The Association of Handgrip Strength and Mortality: What Does It Tell Us and What Can We Do With It?

Rejuvenation Research, Ahead of Print.


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“Aging, Geroscience, and Freedom”

Rejuvenation Research, Ahead of Print.


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Clinical Thyroidology®High-Impact Articles

FREE ACCESS through November 1, 2018.
Read Now:

Paul Walfish—In Memoriam
Anthony Hollenberg, Jerome M. Hershman 

Radioactive Iodine Therapy Is Associated with Clonal Hematopoiesis, a Precursor for Hematologic Malignancies
Brian W. Kim  

Persistent Disease is 3.5-Fold More Common Than Recurrent Disease After Initial Therapy for Differentiated Thyroid Cancer
Jerome M Hershman  

Male Sex Is Associated with Increased Mortality from Papillary Thyroid Cancers with BRAF V600E Mutation
Lauren E. Orr, Michael W. Yeh, Masha J. Livhits  

Varying Levothyroxine Doses Within or Near the Reference Range Does Not Affect Energy Expenditure or Body Composition
Elizabeth N. Pearce  

Levothyroxine Replacement for Primary Hypothyroidism Can Be Given Between Meals with Similar Effectiveness at Various Times of the Day
Charles H. Emerson

The post Clinical Thyroidology^®High-Impact Articles appeared first on American Thyroid Association.

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How do you treat a droopy eyelid?

Ptosis refers to a droopy eyelid, where the upper eye area lowers downward. Causes include genetics, eye surgery, and excessive rubbing. Treatment can involve surgery, but usually for cosmetic reasons only. Prevention is harder due to genes playing a role. Learn more about this manageable condition here.

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Anti-Aging Passion and Pragmatism: Effective Bedfellows at Last

Rejuvenation Research, Volume 21, Issue 5, Page 387-388, October 2018.


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Prevention of Senescence in Vasculature Through Quiescence

Rejuvenation Research, Volume 21, Issue 5, Page 477-481, October 2018.


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Crowdfunding Model for Conducting Clinical Studies

This Viewpoint describes a process of conducting medical research that uses online crowdfunding as a model for recruiting and reviewing investigators and data.

https://ift.tt/2AhzeMZ

Assessing the Validity of Clinician Advice on Topical Agent Use Before Radiotherapy

This survey study of patients undergoing radiotherapy for cancer compares clinician advice against using topical agents before radiotherapy to avoid an increased radiation dose to the skin with the results of a dosimetric study and a preclinical study in an animal model.

https://ift.tt/2QXzYw9

Use of Trend Statements to Describe Statistically Nonsignificant Results in the Oncology Literature

This study examines recent original research articles in leading oncology journals to evaluate the use of statements about the trend of a P value toward significance to describe statistically nonsignificant results.

https://ift.tt/2Ahz4oR

Diagnosis, Prognosis, and Treatment of Alveolar Soft-Part Sarcoma

This narrative review discusses current understanding of alveolar soft-part sarcomas with a focus on new findings and treatments.

https://ift.tt/2QZqUa1

Debunking Advice to Avoid Topical Agents Before Radiotherapy

The clinical science of radiotherapy (RT) has evolved considerably since the early use of low-energy (150- to 300-kV) orthovoltage x-rays, which deposit much of their energy at the skin surface. Indeed, the skin "erythema dose" was the primary means of standardizing radiation doses given the limited tangible criteria for documenting radiation effects at the time. Contemporary RT uses high-energy photons that deposit their maximum dose several centimeters below the skin surface. Nevertheless, in 90% to 95% of cases, moderate to high doses of this megavoltage radiation can lead to acute radiation dermatitis, which begins as erythema during the first 2 weeks of treatment before progressing to dry desquamation, and, in some cases, on to moist desquamation. Management of these reactions varies; preventive and interventional strategies have included frequent washing with mild soap and using topical dressings and corticosteroidal and noncorticosteroidal topical agents.

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Progestin, Not Progesterone

To the Editor In their article on breast cancer risk in BRCA1 mutation carriers who were given hormone replacement therapy postovariectomy, the authors use the word "progesterone" throughout without explanation or qualification. The corresponding author affirmed that most of these women received various progestins, not progesterone.

