PET/RM con 18F-colina en la sospecha de recurrencia del carcinoma de próstata

Publication date: Available online 22 May 2018
Source:Revista Española de Medicina Nuclear e Imagen Molecular
Author(s): C. Riola-Parada, J.L. Carreras-Delgado, V. Pérez-Dueñas, M. Garcerant-Tafur, L. García-Cañamaque
ObjetivoEvaluar la utilidad de la PET/RM con ¹⁸F-colina simultánea en la sospecha de recurrencia del carcinoma de próstata y relacionar su tasa de detección de enfermedad con variables analíticas y anatomopatológicas.Material y métodosEstudio retrospectivo de 27 pacientes con carcinoma de próstata que recibieron terapia local como tratamiento primario, a quienes se les realizó una PET/RM con ¹⁸F-colina por sospecha de recurrencia (elevación mantenida de los niveles de PSA). Los hallazgos patológicos de la PET/RM con ¹⁸F-colina fueron validados mediante el análisis anatomopatológico, otras pruebas de imagen o por la respuesta bioquímica al tratamiento oncológico.ResultadosLa PET/RM con ¹⁸F-colina detectó enfermedad en 15 de los 27 pacientes (tasa de detección del 55,56%); 4 (15%) presentaron recurrencia exclusivamente local, 5 (18%) metástasis ganglionares y 7 (26%) metástasis óseas. El PSA medio (PSAmed) a la realización del estudio fue de 2,94ng/mL (rango 0,18-10ng/mL). Los pacientes con PET/RM positiva presentaron un PSAmed de 3,70ng/mL (rango 0,24-10ng/mL), mayor que los pacientes con PET/RM negativa, PSAmed de 1,97ng/mL (rango 0,18-4,38ng/mL), aunque sin diferencias estadísticamente significativas. La puntuación Gleason al diagnóstico de los pacientes con estudio positivo fue de 7,33 (rango 6-9), y la de los pacientes con estudio negativo fue de 7 (rango 6-9), sin diferencias estadísticamente significativas.ConclusiónLa tasa de detección de la PET/RM con ¹⁸F-colina fue considerable pese a los valores relativamente bajos de PSA en nuestra muestra. La influencia de la puntuación Gleason y del nivel de PSA en la tasa de detección de la PET/RM con ¹⁸F-colina no fue estadísticamente significativa.ObjectiveTo evaluate the usefulness of simultaneous ¹⁸F-choline PET/MRI in the suspicion of prostate cancer recurrence and to relate ¹⁸F-choline PET/MRI detection rate with analytical and pathological variables.Material and methods27 patients with prostate cancer who received local therapy as primary treatment underwent a ¹⁸F-choline PET/MRI due to suspicion of recurrence (persistently rising serum PSA level). ¹⁸F-choline PET/MRI findings were validated by anatomopathological analysis, other imaging tests or by biochemical response to oncological treatment.Results¹⁸F-choline PET/MRI detected disease in 15 of 27 patients (detection rate 55.56%). 4 (15%) presented exclusively local recurrence, 5 (18%) lymph node metastases and 7 (26%) bone metastases. Mean PSA (PSAmed) at study time was 2.94ng/mL (range 0.18-10ng/mL). PSAmed in patients with positive PET/MRI was 3.70ng/mL (range 0.24-10ng/mL), higher than in patients with negative PET/MRI, PSAmed 1.97ng/mL (range 0.18-4.38ng/mL), although without statistically significant differences. Gleason score at diagnosis in patients with a positive study was 7.33 (range 6-9) and in patients with a negative study was 7 (range 6-9), without statistically significant differences.Conclusion¹⁸F-choline PET/MRI detection rate was considerable despite the relatively low PSA values in our sample. The influence of Gleason score and PSA level on ¹⁸F-choline PET/MRI detection rate was not statistically significant.



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Impact of genetic influence on serum total- and free 25-hydroxyvitamin-D in humans

Publication date: Available online 21 May 2018
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Balázs Szili, Boglárka Szabó, Péter Horváth, Bence Bakos, Györgyi Kirschner, János P. Kósa, Erzsébet Toldy, Zsuzsanna Putz, Péter Lakatos, Ádám Tabák, István Takács
Serum 25-hydroxyvitamin D /25OHD/ levels in humans are determined primarily by environmental factors such as UV-B radiation and diet, including vitamin D intake. Although some genetic determinants of 25OHD levels have been shown, the magnitude of this association has not yet been clarified. The present study evaluates the genetic contribution to total- /t-25OHD/ and free-25OHD /f-25OHD/ in a representative sample of the Hungarian population (n = 462). The study was performed at the end of winter to minimize the effect of sunlight, which is a major determinant of serum vitamin D levels. Single nucleotide polymorphisms (SNPs) of five genes playing major roles in vitamin D metabolism were investigated (NADSYN1, DHCR7, GC, CYP2R1 and CYP24A1). The selected SNPs account for 13.1% of the variance of t-25OHD levels. More than half of the genetic effect on t-25OHD levels was explained by two polymorphisms (rs7935125 in NADSYN1 and rs2762941 in CYP24A1), which had not previously been investigated with respect to vitamin D metabolism. No SNPs exhibited association with f-25OHD levels. Unexpectedly, SNPs that showed univariate associations with vitamin D binding protein (DBP) levels were not associated with f-25OHD levels questioning the biological significance of these polymorphisms.The present study shows that t-25OHD levels are significantly influenced by genetic factors, however, the clinical significance of this observation remains to be defined, as variation in f-25OHD levels are marginally explained by genetic effects.



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Basic red 2 and methyl violet adsorption by date pits: adsorbent characterization, optimization by RSM and CCD, equilibrium and kinetic studies

Abstract

The potential of raw date pits as a natural, widely available and low-cost agricultural waste has been studied in order to adsorb cationic dyes from an aqueous solution. Date pits were characterized by FTIR, SEM, BET, and XRD analysis. To optimize removal of two industrial dyes, basic red 2 (BR2) and methyl violet (MV), from aqueous solution using date pits, response surface methodology (RSM) is employed. Tests were carried out as per central composite design (CCD) with four input parameters namely contact time, temperature, initial concentration of adsorbate, and pH. Second-order polynomial model better fits experimental data for BR2 and MV and optimum values were then determined. In the optimum conditions, kinetic study was conducted and the pseudo-second-order model was found the best fitted model compared to pseudo-first-order model. Moreover, it was shown that intraparticle diffusion was not the sole controlling step and could be associated with other transfer resistance. On other hand, equilibrium isotherms were obtained for BR2 and MV and their maximum adsorption capacities were 92 and 136 mg g⁻¹ respectively. Two-parameter isotherm models like Langmuir, Temkin, Freundlich, Dubinin–Radushkevich, and Halsay were investigated to fit equilibrium data. Three error functions of residual root mean square error, chi-square statistic, and average relative error were used to comfort us in the selected models, which were actually Dubinin–Radushkevich and Langmuir for BR2 and Frendlich, Temkin, and Halsay for MV.

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Renoprotective effect of the isoflavonoid biochanin A against cisplatin induced acute kidney injury in mice: Effect on inflammatory burden and p53 apoptosis

Publication date: August 2018
Source:International Immunopharmacology, Volume 61
Author(s): Faiha A. Suliman, Dina M. Khodeer, Afaf Ibrahiem, Eman T. Mehanna, Mohamed K. El-Kherbetawy, Hala M.F. Mohammad, Sawsan A. Zaitone, Yasser M. Moustafa
Cisplatin is a potent widely-used chemotherapeutics; however, its clinical use is associated with nephrotoxicity. Renoprotective approaches are being discovered to halt the tubular cell death due to inflammatory and apoptotic burdens. In the present study, the renoprotective effects of different doses of biochanin A (10, 20 or 40 mg/kg) in mice treated with a single injection of cisplatin (10 mg/kg) were reported. Cisplatin administration resulted in marked increases in serum creatinine and blood urea nitrogen. Further, renal homogenates showed increased level of inflammatory cytokines and upregulation of the expression of p53 up-regulated modulator of apoptosis (PUMA), p53 and caspase 3 but downregulation in Nrf2 expression. Furthermore, cisplatin group showed marked necrosis and degenerated tubular lining epithelial cells with frequently detected apoptotic bodies. Mice treated with biochanin A (10, 20 or 40 mg/kg) for 14 days prior to cisplatin abrogated cisplatin-mediated damage. Furthermore, the elevated serum creatinine and urea levels were lessened by some doses of biochanin A, indicating protection against renal injury. Similarly, the changes in apoptosis and inflammatory markers have ameliorated to significant levels (P < 0.05). The results suggest biochanin A as a nephroprotective agent against cisplatin toxicity. Overall, this nephroprotective effect of biochanin A involved anti-inflammatory and antiapoptotic activities.



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Inhibition of acetaminophen-induced hepatotoxicity in mice by exogenous thymosinβ4 treatment

Publication date: August 2018
Source:International Immunopharmacology, Volume 61
Author(s): Lei Wang, Xiankui Li, Cai Chen
ObjectiveTo study the effects of exogenous thymosinβ4 (Tβ4) treatment in acetaminophen (APAP)-induced hepatotoxicity.MethodsLiver injury was induced in mice by a single intraperitoneal injection of APAP (500 mg/kg). Exogenous Tβ4 was intraperitoneally administrated at 0 h, 2 h and 4 h after APAP injection. Chloroquine (CQ) (60 mg/kg) was intraperitoneally injected 2 h before APAP administration to inhibit autophagy. Six hours after APAP injection liver injury was evaluated by histological examinations, biochemical measurements and enzyme linked immunosorbent assay (ELISAs). Western blots were performed to detect proteins expression.ResultsSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly increased 6 h after APAP administration, but were significantly reduced by co-administration of Tβ4. Histological examinations demonstrated that Tβ4 reduced necrosis and inflammation induced by APAP. Immunofluorescence showed that Tβ4 suppressed APAP-induced translocation of high mobility group box-1 protein (HMGB1) from the nucleus to cytosol and intercellular space. Hepatic glutathione (GSH) depletion, malondialdehyde (MDA) formation and decreased superoxide dismutase (SOD) activities induced by APAP were all attenuated by Tβ4. APAP-induced increases in hepatic nuclear factor-κB (NF-κB) p65 protein expression and inflammatory cytokines production including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were reduced by Tβ4 treatment. Increased LC3 and p62 proteins in the liver tissues of APAP-treated mice were decreased by Tβ4 treatment, which indicated the enhancement of autophagy flux by Tβ4. Furthermore, inhibiting autophagy by CQ abrogated the protective effects of Tβ4 against APAP hepatotoxicity.ConclusionExogenous Tβ4 treatment exerts protective effects against APAP-induced hepatotoxicity in mice. The underneath molecular mechanisms may involve autophagy enhancement and inhibition of oxidative stress by Tβ4.



