Scholar : Ειδοποίηση Μελετητή - [ ΠΑΛΙΝ

Ειδοποίηση Μελετητή:[ ΠΑΛΙΝΔΡΟΜΗΣΗ ]

ΣΤΑΤΙΣΤΙΚΟΣ ΕΛΕΓΧΟΣ ΦΥΣΙΚΩΝ ΧΗΜΙΚΩΝ ΑΝΑΛΥΣΕΩΝ ΣΤΟ ΕΙΣΚΟΜΙΣΘΕΝ ΓΑΛΑ ΜΙΑΣ ΓΑΛΑΚΤΟΒΙΟΜΗΧΑΝΙΑΣ

Α ΠΑΠΑΜΙΧΑΗΛ - 2017

... Advisor: ΤΣΙΜΗΚΑΣ , ΙΩΑΝΝΗΣ. Keywords: ΚΥΡΙΑ ΣΥΣΤΑΤΙΚΑ ΤΟΥ ΓΑΛΑΚΤΟΣ;MILK'S MAIN
INGREDIENTS;ΑΝΑΛΥΣΗ ΔΕΔΟΜΕΝΩΝ;DATA ANALYSIS;ΠΟΛΛΑΠΛΗ ΠΑΛΙΝΔΡΟΜΗΣΗ;
MULTIPLE REGRESSION;ΜΟΝΤΕΛΟ ΠΡΟΒΛΕΨΗΣ;PREDICTION MODEL. ...

Διερεύνηση της υπόθεσης της περιβαλλοντικής καμπύλης του Kuznets στην περίπτωση των κατασκευαστικών υλικών.

Μ Μπίρμπας - 2017

... κατασκευαστικών υλικών. Authors: Μπίρμπας, Μιλτιάδης. Advisor: Καϊκα , Δήμητρα.
Keywords: περιβαλλοντική καμπύλη Kuznets;απλή γραμμική παλινδρόμηση;
κατασκευαστικά υλικά. Issue Date: 20-Sep-2017. Abstract: Η υπόθεση ...

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Scholar : Ειδοποίηση Μελετητή - [ ΟΓΚΟΛ

Ειδοποίηση Μελετητή:[ ΟΓΚΟΛΟΓΙΑ ]

Διερεύνηση των κλινικών μελετών στην ογκολογία σε δημόσια νοσηλευτικά ιδρύματα της 1ης Υγειονομική Περιφέρεια Αττικής

Δ Μέκρας - 2017

Σκοπός: Σκοπός της παρούσας διπλωματικής εργασίας ήταν η αποτύπωση των
χαρακτηριστικών των κλινικών μελετών στην ογκολογία που διεξάγονταν στα δημόσια
νοσηλευτικά ιδρύματα της 1ης Υγειονομικής Περιφέρειας Αττικής το 2016, και η διερεύνηση

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Scholar : Ειδοποίηση Μελετητή - [ ΧΗΜΕΙ

Ειδοποίηση Μελετητή:[ ΧΗΜΕΙΟΘΕΡΑΠΕΙΑ ]

Διερεύνηση των κλινικών μελετών στην ογκολογία σε δημόσια νοσηλευτικά ιδρύματα της 1ης Υγειονομική Περιφέρεια Αττικής

Δ Μέκρας - 2017

... Σε μεγάλο βαθμό οι έρευνες αφορούσαν ασθενείς με προχωρημένο καρκίνο (77.5%), που είχαν
λάβει προηγηθείσα χημειοθεραπεία (60.4%), ενώ, παράλληλα, χρησιμοποιήθηκαν στοχευμένες
θεραπείες (82.9%) για να αξιολογηθεί κάποιο θεραπευτικό σχήμα (81.5%), με κύριο στόχο ...

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Scholar : Ειδοποίηση Μελετητή - [ ΥΠΟΦΥ

Ειδοποίηση Μελετητή:[ ΥΠΟΦΥΣΗ ΥΠΟΘΑΛΑΜΟΣ ]

[PDF] Ανάπτυξη και υλοποίηση αλγορίθμων ψηφιακής επεξεργασίας σήματος

Ε Ιωαννίδου - 2017

... και θάλαμο, τον υποθάλαμο και την υπόφυση εγκέφαλος και είναι η περιοχή απ' όπου συνδέουν
τον εγκεφαλικό φλοιό με τον ο αισθητηριακά νευρικά ερεθίσματα, που έχο περνούν μέσα από το
θάλαμο, που αποτελ συνέχεια στέλνονται στην παρεγκεφαλίδα υποθάλαμος, βρίσκεται ...

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Scholar : Ειδοποίηση Μελετητή - [ Myringotom

Ειδοποίηση Μελετητή:[ Myringotomy and tubes ]

Simulation in Otolaryngology, An Issue of Otolaryngologic Clinics of North, E-Book

S Malekzadeh - 2017

Clinical Report: Warsaw Breakage Syndrome with small radii and fibulae

S Eppley, RJ Hopkin, B Mendelsohn, AM Slavotinek - … Journal of Medical Genetics Part A

... grade level. She had recurrent episodes of otitis media throughout childhood and
had myringotomy tubes and a cochlear implant for her hearing loss. She developed
pubic hair at age 3 and had menarche at 8 years of age. A ...

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Scholar : Ειδοποίηση Μελετητή - [ ΑΠΝΟΙ

Ειδοποίηση Μελετητή:[ ΑΠΝΟΙΑ ]

[PDF] Καρδιαγγειακός κίνδυνος ατόμων με μεταβολικό σύνδρομο

Θ Χειμώνας - 2017

Page 1. ΠΑΝΕΠΙ΢ΣΗΜΙΟ ΙΩΑΝΝΙΝΩΝ ΢ΦΟΛΗ ΕΠΙ΢ΣΗΜΩΝ ΤΓΕΙΑ΢ ΣΜΗΜΑ ΙΑΣΡΙΚΗ΢ ΣΟΜΕΑ΢
ΠΑΘΟΛΟΓΙΑ΢ ΠΑΘΟΛΟΓΙΚΗ ΚΛΙΝΙΚΗ «Καρδιαγγειακός κίνδυνος ατόμων με μεταβολικό
σύνδρομο» ΦΕΙΜΩΝΑ΢ ΘΕΟΔΩΡΟ΢ ΚΑΡΔΙΟΛΟΓΟ΢ ΔΙΔΑΚΣΟΡΙΚΗ ΔΙΑΣΡΙΒΗ ...

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Scholar : Ειδοποίηση Μελετητή - [ ΑΛΛΕΡ

Ειδοποίηση Μελετητή:[ ΑΛΛΕΡΓΙΑ ]

[PDF] Οι αλλαγές στον χαρακτήρα του «κακού» λύκου στα σύγχρονα παραμύθια και οι ιδεολογικές διαστάσεις τους

Χ Αποστολίδου, Β Ζυγερίδου, C Apostilidou… - 2017

Page 1. ΔΗΜΟΚΡΙΤΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΡΑΚΗΣ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΑΓΩΓΗΣ
ΠΑΙΔΑΓΩΓΙΚΟ ΤΜΗΜΑ ΔΗΜΟΤΙΚΗΣ ΕΚΠΑΙΔΕΥΣΗΣ ΤΟΜΕΑΣ ΑΝΘΡΩΠΙΣΤΙΚΩΝ ΚΑΙ
ΚΟΙΝΩΝΙΚΩΝ ΕΠΙΣΤΗΜΩΝ "Οι αλλαγές στον χαρακτήρα του «κακού» λύκου στα ...

