Scholar : Scholar Alert - [ intitle:laryngeal ]

Scholar Alert: [ intitle:laryngeal ]

Overground endoscopy in 311 Thoroughbred racehorses: findings and correlation to resting laryngeal function

JA Davison, JM Lumsden, RC Boston, BJ Ahern - Australian Veterinary Journal, 2017

Objective To review a large number of equine overground endoscopy (OGE) examinations
to determine the incidence of dynamic upper airway obstructions (DUAO); correlations were
explored with laryngeal endoscopy findings at rest and abnormal exercising respiratory

Clinicopathologic Findings and Treatment Outcome of Laryngectomized Patients with Laryngeal Cancer and Hypopharyngeal Cancer: An Experience in Thailand

N Larbcharoensub, D Wattanatranon, J Leopairut… - Asian Pacific journal of …, 2017

Objective: To evaluate the clinicopathologic findings and treatment outcome in
laryngectomized patients with laryngeal cancer and hypopharyngeal cancer. Materials and
Methods: The authors retrospectively reviewed the medical records of 212 patients who had

3‐dimensional (3D) tissue‐engineered skeletal muscle for laryngeal reconstruction

S Brookes, S Voytik‐Harbin, H Zhang, S Halum - The Laryngoscope, 2017

Objective There is an unmet need for tissue-engineered three-dimensional (3D) muscle
constructs for laryngeal reconstruction. Functional engineered muscle could be used to
repair postoncologic or traumatic defects or to medialize the vocal fold in cases of

Voice rest after laryngeal surgery: what's the evidence?.

M Kaneko, S Hirano - Current Opinion in Otolaryngology & Head and Neck …, 2017

Summary: It seems that early vocal stimulation may enhance the wound healing process in
the vocal fold. More basic and clinical researches are warranted to investigate appropriate
timing of initiation of stimulation, as well as the type and amount of stimulation that are

Learning curve for robotic esophagectomy and dissection of bilateral recurrent laryngeal nerve nodes for esophageal cancer

SY Park, DJ Kim, DR Kang, SJ Haam - Diseases of the Esophagus, 2017

Summary Dissection of bilateral recurrent laryngeal nerve (RLN) nodes is a technically
demanding procedure, but robotic systems have been useful for RLN node dissection. This
retrospective study investigated the learning curve for bilateral RLN node dissection in

Comparison of the laryngeal mask airway supreme and the i-gel in paralysed elderly patients: A randomised controlled trial.

MH Kim, JH Lee, YS Choi, S Park, S Shin - European Journal of Anaesthesiology ( …, 2017

BACKGROUND: The laryngeal mask airway supreme (LMA-S) and i-gel are both popular
second-generation supraglottic airway devices that have been widely studied in surgical
patients, but their differences in clinical performance in the elderly are not clear.

Overexpression of Antiangiogenic Vascular Endothelial Growth Factor Isoform and Splicing Regulatory Factors in Oral, Laryngeal and Pharyngeal Squamous Cell …

PM Biselli-Chicote, JM Biselli, BR Cunha, R Castro… - Asian Pacific journal of …, 2017

Background: Overexpression of proangiogenic vascular endothelial growth factor A family
VEGFAxxx is associated with tumor growth and metastasis. The role of the alternatively
spliced antiangiogenic family VEGFAxxxb is poorly investigated in head and neck

---

This Google Scholar Alert is brought to you by Google.

Cancel alert
List my alerts

Scholar : Ειδοποίηση Μελετητή - [ ΠΑΛΙΝ

Ειδοποίηση Μελετητή:[ ΠΑΛΙΝΔΡΟΜΗΣΗ ]

Η ποιότητα ζωής στο βαρέως πάσχοντα

Λ Σαμαρτζής - 2017

... και του ιδιοσυγκρασιακού άγχους (State-Trait Anxiety Inventory form Y) και για την αξιολόγηση της
προσωπικότητας τους (NEO-FFI).Ακολούθησε στατιστική ανάλυση με τη μέθοδο την πολλαπλής
γραμμικής παλινδρόμησης όπου Γραμμική παλινδρόμηση ωε εξαρτημένη ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ ΑΠΟΚΑ

Ειδοποίηση Μελετητή:[ ΑΠΟΚΑΤΑΣΤΑΣΗ ]

Χρόνια αποφρακτική πνευμονοπάθεια: αποκατάσταση ασθενών στην πρωτοβάθμια φροντίδα υγείας

Γ Μητώνας - 2017

Εισαγωγή: Η ανάγκη για μια διεπιστημονική στρατηγική στη διαχείριση της Χρόνιας
Αποφρακτικής Πνευμονοπάθειας (ΧΑΠ) σε επίπεδο κοινότητας στην Ελλάδα θέτει σημαντικά
ερωτήματα, δεδομένων των αυστηρών μέτρων λιτότητας που επιβάλλονται στην παρούσα

Η ποιότητα ζωής στο βαρέως πάσχοντα

Λ Σαμαρτζής - 2017

... ασθενή με ΧΚΑ, 3)ότι η κατάθλιψη, άγχος, προσωπικότητα, σχετίζονται ανεξάρτητα με τη Ποιότητα
Ζωής του ασθενή με ΧΚΑ, 4)ότι η άσκηση μειώνει την κατάθλιψη σε βαθμό συγκρίσιμο με SSRIs,
και 5)ότι οι ψυχοκοινωνικές παρεμβάσεις κατά την αποκατάσταση βελτιώνουν την ...

