IFC(EDITORIAL BOARD)

Publication date: June 2017
Source:DNA Repair, Volume 54





http://ift.tt/2q4PpZq

Submucosal neurons and enteric glial cells expressing the P2X7 receptor in rat experimental colitis

Publication date: Available online 11 May 2017
Source:Acta Histochemica
Author(s): Marcos Vinícius da Silva, Aline Rosa Marosti, Cristina Eusébio Mendes, Kelly Palombit, Patricia Castelucci
The aim of this study was to evaluate the effect of ulcerative colitis on the submucosal neurons and glial cells of the submucosal ganglia of rats. 2,4,6-Trinitrobenzene sulfonic acid (TNBS; colitis group) was administered in the colon to induce ulcerative colitis, and distal colons were collected after 24h. The colitis rats were compared with those in the sham and control groups. Double labelling of the P2X7 receptor with calbindin (marker for intrinsic primary afferent neurons, IPANs, submucosal plexus), calretinin (marker for secretory and vasodilator neurons of the submucosal plexus), HuC/D and S100β was performed in the submucosal plexus. The density (neurons per area) of submucosal neurons positive for the P2X7 receptor, calbindin, calretinin and HuC/D decreased by 21%, 34%, 8.2% and 28%, respectively, in the treated group. In addition, the density of enteric glial cells in the submucosal plexus decreased by 33%. The profile areas of calbindin-immunoreactive neurons decreased by 25%. Histological analysis revealed increased lamina propria and decreased collagen in the colitis group. This study demonstrated that ulcerative colitis affected secretory and vasodilatory neurons, IPANs and enteric glia of the submucosal plexus expressing the P2X7 receptor.



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Chemicogenetic Restoration of the Prefrontal Cortex to Amygdala Pathway Ameliorates Stress-Induced Deficits

<span class="paragraphSection"><div class="boxTitle">Abstract</div>Corticosteroid stress hormones exert a profound impact on cognitive and emotional processes. Understanding the neuronal circuits that are altered by chronic stress is important for counteracting the detrimental effects of stress in a brain region- and cell type-specific manner. Using the chemogenetic tool, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), which enables the remote, noninvasive and long-lasting modulation of cellular activity and signal transduction in discrete neuronal populations in vivo, we sought to identify the specific pathways that play an essential role in stress responses. We found that prolonged severe stress induced the diminished glutamatergic projection from pyramidal neurons in prefrontal cortex (PFC) to GABAergic interneurons in basolateral amygdala (BLA), leading to the loss of feedforward inhibition and ensuing hyperexcitability of BLA principal neurons, which caused a variety of behavioral abnormalities. Activating PFC pyramidal neurons with hM3D(Gq) DREADD restored the functional connection between PFC and BLA in stressed animals, resulting in the rescue of recognition memory, normalization of locomotor activity and reduction of aggressive behaviors. Inhibiting BLA principal neurons directly with hM4D(Gi) DREADD also blocked BLA hyperactivity and aggressive behaviors in stressed animals. These results have offered an effective avenue to counteract the stress-induced disruption of circuitry homeostasis.</span>

http://ift.tt/2pzJ0Bl

Global Tactile Coding in Rat Barrel Cortex in the Absence of Local Cues

<span class="paragraphSection"><div class="boxTitle">Abstract</div>Although whisker-related perception is based predominantly on local, near-instantaneous coding, global, intensive coding, which integrates the vibrotactile signal over time, has also been shown to play a role given appropriate behavioral conditions. Here, we study global coding in isolation by studying head-fixed rats that identified pulsatile stimuli differing in pulse frequency but not in pulse waveforms, thus abolishing perception based on local coding. We quantified time locking and spike counts as likely variables underpinning the 2 coding schemes. Both neurometric variables contained substantial stimulus information, carried even by spikes of single barrel cortex neurons. To elucidate which type of information is actually used by the rats, we systematically compared psychometric with neurometric sensitivity based on the 2 coding schemes. Neurometric performance was calculated by using a population-encoding model incorporating the properties of our recorded neuron sample. We found that sensitivity calculated from spike counts sampled over long periods (>1 s) matched the performance of rats better than the one carried by spikes time-locked to the stimulus. We conclude that spike counts are more relevant to tactile perception when instantaneous kinematic parameters are not available.</span>

http://ift.tt/2pzH3VJ

From CNTNAP2 to Early Expressive Language in Infancy: The Mediation Role of Rapid Auditory Processing

<span class="paragraphSection"><div class="boxTitle">Abstract</div>Although it is clear that early language acquisition can be a target of <span style="font-style:italic;">CNTNAP2</span>, the pathway between gene and language is still largely unknown. This research focused on the mediation role of rapid auditory processing (RAP). We tested RAP at 6 months of age by the use of event-related potentials, as a mediator between common variants of the <span style="font-style:italic;">CNTNAP2</span> gene (rs7794745 and rs2710102) and 20-month-old language outcome in a prospective longitudinal study of 96 Italian infants. The mediation model examines the hypothesis that language outcome is explained by a sequence of effects involving RAP and <span style="font-style:italic;">CNTNAP2</span>. The ability to discriminate spectrotemporally complex auditory frequency changes at 6 months of age mediates the contribution of rs2710102 to expressive vocabulary at 20 months. The indirect effect revealed that rs2710102 C/C was associated with lower P3 amplitude in the right hemisphere, which, in turn, predicted poorer expressive vocabulary at 20 months of age. These findings add to a growing body of literature implicating RAP as a viable marker in genetic studies of language development. The results demonstrate a potential developmental cascade of effects, whereby <span style="font-style:italic;">CNTNAP2</span> drives RAP functioning that, in turn, contributes to early expressive outcome.</span>

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Superior Neuronal Detection of Snakes and Conspecific Faces in the Macaque Medial Prefrontal Cortex

<span class="paragraphSection"><div class="boxTitle">Abstract</div>Snakes and conspecific faces are quickly and efficiently detected in primates. Because the medial prefrontal cortex (mPFC) has been implicated in attentional allocation to biologically relevant stimuli, we hypothesized that it might also be highly responsive to snakes and conspecific faces. In this study, neuronal responses in the monkey mPFC were recorded, while monkeys discriminated 8 categories of visual stimuli. Here, we show that the monkey mPFC neuronal responses to snakes and conspecific faces were unique. First, the ratios of the neurons that responded strongly to snakes and monkey faces were greater than those of the neurons that responded strongly to the other stimuli. Second, mPFC neurons responded stronger and faster to snakes and monkey faces than the other categories of stimuli. Third, neuronal responses to snakes were unaffected by low-pass filtering of the images. Finally, activity patterns of responsive mPFC neurons discriminated snakes from the other stimuli in the second 50 ms period and monkey faces in the third period after stimulus onset. These response features indicate that the mPFC processes fast and coarse visual information of snakes and monkey faces, and support the hypothesis that snakes and social environments have shaped the primate visual system over evolutionary time.</span>

http://ift.tt/2qVFXYU

Spatial Asymmetry and Short-Term Suppression Underlie Direction Selectivity of Synaptic Excitation in the Mouse Visual Cortex