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Scholar : Ειδοποίηση Μελετητή - [ ΑΚΟΗ ]

Ειδοποίηση Μελετητή:[ ΑΚΟΗ ]

[PDF] Ανάπτυξη και υλοποίηση αλγορίθμων ψηφιακής επεξεργασίας σήματος

Ε Ιωαννίδου - 2017

Page 1. ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚ ΣΧΟΛΗ ΔΙΟΙΚΗΣΗΣ ΤΜΗΜΑ ΠΛΗΡΟΦ
ΠΤΥΧΙΑΚΗ Ε ΑΝΑΠΤΥΞΗ ΚΑΙ ΥΛΟΠΟΙΗΣ ΨΗΦΙΑΚΗΣ ΕΠΕΞΕΡΓΑΣΙ ΕΦΑΡΜΟΓΗ
ΣΤΗΝ ΑΝΑΛΥ ΕΓΚΕΦΑΛΟ ΕΙ ΕΠΟΠΤΕΥΩΝ ΚΑΘΗΓΗΤΗ i ΓΙΚΟ ...

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Scholar : Ειδοποίηση Μελετητή - [ intitle:Bi

Ειδοποίηση Μελετητή:[ intitle:Bioprinting ]

Characterisation of Hyaluronic Acid Methylcellulose Hydrogels for 3D Bioprinting

N Law, B Doney, H Glover, Y Qin, ZM Aman… - Journal of the Mechanical …, 2017

Abstract Hydrogels containing hyaluronic acid (HA) and methylcellulose (MC) have shown
promising results for three dimensional (3D) bioprinting applications. However, several
parameters influence the applicability bioprinting and there is scarce data in the literature

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Is Load-Induced Ventricular Hypertrophy Ever Compensatory?.

Author: Schiattarella, Gabriele G. MD; Hill, Theodore M.; Hill, Joseph A. MD, PhD

Page: 1273-1275

http://ift.tt/2fFmV1J

Subclinical Atrial Fibrillation in Older Patients.

Author: Healey, Jeff S. MD, MSc; Alings, Marco MD; Ha, Andrew MD; Leong-Sit, Peter MD; Birnie, David H. MD; de Graaf, Jacob J. MD; Freericks, Michel MD; Verma, Atul MD; Wang, Jia PhD; Leong, Darryl MD; Dokainish, Hisham MD; Philippon, Francois MD; Barake, Walid MD; McIntyre, William F. MD; Simek, Kim BSc; Hill, Michael D. MD; Mehta, Shamir R. MD, MSc; Carlson, Mark MD; Smeele, Frank MD; Pandey, A. Shekhar MD; Connolly, Stuart J. MD; on behalf of the ASSERT-II Investigators

Page: 1276-1283

http://ift.tt/2xbBq8S

Seek and Ye Shall Find Subclinical Atrial Fibrillation in High-Risk Elderly Patients.

Author: Wijesurendra, Rohan S. MA, MRCP; Casadei, Barbara MD, DPhil, FRCP, FMedSci

Page: 1284-1287

http://ift.tt/2fFn0m3

Dynamic Edematous Response of the Human Heart to Myocardial Infarction: Implications for Assessing Myocardial Area at Risk and Salvage.

Author: Fernandez-Jimenez, Rodrigo MD *; Barreiro-Perez, Manuel MD, PhD *; Martin-Garcia, Ana MD, PhD *; Sanchez-Gonzalez, Javier PhD; Aguero, Jaume MD, PhD; Galan-Arriola, Carlos DVM; Garcia-Prieto, Jaime BSc; Diaz-Pelaez, Elena MD; Vara, Pedro DCS; Martinez, Irene DCS; Zamarro, Ivan DCS; Garde, Beatriz BPharm; Sanz, Javier MD; Fuster, Valentin MD PhD; Sanchez, Pedro L. MD, PhD; Ibanez, Borja MD, PhD

Page: 1288-1300

http://ift.tt/2xbnX0X

Time-Varying Edema Requires Cautious Interpretation of Myocardium at Risk and Infarct Size by All Imaging Methods.

Author: Arai, Andrew E. MD

Page: 1301-1303

http://ift.tt/2fHmkwt

Randomized Comparison of Ridaforolimus- and Zotarolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease: Primary Results From the BIONICS Trial (BioNIR Ridaforolimus-Eluting Coronary Stent System in Coronary Stenosis).

Author: Kandzari, David E. MD; Smits, Pieter C. MD; Love, Michael P. MD; Ben-Yehuda, Ori MD; Banai, Shmuel MD; Robinson, Simon D. MD; Jonas, Michael MD; Kornowski, Ran MD; Bagur, Rodrigo MD, PhD; Iniguez, Andres MD, PhD; Danenberg, Haim MD; Feldman, Robert MD; Jauhar, Rajiv MD; Chandna, Harish MD; Parikh, Manish MD; Perlman, Gidon Y. MD, MSc; Balcells, Mercedes PhD; Markham, Peter MSc; Ozan, Melek Ozgu MSc; Genereux, Philippe MD; Edelman, Elazer R. MD, PhD; Leon, Martin B. MD; Stone, Gregg W. MD

Page: 1304-1314

http://ift.tt/2xbnVWT

Kruppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility.

Author: Li, Zhao BS *; Martin, Marcy BS *; Zhang, Jin BS; Huang, Hsi-Yuan PhD; Bai, Liang PhD; Zhang, Jiao MD; Kang, Jian PhD; He, Ming MD, PhD; Li, Jie BS; Maurya, Mano R. PhD; Gupta, Shakti PhD; Zhou, Guangjin PhD; Sangwung, Panjamaporn PhD; Xu, Yong-Jiang PhD; Lei, Ting PhD; Huang, Hsien-Da PhD; Jain, Mohit MD; Jain, Mukesh K. MD; Subramaniam, Shankar PhD; Shyy, John Y.-J. PhD

Page: 1315-1330

http://ift.tt/2fFwiys

Current Practice of State-of-the-Art Surgical Coronary Revascularization.

Author: Head, Stuart J. MD, PhD; Milojevic, Milan MD, MSc; Taggart, David P. MD, PhD; Puskas, John D. MD

Page: 1331-1345

http://ift.tt/2xbnVpR

Hypoplastic Left Heart Syndrome With Intact or Restrictive Atrial Septum: A Report From the International Fetal Cardiac Intervention Registry.

Author: Jantzen, David W. MD; Moon-Grady, Anita J. MD; Morris, Shaine A. MD, MPH; Armstrong, Aimee K. MD; Berg, Christoph MD; Dangel, Joanna MD, PhD; Fifer, Carlen G. MD; Frommelt, Michele MD; Gembruch, Ulrich MD; Herberg, Ulrike MD; Jaeggi, Edgar MD; Kontopoulos, Eftichia V. MD, PhD; Marshall, Audrey C. MD; Miller, Owen; Oberhoffer, Renate MD, PhD; Oepkes, Dick MD, PhD; Pedra, Carlos A. MD, PhD; Pedra, Simone R. MD, PhD; Peralta, Fabio MD; Quintero, Ruben A. MD; Ryan, Greg MB; Gelehrter, Sarah K. MD

Page: 1346-1349

http://ift.tt/2fFmKU7

Importance of Routine Antihuman/Leukocyte Antibody Monitoring: De Novo Donor Specific Antibodies Are Associated With Rejection and Allograft Vasculopathy After Heart Transplantation.

Author: Wong, Ka L. MBBS; Taner, Timucin MD, PhD; Smith, Byron H. PhD; Kushwaha, Sudhir S. MD; Edwards, Brooks S. MD; Gandhi, Manish J. MD; Kremers, Walter K. PhD; Daly, Richard C. MD; Pereira, Naveen L. MD

Page: 1350-1352

http://ift.tt/2xbnUSP

Letter by Ma et al Regarding Article, "Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction: Insights From the TRIUMPH Registry (Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status)".

