Scholar : Ειδοποίηση Μελετητή - [ ΦΩΝΗ ]

Ειδοποίηση Μελετητή:[ ΦΩΝΗ ]

Translated with Text and Commentary

EH Campbell - 2017

... sing. of παῖς. 15 Att., Ep., or Ion., fem. acc. sing. of φωνή. 16 masc. gen. sing. aor. act. ... part. of
φυράω, to mix flour or meal so as to make it into dough; to knead. 87 Att., Ep., or Ion., fem. acc.
sing. of φωνή, produce a sound. 88 Att., Ep., or Ion., masc. acc. sing. of ἐραστής, lover. ...

[PDF] EMPEDOCLES'ON NATURE FRR. B 8–9 IN THE CONTEXT OF PLUTARCH'S AGAINST COLOTES

R Janko - The Classical Quarterly, 2017

... EB 16 B. Inwood (The Poem of Empedocles [Toronto, 20012], 95–6), in his translation of
1113A–D, thinks this φωνή is γένεσις, referring back to 1113A, where Plutarch notes parenthetically
that most people personify Birth and Death in cases where things are constituted and ...

[PDF] Μελέτη, έλεγχος και αξιολόγηση ασφάλειας υλοποιήσεων δικτύων καθοριζόμενων από λογισμικό

Δ Βαρτζώκα - 2017

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΜΑΚΕΔΟΝΙΑΣ ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ ΤΜΗΜΑΤΟΣ
ΕΦΑΡΜΟΣΜΕΝΗΣ ΠΛΗΡΟΦΟΡΙΚΗΣ ΜΕΛΕΤΗ, ΕΛΕΓΧΟΣ ΚΑΙ ΑΞΙΟΛΟΓΗΣΗ ΑΣΦΑΛΕΙΑΣ
ΥΛΟΠΟΙΗΣΕΩΝ ΔΙΚΤΥΩΝ ΚΑΘΟΡΙΖΟΜΕΝΩΝ ΑΠΟ ΛΟΓΙΣΜΙΚΟ Διπλωματική Εργασία ...

[PDF] Μελέτη του τρόπου διδασκαλίας και απόκτησης της αγγλικής γλώσσας από μαθητές με δυσλεξία

Σ Ντούκα - 2017

Page 1. ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ ΤΜΗΜΑΤΟΣ ΕΚΠΑΙΔΕΥΤΙΚΗΣ ΚΑΙ
ΚΟΙΝΩΝΙΚΗΣ ΠΟΛΙΤΙΚΗΣ ΚΑΤΕΥΘΥΝΣΗ ΕΙΔΙΚΗΣ ΑΓΩΓΗΣ Διπλωματική Εργασία με Τίτλο:
«Μελέτη του Τρόπου Διδασκαλίας και Απόκτησης της Αγγλικής Γλώσσας από ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ Decannulat

Ειδοποίηση Μελετητή:[ Decannulation ]

The Efficacy and Safety of the Flexible Fiber CO2 Laser Delivery System in the Endoscopic Management of Pediatric Airway Problems: Our Long Term Experience

GS Lee, A Irace, R Rahbar - International Journal of Pediatric Otorhinolaryngology, 2017

... 12]. In comparison to microsuspension laryngoscopy with an articulated arm, the
fiberoptic CO2 laser carrier resulted in significantly fewer additional procedures and
more cases of immediate postoperative decannulation. The ...

[HTML] FIND ISSUES

GWY Ng, HJ Yuen, KC Sin, AKH Leung, KWA Yeung… - Hong Kong Med J, 2017

... Decannulation can be considered if the patient is stable for >1 hour following the
adjustment.43. The ECMO cannulae are removed after heparin infusion has been
stopped for more than 60 minutes, and there is no major coagulopathy. ...

根因分析法在老年痴呆患者非计划拔管管理中的应用

章洁， 陈向荣， 林静， 张艳， 马容莉

... Methods The adverse events of 70 patients with na-sogastric tube unplanned extubation nursing
of RCA were analyzed to determine the causes of unplanned extubation -and corresponding
measures were put forward .The nasogastric tube unplanned decannulation rate of ...

Case Studies in Adult Intensive Care Medicine

D Bryden, A Temple - 2017

Plasma exchange for the patients with dilated cardiomyopathy in children is safe and effective in improving both cardiac function and daily activities

T Moriguchi, K Koizumi, K Matsuda, N Harii, J Goto… - Journal of Artificial Organs

... to return to general ward. Patient no. 6 needed VA ECMO support to maintain a blood
circulation before the treatment of PE. After a course of PE, the patient survived to
ECMO decannulation. These experiences show PE to be ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ ΡΙΝΙΚ

Ειδοποίηση Μελετητή:[ ΡΙΝΙΚΟ ΔΙΑΦΡΑΓΜΑ ]

[PDF] MEMORIA HISTÓRICA DE PLASENCIA

Y LAS COMARCAS

... Ante esta situación, el joven Alfonso VIII solicitó la ayuda de todos los reinos cristianos
en Santa Cruzada, mandando un visado al Papa Inocencio, y que repercutió en la definitiva
expulsión almohade de la Península tras la Batalla de Tolosa. ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ ΟΓΚΟΛ

Ειδοποίηση Μελετητή:[ ΟΓΚΟΛΟΓΙΑ ]

[PDF] Stem Cells in

ΞP Palace - 2017

... Παρασκευή 7 Απριλίου 2017 ΑΙΘΟΥΣΑ Β 8 Page 9. 7-8 Απριλίου 2017 Ξενοδοχείο Porto Palace
Θεσσαλονίκη 16.00 - 17.00 ΣΤΡΟΓΓΥΛΗ ΤΡΑΠΕΖΑ ΟΓΚΟΛΟΓΙΑ ΚΑΙ ΓΥΝΑΙΚΟΛΟΓΙΑ Προεδρείο:
Θ. Αγοραστός, Α. Παπανικολάου Βλαστοκύτταρα και καρκίνος ενδομητρίου Ι. ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ Πλαστ

Ειδοποίηση Μελετητή:[ Πλαστική Χειρουργική ]

[PDF] Stem Cells in

ΞP Palace - 2017

... Κύριος στόχος του συνεδρίου είναι η ενημέρωση της χειρουργικής κοινότητας για τις ... 17.00 - 18.00
ΣΤΡΟΓΓΥΛΗ ΤΡΑΠΕΖΑ ΒΛΑΣΤΟΚΥΤΤΑΡΑ ΣΤΗΝ ΠΛΑΣΤΙΚΗ ΧΕΙΡΟΥΡΓΙΚΗ Προεδρείο: Ε. ... Ο
ρόλος των βλαστοκυττάρων στην επανορθωτική χειρουργική: Έγκαυμα, τραύμα Γ. - Α. ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

The fight between a dwarf and a stork (Mosaic I century BC)

http://ift.tt/2poDZvU

Quality of life after thyroid surgery

Abstract

Purpose

The purpose of this study was to inquire how patients' quality of life is affected after thyroid surgery and the factors involved.

