Scholar : Undersea "Hyperbaric Medicine" - νέα αποτελέσματα

[HTML] Hyperbaric, Physiological And Pharmacological Effects Gases

AC Kahle, JS Cooper - 2017

… Undersea Hyperb Med. 2016 Nov-Dec;43(7):781-786. [PubMed: 28777515]. Copyright © 2017,
StatPearls Publishing LLC … Bhutani S, Vishwanath G. Indian J Plast Surg. 2012 May;
45(2):316-24. Review Hyperbaric medicine for the hospital-based physician.[Hosp Pract (1995) …

[PDF] Tratamiento del pie diabético y oxígeno hiperbárico

NB Mateos, MC Jiménez, AP Pinto - Salud y cuidados durante el desarrollo

… También, según la Underwater and Hyperbaric Medical Society, entre 1967 y 2011 se dataron
cuarenta y dos incendios en cámaras provocando noventa y seis muertes (Sheffield, y Desautels,
1997) … Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric …

 

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Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα

Oral mucosa lesions and gingival bleeding can indicate the progression of liver disease in children and adolescents aged two to 18 years

D Olczak‐Kowalczyk, E Krasuska‐Sławińska… - Acta Paediatrica

… angular cheilitis (52.5%) were the most common symptoms of oral candidiasis, while erythema
(36.8%) and median rhomboid glossitis (15.8%) occurred less frequently. Control … glossitis, were
also observed in other studies (9,25). No correlation between symptoms of …

[PDF] Erişkinde Spontan Gelişen Dil Absesi

V GÜNGÖR, MB SAYGILI, D BAKLACI, RO KUM…

… 3 Turkiye Klinikleri J Int Med Sci 2008, 4 3 Page 4. 4 1. Byrd JA, Bruce AJ, Rogers RS III. Glossitis
and other ton- gue disorders. Dermatol Clin 2003;21:123-34. 2. Jain HK, Bhatia PL. Lingual
abscess. J Laryngol Otol 1970;84:637-41. 3. Eviatar E, Pitaro K, Segal S, et al …

Аутоиммунный гастрит: патогенез, современные подходы к диагностике и лечению

ЮВ Эмбутниекс, ИН Войнован, СВ Колбасников…

… point of view. World J. Gastroenterol. 2009;15(41):5121–28. 45. Zhu JC, Wang YF,
Sheng J., Chen FX, Tang GY Atrophic glossitis is attributed to cobalamin deficiency.
Shanghai J. Stomatol. 2013;22(1):58–62. 46. Carabotti M …

 

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Scholar : ΑΚΟΗ - νέα αποτελέσματα

Psammetichus's Experiment and the Scholastics: Is Language Innate?

S Ebbesen - The Language of Thought in Late Medieval Philosophy, 2017

… Radulphus Brito, Quaest. Prisc. min. q. I. 1, 91–92. 8. Aristotle, Sens. 1, 437a3–17:
"αὐτῶν δὲ τούτων πρὸς μὲν τὰ ἀναγκαῖα κρείττων ἡ ὄψις καθ' αὑτήν, πρὸς δὲ
νοῦν κατὰ συμβεβηκὸς ἡ ἀκοή. διαφορὰς μὲν γὰρ πολλὰς …

[PDF] МЕТАФОРИЧНОСТЬ И МЕТОНИМИЯ В СРЕДНЕВЕКОВОЙ РУССКОЙ РЕЧИ

ВВ Колесов

… στόμα; Page 7. Метофоричность и метонимия в средневековой русской речи 77
ухо 'ухо' 1117, 'слух' 1057, 'внимание' 1096, 'ушко иглы' 1057, 'проушина' XIII в. –
все это точные переводы греческих слов ὦτα, ὠτίον, ἀκοή; ср …

 

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Scholar : Myringotomy and tubes - νέα αποτελέσματα

[PDF] Treatment of vasospasm in bacterial meningitis with hemodynamic augmentation

S JL, AM Ball, AM Namen, KL Tucker - 2017

… middle cranial fossa concerning for possible epidural abscess or subdural empyema.
Otolaryngology placed a right myringotomy with tympanostomy tube. Neurosurgery
then performed a lumbar puncture (results listed in Table 1 …

 

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Scholar : ΦΩΝΗ - νέα αποτελέσματα