Author: Ma, Lei-Lei MD; Kong, Fei-Juan MD; Ge, Jun-Bo MD

Page: 1353-1354

http://ift.tt/2fFmJ2v

Response by Smolderen et al to Letter Regarding Article, "Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction: Insights From the TRIUMPH Registry (Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status)".

Author: Smolderen, Kim G. E.; Gosch, Kensey G.; Buchanan, Donna M.; Spertus, John A.

Page: 1355-1356

http://ift.tt/2xbBllA

Letter by Fukunaga and Rao Regarding Article, "Transcatheter Treatment of Severe Tricuspid Regurgitation With the Edge-to-Edge MitraClip Technique".

Author: Fukunaga, Naoto MD; Rao, Vivek MD, PhD

Page: 1357-1358

http://ift.tt/2fEAjn0

Should We Stop Thinking About Inhibition? Searching for Individual and Age Differences in Inhibition Ability.

Author: Rey-Mermet, Alodie; Gade, Miriam; Oberauer, Klaus

DOI: 10.1037/xlm0000450

Publication Date: POST AUTHOR CORRECTIONS, 28 September 2017

http://ift.tt/2xU3HzE

Morphological Effects in Visual Word Recognition: Children, Adolescents, and Adults.

Author: Dawson, Nicola; Rastle, Kathleen; Ricketts, Jessie

DOI: 10.1037/xlm0000485

Publication Date: POST AUTHOR CORRECTIONS, 28 September 2017

http://ift.tt/2xOliHj

The dichotomy between low frequency and delta waves in human sleep: A reappraisal

Publication date: Available online 2 October 2017
Source:Journal of Neuroscience Methods
Author(s): Jean-Pol Lanquart, Pasquale Nardone, Philippe Hubain, Gwénolé Loas, Paul Linkowski
BackgroundWe present the results of an analysis of the low frequency (LF) (0.25–1Hz) and delta (1–4Hz) waves during human sleep. Our objective was to investigate whether LF and delta waves should be considered as separate entities.MethodsThe slow-wave electroencephalogram (EEG) activity of 2 sets of 10 young, healthy volunteers was analysed utilising the rarely-used Lomb-Scargle periodogram. This method has advantages over the more commonly-used Fast Fourier Transform analysis.ResultsDuring the night, the frequencies of the most powerful waves are concentrated in the 0.5–2Hz range and show a continuous tendency to shift towards slower frequencies during sleep.Comparison with existing methodsWhen considering the frequency dynamics of slow-wave activity below 3Hz, the unifying theory of LF and delta waves is more parsimonious than the idea that there is a different origin and regulation for the two sub-bands.ConclusionsThe unifying theory of LF and delta waves is the simplest explanation for the slow-wave activity of the EEG below 3Hz. This finding is important for the clinical use of slow-wave activity.



http://ift.tt/2xTLFNV

Food addiction and substance addiction in women: Common clinical characteristics

Publication date: 1 January 2018
Source:Appetite, Volume 120
Author(s): Raven Hardy, Negar Fani, Tanja Jovanovic, Vasiliki Michopoulos
Food addiction is characterized by poorly controlled intake of highly-palatable, calorically-dense, foods. While previous studies indicate that risk factors for food addiction are similar to substance use disorders (SUD), these studies have looked at food addiction and SUD in independent samples, limiting the ability to directly compare food addiction to SUD. The present study was conducted to assess rates of posttraumatic stress disorder (PTSD), depression, childhood and adult trauma exposure, as well as presence and severity of emotion dysregulation, in a sample of women (N = 229) who either meet criteria for no addiction, food addiction only or SUD only. The prevalence of food addiction was 18.3% and the prevalence of SUD was 30.6% in this sample. Women with food addiction and women with SUD endorsed more depression and PTSD symptoms when compared with individuals with no addiction. Individuals with food addiction and SUD had higher total emotion dysregulation scores, specifically with difficulties in goal directed behaviors, non-acceptance of emotional responses, impulse control, limited access to emotion regulation strategies, and lack of emotional clarity, when compared to individuals with no addiction (all p's < 0.05). There were no differences in PTSD and depression symptoms and emotion dysregulation scores between food addiction and SUD groups (all p > 0.05). However, women with SUD endorsed higher levels of total childhood (p < 0.01) and adulthood trauma (p < 0.01) as compared with women with no addiction or food addiction. These results suggest that women with food addiction and those with SUD share similar psychological characteristics and risk factors, with the exception of trauma histories. These findings have implications for the detection of risk for and treatment of these disorders.



http://ift.tt/2xXzPTe

Association between high risk for preterm birth and changes in gingiva parameters during pregnancy—a prospective cohort study

Abstract

Objectives

The objective of this study was to investigate clinical and microbiological gingival changes during pregnancy in women without periodontal disease. Additionally, these parameters were to be compared in women with high risk for preterm birth and women with a normal course of pregnancy.

Method and materials

Group I consisted of 40 subjects at high risk for preterm birth, while group II involved 49 subjects with a normal course of pregnancy. The control group (III) was made up of 50 non-pregnant women. Clinical parameters (plaque index, gingival index, probing pocket depths, gingival swelling, bleeding on probing) and microbiological changes were monitored during pregnancy and 2–4 weeks after parturition.

Results

In the high-risk preterm group (I), 19 women could be included in data analysis. This group was compared to 41 women in the normal pregnancy group (II) and 50 non-pregnant women (III). Gingival inflammation was significantly higher in women with high risk for preterm birth (I) compared to non-risk pregnant women (II, p < 0.05). In addition, in this group (I), the subgingival amounts of Fusobacterium nucleatum (> 10⁵) were found to be significantly higher after childbirth compared to non-pregnant women (p < 0.05).

Conclusions

Even without having periodontal disease, women with high risk for preterm birth showed worse clinical values compared to non-risk pregnant and non-pregnant women and an increased detection of Fusobacterium nucleatum after delivery.

Clinical relevance

High risk for preterm birth might be associated with the occurrence of increased gingival inflammation.

http://ift.tt/2yEeY4r

Performance and Interpretation Training of Transthoracic Echocardiography in Resource-Limited Settings

http://ift.tt/2xbPgmN

The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study

AbstractBackground

Daily habits, including the number and quality of eating occasions, are potential targets for primary prevention strategies with large health impacts. Skipping breakfast is considered a frequent and unhealthy habit associated with an increased cardiovascular (CV) risk.

Objectives

The study sought to explore the association between different breakfast patterns and CV risk factors and the presence, distribution, and extension of subclinical atherosclerosis.

Methods

Cross-sectional analysis was performed within the PESA (Progression of Early Subclinical Atherosclerosis) study, a prospective cohort of asymptomatic (free of CV events at baseline) adults 40 to 54 years of age. Lifestyle and multivascular imaging data along with clinical covariates were collected from 4,052 participants. Multivariate logistic regression models were used in the analysis.

Results

Three patterns of breakfast consumption were studied: high-energy breakfast, when contributing to >20% of total daily energy intake (27% of the population); low-energy breakfast, when contributing between 5% and 20% of total daily energy intake (70% of the population); and skipping breakfast, when consuming <5% of total daily energy (3% of the population). Independent of the presence of traditional and dietary CV risk factors, and compared with high-energy breakfast, habitual skipping breakfast was associated with a higher prevalence of noncoronary (odds ratio: 1.55; 95% confidence interval: 0.97 to 2.46) and generalized (odds ratio: 2.57; 95% confidence interval: 1.54 to 4.31) atherosclerosis.