Methods

A semi-structured questionnaire and the World Health Organization Quality of Life Scale (WHOQOL-BREF) were applied to 101 patients prior to surgery. Thereafter data was collected in the early and again in the late post-operative period.

Results

Mean general health score for pre-operative quality of life was 6.72 ± 1.53 (3–10), mean physical field score was 22.81 ± 2.77 (17–31), mean psychological field score was 21.69 ± 2.78 (15–28), mean social field score was 11.10 ± 1.94 (5–15) and mean environmental field score was 27.86 ± 4.30 (18–39). In the early post-operative period, mean general health score was 7.05 ± 1.45 (4–10), mean physical field score was 22.84 ± 2.83 (14–29), mean psychological field score was 21.67 ± 2.32 (16–27), mean social field score was 10.89 ± 1.96 (5–15) and mean environmental field score was 28.56 ± 4.18 (18–40). In the late post-operative period, the general health score for quality of life was 7.43 ± 1.34 (4–10), mean physical field score was 23.59 ± 2.70 (17–35), mean psychological field score was 21.75 ± 2.34 (14–29), mean social field score was 11.23 ± 1.94 (6–15) and mean on-field environment score was 29.30 ± 3.96 (16–40). The pre-operative levels of symptoms were found to be higher than early and late post-operative periods.

Conclusions

Quality of life increased after total thyroidectomy and statistically significant improvement was observed in late post-operative stage.

http://ift.tt/2nW9lJ6

Validation of the Italian Quality of Life in Short Stature Youth (QoLISSY) questionnaire

Abstract

Purpose

The Quality of Life in Short Stature Youth (QoLISSY) questionnaire is a disease-specific instrument developed to assess health-related quality of life (HrQoL) in children with short stature. While the original instrument was simultaneously developed in five European countries, this study describes the results of the Italian QoLISSY translation, cultural adaptation, and validation.

Methods

Focus group discussions and a cognitive debriefing process with children (N = 12) diagnosed with growth hormone deficiency or idiopathic short stature and one parent each, as well as parents of younger children (N = 20) were conducted to examine the linguistic and content validity of the Italian version. Psychometric testing was performed using data from the subsequent field- and re-test (N = 32).

Results

The results of the qualitative testing of the Italian sample revealed comparability of content to data of the original five European countries. The following field- and re-test results were psychometrically satisfactory including good item and scale operating characteristics, sufficient evidence of reliability, and acceptable evidence of construct validity.

Conclusion

In conclusion, the Italian QoLISSY HrQoL-dimensions are comparable to other European countries. The psychometric quality of the Italian QoLISSY version is satisfactory and the instrument is ready for use in Italian patients and their parents.

http://ift.tt/2oYZTta

Scholar : These new articles for Research in Drama Education: The Journal of Applied Theatre and Performance are available online

The online platform for Taylor & Francis Online content New for Research in Drama Education: The Journal of Applied Theatre and Performance and online now on Taylor & Francis Online: Original Articles 'Where the wild things are' – an insider's experience of the contemporary drama classroom Anon Pages: 1-4 | DOI: 10.1080/13569783.2017.1293511 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Anti-tubercular drug discovery: in silico implications and challenges

Publication date: 15 June 2017
Source:European Journal of Pharmaceutical Sciences, Volume 104
Author(s): Rukmankesh Mehra, Inshad Ali Khan, Amit Nargotra
Tuberculosis (TB) has been reported as a major public health concern, especially in the developing countries. WHO report on tuberculosis 2016 shows a high mortality rate caused by TB leading to 1.8 million deaths worldwide (including deaths due to TB in HIV positive individuals), which is one of the top 10 causes of mortality in 2015. However, the main therapy used for the treatment of TB is still the Direct Observed Therapy Short-course (DOTS) that consists of four main first-line drugs. Due to the prolonged and unorganized use of these drugs, Mycobacterium tuberculosis (Mtb) has developed drug-resistance against them. To overcome this drug-resistance, efforts are continuously being made to develop new therapeutics. New drug-targets of Mtb are pursued by the researchers to develop their inhibitors. For this, new methodologies that comprise of the computational drug designing techniques are vigorously applied. A major limitation that is found with these techniques is the inability of the newly identified target-based inhibitors to inhibit the whole cell bacteria. A foremost factor for this limitation is the inability of these inhibitors to penetrate the bacterial cell wall. In this regard, various strategies to overcome this limitation have been discussed in detail in this review, along with new targets and new methodologies. A bunch of in silico tools available for the prediction of physicochemical properties that need to be explored to deal with the permeability issue of the Mtb inhibitors has also been discussed.

Graphical abstract

http://ift.tt/2omPV3G

Transparent ciprofloxacin-povidone antibiotic films and nanofiber mats as potential skin and wound care dressings

Publication date: 15 June 2017
Source:European Journal of Pharmaceutical Sciences, Volume 104
Author(s): Marco Contardi, José A. Heredia-Guerrero, Giovanni Perotto, Paola Valentini, Pier Paolo Pompa, Raffaele Spanò, Luca Goldoni, Rosaria Bertorelli, Athanassia Athanassiou, Ilker S. Bayer
Water insoluble monohydrochloride monohydrate free ciprofloxacin (Cipro) antibiotic was incorporated in polyvinylpyrrolidone (PVP) polymer matrix by using acetic acid co-solvent in water. The resultant solutions were cast into fully transparent antimicrobial films. Proper concentrations of acetic acid eliminated in situ crystallization of the antibiotic and the resultant phase separation upon solvent evaporation. The solutions could also be electrospun into nanofiber mats (non-transparent). Presence of residual PVP-bound acetic acid in dry PVP films induced unprecedented levels of plasticity (stretching capacity) and softness to the films. Additionally, PVP-bound acetic acid also acted as an antiseptic. Antibacterial properties of the films and fiber mats were confirmed on Escherichia coli and Bacillus subtilis (growth and viability). Films and nanofiber mats demonstrated promising wound resorption characteristics by using in vivo full-thickness excisional skin wound healing mice model. Nanofiber mats were resorbed much faster than transparent films. Wound exudate absorption in the films and resorption rate of the nanofiber mats were dependent on the starting acetic acid concentrations. The fact that PVP/Cipro solutions in aqueous acetic acid can be used either to produce transparent soft films or nanofiber mats renders this process highly suitable for the fabrication of new-generation potential dressings for wound management and care.

