Decline patterns and risk assessment of 10 multi-class pesticides in young sprout amaranth ( Amaranthus mangostanus ) under greenhouse growing conditions

Abstract

The present study was designed to investigate the residual decline pattern and the risk assessment of 10 different class pesticides, namely azoxystrobin, boscalid, diazinon, diethofencarb, difenoconazole, etofenprox, flubendiamide, paclobutrazol, and pyraclostrobin in young vegetative amaranth (Amaranthus mangostanus) sprayed once or twice under greenhouse growing conditions. Field-incurred samples, collected at 3, 7, or 10 days after application of both treatments, were extracted and purified with the quick, easy, cheap, effective, rugged, and safe "QuEChERS" citrate-buffered method and analyzed with liquid chromatography-electrospray ionization tandem mass spectrometry (LC-MS/MS) in positive ion mode. The linearity was satisfactory with determination coefficients (R ²) falling between 0.9817 and 0.9999 and limits of detection (LOD) and quantification (LOQ) values of 0.0007 and 0.002 mg/kg, respectively. The mean recovery rate at four spiking levels (equivalent to 5, 10, 50, and 100 × LOQ) ranged from 78.1 to 131.6% with a relative standard deviation (RSD) of < 11%. Substantial differences in the initial deposit between the tested analytes were observed and clearly indicated that the structure, as well as the initial concentration of applied products, greatly affected the residue deposit. From the obtained residual data, the provisional marginal maximum residue limits (MRLs) and the pre-harvest intervals (PHI) were proposed. Risk assessment was evaluated by comparing the theoretical maximum daily intake (TMDI) with the acceptable daily intake (ADI). Herein, the TMDI was lower than the ADI (TMDI/ADI ratio ≤ 80% set by the Korean Ministry of Food and Drug Safety) except for difenoconazole (80.92%, marginally higher), indicating that the vegetative amaranth is not hazardous and can be consumed safely by Korean consumers.

http://ift.tt/2x6GsQE

Evidence for contrasting accumulation pattern of cadmium in relation to other elements in Senilia senilis and Tagelus adansoni from the Bijagós archipelago, Guinea-Bissau

Abstract

Shellfish harvesting in intertidal areas is a widespread and economically important activity in many countries across West Africa. However, in some areas, there is virtually no information concerning the levels of contaminants (and other elements related to nutritional aspects) in the harvested species. We collected sediments and several individuals of the West African bloody cockle Senilia senilis and of the razor clam Tagelus adansoni during the dry season of 2015 nearby three islands in the Bijagós archipelago, Guinea-Bissau. Aluminium, Ca, Fe, Mg, As, Cd, Co, Cr, Cu, Mn, Ni, Pb and Zn were determined in sediments and whole soft tissues of the two bivalves. Sediments showed uniformly low trace element concentrations, pointing to an ecosystem with low levels of trace element contamination. T. adansoni presented higher concentrations of most elements than S. senilis, with the exception of Cd that showed up to 40 times higher values in S. senilis than in T. adansoni from the same sites. Furthermore, Cd concentrations (25±8.7 mg kg⁻¹, dw) in S. senilis are clearly above the maximum level established for human consumption. Future studies should clarify whether biological factors are the major responsible for this unusual situation.

http://ift.tt/2f1NFJG

Characteristic of microplastics in the atmospheric fallout from Dongguan city, China: preliminary research and first evidence

Abstract

Microplastic pollution has exhibited a global distribution, including seas, lakes, rivers, and terrestrial environment in recent years. However, little attention was paid on the atmospheric environment, though the fact that plastic debris can escape as wind-blown debris was previously reported. Thus, characteristics of microplastics in the atmospheric fallout from Dongguan city were preliminarily studied. Microplastics of three different polymers, i.e., PE, PP, and PS, were identified. Diverse shapes of microplastics including fiber, foam, fragment, and film were found, and fiber was the dominant shape of the microplastics. SEM images illustrated that adhering particles, grooves, pits, fractures, and flakes were the common patterns of degradation. The concentrations of non-fibrous microplastics and fibers ranged from 175 to 313 particles/m²/day in the atmospheric fallout. Thus, dust emission and deposition between atmosphere, land surface, and aquatic environment were associated with the transportation of microplastics.

