Scholar : Oncology Letters - Volume:12 Number:4

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TABLE OF CONTENTS October 2016 Volume 12 Issue 4

Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets (Review) Nadège Kindt, Fabrice Journe, Guy Laurent, Sven Saussez View Abstract ❯

Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review) Luisa Vicari, Cristina Colarossi, Dario Giuffrida, Ruggero De Maria, Lorenzo Memeo View Abstract ❯

Re-irradiation alternatives for recurrent high-grade glioma (Review) Yuanli Dong, Chengrui Fu, Hui Guan, Tianyi Zhang, Zicheng Zhang, Tao Zhou, Baosheng Li View Abstract ❯

Why man's best friend, the dog, could also benefit from an anti‑HER-2 vaccine (Review) Judit Fazekas, Irene Fürdös, Josef Singer, Erika Jensen‑Jarolim View Abstract ❯

Role of Yes-associated protein in cancer: An update (Review) Ramazan Abylkassov, Yingqiu Xie View Abstract ❯

Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches (Review) Wen‑Juan Huang, Wei‑Wei Chen, Xia Zhang View Abstract ❯

MicroRNAs and PIWI-interacting RNAs in oncology (Review) Yong Liu View Abstract ❯

Thermal ablation in cancer (Review) Yong Liu, Cheng-Song Cao, Yang Yu, Ya-Meng Si View Abstract ❯

Expression of microRNA‑181 determines response to treatment with azacitidine and predicts survival in elderly patients with acute myeloid leukaemia Aleksandra Butrym, Justyna Rybka, Dagmara Baczyńska, Rafał Poręba, Grzegorz Mazur, Kazimierz Kuliczkowski View Abstract ❯

miR‑186 suppressed CYLD expression and promoted cell proliferation in human melanoma Haijiang Qiu, Suirong Yuan, Xiaohe Lu View Abstract ❯

Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5 Ying Wang, Yongjun Zhang, Meiyu Fang, Wenglong Bao, Dehou Deng View Abstract ❯

Whole‑exome sequencing identifies variants in invasive pituitary adenomas Xiaolei Lan, Hua Gao, Fei Wang, Jie Feng, Jiwei Bai, Peng Zhao, Lei Cao, Songbai Gui, Lei Gong, Yazhuo Zhang View Abstract ❯

Mechanism analysis of colorectal cancer according to the microRNA expression profile Hong Li, Huichao Zhang, Gang Lu, Qingjing Li, Jifeng Gu, Yuan Song, Shejun Gao, Yawen Ding View Abstract ❯

Antitumor effects of the hyaluronan inhibitor 4-methylumbelliferone on pancreatic cancer Eri Yoshida, Daisuke Kudo, Hayato Nagase, Hiroshi Shimoda, Shinichiro Suto, Mika Negishi, Ikuko Kakizaki, Masahiko Endo, Kenichi Hakamada View Abstract ❯

Celecoxib exhibits an anti‑gastric cancer effect by targeting focal adhesion and leukocyte transendothelial migration‑associated genes Guo‑Hua Jin, Wei Xu, Yang Shi, Li‑Bo Wang View Abstract ❯

Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion Friederike Hoellen, Annika Waldmann, Constanze Banz‑Jansen, Achim Rody, Maria Heide, Frank Köster, Julika Ribbat‑Idel, Christoph Thorns, Maximilian Gebhard, Martina Oberländer, Jens Habermann, Marc Thill View Abstract ❯

High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer Xiangxiang Zheng, Haibo Hu, Shiting Li View Abstract ❯

Combined use of free light chain and heavy/light chain ratios allow diagnosis and monitoring of patients with monoclonal gammopathies: Experience of a single institute, with three exemplar case reports Alfredo Gagliardi, Claudio Carbone, Angela Russo, Rosanna Cuccurullo, Anna Lucania, Paola Cioppa, Gabriella Misso, Michele Caraglia, Catello Tommasino, Lucia Mastrullo View Abstract ❯

Caveolin‑1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters Xuening Zhao, Gang Yu, Xuemin Yu, Juan Wang, Xinliang Pan View Abstract ❯

Identification of genes involved in Epstein‑Barr virus‑associated nasopharyngeal carcinoma Junguo Wang, Fang Mei, Xia Gao, Shoulin Wang View Abstract ❯

Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer Jing Zhang, Kundong Zhang, Lisheng Zhou, Weidong Wu, Tao Jiang, Jun Cao, Kejian Huang, Zhengjun Qiu, Chen Huang View Abstract ❯

Entrance of the Tat protein of HIV-1 into human uterine cervical carcinoma cells causes upregulation of HPV-E6 expression and a decrease in p53 protein levels Giovanni Barillari, Clelia Palladino, Ilaria Bacigalupo, Patrizia Leone, Mario Falchi, Barbara Ensoli View Abstract ❯

Genetic landscape of a case of extraovarian peritoneal serous papillary carcinoma Zhongping Cheng, Weihong Yang, Jing Guo, Ning Luo, Li Chen, Yan Xie, Xiaoyan Qu, Liping Hu, Hong Dai, Xiaoming Zuo View Abstract ❯

Matrix metalloproteinase expression and molecular interaction network analysis in gastric cancer Jianting Xu, Changyong E, Yongfang Yao, Shuangchun Ren, Guoqing Wang, Haofan Jin View Abstract ❯