<span class="paragraphSection"><div class="boxTitle">Abstract</div>Direction selectivity (DS) of neuronal responses is fundamental for motion detection. With in vivo whole-cell voltage-clamp recordings from layer (L)4 neurons in the mouse visual cortex, we observed a strong correlation between DS and spatial asymmetry in the distribution of excitatory input strengths. This raises an interesting possibility that the latter may contribute to DS. The preferred direction of excitatory input was found from the stronger to weaker side of its spatial receptive field. A simple linear summation of asymmetrically distributed excitatory responses to stationary flash stimuli however failed to predict the correct directionality: it at best resulted in weak DS with preferred direction opposite to what was observed experimentally. Further studies with sequential 2 flash-bar stimulation revealed a short-term suppression of excitatory input evoked by the late bar. More importantly, the level of the suppression positively correlated with the relative amplitude of the early-bar response. Implementing this amplitude-dependent suppressive interaction can successfully predict DS of excitatory input. Our results suggest that via nonlinear temporal interactions, the spatial asymmetry can be transformed into differential temporal integration of inputs under opposite directional movements. This mechanism may contribute to the DS of excitatory inputs to L4 neurons.</span>

http://ift.tt/2pzAOkH

Review of Software for Decision Modelling [Internet].

The aim of this review was to inform the update of the NICE Technology Appraisal software requirements for economic model submissions.

http://ift.tt/2q7HsAw

Process Manual for the Endorsement of Guidance and Quality Standard Support Resources [Internet].

The National Institute for Health and Care Excellence (NICE) is the independent body responsible for driving improvement and excellence in the health and social care system. We develop guidance, standards and information on high-quality health and social care. We also advise on ways to promote healthy living and prevent ill health.

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Unmet need for postpartum family planning in Alexandria, Egypt

Publication date: Available online 8 May 2017
Source:Alexandria Journal of Medicine
Author(s): Heba Mahmoud Taha Elweshahi, Gihan Ismail Gewaifel, Sameh Saad EL-Din Sadek, Omnia Galal El-Sharkawy
BackgroundPostpartum women are a priority group to target on trying to solve the problem of closely spaced pregnancies as well as population explosion.AimTo estimate the level of unmet need for postpartum family planning one year after birth as well as identify factors associated with having unmet need in Alexandria, Egypt.MethodsA cross sectional survey was adopted. A sample of 1500 women one year post-partum was selected. A predesigned interviewing questionnaire was used to collect data. Data include their socio-demographic characteristics and current use of family planning method. Those with unmet need for postpartum family planning (PPFP) were asked about the reasons for non-use, their intention to use in the future and their knowledge about contraceptives.SettingPublic settings delivering routine immunization for infants in Alexandria.ResultsOut of 1500 postpartum women, 1370 (91.33%) have a real demand for family planning. Out of those with a real demand for family planning (n=1370), 1106 (80.72%) were using a modern contraceptive method and only 41 (3%) were using a traditional method for birth control while the remaining 223 (16.28%) were having unmet need for postpartum family planning. Amenorrhea, breast feeding, fear of side effects, discontinuation due to health concerns and pressure from the surroundings were the most common cited reasons for non-use.ConclusionIntegration of family planning education during antenatal, natal and postnatal care services in Egypt should be actively initiated. Women with unmet need for PPFP in general and those with intention to use a contraceptive in particular should be targeted for recruitment efforts and services in any program tackle the problem of family planning and rising fertility in Egypt.



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Evaluation of sensitivity and specificity of bone marrow trephine biopsy tests in an Indian teaching hospital

Publication date: Available online 5 May 2017
Source:Alexandria Journal of Medicine
Author(s): Sima Chauhan, Sarita Pradhan, Ripunjaya Mohanty, Abhishek Saini, Kumudini Devi, Mahesh Chandra Sahu
IntroductionBone marrow aspiration (BMA) and bone marrow biopsy (BMB) is an indispensable diagnostic tool for evaluating haematological and non-haematological disorders and patient follow-up in present era. We have compared the advantages of trephine biopsy over bone marrow aspiration in these patients.Aim and objectiveTo evaluate sensitivity and specificity of trephine biopsy test for haematological and non haematological disorder patients in comparison to bone marrow aspiration test.Materials and methodIn this 1year prospective study (June 2014–May 2015), we evaluated the haematological and non-haematological disorder patients by BMA and BMB (aided with I.H.C. when ever needed). The sensitivity and specificity of the tests were calculated.ResultsAmong, final 504 hemotological/non haematological disorder patients, 416 cases were diagnosed (+ve) in BMA test, where as it was 494 in BMB test and with chi² test it was highly significant as p=0.0001. It was concluded that True positive cases were 416, True negative were 9 cases, false negative 78 cases and false positive was in one case only. The sensitivity and specificity of bone marrow trephine biopsy test was 84% and 90% respectively.ConclusionBMB (aided with I.H.C) is a gold standard test for detecting different haematological and non hamatological disorders. In our study the sensitivity and specificity of BMB test was 84% and 90% respectively. When performed in association with BMA in the same sitting, significantly augments the chances of reaching a correct diagnosis.



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The effects of valproic acid on the mRNA expression of Natriuretic Peptide Receptor A and KQT-like subfamily Q-1 in human colon cancer cell lines

Publication date: Available online 28 April 2017
Source:Alexandria Journal of Medicine
Author(s): Mona Hajikazemi, Hoda Sohrabi, Ahad Yamchi, Mohsen Saeedi
Aim and objectivesThe histone deacetylase (HDAC) inhibitor, Valproic Acid (VPA), causes growth inhibition and apoptosis in colorectal cancer cells. HDAC inhibition is associated with the transcriptional regulation of Natriuretic Peptide Receptor-A (NPR-A). NPR-A regulates voltage-gated potassium channel, KQT-like subfamily Q, member 1 (KCNQ1). NPR-A and KCNQ1 are also involved in the initiation and propagation of cancer cells. In this study, we investigated the simultaneous expressional changes of NPR-A and KCNQ1 among VPA-treated colon cancer cells.Materials and methodsHuman colorectal cancer cells were cultured and treated with increasing concentrations of VPA at different time points. MTT viability test was conducted to evaluate the growth inhibition. Real Time RT-PCR was used to quantify differential mRNA expression of NPR-A and KCNQ1 genes. Two-way ANOVA and bonferroni post-tests were used to analyze data statistically.ResultsWe showed that VPA treatment inhibits the growth of SW-480 cells more efficiently compared to HT-29. NPR-A and KCNQ1 genes were significantly upregulated upon VPA treatment in both cell lines (P<0.0001).ConclusionThe alteration of NPR-A and KCNQ1 genes were more ordered among SW-480 cancer cells. The expressional changes of KCNQ1 and NPR-A among VPA treated human colon cancer cells follow the same pattern in similar combinations. VPA could regulate the expression of KCNQ1 through altering the mRNA expression of NPR-A.