Graphical abstract

http://ift.tt/2omNz4B

Design and in vivo evaluation of solid lipid nanoparticulate systems of Olanzapine for acute phase schizophrenia treatment: Investigations on antipsychotic potential and adverse effects

Publication date: Available online 11 April 2017
Source:European Journal of Pharmaceutical Sciences
Author(s): Emil Joseph, Satish Reddi, Vibhu Rinwa, Garima Balwani, Ranendra Saha
The present paper discusses the design, characterization and in vivo evaluation of glyceryl monostearate nanoparticles of Olanzapine, an atypical antipsychotic drug for acute schizophrenia treatment, during which hospitalization is mandatory and adverse effects are at its peak. The solid lipid nanoparticulate system was obtained by emulsification-ultra sonication technique wherein three factors such as solid lipid content, concentration of surfactant and drug: solid lipid ratio were selected at three different levels in order to study their influence on significant characteristic responses such as particle size, encapsulation efficiency and drug content.A Box Behnken design with 17 runs involving whole factors at three levels was employed for the study. The optimized formulation was further coated with Polysorbate 80 in order to enhance its brain targeting potential through endocytosis transport process via blood brain barrier. The designed formulations were pre-clinically tested successfully in Wistar rat model for in vivo antipsychotic efficacy (apomorphine induced psychosis) and adverse effects (weight gain study for 28days).The results obtained indicated that solid lipid nanoparticles had very narrow size distribution (151.29±3.36nm) with very high encapsulation efficiency (74.51±1.75%). Morphological studies by SEM have shown that solid lipid nanoparticles were spherical in shape with smooth surface. Olanzapine-loaded nanoparticles prepared from solid lipid, extended the release of drug for 48h, as found by the in vitro release studies. The formulations also exhibited high redispersibility after freeze-drying and stability study results demonstrated good stability, with no significant change for a period of 6months. In vivo evaluation and adverse effects studies of Olanzapine-loaded nanoparticulate systems in animal model have demonstrated an improved therapeutic efficacy than pure Olanzapine. The antipsychotic effect of drug loaded nanoparticulate systems was maintained for 48h as compared to 8h antipsychotic action of pure Olanzapine solution. The weight gain studies for 28days demonstrated a significant inhibition in weight gain for Olanzapine-loaded nanoparticulate systems as compared to the pure Olanzapine. The present research findings indicate that OLN-loaded nanoparticulate systems may be highly promising for effective delivery of Olanzapine with better efficacy and minimum adverse effects.

Graphical abstract

http://ift.tt/2omznJc

Covalent inhibitors of LgtC: a blueprint for the discovery of non-substrate-like inhibitors for bacterial glycosyltransferases

Publication date: Available online 11 April 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Yong Xu, Ruth Smith, Mirella Vivoli, Masaki Ema, Niina Goos, Sebastian Gehrke, Nicholas J. Harmer, Gerd K. Wagner
Non-substrate-like inhibitors of glycosyltransferases are sought after as chemical tools and potential lead compounds for medicinal chemistry, chemical biology and drug discovery. Here, we describe the discovery of a novel small molecular inhibitor chemotype for LgtC, a retaining α-1,4-galactosyltransferase involved in bacterial lipooligosaccharide biosynthesis. The new inhibitors, which are structurally unrelated to both the donor and acceptor of LgtC, have low micromolar inhibitory activity, comparable to the best substrate-based inhibitors. We provide experimental evidence that these inhibitors react covalently with LgtC. Results from detailed enzymological experiments with wild-type and mutant LgtC suggest the non-catalytic active site residue Cys246 as a likely target residue for these inhibitors. Analysis of available sequence and structural data reveals that non-catalytic cysteines are a common motif in the active site of many bacterial glycosyltransferases. Our results can therefore serve as a blueprint for the rational design of non-substrate-like, covalent inhibitors against a broad range of other bacterial glycosyltransferases.

Graphical abstract

http://ift.tt/2poJef5

Short Takes

Publication date: Available online 10 April 2017
Source:Pediatric Neurology
Author(s): Steven G. Pavlakis




http://ift.tt/2ouBVW7

Short Takes

Publication date: Available online 10 April 2017
Source:Pediatric Neurology
Author(s): Steven G. Pavlakis




http://ift.tt/2olWKkn

A wind-tunnel study of the effect of turbulence on PM10 deposition onto vegetation

Publication date: June 2017
Source:Atmospheric Environment, Volume 159
Author(s): Timothy A. Price, Rob Stoll, John M. Veranth, Eric R. Pardyjak
The fraction of particles deposited from an airstream (deposition fraction) onto idealized substrates has been shown to be influenced by isotropic turbulence through increased deposition onto nonimpaction surfaces (Moran, S.M., Pardyjak, E.R., Veranth, J.M., 2013. Understanding the role of grid turbulence in enhancing PM10 deposition: scaling the Stokes number with Rλ. Physics of Fluids 25, 115103). Here, we extend this by considering deposition onto realistic vegetative surfaces. Results from wind-tunnel deposition experiments conducted using nonvolatile particles and various types of artificial vegetation under grid-generated isotropic turbulence conditions are presented and compared with the previous idealized experiments. The nonimpaction-surface fraction of the total deposition is shown to scale with the Reynolds number and a new effective area parameterization is developed to account for inertial deposition onto nonimpaction surfaces. A combined formulation of the turbulent Stokes number and the effective deposition area are used to collapse the data. The results show that laminar impaction models dramatically under predict deposition for a given classical Stokes number. The new parameterization shows improved performance for deposition onto vegetation with the coefficient of determination (r2) increasing from 0.15 to 0.65 when accounting for turbulence and nonimpaction-surface deposition area.



http://ift.tt/2olSa5v

Estimating relative contributions of primary and secondary sources of ambient nitrated and oxygenated polycyclic aromatic hydrocarbons

Publication date: June 2017
Source:Atmospheric Environment, Volume 159
Author(s): Shaojie Zhuo, Wei Du, Guofeng Shen, Bengang Li, Junfeng Liu, Hefa Cheng, Baoshan Xing, Shu Tao
Polycyclic aromatic hydrocarbons (PAHs) derivatives like nitrated and oxygenated PAHs (nitro- and oxy-PAHs) are of growing interests due to their direct and potentially high toxic properties. PAHs derivatives can be produced from primary sources and also can derive from photochemical reactions, however, works about the quantitative contributions of primary and secondary sources are scarce. In this study, levels and seasonal distributions of ambient nitro- and oxy-PAHs were studied in a megacity Nanjing located in East China and evaluated for relative contributions of different sources. The annual average concentrations of most PAH derivatives were generally lower than the levels found in north China, but higher than the levels reported for south China. The relative contributions of secondary formation ranged from 10% to 47% for nitro-PAHs and ∼60% for oxy-PAHs. The study suggested that typical source apportionment technologies could be adopted to investigate primary and secondary sources of PAHs derivatives when derivatives are simultaneously measured with parent PAHs and other source markers. Future studies are interesting to develop, evaluate and compare different source apportionment methodologies for PAHs derivatives.