SREBP‑1 is an independent prognostic marker and promotes invasion and migration in breast cancer Jisheng Bao, Liping Zhu, Qi Zhu, Jianhua Su, Menglan Liu, Wei Huang View Abstract ❯

Negative pathology of ureteral carcinoma significantly delaying the diagnosis of the primary tumor of osteoblastic metastases: A case report and review of the literature Ya‑Lan Wu, Yong‑Mei Liu, Hui‑Jiao Chen, Yong‑Sheng Wang, You Lu View Abstract ❯

Increase of T and B cells and altered BACH2 expression patterns in bone marrow trephines of imatinib‑treated patients with chronic myelogenous leukaemia Maximilian Von Laffert, Mathias Hänel, Manfred Dietel, Ioannis Anagnostopoulos, Korinna Jöhrens View Abstract ❯

Expression and prognostic significance of CTBP2 in human gliomas Yong Wang, Shusheng Che, Gang Cai, Yuchao He, Jialei Chen, Wei Xu View Abstract ❯

Association between SET expression and glioblastoma cell apoptosis and proliferation Kunyan He, Lihong Shi, Tingting Jiang, Qiang Li, Yao Chen, Chuan Meng View Abstract ❯

Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance Jing Zhang, Xiao‑Yu Chen, Ke‑Jian Huang, Wei‑Dong Wu, Tao Jiang, Jun Cao, Li‑Sheng Zhou, Zheng‑Jun Qiu, Chen Huang View Abstract ❯

Ultrasonic features of papillary thyroid microcarcinoma coexisting with a thyroid abnormality Bo Li, Yaqiong Zhang, Ping Yin, Jian Zhou, Tian'an Jiang View Abstract ❯

Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene Xiaofeng Wang, Lu Chen, Zhongdi Xiao, Yali Wang, Tiemei Liu, Tianfu Zhang, Yucheng Zhang View Abstract ❯

Effect of API‑1 and FR180204 on cell proliferation and apoptosis in human DLD‑1 and LoVo colorectal cancer cells Atiye Saglam, Ebru Alp, Zubeyir Elmazoglu, Emine Menevse View Abstract ❯

Clinical analysis of 47 cases of solitary fibrous tumor Wei Ge, De‑Cai Yu, Gang Chen, Yi‑Tao Ding View Abstract ❯

Evaluation of automated breast volume scanner for breast conservation surgery in ductal carcinoma in situ Anqian Huang, Luoxi Zhu, Yanjuan Tan, Jian Liu, Jingjing Xiang, Qingqing Zhu, Lingyun Bao View Abstract ❯

Stem cell growth factor receptor in canine vs. feline osteosarcomas Birgitt Wolfesberger, Andrea Fuchs‑Baumgartinger, Juraj Hlavaty, Florian Meyer, Martin Hofer, Ralf Steinborn, Christiane Gebhard, Ingrid Walter View Abstract ❯

The HIV‑protease inhibitor saquinavir reduces proliferation, invasion and clonogenicity in cervical cancer cell lines Elisabetta Bandiera, Paola Todeschini, Chiara Romani, Laura Zanotti, Eugenio Erba, Benedetta Colmegna, Eliana Bignotti, Alessandro Santin, Enrico Sartori, Franco Odicino, Sergio Pecorelli, Renata Tassi, Antonella Ravaggi View Abstract ❯

Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer Xiao-Ming Shen, You-You Xia, Lian Lian, Chong Zhou, Xiang-Li Li, Shu-Guang Han, Yan Zheng, Fei-Ran Gong, Min Tao, Zhong-Qi Mao, Wei Li View Abstract ❯

Significance of stem cell marker Nanog gene in the diagnosis and prognosis of lung cancer Zeng Liu, Jing Zhang, Honggang Kang, Guiming Sun, Baozhong Wang, Yanwen Wang, Mengxiang Yang View Abstract ❯

Hepatocellular carcinoma stem cell‑like cells are enriched following low‑dose 5‑fluorouracil chemotherapy Yongqiang Zhan, Lisha Mou, Kangwen Cheng, Chengyou Wang, Xuesong Deng, Junren Chen, Zhibing Fan, Yong Ni View Abstract ❯

Comparison of the accuracy of 99mTc‑3P4‑RGD2 SPECT and CT in diagnosing solitary pulmonary nodules Haishan Zhang, Shi Gao, Bin Chen, Guanghui Cheng View Abstract ❯

Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma Lei Deng, Pengju Xiong, Yunhui Luo, Xiao Bu, Suokai Qian, Wuzhao Zhong View Abstract ❯

miRNA‑335 and miRNA‑182 affect the occurrence of tongue squamous cell carcinoma by targeting survivin Deming Ou, Ying Wu, Jun Liu, Xiaomei Lao, Sien Zhang, Guiqing Liao View Abstract ❯

miR‑101 inhibits glioma cell invasion via the downregulation of COX‑2 Chunyang Ma, Chuanyi Zheng, Enqi Bai, Kun Yang View Abstract ❯

Glioma coexisting with angiographically occult cerebrovascular malformation: A case report Junhui Chen, Lei Chen, Chunlei Zhang, Jianqing He, Peipei Li, Jingxu Zhou, Jun Zhu, Yuhai Wang View Abstract ❯

Effects of ZNF139 on gastric cancer cells and mice with gastric tumors Hong‑Feng Nie, Yong Li, Zhen‑Xing Li, Ji‑Xing Mu, Jin‑Sheng Wang View Abstract ❯