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Alisertib Plus Paclitaxel in Patients With Advanced Breast Cancer or Recurrent Ovarian Cancer

This phase 1 and 2 clinical trial examines progression-free survival in patients with ovarian or breast cancer treated with alisertib in combination with paclitaxel vs paclitaxel alone.

https://ift.tt/2Ahyojj

Current approaches to immunotherapy in noncolorectal gastrointestinal malignancies

Noncolorectal gastrointestinal (GI) malignancies are among the most frequently diagnosed cancers. Despite the undeniable progress in systemic treatments in recent decades, further improvements using cytotoxic chemotherapy seem unlikely. In this setting, recent discoveries regarding the mechanism underlying immune evasion have prompted the study of molecules capable of inducing strong antitumor responses. Thus, according to early data, immunotherapy is a very promising tool for the treatment of patients with GI malignancies. Noncolorectal GI cancers are a major public health problem worldwide. Traditional treatment options, such as chemotherapy, surgery, radiation therapy, monoclonal antibodies and antiangiogenic agents, have been the backbone of treatment for various stages of GI cancers, but overall mortality remains a major problem. Thus, there is a substantial unmet need for new drugs and therapies to further improve the outcomes of treatment for noncolorectal GI malignancies. "Next-generation" immunotherapy is emerging as an effective and promising treatment option in several types of cancers. Therefore, encouraged by this recent success, many clinical trials evaluating the efficacy of immune checkpoint inhibitors and other strategies in treating noncolorectal GI malignancies are ongoing. This review will summarize the current clinical progress of modern immunotherapy in the field of noncolorectal GI tumors.

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Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis

We compare here the principal characteristics of over-the-counter moisturizers with physiologic lipid-based barrier repair therapy. Moisturizers are standard ancillary therapy for anti-inflammatory skin disorders, like atopic dermatitis (AD), and can attenuate the emergence of AD, the initial step in the "atopic march." But not all moisturizers are beneficial; some can make skin function worse, and can even induce inflammation, possibly accounting for the frequent occurrence of "sensitive skin" in women. In contrast, physiologic lipid-based barrier repair therapy, if comprised of the 3 key stratum corneum lipids, in sufficient quantities and at an appropriate molar ratio, can correct the barrier abnormality and reduce inflammation in AD, and perhaps in other inflammatory dermatoses.
Skin Pharmacol Physiol 2019;32:1–7

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Rheology of hyaluronic acid and dynamic facial rejuvenation: Topographical specificities

Journal of Cosmetic Dermatology, Volume 17, Issue 5, Page 736-743, October 2018.


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JCD Commentary for September 2018

Journal of Cosmetic Dermatology, Volume 17, Issue 5, Page 649-649, October 2018.


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Issue Information

Journal of Cosmetic Dermatology, Volume 17, Issue 5, Page 643-644, October 2018.


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Issue Information

International Journal of Cosmetic Science, Volume 40, Issue 5, Page i-iv, October 2018.


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Autoimmunity risk- and protection-associated IL7RA genetic variants differentially affect soluble and membrane IL-7Rα expression

Publication date: Available online 17 October 2018

Source: Journal of Autoimmunity

Author(s): Christian Lundtoft, Julia Seyfarth, Sonja Oberstrass, Joachim Rosenbauer, Christina Baechle, Michael Roden, Reinhard W. Holl, Ertan Mayatepek, Sebastian Kummer, Thomas Meissner, Marc Jacobsen

Abstract

Interleukin-7 receptor α-chain (IL7RA) haplotypes are associated with susceptibility to autoimmune diseases including type 1 diabetes (T1D). Previous studies found lower soluble IL-7Rα (sIL-7Rα) serum levels of the protection-associated IL7RA haplotype assumed to reduce IL-7 availability for self-reactive T cells. Also, a risk-associated IL7RA haplotype is accompanied by lower sIL-7Rα serum concentrations but no underlying mechanisms have been described and the causative polymorphism remains unknown.

Here, we characterized functional implications of the nonsynonymous rs1494558 (Thr66Ile), which tags the protection-associated IL7RA haplotype, in HEK293T cells and serum samples of T1D patients with different haplotype carriers. Influence of risk- and protection-associated haplotypes on IL-7Rα was analyzed.

The risk-associated Ile66 variant affected gel mobility and impaired secretion of the sIL-7Rα as well as expression of the membrane-associated (m)IL-7Rα in HEK293T cells. Serum sIL-7Rα analyses confirmed differential gel mobility of the Ile66 variant and found decreased sIL-7Rα serum levels of T1D patients carrying the Ile66-tagged haplotype. Differences in glycosylation were not causative for differential mobility but enhanced the effects on impaired secretion. Comparison of protection- and risk-associated haplotypes in a cell line-based in vitro model identified dominant effects of the protective haplotype tagged by rs6897932 (Ile244) on mIL-7Rα expression, whereas the risk haplotype mainly affected the sIL-7Rα.

This study identified novel functional effects of the Ile66 IL7RA variant and characterized features of autoimmunity risk- and protection-associated haplotypes. The findings add to our understanding of how these haplotypes regulate sIL-7Rα and mIL-7Rα expression in T cells causing differential susceptibility to autoimmune diseases.

