Large reductions in A254, C1, C2, IBU, and CA were observed during the UV-based processes, especially with the addition of H2O2. Nearly 50% of A254, 80% of the component C1 were decreased and almost complete removal of the component C2 and TOrCs was achieved by UV/2.0 mM H2O2 after 90-min treatment. During the oxidation processes, the formation of lower molecular weight (LMW) compounds was detected, and the biodegradability of the organic matters was greatly increased. Although no significant DOC reduction was obtained in UV-based processes, an obvious further DOC reduction (30~60%) was achieved by biofilm treatment following UV-based processes, especially after UV/H2O2 treatments. In the meantime, large amounts of LMW were removed in the biofilm treatment process. This manuscript provides an effective advanced treatment of SE for the removal of DOC and TOrCs, facilitating the wastewater reclamation.



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The use of biochar and crushed mortar in treatment wetlands to enhance the removal of nutrients from sewage

Abstract

An experimental study was carried out using in pilot-scale constructed wetland systems, operated in parallel to treat raw sewage. Each system consisted of a vertical flow (VF) unit that was filled with biochar as the main media, followed by a horizontal flow (HF) unit filled with crushed cement mortar. Hydraulic loading (HL) ranged 340–680 mm/day was applied on the VF wetland units, where high total nitrogen (TN) mass removal rate (20–23 g N/m2 d) was obtained, demonstrating that biochar media had a beneficial effect on the degradation of nitrogenous pollutants. Total phosphorus (TP) removal percentage (concentration based) was ≥ 86% in HF wetlands packed with mortar materials. In one system, the flow direction of the sewage was directed by the deployment of downflow pipes and vertical baffles, aiming to facilitate the formation of aerobic and anaerobic zones in the wetland matrices. The effects of such arrangement were analyzed by comparing pollutant removal efficiencies in the two systems. On average, 99, 96, 93, and 86 percentage removals were obtained for ammonia (NH4-N), TN, biochemical oxygen demand (BOD), and TP, respectively, during the experiments. Biochar and crushed mortar proved to be a highly effective combination as media in subsurface flow constructed wetlands for wastewater treatment.



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Sludge nematodes, cestodes, and trematodes eggs variation from lagooning, activated sludge and infiltration-percolation wastewater treatment system under semi-arid climate

Abstract

The prevalence and the identification of the helminth eggs load of raw sewage sludge was assessed of three different wastewater treatment systems. The results showed a variety of parasite species with following average concentrations; five taxa belonging to three classes nematodes, cestodes and trematodes were inventoried. The class of nematodes is the most diverse with 5 taxa. It is represented by the eggs of Ascaris sp., Capillaria sp., Trichuris sp., Toxocara sp., and Ankylostome sp., then comes the cestodes class, this is represented by the eggs of Tænia sp. The trematode class is represented by Schistosoma sp. The lagooning station of Chichaoua shows the highest load 7 species with Ascaris 21 eggs/g; Capillaria sp., 11 eggs/g; Trichuris sp., 6 eggs/g; Toxocara sp., 2 eggs/g and Ankylostome sp., 1 egg/g; Taenia sp., 2eggs/g; and Schistosoma sp., 1 egg/g. Infiltration-percolation sludge show the presence of 4 species of helminths eggs in sludge from anaerobic settling with different rates: 15 eggs/g for Ascaris sp., 15 eggs/g for Trichuris sp., 13 eggs/g for Capillaria sp., and 8 eggs/g for Taenia sp. However, in sand filter pool, the sludge helminth eggs load was decreased by 47% of Ascaris sp., 85% of Capillaria sp., and 75% of Taenia sp., Nevertheless, an increase of Trichuris eggs load was noted in the second sludge by 17%. Five helminth eggs was detected in primary sludge coming from decantation pools in activated sludge plant in Marrakech, that is Ascaris sp., with a load of 16 eggs/g; Capillaria sp., with 3 eggs/g, Trichuris eggs with 2 eggs/g; Taenia sp., with 4 eggs/g; and Schistosoma sp., with 2 eggs/g. The abatement load of Ascaris sp. with 81% and Schistosoma and Taenia sp., with 100% was noted in biological sludge. Nevertheless, an increase load of Capillaria and Trichuris eggs 81% and 75% respectively was observed in this sludge coming from biological pools. The distribution of parasitic helminth eggs is linked to the differences in demographic and socio-economic status, seasonal variation, physico-chemical characteristic of helminth eggs, and the purification wastewater system performance.



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Moving Precision Oncology Forward Amid Myths and Misconceptions—Reply

In Reply We are grateful for the broad interest in our article. In our study, we sought to estimate the percentage of US patients with cancer who are eligible for and may benefit from US Food and Drug Administration (FDA)–approved genome-driven cancer therapies, assuming universal testing and access to these therapies. We found that, as of 2018, the percentage of patients eligible for genome-directed therapies was 8.33%, and the percentage of patients benefiting (ie, those whose response may be attributed to the drug) was 4.90%. These percentages increased linearly at approximately 0.5% annually between 2006 and 2018 (as shown in eFigure 1 in the Supplement of our study). We emphasized the need to pursue research on genomic treatment alongside broader therapeutic strategies, such as immunotherapy and cytotoxic drugs.

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Moving Precision Oncology Forward Amid Myths and Misconceptions

To the Editor In the article by Marquart et al, the proportion of patients with advanced cancers eligible for and benefiting from US Food and Drug Administration–approved genome-driven treatments between 2006 and 2018 is estimated. A key finding is that such strategies would only benefit 6.62% of patients in 2018. These results need to be interpreted with caution, especially because they are approximated using multiple retrospective data assumptions and sensitivity analyses that do not consider key clinical trial details. For example, the 16% response rate of trastuzumab was based on a trial that included 23% of patients with moderate (2+) human epidermal growth factor receptor 2 (ERBB2/HER2) expression breast cancers who are unlikely to respond to treatment unless they have HER2 amplification, and the trial assessed trastuzumab monotherapy rather than chemotherapy combinations where trastuzumab provides the most benefit, with response rates ranging from 42% to 72%. Progress in cancer medicine is achieved by building on Food and Drug Administration–approved drugs through improved patient selection and combination strategies. A major constraint of the study by Marquart et al is that such evolving advances are not considered (eg, a 10% response rate of gefitinib in non–small cell lung cancer was based on an unselected patient population). These historical statistics do not reflect today's clinical practice and are potentially misleading.