[PDF] Κοινωνική αποδοχή ανανεώσιμων πηγών ενέργειας

Ν Χατζηγιαννάκης, Β Δερβεντλής - 2017

Page 1. 1 ΑΝΩΤΑΤΟ ΤΕΧΝΟΛΟΓΙΚΟ ΙΔΡΥΜΑ ΠΕΙΡΑΙΑ ΣΧΟΛΗ ΔΙΟΙΚΗΣΗΣ ΕΠΙΧΕΙΡΗΣΕΩΝ
Κοινωνική Αποδοχή Ανανεώσιμων Πηγών Ενέργειας ΕΠΟΠΤΗΣ ΚΑΘΗΓΗΤΗΣ: ΜΙΛΤΙΑΔΗΣ
ΧΑΛΙΚΙΑΣ ΣΠΟΥΔΑΣΤΕΣ: ΝΙΚΟΛΑΣ ΧΑΤΖΗΓΙΑΝΝΑΚΗΣ ΑΜ 7610 ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ Laryngomal

Ειδοποίηση Μελετητή:[ Laryngomalacia ]

[HTML] Association of breathing sound spectra with glottal dimensions in exercise-induced vocal cord dysfunction

A Geneid, LM Aaltonen, L Porra, J Peltonen, K Palmu… - European Archives of Oto- …, 2017

... [11] as a tool in the assess- ment of EIVCD and exercise-induced laryngomalacia diag- noses. ...
The results showed that exercise-induced laryngomalacia and EIVCD are two separate
conditions, both causing laryngeal obstruction, but at different levels. ...

[PDF] Delineating the phenotypic spectrum of Bainbridge-Ropers syndrome: Twelve new patients with de novo, heterozygous, loss-of-function mutations in ASXL3 and …

M Balasubramanian, J Willoughby, AE Fry, A Weber…

Page 1. Balasubramanian and Willoughby et al Delineating the phenotypic spectrum
of Bainbridge-Ropers syndrome: Twelve new patients with de novo, heterozygous,
loss-of-function mutations in ASXL3 and review of published literature ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ Laryngotra

Ειδοποίηση Μελετητή:[ Laryngotracheal reconstruction ]

[PDF] PEDIATRIC REVIEW

SP Kanotra

... FIGURE 3 A laryngotracheal reconstruction using costal cartilage graft in a 4-year-old child with
subglottic stenosis. Notice the graft abutting the stoma. Page 4. ... (B) A 3D reconstructed CT scan
of the patient showing the tracheal stenosis. (C) Exposure from the tracheal resection. ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ ΚΑΡΚΙ

Ειδοποίηση Μελετητή:[ ΚΑΡΚΙΝΩΜΑ ]

Μελέτη των μικρομεταστάσεων στους βουβωνικούς λεμφαδένες ασθενών με καρκίνωμα αιδοίου και εκτίμηση της προγνωστικής σημασίας τους στην πορεία της νόσου

Γ Δερδελής - 2017

Σκοπός: Οι μεταστάσεις στους βουβωνικούς λεμφαδένες αποτελούν σημαντικό προγνωστικό
παράγοντα στην επιβίωση των ασθενών με καρκίνο του αιδοίου. Μέχρι και σήμερα όμως δεν
είναι γνωστή η σημασία των μικρομεταστάσεων σην περιοχή αυτή. Στόχος της παρούσας υπό

[PDF] Σχεδιασμός, σύνθεση και βιολογική αξιολογήση βιοσυζευγμάτων Γεμσιταβίνης για εκλεκτική στόχευση καρκινικών κυττάρων

Ε Βρεττός - 2017

... Το κυτταροτοξικό (αντικαρκινικό) φάρμακο συνδέεται χημικώς (συζευγμένο χρησιμοποιώντας
δισουλφίδιο ή μη-διασπώμενο θειοαιθέρα) με ένα μονοκλωνικό αντίσωμα που αναγνωρίζει ένα
ειδικό αντιγόνο που συνδυάζεται με καρκίνωμα, καθιστώντας το συνδυασμό φαρμάκων ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ intitle:Bi

Ειδοποίηση Μελετητή:[ intitle:Bioprinting ]

Segmentation and Measurement of Chronic Wounds for Bioprinting.

P Gholami, MA Ahmadi-Pajouh, N Abolftahi… - IEEE journal of biomedical …, 2017

... 2017 Aug 23. doi: 10.1109/JBHI.2017.2743526. [Epub ahead of print] Segmentation and
Measurement of Chronic Wounds for Bioprinting. Gholami P, Ahmadi-Pajouh MA, Abolftahi N,
Hamarneh G, Kayvanrad M. OBJECTIVE: To provide a proof-of-concept tool for segmenting

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ ΔΥΣΠΝ

Ειδοποίηση Μελετητή:[ ΔΥΣΠΝΟΙΑ ]

Η ποιότητα ζωής στο βαρέως πάσχοντα

Λ Σαμαρτζής - 2017

... Περίληψη. Οι ασθενείς με χρόνια καρδιακή ανεπάρκεια υποφέρουν από σωματικά και
ψυχοκοινωνικά προβλήματα με τελικές εκδηλώσεις τη δύσπνοια, την εύκολη κόπωση, τη μειωμένη
λειτουργικότητα στις καθημερινές εκδηλώσεις και τελικά βιώνουν χαμηλή ποιότητα ζωής. ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ ΥΠΟΦΥ