http://ift.tt/2w0x8N2

Coupling population dynamics with earth system models: the POPEM model

Abstract

Precise modeling of CO₂ emissions is important for environmental research. This paper presents a new model of human population dynamics that can be embedded into ESMs (Earth System Models) to improve climate modeling. Through a system dynamics approach, we develop a cohort-component model that successfully simulates historical population dynamics with fine spatial resolution (about 1°×1°). The population projections are used to improve the estimates of CO₂ emissions, thus transcending the bulk approach of existing models and allowing more realistic non-linear effects to feature in the simulations. The module, dubbed POPEM (from Population Parameterization for Earth Models), is compared with current emission inventories and validated against UN aggregated data. Finally, it is shown that the module can be used to advance toward fully coupling the social and natural components of the Earth system, an emerging research path for environmental science and pollution research.

http://ift.tt/2f0iI8s

Morphology and size of blood cells of Rhinella arenarum (Hensel, 1867) as environmental health assessment in disturbed aquatic ecosystem from central Argentina

Abstract

Four populations of Rhinella arenarum from aquatic environments with different degrees of disturbance in central Argentina were compared to assess the ability of cytomorphology and cytomorphometry of blood cells as a hematological biomarker. A total of 93 specimens of R. arenarum (adults sexually mature) were captured during the spring. From the analysis of cell, no variations were found in terms of morphology, whereas in nuclear and cell areas and Price-Jones curves, we observed a smaller size in erythrocytes of individuals inhabiting the site most altered, "Villa Dalcar," as well as for leukocytes, lymphocytes, neutrophils, and eosinophils for the same site. This could be caused by presence of different pollutants in the lake. Furthermore, this was confirmed by the high levels of environmental variables (conductivity, total dissolved solids, and salinity) show that Villa Dalcar is the site most affected by human activities.

http://ift.tt/2w0iUM2

Fecal sludge management in developing urban centers: a review on the collection, treatment, and composting

Abstract

The problems posed by fecal sludge (FS) are multidimensional because most cities rapidly urbanize, which results in the increase in population, urban settlement, and waste generation. Issues concerning health and waste treatment have continued to create alarming situations. These issues had indeed interfered with the proper steps in managing FS, which contaminates the environment. FS can be used in agriculture as fertilizer because it is an excellent source of nutrients. The recent decline in crop production due to loss of soil organic component, erosion, and nutrient runoff has generated interest in the recycling of FS into soil nutrients through stabilization and composting. However, human feces are considerably liable to spread microorganisms to other persons. Thus, sanitation, stabilization, and composting should be the main objectives of FS treatment to minimize the risk to public and environmental health. This review presents an improved FS management (FSM) and technology option for soil amendment that is grouped into three headings, namely, (1) collection, (2) treatment, and (3) composting. On the basis of the literature review, the main problems associated with the collection and treatment of FS, such as inadequate tools and improper treatment processes, are summarized, and the trends and challenges that concern the applicability of each of the technologies in developing urban centers are critically reviewed. Stabilization during pretreatment before composting is suggested as the best method to reduce pathogens in FS. Results are precisely intended to be used as a support for decisions on policies and strategies for FSM and investments for improved treatment facilities.

http://ift.tt/2f0iE8I

Effects of phoxim-induced hepatotoxicity on SD rats and the protection of vitamin E

Abstract

Currently, public pay more attention to the adverse effect of organophosphate pesticides on human and animal health and on the environment in developing nations. Vitamin E may protect the hepatocyte and increase the function of liver. The study was to investigate the effects of phoxim-induced hepatotoxicity on Sprague Dawley (SD) rats and the protection of vitamin E. SD rats received by gavage 180 mg kg⁻¹ (per body weight) of phoxim, 200 mg kg⁻¹ (per body weight) of vitamin E, and phoxim + vitamin E. The results showed that exposure to phoxim elevated liver coefficient; glutamyl transpeptidase (GGT), aspartate aminotransferase, alkaline phosphatase, total bilirubin, total bile acid, and alanine aminotransferase in the serum; ROS in the liver; and the expression of p53, Bax, CYP2E1, ROS, caspase-9, caspase-8, and caspase-3, while phoxim caused a reduction of total protein, albumin, and cholinesterase in the serum; acetylcholinesterase, total antioxidant capacity, glutathione peroxidase, and glutathione in the liver; and the expression of Bcl-2. Vitamin E modified the phoxim-induced hepatotoxicity by reducing the GGT in the serum, malondialdehyde in the liver, and the expression of CYP2E1 significantly. There were no significant changes of globulin in the serum, the activity of catalase in the liver, as well as expression levels of Fas and Bad in the liver. Overall, subacute exposure to phoxim induced hepatic injury, oxidative stress damage, and cell apoptosis. Vitamin E modified phoxim-induced hepatotoxicity slightly. And, vitamin E minimized oxidative stress damage and ultrastructural changes in rat hepatocytes notably.