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Palliative Care

This Patient Page defines palliative care and explains who may most benefit, when it is most appropriate, and which clinicians might help administer it.

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CancerMoving Precision Oncology Forward Amid Myths and Misconceptions

To the Editor The article by Marquart et al is a clarion call for the strategic application of genome therapies. The study includes patients with metastatic cancer who were eligible for genomic therapy from 2006 through 2018 and concludes that the number of patients eligible for these therapies has increased over time. This increase in eligibility coincides with increasing costs; the price of the chimeric antigen receptor T-cell–based genome therapy Kymriah (Novartis) is $475 000, which restricts public accessibility. Many of these genome therapies lack information about adverse effects or long-term efficacy and have been approved on the basis of single-arm uncontrolled studies with response rates 10% to 20% higher than those reported in subsequent studies or in real-world experience. Marquart et al report that clinical benefits associated with genome therapies were seen in a minority of patients, and the estimated percentage of patients who would have benefited in 2018 did not exceed 4.41%.

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Performance of a Multigene Classifier in Thyroid Nodules With Indeterminate Cytology

This prospective study examines the diagnostic accuracy of a multigene genomic classifier test for diagnosis of benign disease or cancer in thyroid nodules with indeterminate cytology.

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Is Precision Medicine an Oxymoron?

This Viewpoint discusses the initials results of the NCI-MATCH trial, a phase 2 study that seeks to determine whether targeted therapies for specific gene mutations will lead to objective responses agnostic to the primary cancer type.

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Local Control of Brain Metastases With Stereotactic Radiosurgery vs Surgical Resection

This exploratory secondary analysis of a randomized clinical trial evaluated local control of brain metastases among patients treated with stereotactic radiosurgery vs surgical resection in the European Organization for the Research and Treatment of Cancer 22952-26001 phase 3 trial.

https://ift.tt/2Ff07ph

Zinc, copper, cadmium, and lead levels in cattle tissues in relation to different metal levels in ground water and soil

Abstract

The objective of the present study was to investigate the interaction between environmental (water and soil) levels of zinc, copper, cadmium, and lead levels, as well as their content in Hereford beef cattle tissues in five districts (D1—western area, D2 and D3—central area, D4 and D5—eastern area) of the Orenburg region. Soil metal levels were assessed using atomic emission spectrometry, whereas water and tissue (liver, kidney, muscle, heart) metal content was studied using inductively coupled plasma-mass spectrometry. The obtained data demonstrate that the highest levels Zn in soil and water (p < 0.001), as well as cattle muscle, liver, and kidney (p < 0.05) were observed in D4 and D5 (eastern area), exceeding the maximum permissible concentration levels (MPCL) for drinking water and muscle for all regions. Similar associations were found for Cu levels. The highest soil and water Cd and Pb content were observed in D2 (central area) and D5 (eastern area), respectively. At the same time, cattle tissue Cd and Pb content did not correspond to the respective environmental levels. Correlation analysis demonstrated that water and soil Zn and Cu content directly correlated with muscle, liver, and kidney, but not heart metal content. At the same time, water Cd levels were negatively interrelated with muscle cadmium content but correlated directly with hepatic metal content. Both water and soil Pb levels positively correlated with renal metal levels in cattle. In turn, soil lead content was inversely associated with muscle metal levels. Regression analysis also demonstrated a significant association between environmental and tissue levels of Zn and Cu. The models adjusted for all studied elements demonstrated a significant effect of metal interaction on tissue metal levels. Hypothetically, excessive environmental Zn, and possibly Cu, levels may affect the uptake of heavy metals including Cd and Pb from the environment.



https://ift.tt/2ATnjFk

Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public

Abstract

The need to maximize agricultural productivity has made pesticides an indispensable part of current times. Farmers are unaware of the lurking consequences of the pesticide exposure, which endanger their health. It also puts the unsuspecting consumers in peril. The pesticides (from organophosphates, organochlorine, and carbamate class) disrupt the immune and hormonal signaling, causing recurrent inflammation, which leads to a wide array pathologies, including teratogenicity. Numerous farmers have fallen victim to neural disorders–driven suicides and lungs, prostate/breast cancer–caused untimely deaths. Green revolution which significantly escalated agricultural productivity is backfiring now. It is high time that environmental and agricultural authorities act to restrain the excessive usage of the detrimental chemicals and educate farmers regarding the crisis. This review discusses the biological mechanisms of pesticide-driven pathogenesis (such as the activation or inhibition of caspase, serine protease, acetylcholinesterase) and presents the pesticide-exposure-caused health deterioration in USA, India, and Africa. This holistic and critical review should be an eye-opener for general public, and a guide for researchers.



https://ift.tt/2JNMbBp

A case of primary cutaneous peripheral T‐cell lymphoma, not otherwise specified with cytotoxic phenotype showing multiple ulcers on the entire body

Primary cutaneous peripheral T cell lymphoma, not otherwise specified (pcPTCL‐NOS) is a rare, aggressive, fatal type of cutaneous T‐cell lymphoma. The clinical presentation of pcPTCL‐NOS is characterized by generalized plaques, nodules or tumours but ulcers are uncommon. We report an atypical case of pcPTCL‐NOS with cytotoxic protein expression, presenting as multiple ulcers on the entire body. A 48‐year‐old man first presented with pruritic papules on the trunk. The papules gradually increased in number and became ulcerated. We finally diagnosed with pcPTCL‐NOS because of diffuse dermal infiltration of medium‐ to large‐sized pleomorphic CD4 positive lymphoid cells. Ulceration suggests infiltration of lymphoid cells expressing cytotoxic proteins which can induce apoptosis in the epidermis and dermis. Our cases died of bacterial sepsis that invaded from the uncontrollable ulcers. A suspicion of pcPTCL‐NOS is needed when encountering clinical pictures of refractory multiple ulcers and a biopsy should always be performed, because treatment delay may lead a very poor prognosis.