Graphical abstract

http://ift.tt/2ouyU8f

Improving technology through the coffee ring effect

Publication date: Available online 10 April 2017
Source:Materials Today
Author(s): David Bradley




http://ift.tt/2oTMzGD

Novel Method for Vessel Cross-Sectional Shear Wave Imaging

Publication date: Available online 10 April 2017
Source:Ultrasound in Medicine & Biology
Author(s): Qiong He, Guo-Yang Li, Fu-Feng Lee, Qihao Zhang, Yanping Cao, Jianwen Luo
Many studies have investigated the applications of shear wave imaging (SWI) to vascular elastography, mainly on the longitudinal section of vessels. It is important to investigate SWI in the arterial cross section when evaluating anisotropy of the vessel wall or complete plaque composition. Here, we proposed a novel method based on the coordinate transformation and directional filter in the polar coordinate system to achieve vessel cross-sectional shear wave imaging. In particular, ultrasound radiofrequency data were transformed from the Cartesian to the polar coordinate system; the radial displacements were then estimated directly. Directional filtering was performed along the circumferential direction to filter out the reflected waves. The feasibility of the proposed vessel cross-sectional shear wave imaging method was investigated through phantom experiments and ex vivo and in vivo studies. Our results indicated that the dispersion relation of the shear wave (i.e., the guided circumferential wave) within the vessel can be measured via the present method, and the elastic modulus of the vessel can be determined.



http://ift.tt/2omUwCX

Predicting Tissue Susceptibility to Mechanical Cavitation Damage in Therapeutic Ultrasound

Publication date: Available online 10 April 2017
Source:Ultrasound in Medicine & Biology
Author(s): Lauren Mancia, Eli Vlaisavljevich, Zhen Xu, Eric Johnsen
Histotripsy is a developing focused ultrasound procedure that uses cavitation bubbles to mechanically homogenize soft tissue. To better understand the mechanics of tissue damage, a numerical model of single-bubble dynamics was used to calculate stress, strain and strain rate fields produced by a cavitation bubble exposed to a tensile histotripsy pulse. The explosive bubble growth and its subsequent collapse were found to depend on the properties of the surrounding material and on the histotripsy pulse. Stresses far greater than gigapascals were observed close to the bubble wall, but attenuated by four to six orders of magnitude within 50 μm from the bubble wall, with at least two orders of magnitude attenuation occurring within the first 10 μm from the bubble. Elastic stresses were found to dominate close to the bubble wall, whereas viscous stresses tended to persist farther into the surroundings. A non-dimensional parameter combining tissue, waveform and bubble properties was identified that dictates the dominant stress (viscous vs. elastic) as a function of distance from the bubble nucleus. In a cycle of bubble growth and collapse, characteristic times at which mechanical damage is likely to occur and dominant mechanisms acting at each time were identified.



http://ift.tt/2o2MD2Z

The application of illite supported nanoscale zero valent iron for the treatment of uranium contaminated groundwater

Publication date: September 2017
Source:Journal of Environmental Radioactivity, Volumes 175–176
Author(s): C. Jing, S. Landsberger, Y.L. Li
In this study, nanoscale zero valent iron I-NZVI was investigated as a remediation strategy for uranium contaminated groundwater from the former Cimarron Fuel Fabrication Site in Oklahoma, USA. The 1 L batch-treatment system was applied in the study. The result shows that 99.9% of uranium in groundwater was removed by I-NZVI within 2 h. Uranium concentration in the groundwater stayed around 27 μg/L, and there was no sign of uranium release into groundwater after seven days of reaction time. Meanwhile the release of iron was significantly decreased compared to NZVI which can reduce the treatment impact on the water environment. To study the influence of background pH of the treatment system on removal efficiency of uranium, the groundwater was adjusted from pH 2–10 before the addition of I-NZVI. The pH of the groundwater was from 2.1 to 10.7 after treatment. The removal efficiency of uranium achieved a maximum in neutral pH of groundwater. The desorption of uranium on the residual solid phase after treatment was investigated in order to discuss the stability of uranium on residual solids. After 2 h of leaching, 0.07% of the total uranium on residual solid phase was leached out in a HNO3 leaching solution with a pH of 4.03. The concentration of uranium in the acid leachate was under 3.2 μg/L which is below the EPA's maximum contaminant level of 30 μg/L. Otherwise, the concentration of uranium was negligible in distilled water leaching solution (pH = 6.44) and NaOH leaching solution (pH = 8.52). A desorption study shows that an acceptable amount of uranium on the residuals can be released into water system under strong acid conditions in short terms. For long term disposal management of the residual solids, the leachate needs to be monitored and treated before discharge into a hazardous landfill or the water system. For the first time, I-NZVI was applied for the treatment of uranium contaminated groundwater. These results provide proof that I-NZVI has improved performance compared to NZVI and is a promising technology for the restoration of complex uranium contaminated water resources.



http://ift.tt/2olTTrF

Multifocal visual evoked potentials in optic neuritis and multiple sclerosis: A review

Publication date: Available online 11 April 2017
Source:Clinical Neurophysiology
Author(s): Gorm Pihl-Jensen, Mathias Falck Schmidt, Jette Lautrup Frederiksen
Multifocal visual evoked potential (mf-VEP) represents a new approach to the classical full field (ff-)VEP with separate responses from up to 60 sectors of the visual field. A thorough literature survey of the use of mf-VEP in optic neuritis (ON) and multiple sclerosis (MS) is presented (38 published studies were retrieved). Mf-VEP provides direct topographical information of specific lesions and facilitates investigations on structural-functional correlations thus providing new methods for exploring the interplay between demyelination, atrophy and remyelination in MS. Good correlation was shown between mf-VEP and OCT, ff-VEP, MRI (MTR, DTI), 30-2 standard automated perimetry and low-contrast-visual acuity. All but one study showed superior sensitivity and specificity compared to ff-VEP, especially with regards to small, peripheral lesions or lesions of the upper visual field. Mf-VEP has shown superior sensitivity and specificity than established methods in diagnosing optic nerve lesions and tracking functional recovery following lesions. Abnormal mf-VEP responses in the fellow, non-ON afflicted eye may predict MS risk in ON patients. No standardization currently exists and no direct comparisons in ON and MS between at least 5 different commercially available mf-VEP systems have so far been published. Despite these limitations, mf-VEP is a promising new tool of diagnostic and prognostic value of mf-VEP in ON and MS.