Conclusion

Skipping breakfast is associated with an increased odds of prevalent noncoronary and generalized atherosclerosis independently of the presence of conventional CV risk factors. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318)

http://ift.tt/2xaG5rB

Sports Cardiology: Core Curriculum for Providing Cardiovascular Care to Competitive Athletes and Highly Active People

Abstract

The last few decades have seen substantial growth in the populations of competitive athletes and highly active people (CAHAP). Although vigorous physical exercise is an effective way to reduce the risk of cardiovascular (CV) disease, CAHAP remain susceptible to inherited and acquired CV disease, and may be most at risk for adverse CV outcomes during intense physical activity. Traditionally, multidisciplinary teams comprising athletic trainers, physical therapists, primary care sports medicine physicians, and orthopedic surgeons have provided clinical care for CAHAP. However, there is increasing recognition that a care team including qualified CV specialists optimizes care delivery for CAHAP. In recognition of the increasing demand for CV specialists competent in the care of CAHAP, the American College of Cardiology has recently established a Sports and Exercise Council. An important primary objective of this council is to define the essential skills necessary to practice effective sports cardiology.

http://ift.tt/2xaAeT7

Hearty Breakfast for Healthier Arteries

http://ift.tt/2xbXJWY

Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance

http://ift.tt/2xaKDOJ

Characterization of the Average Daily Ischemic and Bleeding Risk After Primary PCI for STEMI

AbstractBackground

The risk of recurrent ischemic and bleeding events after primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) may not be uniform over time, which may affect the benefit-to-risk ratio of guideline-recommended antithrombotic therapies in different intervals.

Objectives

This study sought to characterize the average daily ischemic rates (ADIRs) and average daily bleeding rates (ADBRs) within the first year after primary PCI for STEMI.

Methods

Among 3,602 patients with STEMI who were enrolled in the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial, all ischemic and bleeding events, including recurrent events, were classified according to the timing of their occurrence as acute (≤24 h after PCI), subacute (1 day to 30 days), and late (30 days to 1 year). Patients were treated with aspirin and clopidogrel for the entire year. ADIRs included cardiac death, reinfarction, and definite stent thrombosis. ADBRs included non–coronary artery bypass graft–related Thrombolysis In Myocardial Infarction major and minor bleeding. ADIRs and ADBRs were calculated as the total number of events divided by the number of patient-days of follow-up in each interval assuming a Poisson distribution. Generalized estimating equations were used to test the absolute least square mean differences (LSMD) between ADIRs and ADBRs.

Results

The ADIR and ADBR both exponentially decreased from the acute to the late periods (p < 0.0001). Although there were no significant differences in ADIR and ADBR in the acute phase (LSMD: +0.11%; 95% confidence interval [CI]: –0.35% to 0.58%; p = 0.63), the ADBR was greater than the ADIR in the subacute phase (LSMD: –0.39%; 95% CI: –0.58% to –0.20%; p < 0.0001). In the late phase, the ADIR exceeded the ADBR (LSMD: +1.51%; 95% CI: 1.04% to 1.98%; p < 0.0001).

Conclusions

After primary PCI, the ADIR and ADBR both markedly decreased over time. Although the rates for bleeding exceeded those for ischemia within 30 days, the daily risk of ischemia significantly exceeded the daily risk of bleeding beyond 30 days, supporting the use of intensified platelet inhibition during the first year after STEMI.

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The Hospital Readmission Reduction Program Is Associated With Fewer Readmissions, More Deaths: Time to Reconsider

http://ift.tt/2xcGn1j

Predicting Risk in ACS: Taking the Long-Term View

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Preterm Birth and Risk of Heart Failure Up to Early Adulthood

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Heart Rate and Outcomes in Hospitalized Patients With Heart Failure With Preserved Ejection Fraction

AbstractBackground

A lower heart rate is associated with better outcomes in patients with heart failure (HF) with reduced ejection fraction (EF). Less is known about this association in patients with HF with preserved ejection fraction (HFpEF).

Objectives

The aims of this study were to examine associations of discharge heart rate with outcomes in hospitalized patients with HFpEF.

Methods

Of the 8,873 hospitalized patients with HFpEF (EF ≥50%) in the Medicare-linked OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) registry, 6,286 had a stable heart rate, defined as ≤20 beats/min variation between admission and discharge. Of these, 2,369 (38%) had a discharge heart rate of <70 beats/min. Propensity scores for discharge heart rate <70 beats/min, estimated for each of the 6,286 patients, were used to assemble a cohort of 2,031 pairs of patients with heart rate <70 versus ≥70 beats/min, balanced on 58 baseline characteristics.

Results

The 4,062 matched patients had a mean age of 79 ± 10 years, 66% were women, and 10% were African American. During 6 years (median 2.8 years) of follow-up, all-cause mortality was 65% versus 70% for matched patients with a discharge heart rate <70 versus ≥70 beats/min, respectively (hazard ratio [HR]: 0.86; 95% confidence interval [CI]: 0.80 to 0.93; p < 0.001). A heart rate <70 beats/min was also associated with a lower risk for the combined endpoint of HF readmission or all-cause mortality (HR: 0.90; 95% CI: 0.84 to 0.96; p = 0.002), but not with HF readmission (HR: 0.93; 95% CI: 0.85 to 1.01) or all-cause readmission (HR: 1.01; 95% CI: 0.95 to 1.08). Similar associations were observed regardless of heart rhythm or receipt of beta-blockers.

Conclusions

Among hospitalized patients with HFpEF, a lower discharge heart rate was independently associated with a lower risk of all-cause mortality, but not readmission.

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JACC Instructions for Authors

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Limitations of Treating Heart Rate as the Primary Outcome Determinant in Older Adults

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Palliative Care in Heart Failure: Rationale, Evidence, and Future Priorities

Abstract

Patients with heart failure (HF) and their families experience stress and suffering from a variety of sources over the course of the HF experience. Palliative care is an interdisciplinary service and an overall approach to care that improves quality of life and alleviates suffering for those living with serious illness, regardless of prognosis. In this review, we synthesize the evidence from randomized clinical trials of palliative care interventions in HF. While the evidence base for palliative care in HF is promising, it is still in its infancy and requires additional high-quality, methodologically sound studies to clearly elucidate the role of palliative care for patients and families living with the burdens of HF. Yet, an increase in attention to primary palliative care (e.g., basic physical and emotional symptom management, advance care planning), provided by primary care and cardiology clinicians, may be a vehicle to address unmet palliative needs earlier and throughout the illness course.

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Pulmonary Artery Pressure-Guided Management of Patients With Heart Failure and Reduced Ejection Fraction

AbstractBackground

Despite increased use of guideline-directed medical therapy (GDMT), some patients with heart failure and reduced ejection fraction (HFrEF) remain at high risk for hospitalization and mortality. Remote monitoring of pulmonary artery (PA) pressures provides clinicians with actionable information to help further optimize medications and improve outcomes.

Objectives

CHAMPION (CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Patients trial) analyzed PA pressure-guided heart failure (HF) management in patients with HFrEF based on their ability to tolerate GDMT.

Methods

CHAMPION enrolled 550 patients with chronic HF regardless of left ventricular ejection fraction. A pre-specified sub-group analysis compared HF hospitalization and mortality rates between treatment and control groups in HFrEF patients (left ventricular ejection fraction ≤40%). Post hoc analyses in patients who tolerated GDMT were also performed. Hospitalizations and mortality were assessed using Andersen-Gill and Cox proportional hazards models.

Results

In 456 patients with HFrEF, HF hospitalization rates were 28% lower in the treatment group than in the control group (hazard ratio [HR]: 0.72; 95% confidence interval [CI]: 0.59 to 0.88; p = 0.0013), with a strong trend for 32% lower mortality (HR: 0.68; 95% CI: 0.45 to 1.02; p = 0.06). A 445-patient subset received at least 1 GDMT (angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, or beta-blocker) at baseline; these patients had 33% lower HF hospitalization rates (HR: 0.67; 95% CI: 0.54 to 0.82; p = 0.0002) and 47% lower mortality (HR: 0.63; 95% CI: 0.41 to 0.96, p = 0.0293) than controls. Compared with controls, patients receiving both components of optimal GDMT (n = 337) had 43% lower HF hospitalizations (HR: 0.57; 95% CI: 0.45 to 0.74; p < 0.0001) and 57% lower mortality (HR: 0.43; 95% CI: 0.24 to 0.76; p = 0.0026).