http://ift.tt/2f0iD4E

Cadmium losses in overland flow from an agricultural soil

Abstract

Cadmium (Cd) transport in overland flow from agricultural soils is potentially important when trying to predict future soil Cd concentrations, but at present there is little information on the magnitude of loss from this pathway. This study measured Cd concentrations and fluxes in overland flow from a catchment where cattle winter-grazed a forage crop (kale) (Brassica oleracea) in year one and measurements continued in year two when the catchment was returned to pasture and grazed by sheep. Flow-weighted mean concentrations (FWMC) of total, particulate and dissolved Cd in overland flow events from the forage crop were 0.49, 0.41 and 0.08 μg L⁻¹, respectively. In contrast, no dissolved Cd was detected in overland flow from pasture, with a FWMC of total Cd of 0.09 μg L⁻¹. In line with the Cd concentrations, total Cd fluxes were greater from the forage crop (0.06 g Cd ha⁻¹ year⁻¹) than from pasture (0.04 g Cd ha⁻¹ year⁻¹). Cadmium losses in overland flow were relatively minor compared with those reported for other pathways such as plant uptake or subsurface flow. Further, compared to the amount of Cd that is currently added to soil in a maintenance application of phosphate fertiliser (30 kg P ha⁻¹ year⁻¹) which is on average 5.5 g Cd ha⁻¹, Cd losses in overland flow represented < 1% of inputs. Measurement of Cd losses in overland flow should be undertaken at other sites to confirm the low Cd losses found in this study, along with the distribution between dissolved and particulate fractions.

http://ift.tt/2w0K7Os

Chemotherapy for advanced HER2-negative breast cancer: can one algorithm fit all?

Publication date: Available online 15 September 2017
Source:Cancer Treatment Reviews
Author(s): F. Miglietta, M.V. Dieci, G. Griguolo, V. Guarneri, P.F. Conte
HER2negative (HER2-) metastatic breast cancer (MBC) represents a challenging scenario for clinicians due to its great biological and clinical heterogeneity. Although management of HER2-MBC currently relies on several options, CT still remains a worthwhile strategy to be exploited. However, to date, there is not an univoque algorithm capable of guiding the choice of the proper CT agent/regimen, sequence and duration. Evidence from randomized clinical trials (RCT) and meta-analyses can actually help guiding the decision making process, however the definition of a standard of care for all HER2-MBC patients may be impractical, also in the light of the identification of new promising molecular and immunotherapeutic agents. The purpose of this work is to review available evidence on the role of CT for HER2-MBC with particular emphasis on the need to outline personalized therapeutic strategies for each patient.



http://ift.tt/2xpiLoM

Novel fabrication of nano functionalized amorphous tungsten oxide coatings with colorful superamphiphobic surface study

Publication date: 5 December 2017
Source:Materials & Design, Volume 135
Author(s): Bingbing Xia, Hongtao Liu, Yinan Fan, Tianchi Chen, Chao Chen, Bo Wang
Fabrication of surfaces with capability of repelling both water and oil is badly needed. Meanwhile, the widespread use of nanomaterials has also attracted great interest in this field. In this paper, we provided novel methods to synthesize nano amorphous tungsten oxide coatings on Al-Mg metals. After modification with FAS-17, the surface could obtain excellent superamphiphobic abilities with lower sliding angles and higher contact angles to water and oil. In addition, outstanding anti-oil pollutant and low adhesion were obtained. Furthermore, the as-prepared superamphiphobic surfaces could survive 200cm abrasion distance under 19.6kPa pressure on 1000grid SiC sandpaper. It should be noted that this coatings could obtain different colors in different temperature. Meanwhile, we found that the droplets with lower surface energy and low viscosity are easier to bounce than the droplets with high surface energy and high viscosity. So the simple procedure and excellent superamphiphobicity about fabricating colorful tungsten oxide coatings have great potential in protecting Al-Mg metal and have potential applied in signals which need to prevent wetting or pollution by water and oils. On one level, this method about synthesizing nano amorphous tungsten oxide also has more promising using in other fields.