Graphical abstract

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Oculomotor control after hemidecortication: One hemisphere encodes normal ipsilateral oblique anti-saccades

Publication date: Available online 17 October 2018

Source: Cortex

Author(s): Olga Savina, Daniel Guitton

Abstract

A critical question in neurology is how the brain reorganizes its structure and function following injury. Here, we consider oculomotor control following a massive brain lesion, a hemispherectomy. We used the oblique anti-saccade task which requires the suppression of a saccade towards a visual cue, flashed anywhere in a patient's seeing hemifield, and the generation, in the dark, of an anti-saccade to a task-dependent location in the opposite blind hemifield; inverting either the horizontal or both horizontal and vertical components. Anti-saccades require a visuo-motor vector inversion that normally involves bilateral interactions between frontal, parietal and subcortical structures across both hemispheres. Here, oblique anti-saccades presented a major challenge to the patient's single hemisphere, requiring one site in visual cortex to communicate with an instruction-dependent site in oculomotor cortex. Patients with discrete frontal lobe damage can be strongly impaired in anti-saccades. By contrast, hemispherectomy patients performed oblique anti-saccades normally, contrasting with their permanent contralesional hemianopia and severe hemiparesis.

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Scholar : Asian Englishes, Volume 20, Issue 3, November 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Asian Englishes, Volume 20, Issue 3, November 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Editorials Editorial James D'Angelo Pages: 191-191 | DOI: 10.1080/13488678.2018.1525792 Articles Intonation patterns of questions in Malaysian English Tsong Shiuan Yap & Stefanie Pillai Pages: 192-205 | DOI: 10.1080/13488678.2017.1405707 Using folktales as a way to operationalise the paradigm of teaching English as an international language Soe Marlar Lwin & Roby Marlina Pages: 206-219 | DOI: 10.1080/13488678.2018.1440279 Original Articles Tense-lax merger: Bangla as a first language speakers' pronunciation of English monophthongs A. R. M. Mostafizar Rahman Pages: 220-241 | DOI: 10.1080/13488678.2017.1327834 Split infinitives across World Englishes: a corpus-based investigation Wilkinson Daniel Wong Gonzales & Shirley N. Dita Pages: 242-267 | DOI: 10.1080/13488678.2017.1349858 Essays On language, culture, and controversies Jeremie Bouchard Pages: 268-278 | DOI: 10.1080/13488678.2018.1449487 Book Review Translanguaging in higher education: beyond monolingual ideologies Abigail M. Ocampo Pages: 279-282 | DOI: 10.1080/13488678.2017.1390186 Do you have original research that relates to present-day Japan and its recent historical development? Contemporary Japan welcomes your submissions. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Genome editing in Streptococcus mutans through self‐targeting CRISPR arrays

Molecular Oral Microbiology, Volume 0, Issue ja, -Not available-.


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Use of multifilament nylon floss in onychocryptosis

Publication date: Available online 17 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Anuradha Bishnoi, Keshavamurthy Vinay, Sunil Dogra

https://ift.tt/2AiEboV

What do Patients Undergoing Mohs Micrographic Surgery Value? Results of a Patient Values Survey based on OAS-CAHPS

Publication date: Available online 17 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Paul R. Massey, Ruibin Wang, Simi D. Cadmus, Katherine R. Sebastian, Matthew C. Fox

https://ift.tt/2QYCcLH

FGFR3-related hypochondroplasia: longitudinal growth in 57 children with the p.Asn540Lys mutation

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


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The association of hs-CRP and fibrinogen with anthropometric and lipid parameters in non-obese adolescent girls with polycystic ovary syndrome

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


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A case of yellow chromonychia and yellow skin induced by topical ascorbic acid

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2NNNQqV

Combining topical tretinoin with mometasone furoate in the treatment of vulvar lichen sclerosus: Results of dermoscopic assessment

Dermatologic Therapy, EarlyView.


https://ift.tt/2Creh3Q

Evaluation of the scars’ vascularization using computer processing of the digital images

Skin Research and Technology, EarlyView.


https://ift.tt/2pXI903

Definition of psoriasis severity in routine clinical care: current guidelines fail to capture the complexity of long‐term psoriasis management

British Journal of Dermatology, EarlyView.


https://ift.tt/2PFWGbQ

Efficacy and safety of brodalumab in patients with psoriasis who had inadequate responses to ustekinumab: subgroup analysis of two randomized phase 3 trials

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2P6bK5E

5‐aminolevulinic acid nanoemulsion (BF‐200 ALA) is more effective than methyl‐5‐aminolevulinate (MAL) in daylight photodynamic therapy for actinic keratosis: A non‐sponsored randomized double‐blind multicentre trial

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2PG6rqK