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Rethinking the prescription of biotin for dermatologic conditions

Dermatologic Therapy, EarlyView.


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pH responsive label-assisted click chemistry triggered sensitivity amplification for ultrasensitive electrochemical detection of carbohydrate antigen 24-2

Publication date: 15 September 2018
Source:Biosensors and Bioelectronics, Volume 115
Author(s): Yun Zheng, Lihua Zhao, Zhanfang Ma
Sensitivity amplification strategy by implementing click chemistry in the construction of biosensing interface can efficiently improve the performance of immunosensor. Herein, we developed a sandwich-type amperometric immunosensor for ultrasensitive detection of carbohydrate antigen 24-2 (CA 242) based on pH responsive label-assisted click chemistry triggered sensitivity amplification strategy. The sensitivity of amperometric immunosensor relies on the current response differences (ΔI) caused by per unit concentration target analyte. The pH responsive Cu²⁺-loaded polydopamine (CuPDA) particles conjugated with detection antibodies were employed as labels, which can release Cu(II) ions by regulating pH. In the presence of ascorbic acid (reductant), Cu(II) ions were reduced to Cu(I) ions. Azide-functionalized double-stranded DNA (dsDNA) as signal enhancer was immobilized on the substrate through Cu⁺-catalyzed azide/alkyne cycloaddition reaction. With the help of the click reaction, the ΔI caused by target was elevated prominently, resulting in sensitivity amplification of the immunosensor. Under optimal condition, the proposed immunosensor exhibited excellent performance with linear range from 0.0001 to 100 U mL⁻¹ and ultralow detection limit of 20.74 μU mL⁻¹. This work successfully combines click chemistry with pH-responsive labels in sandwich-type amperometric immunosensor, providing a promising sensitivity amplification strategy to construct immunosensing platform for analysis of other tumor marker.



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CCTα Commands Phospholipid Homeostasis from the Nucleus

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Rosemary Cornell, Bruno Antonny
Enzyme control by their products facilitates cellular homeostasis, but for phospholipids, feedback mechanisms also arise from changes in membrane physical properties. In this issue of Developmental Cell, Haider et al. (2018) show that in many actively growing cells, an enzyme of phosphatidylcholine synthesis senses lipid packing in the nuclear membrane.

Teaser

Enzyme control by their products facilitates cellular homeostasis, but for phospholipids, feedback mechanisms also arise from changes in membrane physical properties. In this issue of Developmental Cell, Haider et al. (2018) show that in many actively growing cells, an enzyme of phosphatidylcholine synthesis senses lipid packing in the nuclear membrane.


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The Incredible Shrinking Spindle

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Christopher Brownlee, Rebecca Heald
As cell size decreases during the reductive divisions of early development, intracellular structures must shrink to fit. In this issue of Developmental Cell, Lacroix et al. (2018) identify a conserved mechanism of spindle scaling in nematode and sea urchin embryos whereby spindle microtubule polymerization rates decrease as development proceeds.

Teaser

As cell size decreases during the reductive divisions of early development, intracellular structures must shrink to fit. In this issue of Developmental Cell, Lacroix et al. (2018) identify a conserved mechanism of spindle scaling in nematode and sea urchin embryos whereby spindle microtubule polymerization rates decrease as development proceeds.


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Circuit Wiring: Neurite Speed Dating versus Stable Synaptic Matchmaking

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Heike Blockus, Franck Polleux
Understanding the mechanisms establishing the complex but precise pattern of connectivity characterizing neural circuits remains an immense challenge. In a recent issue of Neuron, Mao and colleagues (2018) provide new insights by showing that the activation kinetics of EphB2, a transmembrane receptor tyrosine kinase, control whether dendritic filopodia makes a synapse with candidate axons.

Teaser

Understanding the mechanisms establishing the complex but precise pattern of connectivity characterizing neural circuits remains an immense challenge. In a recent issue of Neuron, Mao and colleagues (2018) provide new insights by showing that the activation kinetics of EphB2, a transmembrane receptor tyrosine kinase, control whether dendritic filopodia makes a synapse with candidate axons.


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Pulmonary Neuroendocrine Cells: Sensors and Sentinels of the Lung

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Yoshihiko Kobayashi, Purushothama Rao Tata
Organisms have developed cellular "antennas" to sense, interpret, and integrate environmental stimuli. In a recent issue of Science, Sui et al. (2018) demonstrate that discrete clusters of pulmonary neuroendocrine cells in the lung can sense airborne allergens and relay signals to stimulate immune cells and induce tissue/organ-wide responses.

Teaser

Organisms have developed cellular "antennas" to sense, interpret, and integrate environmental stimuli. In a recent issue of Science, Sui et al. (2018) demonstrate that discrete clusters of pulmonary neuroendocrine cells in the lung can sense airborne allergens and relay signals to stimulate immune cells and induce tissue/organ-wide responses.


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Emerging Links between Lipid Droplets and Motor Neuron Diseases

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Giuseppa Pennetta, Michael A. Welte
Lipid droplets (LDs) are ubiquitous fat storage organelles and play key roles in lipid metabolism and energy homeostasis; in addition, they contribute to protein storage, folding, and degradation. However, a role for LDs in the nervous system remains largely unexplored. We discuss evidence supporting an intimate functional connection between LDs and motor neuron disease (MND) pathophysiology, examining how LD functions in systemic energy homeostasis, in neuron-glia metabolic coupling, and in protein folding and clearance may affect or contribute to disease pathology. An integrated understanding of LD biology and neurodegeneration may open the way for new therapeutic interventions.

Teaser

Lipid droplets (LDs) are ubiquitous fat storage organelles and play key roles in lipid metabolism and energy homeostasis; in addition, they contribute to protein storage, folding, and degradation. However, a role for LDs in the nervous system remains largely unexplored. We discuss evidence supporting an intimate functional connection between LDs and motor neuron disease (MND) pathophysiology, examining how LD functions in systemic energy homeostasis, in neuron-glia metabolic coupling, and in protein folding and clearance may affect or contribute to disease pathology. An integrated understanding of LD biology and neurodegeneration may open the way for new therapeutic interventions.


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Misshapen Connects Food, Mechanosensing, and Intestinal Growth

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Jin Jiang
Adult tissues such as intestinal epithelium can rapidly adapt their growth in response to environmental stimuli. In this issue of Developmental Cell, Li et al. (2018) demonstrate that gut epithelium stretching caused by food ingestion drives Drosophila intestinal growth via Hippo pathway regulation.

Teaser

Adult tissues such as intestinal epithelium can rapidly adapt their growth in response to environmental stimuli. In this issue of Developmental Cell, Li et al. (2018) demonstrate that gut epithelium stretching caused by food ingestion drives Drosophila intestinal growth via Hippo pathway regulation.


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Plasma Membrane Localization of Apoptotic Caspases for Non-apoptotic Functions

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Alla Amcheslavsky, Shiuan Wang, Caitlin E. Fogarty, Jillian L. Lindblad, Yun Fan, Andreas Bergmann
Caspases are best characterized for their function in apoptosis. However, they also have non-apoptotic functions such as apoptosis-induced proliferation (AiP), where caspases release mitogens for compensatory proliferation independently of their apoptotic role. Here, we report that the unconventional myosin, Myo1D, which is known for its involvement in left/right development, is an important mediator of AiP in Drosophila. Mechanistically, Myo1D translocates the initiator caspase Dronc to the basal side of the plasma membrane of epithelial cells where Dronc promotes the activation of the NADPH-oxidase Duox for reactive oxygen species generation and AiP in a non-apoptotic manner. We propose that the basal side of the plasma membrane constitutes a non-apoptotic compartment for caspases. Finally, Myo1D promotes tumor growth and invasiveness of the neoplastic scrib Ras^V12 model. Together, we identified a new function of Myo1D for AiP and tumorigenesis, and reveal a mechanism by which cells sequester apoptotic caspases in a non-apoptotic compartment at the plasma membrane.

Graphical abstract

Teaser

Amcheslavsky et al. provide a mechanism by which cells activate caspases without the detrimental consequences of apoptosis. In Drosophila, the unconventional myosin Myo1D localizes the initiator caspase Dronc to the basal side of the plasma membrane of epithelial cells. Here, Dronc can fulfill non-apoptotic functions such as apoptosis-induced proliferation.


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Microtubule Dynamics Scale with Cell Size to Set Spindle Length and Assembly Timing

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Benjamin Lacroix, Gaëlle Letort, Laras Pitayu, Jérémy Sallé, Marine Stefanutti, Gilliane Maton, Anne-Marie Ladouceur, Julie C. Canman, Paul S. Maddox, Amy S. Maddox, Nicolas Minc, François Nédélec, Julien Dumont
Successive cell divisions during embryonic cleavage create increasingly smaller cells, so intracellular structures must adapt accordingly. Mitotic spindle size correlates with cell size, but the mechanisms for this scaling remain unclear. Using live cell imaging, we analyzed spindle scaling during embryo cleavage in the nematode Caenorhabditis elegans and sea urchin Paracentrotus lividus. We reveal a common scaling mechanism, where the growth rate of spindle microtubules scales with cell volume, which explains spindle shortening. Spindle assembly timing is, however, constant throughout successive divisions. Analyses in silico suggest that controlling the microtubule growth rate is sufficient to scale spindle length and maintain a constant assembly timing. We tested our in silico predictions to demonstrate that modulating cell volume or microtubule growth rate in vivo induces a proportional spindle size change. Our results suggest that scalability of the microtubule growth rate when cell size varies adapts spindle length to cell volume.

Graphical abstract

Teaser

During early embryonic development, the mitotic spindle scales with decreasing cell size across successive reductive divisions. Lacroix et al. uncover, using in vivo and in silico analyses, a common scaling mechanism whereby spindle microtubule growth rate is coupled to cell volume for size scaling while maintaining constant spindle assembly timing.


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Tild-CRISPR Allows for Efficient and Precise Gene Knockin in Mouse and Human Cells

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Xuan Yao, Meiling Zhang, Xing Wang, Wenqin Ying, Xinde Hu, Pengfei Dai, Feilong Meng, Linyu Shi, Yun Sun, Ning Yao, Wanxia Zhong, Yun Li, Keliang Wu, Weiping Li, Zi-jiang Chen, Hui Yang
The targeting efficiency of knockin sequences via homologous recombination (HR) is generally low. Here we describe a method we call Tild-CRISPR (targeted integration with linearized dsDNA-CRISPR), a targeting strategy in which a PCR-amplified or precisely enzyme-cut transgene donor with 800-bp homology arms is injected with Cas9 mRNA and single guide RNA into mouse zygotes. Compared with existing targeting strategies, this method achieved much higher knockin efficiency in mouse embryos, as well as brain tissue. Importantly, the Tild-CRISPR method also yielded up to 12-fold higher knockin efficiency than HR-based methods in human embryos, making it suitable for studying gene functions in vivo and developing potential gene therapies.