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Assessing prescriber’s awareness of essential medicine list, hospital drug formulary and utilization of standard treatment guidelines in a tertiary healthcare facility in North-Central Nigeria

Publication date: Available online 26 April 2017
Source:Alexandria Journal of Medicine
Author(s): Abdullahi Hassan, Gobir Abdulrazaq Abdullahi, Abubakar Aisha Ahmed, Adamu Sabiu, Uwaya John, Gwamna Ezekeil, Yahaya Aliyu Ibrahim




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NICE DSU Technical Support Document 10: The Use of Mapping Methods to Estimate Health State Utility Values [Internet].

The NICE Guide to the Methods of Technology Appraisals recommends that quality adjusted life years (QALYs) are used as the measure of outcome for economic evaluation, and that the EQ-5D is the preferred measure of health-related utility to calculate QALYs. The guide also recognises that EQ-5D data may not always be available to analysts producing submissions and reports for NICE. Where such data are not available, the guide states that mapping can be used to predict EQ-5D data.

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NICE DSU Technical Support Document 11: Alternatives to EQ-5D for Generating Health State Utility Values [Internet].

The NICE Guide to the Methods of Technology Appraisal expresses a preference for using the EQ-5D for adult populations to estimate the Quality Adjusted Life Year (QALY) impact of different technologies. Alternative methods to generating health state utility values (HSUVs) will be considered by NICE in place of EQ-5D when EQ-5D data are either unavailable or inappropriate. Unavailability should be established from a systematic search of the literature. Even if EQ-5D data is unavailable, mapping can be used as an alternative to estimate EQ-5D values rather than the alternative methods described in this Technical Support Guide (see TSD 101). Claims that EQ-5D is inappropriate for measuring the Health Related Quality of Life (HRQL) for a patient group or a specific treatment must be supported by evidence.

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Key Therapeutic Topics – Medicines Management Options for Local Implementation: Interim Process Statement [Internet].

This interim process statement has been produced by the National Institute for Health and Clinical Excellence (NICE) to guide the development of the QIPP key therapeutics document, 'Key therapeutic topics – Medicines management options for local implementation'. It provides an overview of the key process and principles, and describes all stages of the development of the QIPP key therapeutics document. These procedures are designed to ensure that a robust, quality-assured document is developed for the NHS in an open, transparent and timely way, with appropriate input from key groups. This interim process statement uses the NICE Implementation Support Tool process as an overarching guide to the principles of its development.

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NICE DSU Technical Support Document 12: The Use of Health State Utility Values in Decision Models [Internet].

The National Institute for Health and Clinical Excellence (NICE) provides recommendations on health related quality of life (HRQoL) data used in submissions in their Guide to the Methods of Technology Appraisal. As different measures can produce different health state utility values (HSUV), the Institute state a preference for EQ-5D data to facilitate comparison across disease areas and interventions. However, inconsistencies in the methodologies used when applying HSUVs in economic models will produce discrepancies in results generated from decision analytic models, even when using the same measure, thus undermining policy decision making based on cost per quality adjusted life year (QALY) thresholds.

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The Value of Innovation [Internet].

The aim of this review is to provide an overview of how innovation is currently valued in the UK health system and the potential initiatives that can be adopted in order to promote innovation in the NHS. The report includes a review of the scientific, policy and economic literature.

http://ift.tt/2q7T1rH

Good Practice Guidance – Interim Process Statement [Internet].

This interim process statement has been produced to guide the development of good practice guidance. It provides an overview of the key process principles and describes all stages of the development of good practice guidance. These procedures are designed to ensure that a robust, quality-assured, resource is developed for the NHS in an open, transparent and timely way, with appropriate input from key groups.

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A Pilot Study of Value of Information Analysis to Support Research Recommendations for NICE [Internet].

This project developed as a result of the activities of the Research Teams at the Centre for Health Economics, University of York, and ScHARR at the University of Sheffield in the methods and application of decision analysis and value of information analysis as a means of informing the research recommendations made by NICE, as part of its Guidance to the NHS in England and Wales, and informing the deliberations of the NICE Research and Development Committee.

http://ift.tt/2r0bYML

Health Technologies Adoption Programme: Process Guide for Adoption Support Resources for Health Technologies [Internet].

NICE guidance on health technologies includes the use of new and existing medicines, treatments and procedures in the NHS; this includes medicines and use of medical devices and diagnostics. Putting NICE guidance into practice can be challenging, and this is why NICE provides support.

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Medicines Optimisation: Key Therapeutic Topics – Integrated Process Statement [Internet].

This integrated process statement relates to the document 'Medicines optimisation: key therapeutic topics' (hereafter referred to as key therapeutic topics). It has been produced to explain how key therapeutic topics are developed. It provides an overview of the key process and principles, and describes all stages of the development of key therapeutic topics. These procedures are designed to ensure that a robust, quality-assured document is developed in an open, transparent and timely way, with appropriate input from key groups. This process statement uses the NICE Implementation Support Tool process as an overarching guide to the principles of its development.

http://ift.tt/2q4O70B

NICE DSU Technical Support Document 9: The Identification, Review and Synthesis of Health State Utility Values from the Literature [Internet].

Health state utility values (HSUVs) are important parameters in decision models, and NICE requires evidence that HSUV estimates from the published literature have been identified and selected systematically. NICE provides a reference case analysis with specific requirements for how HSUVs are derived, including a preference for HSUV values derived from the EQ-5D. This Technical Support Document (TSD) discusses how to systematically identify and select HSUVs from the literature in order to meet the requirements of the NICE Methods Guide. In addition, the TSD provides guidance on quality and relevance assessment, data extraction, selection of values and synthesis. Two case studies are used throughout this document; a review of HSUVs in osteoporosis-related conditions and a review of HSUVs in breast cancer.

http://ift.tt/2r05a1H

Evidence Summaries: New Medicines – Interim Process Statement [Internet].

This interim process statement has been produced to guide the development of 'Evidence summaries: new medicines' (ESNMs). It provides an overview of the key process principles and describes all stages of the development of ESNMs. These procedures are designed to ensure that a robust, quality-assured, commentary is developed for the NHS in an open, transparent and timely way, with appropriate input from key groups.

http://ift.tt/2q4KHLb

NICE DSU Technical Support Document 8: An Introduction to the Measurement and Valuation of Health for NICE Submissions [Internet].