Prognostic significance of CD168 overexpression in colorectal cancer Ke Wang, Tao Zhang View Abstract ❯

Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells Tomohiko Fukuda, Katsutoshi Oda, Osamu Wada‑Hiraike, Kenbun Sone, Kanako Inaba, Yuji Ikeda, Chinami Makii, Aki Miyasaka, Tomoko Kashiyama, Michihiro Tanikawa, Takahide Arimoto, Tetsu Yano, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii View Abstract ❯

MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc Rana Youness, Hend El-Tayebi, Reem Assal, Karim Hosny, Gamal Esmat, Ahmed Abdelaziz View Abstract ❯

17AAG‑induced internalisation of HER2‑specific Affibody molecules Lovisa Göstring, Sture Lindegren, Lars Gedda View Abstract ❯

Suppression of the Eag1 potassium channel sensitizes glioblastoma cells to injury caused by temozolomide Thais Sales, Fernando Resende, Natália Chaves, Simoneide Titze-De-Almeida, Sônia Báo, Marcella Brettas, Ricardo Titze‑De‑Almeida View Abstract ❯

Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients Katarina Kalavska, Michal Chovanec, Miriam Zatovicova, Martina Takacova, Paulina Gronesova, Daniela Svetlovska, Magdalena Baratova, Vera Miskovska, Jana Obertova, Patrik Palacka, Jan Rajec, Zuzana Sycova‑Mila, Zuzana Cierna, Karol Kajo, Stanislav Spanik, Pavel Babal, Jozef Mardiak, Silvia Pastorekova, Michal Mego View Abstract ❯

Cisplatin‑resistant osteosarcoma cells possess cancer stem cell properties in a mouse model Jian Yang, Weichun Guo, Lu Wang, Ling Yu, Hongjun Mei, Shuo Fang, Peng Ji, Yang Liu, Gaiwei Liu, Qi Song View Abstract ❯

Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer Qingyu Shi, Tong Liu, Xianyu Zhang, Jingshu Geng, Xiaohui He, Ming Nu, Da Pang View Abstract ❯

Methylation pattern of CDH1 promoter and its association with CDH1 gene expression in cytological cervical specimens Veronika Holubeková, Andrea Mendelová, Marián Grendár, Sandra Meršaková, Ivana Kapustová, Karin Jašek, Andrea Vaňochová, Jan Danko, Zora Lasabová View Abstract ❯

Cerebellar hemangioblastoma mimicking an aneurysm: A case report and literature review Yu‑Chen Ji, Yan Li, Jing‑Xia Hu, Hong‑Bo Zhang, Peng‑Xiang Yan, Huan‑Cong Zuo View Abstract ❯

Co‑evolution of tumor‑associated macrophages and tumor neo‑vessels during cervical cancer invasion Shuting Jiang, Yuehong Yang, Min Fang, Xianglang Li, Xiuxue Yuan, Jingping Yuan View Abstract ❯

Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells Ying Xu, Dongming Wu, Yuanchun Fan, Peigeng Li, Hongfei Du, Jiao Shi, Dan Wang, Xiaoping Zhou View Abstract ❯

Ki‑67 is overexpressed in human laryngeal carcinoma and contributes to the proliferation of HEp2 cells Yanxia Bai, Yuan Shao, Huajing Li, Wanli Xue, Fang Quan, Shengli Wu View Abstract ❯

BCAT1 promotes tumor cell migration and invasion in hepatocellular carcinoma Meng Xu, Qingquan Liu, Yuli Jia, Kangsheng Tu, Yingmin Yao, Qingguang Liu, Cheng Guo View Abstract ❯

Genetic analysis and clinical investigation of a pedigree with multiple endocrine neoplasia type 2A: A case report Hong‑Jin Zou, Yu‑Shu Li, Zhong‑Yan Shan View Abstract ❯

Perioperative stroke in a patient undergoing surgery for oral cancer: A case report Shintaro Sukegawa, Takahiro Kanno, Kengo Kanai, Toshiko Mandai, Akane Shibata, Yuka Takahashi, Yuji Hirata, Yoshihiko Furuki View Abstract ❯

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis Hong Chen, Jingjing Wang, Hong Yang, Dan Chen, Panpan Li View Abstract ❯

SPAG9 is overexpressed in osteosarcoma, and regulates cell proliferation and invasion through regulation of JunD Chi Xiao, Lin Fu, Chongnan Yan, Fenyong Shou, Qi Liu, Lei Li, Shaoqian Cui, Jingzhu Duan, Guoxin Jin, Jianhua Chen, Yuanming Bian, Xu Wang, Huan Wang View Abstract ❯

Tazarotene‑induced gene 2 is associated with poor survival in non‑small cell lung cancer Qi Cai, Zhongwei Huang, Lei Qi, Ting Wang, Yanbo Shen, Jian'an Huang View Abstract ❯

Functional redundancy of the Notch pathway in ovarian cancer cell lines Fernanda Silva, Ana Félix, Jacinta Serpa View Abstract ❯

Primitive neuroectodermal tumor originating from the lung: A case report Xin Jin, Jianfeng Cao, Yong Liu, Fang Bian, Qingqing Zhao, Yan Wang, Xu Lv, Yayong Huang View Abstract ❯

Multidisciplinary collaboration in gallbladder carcinoma treatment: A case report and literature review Zheng‑Yun Zou, Jing Yan, Yu‑Zheng Zhuge, Jun Chen, Xiao‑Ping Qian, Bao‑Rui Liu View Abstract ❯