Ειδοποίηση Μελετητή:[ ΥΠΟΦΥΣΗ ΥΠΟΘΑΛΑΜΟΣ ]

[PDF] Σχεδιασμός, σύνθεση και βιολογική αξιολογήση βιοσυζευγμάτων Γεμσιταβίνης για εκλεκτική στόχευση καρκινικών κυττάρων

Ε Βρεττός - 2017

Page 1. Σχεδιασμός, σύνθεση και βιολογική αξιολόγηση βιοσυζευγμάτων Γεμσιταβίνης για εκλεκτική
στόχευση καρκινικών κυττάρων ΒΡΕΤΤΟΣ ΕΙΡΗΝΑΙΟΣ ΧΗΜΙΚΟΣ ΜΕΤΑΠΤΥΧΙΑΚΟ ΔΙΠΛΩΜΑ
ΕΙΔΙΚΕΥΣΗΣ ΕΠΙΒΛΕΠΩΝ ΚΑΘΗΓΗΤΗΣ: ΤΖΑΚΟΣ ΑΝΔΡΕΑΣ ΙΩΑΝΝΙΝΑ 2017 ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Scholar : Ειδοποίηση Μελετητή - [ Undersea

Ειδοποίηση Μελετητή:[ Undersea "Hyperbaric Medicine" ]

[PDF] Mission trip to Northern Nigeria supports local Adventist hospital, regional outreach

J Ponder

... Participation in Undersea and Hyperbaric Medical Society accreditation is voluntary. Laren Tan,
MD, medical director for hyperbaric medicine at Loma Linda University Medical Center, said the
accreditation demonstrates the organization's com- mitment to the highest standards ...

---

Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

Ακύρωση ειδοποίησης
Δημιουργία λίστας των ειδοποιήσεών μου

Detection of complex genomic signatures associated with risk in plasma cell disorders

Publication date: Available online 1 September 2017
Source:Cancer Genetics
Author(s): Nadine K Berry, Amanda Dixon-McIver, Rodney J. Scott, Philip Rowlings, Anoop K Enjeti
Plasma cell disorders (PCD) range from benign to highly malignant disease. The ability to detect risk-stratifying aberrations based on cytogenetic and molecular genetic assays plays an increasing role in therapeutic. In this study, 58 patients were chosen for screening by comparative genomic hybridisation microarray (aCGH) to identify the new high-risk prognostic markers of chromothripsis and chromoanasynthesis. All patients had an unequivocal clinical diagnosis of a plasma cell disorder (plasma cell myeloma (PCM)(n=51) or monoclonal gammopathy of undetermined significance (MGUS)(n=7)) and an abnormal FISH result. There were a total of 17 complex genomic events identified across 9 patient samples, which were selected for further investigation by high definition single nucleotide polymorphism (HD-SNP) microarray. Each event was analysed and characterised for chromothripsis, chromoanasysnthesis or a complex step-wise chromosomal event. We describe an effective method to identify the new high-risk prognostic markers of chromothripsis and chromoanasynthesis in plasma cell disorders.



http://ift.tt/2wZS2QC

The worldwide diversity of scalp seborrhoea, as daily experienced by seven human ethnic groups

Abstract

Objective

The re-greasing process and kinetics of the human scalp, post shampooing, has been previously documented, in vivo, on a few Caucasian subjects. The objective of the presented research is to extend such knowledge over 7 different ethnic groups.

Methods

The post shampooing re-greasing kinetics of the scalp was studied on 1325 subjects (women and men of two distinct age classes) from 7 different ethnic groups in their residential and native country. Sebum amounts were determined onto small shaved scalp areas at various times post shampooing, using the Sebumeter^® technique.

Results

As previously published on Caucasian subjects, scalp re-greasing process follows a hyperbolic-like kinetics over days. However, amounts of collected sebum highly vary with ethnicity. As recorded through the Casual Level (CL) at the equilibrium phase, 2 to 3 days post-shampooing, the highest amount of sebum was found in African American subjects, followed in descending order by Caucasian American, Japanese, Chinese, Thai, Caucasian European and Indian subjects, the latter showing very low values. Lower amounts of sebum were recorded in the older age-class in all ethnics, as compared to the younger one and male subjects were found higher sebum producers than women, irrespective of ethnicity.

Conclusion

The kinetics and slopes of the re-greasing process of the human scalp appear similar in all ethnic groups studied. Despite, striking quantitative differences are found between the 7 ethnic groups, resulting from different sebaceous production levels and scalp hygiene routines.

This article is protected by copyright. All rights reserved.

http://ift.tt/2grUkgz

Influence of UV filters on the texture profile and efficacy of a cosmetic formulation

Abstract

Objective

Considering that many cosmetic products contain UV filters in their composition and that few studies have evaluated the role of UV filters in the physical properties and clinical efficacy of these products, the aim of the present study was to assess the influence of UV filters on the properties and immediate effects of a cosmetic formulation.

Methods

Four cosmetic formulations, vehicle (V), vehicle containing UV filters (F), vehicle containing cassava polysaccharides and alfalfa (A) oligosaccharides and vehicle containing UV filters plus cassava polysaccharides and alfalfa oligosaccharides (multifunctional formulation, M) were developed. The texture profile of the formulations was analyzed with a TA.XT plus Texturometer^®. Twenty female volunteers aged 39 to 45 years were then selected for the assessment of immediate clinical efficacy of the formulations under study and of transepidermal water loss, stratum corneum water content and microrelief of the skin obtained with their use.