NICE requires consistency in its decision making and so has developed a reference case of methods for Technology Appraisal that includes the measurement and valuation of health.

http://ift.tt/2q7Ho3K

NICE DSU Technical Support Document 13: Identifying and Reviewing Evidence to Inform the Conceptualisation and Population of Cost-Effectiveness Models [Internet].

This Technical Support Document (TSD) is concerned with methods for identifying and reviewing evidence to inform models developed to estimate the cost-effectiveness of health technologies, in particular model parameter estimates, in the NICE Technology Appraisal Process. The NICE Guide to the Methods of Appraisal states that for parameters relating to treatment effects a full systematic review is required, and that the process of assembling evidence for all parameters needs to be systematic, transparent and justifiable. Evidence must be identified, quality assessed and, when appropriate, pooled using explicit criteria and justifiable and reproducible methods. The Methods Guide goes on to state that evidence will typically be drawn from a number of different sources. These sources might include cohort studies for parameters relating to the natural history of the condition, randomised controlled trials for relative treatment effects, and cross-sectional surveys for resource use and costs. Methodological standards for reviewing the broad range of relevant evidence in the context of model development do not currently exist. The processes through which evidence is identified and selected remain largely unreported with the result that the process of using evidence within models lacks transparency. Guidance is needed regarding approaches for reviewing of evidence to inform the model development process and for informing parameter values in cost-effectiveness models.

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Evidence Summaries: Unlicensed and Off-Label Medicines – Interim Process Statement [Internet].

This interim process statement has been produced to guide the development of 'Evidence summaries: unlicensed and off-label medicines' (ESUOMs). It provides an overview of the key process principles and describes all stages of development for ESUOMs. These procedures are designed to ensure that a robust, quality-assured, commentary is developed for the NHS in an open, transparent and timely way, with appropriate input from key groups.

http://ift.tt/2q4PX19

Ii

Publication date: 2016
Source:Australian Nurses' Dictionary





http://ift.tt/2qu8PIi

Chapter 31 Food Allergy and Intolerance

Publication date: 2018
Source:Integrative Medicine
Author(s): Alan R. Gaby




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Development and physicochemical characterization of acetalated dextran aerosol particle systems for deep lung delivery

Publication date: 15 June 2017
Source:International Journal of Pharmaceutics, Volume 525, Issue 1
Author(s): Zimeng Wang, Sweta K. Gupta, Samantha A. Meenach
Biocompatible, biodegradable polymers are commonly used as excipients to improve the drug delivery properties of aerosol formulations, in which acetalated dextran (Ac-Dex) exhibits promising potential as a polymer in various therapeutic applications. Despite this promise, there is no comprehensive study on the use of Ac-Dex as an excipient for dry powder aerosol formulations. In this study, we developed and characterized pulmonary drug delivery aerosol microparticle systems based on spray-dried Ac-Dex with capabilities of (1) delivering therapeutics to the deep lung, (2) targeting the particles to a desired location within the lungs, and (3) releasing the therapeutics in a controlled fashion. Two types of Ac-Dex, with either rapid or slow degradation rates, were synthesized. Nanocomposite microparticle (nCmP) and microparticle (MP) systems were successfully formulated using both kinds of Ac-Dex as excipients and curcumin as a model drug. The resulting MP were collapsed spheres approximately 1μm in diameter, while the nCmP were similar in size with wrinkled surfaces, and these systems dissociated into 200nm nanoparticles upon reconstitution in water. The drug release rates of the Ac-Dex particles were tuned by modifying the particle size and ratio of fast to slow degrading Ac-Dex. The pH of the environment was also a significant factor that influenced the drug release rate. All nCmP and MP systems exhibited desirable aerodynamic diameters that are suitable for deep lung delivery (e.g. below 5μm). Overall, the engineered Ac-Dex aerosol particle systems have the potential to provide targeted and effective delivery of therapeutics into the deep lung.

Graphical abstract

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Deep coverage of the beer proteome

Publication date: Available online 3 May 2017
Source:Journal of Proteomics
Author(s): Martina Grochalová, Hana Konečná, Karel Stejskal, David Potěšil, Danuše Fridrichová, Eva Srbová, Kateřina Ornerová, Zbyněk Zdráhal
We adopted an approach based on peptide immobilized pH gradient-isoelectric focusing (IPG-IEF) separation, coupled with LC-MS/MS, in order to maximize coverage of the beer proteome. A lager beer brewed using traditional Czech technology was degassed, desalted and digested. Tryptic peptides were separated by isoelectric focusing on an immobilized pH gradient strip and, after separation, the gel strip was divided into seven equally sized parts. Peptides extracted from gel fractions were analyzed by LC-MS/MS. This approach resulted in a three-fold increase in the number of proteins identified (over 1700) when compared to analysis of unfractionated beer processed by a filter-aided sample preparation (FASP). Over 1900 protein groups (PGs) in total were identified by both approaches.SignificanceThe study significantly extends knowledge about the beer proteome and demonstrates its complexity. Detailed knowledge of the protein content, especially gluten proteins, will enhance the evaluation of potential health risks related to beer consumption (coeliac disease) and will contribute to improving beer quality.

Graphical abstract

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11 The Respiratory System

Publication date: 2017
Source:Conn's Current Therapy 2017
Author(s): Edward T. Bope, Rick D. Kellerman




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Chapter 9 The rheumatological long case

Publication date: 2017
Source:Examination Medicine
Author(s): Nicholas J Talley, Simon O'Connor




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Chapter 16 Common short cases

Publication date: 2017
Source:Examination Medicine
Author(s): Nicholas J Talley, Simon O'Connor




http://ift.tt/2r48Kb6

Appendix VI Patient Teaching Guides

Publication date: 2017
Source:Ferri's Clinical Advisor 2017





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P

Publication date: 2017
Source:Ferri's Clinical Advisor 2017
Author(s): Fred F. Ferri




http://ift.tt/2r4agKw

L

Publication date: 2017
Source:Ferri's Clinical Advisor 2017
Author(s): Fred F. Ferri




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Part B Immunizations and Chemoprophylaxis

Publication date: 2017
Source:Ferri's Clinical Advisor 2017
Author(s): Fred F. Ferri




http://ift.tt/2qualK7

41 Genetic Disorders

Publication date: 2017
Source:Pediatric Primary Care
Author(s): Martha Driessnack, Sandra Daack-Hirsch




http://ift.tt/2qurmnw

5 Atopic Dermatitis, Eczema, and Noninfectious Immunodeficiency Disorders

Publication date: 2016
Source:Andrews' Diseases of the Skin





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27 Management of Chronic Venous Insufficiency