Conclusions

PA pressure-guided HF management reduces morbidity and mortality in patients with HFrEF on GDMT, underscoring the important synergy of addressing hemodynamic and neurohormonal targets of HF therapy. (CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Patients [CHAMPION]; NCT00531661)

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Innovating Toward High-Value Cardiovascular Care

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(Re)Discovering the Neurohormonal and Hemodynamic Duality of Heart Failure

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Submaximal Blood Pressure Responses to Exercise in Young Adulthood and Long-Term Cardiovascular Health

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Clinical Outcomes Following the Ross Procedure in Adults: A 25-Year Longitudinal Study

AbstractBackground

Very few reports of long-term outcomes of patients who underwent the Ross procedure have been published.

Objectives

The authors reviewed their 25-year experience with the Ross procedure with the aim of defining very–long-term survival and factors associated with Ross-related failure.

Methods

Between January 1990 and December 2014, the Ross procedure was performed in 310 adults (mean age 40.8 years) at a single institution. All patients were prospectively added to a dedicated cardiac surgery registry. Complete post-operative clinical examination and history were obtained, and transthoracic echocardiography was performed according to a standardized protocol. There was no loss to follow-up. Median follow-up was 15.1 years and up to 25 years.

Results

Bicuspid aortic valve was diagnosed in 227 patients (73.2%), and the most common indication for surgery was aortic stenosis (n = 225 [72.6%]). Freedom from any Ross-related reintervention was 92.9% and 70.1% at 10 and 20 years, respectively. Independent risk factors for pulmonary autograft degeneration were pre-operative large aortic annulus (hazard ratio: 1.1; p = 0.01), pre-operative aortic insufficiency (hazard ratio: 2.7; p = 0.002), and concomitant replacement of the ascending aorta (hazard ratio: 7.7; p = 0.0003). There were 4 hospital deaths (1.3%), and overall survival at 10 and 20 years was 94.1% and 83.6%, respectively. Long-term survival was not significantly different in patients who required Ross-related reintervention (log-rank p = 0.70). However, compared with the general population, survival was significantly lower in patients following the Ross procedure when matched on age and sex (p < 0.0001).

Conclusions

The Ross procedure was associated with excellent long-term valvular outcomes and survival, regardless of the need for reintervention. Adults presenting with aortic insufficiency or a dilated aortic annulus or ascending aorta were at greater risk for reintervention. Unlike previous reports, long-term survival was lower in Ross patients compared with matched subjects.

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Reply: Preterm Birth and Risk of Heart Failure in Childhood and Early Adulthood

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The Ross Outlasts its Critics and Competition

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The prospective evaluation of risk factors and clinical influence of carbapenem resistance in children with gram-negative bacteria infection

Publication date: Available online 2 October 2017
Source:American Journal of Infection Control
Author(s): Zumrut Sahbudak Bal, Nur Bekmezci, Mehmet Soylu, Semra Sen, Gulhadiye Avcu, Sohret Aydemir, Fadil Vardar
BackgroundCarbapenem-resistant gram-negative (CRGN) infections have been increasing in recent years and associated with significant morbidity, mortality, and health care costs. The aim of this study was to evaluate the epidemiologic and clinical risk characteristics, risk factors, and outcome of CRGN infections and to compare with carbapenem-sensitive gram-negative (CSGN) infections in children.MethodsNewly diagnosed CRGN infections in hospitalized children younger than age 18 years were prospectively recorded and all patients infected with a CSGN pathogen in the same unit within 48 hours of diagnosis were included in a control group between April 1, 2014, and December 31, 2014.ResultsTwenty-seven patients with CRGN infections and 28 patients with CSGN infections were enrolled in this study. Ventilator-associated pneumonia was the most common type of infection in both groups. Prior exposure to carbapenems (relative risk [RR], 11.368; 95% confidence interval [CI], 1.311-98.589), prolonged hospitalization (RR, 5.100; 95% CI, 1.601-16.242) were found to be independent risk factors for acquiring CRGN infections. Septic shock was significantly more frequent in the CRGN group (RR, 9.450; 95% CI, 1.075-83.065). The in-hospital mortality was higher in the CRGN group (RR, 7.647; 95% CI, 1.488-39.290).ConclusionsPrior carbapenem exposure and prolonged hospitalization are the most important risk factors for acquiring CRGN infections in our hospital. This study demonstrated, similar to previous reports, that carbapenem resistance increases morbidity, mortality, and health care costs.



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Nurse-driven protocols and the prevention of catheter-associated urinary tract infections: A systematic review

Publication date: Available online 2 October 2017
Source:American Journal of Infection Control
Author(s): Danielle J. Durant
BackgroundCatheter-associated urinary tract infections (CAUTIs) are one of the most common hospital-acquired conditions and no longer reimbursable from Medicare as of 2008. Nurse-driven protocols (NDPs), which provide a medically approved rubric for professional nurses to make autonomous care decisions, can facilitate appropriate catheter use and timely removal, as advised in the Centers for Disease Control and Prevention's 2009 CAUTI prevention guidelines. However, little attempt has been made to systematically evaluate their effect on clinical outcomes.MethodsA systematic review of studies published in the United States since 2006 was performed, following guidelines from the Institute of Medicine. Sources included CINAHL, Medline, professional agencies, hand-searching, and expert consultation. Clinical predictors and prevalence of CAUTI were examined and synthesized qualitatively; heterogeneity of outcomes made a statistical meta-analysis inappropriate.ResultsTwenty-nine studies were found eligible for inclusion. All used a case-control (pre-post) approach, and all reported reductions in clinical predictors of CAUTI, particularly indwelling-urinary catheter utilization and CAUTI rates. However, the number of CAUTIs remained unchanged in 1 study. A formal quality assessment revealed a high risk of bias; included studies met an average of 4.9 out of 11 quality indicators. Specifically, many did not use standardized measures.ConclusionsNDPs appear to have a positive impact on the clinical predictors and prevalence of CAUTI. However, this review identified need for improving the study design of quality improvement projects conducted within the patient care setting.



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The effect of reducing the incidence of gastrointestinal complications in patients treated with aspirin, referred to Imam Hospital, of Ahvaz, Iran

Publication date: Available online 2 October 2017
Source:Data in Brief
Author(s): Abdalrahim Masjedizade, Mohammad Javad Mohammadi, Saeed Yazdankhah, Atefeh Roumi, Arman Shahriari, Sahar Geravandi
This research contains data which were obtained during the analysis of treated patients with aspirin who were referred to Imam Hospital (Imam H) of Ahvaz, Iran; and the effect of this type of treatment (Helicobacter pylori eradicate (HPE)) on reducing the incidence of gastrointestinal complications. Studies have shown that taking aspirin in patients with Helicobacter pylori infection is associated with a decreasing risk of gastrointestinal bleeding (O'connor et al., 2013) [1]. In this study, 165 patients with positive helicobacter pylori infection test were chosen among those who were referred to Imam H. In this paper, the effects of sex, smoking, renal failer, diabetes, age, blood pressure and aspirin consumption have been studied (Lai et al., 2002) [1]. After completion of the observations and records of patient's medical records, the obtained coded data were fed into EXCELL. Data analysis was performed, using SPSS 16.