This article is protected by copyright. All rights reserved.



https://ift.tt/2F9BI4z

Three-Dimensional Printed Braided Sleeves for Manufacturing McKibben Artificial Muscles

3D Printing and Additive Manufacturing, Ahead of Print.


https://ift.tt/2JRVccM

Support Optimization for Flat Features via Path Planning in Additive Manufacturing

3D Printing and Additive Manufacturing, Ahead of Print.


https://ift.tt/2ASPZ1a

Depression Symptoms Predict Worse Clinical Response to Etanercept Treatment in Psoriasis Patients

Background/Aims: This study aimed to investigate the predicting values of depression and anxiety symptoms for clinical response to etanercept treatment in psoriasis patients. Methods: A total of 85 psoriasis patients who received 6 months of etanercept treatment were consecutively enrolled in this prospective cohort study. The Psoriasis Area and Severity Index (PASI) score was evaluated at month 0 (M0), M1, M3, and M6, and the corresponding PASI 75/90 response at each visit was assessed. Also, anxiety and depression symptoms were assessed by the Hospital Anxiety and Depression Scale (HADS) at M0, M1, M3, and M6. Results: Depression symptoms were observed to correlate with female gender (p = 0.004), longer disease duration (p = 0.018), and higher PASI score (p #x3c; 0.001), and anxiety symptoms were seen to be associated with female gender (p = 0.017), larger psoriasis-affected body surface area (p = 0.049), and higher PASI score (p = 0.017) in psoriasis patients. After etanercept treatment, HADS-Depression (HADS-D) and HADS-Anxiety (HADS-A) scores were both decreased at M1, M3, and M6 (all p #x3c; 0.001) compared with M0. Most importantly, baseline depressed patients presented with a lower PASI 75 response rate at M3 (p = 0.014) and M6 (p = 0.005), and a reduced PASI 90 response rate at M6 (p = 0.045) compared with baseline non-depressed patients. Furthermore, multivariate logistic regression analyses revealed that depression symptoms at baseline were an independent predictive factor for the lower possibility of both PASI 75 response (p = 0.048) and PASI 90 response (p = 0.048) achievements at M6 in psoriasis patients. However, no correlation of baseline anxiety symptoms with PASI 75/90 responses was observed. Conclusion: Depression symptoms at baseline independently predict a worse clinical response to etanercept treatment in psoriasis patients.
Dermatology

https://ift.tt/2zyX3OK

Scholar : International Journal of Occupational and Environmental Health, Volume 24, Issue 3-4, July - October 2018 is now available online on Taylor & Francis Online

Taylor & Francis Online - The new journals and reference work platform for Taylor & Francis
The online platform for Taylor & Francis Online content
Reviews

Occupational health and safety in cannabis production: an Australian perspective
Maggie Davidson, Sue Reed, Jacques Oosthuizen, Greg O'Donnell, Pragna Gaur, Martyn Cross & Gary Dennis
Pages: 75-85 | DOI: 10.1080/10773525.2018.1517234


Original Articles

Resurgent lead poisoning and renewed public attention towards environmental social justice issues: A review of current efforts and call to revitalize primary and secondary lead poisoning prevention for pregnant women, lactating mothers, and children within the U.S.
Lorenz S. Neuwirth
Pages: 86-100 | DOI: 10.1080/10773525.2018.1507291


Articles

Impact of occupational cadmium exposure on bone in sewage workers
Mona M Taha, Heba Mahdy-Abdallah, Eman M Shahy, Khadiga S Ibrahim & Safaa Elserougy
Pages: 101-108 | DOI: 10.1080/10773525.2018.1518745


Chemical use in the semiconductor manufacturing industry
Sunju Kim, Chungsik Yoon, Seunghon Ham, Jihoon Park, Ohun Kwon, Donguk Park, Sangjun Choi, Seungwon Kim, Kwonchul Ha & Won Kim
Pages: 109-118 | DOI: 10.1080/10773525.2018.1519957


Heat stress in rice vermicelli manufacturing factories
Melvin Seng, Meishan Ye, Kenneth Choy & Sweet Far Ho
Pages: 119-125 | DOI: 10.1080/10773525.2018.1522102


Bio-monitoring of DNA damage in matchstick industry workers from Peshawar Khyber Pakhtunkhwa, Pakistan
Muhammad Khisroon, Ajmal Khan, Ubaid Ullah, Farrah Zaidi & Ahmadullah
Pages: 126-133 | DOI: 10.1080/10773525.2018.1523860


A meta-analysis of airborne asbestos fiber concentrations from work with or around asbestos-containing floor tile
Angela L. Perez, Mindy L. Nelson, Thales J. Cheng, Chris E. Comerford & Paul K. Scott
Pages: 134-148 | DOI: 10.1080/10773525.2018.1533671


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Transdisciplinary Oral/Oropharyngeal Cancer Research & Care in Head and Neck Cancer (TORCH)