Publication date: 2016
Source:Cardiovascular Intervention
Author(s): Nicolas W. Shammas




http://ift.tt/2qul5Ix

Involution processes of follicular atresia and post-ovulatory complex in a characid fish ovary: a study of apoptosis and autophagy pathways

Abstract

Recent studies seem to indicate that apoptosis and autophagy can act cooperatively in fish ovaries in order to achieve more effective ovarian regression after spawning. Considering the importance of tissue remodeling in ovarian functioning, we sought to morphologically characterize the involution processes of follicular atresia and post-ovulatory complexes using Astyanax altiparanae as an experimental model, and to determine the location of proteins involved in apoptosis and autophagy throughout this process. Fifteen females were collected after reproductive management. Fragments of the left ovaries were removed, fixed, and prepared for light microscopy and immunofluorescence analyses. The main characteristics of the involution processes were found to be consistent with previous descriptions. However, there were certain morphological peculiarities that do not appear to have been described for any other species thus far. These peculiarities may be related to the focus of this study on a single species, which allows for a more detailed investigation into morphological changes than studies on multiple species. Autophagy was also found to precede apoptosis in both involution processes in A. altiparanae. This may be related to the energy recycling process required before the removal of degenerated follicular cells by apoptosis. Thus, these results support the idea that there is crosstalk between autophagy and apoptosis pathways in ovarian involution processes, as well as the idea that the cell death pathways of these processes are conserved between teleost species with external fertilization.

http://ift.tt/2qu47Kg

Correlation between three-dimensional power Doppler and morphometric measurement of endometrial vascularity at the time of embryo implantation in women with unexplained recurrent miscarriage

Abstract

Power Doppler in combination with three-dimensional (3D-PD) ultrasonography has been used as a noninvasive tool to evaluate the vascularity. However, it is unclear whether 3D-PD can accurately reflect endometrial vascularization and replace the invasive endometrial biopsy. This study aims to investigate the correlation between 3D-PD and micro vessel morphometric measurement of endometrial vascularity. Twenty-five women with unexplained recurrent miscarriage were recruited for 3D-PD and endometrial biopsy on precisely day LH + 7. Immunohistochemistry using vWF was employed to identify micro vessels in endometrial biopsy specimens followed by the use of morphometric technique to measure the mean vessel diameter and volume fractions. The vascularization index (VI), flow index (FI) and vascularization flow index (VFI) assessed by 3D-PD were calculated for both the endometrial and sub-endometrial regions. There were no significant correlations between any of the ultrasonographic measurements (endometrial thickness, endometrial volume, endometrial VI/FI/VFI, sub-endometrial volume, sub-endometrial VI/FI/VFI) and morphometric features (number of micro vessel, mean diameter of micro vessel and volume fraction measurement of vessel). This study indicates that endometrial vascularity assessed by 3D-PD could not be used to reflect changes in micro vessels of the endometrium at the time of embryo implantation in women with unexplained recurrent miscarriage.

http://ift.tt/2r455Ki

Clinical Features of Patients with Basedow's Disease and High Serum IgG4 Levels.

Related Articles

Clinical Features of Patients with Basedow's Disease and High Serum IgG4 Levels.

Intern Med. 2017;56(9):1009-1013

Authors: Torimoto K, Okada Y, Kurozumi A, Narisawa M, Arao T, Tanaka Y

Abstract
Objective IgG4-related disease is a recently characterized condition presenting with high blood IgG4 levels, swelling of organs, and hypertrophic lesions. This disease is associated with thyroid disease, Hashimoto's disease, and Riedel's thyroiditis. However, there is little information on the association between IgG4-related disease and Basedow's disease. We herein defined the clinical features of patients with Basedow's disease and high IgG4 levels. Methods We compared two groups of patients with Basedow's disease (n=72) who had either normal IgG4 levels (<135 mg/dL; n=67) or high IgG4 levels (≥135 mg/dL; n=5 [6.9%], mean IgG4: 206±116 mg/dL, IgG4/IgG ratio: 10.6%±3.3%). Patients Seventy-two newly diagnosed, untreated patients with Basedow's disease. Results Compared to the normal IgG4 group, patients in the high IgG4 group were predominantly male and showed a significantly higher thyroid low-echo score (1.8±0.4 vs. 1.2±0.5) and eosinophil count (363±354/mm(2) vs. 136±122/mm(2)). Five patients had high IgG4 levels: one had a pancreatic lesion, and four had thyroid lesions. Conclusion Patients with Basedow's disease and high IgG4 levels may represent a new subtype of Basedow's disease. Further studies with larger sample sizes are needed.

PMID: 28458304 [PubMed - in process]

http://ift.tt/2qurljF

13 Critical Care Management of Patients With Liver Disease

Publication date: 2018
Source:Zakim and Boyer's Hepatology
Author(s): Phillip Factor, Sammy Saab




http://ift.tt/2r4loab

A novel germline TP53 mutation p.Pro190Arg detected in a patient with lung and bilateral breast cancers

Publication date: September 2017
Source:Advances in Medical Sciences, Volume 62, Issue 2
Author(s): Małgorzata Krześniak, Dorota Butkiewicz, Jadwiga Rachtan, Iwona Matuszczyk, Ewa Grzybowska, Marek Rusin
PurposeLi-Fraumeni syndrome (LFS) is a rare genetic disease with strong predispositions to multiple early-onset neoplasms, mostly sarcomas, breast cancers, brain tumors and adrenocortical carcinomas (LFS core cancers). In most LFS families the germline mutations of TP53 tumor suppressor gene were found. Lung cancer does not belong to the core cancers of LFS, however its higher incidence is observed in families with TP53 mutations. Our aim was to search for TP53 mutations in female lung cancer patients whose clinico-demographic characteristics suggested a probable genetic predisposition to the disease.Materials and methodsThe coding region of TP53 from blood DNA was sequenced using Sanger method. The functioning of detected mutation was tested by luciferase reporter assay.ResultsWe found a nucleotide substitution c.569C>G, p.Pro190Arg, which was not described in the TP53 germline mutation database (http://ift.tt/2r44pEI). The mutation destroys the ability of p53 to transactivate BAX promoter and significantly reduces transactivation potential of p53 toward the promoter of MDM2 gen.ConclusionWe identified novel germline mutation of TP53.



http://ift.tt/2qumWgJ

4 Endometrial Hyperplasia, Estrogen Therapy, and the Prevention of Endometrial Cancer

Publication date: 2018
Source:Clinical Gynecologic Oncology
Author(s): Lisa M. Landrum, Rosemary E. Zuna, Joan L. Walker




http://ift.tt/2qucYvM

Identification and preliminary structure–activity relationships of 1-Indanone derivatives as novel indoleamine-2, 3-dioxygenase 1 (IDO1) inhibitors