http://ift.tt/2o2Tbys

Applicability of NeuroTrend as a bedside monitor in the neuro ICU

Publication date: Available online 11 April 2017
Source:Clinical Neurophysiology
Author(s): J. Herta, J. Koren, F. Fürbass, A. Zöchmeister, M. Hartmann, A. Hosmann, C. Baumgartner, A. Gruber
ObjectiveTo assess whether ICU caregivers can correctly read and interpret continuous EEG (cEEG) data displayed with the computer algorithm NeuroTrend (NT) with the main attention on seizure detection and determination of sedation depth.Methods120 screenshots of NT (480 hours of cEEG) were rated by 18 briefly trained nurses and biomedical analysts. Multirater agreements (MRA) as well as interrater agreements (IRA) compared to a gold standard were calculated for items such as pattern type, pattern location, interruption of recording, seizure suspicion, consistency of frequency, seizure tendency and level of sedation.ResultsMRA as well as IRA were almost perfect (80-100%) for interruption of recording, spike-and-waves, rhythmic delta activity and burst suppression. A substantial agreement (60-80%) was found for electrographic seizure patterns, periodic discharges and seizure suspicion. Except for pattern localization (70.83-92.26%), items requiring a precondition and especially those who needed interpretation like consistency of frequency (47.47-79.15%) or level of sedation (41.10%) showed lower agreements.ConclusionsThe present study demonstrates that NT might be a useful bedside monitor in cases of subclinical seizures. Determination of correct sedation depth by ICU caregivers requires a more detailed training.SignificanceComputer algorithms may reduce the workload of cEEG analysis in ICU patients.



http://ift.tt/2omnVx8

Scholar : These new articles for Bulletin of Spanish Studies are available online

@media screen and (max-width:400px) { .two .column, .two .left, .two .right{ max-width: 100% !important; } } @media screen and (min-width: 401px) and (max-width:620px){ .two .column, .two .left, .two .right { max-width: 100% !important; } }

The online platform for Taylor & Francis Online content New for Bulletin of Spanish Studies and online now on Taylor & Francis Online: Original Articles Painting and Politics in El pintor de su deshonra: Monarchy As a Work of Art Grace M. Burton Pages: 1-26 | DOI: 10.1080/14753820.2017.1296671 A Note on the Circulation of Virgil's Eclogues in Renaissance Spain, 1496–1601 Alejandro Coroleu Pages: 1-12 | DOI: 10.1080/14753820.2017.1298299 El género pastoril y su parodia en las dos Arcadias de Lope de Vega: razones de una evolución Guillermo Serés Pages: 1-21 | DOI: 10.1080/14753820.2017.1298306 Orfeo en las poesías catalana y castellana de los siglos XVI–XVII: de la Arcadia al infierno Joan Mahiques Climent Pages: 1-20 | DOI: 10.1080/14753820.2017.1298318 Latin and Vernacular in the Cántico espiritual of St John of the Cross Terence O'reilly Pages: 1-16 | DOI: 10.1080/14753820.2017.1298319 'Pastor soy': fuentes ovidianas y neolatinas del Polifemo de Góngora Barry Taylor Pages: 1-12 | DOI: 10.1080/14753820.2017.1298325 The Poetry of Garcilaso: Bucolic Tradition and the Invention of a Visual Signature Roland Béhar Pages: 1-13 | DOI: 10.1080/14753820.2017.1298320 Listening Leaders Free Accessarticles from International Listening Association Lifetime Achievement AwardeesFind out more To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Aging & Mental Health are available online

The online platform for Taylor & Francis Online content New for Aging & Mental Health and online now on Taylor & Francis Online: Original Articles Characteristics and fall experiences of older adults with and without fear of falling outdoors Tracy Chippendale & Chang Dae Lee Pages: 1-7 | DOI: 10.1080/13607863.2017.1309639 Prevalence of depressive symptoms and its associated factors in older adults: a cross-sectional study in Kathmandu, Nepal Rajani Simkhada, Sharada P. Wasti, Vijay S. GC & Andrew C. K. Lee Pages: 1-6 | DOI: 10.1080/13607863.2017.1310803 Reviews Delirium clinical motor subtypes: a narrative review of the literature and insights from neurobiology James M. FitzGerald Pages: 1-13 | DOI: 10.1080/13607863.2017.1310802 Occupational Therapy Free Access Article Collection – click here. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Australian Journal of International Affairs are available online

The online platform for Taylor & Francis Online content New for Australian Journal of International Affairs and online now on Taylor & Francis Online: Original Articles Accountability and sexual exploitation and abuse in peace operations Sarah Smith Pages: 1-18 | DOI: 10.1080/10357718.2017.1287877 Find out more about the issues and challenges in Governing Asia. This collection includes free access papers on security challenges, the Abe and Modi administration, reflections on the Chinese Governance and more. Browse today! To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for AIDS Care are available online

The online platform for Taylor & Francis Online content New for AIDS Care and online now on Taylor & Francis Online: Original Articles Projected demographic composition of the United States population of people living with diagnosed HIV Julia E. Hood, Matthew R. Golden, James P. Hughes, Steven M. Goodreau, Azfar-E-Alam Siddiqi, Susan E. Buskin & Stephen E. Hawes Pages: 1-8 | DOI: 10.1080/09540121.2017.1308466 FREE ACCESS: Health Care for Women International: Research on Women's Health in Africa: Issues, Challenges & Opportunities To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Psychotherapy for depression among advanced, incurable cancer patients: a systematic review and meta-analysis

Publication date: Available online 11 April 2017
Source:Cancer Treatment Reviews
Author(s): Toru Okuyama, Tatsuo Akechi, Lisa Mackenzie, Toshi A. Furukawa
BackgroundThere is a high prevalence of depressive disorder and depressive symptoms among advanced, incurable cancer patients. Patients commonly report a preference for non-pharmacological treatments such as psychotherapy over pharmacological treatments for depression. The objective of this review was to investigate the effectiveness of psychotherapy for the treatment of depression in people with advanced, incurable cancer via a meta-analysis of randomized controlled trials (RCTs).MethodsWe searched research databases and clinical trial registries for studies published prior to June 2015. No language restrictions were applied when selecting studies. Cochrane Collaboration meta-analysis review methodology was used. All relevant RCTs comparing psychotherapy with control conditions on depression outcomes for adults with advanced cancer were eligible for inclusion. We calculated pooled effect sizes using Hedges g and a standardized mean difference (SMD) of change between baseline and post-treatment scores. Quality of evidence was rated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.ResultsOf 13 studies included in the review, 12 reported data suitable for meta-analysis. Psychotherapy was associated with moderate decrease in depression score (SMD −0.67, 95% confidence interval −1.06 to −0.29, P = 0.0005). Few studies focused on people with clinically diagnosed depression. Overall, quality of evidence across the included studies was rated as low, and heterogeneity was high.ConclusionsLow quality evidence suggests that psychotherapy is moderately more effective for the amelioration of symptoms of depression among advanced, incurable cancer patients than the control conditions. There is insufficient high-quality evidence supporting the effectiveness of psychotherapy for patients with clinically diagnosed depression.



http://ift.tt/2omIn0P

Increasing Frequency of Seborrheic Keratosis Diagnoses as a Favorable Consequence of Teledermatology-Based Skin Cancer Screening: A Cross-sectional Study of 34,553 Patients

Abstract

Background

Screening of skin cancer by teledermatology (TD) has improved the early detection of skin cancer by enhancing access to skin cancer clinics.