Graphical abstract

http://ift.tt/2jxBGZx

Microstructural evolution and properties of TLP diffusion bonding super-Ni/NiCr laminated composite to Ti-6Al-4V alloy with Cu interlayer

Publication date: 5 December 2017
Source:Materials & Design, Volume 135
Author(s): Kun Liu, Yajiang Li, Chunzhi Xia, Juan Wang
Transient liquid phase (TLP) diffusion bonding super-Ni/NiCr laminated composite to Ti-6Al-4V alloy was performed at 950°C with the pressure of 5MPa. Two configurations (super-Ni/Cu/Ti-6Al-4V and Ni80Cr20/Cu/Ti-6Al-4V) were designed to explore interfacial microstructure evolution and mechanical properties. Results showed that the joint of laminated composite and Ti-6Al-4V alloy was mainly divided into two diffusion layers and a reaction layer. The interface was composed of Ni(Cu), Cu(Ni), Ti2Cu, TiCu, Ti3Cu4, Ti2Cu3 and Ti-Cu eutectic microstructure. The width of each layer increased with prolonging the bonding time and the growth rate of interfacial layers was dominated by the diffusion rate of alloying elements i.e. Cu, Ni and Ti. The maximum value of shear strength for both two configurations was about 58MPa.

Graphical abstract

http://ift.tt/2jy5J3a

Th9 cells promote antitumor immunity via IL-9 and IL-21 and demonstrate atypical cytokine expression in breast cancer

Publication date: November 2017
Source:International Immunopharmacology, Volume 52
Author(s): Fa-Ping You, Jian Zhang, Tao Cui, Rui Zhu, Chong-Qing Lv, Hai-Tao Tang, Di-Wen Sun
Breast cancer is a major cause of cancer-related death in women. Antitumor T cell responses play critical therapeutic roles, including direct cytotoxicity mediated by CD8⁺ T cells and immunomodulatory roles mediated by CD4⁺ T cells. The IL-9-expressing Th9 cells are recently found to present antitumor immunity in melanoma and lung adenocarcinoma. In this study, we found that IL-9 expression in the serum and in circulating CD4⁺ T cells were significantly upregulated in breast cancer patients compared to healthy controls. The IL-9-expressing Th9 cells were enriched in the CCR4⁻CCR6⁻CXCR3⁻ subset. Upon TCR stimulation, this subset also presented potent IL-10 and IL-21 expression in addition to IL-9 expression. CCR4⁻CCR6⁻CXCR3⁻ CD4⁺ T cells also assisted in the killing of autologous tumor cells by CD8⁺ T cells, but did not initiate cytotoxicity by themselves. This enhancement in CD8⁺ T cell-mediated cytotoxicity was dependent on IL-9 as well as on IL-21. Interestingly, the tumor-infiltrating Th9 cells presented comparable IL-9, reduced IL-10, and elevated IL-21 expression compared with their counterparts in the peripheral blood. Together, these results demonstrated that IL-9-expressing Th9 cells were upregulated in breast cancer patients and potentially possessed antitumor roles by enhancing CD8⁺ T cell-mediated cytotoxicity.