Results

The presence of UV filters resulted in an improvement of the physical properties of the multifunctional cosmetic formulation (M) and of skin microrelief. However, the presence of UV filters also caused a significant decrease of hydration.

Conclusion

The presence of sunscreens had a negative influence on immediate skin hydration and transepidermal water loss. On the other hand, it positively influenced parameters related to the physical properties of the multifunctional formulation and skin microrelief. Thus, we conclude that the influence of UV filters on the development of cosmetic formulations is an important factor to be considered since it can have either positive or negative effects on the efficacy of the product.

This article is protected by copyright. All rights reserved.

http://ift.tt/2wrW6HE

Comparative expression profiling of AtRAD5B and AtNDL1: Hints towards a role in G protein mediated signaling

Publication date: Available online 1 September 2017
Source:Gene Expression Patterns
Author(s): Nisha Khatri, Swati Singh, Nasmeen Hakim, Yashwanti Mudgil
Arabidopsis AtRAD5B encodes for a putative helicase of the class SWItch/Sucrose Non-Fermentable (SWI/SNF) ATPases. We identified AtRAD5B as an interactor of N-MYC DOWNREGULATED-LIKE1 (AtNDL1) in a yeast two-hybrid screen. AtNDL1 is a G protein signaling component which regulates auxin transport and gradients together with GTP binding protein beta 1 (AGB1). Auxin gradients are known to recruit SWI/SNF remodeling complexes to the chromatin and regulate expression of genes involved in flower and leaf formation. In current study, a comparative spatial and temporal co-expression/localization analysis of AtNDL1, AGB1 with AtRAD5B was carried out in order to explore the possibility of their coexistence in a common signaling network. Translational fusion (GUS) of AtNDL1 and AtRAD5B in seedlings and reproductive organs revealed that both shared similar expression patterns with the highest expression observed in male reproductive organs. Moreover, they shared similar domains of localization in roots, suggesting their potential functioning together in reproductive and root development processes. This study predicts the existence of a signaling network involving AtNDL1, AGB1 with AtRAD5B.



http://ift.tt/2es1a4X

Anatomical connections between the buccinator and the tendons of the temporalis

Publication date: Available online 1 September 2017
Source:Annals of Anatomy - Anatomischer Anzeiger
Author(s): Mi-Sun Hur
The aim of this study was to clarify the anatomical relationship between the buccinator and the temporalis in order to improve understanding of the precise and coordinated movements of the mouth and the mandible. The buccinator and the temporalis were investigated in 72 hemifaces from Korean cadavers. Removing the buccal fat pad from the buccinator revealed that the fascia encircled the space between the superficial and deep tendons of the temporalis laterally, and the external surface of the buccinator medially in all specimens (100%). The fascia was located between the buccinator and the tendons of the temporalis, thereby connecting these two muscles. The fascial space was filled with connective tissue, and the buccal nerve and artery passed through this space. The inferior fibers of the buccinator arose from the anterior portion of the deep tendon of the temporalis in all specimens (100%). The anterior portion of the deep tendon of the temporalis extended forward obliquely between the ramus and body of the mandible. Thus, both the anterior portion of the deep tendon of the temporalis and its attaching inferior muscle fibers of the buccinator coursed obliquely. The above observations indicate that the connecting fascia between the buccinator and tendons of the temporalis and the inferior fibers of the buccinator that were attached to the deep tendon of the temporalis could assist in coordinatation of the movements of the mandibular region and the mouth angle in the timing and strength of contraction of the muscles during mastication, facial expression, and speech.



http://ift.tt/2ww4rZs

Can Skull Form Predict the Shape of the Temporomandibular Joint? A Study Using Geometric Morphometrics on the Skulls of Wolves and Domestic Dogs

Publication date: Available online 1 September 2017
Source:Annals of Anatomy - Anatomischer Anzeiger
Author(s): Stefan Curth, Martin S. Fischer, Kornelius Kupczik
The temporomandibular joint (TMJ) conducts and restrains masticatory movements between the mammalian cranium and the mandible. Through this functional integration, TMJ morphology in wild mammals is strongly correlated with diet, resulting in a wide range of TMJ variations. However, in artificially selected and closely related domestic dogs, dietary specialisations between breeds can be ruled out as a diversifying factor although they display an enormous variation in TMJ morphology. This raises the question of the origin of this variation. Here we hypothesise that, even in the face of reduced functional demands, TMJ shape in dogs can be predicted by skull form; i.e. that the TMJ is still highly integrated in the dog skull. If true, TMJ variation in the dog would be a plain by-product of the enormous cranial variation in dogs and its genetic causes. We addressed this hypothesis using geometric morphometry on a data set of 214 dog and 60 wolf skulls. We digitized 53 three-dimensional landmarks of the skull and the TMJ on CT-based segmentations and compared (1) the variation between domestic dog and wolf TMJs (via principal component analysis) and (2) the pattern of covariation of skull size, flexion and rostrum length with TMJ shape (via regression of centroid size on shape and partial least squares analyses). We show that the TMJ in domestic dogs is significantly more diverse than in wolves: its shape covaries significantly with skull size, flexion and rostrum proportions in patterns which resemble those observed in primates. Similar patterns in canids, which are carnivorous, and primates, which are mostly frugivorous imply the existence of basic TMJ integration patterns which are independent of dietary adaptations. However, only limited amounts of TMJ variation in dogs can be explained by simple covariation with overall skull geometry. This implies that the final TMJ shape is gained partially independently of the rest of the skull.