V8 induces apoptosis and the endoplasmic reticulum stress response in human multiple myeloma RPMI 8226 cells via the PERK‑eIF2α‑ATF4 signaling pathway Yaping Zhong, Yonggang Zhang, Ping Wang, Hongxiu Gao, Chunling Xu, Hui Li View Abstract ❯

Expression of early growth response gene‑1 in precancerous lesions of gastric cancer Seon‑Young Park, Ji‑Young Kim, Su‑Mi Lee, Jin Chung, Kyung‑Hwa Lee, Chung‑Hwan Jun, Chang‑Hwan Park, Hyun‑Soo Kim, Sung‑Kyu Choi, Jong‑Sun Rew, Young‑Do Jung, Yong Lee View Abstract ❯

Paraneoplastic Morvan's syndrome following surgical treatment of recurrent thymoma: A case report Edvina Galié, Rosaria Renna, Domenico Plantone, Andrea Pace, Mirella Marino, Bruno Jandolo, Tatiana Koudriavtseva View Abstract ❯

Molecular expression of vascular endothelial growth factor, prokineticin receptor‑1 and other biomarkers in infiltrating canalicular carcinoma of the breast Angélica Morales, Sumiko Morimoto, Felipe Vilchis, Natsuko Taniyama, Claudia Bautista, Carlos Robles, Enrique Bargalló View Abstract ❯

Clinicopathological analysis of CD44 and CD24 expression in invasive breast cancer Min Jang, Hyun Kang, Ki Jang, Seung Paik, Wan Kim View Abstract ❯

Fluorescence in situ hybridization testing of chromosomes 6, 8, 9 and 11 in melanocytic tumors is difficult to automate and reveals tumor heterogeneity in melanomas Arnaud Uguen, Marie Uguen, Matthieu Talagas, Eric Gobin, Pascale Marcorelles, Marc De Braekeleer View Abstract ❯

Killian‑Jamieson diverticulum mimicking a calcified thyroid nodule on ultrasonography: A case report and literature review Li Cao, Junna Ge, Donghui Zhao, Shangtong Lei View Abstract ❯

Novel dynamin 2 mutations in adult T‑cell acute lymphoblastic leukemia Zheng Ge, Min Li, Gang Zhao, Lichan Xiao, Yan Gu, Xilian Zhou, Michael Yu, Jianyong Li, Sinisa Dovat, Chunhua Song View Abstract ❯

ABCG2 expression in colorectal adenocarcinomas may predict resistance to irinotecan Hoang Tuy, Hisanori Shiomi, Ken Mukaisho, Shigeyuki Naka, Tomoharu Shimizu, Hiromichi Sonoda, Eiji Mekata, Yoshihiro Endo, Yoshimasa Kurumi, Hiroyuki Sugihara, Masaji Tani, Tohru Tani View Abstract ❯

Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway Wen Zheng, Shiliu Lu, Haolei Cai, Muxing Kang, Wenjie Qin, Chao Li, Yulian Wu View Abstract ❯

Misdiagnosed infantile rhabdomyofibrosarcoma: A case report Tao Pan, Ken Chen, Run‑Song Jiang, Zheng‑Yan Zhao View Abstract ❯

Aneurysmal bone cyst of the metatarsal: A case report Jiangyinzi Shang, Runsheng Guo, Ping Zhan, Chuwen Chen, Jing Kan, Hucheng Liu, Min Dai View Abstract ❯

Primary gastrointestinal stromal tumor of the liver: A case report and review of the literature Xiaobin Cheng, Dong Chen, Wenbin Chen, Qinsong Sheng View Abstract ❯

Immunohistochemical patterns in the differential diagnosis of rhinopharyngeal granulocytic sarcoma Elena Cantone, Michele Cavaliere, Antonella Di Lullo, Elia Guadagno, Maurizio Iengo View Abstract ❯

Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B‑cell lymphoma from high and low endemic infectious disease regions Therese Högfeldt, Crystal Jaing, Kevin Mc Loughlin, James Thissen, Shea Gardner, Abeer Bahnassy, Baback Gharizadeh, Joachim Lundahl, Anders Österborg, Anna Porwit, Abdel‑Rahman Zekri, Hussein Khaled, Håkan Mellstedt, Ali Moshfegh View Abstract ❯

Iodine‑125 irradiation inhibits invasion of gastric cancer cells by reactivating microRNA‑181c expression Yong Yang, Zhen‑Huan Ma, Xiao‑Gang Li, Wan‑Fu Zhang, Jia Wan, Ling‑Juan Du, Guo‑Jian Li, Guo‑Kai Yang, Ping Lu View Abstract ❯

Leucine zipper, down regulated in cancer‑1 gene expression in prostate cancer Michele Salemi, Nunziata Barone, Sandro La Vignera, Rosita Condorelli, Domenico Recupero, Antonio Galia, Filippo Fraggetta, Anna Aiello, Pietro Pepe, Roberto Castiglione, Enzo Vicari, Aldo Calogero View Abstract ❯

IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report Thomas Greuter, Martin Browne, Corina Dommann‑Scherrer, Daniel Binder, Christoph Renner, Ursula Kapp View Abstract ❯

Aspirin may inhibit angiogenesis and induce autophagy by inhibiting mTOR signaling pathway in murine hepatocarcinoma and sarcoma models Qianqian Zhao, Zhaopeng Wang, Zhaoxia Wang, Licun Wu, Weidong Zhang View Abstract ❯