Graphical abstract

Teaser

Yao et al. describe Tild-CRISPR, a targeting strategy using PCR-amplified or precisely enzyme-cut transgene donor sequence. Tild-CRISPR yields robust knockin efficiency in mouse and human embryos, as well as mouse brain in vivo, suitable for studying gene functions in vivo and developing potential gene therapies.


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Myonuclear Positioning and Aneurysms Are LINC’d by Ariadne

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Mridula Balakrishnan, Mary K. Baylies




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Scholar : Oncology Letters - Volume:15 Number:6

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TABLE OF CONTENTS June-2018 Volume 15 Issue 6

Recent advances in CD8+ regulatory T cell research (Review) Yating Yu, Xinbo Ma, Rufei Gong, Jianmeng Zhu, Lihua Wei, Jinguang Yao View Abstract ❯

Canine mammary tumors as a model for human disease (Review) Somaia M. Abdelmegeed, Sulma Mohammed View Abstract ❯

FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis Shinan Chen, Yan Qiu, Peng Guo, Tianjie Pu, Ye Feng, Hong Bu View Abstract ❯

Hypermethylation of protocadherin γ subfamily A12 and solute carrier family 19 A 1 promoters contributes to the occurrence and metastasis of colorectal cancer Cheng Zhang, Jinyun Li, Tao Huang, Cheng Chen, Qingxiao Hong, Huihui Ji, Meng Ye, Shiwei Duan View Abstract ❯

Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells Yajuan Hao, Jiawei Huang, Yun Ma, Wancheng Chen, Qin Fan, Xuegang Sun, Meng Shao, Hongbing Cai View Abstract ❯

Knockdown of stromal interaction molecule 1 inhibits proliferation of colorectal cancer cells by inducing apoptosis Dong Yang, Xiaoyu Dai, Keqiang Li, Yangyang Xie, Jianpei Zhao, Mingjun Dong, Hua Yu, Zhenfang Kong View Abstract ❯

LncRNA BX357664 inhibits cell proliferation and invasion and promotes cell apoptosis in human colorectal cancer cells Fengjun Liu, Xinsheng Wang, Haiyan Liu, Yang Wang, Xiaoqian Liu, Xiaochen Hao, Hongguang Li View Abstract ❯

Identification of key genes and pathways in meningioma by bioinformatics analysis Junxi Dai, Yanbin Ma, Shenghua Chu, Nanyang Le, Jun Cao, Yang Wang View Abstract ❯

TRIM59 induces epithelial‑to‑mesenchymal transition and promotes migration and invasion by PI3K/AKT signaling pathway in medulloblastoma Ran Gao, Guoqing Lv, Cuicui Zhang, Xiaoli Wang, Lijing Chen View Abstract ❯

Evaluation of the prognostic and physiological functions of death associated protein kinase 1 in breast cancer Yide Huang, Meizhen Lin, Xiangjin Chen, Chaoqun Huang, Xiuli Zhang, Ling Chen, Kunlin Wu, Yupeng Chen, Youzhi Zhu, Yao Lin View Abstract ❯

miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells Nadezhda Palkina, Anna Komina, Maria Aksenenko, Anton Moshev, Andrei Savchenko, Tatiana Ruksha View Abstract ❯

TMEM119 silencing inhibits cell viability and causes the apoptosis of gastric cancer SGC-7901 cells Peifen Zheng, Weifeng Wang, Muxi Ji, Qin Zhu, Yuliang Feng, Feng Zhou, Qiaona He View Abstract ❯

Effects of taxol resistance gene 1 on the cisplatin response in gastric cancer Shuquan Duan, Jie Yin, Zhigang Bai, Zhongtao Zhang View Abstract ❯

MicroRNA‑206 regulates the epithelial‑mesenchymal transition and inhibits the invasion and metastasis of prostate cancer cells by targeting Annexin A2 Ning Yang, Ling Wang, Jun Liu, Li Liu, Jiangbo Huang, Xian Chen, Zhigang Luo View Abstract ❯

miR-26a suppresses osteosarcoma migration and invasion by directly targeting HMGA1 Jianyong Liu, Bo Mi, Yi Wang, Chunling Shi, Xiufang Mi, Yingying Lu, Peilin Yu View Abstract ❯

miR‑133a, directly targeted USP39, suppresses cell proliferation and predicts prognosis of gastric cancer Xiang Dong, Hailong Su, Feng Jiang, Haiyan Li, Guangwen Shi, Lijuan Fan View Abstract ❯

Analysis of differential gene expression caused by cervical intraepithelial neoplasia based on GEO database Shenghui Yao, Taifeng Liu View Abstract ❯

Benzo(a)pyrene promotes Hep‑G2 cell migration and invasion by upregulating phosphorylated extracellular signal‑regulated kinase expression Yadong Wang, Teng Pan, Li Li, Haiyu Wang, Ding Zhang, Haiyan Yang View Abstract ❯

miR-100 inhibits the migration and invasion of nasopharyngeal carcinoma by targeting IGF1R Xiaoyan Sun, Xiaoying Liu, Yanmei Wang, Shuqin Yang, Yao Chen, Tiejun Yuan View Abstract ❯

Effects of compound K, an enteric microbiome metabolite of ginseng, in the treatment of inflammation associated colon cancer Haiqiang Yao, Jin‑Yi Wan, Jinxiang Zeng, Wei‑Hua Huang, Clara Sava‑Segal, Lingru Li, Xin Niu, Qi Wang, Chong‑Zhi Wang, Chun‑Su Yuan View Abstract ❯

Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI Weiwei Zhao, Zhiyong Quan, Xufang Huang, Jing Ren, Didi Wen, Guangwen Zhang, Zhongqiang Shi, Hong Yin, Yi Huan View Abstract ❯

FPOA induces apoptosis in HeLa human cervical cancer cells through a caspase‑mediated pathway Xin Li, Tolgor Bau, Haiying Bao View Abstract ❯

lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer Qing Li, Juan Zhang, Juan Zhou, Binglie Yang, Pingping Liu, Lei Cao, Lei Jing, Hua Liu View Abstract ❯

Gene‑gene interaction network analysis of hepatocellular carcinoma using bioinformatic software Jin‑Hua He, Ze‑Ping Han, Pu‑Zhao Wu, Mao‑Xian Zou, Li Wang, Yu‑Bing Lv, Jia‑Bin Zhou, Ming‑Rong Cao, Yu‑Guang Li View Abstract ❯

Human corticotrophin releasing factor inhibits cell proliferation and promotes apoptosis through upregulation of tumor protein p53 in human glioma Yan Feng, Liqun Wang, Xin Liu, Qiang Wu, Haofeng Zhang, Fuguang Hu, Xiaofeng Sun View Abstract ❯

Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile Hailong Liang, Xiangyang Chu, Jing Zhao, Guosheng Xing, Yingjian Si View Abstract ❯

Significance of PIVKA‑II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus‑associated hepatocellular carcinoma Xiao‑Lu Ma, Jing Zhu, Jiong Wu, Lu Tian, Yao‑Yi Gao, Chun‑Yan Zhang, Yan Zhou, Qian Dai, Bei‑Li Wang, Bai‑Shen Pan, Jian Zhou, Jia Fan, Xin‑Rong Yang, Wei Guo View Abstract ❯

Overexpression of dihydrofolate reductase is a factor of poor survival in acute lymphoblastic leukemia Jorge Organista‑Nava, Yazmín Gómez‑Gómez, Berenice Illades‑Aguiar, Ana Bertha Rivera‑Ramírez, Mónica Virginia Saavedra‑Herrera, Marco Antonio Leyva‑Vázquez View Abstract ❯

Effects of miR-126 on the STAT3 signaling pathway and the regulation of malignant behavior in lung cancer cells Zaiyun Zhang, Jihua Wang, Jian Cheng, Xiaoming Yu View Abstract ❯

Functional analysis of gene expression profiling‑based prediction in bladder cancer Ji‑Ping Wang, Ji‑Yan Leng, Rong‑Kui Zhang, Li Zhang, Bei Zhang, Wen‑Yan Jiang, Lan Tong View Abstract ❯

Long non‑coding RNA H19 regulates viability and metastasis, and is upregulated in retinoblastoma Li Li, Wei Chen, Yuchuan Wang, Luosheng Tang, Mei Han View Abstract ❯

microRNA‑23a promotes cell growth and metastasis in gastric cancer via targeting SPRY2‑mediated ERK signaling Yingjia Li, Hui Chen, Pengfei She, Ti Chen, Lihua Chen, Jinling Yuan, Botao Jiang View Abstract ❯

Fisetin inhibits the proliferation of gastric cancer cells and induces apoptosis through suppression of ERK 1/2 activation Weixin Yan, Shouhui Chen, Yiyang Zhao, Xiaoyu Ye View Abstract ❯

Cronkhite‑Canada syndrome: A case report Wei Yuan, Li Tian, Fei‑Yan Ai, Shao‑Jun Liu, Shou‑Rong Shen, Xiao‑Yan Wang, Fen Liu View Abstract ❯

Effects of aspirin on proliferation, invasion and apoptosis of Hep‑2 cells via the PTEN/AKT/NF‑κB/survivin signaling pathway Mingji Jin, Chunyu Li, Qiang Zhang, Shu Xing, Xuan Kan, Jiayu Wang View Abstract ❯

Aberrant promoter methylation status is associated with upregulation of the E2F4 gene in breast cancer Farman Ullah Farman, Farhan Haq, Noor Muhammad, Nawab Ali, Hazir Rahman, Muhammad Saeed View Abstract ❯

Tunicamycin inhibits progression of glioma cells through downregulation of the MEG‑3‑regulated wnt/β‑catenin signaling pathway Xin Li, Lei Xue, Qin Peng View Abstract ❯

Axillary ultrasound and fine needle aspiration biopsy in the preoperative diagnosis of axillary metastases in early‑stage breast cancer Xin Hu, Xiao Zhou, Huawei Yang, Wei Wei, Yi Jiang, Jianlun Liu View Abstract ❯

Increased H2S and its synthases in urothelial cell carcinoma of the bladder, and enhanced cisplatin‑induced apoptosis following H2S inhibition in EJ cells Wasilijiang Wahafu, Junwei Gai, Liming Song, Hao Ping, Mingshuai Wang, Feiya Yang, Yinong Niu, Nianzeng Xing View Abstract ❯

Identification of potential pathogenic biomarkers in clear cell renal cell carcinoma Zengzeng Wang, Zhihong Zhang, Changwen Zhang, Yong Xu View Abstract ❯

Application value of CT and MRI in diagnosis of primary brain lymphoma Yongchun Qin, Aihua Bao, Hongjun Li, Xin Wang, Ge Zhang, Jiafeng Zhu View Abstract ❯