http://ift.tt/2vzClzd

In vivo characterization of the murine venous system before and during dobutamine stimulation: implications for preclinical models of venous disease

Publication date: Available online 1 September 2017
Source:Annals of Anatomy - Anatomischer Anzeiger
Author(s): Olivia R. Palmer, Calvin B. Chiu, Amos Cao, Ulrich M. Scheven, Jose A. Diaz, Joan M. Greve
Although widely used as a preclinical model for studying venous diseases, there is a scarcity of in vivo characterizations of the naïve murine venous system. Additionally, previous studies on naïve veins (ex vivo) have not included the influence of surrounding structures and biomechanical forces. Using MRI, we noninvasively quantified the cross-sectional area, cyclic strain, and circularity of the venous system in young and old, male and female C57BL/6 mice. We investigated the most common venous locations used to perform venous disease research: the common jugular vein, suprarenal inferior vena cava (IVC), infrarenal IVC, common iliac vein, and common femoral vein. Our results elucidate age-dependent changes in venous cross-sectional area, which varied by location. Maximum cyclic strain, a parameter of lumen expansion, showed 10% change across the cardiac cycle, approximately half the magnitude of arteries. Veins demonstrated noncircular shapes, particularly in the core vasculature. The cardiovascular stressor dobutamine had only a small impact on the venous system. Also, our data demonstrate that the peripheral veins tend to decrease in cross-sectional area and circularity with age. Conversely, the IVC tends to increase in size and circularity with age, with males exhibiting larger variability in response to dobutamine compared to females. This work provides a foundation for drawing age and sex comparisons in disease models, and represents the first in vivo characterization of the murine venous system at rest and during the application of a pharmacological exercise surrogate.



http://ift.tt/2ww4hRQ

Expression of myosin heavy chain isoforms mRNA transcripts in the temporalis muscle of common chimpanzees (Pan troglodytes)

Publication date: Available online 1 September 2017
Source:Annals of Anatomy - Anatomischer Anzeiger
Author(s): Neus Ciurana, Rosa Artells, Carmen Muñoz, Júlia Arias-Martorell, Gaëlle Bello-Hellegouarch, Aroa Casado, Elisabeth Cuesta, Alejandro Pérez-Pérez, Juan Francisco Pastor, Josep Maria Potau
PurposeThe common chimpanzee (Pan troglodytes) is the primate that is phylogenetically most closely related to humans (Homo sapiens). In order to shed light on the anatomy and function of the temporalis muscle in the chimpanzee, we have analyzed the expression patterns of the mRNA transcripts of the myosin heavy chain (MyHC) isoforms in different parts of the muscle.Basic proceduresWe dissected the superficial, deep and sphenomandibularis portions of the temporalis muscle in five adult P. troglodytes and quantified the expression of the mRNA transcripts of the MyHC isoforms in each portion using real-time quantitative polymerase chain reaction.Main findingsWe observed significant differences in the patterns of expression of the mRNA transcripts of the MyHC-IIM isoform between the sphenomandibularis portion and the anterior superficial temporalis (33.6% vs 47.0%; P=0.032) and between the sphenomandibularis portion and the anterior deep temporalis (33.6% vs 43.0; P=0.016). We also observed non-significant differences between the patterns of expression in the anterior and posterior superficial temporalis.Principal conclusionsThe differential expression patterns of the mRNA transcripts of the MyHC isoforms in the temporalis muscle in P. troglodytes may be related to the functional differences that have been observed in electromyographic studies in other species of primates. Our findings can be applicable to the fields of comparative anatomy, evolutionary anatomy, and anthropology.



http://ift.tt/2vzs9Xq

Ultrasound variants of autoimmune thyroiditis in children and adolescents and their clinical implication in relation to papillary thyroid carcinoma development

Abstract

Background

The prevalence of autoimmune thyroiditis (AIT) and papillary thyroid carcinoma (PTC) is rising in children and adolescents, and the coincidence of AIT and PTC is as high as 6.3–43%.

Objective

To investigate the ultrasound manifestation of AIT in relation to PTC development in paediatric patients.

Patients

179 paediatric patients (133 females), mean (SD) age: 13.9 (3.03) years diagnosed with AIT and referred for ultrasound evaluation. Eight patients were diagnosed with PTC (6 females).

Methods

Retrospective analysis of thyroid ultrasound scans of patients diagnosed with AIT. Thyroid and autoimmune status was assessed based on TSH, fT4, fT3 and increased aTPO and/or aTG and/or TRAB levels. In patients with PTC, total thyroidectomy was performed.

Results

Analysis of thyroid US scans revealed that the following five ultrasound variants of AIT were observed in 179 patients: the most common in 35.2%—diffuse thyroiditis with hypoechogenic background and normoechogenic parenchyma, in 30.2%—diffuse thyroiditis with irregular background, in 18.9% nodular variant with normoechogenic background, in 11.7%—micronodulations and in 3.9%—diffuse hypoechogenic background. Eight cases of PTC were diagnosed in nodular variant of AIT with normoechogenic irregular background.