Publication date: Available online 10 May 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Dingding Gao, Yingxia Li
Indoleamine 2, 3-dioxygenase 1 (IDO1) plays a vital role in the catabolism of tryptophan along with the kynurenine pathway which is involved in many human diseases including cancer, Alzheimer's disease, etc. In this study, compound 1 bearing a 1-Indanone scaffold was identified as a novel IDO1 inhibitor by structure-based virtual screening, with moderate to good enzymatic and cellular inhibitory activities. Also, surface plasmon resonance analysis validated the direct interaction between compound 1 and IDO1 protein. The preliminary SAR was further explored and the binding mode with IDO1 protein was predicted by experiment along with molecular docking. Subsequent ADME properties of these active compounds were analyzed in silico, and the results showed good pharmacokinetic efficiencies. We believe this study contributes a lot to the structural diversity for the future development of highly potent IDO1 inhibitors.

Graphical abstract

http://ift.tt/2pmsdXj

Synthesis of Νοvel Artemisinin Dimers with Polyamine Linkers and Evaluation of Their Potential as Anticancer Agents

Publication date: Available online 10 May 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): George E. Magoulas, Tzoanna Tsigkou, Lina Skondra, Margarita Lamprou, Panagiota Tsoukala, Vassiliki Kokkinogouli, Evangelia Pantazaka, Dionissios Papaioannou, Constantinos M. Athanassopoulos, Evangelia Papadimitriou
The natural product artemisinin and derivatives thereof are currently considered as the drugs of choice for the treatment of malaria. At the same time, a significant number of such drugs have also shown interesting anticancer activity. In the context of the present research work, artemisinin was structurally modified and anchored to naturally occurring polyamines to afford new artemisinin dimeric conjugates whose potential anticancer activity was evaluated. All artemisinin conjugates tested were more effective than artemisinin itself in decreasing the number of MCF7 breast cancer cells. The effect required conjugation and was not due to the artemisinin analogue or the polyamine, alone or in combination. To elucidate potential mechanism of action, we used the most effective conjugates 6, 7, 9 and 12 and found that they decreased expression and secretion of the angiogenic growth factor pleiotrophin by the cancer cells themselves, and inhibited angiogenesis in vivo and endothelial cell growth in vitro. These data suggest that the new artemisinin dimers are good candidates for the development of effective anticancer agents.

Graphical abstract

http://ift.tt/2pmwbPO

18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain

Publication date: Available online 10 May 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Liang Wang, Jiajun Ye, Yingfang He, Winnie Deuther-Conrad, Jinming Zhang, Xiaojun Zhang, Mengchao Cui, Jörg Steinbach, Yiyun Huang, Peter Brust, Hongmei Jia
We have designed and synthesized a series of indole-based σ2 receptor ligands containing 5,6-dimethoxyisoindoline or 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline as pharmacophore. In vitro competition binding assays showed that all ten ligands possessed low nanomolar affinity (Ki = 1.79–5.23 nM) for σ2 receptors and high subtype selectivity (Ki (σ2)/Ki (σ1) = 56–708). Moreover, they showed high selectivity for σ2 receptor over the vesicular acetylcholine transporter (>1000-fold). The corresponding radiotracers [¹⁸F]16 and [¹⁸F]21 were prepared by an efficient one-pot, two-step reaction sequence with a home-made automated synthesis module, with 10–15% radiochemical yield and radiochemical purity of >99%. Both radiotracers showed high brain uptake and σ2 receptor binding specificity in mice.

Graphical abstract

http://ift.tt/2pmv4Qc

Recent Advances in Racemic Protein Crystallography

Publication date: Available online 10 May 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Bingjia Yan, Linzhi Ye, Weiliang Xu, Lei Liu
Solution of the three-dimensional structures of proteins is a critical step in deciphering the molecular mechanisms of their bioactivities. Among the many approaches for obtaining protein crystals, racemic protein crystallography has been developed as a unique method to solve the structures of an increasing number of proteins. Exploiting unnatural protein enantiomers in crystallization and resolution, racemic protein crystallography manifests two major advantages that are 1) to increase the success rate of protein crystallization, and 2) to obviate the phase problem in X-ray diffraction. The requirement of unnatural protein enantiomers in racemic protein crystallography necessitates chemical protein synthesis, which are hitherto accomplished through solid phase peptide synthesis and chemical ligation reactions. This review highlights the fundamental ideas of racemic protein crystallography and surveys the harvests in the field of racemic protein crystallography over the last five years from early 2012 to late 2016.

Graphical abstract

http://ift.tt/2pmsf1n

Mechanisms and effectivity of sulfate reducing bioreactors using a chitinous substrate in treating mining influenced water

Publication date: 1 September 2017
Source:Chemical Engineering Journal, Volume 323
Author(s): Souhail R. Al-Abed, Patricio X. Pinto, John McKernan, Elisabeth Feld-Cook, Slawomir M. Lomnicki
Mining-influenced water (MIW) is one of the main environmental challenges associated with the mining industry. Passive MIW remediation can be achieved through microbial activity in sulfate-reducing bioreactors (SRBRs), but their actual removal rates depend on different factors, one of which is the substrate composition. Chitinous materials have demonstrated high metal removal rates, particularly for the two recalcitrant MIW contaminants Zn and Mn, but their removal mechanisms need further study. We studied Cd, Fe, Zn, and Mn removal in bioactive and abiotic SRBRs to elucidate the metal removal mechanisms and the differences in metal and sulfate removal rates using a chitinous material as substrate. We found that sulfate-reducing bacteria are effective in increasing metal and sulfate removal rates and duration of operation in SRBRs, and that the main mechanism involved metal precipitation as sulfides. The solid residues provided evidence of the presence of sulfides in the bioactive column, more specifically ZnS, according to XPS analysis. The feasibility of passive treatments with a chitinous substrate could be an important option for MIW remediation.