Mechanisms for enhanced antitumor immune responses induced by irradiated hepatocellular carcinoma cells engineered to express hepatitis B virus X protein Anliang Huang, Jinhu Ma, Liyan Huang, Fan Yang, Ping Cheng View Abstract ❯

In vitro analysis of putative cancer stem cell populations and chemosensitivity in the SW480 and SW620 colon cancer metastasis model Cindy Slater, Jo‑Anne de La Mare, Adrienne Lesley Edkins View Abstract ❯

∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer Yingzhi Zhang, Wei Zheng, Kewei Shen, Weiwei Shen View Abstract ❯

Suppression of tumor cell proliferation and migration by human umbilical cord mesenchymal stem cells: A possible role for apoptosis and Wnt signaling Yin Yuan, Chang Zhou, Xuan Chen, Changli Tao, Huiqing Cheng, Xin Lu View Abstract ❯

Identification of subtype‑specific prognostic signatures using Cox models with redundant gene elimination Suyan Tian View Abstract ❯

The expression of HOXA13 in lung adenocarcinoma and its clinical significance: A study based on The Cancer Genome Atlas, Oncomine and reverse transcription‑quantitative polymerase chain reaction Yun Deng, Rongquan He, Rui Zhang, Binliang Gan, Yu Zhang, Gang Chen, Xiaohua Hu View Abstract ❯

Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion Qian‑Cheng Zhou, Xue‑Feng Deng, Juan Yang, Hong Jiang, Ming‑Xu Qiao, Huan‑Huan Liu, Zhen Qian, Ling‑Ling Hou, Hong‑Gang Hu View Abstract ❯

Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway Meng‑Ting Chen, He‑Fen Sun, Liang‑Dong Li, Yang Zhao, Li‑Peng Yang, Shui‑Ping Gao, Wei Jin View Abstract ❯

Patient‑derived tumor xenografts of lung squamous cell carcinoma alter long non‑coding RNA profile but not responsiveness to cisplatin Dapeng Lu, Peng Luo, Ju Zhang, Yuanyuan Ye, Qi Wang, Ming Li, Hangcheng Zhou, Mingran Xie, Baolong Wang View Abstract ❯

Analysis of the clinicopathological features and prognostic factors of primary hepatic neuroendocrine tumors Ren‑Wang Chen, Meng‑Jun Qiu, Yaobing Chen, Tao Zhang, Xiao‑Xiao He, Ying Li, Wen‑Jia Sun, Tao Xie, Sheng‑Li Yang, Jian‑Li Hu View Abstract ❯

Clinicopathological significance of G9A expression in colorectal carcinoma Jian Qin, Zhi Zeng, Tao Luo, Qingyun Li, Yarong Hao, Lang Chen View Abstract ❯

Long non‑coding RNA AFAP1‑antisense RNA 1 promotes the proliferation, migration and invasion of gastric cancer cells and is associated with poor patient survival Huazhou Zhao, Kecheng Zhang, Ting Wang, Jianxin Cui, Hongqing Xi, Yi Wang, Yanjing Song, Xudong Zhao, Bo Wei, Lin Chen View Abstract ❯

Effects of peritumoral bevacizumab injection against oral squamous cell carcinoma in a nude mouse xenograft model: A preliminary study Hisato Yoshida, Hitoshi Yoshimura, Shinpei Matsuda, Takashi Ryoke, Tamotsu Kiyoshima, Motohiro Kobayashi, Kazuo Sano View Abstract ❯

Effects of modified FOLFOX-6 chemotherapy on cellular immune function in patients with gastric cancer Liang Wang, Donger Zhou, Haitao Ren, Yan Chen View Abstract ❯

Expression of long‑chain fatty acid receptor GPR40 is associated with cancer progression in colorectal cancer: A retrospective study Chie Nakashima, Kishi Shingo, Rina Fujiwara‑Tani, Yi Luo, Isao Kawahara, Kei Goto, Takamitsu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Hiroki Kuniyasu View Abstract ❯

Examination of the use of needle biopsy to perform laparoscopic surgery safely on uterine smooth muscle tumors Makoto Murakami, Tomoyuki Ichimura, Mari Kasai, Makiko Matsuda, Naoki Kawamura, Takeshi Fukuda, Toshiyuki Sumi View Abstract ❯

Growth pattern change of a benign clear cell 'sugar' tumor of the lung: Serial imaging surveillance over seven years Eung Koo Yeon, Jung Im Kim, Kyu Yeoun Won, Han Na Lee View Abstract ❯

Endoscopic analysis of colorectal serrated lesions with cancer Shuichiro Nagata, Keiichi Mitsuyama, Hiroshi Kawano, Tetsuhiro Noda, Yasuhiko Maeyama, Michita Mukasa, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Jun Akiba, Osamu Tsuruta, Takuji Torimura View Abstract ❯

Acute lymphoblastic leukemia following temozolomide treatment in a patient with glioblastoma: A case report and review of the literature Pengfei Liu, Peiwen Li, Ting Lei, Limei Qu, Haiyan Huang, Qingchun Mu View Abstract ❯

Forkhead‑box series expression network is associated with outcome of clear‑cell renal cell carcinoma Zhongwei Jia, Fangning Wan, Yao Zhu, Guohai Shi, Hailiang Zhang, Bo Dai, Dingwei Ye View Abstract ❯

Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells Jiehong Zeng, Zhengkai Liu, Shuwen Sun, Jianhong Xie, Li Cao, Pin Lv, Shengdan Nie, Bao Zhang, Bowen Xie, Siyuan Peng, Bo Jiang View Abstract ❯

Regulatory mechanism of microRNA‑128 in osteosarcoma tumorigenesis and evolution through targeting SASH1 Zi Li, Jiangdong Ni, Deye Song, Muliang Ding View Abstract ❯

Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins Yateng Tie, Chong Chen, Yanli Yang, Zhen Qian, Hang Yuan, Huan Wang, Haili Tang, Yao Peng, Xilin Du, Bin Liu View Abstract ❯

A real‑world study of treatment patterns and survival outcome in advanced anaplastic lymphoma kinase‑positive non‑small‑cell lung cancer Ying Jin, Yamei Chen, Xinmin Yu, Xun Shi View Abstract ❯

Asiatic acid prevents the development of interstitial lung disease in a hypochlorous acid‑induced mouse model of scleroderma Xiaoru Xia, Caijun Dai, Hua Yu, Xiaoying Huang, Ali Chen, Yingxia Tan, Liangxing Wang View Abstract ❯

Treatment of hepatic metastases with computed tomography‑guided interstitial brachytherapy Dariusz Kieszko, Paweł Cisek, Izabela Kordzińska‑Cisek, Ludmiła Grzybowska‑Szatkowska View Abstract ❯

Transforming growth factor‑β decreases side population cells in hepatocellular carcinoma in vitro Jong Bin Kim, Seulki Lee, Hye Ri Kim, Seo‑Young Park, Minjong Lee, Jung‑Hwan Yoon, Yoon Jun Kim View Abstract ❯

The roles of RUNX3 in cervical cancer cells in vitro Zhen Li, Pan Fan, Min Deng, Chao Zeng View Abstract ❯

Low tumor glutathione level as a sensitivity marker for glutamate‑cysteine ligase inhibitors Satoru Nishizawa, Hideo Araki, Yoshinori Ishikawa, Satoshi Kitazawa, Akito Hata, Tomoyoshi Soga, Takahito Hara View Abstract ❯

miR‑137 suppresses proliferation, migration and invasion of colon cancer cell lines by targeting TCF4 Wei‑Ping Bi, Min Xia, Xin‑Jian Wang View Abstract ❯

The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer Jing‑Wei Wang, Xiao‑Long Wei, Xiao‑Wei Dou, Wen‑He Huang, Cai‑Wen Du, Guo‑Jun Zhang View Abstract ❯

Effect of allyl isothiocyanate on the viability and apoptosis of the human cervical cancer HeLa cell line in vitro Guangyi Qin, Ping Li, Zhuowei Xue View Abstract ❯

Knockdown of serine/threonine protein phosphatase 5 enhances gemcitabine sensitivity by promoting apoptosis in pancreatic cancer cells in vitro Jinhui Zhu, Yun Ji, Yuanquan Yu, Yun Jin, Xiaoxiao Zhang, Jiale Zhou, Yan Chen View Abstract ❯

Combined treatment with sinomenine and acupuncture on collagen‑induced arthritis through the NF‑κB and MAPK signaling pathway Minmin Xu, Shaofan Liu, Ruijie Wan, Yu Chen View Abstract ❯

MAGE3 and Survivin activated dendritic cell immunotherapy for the treatment of non-small cell lung cancer Dong Li, Song He View Abstract ❯

Downregulation of RIP140 in triple‑negative breast cancer inhibits the growth and proliferation of cancer cells Xiao‑Hong Yu, Xiaodong Xue, Xun Zhu, Xia Li View Abstract ❯

High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer Yan Zhang, Jiaxuan Zhang, Qin Shen, Wei Yin, Hua Huang, Yifei Liu, Qingfeng Ni View Abstract ❯

Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer Wen‑Liang Qiao, Bo‑Wen Shi, Yu‑Dong Han, Hua‑Mei Tang, Jun Lin, Hai‑Yang Hu, Qiang Lin View Abstract ❯

Identification and functional characterization of long non-coding RNAs in human gastric cancer Cheng‑Yun Li, Ge‑Yu Liang, Wen‑Zhuo Yao, Jing Sui, Xian Shen, Yan‑Qiu Zhang, Shu‑Mei Ma, Yan‑Cheng Ye, Zhi‑Yi Zhang, Wen‑Hua Zhang, Li‑Hong Yin, Yue‑Pu Pu View Abstract ❯

miR‑19 in blood plasma reflects lung cancer occurrence but is not specifically associated with radon exposure Olga Bulgakova, Dinara Zhabayeva, Assiya Kussainova, Alessandra Pulliero, Alberto Izzotti, Rakhmetkazhi Bersimbaev View Abstract ❯

Magnetic resonance features of meningeal solitary fibrous tumors Xi Li, Lilian Tan, Xiaoming Ouyang, Jindai Jiang, Sumeng Huang, Yong Huang, Shuxin Li, Deji Chen View Abstract ❯

HOXB13 expression and promoter methylation as a candidate biomarker in gastric cancer Bai‑Qiang Sui, Chun‑Dong Zhang, Ji‑Chao Liu, Lei Wang, Dong‑Qiu Dai View Abstract ❯

Miltirone‑induced apoptosis in cisplatin‑resistant lung cancer cells through upregulation of p53 signaling pathways Zhongcheng Zhu View Abstract ❯

Tumor necrosis factor receptor 2 may promote the proliferation and drug resistance of Kapras299 and L428 lymphoma cells via the AKT and WNT/β‑catenin signaling pathways Yanyan Liang, Yu Wang, Meng Xiao, Yunliang Hao, Yongtian Zhang, Shumei Li View Abstract ❯

Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer Huan Wang, Xiao‑Ming Xing, Lei‑Na Ma, Lian Liu, Jing Hao, Ling‑Xin Feng, Zhuang Yu View Abstract ❯

Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma Ana Isabel Plano Sánchez, Lucía Velasco Roces, Isabel Zapico García, Eva Lázaro López, Miguel Angel Calleja Hernandez, Maria Isabel Baena Parejo, Jaime Peña‑Díaz View Abstract ❯

Chloroform fraction of Serratulae chinensis S. Moore suppresses proliferation and induces apoptosis via the phosphatidylinositide 3‑kinase/Akt pathway in human gastric cancer cells Qiaoyan Cai, Jing Lin, Ling Zhang, Shan Lin, Jun Peng View Abstract ❯

3F‑Box protein 32 degrades ataxia telangiectasia and Rad3‑related and regulates DNA damage response induced by gemcitabine in pancreatic cancer Chong Yang, Ping Fan, Shikai Zhu, Hongji Yang, Xin Jin, Heshui Wu View Abstract ❯

[Corrigendum] Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Ariundavaa Boldbaatar, Sunyi Lee, Sora Han, Ae Lee Jeong, Hye In Ka, Sumiyasuren Buyanravjikh, Jeong Hyung Lee, Jong‑Seok Lim, Myung Sok Lee, Young Yang View Abstract ❯

F‑box proteins involved in cancer‑associated drug resistance (Review) Jian Gong, Yuqian Zhou, Deliang Liu, Jirong Huo View Abstract ❯

Primary tumours of the calcaneus (Review) Litao Yan, Junwei Zong, Jin Chu, Wendong Wang, Mingshu Li, Xianfeng Wang, Mingzhi Song, Shouyu Wang View Abstract ❯

Clinical significance of blood‑based miRNAs as biomarkers of non‑small cell lung cancer (Review) Lin Li, Yu Sun, Min Feng, Liang Wang, Jing Liu View Abstract ❯

Research progress on the anticancer effects of vitamin K2 (Review) Fan Xv, Jiepeng Chen, Lili Duan, Shuzhuang Li View Abstract ❯

Phosphoglycerate mutase 1 is highly expressed in C6 glioma cells and human astrocytoma Zhi‑Guo Liu, Jie Ding, Chuan Du, Ning Xu, En‑Le Wang, Jian‑Yi Li, Yun‑Yan Wang, Jin‑Ming Yu View Abstract ❯

MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells Qinghua Huang, Qunying Ma View Abstract ❯

Association between circadian gene CLOCK and cisplatin resistance in ovarian cancer cells: A preliminary study Hai Xu, Zhiyin Wang, Guoyan Mo, Hao Chen View Abstract ❯

Low accuracy of chromogranin A for diagnosing early‑stage pancreatic neuroendocrine tumors Chao‑Ming Tseng, Tsu‑Yao Cheng, Tai‑Been Chen, Yu‑Wen Tien, Chien‑Chuan Chen, Jaw‑Town Lin, Hsiu‑Po Wang View Abstract ❯

Identification of circulating tumor cells with EML4‑ALK translocation using fluorescence in situ hybridization in advanced ALK‑positive patients with lung cancer Young Hun Kim, Eunjoo Hwang, Hye Seon Lee, Ji‑Hyun Uh, Myoung Shin Kim, Byung Hee Jeon View Abstract ❯

Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions Liang Zhao, Zhechao Zhang, Hongyan Lou, Jingjing Liang, Xiaojian Yan, Wenfeng Li, Yunsheng Xu, Rongying Ou View Abstract ❯

XAV939 inhibits the proliferation and migration of lung adenocarcinoma A549 cells through the WNT pathway Chong Li, Xu Zheng, Yanyan Han, Yan Lv, Fu Lan, Jie Zhao View Abstract ❯

Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis Xuehai Wang, Gang Li, Qingsong Luo, Chongzhi Gan View Abstract ❯

Bcl‑2 promotes metastasis through the epithelial‑to‑mesenchymal transition in the BCap37 medullary breast cancer cell line Chengyong Du, Xiaochen Zhang, Minya Yao, Kezhen Lv, Jiannan Wang, Luyan Chen, Yaomin Chen, Shuqian Wang, Peifen Fu View Abstract ❯

Significance of calreticulin as a prognostic factor in endometrial cancer Qin Xu, Chuanben Chen, Guilin Chen, Wei Chen, Dongmei Zhou, Yunqing Xie View Abstract ❯

B‑cell lymphoma 2 is associated with advanced tumor grade and clinical stage, and reduced overall survival in young Chinese patients with colorectal carcinoma Jiasheng Wang, Gan He, Qiang Yang, Lian Bai, Bin Jian, Qugang Li, Zhongfu Li View Abstract ❯

Hypermethylation of MDFI promoter with NSCLC is specific for females, non‑smokers and people younger than 65 Hongying Ma, Xiaoying Chen, Haochang Hu, Bin Li, Xiuru Ying, Cong Zhou, Jie Zhong, Guofang Zhao, Shiwei Duan View Abstract ❯

Inhibition of lysine‑specific demethylase 1 prevents proliferation and mediates cisplatin sensitivity in ovarian cancer cells Genbao Shao, Xiaolei Wan, Wensheng Lai, Chaoyang Wu, Jie Jin, Xiuwen Liu, Ye Wei, Qiong Lin, Liuping Zhang, Qixiang Shao View Abstract ❯

CD63 inhibits the cell migration and invasion ability of tongue squamous cell carcinoma Wen‑Hui Liu, Xin Li, Xin‑Ling Zhu, Mei‑Ling Hou, Wei Zhao View Abstract ❯

Epigenetic inactivation of galanin receptors in salivary duct carcinoma of the parotid gland: Potential utility as biomarkers for prognosis Takeharu Kanazawa, Kiyoshi Misawa, Hirofumi Fukushima, Yuki Misawa, Yukiko Sato, Mikiko Maruta, Shoichiro Imayoshi, Gen Kusaka, Kazuyoshi Kawabata, Hiroyuki Mineta, Thomas E. Carey, Hiroshi Nishino View Abstract ❯

MicroRNA‑126 inhibits proliferation and metastasis in prostate cancer via regulation of ADAM9 Yibo Hua, Chao Liang, Chenkui Miao, Shangqian Wang, Shifeng Su, Pengfei Shao, Bianjiang Liu, Meiling Bao, Jundong Zhu, Aiming Xu, Jianzhong Zhang, Jie Li, Zengjun Wang View Abstract ❯

Effect of membrane‑bound complement regulatory proteins on tumor cell sensitivity to complement‑dependent cytolysis triggered by heterologous expression of the α‑gal xenoantigen Yu Wang, Juan Liao, Ya‑Jun Yang, Zhu Wang, Feng Qin, Sheng‑Ming Zhu, Hong Zheng, Yan‑Ping Wang View Abstract ❯

PRL‑3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway in vitro and in vivo Yang Zhang, Zhengrong Li, Xiaole Fan, Jianbo Xiong, Guoyang Zhang, Xianshi Luo, Kun Li, Zhigang Jie, Yi Cao, Zuoxi Huang, Feng Wu, Lin Xiao, Guangling Duan, Heping Chen View Abstract ❯

CD47 as a potential prognostic marker for oral leukoplakia and oral squamous cell carcinoma Xiaojing Ye, Xiaojun Wang, Rui Lu, Jing Zhang, Xinming Chen, Gang Zhou View Abstract ❯

miR‑96 promotes invasion and metastasis by targeting GPC3 in non‑small cell lung cancer cells Xiubin Fei, Jingang Zhang, Yunwei Zhao, Meijia Sun, Haifeng Zhao, Shuang Li View Abstract ❯

A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report Junya Kobayashi, Daisuke Fujimoto, Makoto Murakami, Yasuo Hirono, Takanori Goi View Abstract ❯

Targeted therapy of triple negative MDA‑MB‑468 breast cancer with curcumin delivered by epidermal growth factor‑conjugated phospholipid nanoparticles Kyung‑Ho Jung, Jin Hee Lee, Jin Won Park, Da Hae Kim, Seung‑Hwan Moon, Young Seok Cho, Kyung‑Han Lee View Abstract ❯

miR‑888 functions as an oncogene and predicts poor prognosis in colorectal cancer Su‑Jun Gao, Lei Chen, Wei Lu, Li Zhang, Lu Wang, Hai‑Hang Zhu View Abstract ❯

Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients Xiangming Ma, Yunlong Cui, Hongyuan Zhou, Qiang Li View Abstract ❯

Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells Yi Xu, Yanyue Tong, Junjie Ying, Zhangming Lei, Lijun Wan, Xiuwen Zhu, Feng Ye, Penglei Mao, Xinkuan Wu, Renbing Pan, Bo Peng, Yukun Liu, Jianyong Zhu View Abstract ❯

MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation Liming Wu, Feibiao Yang, Bingyi Lin, Xinhua Chen, Shengyong Yin, Feng Zhang, Haiyang Xie, Lin Zhou, Shusen Zheng View Abstract ❯

Bioinformatics and functional analyses of key genes and pathways in human clear cell renal cell carcinoma Jinxing Wang, Lushun Yuan, Xingnian Liu, Gang Wang, Yuan Zhu, Kaiyu Qian, Yu Xiao, Xinghuan Wang View Abstract ❯

Tumor‑derived mesenchymal‑stem‑cell‑secreted IL‑6 enhances resistance to cisplatin via the STAT3 pathway in breast cancer Huitao Xu, Ying Zhou, Wei Li, Bin Zhang, Huanhuan Zhang, Shaolin Zhao, Ping Zheng, Huiyi Wu, Jin Yang View Abstract ❯

Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma Kui Zhao, Xiaoxu Li, Jiongke Wang, Jiajia Liu, Wang Gong, Hao Xu, Jiayi Wang, Lu Jiang, Hongxia Dan, Jing Li, Xin Zeng, Qianming Chen View Abstract ❯

Clinical significance of expression levels of serum ADRA1A in hysterocarcinoma patients Lin Peng, Wei Peng, Peng Hu, Hui-Feng Zhang View Abstract ❯

Molecular dynamic simulation of mutated β‑catenin in solid pseudopapillary neoplasia of the pancreas Varomyalin Tipmanee, Nawanwat C. Pattaranggoon, Kanet Kanjanapradit, Jirakrit Saetang, Surasak Sangkhathat View Abstract ❯

Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience Cristina Romei, Alessia Tacito, Eleonora Molinaro, Paolo Piaggi, Virginia Cappagli, Letizia Pieruzzi, Antonio Matrone, David Viola, Laura Agate, Liborio Torregrossa, Clara Ugolini, Fulvio Basolo, Luigi De Napoli, Michele Curcio, Raffaele Ciampi, Gabriele Materazzi, Paolo Vitti, Rossella Elisei View Abstract ❯