Conclusion

Patients with AIT and nodular variant with normoechogenic irregular background of the thyroid gland on US scans are in the risk group of developing PTC and should be followed up with regular neck US assessment.

http://ift.tt/2esb7PL

Remediation mechanisms of mercapto-grafted palygorskite for cadmium pollutant in paddy soil

Abstract

The immobilization agent was the key factor that determined the success of remediation of heavy metal polluted soil. In this study, mercapto-grafted palygorskite (MP) as a novel and efficient immobilization agent was utilized for the remediation of Cd-polluted paddy soil in pot trials, and the remediation mechanisms were investigated in the aspect of soil chemistry and plant physiology with different rice cultivars as model plants. Mercapto-grafted palygorskite at applied doses of 0.1–0.3% could reduce Cd contents of brown rice and straws of different cultivars significantly. Both reduced DTPA-extractable Cd contents in rhizosphere and non-rhizosphere soil and decreasing Cd contents in iron plaques on rice root surfaces confirmed that MP was an efficient immobilization agent for Cd pollutant in paddy soil. In the aspect of soil chemistry, the pH values of rhizosphere and non-rhizosphere soils had no statistical changes in the MP treatment groups, but their zeta potentials decreased obviously, indicating that MP could enhance the fixation or sorption of Cd on soil compositions. In the aspect of antioxidant system, MP could increase POD activity of rice roots significantly to alleviate the stress of Cd to roots, and resulted in the decrease of T-AOC, SOD, and CAT activities of rice roots of the selected cultivars. MP had no inhabitation or enhancement effects on TSH of rice roots but enhance the contents of MTs and NPT to binding Cd to complete detoxification process. MP as a novel and efficient immobilization agent could complete the remediation effects through soil chemistry and plant physiological mechanisms.

http://ift.tt/2grTC2S

The radiographically diagnosed adrenal myelolipoma: what do we really know?

Abstract

Purpose

Adrenal myelolipomas are uncommon, benign tumors of the adrenal glands that are not routinely evaluated for autonomous hormone secretion or followed by repeat imaging, but may lead to retroperitoneal hemorrhage. Little is known about the natural history these tumors with the majority of previous publications being confined to case reports and small case series.

Methods

We reviewed the computed tomography (CT) reports of 62,279 patients evaluated at a tertiary referral center between 2002 and 2015 for the presence of an adrenal myelolipoma >1 cm in size. We then reviewed the CT imaging and patient charts to determine tumor size, growth, evidence of retroperitoneal hemorrhage, and endocrine dysfunction.

Results

We identified 150 (0.24%) patients with 155 radiographically diagnosed adrenal myelolipomas found on a CT scan during our study period. The median tumor size at discovery was 2.1 cm. Twelve (7.7%) tumors were >6 cm. Sixty-nine (46%) patients had a follow-up CT with a mean time interval between scans of 3.9 years. Eleven tumors (16%) grew over our follow-up period with a median growth rate of 0.16 cm/year. No patient developed a retroperitoneal hemorrhage. Twenty (13%) patients underwent an evaluation for endocrine dysfunction. Three patients had evidence of hypercortisolism and one patient had primary aldosteronism.

Conclusion

The majority of radiographically diagnosed adrenal myelolipomas found on abdominal CT imaging are small and slow growing. Retroperitoneal hemorrhage is uncommon, but the rate of associated endocrine dysfunction may be underestimated.

http://ift.tt/2gxBeZX

Insulin and osteocalcin: further evidence for a mutual cross-talk

Abstract

Purpose

In the last few years, bone has been recognized as an endocrine organ that modulates glucose metabolism by secretion of osteocalcin, an osteoblast-specific hormone, that influences fat deposition and blood sugar levels. To date, however, very few in vitro models have been developed to investigate, at the molecular levels, the relationship between glucose, insulin and osteocalcin. This study aims at covering this gap.

Methods

We studied osteogenic differentiation, osteocalcin gene expression, and osteblast-mediated insulin secretion, using cultured MG-63 human osteoblast-like cells that underwent glucotoxicity and insulin resistance. In addition, we investigated whether a correlation existed between hyperglycemia and/or insulin resistance and total osteocalcin serum concentrations in patients.

Results

While insulin and low glucose increased osteocalcin gene expression, disruption of insulin signaling in MG-63 osteoblasts and high glucose concentration in cell culture medium decreased osteocalcin gene transcription and reduced osteogenic differentiation. Concomitantly, insulin secretion was significantly impaired in rat INS-1 β-cells treated with conditioned medium from insulin resistant MG-63 cells or cells exposed to high glucose concentrations. Also, chronic hyperglycemia, but not insulin resistance, inversely correlated with circulating osteocalcin levels in patients.

Conclusion

Our results further support the existence of an endocrine axis between bone, where osteocalcin is produced, and pancreatic β-cells, and add new insights into the molecular details of this relationship. These findings may contribute to the understanding of osteocalcin regulation and its role in metabolism.

http://ift.tt/2eNrMxV

Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases

Abstract

Objective

The objective of this study was to explore the prognostic value of cancer stem cell markers, namely CD133, NANOG, and NOTCH1, in early stage oral squamous cell carcinoma (OSCC).

Materials and methods

One hundred forty-four patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer. We examined the impact of the immunohistochemical expression of CD133, NANOG, and NOTCH1 in OSCC. Overall survival (OS) curves were calculated using the Kaplan–Meier method. Predictors of outcome were identified using multivariate analysis.

Results

We found that CD133, NANOG, and NOTCH1 were significantly associated with lymph node metastasis, and NOTCH1 was also significantly associated with depth of invasion and locoregional recurrence.

Conclusions

NOTCH1 was identified as an independent prognostic factor for OS.

Clinical relevance

NOTCH1 might prove to be a useful indicator for high-risk patients with occult metastases from early stage OSCC.

http://ift.tt/2vzRWyD

Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement

Abstract

Background

Guidelines discourage the use of systemic corticosteroids for atopic dermatitis but their use remains widespread.