http://ift.tt/2x9Mi5x

Radioactive seed migration following parotid gland interstitial brachytherapy

Publication date: Available online 15 September 2017
Source:Brachytherapy
Author(s): Yi Fan, Ming-wei Huang, Yi-jiao Zhao, Hong Gao, Jian-Guo Zhang
PurposeTo evaluate the incidence and associated factors of pulmonary seed migration after parotid brachytherapy using a novel migrated seed detection technique.Methods and MaterialsPatients diagnosed with parotid cancer who underwent permanent parotid brachytherapy from January 2006 to December 2011 were reviewed retrospectively. Head and neck CT scans and chest X-rays were evaluated during routine follow-up. Mimics software and Geomagic Studio software were used for seed reconstruction and migrated seed detection from the original implanted region, respectively. Postimplant dosimetry analysis was performed after seeds migration if the seeds were still in their emitting count. Adverse clinical sequelae from seed embolization to the lung were documented.ResultsThe radioactive seed implants were identified on chest X-rays in 6 patients. The incidence rate of seed migration in 321 parotid brachytherapy patients was 1.87% (6/321) and that of individual seed migration was 0.04% (6/15218 seeds). All migrated seeds were originally from the retromandibular region. No adverse dosimetric consequences were found in the target region. Pulmonary symptoms were not reported by any patient in this study.ConclusionsIn our patient set, migration of radioactive seeds with an initial radioactivity of 0.6–0.7 mCi to the chest following parotid brachytherapy was rare. Late migration of a single seed from the central target region did not affect the dosimetry significantly, and patients did not have severe short-term complications. This study proposed a novel technique to localize the anatomical origin of the migrated seeds during brachytherapy. Our evidence suggested that placement of seeds adjacent to blood vessels was associated with an increased likelihood of seed migration to the lungs.



http://ift.tt/2fqvOwF

Dangling regimes after free flap reconstruction of the lower limb; further evidence is required

We read with interest the recent systematic review by McGhee et al.1 on flap survival and morbidity following early post-operative rehabilitation after lower limb free flap reconstruction, where it was concluded that post-operative dangling confers physiological benefit in flap healing.

http://ift.tt/2fcqPTg

Information content of dendritic spines after motor learning

Publication date: 15 January 2018
Source:Behavioural Brain Research, Volume 336
Author(s): Davide Viggiano, Luisa Speranza, Marianna Crispino, Gian Carlo Bellenchi, Umberto di Porzio, Attilio Iemolo, Elvira De Leonibus, Floriana Volpicelli, Carla Perrone-Capano
Dendritic spines, small protrusions emerging from the dendrites of most excitatory synapses in the mammalian brain, are highly dynamic structures and their shape and number is continuously modulated by memory formation and other adaptive changes of the brain.In this study, using a behavioral paradigm of motor learning, we applied the non-linear analysis of dendritic spines to study spine complexity along dendrites of cortical and subcortical neural systems, such as the basal ganglia, that sustain important motor learning processes.We show that, after learning, the spine organization has greater complexity, as indexed by the maximum Lyapunov exponent (LyE). The positive value of the exponent demonstrates that the system is chaotic, while recurrence plots show that the system is not simply composed by random noise, but displays quasi-periodic behavior. The increase in the maximum LyE and in the system entropy after learning was confirmed by the modification of the reconstructed trajectories in phase-space. Our results suggest that the remodeling of spines, as a result of a chaotic and non-random dynamical process along dendrites, may be a general feature associated with the structural plasticity underlying processes such as long-term memory maintenance.Furthermore, this work indicates that the non-linear method is a very useful tool to allow the detection of subtle stimulus-induced changes in dendritic spine dynamics, giving a key contribution to the study of the relationship between structure and function of spines.



http://ift.tt/2ydI3EF

Scholar : Ειδοποίηση Μελετητή - [ CPAP ]

Ειδοποίηση Μελετητή:[ CPAP ]

Sleep disordered breathing controlled by CPAP and sFlt-1 in a pregnant patient with chronic hypertension: Case report and literature review

A Daly, A Robertson, G Bobek, S Middleton, C Sullivan… - Obstetric Medicine, 2017

Background There is recent interest exploring the possible impact of sleep disordered
breathing on the mechanisms of preeclampsia. A biomarker of preeclampsia, soluble fms-
like tyrosine kinase-1, has come to prominence in recent years. The aim of this study was to

Treating OSA: Current and emerging therapies beyond CPAP

G Lorenzi‐Filho, FR Almeida, PJ Strollo - Respirology, 2017

ABSTRACT Continuous positive airway pressure (CPAP) is the standard treatment for
moderate-to-severe obstructive sleep apnoea (OSA). However, adherence to CPAP is
limited and non-CPAP therapies are frequently explored. Oral appliance (OA) therapy is

Characteristics of children enrolled in Medicaid using respiratory equipment and supplies

D Gaur - 2017

... of Diseases (ICD9) codes, billed by clinicians and hospitals. RMES included oxygen,
suctioning, apnea monitor, CPAP/BiPAP, tracheostomy, ventilator, cough assist, and
vest. We regressed RMES use on total annual per member ...