Aberrant expression of miR‑153 is associated with the poor prognosis of cervical cancer Li Liu, Xiaojing Lai, Changjin Yuan, Xiuwei Lv, Tao Yu, Wenyu He, Jiaoping Liu, Haiming Zhang View Abstract ❯

High NUCB2 expression level is associated with metastasis and may promote tumor progression in colorectal cancer Jun Xie, Lina Chen, Wenbin Chen View Abstract ❯

Nicotinamide N‑methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1 Zhenyu You, Yang Liu, Xuefei Liu View Abstract ❯

Suppression of CCT3 inhibits malignant proliferation of human papillary thyroid carcinoma cell Xiaohui Shi, Suisheng Cheng, Weixing Wang View Abstract ❯

miR‑371‑5p suppresses the proliferative and migratory capacity of human nasopharyngeal carcinoma by targeting BCL2 Bifan Deng, Feiqun Su, Ruibin Xie, Weiguang Tang View Abstract ❯

Expression patterns of E2F transcription factors and their potential prognostic roles in breast cancer Yunhai Li, Jing Huang, Dejuan Yang, Shili Xiang, Jiazheng Sun, Hongzhong Li, Guosheng Ren View Abstract ❯

Bacillus Calmette‑Guérin induces rapid gene expression changes in human bladder cancer cell lines that may modulate its survival Juwita N. Rahmat, Kesavan Esuvaranathan, Ratha Mahendran View Abstract ❯

Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial‑mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway Xiancong Bu, Xiangyan Zhang, Jinhong Xu, Heping Yang, Xiangdong Zhou, Haijing Wang, Liang Gong View Abstract ❯

Cisplatin‑induced non‑canonical endocytosis of EGFR via p38 phosphorylation of the C‑terminal region containing Ser‑1015 in non‑small cell lung cancer cells Tomohiro Tanaka, Tatsuhiko Ozawa, Eiji Oga, Atsushi Muraguchi, Hiroaki Sakurai View Abstract ❯

CD57 ratio as a convenient and useful immunological and prognostic parameter for stage IV carcinoma Junji Akagi, Hideo Baba View Abstract ❯

Long non‑coding RNA NNT‑AS1 contributes to cell proliferation, metastasis and apoptosis in human ovarian cancer Yaqing Huang, Junyu Shi, Yun Xu View Abstract ❯

Combined caveolin‑1 and epidermal growth factor receptor expression as a prognostic marker for breast cancer Ya‑Nan Liang, Yu Liu, Letian Wang, Guodong Yao, Xiaobo Li, Xiangning Meng, Fan Wang, Ming Li, Dandan Tong, Jingshu Geng View Abstract ❯

World Health Organization type B2 thymoma with an abundance of Hassall's corpuscles: A case report Li Gong, Lu Sun, Chenling Zhang, Sanhua Wei, Jun Chen, Yazhuo Li, Yanhong Li, Wei Zhang, Yongsheng Zhang View Abstract ❯

Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients Wei Liu, Yanmiao Huo, Jianyu Yang, Xueliang Fu, Minwei Yang, Lingye Tao, Dejun Liu, Junfeng Zhang, Rong Hua, Yongwei Sun View Abstract ❯

Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer Licheng Xu, Zhi Liang, Shuyan Li, Jianjun Ma View Abstract ❯

Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep‑2 cells Hong Gao, Hai Dong, Guijun Li, Hui Jin View Abstract ❯

Serum peptide expression and treatment responses in patients with advanced non‑small‑cell lung cancer Juan An, Chuan‑Hao Tang, Na Wang, Yi Liu, Jin Lv, Bin Xu, Xiao‑Yan Li, Wan‑Feng Guo, Hong‑Jun Gao, Kun He, Xiao‑Qing Liu View Abstract ❯

Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma Xuemei Du, Ying Gao, Hongyu Zhao, Bin Li, Weimin Xue, Daye Wang View Abstract ❯

Utility of intraoperative monitoring with motor‑evoked potential during the surgical enucleation of peripheral nerve schwannoma Hiromi Sasaki, Satoshi Nagano, Masahiro Yokouchi, Takao Setoguchi, Hirofumi Shimada, Takuya Yamamoto, Yasuhiro Ishidou, Setsuro Komiya View Abstract ❯

DNA damage regulated autophagy modulator 1 recovers the function of apoptosis‑stimulating of p53 protein 2 on inducing apoptotic cell death in Huh7.5 cells Dongjie Liu, Rui Li, Xianghua Guo, Lijun Pang, Yunjin Zang, Kai Liu, Dexi Chen View Abstract ❯

Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells by inhibiting the activation of the mTOR/p70S6K pathway Yan Ding, Wei Liu, Xiaoling Wang, Lingling Zhang, Meng Zhao, Huiyan Deng, Yueping Liu View Abstract ❯

High levels of centrosomal protein 55 expression is associated with poor clinical prognosis in patients with cervical cancer Jingyi Qi, Gelin Liu, Fang Wang View Abstract ❯

Association between 5‑lipoxygenase expression, and malignant behaviors and poor prognosis in esophageal squamous cell carcinoma Chun‑Ying Bai, Jun‑Yi Zhang, Tie‑Wei Shi, Yu‑Qin Bai, Bing‑Li Wu, Ze‑Peng Du, Zhi‑Yong Wu, Xiu‑E Xu, Shao‑Hong Wang, Jian‑Yi Wu, Rui‑Yun Te, Jing‑Yi Zhang, Li‑Yan Xu, En‑Min Li View Abstract ❯

Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis Yuqin Zang, Lina Gu, Yanfang Zhang, Yingmei Wang, Fengxia Xue View Abstract ❯

Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological significance Yanping Liu, Han Sun, Hongju Mao, Meng Gao, Xiao Tan, Yue Li, Yan Li, Guy Mutangala Muloye, Lining Zhang, Xiaoyan Wang, Zengtao Wei View Abstract ❯

Inhibition of the PI3K/Akt signaling pathway reverses sorafenib‑derived chemo‑resistance in hepatocellular carcinoma Hao Zhang, Qingqing Wang, Jun Liu, Haoqiang Cao View Abstract ❯

Clinical significance of heat shock proteins in gastric cancer following hyperthermia stress: Indications for hyperthermic intraperitoneal chemoperfusion therapy Yinuo Tu, Yunhong Tian, Yinbing Wu, Shuzhong Cui View Abstract ❯

Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines Jun Li View Abstract ❯

Predictive value of gene methylation for second recurrence following surgical treatment of first bladder recurrence of a primary upper‑tract urothelial carcinoma Bao Guan, Yunchao Xing, Gengyan Xiong, Zhenpeng Cao, Dong Fang, Yifan Li, Yonghao Zhan, Ding Peng, Libo Liu, Xuesong Li, Liqun Zhou View Abstract ❯

Hematopoietic lineage cell‑specific protein 1 immunoreactivity indicates an increased risk of poor overall survival in patients with ovarian carcinoma Wenting Liu, Hiroaki Kajiyama, Kiyosumi Shibata, Yoshihiro Koya, Takeshi Senga, Fumitaka Kikkawa View Abstract ❯

Screening for susceptibility genes in hereditary non‑polyposis colorectal cancer Li Yu, Bo Yin, Kaiying Qu, Jingjing Li, Qiao Jin, Ling Liu, Chunlan Liu, Yuxing Zhu, Qi Wang, Xiaowei Peng, Jianda Zhou, Peiguo Cao, Ke Cao View Abstract ❯

Multicenter cross‑sectional screening of the BRCA gene for Chinese high hereditary risk breast cancer populations Hongyi Wei, Minghao Wang, Jianghua Ou, Weihua Jiang, Fuguo Tian, Yuan Sheng, Hengyu Li, Hong Xu, Ruishan Zhang, Aihua Guan, Changqing Wang, Hongchuan Jiang, Yu Ren, Jianjun He, Jian Liu, Weiwei Huang, Ning Liao, Xiangjun Cai, Jia Ming, Rui Ling, Yan Xu, Chunyan Hu, Jianguo Zhang, Baoliang Guo, Lizhi Ouyang, Ping Shuai, Zhenzhen Liu, Ling Zhong, Ruilin Jing, Zhen Zeng, Meng Zhang, Ting Zhang, Zhaoling Xuan, Xuanni Tan, Junbin Liang, Qinwen Pan, Li Chen, Fan Zhang, Linjun Fan, Yi Zhang, Xinhua Yang, Jingbo Li, Chongjian Chen, Jun Jiang View Abstract ❯

Enhancer of zeste homolog 2 blockade by RNA interference is implicated with inhibited proliferation, invasion and promoted apoptosis in endometrial carcinoma Juan Wang, Zhihong Ai, Jing Chen, Yincheng Teng, Jieping Zhu View Abstract ❯

Prostate cancer cell proliferation is suppressed by microRNA‑3160‑5p via targeting of F‑box and WD repeat domain containing 8 Ping Lin, Lijuan Zhu, Wenjing Sun, Zhengkai Yang, Hui Sun, Dong Li, Rongjun Cui, Xiulan Zheng, Xiaoguang Yu View Abstract ❯

Expression of metastasis‑associated lung adenocarcinoma transcript 1 long non‑coding RNA in vitro and in patients with non‑small cell lung cancer Ling Lin, Haiyan Li, Yefei Zhu, Susu He, Hongfei Ge View Abstract ❯

Potent antitumor effect of combination therapy with sub‑optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma Shiori Kinoshita, Masaki Ri, Takashi Kanamori, Sho Aoki, Takashi Yoshida, Tomoko Narita, Haruhito Totani, Asahi Ito, Shigeru Kusumoto, Takashi Ishida, Hirokazu Komatsu, Shinsuke Iida View Abstract ❯

Oldhamianoside II inhibits prostate cancer progression via regulation of EMT and the Wnt/β‑catenin signaling pathway Kaizhi Li, Xuemei Zhan, Jingyong Sun, Tianfeng Wang, Hongyan Dong, Fanbo Jing, Dongmei Li, Yu Cao, Yali Liu, Lin Wang, Shengnan Li View Abstract ❯

Expression levels of long non‑coding RNA HOXA distal transcript antisense RNA and metabotropic glutamate receptor 1 in pancreatic carcinoma, and their prognostic values Xiaoqing Wang, Lili Xiao, Haitao Yu View Abstract ❯

MIIP gene expression is associated with radiosensitivity in human nasopharyngeal carcinoma cells Hong‑Ping Zhou, Lu‑Xi Qian, Nan Zhang, Jia‑Jia Gu, Kai Ding, Jing Wu, Zhi‑Wei Lu, Ming‑Yu Du, Hong‑Ming Zhu, Jian‑Zhong Wu, Xia He, Li Yin View Abstract ❯

Euchromatic histone lysine methyltransferase 1 regulates cancer development in human gastric cancer by regulating E‑cadherin Yao Yang, Jianfeng Shen, Dongyi Yan, Biao Yuan, Shun Zhang, Jing Wei, Tao Du View Abstract ❯