Graphical abstract

http://ift.tt/2qtWeEH

Photoelectrocatalytic oxidation of metal-EDTA and recovery of metals by electrodeposition with a rotating cathode

Publication date: 15 September 2017
Source:Chemical Engineering Journal, Volume 324
Author(s): Yutong Chen, Xu Zhao, Wei Guan, Di Cao, Tao Guo, Xiufang Zhang, Yan Wang
In this work, a photoelectrocatalytic reactor with a rotating cathode was designed for the destruction of metal complexes and recovery of liberated metal ions. The effects of rotating speed, current density, initial pH and initial Cu-EDTA concentration on the recovery of Cu and destruction of Cu complexes were investigated. At cathode rotation speed of 100rpm, initial pH of 3.18 and current density of 0.5mA/cm², the recovery percentage of Cu and destruction of the Cu complexes were increased to be 75.54% and 74.18% from 38.98% and 37.92% at 0rpm rotation speed within 120min, respectively. Furthermore, the destruction of Co-EDTA, Ni-EDTA and Zn-EDTA complexes using the rotating cathode were investigated. The Co²⁺, Ni²⁺ and Zn²⁺ recovery percentage was increased by 29%, 19% and 18% with the optimal speed of cathode, respectively. The recovered product from the cathodic electroreduction was all crystallized. The treatment performance of the reactor for the first 5 cycles had a slight downward trend, and then the capability of the reactor tended to be stable. The photoelectroctalytic reactor with the rotating cathode exhibited the high efficiency for the recovery of liberated metal ions and destruction of metal-EDTA complexes.

Graphical abstract

http://ift.tt/2quaYmZ

Tunable magnetism of 3d transition metal doped BiFeO3

Publication date: 1 October 2017
Source:Journal of Magnetism and Magnetic Materials, Volume 439
Author(s): S. Lu, C. Li, Y.F. Zhao, Y.Y. Gong, L.Y. Niu, X.J. Liu, T. Wang
Electronic polarization or bond relaxation can effectively alter the electronic and magnetic behavior of materials by doping impurity atom. For this aim, the thermodynamic, electronic and magnetic performances of cubic BiFeO3 have been modulated by the 3d transition metal (TM) dopants (Sc, Ti, V, Cr, Mn, Co, Ni, Cu and Zn) based on the density functional theory. Results show that the doped specimen with low impurity concentration is more stable than that with high impurity concentration. The Mulliken charge values and spin magnetic moments of TM element are making major changes, while those of all host atoms are making any major changes. Especially, it is the linear relation between the spin magnetic moments of TM dopants and the total magnetic moment of doped specimens; thus, the variations of total magnetic moment of doped specimens are decided by the spin magnetic moments of TM dopants, thought the total magnetic moments of doped specimens mainly come from Fe atom and TM dopants. Besides, as double TM atoms substitution the Fe atoms, the Sc-, Ti-, Mn-, Co- and Zn-doped specimens show AFM state, while the V-, Cr-, Ni- and Cu-doped specimens show FM state.



http://ift.tt/2r4aHnT

MEN2 Syndrome-Related Medullary Thyroid Carcinoma with Focal Tyrosine Hydroxylase Expression: Does It Represent a Hybrid Cellular Phenotype or Functional State of Tumor Cells?

http://ift.tt/2pBjL2G

Androgen production in pediatric adrenocortical tumors may occur via both the classic and/or the alternative backdoor pathway

Publication date: Available online 10 May 2017
Source:Molecular and Cellular Endocrinology
Author(s): Nesa Marti, Jana Malikova, José A. Galván, Maude Aebischer, Marco Janner, Zdenek Sumnik, Barbora Obermannova, Genevieve Escher, Aurel Perren, Christa E. Flück
Children with adrenocortical tumors (ACTs) often present with virilization due to high tumoral androgen production, with dihydrotestosterone (DHT) as most potent androgen. Recent work revealed two pathways for DHT biosynthesis, the classic and the backdoor pathway. Usage of alternate routes for DHT production has been reported in castration-resistant prostate cancer, CAH and PCOS. To assess whether the backdoor pathway may contribute to the virilization of pediatric ACTs, we investigated seven children suffering from androgen producing tumors using steroid profiling and immunohistochemical expression studies. All cases produced large amounts of androgens of the classic and/or backdoor pathway. Variable expression of steroid enzymes was observed in carcinomas and adenomas. We found no discriminative pattern. This suggests that enhanced androgen production in pediatric ACTs is the result of deregulated steroidogenesis through multiple steroid pathways. Thus future treatments of ACTs targeting androgen overproduction should consider these novel steroid production pathways.

Graphical abstract

http://ift.tt/2qu6hJT

Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Publication date: Available online 10 May 2017
Source:Molecular and Cellular Endocrinology
Author(s): Lei Du, Meng Hao, Chengcheng Li, Wenya Wu, Wenwen Wang, Zhongxuan Ma, Tingting Yang, Nan Zhang, Adelusi Temitope Isaac, Xia Zhu, Ying Sun, Qian Lu, Xiaoxing Yin
Diabetic cataract (DC), an identified life-threatening secondary complication of diabetes mellitus, has proven to be a dilemma because of its multifactorial caused and progression. An increasing number of studies have shown that in addition to the maillard reaction, enhanced polyol pathway, and oxidative insults, epithelial mesenchymal transition (EMT) is related to the prevalence of DC. Quercetin, a classic flavonoid with multiple pharmacological effects has been reported to possess therapeutic efficacy in the management and treatment of this disease. However, the mechanism underlying its therapeutic efficacy in EMT of lens epithelial cells (SRA01/04) and contribution to resolving DC remains a mystery. Therefore, in this study, we investigated the effects of quercetin on EMT of SRA01/04 and high-glucose (HG)-induced lens opacity accompanied by lens fibrosis induced by type-1 diabetes. Furthermore, we sought to clarify the specific mechanisms underlying these effects. At week 14 after streptozotocin (STZ) intraperitoneal administration, diabetic rats showed lens opacity accompanied with diminished antioxidant function, enhanced polyol pathway activity, and non-enzymatic glycation. Western blotting confirmed EMT in rat SRA01/04 cells with significantly increased α-smooth muscle actin (α-SMA) and decreased E-cadherin expressions. Treatment of the lens with quercetin ameliorated the oxidative stress, inhibited aldose reductase (AR) activation, reduced advanced glycation end product (AGE) production, and finally suppressed EMT in the early stages. Our in vitro results showed that high-glucose activated the transforming growth factor-β2/phosphoinositide 3-kinase/protein kinase B (TGF-β2/PI3K/Akt) signalling and EMT in SRA01/04 cells. Further, induced oxidative stress, activation of aldose reductase, and accumulation of advanced glycation end products were also involved in this process. Quercetin was potent enough to effectively ameliorate the high glucose (HG)-induced EMT of SRA01/04 cells by inhibiting the activation of TGF-β2/PI3K/Akt, enhancing the antioxidant capacity, inhibiting AR activity, and reducing AGE production. From the whole animal to tissues, and finally the cellular level, our results provide considerable evidence of the therapeutic potential of quercetin for DC. This might be due to its inhibition of EMT mediated through inhibition of the TGF-β/PI3K/Akt pathway.