Condition:   Head and Neck Cancer
Intervention:   Other: Ancillary/Correlative
Sponsor:   Medical University of South Carolina
Not yet recruiting

https://ift.tt/2QuMYtA

An Phase 1 Study of ZSP1241 in Participants With Advanced Solid Tumors

Conditions:   Hepatocellular Carcinoma;   Cholangiocarcinoma;   Gastric Cancer;   Esophageal Cancer;   Colorectal Cancer
Intervention:   Drug: ZSP1241
Sponsor:   Guangdong Zhongsheng Pharmaceutical Co., Ltd.
Not yet recruiting

https://ift.tt/2PjtEmu

NEO-SPACE Trial: Pembrolizumab and Chemoradiation in Nasopharyngeal Cancer

Condition:   NPC
Intervention:   Drug: Pembrolizumab Injection
Sponsor:   CCTU
Not yet recruiting

https://ift.tt/2QuL4sM

An Study to Evaluate the Safety and Efficacy of Copanlisib in Combination With Nivolumab in Patients With Advanced Solid Tumors

Condition:   Non-small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC), Colorectal Cancer (CRC), Hepatocellular Carcinoma (HCC)
Interventions:   Drug: Copanlisib;   Drug: Nivolumab
Sponsor:   Bayer
Not yet recruiting

https://ift.tt/2Pgz29P

Postoperative Radiotherapy in Thoracic Esophageal Squamous Cell Carcinoma With Neoadjuvant Chemoradiotherapy

Condition:   Radiation Oncology
Interventions:   Radiation: Neoadjuvant Radiotherapy Program:;   Drug: Neoadjuvant chemotherapy Program;   Procedure: Esophagectomy program:;   Radiation: Postoperative radiotherapy program
Sponsor:   Fujian Medical University Union Hospital
Not yet recruiting

https://ift.tt/2QyKx9q

A Study to Evaluate the Safety and Effectiveness of ILIxadencel Administered Into Tumors in Combination With Checkpoint Inhibitor (CPI) in Patients With ADvanced Cancer

Conditions:   Carcinoma, Squamous Cell of Head and Neck;   Carcinoma, Non-Small-Cell Lung;   Gastric Adenocarcinoma;   Gastroesophageal Junction Adenocarcinoma;   Non-small Cell Lung Cancer;   Human Papilloma Virus
Interventions:   Biological: ilixadencel;   Drug: Pembrolizumab
Sponsors:   Immunicum AB;   PPD
Not yet recruiting

https://ift.tt/2Pe8cz4

A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer

Conditions:   Breast Cancer;   Head and Neck Squamous Cell Carcinoma;   Colorectal Cancer;   Bladder Cancer;   Prostate Cancer;   Ovarian Cancer
Intervention:   Drug: ONM-100
Sponsor:   OncoNano Medicine, Inc.
Not yet recruiting

https://ift.tt/2QsoWiF

Oral administration of irinotecan in patients with solid tumors: an open-label, phase I, dose escalating study evaluating safety, tolerability and pharmacokinetics

Abstract

Background

Oral drug formulations have several advantages compared to intravenous formulation. Apart from patient convenience and favorable pharmacoeconomics, they offer the possibility of frequent drug administration at home. In this study, we present a new oral irinotecan formulation designed as an enteric coated immediate release tablet which in pre-clinical studies has shown good exposure with low variability.

Methods

A phase I, dose escalating study to assess safety, tolerability, pharmacokinetics and efficacy of an oral irinotecan formulation and to establish the maximum tolerated dose (MTD). Each treatment cycle was once-daily irinotecan for 14 days followed by 1 week rest.

Results

25 patients were included across four cohorts; 3 patients were included in cohort 1 (20 mg/m2), 7 patients were included in cohort 2 (30 mg/m2), 3 patients were included in cohort 3 (25 mg/m2) and 12 patients were included in cohort 4 (21 mg/m2). Median age was 67 years, 52% were performance status (PS) 0 while 48% were PS 1. Median number of prior therapies was 3 (range 1–6). MTD was established at 21 mg/m2. No responses were observed. Nine patients (36%) had stable disease (SD), lasting median 19 weeks (range 7–45 weeks). Among these five patients had previously received irinotecan. No grade 3/4 hematologic toxicities were reported. Totally six patients experienced grade 1/2 anemia, three patients had grade 1/2 leucopenia and 1 patient had grade 1 thrombocytopenia. Most common non-hematological grade 1 and 2 adverse events were nausea, fatigue, diarrhea, vomiting and cholinergic syndrome. Grade 3 toxicities included diarrhea, fatigue, nausea and vomiting, no grade 4 events were reported. PK data showed consistent daily exposures during treatment at days 1 and 14 and no drug accumulation. SN-38 interpatient variability was in the same range as after infusion.

Conclusions

Oral irinotecan was generally well tolerated; side effects were manageable and similar in type to those observed with intravenous irinotecan. Hematological toxicities were few and only grade 1/2. In this heavily pre-treated patient population, oral irinotecan demonstrated activity even among patients previously treated with irinotecan.



https://ift.tt/2yU7w7S

Steroidal dimer by001 inhibits proliferation and migration of esophageal cancer cells via multiple mechanisms

Abstract

Objective

To investigate the potential inhibitory effects of structurally novel steroidal dimer by001 in esophageal cancer in vitro.

Methods

The cytotoxicity of by001 on esophageal, gastric, neuroblastoma and prostate cancer cells was examined MTT assay and colony formation assay. By001 induced apoptosis and production of intracellular reactive oxygen species on esophageal cancer cells Ec109, TE-1 and human normal gastric epithelial cells GES-1 was detected by flow cytometry. The effect of by001 on mitochondrial membrane potential was detected by fluorescence microscope through JC-1 staining. The level of intracellular reactive oxygen species was measured by fluorescence microscope and flow cytometry via DCFH-DA staining. The effect of by001 on members of Bcl-2 family, Fas, LC3, PARP and caspases was determined by Western blot. The effect of by001 on migration was measured by

transwell assay.

Results

By001 effectively inhibited proliferation of esophageal, gastric, neuroblastoma and prostate cancer cells in a time- and concentration-dependent manner in vitro. By001 reduced the number and the size of colonies at low micromolar concentrations, elevated cellular ROS levels and caused mitochondrial dysfunction in esophageal cancer cells. Molecular mechanistic studies showed that by001 triggered apoptosis through regulating members of Bcl-2 family and Fas.