Promoter methylation and downregulated expression of the TBX15 gene in ovarian carcinoma Gaia Gozzi, Sonia Chelbi, Paola Manni, Loredana Alberti, Sergio Fonda, Sara Saponaro, Luca Fabbiani, Francesco Rivasi, Jean Benhattar, Lorena Losi View Abstract ❯

Soluble purified recombinant C2ORF40 protein inhibits tumor cell growth in vivo by decreasing telomerase activity in esophageal squamous cell carcinoma Linwei Li, Xiaoyan Li, Wenyu Wang, Tianhui Gao, Yun Zhou, Shixin Lu View Abstract ❯

Rapid increase in cystic volume of an anaplastic astrocytoma misdiagnosed as neurocysticercosis: A case report Hong‑Jiang Li, Hong‑Xiu Han, Dong‑Fu Feng View Abstract ❯

4‑isothiocyanate‑2, 2, 6, 6‑tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation Yuanyuan Liu, Jing Gao, Shuangsheng Huang, Lamei Hu, Zhiqiang Wang, Zheyuan Wang, Xiao Chen, Xiaoyu Zhang, Wenguang Li View Abstract ❯

Long non-coding RNA H19 promotes the proliferation of fibroblasts in keloid scarring Jie Zhang, Cai Liu, Yun Wan, Li Peng, Wen Li, Jia Qiu View Abstract ❯

Thymoquinone chemosensitizes colon cancer cells through inhibition of NF‑κB Lida Zhang, Yangqiu Bai, Yuxiu Yang View Abstract ❯

RNA‑seq analysis identifies key long non‑coding RNAs connected to the pathogenesis of alcohol‑associated head and neck squamous cell carcinoma Vicky Yu, Pranav Singh, Elham Rahimy, Hao Zheng, Selena Kuo, Elizabeth Kim, Jessica Wang‑Rodriguez, Weg Ongkeko View Abstract ❯

Association of FOXM1 expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker Nadja Apelt, Jochen Hubertus, Doris Mayr, Norbert Graf, Rhoikos Furtwängler, Dietrich Von Schweinitz, Roland Kappler View Abstract ❯

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma Jieyu Wang, Nan Jia, Qing Li, Chao Wang, Xiang Tao, Keqin Hua, Weiwei Feng View Abstract ❯

Radial forearm and forehead flap reconstruction following resection of a nasal arteriovenous malformation: A case report Chih‑Shin Lin, Yung‑Song Lin, Bor‑Shyh Lin, Ching‑Feng Lien, Ching‑Feng Liu View Abstract ❯

Investigation of the association between mitochondrial DNA and p53 gene mutations in transitional cell carcinoma of the bladder Tuba Avcilar, Deniz Kirac, Deniz Ergec, Gulsah Koc, Korkut Ulucan, Zehra Kaya, Elif Kaspar, Levent Turkeri, Ahmet Guney View Abstract ❯

Anti‑cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin‑1 in prostate cancer Wen‑Tao Gai, Da‑Peng Yu, Xin‑Sheng Wang, Pei‑Tao Wang View Abstract ❯

Side population cells from long-term passage non-small cell lung cancer cells display loss of cancer stem cell-like properties and chemoradioresistance Hao Gu, Xin‑Yu Wu, Rui‑Tai Fan, Xin Wang, You‑Zhong Guo, Rui Wang View Abstract ❯

Eupatilin induces human renal cancer cell apoptosis via ROS‑mediated MAPK and PI3K/AKT signaling pathways Wei‑Feng Zhong, Xiao‑Hong Wang, Bin Pan, Feng Li, Lu Kuang, Ze‑Xuan Su View Abstract ❯

Inhibition of γ‑secretase activity synergistically enhances tumour necrosis factor‑related apoptosis‑inducing ligand induced apoptosis in T‑cell acute lymphoblastic leukemia cells via upregulation of death receptor 5 Lisa Greene, Seema Nathwani, Daniela Zisterer View Abstract ❯

Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1 Deyao Wu, Xiaobing Niu, Huixing Pan, Yunfeng Zhou, Zichun Zhang, Ping Qu, Jian Zhou View Abstract ❯

A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli‑mediated transcription in pancreatic cancer cells Hwa Lee, Qian Wu, Hua Li, Gyu‑Un Bae, An Kim, Jae‑Ha Ryu View Abstract ❯

Anticancer effect of deoxypodophyllotoxin induces apoptosis of human prostate cancer cells Sheng Hu, Qiang Zhou, Wan‑Rui Wu, Yi‑Xing Duan, Zhi‑Yong Gao, Yuan‑Wei Li, Qiang Lu View Abstract ❯

Rescuing defective tumor‑infiltrating T‑cell proliferation in glioblastoma patients Song Han, Enlong Ma, Xiaonan Wang, Chunyong Yu, Tao Dong, Wen Zhan, Xuezhong Wei, Guobiao Liang, Sizhe Feng View Abstract ❯

Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer Carsten Nieder, Ellinor Haukland, Bård Mannsåker, Jan Norum View Abstract ❯

Metastatic extraskeletal Ewing's sarcoma treated with trabectedin: A case report Jorge Hernando‑Cubero, Pilar Sanz‑Moncasi, Alba Hernández‑García, Isabel Pajares‑Bernard, Javier Martínez‑Trufero View Abstract ❯