Regulatory interactions between long noncoding RNA LINC00968 and miR‑9‑3p in non‑small cell lung cancer: A bioinformatic analysis based on miRNA microarray, GEO and TCGA Dong‑Yao Li, Wen‑Jie Chen, Jun Shang, Gang Chen, Shi‑Kang Li View Abstract ❯

Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma Chao Ma, Ji‑Zhi Zhao, Run‑Tai Lin, Lian Zhou, Yong‑Ning Chen, Li‑Jiang Yu, Tian‑Yin Shi, Mu Wang, Man‑Man Liu, Yao‑Ran Liu, Tao Zhang View Abstract ❯

Circulating and tumor‑infiltrating myeloid‑derived suppressor cells in cervical carcinoma patients Liangliang Wu, Hongyu Liu, Hongchuan Guo, Qiong Wu, Songyan Yu, Yuanyuan Qin, Gang Wang, Qiyan Wu, Rong Zhang, Lingxiong Wang, Lijun Zhang, Chunxi Liu, Shunchang Jiao, Tianyi Liu View Abstract ❯

Evaluation of efficacy and safety of minimally invasive segmentectomy in the treatment of lung cancer Changqing Shao, Cuiling Zheng, Wanshu Yan, Yi Shen, Zhixue Zhang View Abstract ❯

Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis Xuefeng Li, Longyun Li, Feng Liang, Guifeng Liu, Guoqing Zhao View Abstract ❯

Terminally differentiated CD8+ T cells and CD57‑FOXP3+CD8+ T cells are highly associated with the efficacy of immunotherapy using activated autologous lymphocytes Junji Akagi, Hideo Baba, Teruaki Sekine, Kenji Ogawa View Abstract ❯

Dioscin suppresses the viability of ovarian cancer cells by regulating the VEGFR2 and PI3K/AKT/MAPK signaling pathways Xianqing Guo, Xiao Ding View Abstract ❯

Long non‑coding RNA BRAF‑regulated lncRNA 1 promotes lymph node invasion, metastasis and proliferation, and predicts poor prognosis in breast cancer Jing Jiang, Sheng‑Hong Shi, Xu‑Jun Li, Long Sun, Qi‑Dong Ge, Chao Li, Wei Zhang View Abstract ❯

Tudor‑staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor‑κB and microRNA‑127 in human glioma U87MG cells Yongqiang Zhang, Jun Jia, Ying Li, Yan‑Ge Chen, Huan Huang, Yang Qiao, Yu Zhu View Abstract ❯

Inhibition of growth hormone receptor by Somavert reduces expression of GPER and prevents growth stimulation of triple‑negative breast cancer by 17β‑estradiol Rainer Girgert, Günter Emons, Carsten Gründker View Abstract ❯

The mechanism of miR-143 inducing apoptosis of liver carcinoma cells through regulation of the NF-κB pathway Yi Zheng, Fan Yang, Ling Fu, Kang Liu View Abstract ❯

Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity Shouyong Li, Yanlei Wei View Abstract ❯

Enhanced anti‑melanoma efficacy of interferon α‑2b via overexpression of ING4 by enhanced Fas/FasL‑mediated apoptosis Limin Cai, Jing Liu, Yu Wang, Hongxiao Chen, Yanli Ma, Yanhua Wang, Yongchen Wang View Abstract ❯

Exosome‑encapsulated microRNA‑223‑3p as a minimally invasive biomarker for the early detection of invasive breast cancer Mio Yoshikawa, Hisae Iinuma, Yasuko Umemoto, Takako Yanagisawa, Akiko Matsumoto, Hiromitsu Jinno View Abstract ❯

[Corrigendum] Clinical and biological effects of tumor associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Weiwei Zhang, Kejun Liu, Bin Ye, Guolin Hu, Kelei Zhao, Yazhou Ren, Weijiang Liang View Abstract ❯

Toll‑like receptor 4 and its associated proteins as prognostic factors for HCC treated by post‑radiotherapy surgery Zhi‑Feng Wu, Ying Wang, Ping Yang, Jia‑Zhou Hou, Jian‑Ying Zhang, Yong Hu, Zhao‑Chong Zeng View Abstract ❯

Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Xiaolan Shi, Wenfeng Wei, Ning Wang View Abstract ❯

Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods Lu Zhang, Cuihua Feng, Yamin Zhou, Qiong Zhou View Abstract ❯

Screening therapeutic targets of ribavirin in hepatocellular carcinoma Chen Xu, Liyun Luo, Yongjun Yu, Zhao Zhang, Yi Zhang, Haimei Li, Yue Cheng, Hai Qin, Xipeng Zhang, Hongmei Ma, Yuwei Li View Abstract ❯

Single‑cell whole‑genome sequencing identifies human papillomavirus integration in cervical tumour cells prior to and following radiotherapy Dong Yang, Weiyuan Zhang, Yang Liu, Junqing Liang, Tongqing Zhang, Yunbo Bai, Wenjing Hao, Kexin Ma, Danni Lu, Jing Chen View Abstract ❯

Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF‑κB pathway in vitro Sen Lu, Caizhao Lin, Xiaobin Cheng, Hanju Hua, Tao Xiang, Yu Huang, Xi Huang View Abstract ❯

Activation of the TLR4/MyD88 signaling pathway contributes to the development of human hepatocellular carcinoma via upregulation of IL‑23 and IL‑17A Yuming Kang, Guoai Su, Jianmin Sun, Yanli Zhang View Abstract ❯

PI3K/AKT inhibition induces compensatory activation of the MET/STAT3 pathway in non‑small cell lung cancer Chunan Bian, Zonghang Liu, Dakou Li, Lifeng Zhen View Abstract ❯

Quercetin induced apoptosis of human oral cancer SAS cells through mitochondria and endoplasmic reticulum mediated signaling pathways Yi‑Shih Ma, Chien‑Ning Yao, Hsin‑Chung Liu, Fu‑Shun Yu, Jen‑Jyh Lin, Kung‑Wen Lu, Ching‑Lung Liao, Fu‑Shin Chueh, Jing‑Gung Chung View Abstract ❯

Sesquiterpene lactone 6‑O‑angeloylplenolin reverses vincristine resistance by inhibiting YB‑1 nuclear translocation in colon carcinoma cells Changlong Li, Hezhen Wu, Yanfang Yang, Jianwen Liu, Zhenwen Chen View Abstract ❯

SB431542 inhibited cigarette smoke extract induced invasiveness of A549 cells via the TGF‑β1/Smad2/MMP3 pathway Ke Liao, Chen‑Wei Yong, Ke Hua View Abstract ❯

Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway See‑Hyoung Park, Jongsung Lee, Mi‑Ae Kang, Kyu Yun Jang, Jung Ryul Kim View Abstract ❯

Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1 Bing Xiao, Yanghua Fan, Minhua Ye, Shigang Lv, Bin Xu, Yi Chai, Miaojin Wu, Xingen Zhu View Abstract ❯

Overexpression of hsa‑miR‑125a‑5p enhances proliferation, migration and invasion of head and neck squamous cell carcinoma cell lines by upregulating C‑C chemokine receptor type 7 Shan Jin, Min‑Da Liu, Hong Wu, Pai Pang, Song Wang, Zhen‑Ning Li, Chang‑Fu Sun, Fa‑Yu Liu View Abstract ❯

Hiwi overexpression does not affect proliferation, migration or apoptosis of liver cancer cells in vitro or in vivo Hao Li, Chen‑Xi Shi, Hui Liu, Hai‑Han Zhang, Huai‑Ming Sang, Muhammad‑Djaleel Soyfoo, Jiu‑Liang Cao, Shun‑Fu Xu, Jian‑Xia Jiang View Abstract ❯

Activation of the SphK1/ERK/p‑ERK pathway promotes autophagy in colon cancer cells Chunyan Xu, Wenlu Zhang, Shiquan Liu, Wenhong Wu, Mengbin Qin, Jiean Huang View Abstract ❯

Evaluation of latent membrane protein 1 and microRNA‑155 for the prognostic prediction of diffuse large B cell lymphoma Xue Wu, Fei Wang, Yuan Li, Xiyong Wang, Ping Liu, Haijun Zhang, Zheng Ge, Xiaoping Zhang, Chong Gao, Baoan Chen View Abstract ❯

Multi‑modality imaging features distinguish pancreatic carcinoma from mass‑forming chronic pancreatitis of the pancreatic head Zhibing Ruan, Jun Jiao, Dingyu Min, Jinhuan Qu, Jing Li, Jing Chen, Qi Li, Chunhong Wang View Abstract ❯

Acute pro‑B‑Cell lymphoblastic leukemia transformed from myelodysplastic syndrome with an ASXL1 missense mutation: A case report with literature review Zhi‑Ping Guo, Yan‑Hong Tan, Jian‑Lan Li, Zhi‑Fang Xu, Xiu‑Hua Chen, Lian‑Rong Xu View Abstract ❯

KDM3A is not associated with metastasis and prognosis of breast cancer Juan Yao, Shutao Zheng, Baiyan Li, Xinxin Li, Wenya Liu View Abstract ❯

Increased expression of G9A contributes to carcinogenesis and indicates poor prognosis in hepatocellular carcinoma Jian Qin, Qingyun Li, Zhi Zeng, Ping Wu, Yanping Jiang, Tao Luo, Xiang Ji, Qiuping Zhang, Yarong Hao, Lang Chen View Abstract ❯

Gastrointestinal metastasis of primary lung cancer: An analysis of 366 cases Yue Hu, Noah Feit, Yanqin Huang, Wenhong Xu, Shu Zheng, Xiuzhen Li View Abstract ❯

MicroRNA‑28‑5p inhibits the migration and invasion of gastric cancer cells by suppressing AKT phosphorylation Fangtao Xiao, Zhenguo Cheng, Pengliang Wang, Baoheng Gong, Hanwei Huang, Yanan Xing, Funan Liu View Abstract ❯

KIT, NRAS, BRAF and FMNL2 mutations in oral mucosal melanoma and a systematic review of the literature Feng Chen, Qian Zhang, Yanjin Wang, Siwen Wang, Shawein Feng, Liyuan Qi, Xuefen Li, Chong Ding View Abstract ❯

Identification of proteins associated with paclitaxel resistance of epithelial ovarian cancer using iTRAQ‑based proteomics Yuanjing Wang, Hongxia Li View Abstract ❯

Gene expression signature for detection of gastric cancer in peripheral blood Jianing Shi, Changming Cheng, Jun Ma, Choong‑Chin Liew, Xiaoping Geng View Abstract ❯

Exosome‑mediated gefitinib resistance in lung cancer HCC827 cells via delivery of miR‑21 Changwen Jing, Haixia Cao, Xiaobing Qin, Shaorong Yu, Jianzhong Wu, Zhuo Wang, Rong Ma, Jifeng Feng View Abstract ❯

Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer Min‑Hsi Lin, You‑Zuo Chen, Mei‑Yu Lee, Ken‑Pen Weng, Hong‑Tai Chang, Shou‑Yu Yu, Bo‑Jhu Dong, Fan‑Rong Kuo, Li‑Tzu Hung, Li‑Feng Liu, Wei‑Shone Chen, Kuo‑Wang Tsai View Abstract ❯

Expression of DNA doublestrand repair proteins in oral leukoplakia and the risk of malignant transformation Minwen Zhu, Wei Liu, Linjun Shi, Xuan Xiao, Wenyan Wu, Lan Wu, Zengtong Zhou View Abstract ❯

Annexin A7 expression is downregulated in late‑stage gastric cancer and is negatively correlated with the differentiation grade and apoptosis rate Weihua Ye, Yong Li, Liqiao Fan, Qun Zhao, Hufang Yuan, Bibo Tan, Zhidong Zhang View Abstract ❯

Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways Lin Li, Rong‑Li Qiu, Yu Lin, Ying Cai, Yong Bian, Yan Fan, Xiao‑Jun Gao View Abstract ❯

Increased tumor vascularization is associated with the amount of immune competent PD‑1 positive cells in testicular germ cell tumors Lukas Jennewein, Georg Bartsch, Kilian Gust, Hans‑Michael Kvasnicka, Axel Haferkamp, Roman Blaheta, Michel Mittelbronn, Patrick N. Harter, Jens Mani View Abstract ❯

Suppression of GRP78 sensitizes human colorectal cancer cells to oxaliplatin by downregulation of CD24 Jingle Xi, Yufan Chen, Shangbin Huang, Fei Cui, Xinying Wang View Abstract ❯

Silibinin induces G1 arrest, apoptosis and JNK/SAPK upregulation in SW1990 human pancreatic cancer cells Xiaokai Zhang, Jiming Liu, Peng Zhang, Liting Dai, Zhihui Wu, Li Wang, Mingrong Cao, Jianwei Jiang View Abstract ❯

Effects of valproic acid on the susceptibility of human glioma stem cells for TMZ and ACNU Zhiying Li, Yun Xia, Xingyao Bu, Dongyi Yang, Yiqiang Yuan, Xiaohe Guo, Gangzhong Zhang, Zhanwei Wang, Jichao Jiao View Abstract ❯

Expression of miR‑146a‑5p in breast cancer and its role in proliferation of breast cancer cells Wei Gao, Jing Hua, Zhaoyang Jia, Jiping Ding, Zengwei Han, Yun Dong, Qing Lin, Yuan Yao View Abstract ❯

Overexpression of p62 is associated with poor prognosis and aggressive phenotypes in osteosarcoma Yao Lu, Qian Wang, Yong Zhou, Liang Sun, Bin Hu, Hanzhong Xue, Ming Li, Kun Zhang, Cheng Ren, Ning Duan, Hongliang Liu, Congming Zhang, Zhong Li, Teng Ma View Abstract ❯

Expression of serum Hsa-miR-93 in uterine cancer and its clinical significance Shengquan Fang, Min Gao, Shilu Xiong, Qian Chen, Huifeng Zhang View Abstract ❯

Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report Nobuyuki Maruyama, Kazuhide Nishihara, Toshiyuki Nakasone, Masanao Saio, Tessho Maruyama, Iori Tedokon, Tetsuya Ohira, Fumikazu Nimura, Akira Matayoshi, Ken‑Nosuke Karube, Naoki Yoshimi, Akira Arasaki View Abstract ❯

Identification of endothelial selectin as a potential prognostic marker in breast cancer Wei Zhang, Zhichao Zuo, Xiangyang Huang, Junjie Liu, Guanqiao Jin, Danke Su View Abstract ❯

53BP1 inhibits the migration and regulates the chemotherapy resistance of ovarian cancer cells Shuhui Hong, Xiaoyan Li, Ying Zhao, Qifeng Yang, Beihua Kong View Abstract ❯

Expression of UCP2 is associated with sensitivity to platinum‑based chemotherapy for ovarian serous carcinoma Masaru Kawanishi, Takeshi Fukuda, Masahiro Shimomura, Yuta Inoue, Takuma Wada, Reiko Tasaka, Tomoyo Yasui, Toshiyuki Sumi View Abstract ❯

S100A16 up‑regulates Oct4 and Nanog expression in cancer stem‑like cells of Yumoto human cervical carcinoma cells Nariaki Tomiyama, Ryuji Ikeda, Yukihiko Nishizawa, Shogo Masuda, Yusuke Tajitsu, Yasuo Takeda View Abstract ❯

MELK as a potential target to control cell proliferation in triple‑negative breast cancer MDA‑MB‑231 cells Gang Li, Mei Yang, Li Zuo, Mei‑Xing Wang View Abstract ❯

Quantitative proteomic analysis of the miR‑148a‑associated mechanisms of metastasis in non‑small cell lung cancer Dandan Chu, Jing Li, Hechun Lin, Xiao Zhang, Hongyu Pan, Lei Liu, Tao Yu, Mingxia Yan, Ming Yao View Abstract ❯

Role of hepcidin and iron metabolism in the onset of prostate cancer Bin Zhao, Ruiqian Li, Gang Cheng, Zhiyao Li, Zhiping Zhang, Jun Li, Guoying Zhang, Chengwei Bi, Chen Hu, Libo Yang, Yonghong Lei, Qilin Wang View Abstract ❯

Differences between epithelial and mesenchymal human tongue cancer cell lines in experimental metastasis Wei‑Xin Cai, Ru Qing Yu, Li Ma, Hong Zhang Huang, Li Wu Zheng, Roger Zwahlen View Abstract ❯

Gene microarray analysis of the circular RNAs expression profile in human gastric cancer Yonghua Shen, Juanjuan Zhang, Ziyi Fu, Bin Zhang, Min Chen, Xiufeng Ling, Xiaoping Zou View Abstract ❯

Loss of opioid binding protein/cell adhesion molecule‑like gene expression in gastric cancer Ning Zhang, Jide Xu, Yuhong Wang, Xuhua Heng, Liteng Yang, Xiangbin Xing View Abstract ❯

Mps1 is associated with the BRAFV600E mutation but does not rely on the classic RAS/RAF/MEK/ERK signaling pathway in thyroid carcinoma Yike Li, Yanyan Zhang, Shuaishuai Xiao, Pengzhou Kong, Caixia Cheng, Ruyi Shi, Fang Wang, Ling Zhang, Juan Wang, Zhiwu Jia, Shuai Wu, Yun Liu, Jiansheng Guo, Xiaolong Cheng, Yongping Cui, Jing Liu View Abstract ❯

Retinoic acid‑metabolizing enzyme cytochrome P450 26A1 promotes skin carcinogenesis induced by 7,12‑dimethylbenz[a]anthracene Makoto Osanai, Akira Takasawa, Kumi Takasawa, Masaki Murata, Norimasa Sawada View Abstract ❯

Systematic prediction of target genes and pathways in cervical cancer from microRNA expression data Rui Chen, Yong‑Hua Shi, Hong Zhang, Jian‑Yun Hu, Yi Luo View Abstract ❯

Effects of microRNA‑20a on the proliferation, migration and apoptosis of multiple myeloma via the PTEN/PI3K/AKT signaling pathway Yanxia Jiang, Hong Chang, Guoan Chen View Abstract ❯

Clinical significance of androgen receptor expression in triple negative breast cancer‑an immunohistochemistry study Ya‑Xuan Liu, Ke‑Jing Zhang, Li‑Li Tang View Abstract ❯

Comparative analysis of the surgical treatment results for multiple myeloma bone disease of the spine and the long bone/soft tissue Jiangtao Shen, Xinru Du, Lingxiu Zhao, Hui Luo, Ziyu Xu View Abstract ❯

Effect of CXCR4 silencing with shRNA on MAPK signaling in ovarian cancer Xiuli Wang, Hongying Wang, Xia Wei, Aixia Wang, Lina Wen, Li Wang, Qun Huang View Abstract ❯

Estrogen receptor‑α36‑mediated rapid estrogen signaling regulates 78 kDa glucose‑regulated protein expression in gastric carcinoma cells Zhengqi Fu, Xuming Wang, Zhaoyi Wang, Lijiang Liu View Abstract ❯

Mesenchymal stem cells confer resistance to doxorubicin‑induced cardiac senescence by inhibiting microRNA‑34a Wenzheng Xia, Meng Hou View Abstract ❯

Long non‑coding RNA ZNF674‑1 acts as a cancer suppressor in nasopharyngeal carcinoma Guo‑Hui Nie, Zhao Li, Hong‑Fang Duan, Liang Luo, Hong‑Yi Hu, Xiao‑Fan Chen, Wei Zhang View Abstract ❯

Cytotoxic activity of Shp2 inhibitor fumosorinone in human cancer cells Chuan Chen, Tongdan Xue, Peng Fan, Linlin Meng, Jingjing Wei, Duqiang Luo View Abstract ❯

miR‑197 is downregulated in cervical carcinogenesis and suppresses cell proliferation and invasion through targeting forkhead box M1 Qiyan Hu, Ke Du, Xiaogang Mao, Siqing Ning View Abstract ❯

Solanine reverses multidrug resistance in human myelogenous leukemia K562/ADM cells by downregulating MRP1 expression Ying‑Jie Yi, Xiu‑Hong Jia, Cong Zhu, Jian‑Yong Wang, Jie‑Ru Chen, Hong Wang, You‑Jie Li View Abstract ❯

MicroRNA‑216b regulated proliferation and invasion of non‑small cell lung cancer by targeting SOX9 Sida Liu, Han Dong, Hui Dai, Danwei Liu, Zhihao Wang View Abstract ❯

Acriflavine enhances the antitumor activity of the chemotherapeutic drug 5‑fluorouracil in colorectal cancer cells Parisa Zargar, Esmaeel Ghani, Farideh Jalali Mashayekhi, Amin Ramezani, Ebrahim Eftekhar View Abstract ❯

Safety and feasibility of single‑port laparoscopic multivisceral resection for locally advanced left colon cancer Mitsuyoshi Tei, Masahisa Otsuka, Yozo Suzuki, Kentaro Kishi, Masahiro Tanemura, Hiroki Akamatsu View Abstract ❯

MicroRNA‑154 functions as a tumor suppressor in non‑small cell lung cancer through directly targeting B‑cell‑specific Moloney murine leukemia virus insertion site 1 Sida Liu, Yang Yang, Lu Chen, Danwei Liu, Han Dong View Abstract ❯

5-7 October, 2017, Metropolitan Hotel, Athens, Greece 22nd World Congress on Advances in Oncology & 20th International Symposium on Molecular Medicine 3-4 October 2017, Pre-Congress Workshop: 'Next-Generation Sequencing – Library construction and quality control'

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