Objective

We sought to analyze how TD-based skin cancer screening has changed the frequency of consultations for benign lesions.

Patients and methods

A cross-sectional study including teleconsultations received during a 7-year period was conducted to analyze and compare the trendlines of each lesion type over the study period. Trendlines were analyzed using a linear regression model with the R-squared (R ²) test for goodness of fit.

Results

A total of 34,553 teleconsultations were included in the study. Seborrheic keratoses, followed by benign melanocytic lesions, were the most frequent lesions diagnosed. The pick-up rate for malignant lesions was 1:8.6 teleconsultations. Seborrheic keratoses and precancerous lesions showed a positive trendline with good fit to the linear model (R ² = 0.8 and R ² = 0.8, respectively). Tis-T1 malignant melanoma (in situ melanoma or melanoma with a Breslow thickness <1 mm) showed an increasing trendline with moderate-to-low fit to the model (R ² = 0.4).

Conclusions

TD-based screening of skin cancer is associated with an increasing rate of consultations involving seborrheic keratoses, which can be considered a consequence of improved access to dermatologists resulting from TD implementation.

http://ift.tt/2nY35Rd

Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients

Publication date: May 2017
Source:Neoplasia, Volume 19, Issue 5
Author(s): Zhiguang Xiao, Silvia Gaertner, Alicia Morresi-Hauf, Rebecca Genzel, Thomas Duell, Axel Ullrich, Pjotr G. Knyazev
The biologic plausibility of an association between type 2 diabetes mellitus (T2D) and lung cancer has received increasing attention, but the results of investigations remain largely inconclusive. In the present study we investigated the influence of the anti-diabetic drug metformin on the cytotoxic effects of EGFR targeted therapy and chemotherapy in 7 non-small cell lung cancer (NSCLC) cell lines and a cohort of lung cancer patients with/without T2D. In vitro cell viability assays indicated that metformin didn't potentiate the growth inhibitory effects of erlotinib at different doses in cell lines that are of distinct genetic background. EGFR downstream signaling evaluation further demonstrated that metformin, at its IC50 value, modified apoptosis caused in erlotinib or chemotherapeutic agent-treated cells via AKT activation and the inhibition of caspase 3 and PARP cleavages. These regulations were driven independently from EGFR, LKB1, KRAS, PTEN and p53 status. Metformin triggered autophagy (LC3B expression) was identified to interplay with apoptosis to attenuate the drug effect and postpone cancer cell death. In the retrospective study of 8 NSCLC patients, the administration of metformin did not induce statistically significant changes as assessed by immunohistochemical staining of pERK, pAKT and cleaved PARP. Consequently, the application of metformin for T2D NSCLC patients receiving chemo or EGFR targeted therapy should be considered with caution.



http://ift.tt/2p2aTDc

MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis

Publication date: April 2017
Source:Neoplasia, Volume 19, Issue 4
Author(s): Sanjay Yadav, Nishant Singh, Parag P. Shah, David A. Rowbotham, Danial Malik, Ankita Srivastav, Jai Shankar, Wan L. Lam, William W. Lockwood, Levi J. Beverly
Ubiquilin (UBQLN) proteins are adaptors thought to link ubiquitinated proteins to the proteasome. However, our lab has recently reported a previously unappreciated role for loss of UBQLN in lung cancer progression. In fact, UBQLN genes are lost in over 50% of lung cancer samples examined. However, a reason for the loss of UBQLN has not been proposed, nor has a selective pressure that could lead to deletion of UBQLN been reported. Diesel Exhaust Particles (DEP) are a major concern in the large cities of developing nations and DEP exposed populations are at an increased risk of developing a number of illnesses, including lung cancer. A connection between DEP and UBQLN has never been examined. In the present study, we determined the effect of DEP on lung cell lines and were interested to determine if UBQLN proteins could potentially play a protective role following treatment with DEP. Interestingly, we found that DEP treated cells have increased expression of UBQLN proteins. In fact, over-expression of UBQLN was capable of protecting cells from DEP toxicity. To investigate the mechanism by which DEP leads to increased UBQLN protein levels, we identified and interrogated microRNAs that were predicted to regulate UBQLN mRNA. We found that DEP decreases the oncogenic microRNA, MIR155. Further, we showed that MIR155 regulates the mRNA of UBQLN1 and UBQLN2 in cells, such that increased MIR155 expression increased cell invasion, migration, wound formation and clonogenicity in UBQLN-loss dependent manner. This is the first report of an environmental carcinogen regulating expression of UBQLN proteins. We show that exposure of cells to DEP causes an increase in UBQLN levels and that MIR155 regulates mRNA of UBQLN. Thus, we propose that DEP-induced repression of MIR155 leads to increased UBQLN levels, which in turn may be a selective pressure on lung cells to lose UBQLN1.



http://ift.tt/2oTtcxB

Targeting NF-kappa B Signaling by Artesunate Restores Sensitivity of Castrate-Resistant Prostate Cancer Cells to Antiandrogens