Conclusions

These findings suggested that by001 may inhibited proliferation of esophageal cancer cells through mitochondria and death receptor-mediated apoptotic pathways, autophagy induction, as well as suppressed migration of esophageal cancer cells.



https://ift.tt/2OrYgNj

Exposure–response relationship of olaratumab for survival outcomes and safety when combined with doxorubicin in patients with soft tissue sarcoma

Abstract

Purpose

Olaratumab is a recombinant human IgG1 monoclonal antibody against PGDFRα. Olaratumab plus doxorubicin improved survivalversus doxorubicin in an open-label, randomised phase 2 soft tissue sarcoma (STS) trial. We characterised the olaratumab exposure–response relationship for progression-free survival (PFS), overall survival (OS), and safety.

Methods

PFS and OS data from the 133 patients enrolled in the phase 2 study were analysed using time-to-event modelling. The effect of olaratumab on PFS/OS was explored using the trough serum concentration after cycle 1 (Cmin1) and the average concentration throughout treatment (Cavg). The rate of treatment-emergent adverse events (TEAEs) was compared across olaratumab exposure quartiles.

Results

PFS and OS were described by models with an exponential hazard function and inhibitory EMAX functions to describe the effect of olaratumab, regardless of the PK endpoint. The olaratumab EC50s for PFS (ECmin150 = 82.0 µg/mL, ECavg50 = 179 µg/mL) and OS (ECmin150 = 66.1 µg/mL, ECavg50 = 134 µg/mL) corresponded to the median and 25th percentile of Cmin1/Cavg in the study, respectively. Maximum predicted improvement in the hazard ratio for OS and PFS was approximately 75% and 60%, respectively. There was no change in the rate of TEAEs with increasing olaratumab serum levels.

Conclusions

PFS/OS benefits occurred without a rate change in TEAEs across quartiles. Maximum benefit in OS was achieved in the upper three quartiles and a potential of early disease progression in the lower quartile of olaratumab serum exposure. These results prompted a loading dose strategy in the ongoing phase 3 STS trial.



https://ift.tt/2yZdyEd

An evaluation of the effects of makeup on perceived age based on skin color in Korean women

Summary

Background

Makeup has been shown to increase women's attractiveness, perceived femininity, and self‐confidence and reduce their perceived age. Some of these results were caused by facial contrast and visible skin color. However, they did not investigate makeup benefit by focusing skin color change.

Objectives

We investigated the benefit of makeup in reducing perceived age by focusing on only skin color, based on the age‐related changes in several skin color parameters (mean, standard deviation, skewness, and kurtosis), and attempted to discover the indications for youthful‐looking skin color.

Methods

A total of 174 Korean women aged 20‐69 years participated in this study. Their digital facial images were cropped on the cheek area, standard Red green Blue data were transformed to Quasi‐L*a*b*, and the statistical parameters of individual Quasi‐L*a*b* data were calculated. Fourteen volunteers aged 30‐45 years wore liquid‐type makeup. The perceived age was assessed by 11 clinical evaluation researchers with a LCD monitor. The statistical analysis was performed using SPSS version 23.0, with a significance level of P < 0.05.

Results

According to a multiple regression analysis, unevenness in skin color, skin lightness, and skewness in skin yellowness significantly affected the participants' perceived age; the most important factor was the unevenness in skin yellowness in Korean women. The evaluated and calculated with the regression equation perceived age were decreased after makeup was applied.

Conclusions

The makeup can reduce women's perceived age by correcting the skin's color, and it can show youthful skin properties such as a lighter and more homogenous color with less chroma.



https://ift.tt/2DtCDLq

Biofilm Induced Profiles of Immune Response Gene Expression by Oral Epithelial Cells

SUMMARY

Objective

This study examined the oral epithelial immunotranscriptome response patterns modulated by oral bacterial planktonic or biofilm challenge

Methods

We assessed gene expression patterns when epithelial cells were challenged with a multispecies biofilm composed of S. gordonii, F. nucleatum, and P. gingivalis representing a type of periodontopathic biofilm compared to challenge with the same species of planktonic bacteria

Results

Of the 579 human immunology genes, a substantial signal of the epithelial cells was observed to 181 genes. Biofilm challenged stimulated significant elevations compared to planktonic bacteria for IL32, IL8, CD44, B2M, TGFBI, NFKBIA, IL1B, CD59, IL1A, CCL20 representing the top 10 signals comprising 55% of the overall signal for the epithelial cell responses. Levels of PLAU, CD9, IFITM1, PLAUR, CD24, TNFSF10, and IL1RN were all elevated by each of the planktonic bacterial challenge versus the biofilm responses. While the biofilms upregulated 123/579 genes (>2‐fold), fewer genes were increased by the planktonic species [36 (S. gordonii), 30 (F. nucleatum), 44 (P. gingivalis)]

Conclusions

A wide array of immune genes were regulated by oral bacterial challenge of epithelial cells that would be linked to the local activity of innate and adaptive immune response components in the gingival tissues. Incorporating bacterial species into a structured biofilm dramatically altered the number and level of genes expressed. Additionally a specific set of genes were significantly decreased with the multispecies biofilms suggesting that some epithelial cell biologic pathways are down‐regulated when in contact with this type of pathogenic biofilm.

This article is protected by copyright. All rights reserved.



https://ift.tt/2JOktUX

Eosinophilic polymorphic and pruritic eruption associated with radiotherapy: case report and overview of disease characteristics



https://ift.tt/2yXgstc

Long-term control of Paget’s disease of bone with low-dose, once-weekly, oral bisphosphonate preparations, in a “real world” setting

Abstract

Purpose

Bisphosphonates are the mainstay of the treatment of Paget's disease of bone (PDB). Clinical practice guidelines recommend treatment with intravenous zoledronic acid or high-dose oral nitrogen bisphosphonates (N-BPs). We present our long-term experience treating PDB patients with lower than recommended oral doses of N-BPs, equivalent to once-weekly doses used for treating osteoporosis.