http://ift.tt/2r4jiHi

Alterations of DNA methylation in parathyroid tumors

Publication date: Available online 10 May 2017
Source:Molecular and Cellular Endocrinology
Author(s): V. Guarnieri, L.A. Muscarella, C. Verdelli, S. Corbetta
Parathyroid tumors are common endocrine neoplasias associated with primary hyperparathyroidism, a metabolic disorder characterized by parathormone hypersecretion. Parathyroid neoplasia are frequently benign adenomas or multiple glands hyperplasia, while malignancies are rare. The epigenetic scenario in parathyroid tumors has just begun to be decoded: DNA methylation, histones and chromatin modifiers expression have been investigated so far. The main findings suggest that DNA methylation and chromatin remodeling are active and deregulated in parathyroid tumors, cooperating with genetic alterations to drive the tumor phenotype: the tumor suppressors menin and parafibromin, involved in parathyroid tumorigenesis, interact with chromatin modifiers, defining distinct epigenetic derangements. Many epigenetic alterations identified in parathyroid tumors are common to those in human cancers; moreover, some aspects of the epigenetic profile resemble epigenetic features of embryonic stem cells. Epigenetic profile may contribute to define the heterogeneity of parathyroid tumors and to provide targets for new therapeutic approaches.



http://ift.tt/2qu5ZTA

The In Vitro Influence of a Genetic Superoxide-Hydrogen Peroxide Imbalance on Immunosenescence

Rejuvenation Research , Vol. 0, No. 0.


http://ift.tt/2q4KK9G

Scholar : Ειδοποίηση Μελετητή - [ CPAP ]

Ειδοποίηση Μελετητή:[ CPAP ]

[PDF] The Association Between High Flow Nasal Cannula Therapy and Intubation in Acute Respiratory Failure Patients, A Single Center Retrospective Analysis

P Nolan - 2017

... 3 Design 3 Subjects 3 Data Collection 4 Plan for Analysis 5 Results 5 Group 1: HFNC vs. CPAP
or BiPAP and Intubation 5 Group 2 HFNC vs. CPAP or BiPAP and Re-intubation 7 Discussion
7 Findings 7 Limitations and Strengths 9 Call for Future Research 9 Conclusion 9 ...

[PDF] Experiences of caregivers of infants who have been on bubble continuous positive airway pressure at Queen Elizabeth Central Hospital, Malawi: A descriptive …

MJ Gondwe, B Gombachika, MD Majamanda - Malawi Medical Journal, 2017

... Introduction Bubble continuous positive airway pressure (bCPAP) delivers continuous positive
pressure (CPAP) to the airways of spontaneously breathing patients throughout the respiratory
cycle.1 It is effective in treating severe respiratory distress due to respiratory distress ...

P4 medicine approach to obstructive sleep apnoea

DC Lim, K Sutherland, PA Cistulli, AI Pack - Respirology, 2017

... to participate in their own care from screening for OSA (snoring and apnoea apps) to monitoring
response to therapy (sleep monitoring, blood pressure, oxygen saturation and heart rate) as well
as monitoring their own continuous positive airway pressure (CPAP) compliance. ...

Acute pulmonary oedema

D Sprigings, JB Chambers - Acute Medicine‐A Practical Guide to the Management …, 2018

... The modes of ventilation include non-invasive ventilator support with continuous
positive airways pressure (CPAP) and endotracheal intubation and mechanical
ventilation. Get PDF : This Chapter (4182K). More content like this. ...

Drowning

F Garnham - Acute Medicine‐A Practical Guide to the Management …, 2018

Skip to Main Content. ...

[PDF] Update for Canadian NRP providers: A case-based review

E Finan, DM Campbell, K Aziz, PJ McNamara

... pressure (PEEP) is recom mended when resuscitating the preterm infant, al though recent
guidelines do not recommend a particu lar device.[1] If the baby is breathing spontaneously at
an adequate respiratory rate, continuous positive air way pressure (CPAP) is suggested for ...

Sound levels in a neonatal intensive care unit significantly exceeded recommendations, especially inside incubators

J Parra, A de Suremain, FB Audeoud, A Ego… - Acta Paediatrica

... infusion and feeding pumps, Babylog 8000 and VN 500 ventilators (Dräger Medical, Lübeck,
Germany), InfantFlow SiPAC continuous positive airway pressure (CPAP) devices or Bird ... analysed,
such as the type of respiratory support (tracheal ventilation, CPAP, HFNC) the ...

[DOC] CLINICO-ETIOLOGICAL EVALUATION OF RESPIRATORY DISTRESS IN NEWBORN AND ITS IMMEDIATE OUTCOME ADMITTED IN A TERTIARY CARE TEACHING …

AT Reddy, BR Kumar, M Harika - SEPSIS

... Treatment details like respiratory support (Oxygen therapy, CPAP, Mechanical ventilation),
surfactant and surgical interventions performed were documented. ... Table No.16 TREATMENT
INTERVENTION. ETIOLOGY, FREQUENCY, SURGICAL, CPAP, VENTILATOR, SURFACTANT ...

PULSE WAVE ANALYZER

M Tanishima, T Sakai - US Patent 20,170,105,630, 2017

... The artificial respirator has ventilation modes such as the A/C (Assist Control), the SIMV
(Synchronized Intermittent Mandatory Ventilation), the PSV (Pressure Support Ventilation),
and the CPAP (Continuous Positive Airway Pressure). ...

The treatment of chronic heart failure–current guidelines and their limitations

G Ertl, CE Angermann - PHARMAKON, 2017

... Zwei aktuel- le Studien zur Behandlung der komorbiden Depression, bzw. komorbiden zentralen
Schlafapnoe mit einem An- tidepressivum, bzw. einer CPAP-Beatmung waren aber negativ mit
deutlichen Hinweisen auf eine Verschlech- terung durch die Therapie [21, 22]. ...

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Scholar : Ειδοποίηση Μελετητή - [ Decannulat

Ειδοποίηση Μελετητή:[ Decannulation ]

[PDF] The application of the modified surgical wound dressing in wound care after tracheotomy☆

M Feng, Y Wu, J Zhu, X Wu - 2017

... Received 8 August 2016, Accepted 21 March 2017, Published online 24 April 2017 Abstract
--Introduction: This study was performed to observe the efficacy of a modified surgical wound
dressing applied as part of decannulation wound care after tracheotomy. ...

[PDF] Efficacy of the "Head-Up Position" in Returning Cardiopulmonary Bypass Blood to the Patient and Reducing the Required Blood Transfusion: A Randomized Trial

R Azarfarin, M Dashti, Z Totonchi, M Ziyaeifard…

... relative reduction of target hematocrit for transfusion, optimal surgical homeostasis, reducing
cardiopulmonary bypass (CPB) time, ultrafiltration during CPB, and finally returning the remaining
volume of reservoir and the tubing system just before aortic decannulation at the end ...

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