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Practice variation amongst preventive child healthcare professionals in the prevention of child maltreatment in the Netherlands: qualitative and quantitative data

Publication date: Available online 2 October 2017
Source:Data in Brief
Author(s): Simeon J.A. Visscher, Henk F. van Stel
This article provides both qualitative and quantitative data on practice variation amongst preventive child healthcare professionals in the prevention of child maltreatment in the Netherlands. Qualitative data consist of topics identified during interviews with 11 experts (with quotes), resulting in an online survey. The quantitative data are survey responses from 1104 doctors and nurses working in 29 preventive child healthcare organizations. Additionally, the interview topic list, the qualitative data analysis methodology, the survey (in English and Dutch) and anonymized raw survey data (http://ift.tt/2xPsSl5) are provided as well. This data-in-brief article accompanies the paper "Variation in prevention of child maltreatment by Dutch child healthcare professionals" by Simeon Visscher and Henk van Stel [1].



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Gel-based and gel-free proteome data associated with controlled deterioration treatment of Glycine max seeds

Publication date: Available online 2 October 2017
Source:Data in Brief
Author(s): Cheol Woo Min, Seo Hyun Lee, Ye Eun Cheon, Won Young Han, Jong Min Ko, Hang Won Kang, Yong Chul Kim, Ganesh Kumar Agrawal, Randeep Rakwal, Ravi Gupta, Sun Tae Kim
Data presented are associated with the article: "In-depth proteomic analysis of soybean (Glycine max) seeds during controlled deterioration treatment (CDT) reveals a shift in seed metabolism" [1]. Seed deterioration is one of the major problems, affecting the seed quality, viability, and vigor in a negative manner. Here, we display the gel-based and gel-free proteomic data, associated with the CDT in soybean seeds. The present data was obtained from 2-DE, shotgun proteomic analysis (label-free quantitative proteomic analysis) using Q-Exactive, and gene ontology data associated with CDT in soybean seeds [1].



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Sediment textural characteristics and Elemental distribution in the core sediments, Pullivasal and Kurusadai Island, Gulf of Mannar, Southeast coast of India

Publication date: Available online 2 October 2017
Source:Data in Brief
Author(s): P. Saravanan, S. Krishnakumar©, P. Parthasarathy, Judith D Silva, D. Pradhap
Two core samples were collected in order to assess the textual characteristics and elemental distribution of the sediments, from the lagoonal environment of Pullivasal and Kurusadai island, Gulf of Mannar, Southeast coast of India. The distribution of the organic matter and calcium carbonate is chiefly controlled by the coral debris, shell fragments and mangrove litters. The elemental distribution is controlled by natural process and other trace elements are controlled by anthropogenic land based activities.



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Data on peptides identified by mass spectrometry analysis of in vitro DYRK1A-mediated phosphorylation sites on GLI1

Publication date: Available online 2 October 2017
Source:Data in Brief
Author(s): Ben K. Ehe, David R. Lamson, Michael Tarpley, Rob U. Onyenwoke, Lee M. Graves, Kevin P. Williams
The data presented in this article supports the accompanying research article "Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1" (Ehe et al., 2017) [1]. Although it has been demonstrated that DYRK1A (dual-specificity tyrosine-regulated kinase 1A) can phosphorylate the hedgehog pathway transcription factor GLI1 (GLIoma-associated oncogene homolog 1) the exact DYRK1A-mediated sites of phosphorylation on GLI1 were unknown. This article details the mass spectrometry methods and resulting dataset for the peptides identified from GLI1 when incubated with DYRK1A under varying conditions. The data includes details of sequence coverage and all phospho-peptides identified.



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Supplementary data for the mechanism for cleavage of three typical glucosidic bonds induced by hydroxyl free radical

Publication date: Available online 2 October 2017
Source:Data in Brief
Author(s): Yujie Dai, Chunfu Shao, Yingai Piao, Huiqian Hu, Kui Lu, Tongcun Zhang, Xiuli Zhang, Shiru Jia, Min Wang, Shuli Man
The data presented in this article are related to the research article entitled "The mechanism for cleavage of three typical glucosidic bonds induced by hydroxyl free radical" (Y. Dai, C. Shao, Y. Piao, H. Hu, K. Lu, T. Zhang, X. Zhang, S. Jia, M. Wang, S. Man, 2017) [1]. This article includes the structures of three kinds of disaccharides such as maltose, fructose and cellobiose, the diagrammatic sketch of the hydrogen abstraction reaction of the disaccharides by hydroxyl radical, the structure of the transition states for pyran ring opening of moiety A and cleavage of α(1→2) glycosidic bond starting from the hydrogen abstraction of C6–H in moiety A of sucrose, the transition state structure for cleavage of α(1→2) glycosidic bond starting from the hydrogen abstraction of C1'-H in moiety B of sucrose, the transition state structure, sketch for the reaction process and relative energy change of the reaction pathway for direct cleavage of α(1→4) glycosidic bond starting from hydrogen abstraction of C6'–H of moiety B of maltose.



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Expression of Genes for Methylxanthine Pathway-Associated Enzymes Accompanied by Sex Steroid Receptor Status Impacts Breast Carcinoma Progression

Abstract

Consumption of methylxanthine alkaloids appears to induce activities by antagonizing adenosine receptors, implicated in breast cancer behavior in vitro. Our goal was to evaluate expression of genes for methylxanthine receptors and metabolizing enzymes to assess risk of breast carcinoma recurrence. Clinical outcomes, estrogen/progestin receptor results, and gene expression assays guided selection. RNA was isolated from laser capture microdissection-procured carcinoma cells for microarray using established protocols. Gene expression levels of eight methylxanthine receptors, eight metabolizing enzymes, and various phosphodiesterases were retrieved from microarray results. Univariable Cox regressions and Kaplan-Meier plots were determined for each gene with R software. Individually, lower expressions of PDE4A, CYP2A6, or CYP2E were related to decreased progression-free survival (PFS) and overall survival (OS). PDE1A over-expression predicted decreased PFS and OS. ADORA2B and RYR1 over-expressions predicted diminished OS. ER+ cancers exhibited lower ADORA1, ADORA2B, and RYR1 and elevated PDE4A, CYP2A6, and CYP2E expressions. Of PR+ carcinomas, diminished ADORA2B and RYR1 and elevated expressions of ADORA3, PDE4A, CYP2C8, and CYP2E were noted. Least absolute shrinkage and selection operator (LASSO) revealed that CYP2E, PDE1A, and PDE4A expressions collectively predicted PFS whereas ADORA1, CYP2E, PDE1A, PDE1B, and PDE4A expressions jointly predicted OS. Models were clinically significant when validated externally. LASSO also derived a six-gene model and five-gene model that predicted PFS of ER− or PR− carcinomas, respectively. Similarly, five-gene and four-gene models predicted OS in ER− or PR− carcinomas, respectively. Collectively, expression of genes involved in methylxanthine action and metabolism in single-cell types predicted clinical outcomes of breast carcinoma indicating promise for developing diagnostics and design of new therapeutics.