Methods

PDB patients were seen, between 1990 and 2015 at the endocrine clinic of an academic medical center. Diagnosis was established according to accepted criteria. Patients were initially treated with alendronate 70 mg/week or risedronate 35 mg/week. Whenever the initial dose failed to produce remission, the dosage was increased to twice a week the respective dose.

Results

Patients were followed for a mean of 11.9 years (range: 1.7–24.8). Out of 96 treatment courses with N-BPs, 89% were with alendronate and 11% with risedronate. Remission was achieved in 84% of the courses with alendronate 70 mg/week. 90% of those who did not achieve remission subsequently responded to 140 mg/week. Out of the 8 treatment courses with risedronate 35 mg/week, 87% achieved remission, and the 2 patients who did not achieve remission subsequently responded to 70 mg/week. The median duration of remissions following 3-4 months courses of alendronate 70 mg/week or risedronate 35 mg/week was 8.8 months (IQR: 5.5, 14.8).

Conclusion

In a large proportion of "real world" PDB patients, remission can be achieved with once-weekly, "osteoporosis doses" of alendronate or risedronate.



https://ift.tt/2JOy1Qk

Effects of exenatide and liraglutide on postchallenge glucose disposal in individuals with normal glucose tolerance

Abstract

Purpose

Glucagon-like peptide–1 receptor agonists (GLP-1RAs) are categorized as short- or long-acting types, but information regarding differences in the effects of these two types on postprandial glucose disposal has been limited. We have now investigated the effects of exenatide and liraglutide (short- and long-acting GLP-1RAs, respectively) on glucose disposal during an oral glucose tolerance test (OGTT).

Methods

Fourteen healthy volunteers with normal glucose tolerance underwent three OGTTs, which were performed without pharmacological intervention or after a single administration of exenatide or liraglutide at 30 min and 10 h, respectively, before test initiation. The three OGTTs were performed with intervals of at least 7 days between successive tests and within a period of 2 months.

Results

Exenatide, but not liraglutide, markedly decelerated the peak of both plasma glucose and serum insulin levels during the OGTT, with the peaks of both glucose and insulin concentrations occurring at 150 min after test initiation with exenatide compared with 30 min in the control condition or with liraglutide. Exenatide and liraglutide reduced the area under the curve for plasma glucose levels during the OGTT by similar extents, whereas that for serum insulin levels was reduced only by exenatide.

Conclusions

Our results suggest that exenatide decelerates the increase in plasma glucose levels through inhibition of glucose absorption and that it exerts an insulin-sparing action after glucose challenge.



https://ift.tt/2AThec9

Long-term control of Paget’s disease of bone with low-dose, once-weekly, oral bisphosphonate preparations, in a “real world” setting

Abstract

Purpose

Bisphosphonates are the mainstay of the treatment of Paget's disease of bone (PDB). Clinical practice guidelines recommend treatment with intravenous zoledronic acid or high-dose oral nitrogen bisphosphonates (N-BPs). We present our long-term experience treating PDB patients with lower than recommended oral doses of N-BPs, equivalent to once-weekly doses used for treating osteoporosis.

Methods

PDB patients were seen, between 1990 and 2015 at the endocrine clinic of an academic medical center. Diagnosis was established according to accepted criteria. Patients were initially treated with alendronate 70 mg/week or risedronate 35 mg/week. Whenever the initial dose failed to produce remission, the dosage was increased to twice a week the respective dose.

Results

Patients were followed for a mean of 11.9 years (range: 1.7–24.8). Out of 96 treatment courses with N-BPs, 89% were with alendronate and 11% with risedronate. Remission was achieved in 84% of the courses with alendronate 70 mg/week. 90% of those who did not achieve remission subsequently responded to 140 mg/week. Out of the 8 treatment courses with risedronate 35 mg/week, 87% achieved remission, and the 2 patients who did not achieve remission subsequently responded to 70 mg/week. The median duration of remissions following 3-4 months courses of alendronate 70 mg/week or risedronate 35 mg/week was 8.8 months (IQR: 5.5, 14.8).

Conclusion

In a large proportion of "real world" PDB patients, remission can be achieved with once-weekly, "osteoporosis doses" of alendronate or risedronate.



https://ift.tt/2JOy1Qk

Effects of exenatide and liraglutide on postchallenge glucose disposal in individuals with normal glucose tolerance

Abstract

Purpose

Glucagon-like peptide–1 receptor agonists (GLP-1RAs) are categorized as short- or long-acting types, but information regarding differences in the effects of these two types on postprandial glucose disposal has been limited. We have now investigated the effects of exenatide and liraglutide (short- and long-acting GLP-1RAs, respectively) on glucose disposal during an oral glucose tolerance test (OGTT).

Methods

Fourteen healthy volunteers with normal glucose tolerance underwent three OGTTs, which were performed without pharmacological intervention or after a single administration of exenatide or liraglutide at 30 min and 10 h, respectively, before test initiation. The three OGTTs were performed with intervals of at least 7 days between successive tests and within a period of 2 months.

Results

Exenatide, but not liraglutide, markedly decelerated the peak of both plasma glucose and serum insulin levels during the OGTT, with the peaks of both glucose and insulin concentrations occurring at 150 min after test initiation with exenatide compared with 30 min in the control condition or with liraglutide. Exenatide and liraglutide reduced the area under the curve for plasma glucose levels during the OGTT by similar extents, whereas that for serum insulin levels was reduced only by exenatide.