Objective

To reach consensus among an international group of atopic dermatitis experts on the use of systemic corticosteroids for atopic dermatitis.

Methods

A survey consisting of statements accompanied by visual analog scales ranging from "strongly disagree" to "neutral" to "strongly agree" was distributed to the International Eczema Council (IEC). Consensus was reached in agreement on a statement if <30% of respondents marked to the left of "neutral" towards "strongly disagree."

Results

Sixty of 77 (79%) IEC members participated. Consensus was reached on 12 statements, including that systemic corticosteroids should generally be avoided but can be used rarely for severe atopic dermatitis under certain circumstances, including a lack of other treatment options, as a bridge to other systemic therapies or phototherapy, during acute flares in need of immediate relief, in anticipation of a major life event or in the most severe cases. If used, treatment should be limited to short-term. Most respondents agreed that systemic corticosteroids should never be used in children, but consensus was not reached on that statement. The conclusions of our expert group are limited by a dearth of high-quality published evidence. If more stringent consensus criteria were applied (e.g., requiring <20% of respondents marking towards "strongly disagree," consensus would have been reached on fewer statements.

Conclusions

Based on expert opinion from the IEC, routine use of systemic corticosteroids for atopic dermatitis is generally discouraged and should be reserved for special circumstances.

This article is protected by copyright. All rights reserved.

http://ift.tt/2wrOlRT

Laser Nd:YAG to treat primary pilonidal cysts: an alternative treatment

Abstract

A pilonidal cyst is an acquired inflammatory disease that affects young adults. Many treatments have been described, although no clear consensus has been reported. At present, surgical intervention is the first line of treatment. The main problem after treatment is the high recurrence of the pilonidal sinus (PNS).

We treated six patients with clinical PNS in the natal cleft (with different time of evolution) and 1.5 cm diameter approximately with Nd:YAG (1064nm). It took 3-4 treatments to resolve the sinus. It is important to remove the residual hairs into the cyst. All of our patients healed. Six lesions were eradicated, and no symptoms were described after the treatment. The mean follow-up period was 52 months (12 to 100 months) without any recurrences.

The early management of pilonidal cysts, with Nd:YAG (1064nm) could be an interesting way of treatment versus conventional surgery, because it causes few side effects and the clinical and aesthetic results are optimal.

This article is protected by copyright. All rights reserved.

http://ift.tt/2vT9AbM

Sunburn and ambient temperature

Abstract

On days during the summer months when high temperatures are expected, weather forecasters frequently warn about the dangers of UV and high UV indices. It is not surprising, therefore, that it is a common belief that high ambient air temperatures are a major risk factor for burning. Although the UV index is generally higher on cloudless, hot days compared with cloudy, cool days, reliance should not be placed on ambient temperature alone as a guide to the need for sun protection.

This article is protected by copyright. All rights reserved.

http://ift.tt/2wsxej7

Minimally-invasive and targeted therapeutic cell delivery to the skin using microneedle devices

Summary

Background

Translation of cell therapies to the clinic is accompanied by numerous challenges, including controlled and targeted delivery of the cells to their site of action, without compromising cell viability and functionality.

Objectives

To explore the use of hollow microneedle devices (to date only used for the delivery of drugs and vaccines into the skin and for the extraction of biological fluids) to deliver cells into skin in a minimally-invasive, user-friendly and targeted fashion.

Methods

Melanocyte, keratinocyte and mixed epidermal cell suspensions were passed through various types of microneedles and subsequently delivered into the skin.

Results

Cell viability and functionality is maintained after injection through hollow microneedles with a bore size ≥75 μm. Healthy cells are delivered into skin at clinically relevant depths.

Conclusions

Hollow microneedles provide an innovative and minimally-invasive method for delivering functional cells into the skin. Microneedle cell delivery represents a potential new treatment option for cell therapy approaches including skin re-pigmentation, wound repair, scar and burn remodelling, immune therapies, and cancer vaccines.

This article is protected by copyright. All rights reserved.

http://ift.tt/2ws8l7h

Oral mucosa is a useful substrate for detecting autoantibodies of mucous membrane pemphigoid

Abstract

Mucous membrane pemphigoid (MMP) is a rare autoimmune blistering disease targeting various autoantigens, including the C-terminus of collagen XVII (COL17) and laminin332. Bullous pemphigoid (BP) is the most common autoimmune blistering disease, affecting the mucosae in 10-20% of cases. COL17, particularly, the non-collagenous (NC)16A domain is the pathogenic epitope for BP.

This article is protected by copyright. All rights reserved.

http://ift.tt/2vSEt09

Phase-coherence classification: A new wavelet-based method to separate local field potentials into local (in)coherent and volume-conducted components