Contrary melanoma‑associated antigen‑A expression at the tumor front and center: A comparative analysis of stage I and IV head and neck squamous cell carcinoma Stefan Hartmann, Muna Brisam, Stephan Rauthe, Oliver Driemel, Roman Brands, Andreas Rosenwald, Alexander Kübler, Urs Müller‑Richter View Abstract ❯

Lithium chloride has a biphasic effect on prostate cancer stem cells and a proportional effect on midkine levels Mine Erguven, Gulperi Oktem, Ali Kara, Ayhan Bilir View Abstract ❯

Identification of candidate target genes of genomic aberrations in esophageal squamous cell carcinoma Tian‑Yun Shen, Li‑Li Mei, Yun‑Tan Qiu, Zhi‑Zhou Shi View Abstract ❯

Comparable roles of CD44v8‑10 and CD44s in the development of bone metastases in a mouse model Toru Hiraga, Hiroaki Nakamura View Abstract ❯

RANKL: A promising circulating marker for bone metastasis response Toni Ibrahim, Marianna Ricci, Emanuela Scarpi, Alberto Bongiovanni, Rossana Ricci, Nada Riva, Chiara Liverani, Alessandro De Vita, Federico La Manna, Devil Oboldi, Patrizia Serra, Flavia Foca, Lorenzo Cecconetto, Dino Amadori, Laura MercatalI View Abstract ❯

Programmed cell death 4 and BCR‑ABL fusion gene expression are negatively correlated in chronic myeloid leukemia Xia Zhang, Riming Liu, Baohua Huang, Xiaolu Zhang, Weijuan Yu, Cuixia Bao, Jie Li, Chengming Sun View Abstract ❯

Overlap of the cancer genome atlas and the immune epitope database Shaimaa Sait, Timothy Fawcett, George Blanck View Abstract ❯

Effects of Hedera helix L. extracts on rat prostate cancer cell proliferation and motility Hatice Gumushan‑Aktas, Seyhan Altun View Abstract ❯

miRNA regulation of Sirtuin‑1 expression in human astrocytoma Sara Romeo, Alfredo Conti, Francesca Polito, Chiara Tomasello, Valeria Barresi, Domenico La Torre, Maria Cucinotta, Flavio Angileri, Marcello Bartolotta, Rosa Di Giorgio, M'Hammed Aguennouz View Abstract ❯

TGFB2 and BCL2L11 methylation in male laryngeal cancer patients Zhisen Shen, Xiaoying Chen, Qun Li, Huadan Ye, Jinyun Li, Chongchang Zhou, Shiwei Duan View Abstract ❯

Quantitative detection of TUSC3 promoter methylation - a potential biomarker for prognosis in lung cancer Uta Duppel, Matthias Woenckhaus, Christian Schulz, Johannes Merk, Wolfgang Dietmaier View Abstract ❯

MMP-14 and TGFβ-1 methylation in pituitary adenomas Kornelija Ruskyte, Rasa Liutkevicienė, Alvita Vilkeviciute, Paulina Vaitkiene, Indre Valiulytė, Brigita Glebauskiene, Loresa Kriauciuniene, Dalia Zaliuniene View Abstract ❯

Atypical presentation of a gastric stromal tumor masquerading as a giant intraabdominal cyst: A case report Ke‑Kang Sun, Song Xu, Jinzhen Chen, Gang Liu, Xiaojun Shen, Xiaoyang Wu View Abstract ❯

miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells Fang Zheng, Jiahe Zhang, Siyu Luo, Jing Yi, Ping Wang, Quanqing Zheng, Yurong Wen View Abstract ❯

6-8 October, 2016, Metropolitan Hotel, Athens, Greece 21st World Congress on Advances in Oncology & 19th International Symposium on Molecular Medicine

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Roles of 5-HT1A receptor in the expression of AMPA receptor and BDNF in developing mouse cortical neurons

Publication date: Available online 1 October 2016
Source:Neuroscience Research
Author(s): Yuko Yoshimura, Chihiro Ishikawa, Haruki Kasegai, Tomoyuki Masuda, Masaaki Yoshikawa, Takashi Shiga
The possible interactions between serotonergic and glutamatergic systems during neural development and under the pathogenesis of depression remain unclear. We now investigated roles of 5-HT1A receptor in the mRNA expression of AMPA receptor subunits (GluR1 and GluR2) and brain-derived neurotrophic factor (BDNF) using primary culture of cerebral cortex of mouse embryos. Neurons at embryonic day 18 were cultured for 3days or 14days and then treated with 5-HT1A receptor agonist (8-OH-DPAT) for 3hours or 24hours. In neurons cultured for 3 days, 8-OH-DPAT treatment for both 3hours and 24hours increased the mRNA levels of BDNF and GluR1, but not GluR2. In neurons cultured for 14 days, however, 8-OH-DPAT had no effects on these mRNA levels. Next, we examined in vivo roles of 5-HT1A receptor by administration of 8-OH-DPAT to newborn mice. Twenty-four hours after the oral administration of 8-OH-DPAT, the mRNA expression of BDNF was decreased in the frontal cortex, but had no effects on the mRNA expression of GluR1 and GluR2. Taken together, the present study suggests that 5-HT1A receptor activation modulates mRNA expression of AMPA receptor subunit and BDNF in cortical neurons, and the effects are different between in vitro and in vivo.