Israel rake retractor modification to improve exposure during oropharyngeal surgery on patients with larger body habitus

AM Vahabzadeh-Hagh, E Ramirez - Sleep and Breathing, 2017

... The gold standard treatment of OSA is non-invasive positive pressure, such as
continuous positive airway pressure (CPAP). However, 30–50% of patients with OSA
do not tolerate CPAP and another 10–20% refuse to even try it. ...

Effects of Patent Foramen Ovale closure on Obstructive Sleep Apnoea Syndrome (PCOSA study)

SP Hoole, J Hernández-Sánchez, WR Davies… - Canadian Journal of …, 2017

... desaturation index (ODI), apnoea-hypopnoea index (AHI), Epworth Sleepiness Score (ESS),
6-minute walk test (6MWT) and Sleep Apnoea Quality of Life Index (SAQLI) were compared in
these patients at baseline (before continuous positive pressure ventilation (CPAP)) and at ...

Testing the Performance of Positive Airway Pressure Generators: From Bench to Bedside

K Zhu, CC des Francs, A Sagniez, P Escourrou - Sleep Medicine Clinics, 2017

... Continuous PAP (CPAP) devices are used in most sleep apnea patients in the long term, but
the settings are usually titrated during several nights at home, using an auto-adjusting PAP (APAP)
because manual titration in the sleep laboratory is costly and suffers long waiting lists ...

CT Characterization and Comparison with Polysomnography for Obstructive Sleep Apnea Evaluation

K Chousangsuntorn, T Bhongmakapat, N Apirakkittikul… - Journal of Oral and …, 2017

... For deciding an appropriate OSA therapeutic approach, patients should be included in the
discussion of treatment options [1]. Continuous positive airway pressure (CPAP) is the standard
treatment for moderate to severe OSA, and is an optional therapeutic method for mild OSA ...

Practical Considerations in the Treatment of Pediatric Obstructive Sleep Apnea

A Isaiah, SO Ulualp - Recent Advances in Pediatric Medicine: Synopsis of …, 2017

... These patients are subsequently referred to the sleep physician for potentially considering
continuous positive air pressure (CPAP) therapy. Although CPAP is highly effective in
the management of residual OSAS, compliance is very low [46]. ...

"Silent" Sleep Apnea in Dentofacial Deformities and Prevalence of Daytime Sleepiness after Orthognathic/Intranasal Surgery

JC Posnick, A Adachie, N Singh, E Choi - Journal of Oral and Maxillofacial Surgery, 2017

... Published studies consistently document that maxillomandibular advancement (MMA) is the most
effective surgical treatment for OSA with results that are comparable to the efficacy of therapeutic
use of continuous positive airway pressure (CPAP) 11; 12; 13; 14; 15; 16; 17; 18 ...

Sleep-disordered breathing and the risk of cognitive decline: a meta-analysis of 19,940 participants

X Zhu, Y Zhao - Sleep and Breathing, 2017

... be as high as 60% [2]. Previous studies indicated that SDB may be an in- dependent risk factor
for many diseases, including hyperten- sion, cardiovascular diseases, and stroke [3–5].
Accordingly, the treatment of SDB via continuous positive airway pressure (CPAP) has shown ...