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Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins

Publication date: December 2017
Source:Free Radical Biology and Medicine, Volume 113
Author(s): Jeremy A. Whitson, Phillip A. Wilmarth, John Klimek, Vincent M. Monnier, Larry David, Xingjun Fan
PurposeTo determine global protein expression changes in the lens of the GSH-deficient LEGSKO mouse model of age-related cataract for comparison with recently published gene expression data obtained by RNA-Seq transcriptome analysis.MethodsLenses were separated into epithelial and cortical fiber sections, digested with trypsin, and labeled with isobaric tags (10-plex TMT^TM). Peptides were analyzed by LC-MS/MS (Orbitrap Fusion) and mapped to the mouse proteome for relative protein quantification.Results1871 proteins in lens epithelia and 870 proteins in lens fiber cells were quantified. 40 proteins in LEGSKO epithelia, 14 proteins in LEGSKO fiber cells, 22 proteins in buthionine sulfoximine (BSO)-treated LEGSKO epithelia, and 55 proteins in BSO-treated LEGSKO fiber cells had significantly (p<0.05, FDR<0.1) altered protein expression compared to WT controls. HSF4 and MAF transcription factors were the most common upstream regulators of the response to GSH-deficiency. Many detoxification proteins, including aldehyde dehydrogenases, peroxiredoxins, and quinone oxidoreductase, were upregulated but several glutathione S-transferases were downregulated. Several cellular stress response proteins showed regulation changes, including an upregulation of HERPUD1, downregulation of heme oxygenase, and mixed changes in heat shock proteins. NRF2-regulated proteins showed broad upregulation in BSO-treated LEGSKO fiber cells, but not in other groups. Strong trends were seen in downregulation of lens specific proteins, including β- and γ-crystallins, lengsin, and phakinin, and in epithelial-mesenchymal transition (EMT)-related changes. Western blot analysis of LEGSKO lens epithelia confirmed expression changes in several proteins.ConclusionsThis dataset confirms at the proteomic level many findings from the recently determined GSH-deficient lens transcriptome and provides new insight into the roles of GSH in the lens, how the lens adapts to oxidative stress, and how GSH affects EMT in the lens.

Graphical abstract

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Radiologists are actually well-positioned to innovate in patient experience

Publication date: Available online 2 October 2017
Source:Current Problems in Diagnostic Radiology
Author(s): Ravi V. Gottumukkala, Thang Q. Le, Richard Duszak, Anand M. Prabhakar
Patient experience is becoming increasingly prioritized, most notably as a component of recently passed healthcare legislation that aims to link physician reimbursement to quality of care and cost effectiveness. For several reasons, radiologists are better positioned to seize opportunities to enhance patient experience than is readily apparent. We propose that discrete components along the imaging value chain can be evaluated specifically for their impact on patient experience and improved to this end. We also emphasize that the field of radiology has traditionally been the earliest adopter and a serial innovator in health information technology, and we suggest possible ways to leverage the newest technological tools to improve patient experience. Finally, we discuss how carefully vetted opportunities for direct patient interaction might expand the reach of diagnostic radiologists as members of integrated health systems. We believe that emerging patient experience metrics present unconventional opportunities for radiologists to make imaging even more meaningful for the many patients who entrust us with their care.



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A prospective study evaluating the utility of a 2-mm biopsy margin for complete removal of histologically atypical (dysplastic) nevi

Publication date: Available online 2 October 2017
Source:Journal of the American Academy of Dermatology
Author(s): Vitaly Terushkin, Elise Ng, Jennifer A. Stein, Susan Katz, David E. Cohen, Shane Meehan, David Polsky
BackgroundComplete removal of individual dysplastic nevi (DN) is often accomplished by a second surgical procedure after the initial biopsy. The choice to perform the second procedure is strongly influenced by histopathologic margin status of the initial biopsy specimen.ObjectiveTo evaluate the clinical and histopathologic outcomes of in toto biopsy of DN using a predetermined margin of normal skin.MethodsWe conducted a prospective study of a saucerization method using a defined 2-mm margin in patients undergoing biopsy of a pigmented skin lesion.ResultsWe performed 151 biopsies in 138 patients. Overall, 137 of 151 lesions subjected to biopsy (90.7%) were melanocytic: 86 DN (57.0%), 40 nevi without atypia (26.5%), and 11 melanomas (7.3%). Of 78 DN, 68 (87.2%) were removed with clear histopathologic margins (8 DN were excluded because of inadequate processing). There was no clinical evidence of recurrence at any of the biopsy sites that were simply observed (i.e., not re-excised) over a median of 16.9 months.LimitationsThere were few biopsies performed on the face.ConclusionsThe complete histopathologic removal of nearly 9 of 10 DN using a peripheral margin of 2 mm of normal skin and a depth at the dermis and subcutaneous fat junction has the potential to decrease second procedures at DN biopsy sites, thereby decreasing patient morbidity and saving health care dollars.



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Observational Study of Definitive (Chemo)Radiotherapy on Patients With Esophageal Cancer

Conditions:   Esophagus Cancer;   Chemoradiation;   Chemotherapy Effect;   Radiotherapy Side Effect
Intervention:  
Sponsors:   Chinese Academy of Medical Sciences;   Hebei Medical University Fourth Hospital;   Fujian Cancer Hospital;   Anyang Tumor Hospital;   The First Affiliated Hospital with Nanjing Medical University;   Affiliated Hospital of Hebei University;   Tianjin Medical University Cancer Institute and Hospital;   Beijing Hospital;   Tengzhou Central People's Hospital;   PLA Army General Hospital
Recruiting

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MiR-484 promotes non-small-cell lung cancer (NSCLC) progression through inhibiting Apaf-1 associated with the suppression of apoptosis

Publication date: December 2017
Source:Biomedicine & Pharmacotherapy, Volume 96
Author(s): Tao Li, Zong-Li Ding, Yu-Long Zheng, Wei Wang
Increasing studies have indicated that the dysregulated microRNAs (miRNAs) are associated with tumorigenesis, development and even the poor prognosis of a variety of tumors, including the non-small-cell lung cancer (NSCLC). Here in our study, we found that miRNA-484 was expressed highly in NSCLC clinical tumor samples in comparison to the matched adjacent tissues. In addition, high and low expression of miRNA-484 was observed in NSCLC cell lines and lung normal cells, respectively. Furthermore, the capability of migration and proliferation changed accompanied with the altered expression of miR-484 in NSCLC. Apoptotic protease activating factor-1 (APAF-1), frequently down-regulated in a number of types of cancer, was found to be reduced in NSCLC tissue samples or NSCLC cell lines along with high expression of miR-484, which were inversely expressed in Apaf-1 over-expressed tissues or cells. Moreover, miR-484 triggered the migration and proliferation, and simultaneously reduced the cleavage of poly (ADP-ribose) polymerase-2 (PARP-2) and Caspase-3 of A549 cells, which could be suppressed by the improvement of Apaf-1. And the inhibition of Apaf-1 could reverse the function caused by miR-484 in A549 cells, suggesting that Apaf-1 was targeted by miR-484 directly and it could be acted as a potential therapeutic target against NSCLC. In conclusion, the reductive Apaf-1 regulated by miR-484 accelerated the NSCLC cell progression associated with the inhibition of apoptosis via down-regulating Caspase-3 and PARP cleavage.



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Label-free quantitative proteomic analysis of drought stress-responsive late embryogenesis abundant proteins in the seedling leaves of two wheat (Triticum aestivum L.) genotypes

Publication date: Available online 2 October 2017
Source:Journal of Proteomics
Author(s): Na Li, Shuai Zhang, Yajun Liang, Yuhong Qi, Juan Chen, Weining Zhu, Linsheng Zhang
Late embryogenesis abundant (LEA) proteins are highly hydrophilic proteins with key roles in environmental stress responses. In this study, we performed the first survey of the LEA proteome in seedling leaves from two wheat genotypes subjected to drought stress, i.e., Shaanhe 6 (SH, drought-tolerant) and Zhengyin 1 (ZY, drought-sensitive). After isolating the LEA subpopulation by treating total soluble proteins with heating combined with 1% trichloroacetic acid treatment that was assessed by Western blotting of dehydrins, label-free proteomic analysis identified 38 LEA proteins or homologues belonging to seven LEA subfamilies in the two genotypes. The abundances of over half of the LEA proteins changed significantly after drought stress and they were involved in protection against drought, with at least 20 in SH and 14 in ZY. We found that the common differentially expressed LEA proteins increased in abundance more in the SH genotype compared with the ZY genotype, and six LEA proteins were significantly upregulated exclusively in the SH genotype, which may contribute to higher drought tolerance in SH. We also identified 221 non-LEA proteins from 12 functional categories. Our results provide a deeper understanding of the LEA expression patterns in response to drought stress in two wheat genotypes.SignificanceWe identified 38 LEA proteins or homologues from different LEA families in two wheat genotypes, thereby indicating the complex and versatile protective roles of LEA proteins in drought stress resistance. Moreover, the abundance of differentially expressed LEA proteins increased more in the SH genotype compared with the ZY genotype, and several LEA proteins with significant upregulation only in the SH genotype may contribute to its higher tolerance of drought stress. 221 non-LEA proteins were differentially accumulated in at least one of the SH and ZY genotypes. They are involved mainly with 12 biological functions and they might explain different drought responses of the two genotypes. The differentially expressed LEA and non-LEA proteins may be potential markers of drought tolerance to facilitate wheat breeding, particularly those that were specifically upregulated in the SH genotype, or with opposing expression patterns in the two genotypes.