Publication date: April 2017
Source:Neoplasia, Volume 19, Issue 4
Author(s): Jessica J. Nunes, Swaroop K. Pandey, Anjali Yadav, Sakshi Goel, Bushra Ateeq
Androgen deprivation therapy (ADT) is the most preferred treatment for men with metastatic prostate cancer (PCa). However, the disease eventually progresses and develops resistance to ADT in majority of the patients, leading to the emergence of metastatic castration-resistant prostate cancer (mCRPC). Here, we assessed artesunate (AS), an artemisinin derivative, for its anticancer properties and ability to alleviate resistance to androgen receptor (AR) antagonists. We have shown AS in combination with bicalutamide (Bic) attenuates the oncogenic properties of the castrate-resistant (PC3, 22RV1) and androgen-responsive (LNCaP) PCa cells. Mechanistically, AS and Bic combination inhibits nuclear factor (NF)-κB signaling and decreases AR and/or AR-variant 7 expression via ubiquitin-mediated proteasomal degradation. The combination induces oxidative stress and apoptosis via survivin downregulation and caspase-3 activation, resulting in poly-ADP-ribose polymerase (PARP) cleavage. Moreover, preclinical castrate-resistant PC3 xenograft studies in NOD/SCID mice (n =28, seven per group) show remarkable tumor regression and significant reduction in lungs and bone metastases upon administering AS (50 mg/kg per day in two divided doses) and Bic (50 mg/kg per day) via oral gavage. Taken together, we for the first time provide a compelling preclinical rationale that AS could disrupt AR antagonist–mediated resistance observed in mCRPC. The current study also indicates that the therapeutic combination of Food and Drug Administration–approved AS or NF-κB inhibitors and AR antagonists may enhance the clinical efficacy in the treatment of mCRPC patients.



http://ift.tt/2p2bEw0

ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer

Publication date: April 2017
Source:Neoplasia, Volume 19, Issue 4
Author(s): Eun Young Kim, Ji Ye Jung, Arum Kim, Yoon Soo Chang, Se Kyu Kim
A subset of non-small cell lung cancer (NSCLC), which does not have a druggable driver mutation, is treated with platinum-based cytotoxic chemotherapy, but it develops resistance triggered by DNA damage responses. Here, we investigated the effect of activation of STAT3 by cisplatin on anti-apoptotic proteins and the effectiveness of a co-treatment with cisplatin and a BH3 mimetic, ABT-737. We analyzed the relationship between cisplatin and STAT3 pathway and effect of ABT-737, when combined with cisplatin in NSCLC cells and K-ras mutant mouse models. The synergism of this combination was evaluated by the Chou-Talalay Combination Index method. In vivo activity was evaluated by micro-CT. In NSCLC cells, there was a time and dose-dependent phosphorylation of SRC-JAK2-STAT3 by cisplatin, followed by increased expression of anti-apoptotic molecules. When the expression of the BCL-2 protein family members was evaluated in clinical samples, BCL-xL was most frequently overexpressed. Dominant negative STAT3 suppressed their expression, suggesting that STAT3 mediates cisplatin mediated overexpression of the anti-apoptotic molecules. ABT-737 displaced BCL-xL from mitochondria and induced oligomerization of BAK. ABT-737 itself showed cytotoxic effects and a combination of ABT-737 with cisplatin showed strong synergistic cytotoxicity. In a murine lung cancer model, co-treatment with ABT-737 and cisplatin induced significant tumor regression. These findings reveal a synergistic cytotoxic and anti-tumor activity of ABT-737 and cisplatin co-treatment in preclinical models, and suggest that clinical trials using this strategy may be beneficial in advanced NSCLC.



http://ift.tt/2oTfXNw

Inhibitors of GLUT/SLC2A Enhance the Action of BCNU and Temozolomide against High-Grade Gliomas

Publication date: April 2017
Source:Neoplasia, Volume 19, Issue 4
Author(s): Alberto Azzalin, Giulia Nato, Elena Parmigiani, Francesca Garello, Annalisa Buffo, Lorenzo Magrassi
Glucose transport across glioblastoma membranes plays a crucial role in maintaining the enhanced glycolysis typical of high-grade gliomas and glioblastoma. We tested the ability of two inhibitors of the glucose transporters GLUT/SLC2A superfamily, indinavir (IDV) and ritonavir (RTV), and of one inhibitor of the Na/glucose antiporter type 2 (SGLT2/SLC5A2) superfamily, phlorizin (PHZ), in decreasing glucose consumption and cell proliferation of human and murine glioblastoma cells. We found in vitro that RTV, active on at least three different GLUT/SLC2A transporters, was more effective than IDV, a specific inhibitor of GLUT4/SLC2A4, both in decreasing glucose consumption and lactate production and in inhibiting growth of U87MG and Hu197 human glioblastoma cell lines and primary cultures of human glioblastoma. PHZ was inactive on the same cells. Similar results were obtained when cells were grown in adherence or as 3D multicellular tumor spheroids. RTV treatment but not IDV treatment induced AMP-activated protein kinase (AMPKα) phosphorylation that paralleled the decrease in glycolytic activity and cell growth. IDV, but not RTV, induced an increase in GLUT1/SLC2A1 whose activity could compensate for the inhibition of GLUT4/SLC2A4 by IDV. RTV and IDV pass poorly the blood brain barrier and are unlikely to reach sufficient liquoral concentrations in vivo to inhibit glioblastoma growth as single agents. Isobologram analysis of the association of RTV or IDV and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide (TMZ) indicated synergy only with RTV on inhibition of glioblastoma cells. Finally, we tested in vivo the combination of RTV and BCNU on established GL261 tumors. This drug combination increased the overall survival and allowed a five-fold reduction in the dose of BCNU.



http://ift.tt/2p2qfaH

E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells

Publication date: April 2017
Source:Neoplasia, Volume 19, Issue 4
Author(s): Ling Xu, Ye Zhang, Xiujuan Qu, Xiaofang Che, Tianshu Guo, Ying Cai, Aodi Li, Danni Li, Ce Li, Ti Wen, Yibo Fan, Kezuo Hou, Yanju Ma, Xuejun Hu, Yunpeng Liu
Multiple drug resistance (MDR) and metastasis are two major factors that contribute to the failure of cancer treatment. However, the relationship between MDR and metastasis has not been characterized. Additionally, the role of the E3 ubiquitin ligase Cbl-b in metastasis of MDR gastric and breast cancer is not well known. In the present study, we found that MDR gastric and breast cancer cells possess a typical mesenchymal phenotype and enhanced cell migration capacity. Additionally, Cbl-b is poorly expressed in MDR gastric and breast cancer cells. In MDR gastric adenocarcinoma tissues, gastric cancer patients with low Cbl-b expression were more likely to have tumor invasion (P=.016) and lymph node metastasis (P=.007). Moreover, overexpression of Cbl-b reduced cell migration in MDR cell cultures both in vitro and in vivo. Cbl-b overexpression also prevented EMT by inducing ubiquitination and degradation of EGFR, leading to inhibition of the EGFR-ERK/Akt-miR-200c-ZEB1 axis. However, further overexpression of EGFR on a background of Cbl-b overexpression restored both the mesenchymal phenotype and cell migration capacity of MDR gastric and breast cancer cells. These results suggest that Cbl-b is an important factor for maintenance of the epithelial phenotype and inhibition of cell migration in MDR gastric and breast cancer cells.