Publication date: 1 November 2017
Source:Journal of Neuroscience Methods, Volume 291
Author(s): M. von Papen, H. Dafsari, E. Florin, F. Gerick, L. Timmermann, J. Saur
BackgroundLocal field potentials (LFP) reflect the integrated electrophysiological activity of large neuron populations and may thus reflect the dynamics of spatially and functionally different networks.New methodWe introduce the wavelet-based phase-coherence classification (PCC), which separates LFP into volume-conducted, local incoherent and local coherent components. It allows to compute power spectral densities for each component associated with local or remote electrophysiological activity.ResultsWe use synthetic time series to estimate optimal parameters for the application to LFP from within the subthalamic nucleus of eight Parkinson patients. With PCC we identify multiple local tremor clusters and quantify the relative power of local and volume-conducted components. We analyze the electrophysiological response to an apomorphine injection during rest and hold. Here we show medication-induced significant decrease of incoherent activity in the low beta band and increase of coherent activity in the high beta band. On medication significant movement-induced changes occur in the high beta band of the local coherent signal. It increases during isometric hold tasks and decreases during phasic wrist movement.Comparison with existing methodsThe power spectra of local PCC components is compared to bipolar recordings. In contrast to bipolar recordings PCC can distinguish local incoherent and coherent signals. We further compare our results with classification based on the imaginary part of coherency and the weighted phase lag index.ConclusionsThe low and high beta band are more susceptible to medication- and movement-related changes reflected by incoherent and local coherent activity, respectively. PCC components may thus reflect functionally different networks.



http://ift.tt/2eOuKSR

The radiographically diagnosed adrenal myelolipoma: what do we really know?

Abstract

Purpose

Adrenal myelolipomas are uncommon, benign tumors of the adrenal glands that are not routinely evaluated for autonomous hormone secretion or followed by repeat imaging, but may lead to retroperitoneal hemorrhage. Little is known about the natural history these tumors with the majority of previous publications being confined to case reports and small case series.

Methods

We reviewed the computed tomography (CT) reports of 62,279 patients evaluated at a tertiary referral center between 2002 and 2015 for the presence of an adrenal myelolipoma >1 cm in size. We then reviewed the CT imaging and patient charts to determine tumor size, growth, evidence of retroperitoneal hemorrhage, and endocrine dysfunction.

Results

We identified 150 (0.24%) patients with 155 radiographically diagnosed adrenal myelolipomas found on a CT scan during our study period. The median tumor size at discovery was 2.1 cm. Twelve (7.7%) tumors were >6 cm. Sixty-nine (46%) patients had a follow-up CT with a mean time interval between scans of 3.9 years. Eleven tumors (16%) grew over our follow-up period with a median growth rate of 0.16 cm/year. No patient developed a retroperitoneal hemorrhage. Twenty (13%) patients underwent an evaluation for endocrine dysfunction. Three patients had evidence of hypercortisolism and one patient had primary aldosteronism.

Conclusion

The majority of radiographically diagnosed adrenal myelolipomas found on abdominal CT imaging are small and slow growing. Retroperitoneal hemorrhage is uncommon, but the rate of associated endocrine dysfunction may be underestimated.

http://ift.tt/2gxBeZX

Insulin and osteocalcin: further evidence for a mutual cross-talk

Abstract

Purpose

In the last few years, bone has been recognized as an endocrine organ that modulates glucose metabolism by secretion of osteocalcin, an osteoblast-specific hormone, that influences fat deposition and blood sugar levels. To date, however, very few in vitro models have been developed to investigate, at the molecular levels, the relationship between glucose, insulin and osteocalcin. This study aims at covering this gap.

Methods

We studied osteogenic differentiation, osteocalcin gene expression, and osteblast-mediated insulin secretion, using cultured MG-63 human osteoblast-like cells that underwent glucotoxicity and insulin resistance. In addition, we investigated whether a correlation existed between hyperglycemia and/or insulin resistance and total osteocalcin serum concentrations in patients.

Results

While insulin and low glucose increased osteocalcin gene expression, disruption of insulin signaling in MG-63 osteoblasts and high glucose concentration in cell culture medium decreased osteocalcin gene transcription and reduced osteogenic differentiation. Concomitantly, insulin secretion was significantly impaired in rat INS-1 β-cells treated with conditioned medium from insulin resistant MG-63 cells or cells exposed to high glucose concentrations. Also, chronic hyperglycemia, but not insulin resistance, inversely correlated with circulating osteocalcin levels in patients.

Conclusion

Our results further support the existence of an endocrine axis between bone, where osteocalcin is produced, and pancreatic β-cells, and add new insights into the molecular details of this relationship. These findings may contribute to the understanding of osteocalcin regulation and its role in metabolism.

http://ift.tt/2eNrMxV

Contextual Facilitators and Barriers of Community Reintegration among Injured Female Military Veterans: A Qualitative Study

Publication date: Available online 1 September 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Brent L. Hawkins, Brandi M. Crowe
ObjectiveTo understand the facilitators and barriers to community reintegration (CR) among injured female veterans.DesignPhenomenological qualitative designSettingCommunityParticipantsCommunity-dwelling female veterans with physical and/or psychological injury (N=13).InterventionsNoneMain Outcome MeasuresNoneResultsConventional content analysis revealed three types of facilitators, including: (a) strong social supports; (b) impactful programs; and (c) protective personal beliefs. Six types of barriers included: (a) inadequate services; (b) lack of access to services; (c) poor social support; (d) difficulty trusting others; (e) non-supportive personal beliefs; and (f) injury factors.DiscussionMultiple environmental and personal factors acted as facilitators and barriers to CR. Findings are relatively consistent with previous veteran and civilian community reintegration research that indicates the importance of health-related services, attitudes of others, and social support. However, females in this study reported being impacted by many of these facilitators and barriers because of their gender.ConclusionsThis study supports the need to foster social support among injured female veterans throughout the rehabilitation process to promote CR. Long-term social support can be gained by incorporating services such as adjunctive therapies, recreation, and other social programming into the rehabilitation repertoire to help with CR for all veterans, particularly females.



http://ift.tt/2wZETqp