Graphical abstract

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Scholar : Research in Drama Education: The Journal of Applied Theatre and Performance, Volume 22, Issue 4, November 2017 is now available online on Taylor & Francis Online

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The online platform for Taylor & Francis Online content Research in Drama Education: The Journal of Applied Theatre and Performance, Volume 22, Issue 4, November 2017 is now available online on Taylor & Francis Online. This new issue contains the following articles: Editorial Being happy Helen Nicholson Pages: 461-464 | DOI: 10.1080/13569783.2017.1376915 Research Articles Of models and mechanisms: towards an understanding of how theatre-making works as an 'intervention' in individual health and wellness Stephani Etheridge Woodson, Seline Szkupinski Quiroga, Tamara Underiner & Robert Farid Karimi Pages: 465-481 | DOI: 10.1080/13569783.2017.1366257 Amateur hour: culture, capital, and the Royal Shakespeare Company's Open Stages initiative Molly Flynn Pages: 482-499 | DOI: 10.1080/13569783.2017.1358082 Points and Practices Tackling local issues with applied theatre praxes in globalised Asia Wan-Jung Wang, Mei-Chun Lin, Jeffrey Tan, Setsu Hanasaki & Phoebe Yuk-Lan Chan Pages: 500-501 | DOI: 10.1080/13569783.2017.1366259 Opening homes and crossroads to tackle alienation and terrorism in Singapore Jeffrey Tan Pages: 502-505 | DOI: 10.1080/13569783.2017.1366258 Combating global issues of land reform, urbanisation and climate change with local community theatre devising and praxes in Taiwan Wan-Jung Wang Pages: 506-509 | DOI: 10.1080/13569783.2017.1366263 Tackling the idea of eugenics through applied theatre praxes in Japan Setsu Hanasaki Pages: 510-514 | DOI: 10.1080/13569783.2017.1366260 Considering the actor's artistry at a time of political change in Hong Kong Phoebe Yuk-Lan Chan Pages: 515-518 | DOI: 10.1080/13569783.2017.1366262 Facing the challenges of glocalisation of drama education in museum projects in Taiwan Mei-Chun Lin Pages: 519-522 | DOI: 10.1080/13569783.2017.1366261 Tackling local issues with applied theatre praxes in globalised Asia-Conclusion Wan-Jung Wang & Mei-Chun Lin Pages: 523-524 | DOI: 10.1080/13569783.2017.1366264 Research Articles Locating scenography in theatre for development projects at the University of Zimbabwe: the case of 'Safe Cities' project Nkululeko Sibanda & Privilledge Tatenda Gwaba Pages: 525-536 | DOI: 10.1080/13569783.2017.1358083 Storying worlds: using playback theatre to explore the interplay between personal and dominant discourses amongst adolescents Odia Jordaan & Marié-Heleen Coetzee Pages: 537-552 | DOI: 10.1080/13569783.2017.1359085 Operational sequencing: coping with contingency in process drama Thomas Rosendal Nielsen & Kjersti Hustvedt Pages: 553-569 | DOI: 10.1080/13569783.2017.1358081 Editorial Board Editorial Board Pages: ebi-ebi | DOI: 10.1080/13569783.2017.1376917 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Archives and Manuscripts are available online

The online platform for Taylor & Francis Online content New for Archives and Manuscripts and online now on Taylor & Francis Online: Book Review Cheap modernism: expanding markets, publishers' series, and the avant-garde Amy Hildreth Chen Pages: 1-2 | DOI: 10.1080/01576895.2017.1373583 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for African Security Review are available online

The online platform for Taylor & Francis Online content New for African Security Review and online now on Taylor & Francis Online: Features Between vigilantism and ethnocultural preservation: An investigation into the legitimacy of the non-state policing activities of the Ombatse group among the Eggon people of Nassarawa State, Nigeria Philip Adémọ́lá Ọláyọkù Pages: 1-21 | DOI: 10.1080/10246029.2017.1359639 Interested in the political-economic topics surrounding China? You wouldn't want to miss this exclusive collection. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Ozone flux in plant ecosystems: new opportunities for long-term monitoring networks to deliver ozone-risk assessments

Abstract

Ozone (O₃) is a photochemically formed reactive gas responsible for a decreasing carbon assimilation in plant ecosystems. Present in the atmosphere in trace concentrations (less than 100 ppbv), this molecule is capable of inhibiting carbon assimilation in agricultural and forest ecosystems. Ozone-risk assessments are typically based on manipulative experiments. Present regulations regarding critical ozone levels are mostly based on an estimated accumulated exposure over a given threshold concentration. There is however a scientific consensus over flux estimates being more accurate, because they include plant physiology analyses and different environmental parameters that control the uptake—that is, not just the exposure—of O₃. While O₃ is a lot more difficult to measure than other non-reactive greenhouse gases, UV-based and chemiluminescence sensors enable precise and fast measurements and are therefore highly desirable for eddy covariance studies. Using micrometeorological techniques in association with latent heat flux measurements in the field allows for the partition of ozone fluxes into the stomatal and non-stomatal sinks along the soil-plant continuum. Long-term eddy covariance measurements represent a key opportunity in estimating carbon assimilation at high-temporal resolutions, in an effort to study the effect of climate change on photosynthetic mechanisms. Our aim in this work is to describe potential of O₃ flux measurement at the canopy level for ozone-risk assessment in established long-term monitoring networks.

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Investigation of cosolvent application to enhance POPs’ mass transfer in partitioning passive sampling in sediment

Abstract

The freely dissolved concentration of persistent organic pollutants (POPs) is one of the most important parameters for risk assessment in aquatic environments, due to its proportionality to the chemical activity. Chemical activity difference represents the driving force for a spontaneous contaminant transport, such as water-aquatic biota or water-sediment. Freely dissolved concentrations in sediment pore water can be estimated from the concentrations in a partition-based passive sampler equilibrated in suspensions of contaminated sediment. Equilibration in the sediment/passive sampler system is slow, since concentrations of most POPs in the water phase, which is the main route for mass transfer, are very low. Adding methanol to sediment in suspension increases the POPs' solubility and, consequently, the permeability in the water phase. The resulting higher aqueous concentrations enhance POPs mass transfer up to three times for investigated POPs (polycyclic aromatic hydrocarbons, polychlorinated biphenyls, organochlorine pesticides) and shorten equilibrium attainment to less than 6 weeks. The addition of methanol to the aqueous phase up to a molar fraction of 0.2 changed the POPs equilibrium distribution ratio between sediment and passive sampler by less than a factor of two. As a result, the pore water concentrations of POPs, calculated from their amounts accumulated in a passive sampler, are affected by methanol addition not more than by the same factor.

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