Conclusions

Our results suggest that exenatide decelerates the increase in plasma glucose levels through inhibition of glucose absorption and that it exerts an insulin-sparing action after glucose challenge.



https://ift.tt/2AThec9

A novel 450-nm blue laser system for surgical applications: efficacy of specific laser-tissue interactions in bladder soft tissue

Abstract

Low-power blue laser allows clean cutting with little bleeding and no undesired coagulations in adjacent tissues; however, studies on high-power blue laser soft tissue ablation properties, including vaporization and coagulation, have not been reported yet. The purpose of this study is to evaluate and analyze the ablation efficacy and coagulation properties of bladder epithelium tissues with a 30-W 450-nm wavelength blue laser. Well-designed ex vivo experiments compared blue laser and 532-nm LBO green laser, both with laser power up to 30 W, for porcine bladder tissue vaporization and coagulation at different experimental parameter settings. At working distance of 1 mm and sweeping speed of 1.5 mm/s, the vaporization efficiency of blue laser and green laser was 5.14mm3/s and 1.20mm3/s, while the depth of coagulation layer was 460 ± 70 μm and 470 ± 80 μm, respectively. We found both blue laser and green laser have excellent efficacy of tissue vaporization and similar tissue coagulation properties. Moreover, in a set of in vivo experiments simulated laser transurethral resection (TUR) surgery on dogs, we found both blue laser and green laser exhibited similar and satisfactory vaporization and coagulation outcomes. Taken together, our results demonstrate that a 450-nm wavelength high-power diode blue laser, like 532-nm wavelength green laser, is capable to produce high efficient tissue vaporization, low-laser tissue penetration, good tissue coagulation, and has low thermal damage to adjacent tissues. Therefore, a 30-W blue diode laser could be a new and safe alternative for surgeries of superficial bladder diseases.



https://ift.tt/2PNiypd

Using the locus of slack logic to determine whether the output form of IOR affects an early or late stage of processing

Publication date: Available online 7 November 2018

Source: Cortex

Author(s): Raymond M. Klein, Maryam Kavyani, Michael A. Lawrence

Abstract

Slower reaction times to targets presented at a previously cued or attended location are often attributed to inhibition of return. It has been suggested that IOR affects a process at the output end of processing continuum when it is generated while the oculomotor system is activated. Following the path set by Kavyani et al. (2017) we used the locus of slack logic embedded in the psychological refractory period (PRP) paradigm to test this idea. We generated what we expected would be the output form of IOR by beginning each with participants making a target directed saccade which was followed by two tasks. Task 1, was a 2-choice auditory discrimination task and Task 2 was a 2-choice visual localization task. We varied the interval between the onsets of the two targets associated with these two tasks (using TTOAs of 200, 400, or 800ms). As expected the visual task suffered from a robust PRP effect (substantially delayed RTs at the shorter TTOAs). There was also a robust IOR effect with RTs to localize visual targets being slower when the targets were presented at a previously fixated location. Importantly, and in striking to our previous results wherein we generated the input form of IOR, in the present study there was an additive effect between IOR and TTOA on RT2. As implied by the locus of slack logic, we therefore conclude that the form of IOR generated when the oculomotor system is activated affects a late stage of processing. Converging evidence for this conclusion, from a variety of neuroscientific methods, is presented and the dearth of such evidence about the input form of IOR is noted.



https://ift.tt/2qygmU6

Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ

Papular stomatitis outbreak in cattle: case report and literature review.

S Răpuntean, A Livescu, T Holirică, G Răpuntean - Romanian Journal of Veterinary …, 2018
We describe an outbreak of bovine papular stomatitis in a backyard (family agricultural
production system). The animal population consists of 22 animals of whom 5 (22.7%)
became ill. The disease developed between November and December 2017. The clinical …
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Analysis of the multifunctionality of Marburg virus VP40

A Koehler, S Pfeiffer, L Kolesnikova, S Becker - Journal of General Virology, 2018
… PLoS Biol 2011;9:e1001196 [CrossRef][PubMed]. [Google Scholar]. 3. Ge P, Tsao J, Schein
S, Green TJ, Luo M et al. Cryo-EM model of the bullet-shaped vesicular stomatitis virus …
The matrix (M) protein of vesicular stomatitis virus regulates transcription …
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Análise citológica para diagnóstico de leishmaniose em um gato oligossintomático em área endêmica, Campo Grande, MS, Brasil

CM dos Santos, AL Tonial, VR Duarte, A Favacho… - Brazilian Journal of Animal …, 2018
… Revista de Patologia Tropical, v. 39, n. 1, p. 33-40, 2010. GIRARD, N.;
PINGRET, JL; MARTIJN, PCM Prevalence of Feline Calicivirus in cats
with Chronic Gingivitis Stomatitis and potential risk factors. Faculty of …
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[HTML] A phase II study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcomas

MM Trucco, CF Meyer, KA Thornton, P Shah, AR Chen… - Clinical Sarcoma Research, 2018
… Of the three unevaluable patients, one withdrew after 20 days of therapy because of
stomatitis, one was removed from the study after 7 days because of persistent Grade 3
elevation of ALT, and one withdrew after 7 days due to clinical deterioration …
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[HTML] Sunitinib Treatment Modification in First-Line Metastatic Renal Cell Carcinoma: Analysis of the STAR-TOR Registry

M BOEGEMANN, M HUBBE, D THOMAIDOU… - Anticancer Research, 2018
… Diarrhoea (34%/17%), fatigue (30%/11%), hand-foot syndrome (28%/10%), and
stomatitis (20%/6%) were more frequently reported in SM versus SS; incidence was
reduced following schedule/dose modification (except diarrhoea) …
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[HTML] A dual-functional priming-capping loop of rhabdoviral RNA polymerases directs terminal de novo initiation and capping intermediate formation

M Ogino, N Gupta, TJ Green, T Ogino - Nucleic Acids Research, 2018
… The L proteins of rhabdoviruses, such as vesicular stomatitis virus (VSV)
and rabies virus (RABV), possess an unconventional mRNA capping enzyme
(GDP polyribonucleotidyltransferase, PRNTase) domain with a loop structure …
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Microalgae: An Untapped Resource for Natural Antimicrobials