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Targetingfibroblast growth factorreceptors and Immune checkpoint inhibitors for the treatment of advanced bladder Cancer: New direction and New Hope

Publication date: Available online 1 October 2016
Source:Cancer Treatment Reviews
Author(s): Rafael Morales-Barrera, Cristina Suárez, Ana Martínez de Castro, Fabricio Racca, Claudia Valverde, Xavier Maldonado, Juan Maria Bastaros, Juan Morote, Joan Carles
Bladder cancer is one of the leading causes of death in Europe and the United States. About 25% of patients with bladder cancer have advanced disease (muscle-invasive or metastatic disease) at presentation and are candidates for systemic chemotherapy. In the setting of metastatic disease, use of cisplatin-based regimens improves survival. However, despite initial high response rates, the responses are typically not durable leading to recurrence and death in the vast majority of these patients with median overall survival of 15 months and a 5-year survival rate of ⩽ 10%. Furthermore, unfit patients for cisplatin have no standard of care for first line therapy in advance disease Most second-line chemotherapeutic agents tested have been disappointing. Newer targeted drugs and immunotherapies are being studied in the metastatic setting, their usefulness in the neoadjuvant and adjuvant settings is also an intriguing area of ongoing research. Thus, new treatment strategies are clearly needed. The comprehensive evaluation of multiple molecular pathways characterized by The Cancer Genome Atlas project has shed light on potential therapeutic targets for bladder urothelial carcinomas.We have focused especially on emerging therapies in locally advanced and metastatic urothelial carcinoma with an emphasis on immune checkpoints inhibitors and FGFR targeted therapies, which have shown great promise in early clinical studies



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Out of hours workload management: Bayesian inference for decision support in secondary care

Publication date: Available online 1 October 2016
Source:Artificial Intelligence in Medicine
Author(s): Iker Perez, Michael Brown, James Pinchin, Sarah Martindale, Sarah Sharples, Dominick Shaw, John Blakey
ObjectiveIn this paper, we aim to evaluate the use of electronic technologies in Out of Hours (OoH) task-management for assisting the design of effective support systems in health care; targeting local facilities, wards or specific working groups. In addition, we seek to draw and validate conclusions with relevance to a frequently revised service, subject to increasing pressures.Methods and MaterialWe have analysed 4 years of digitised demand-data extracted from a recently deployed electronic task-management system, within the Hospital at Night setting in two jointly coordinated hospitals in the United Kingdom. The methodology employed relies on Bayesian inference methods and parameter-driven state-space models for multivariate series of count data.ResultsMain results support claims relating to (i) the importance of data-driven staffing alternatives and (ii) demand forecasts serving as a basis to intelligent scheduling within working groups. We have displayed a split in workload patterns across groups of medical and surgical specialities, and sustained assertions regarding staff behaviour and work-need changes according to shifts or days of the week. Also, we have provided evidence regarding the relevance of day-to-day planning and prioritisation.ConclusionsThe work exhibits potential contributions of electronic tasking alternatives for the purpose of data-driven support systems design; for scheduling, prioritisation and management of care delivery. Electronic tasking technologies provide means to design intelligent systems specific to a ward, speciality or task-type; hence, the paper emphasizes the importance of replacing traditional pager-based approaches to management for modern alternatives.



http://ift.tt/2dn9EK0

Habitats of ancient hunter-gatherers in the Puna: Resilience and discontinuities during the Holocene

Publication date: Available online 1 October 2016
Source:Journal of Anthropological Archaeology
Author(s): Hugo D. Yacobaccio, Marcelo R. Morales, Rodolphe Hoguin
Hunting groups are closely linked to the environments in which they live, especially in the deserts. This paper explores the relationship between people and desert environments in the long term using key concepts such as resilience, refugia and habitat loss. A thorough paleoenvironmental analysis was conducted to improve our understanding about continuities and discontinuities in the archaeological record of the South Andean highlands. This allowed us to test ideas about the availability of adequate human habitats during the Holocene. Cultural archives such as archaeofauna and lithic technology are employed to illustrate and discuss methodological perspectives for the identification and description of resilient human habitats in arid landscapes in the South Andean Puna.



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Impact of R264C and R264H polymorphisms in human aromatase function

Publication date: Available online 1 October 2016
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Roberta Baravalle, Giovanna Di Nardo, Andrea Bandino, Ines Barone, Stefania Catalano, Sebastiano Andò, Gianfranco Gilardi
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. The human enzyme is highly polymorphic and literature data correlate aromatase single nucleotide polymorphisms to the onset of pathologies such as breast cancer and neurodegenerative diseases. The aims of this study were i) to study the influence of the mutations R264C and R264H on the structure-function of the enzyme also upon phospohorylation by selected kinases and ii) to compare the activity of the variants to that of aromatase wild type in two different cell lines.Far-UV circular dichroism spectroscopy, thermal denaturation experiments and CO-binding assay showed that the two polymorphic variants are correctly folded. Steady-state kinetics experiments showed that rArom R264C and R264H exhibit a 1.5 and 3.4 folds lower catalytic efficiency, respectively, when compared to the wild type protein.Since R264 is part of the consensus motif of PKA and PKG1, phosphorylation experiments were performed to study the effect on aromatase function. Phosphorylation by PKA caused a decrease in activity by 36.2%, 49.3% and 27.9% in the wild type, R264C and R264H proteins respectively. Phosphorylation by PKG1 was also found to decrease the activity by 30.3%, 30.5% and 15.4% in the wild type, R264C and R264H proteins respectively.Experiments performed on the three full-length proteins expressed in human MCF-7 breast cancer cells and rat ST14A neuronal cells showed that, depending on the cell line used, the activity of the proteins is different, implicating different cellular mechanisms modulating aromatase activity.This work demonstrate that R264 polymorphism causes an intrinsic alteration of aromatase activity together with a different consensus for phosphorylation by different kinases, indicating that estrogen production can be different when such mutations are present.These findings are significant in understanding the onset and treatment of pathologies in which aromatase has been shown to be involved.