http://ift.tt/2oTeExR

Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on Monoubiquitinaton

Publication date: April 2017
Source:Neoplasia, Volume 19, Issue 4
Author(s): Henrick Horita, Andy Law, Soonjin Hong, Kim Middleton
A set of high-affinity, high-specificity posttranslational modification (PTM) enrichment tools was developed to generate an unbiased snapshot of four key PTM profiles (tyrosine phosphorylation, acetylation, ubiquitination, and SUMOylation 2/3) for the clinically important protein programmed cell death ligand 1 (PD-L1). The results showed that epidermal growth factor (EGF) treatment induced tyrosine phosphorylation, acetylation, and ubiquitination of PD-L1. Further characterization of EGF-induced PD-L1 ubiquitination revealed a significant increase in mono- and multiubiquitination of PD-L1 that occurred on glycosylated PD-L1. EGF induced mono- and multiubiquitination of PD-L1 preceded EGF-induced increases in PD-L1 protein levels. Chemical inhibitors of the EGFR pathway, gefitnib and SCH772984, suppressed PD-L1 mono- and multiubiquitination, and inhibition of the ubiquitin E1 activating enzyme, with the chemical inhibitor PYR41, was sufficient to block EGF-stimulated increases in PD-L1 protein levels. This study highlights the significance of identifying novel PTMs for PD-L1 and reveals potentially critical regulatory mechanisms that may be valuable therapeutic targets. In a broader context, this report validates an approach whereby one can gain insight into novel mechanisms of action by a simple and unbiased analysis of a PTM profile of potentially any endogenous protein of interest.



http://ift.tt/2p28fNX

Corrigendum to “Epidermal Growth Factor Cytoplasmic Domain Affects ErbB Protein Degradation by the Lysosomal and Ubiquitin–Proteasome Pathway in Human Cancer Cells” [Neoplasia 14 (2012) 396–409]

Publication date: April 2017
Source:Neoplasia, Volume 19, Issue 4
Author(s): Aleksandra Glogowska, Jörg Stetefeld, Ekkehard Weber, Saeid Ghavami, Cuong Hoang-Vu, Thomas Klonisch




http://ift.tt/2oThMd2

Osteolytic lesions resulting from opportunistic infections

Publication date: Available online 10 April 2017
Source:The Kaohsiung Journal of Medical Sciences
Author(s): Wei-Sin Li, Wen-Chi Huang, Cheng-Lung Ku, Chen-Hsiang Lee




http://ift.tt/2oTq8BL

Correlation between change of tongue area and skeletal stability after correction of mandibular prognathism

Publication date: Available online 10 April 2017
Source:The Kaohsiung Journal of Medical Sciences
Author(s): Yu-Chuan Tseng, Ju-Hui Wu, Chun-Ming Chen, Kun-Jung Hsu
The purpose of this study was to investigate the correlation between postoperative stability and a change in tongue area after treatment of mandibular prognathism. Twenty-six patients, who were treated for mandibular prognathism using intraoral vertical ramus osteotomy, were evaluated cephalometrically. A set of three standardized lateral cephalograms were obtained from each participant preoperatively (T1), immediately postoperatively (T2), and after 2 years postoperatively (T3). Student t test and Pearson correlation coefficient were used for statistical analysis. Immediately after the surgery (T12), the setback of the menton (Me) was 12.9 mm (p<0.001) and the tongue area had significantly increased to 105.8 mm² (p=0.047). At a 2-year follow-up to examine postsurgical stability (T23), the Me exhibited a forward movement of 0.6 mm (p=0.363) and the tongue area had significantly decreased to 124.3 mm² (p=0.004). Pearson correlation coefficient test revealed no statistical significance between postoperative stability and change in tongue area. The tongue area significantly increased during the T12 period and decreased during the T23 period. There is no significant correlation between postoperative skeletal relapse and a change in tongue area.



http://ift.tt/2p2ev8q

Sex differences in athletic performance emerge coinciding with the onset of male puberty

Abstract

Background

Male performance in athletic events begins to exceed that of age-matched females during early adolescence but the timing of this divergence relative to the onset of male puberty and the rise of circulating testosterone remains poorly defined.

Design

This study is a secondary quantitative analysis of four published sources which aimed to define the timing of the gender divergence in athletic performance and relating it to the rise in circulating testosterone due to male puberty.

Data: Four data sources reflecting elite swimming and running and jumping track and field events as well as hand grip strength in non-athletes were analysed to define the age-specific gender differences through adolescence and their relationship to the rising circulating testosterone during male puberty.

Results

The onset and tempo of gender divergence was very similar for swimming, running and jumping events as well as the hand grip strength in non-athletes and all closely paralleled the rise in circulating testosterone in adolescent boys.

Conclusions

The gender divergence in athletic performance begins at the age of 12-13 years and reaches adult plateau in the late teenage years with the timing and tempo closely parallel to the rise of circulating testosterone in boys during puberty.

This article is protected by copyright. All rights reserved.

http://ift.tt/2o2wXNb

Submaximal doses of ghrelin do not inhibit gonadotrophin levels but stimulate prolactin secretion in postmenopausal women

Summary

Objective

An inhibitory effect of ghrelin on gonadotrophin secretion has been reported in normally menstruating women possibly modulated by endogenous estrogen. The aim of this study was to examine the effect of ghrelin on gonadotrophin and PRL secretion in estrogen-deprived postmenopausal women.

Design

Prospective intervention study.

Patients and Measurements

Ten healthy postmenopausal volunteer women were studied during two 15-day periods of estrogen treatment (A and B) a month apart. Four experiments (Exp) were performed in total, two on day 1 (Exp 1A and Exp 1B) and two on day 15 (Exp 15A and Exp 15B) of the two periods. The women received in Exp 1A and in Exp 15A two iv injections of ghrelin (0.15 μg/kg at time 0 min and 0.30 μg/kg at time 90 min) and in Exp1B and in Exp 15B normal saline (2 ml) respectively. Blood samples were taken at -15, 0, 30,60, 90, 120, 150 and 180 min.

Results

After estrogen treatment, late follicular phase serum estradiol levels were attained on day 15 of periods A and B. Ghrelin administration did not affect serum levels of FSH and LH, whereas it increased significantly those of GH and PRL. In Exp 15A, serum PRL increment in response to ghrelin (area under the curve, net increment) was significantly greater than in Exp 1A (P<0.05).

Conclusions

The present study demonstrates for the first time that in estrogen-deprived postmenopausal women, ghrelin administration affects neither FSH nor LH levels but stimulates PRL secretion, that is amplified by exogenous estrogen administration.

This article is protected by copyright. All rights reserved.

http://ift.tt/2omdb1x