J Jena, E Subudhi - The Role of Microalgae in Wastewater Treatment, 2019
… HIV-1 reverse transcriptase and protease. [30]. Venustatriol 302, thyrsiferol 303 and
thyrsiferyl 23-acetate. Vesicular stomatitis. [88]. Vesicular stomatitis Indiana virus,
HSV-l. 304/Laurencia venusta. Table 8.4 Antifungal activity of some algae species …
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METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATORY DISEASES

Y Tan, C Abad-rabat, A Couvineau, T Voisin - US Patent App. 15/767,843, 2018
… idiopathic nephritic syndrome, minimal change nephropathy, benign familial and
ischemia-reperfusion injury, retinal autoimmunity, joint inflammation, bronchitis, chronic
obstructive airway disease, silicosis, aphthae, aphthous stomatitis, arteriosclerotic disorders …
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Bullous autoimmune dermatoses

SC Hofmann, HA Juratli, R Eming - JDDG: Journal der Deutschen Dermatologischen …, 2018
… Initially, painful and prominent hemorrhagic stomatitis with extensive mucosal
erosions and cheilitis dominates the clinical picture (Figure 8a). Cutaneous
findings vary between blisters on the trunk and in intertriginous areas and …
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Coxsackie Virus: Hand-Foot-Mouth Disease

NN Ferguson - Inpatient Dermatology, 2018
… Aphthous stomatitis: the oral lesions will be larger, deeper ulcers, and there is not hand
or foot involvement. Work-Up. Diagnosis can be made through history and physical
examination alone. RT-PCR can detect virus from vesicular …
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Scholar : Obstructive sleep apnea - νέα αποτελέσματα

Blood pressure variability and obstructive sleep apnea. A question of phenotype?

G Bilo, MF Pengo, C Lombardi, G Parati - Hypertension Research, 2018
Obstructive sleep apnea (OSA) is a condition extremely prevalent among
hypertensive patients and evidence is also available indicating its relationship with
incident hypertension. Nonetheless, whether OSA actually causes hypertension is a …
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Obstructive Sleep Apnea after Sleeve Gastrectomy versus Roux-en-Y Gastric Bypass Surgery

M Mozzo, A Sanni, G Arslan, V Jadhav, L Gutierrez - Surgery for Obesity and Related …, 2018
Background: Obstructive sleep apnea (OSA) is a very common co-morbidity in
patients who are morbidly obese. OSA is a progressive life-threatening disorder
characterized by repeated interruptions in upper airway breathing that causes strain …
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Clinical characteristics of obstructive sleep apnea versus infectious adenotonsillar hyperplasia in children

J Johnston, H McLaren, M Mahadevan, RG Douglas - International Journal of …, 2018
Introduction Children who undergo adenotonsillectomy have a range of symptoms.
Some present with infective symptoms, others with obstructive symptoms, and many
with a combination of both. The most common surgical indication has changed over …
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[HTML] Point: Should all patients with atrial fibrillation who are about to undergo pulmonary vein ablation be evaluated for OSA? Yes

R Mehra, O Wazni - Chest, 2018
… Intrinsic to the physiology of obstructive respiratory events (ie, apneas and
hypopneas) are … nervous system responses are elicited subsequent to the
upper airway obstruction, likely exerted by … 7 x7Leung, RS Sleep-disordered …
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… are very prevalent in a lung cancer screening population and may condition lung cancer screening findings: Results of the prospective Sleep Apnea In Lung Cancer …

MT Pérez-Warnisher, E Cabezas, MF Troncoso… - Sleep Medicine, 2018
… Westchester, IL: American Academy of Sleep Medicine; 2005. 22 DM Skillrud,
KP Offord, RD MillerHigher risk of lung cancer in chronic obstructive
pulmonary disease … 503-507. 23 MS Tockman, NR Anthonisen, EC Wright …
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[PDF] Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep

P Zirak, C Gregori-Pla, I Blanco, A Fortuna, G Cotta… - Neurophotonics, 2018
Obstructive apnea causes periodic changes in cerebral and systemic
hemodynamics, which may contribute to the increased risk of cerebrovascular
disease of patients with obstructive sleep apnea (OSA) syndrome. The improved …
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The utility of current criteria for split-night polysomnography for predicting CPAP eligibility

N Wahba, S Sayeeduddin, M Diaz-Abad, SM Scharf - Sleep and Breathing, 2018
… J Clin Sleep Med 10(9):985–990 15. Liistro G, Rombaux P, Belge C, Dury M, Aubert G,
Rodenstein DO (2003) High Mallampati score and nasal obstruction are associated risk
factors for obstructive sleep apnoea. Eur Respir J 21:248–225 16 …
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The Relationship of Temporomandibular Joint, Orofacial Pain, and Sleep Apnea

M Patel, GG Demerjian, AB Sims - Temporomandibular Joint and Airway Disorders, 2018
… Upper airway diseases, nasal obstruction, and hypertrophy of tonsils are
thought to contribute to OSAS … Pathophysiology of pediatric obstructive sleep
apnea. Proc Am Thorac Soc … Clinical, anatomical, and physiologic …
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[HTML] Rebuttal From Drs Mehra and Wazni

R Mehra, O Wazni - Chest, 2018
… 2 x2Gami, AS, Pressman, G., Caples, SM et al. Association of atrial fibrillation and
obstructive sleep apnea. Circulation … 2 x2Gami, AS, Pressman, G., Caples, SM et al.
Association of atrial fibrillation and obstructive sleep apnea. Circulation …
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The incidence of undiagnosed obstructive sleep apnoea (OSA) within an Australian bariatric population

SJ Warner-Smith, MS Pimlico - Surgery for Obesity and Related Diseases, 2018
… Background: It is established that a strong correlation exists between morbid obesity and
obstructive sleep apnea (OSA). OSA has been shown to be associated with increased
incidence of stroke, hypertension and coronary artery disease …
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