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Scholar : Ειδοποίηση Μελετητή - [ ΣΤΟΜΑ

Ειδοποίηση Μελετητή:[ ΣΤΟΜΑΤΙΤΙΣ ]

[HTML] Development of an HIV vaccine using a vesicular stomatitis virus vector expressing designer HIV-1 envelope glycoproteins to enhance humoral responses

T Racine, GP Kobinger, EJ Arts - AIDS Research and Therapy, 2017

Abstract Vesicular stomatitis virus (VSV), like many other Rhabdoviruses, have become the
focus of intense research over the past couple of decades based on their suitability as
vaccine vectors, transient gene delivery systems, and as oncolytic viruses for cancer

Evaluation of analgesic effect and absorption of buprenorphine after buccal administration in cats with oral disease

TR Stathopoulou, M Kouki, BH Pypendop, A Johnston… - Journal of Feline Medicine …, 2017

Objectives The objective of this study was to evaluate the analgesic effect and absorption
of buprenorphine after buccal administration in cats with oral diseas...

Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: Rationale for lower dosage in Asia.

X Zhou, DR Mould, T Takubo, E Sheldon-Waniga… - British journal of clinical …, 2017

... 53.6%], respectively). Exposure-adverse event relationships could be described
for neutropenia, stomatitis and diarrhoea, supporting the lower dosage of alisertib
in Asia for global clinical development. CONCLUSIONS: Model ...

Recent advances in vaccine development against Ebola threat as bioweapon

P Gera, A Gupta, P Verma, J Singh, J Gupta - VirusDisease, 2017

... In 2007, Jones and coworkers assessed the vaccine based on vesicular stomatitis virus (VSV)
by using mouse model of Ebola virus hemorrhagic fever. ... Vesicular stomatitis virus- based ebola
vaccine is well-tolerated and protects immunocom- promised nonhuman primates. ...

Microorganism colonization on surfaces of maxillary obturators, maxillary defect and in saliva: A cross-sectional study

T Celakil, E Baca, EN Topcuoglu, BG Röhlig… - Brazilian Dental Science, 2017

... The highest amount of Staphylococcus aureus was found in the saliva and nasal cavity in the
definitive soft lining material group (50%). Short renewal period of lining materials may cause
less Candida albicans colonisation and denture stomatitis in the oral cavity. ...

[HTML] Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine

TH Kim, S Shin, S Kim, JB Bulitta, KY Weon, SH Joo… - Molecules, 2017

Gemcitabine and erlotinib are the chemotherapeutic agents used in the treatment of various
cancers and their combination is being accepted as a first-line treatment of advanced pancreatic
cancer. Hyangsayukgunja-tang (HYT) is a traditional oriental medicine used in various digestive ...

Lentiviral gene delivery to plasmolipin-expressing cells using Mus caroli endogenous retrovirus envelope protein

MM Prokofjeva, GM Proshkina, TD Lebedev… - Biochimie, 2017

... PLLP; Plasmolipin; ROS; Reactive oxygen species; VSV; Vesicular stomatitis virus. ... Lentiviral
vectors pseudotyped with surface glycoprotein of vesicular stomatitis virus (VSV-G), which uses
low-density lipoprotein receptor (LDL-R) for cell entry [13], were used as control. ...

Desmoid tumours in children: when wait-and-see becomes wait-and-treat

A Weiss, D Hawkins - The Lancet Child & Adolescent Health, 2017

... 3 In a subsequent prospective study in children 4 using the more targeted agents tamoxifen and
sulindac, 2-year progression-free survival was 36%. Both regimens caused substantial adverse
effects, such as myelotoxicity, nausea, vomiting, stomatitis, and ovarian cysts. ...

[HTML] A novel HIV vaccine targeting the protease cleavage sites

H Li, RW Omange, FA Plummer, M Luo - AIDS Research and Therapy, 2017

... incorporated in the virion. The PCS vaccine under evaluation uses 12 different
recombinant vesicular stomatitis viruses (rVSV), each expressing a 20-amino acid
peptide overlapping one of the 12 PCS. Vaccination with a combination ...

[HTML] Feasibility, Safety, and Efficacy of an Alternative Schedule of Sunitinib for the Treatment of Patients with Metastatic Renal Cell Carcinoma: A Retrospective Study

S Buti, M Donini, M Bersanelli, A Gattara, F Leonardi… - Drugs in R&D, 2017

... After the switch, 48.7% of patients obtained a toxicity reduction (hypertension -82%, stomatitis
-71%, cutaneous toxicity -69%). ... There was a strong tendency towards a lower incidence of
stomatitis, hand–foot syndrome, and rash with the 2/1 schedule. ...

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