Graphical abstract

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Leucite and cooling rate effect on porcelain–zirconia mechanical behavior

Publication date: Available online 1 October 2016
Source:Dental Materials
Author(s): P.D. Meirelles, Y.O. Spigolon, M. Borba, P. Benetti
ObjectiveThis study investigated the influence of the cooling protocol on the mechanical behavior of Y-TZP veneered with porcelain with different compositions. The tested hypotheses were: (1) Y-TZP infrastructures veneered with porcelain containing leucite in its composition presents higher flexural strength (σ) and reliability (m), and (2) slow cooling protocol results in greater σ and m.MethodsA total of 120 bilayer porcelain-Y-TZP bar-shaped specimens were prepared with the dimensions of 1.8mm (0.8mm Y-TZP±1.0mm porcelain)×4.0mm×16.0mm. Specimens were divided into four groups (n=30) according to the porcelain composition (containing or not leucite) and cooling protocol. Fast cooling was performed by opening the furnace chamber at sintering temperature. For the slow cooling, the chamber was maintained closed until it reached the room temperature. Specimens were tested in three-point bending with the porcelain surface under tension using a universal testing machine, in 37°C water, at 0.5mm/min crosshead speed. Data were analyzed by two-way ANOVA, Tukey post-hoc test (α=0.05) and Weibull.ResultsY-TZP veneered with porcelains with different microstructural composition presented similar σ and m values (p=0.718). The cooling protocol had no influence on the σ and m values of the experimental groups (p=0.718). Cracking represented 95% of failures, whereas the initial flaw propagated from the porcelain surface towards the interface.SignificanceY-TZP veneered with porcelain containing or not leucite present similar mechanical behavior and, at 1-mm thickness, is not sensitive to the cooling protocol.



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Reducing the effect of polymerization shrinkage of temporary fixed dental prostheses by using different materials and fabrication techniques

Publication date: Available online 1 October 2016
Source:Dental Materials
Author(s): Wojtek Libecki, Adham Elsayed, Sandra Freitag-Wolf, Matthias Kern
ObjectiveThe aim of this laboratory study was to evaluate the horizontal and vertical effects of the polymerization shrinkage of three-unit temporary fixed dental prostheses (FDPs) on the position of the prepared teeth. In addition, the reduction of these effects by using different fabrication techniques was evaluated.MethodsA total of 192 temporary FDPs were fabricated using one methacrylate (MA) and two dimethacrylate (DMA) materials. Each material group (n=64) was divided into two groups according to the fabrication methods (M1: curing on the prepared teeth, M2: curing in a silicone mold). Each fabrication group was divided into four subgroups (n=8) according to the relining method used (B: no relining, S: spacer foil 300μm, DG: grinding-out with 500μm cutting depth, and FG: free grinding). The experimental apparatus consisted of two abutment teeth lowered at right angles into a silicone mold. One prepared tooth was embedded in silicone to simulate the periodontium and permit slight horizontal tooth movement. The dimensional changes were recorded with an optical microscope. The test images were superimposed and measured using image analysis software.ResultsThe statistical analysis showed that there were significantly higher horizontal changes for the MA than the DMA resins in M1, while there was none in M2. Regarding the vertical changes, there were significant differences between the baseline group and all relining and fabrication groups in all materials.SignificanceRelining of directly fabricated temporary FDPs significantly reduces the effect of polymerization shrinkage and thus secures the position of the prepared teeth.



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Scholar : These new articles for Annals of the American Association of Geographers are available online

The online platform for Taylor & Francis Online content New for Annals of the American Association of Geographers and online now on Taylor & Francis Online: Methods, Models, and GIS Sexual Orientation, Gender, and Environmental Injustice: Unequal Carcinogenic Air Pollution Risks in Greater Houston Timothy W. Collins, Sara E. Grineski & Danielle X. Morales Pages: 1-21 | DOI: 10.1080/24694452.2016.1218270 Inequality in Beijing: A Spatial Multilevel Analysis of Perceived Environmental Hazard and Self-Rated Health | Jing Ma, Gordon Mitchell, Guanpeng Dong & Wenzhong Zhang Pages: 1-21 | DOI: 10.1080/24694452.2016.1224636 Nature and Society A Human Right to Science?: Precarious Labor and Basic Rights in Science and Bioprospecting Benjamin D. Neimark & Saskia Vermeylen Pages: 1-16 | DOI: 10.1080/24694452.2016.1218749 Analyzing Entrepreneurial Social Networks with Big Data Feng Wang, Elizabeth A. Mack & Ross Maciewjewski Pages: 1-21 | DOI: 10.1080/24694452.2016.1222263 Hidden Abodes: Industrializing Political Ecology Matthew T. Huber Pages: 1-16 | DOI: 10.1080/24694452.2016.1219249 Have you seen the SRHE's new journal? Policy Reviews in Higher Education is now looking for submissions, click here to find out more and submit your paper. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.