[PDF] THE IDEA OF GOD'S PROVIDENCE AND THE INFLUENCE OF THE HOLY SCRIPTURE AS REFLECTED IN PORPHYROGENITUS'VITA BASILII

T Serreqi Jurić - FLUMINENSIA: časopis za filološka istraživanja, 2017

… puta, no samo na trima mjestima u značenju „Božja providnost";19 od sintagmi slična značenja
zatječemo θεία φωνή „Božji glas",20 θεία πρόγνωσις „Božje predviđanje",21 θεία κέλευσις „Božja
zapovijed",22 θεία ἔκλαμψις „Božje prosvjetljenje".23 Stoga se s pravom možemo …

 

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Scholar : Laryngotracheal reconstruction - νέα αποτελ

Severe macroglossia after posterior fossa and craniofacial surgery in children

J Bouaoud, A Joly, A Picard, B Thierry, E Arnaud… - International Journal of Oral …, 2018

… Images A and B show the condition immediately postoperative, with progressive macroglossia
and the use of an oral device (red arrow in image A). Image C shows a three-dimensional
reconstruction from a computed tomography scan … Laryngotracheal stenosis in children …

 

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Scholar : intitle:Bioprinting - νέα αποτελέσματα

3D Bioprinting of Self‐Standing Silk‐Based Bioink

Z Zheng, J Wu, M Liu, H Wang, C Li, MJ Rodriguez… - Advanced Healthcare …, 2017

Abstract Silk/polyethylene glycol (PEG) hydrogels are studied as self-standing bioinks for 3D
printing for tissue engineering. The two components of the bioink, silk fibroin protein (silk)
and PEG, are both Food and Drug Administration approved materials in drug and medical

 

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Scholar : Decannulation - νέα αποτελέσματα

[PDF] The Contemporary Treatment of Hypopharyngeal Cancer: Options for Function Preservation Strategies

PJ Bradley - EDITORIAL BOARD, 2017

… side-effects. 24 Patients who require a tracheostomy before treatment have low rates
of decannulation and higher short term mortality than those who do not require
tracheostomy before organ-preservation therapy. 95 Suicide …

 

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Scholar : These new articles for Aphasiology are available online

The online platform for Taylor & Francis Online content New for Aphasiology and online now on Taylor & Francis Online: Original Articles What happens when they think they are right? Error awareness analysis of sentence comprehension deficits in aphasia | Miren Arantzeta, Janet Webster, Itziar Laka, Maite Martínez-Zabaleta & David Howard Pages: 1-27 | DOI: 10.1080/02687038.2017.1423270 Routledge Psychology 2017 sponsor of BPS #PsychCrunch podcasts. Access 25 journal articles: http://bit.ly/psychcrunch2017 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Effects of tactile feedback on lumbar multifidus muscle activity in asymptomatic healthy adults and patients with low back pain

Publication date: Available online 6 January 2018
Source:Journal of Bodywork and Movement Therapies
Author(s): Sharon Wang-Price, Jason Zafereo, Kelli Brizzolara, Elizabeth Anderson
BackgroundReduced lumbar multifidus (LM) muscle contraction has been observed in patients with low back pain (LBP). Clinicians often use various strategies to ensure LM activation, including tactile feedback and verbal instruction. However, the effects of tactile feedback on muscle activation have not been studied previously. Therefore, the purpose of this study was to investigate whether or not tactile feedback would increase LM muscle activity in adults with and without LBP.MethodsTwenty asymptomatic adults and 20 patients with existing LBP completed the study. Two electromyographic (EMG) electrodes were applied to both sides of the LM at the L5 segment. EMG activity was collected three times at rest with and without tactile feedback, then five times during contralateral arm lifts with and without tactile feedback. The tactile feedback was applied by direct and continuous hand contact to the bilateral LM over the lumbosacral area. Lastly, two 5-second trials of maximum voluntary isometric contraction (MVIC) during a bilateral arm lift were performed. EMG activity collected at rest and during contralateral arm lifts was normalized to that collected during MVIC. Normalized EMG values of the right side of the asymptomatic group and the painful side of the LBP group were used for data analysis.ResultsStatistical analysis showed significantly decreased LM EMG activity with tactile feedback both at rest and during contralateral arm lifts compared to LM EMG activity without tactile feedback. There was no difference in LM EMG between the asymptomatic and the LBP groups.ConclusionsThe results of the study showed that adding tactile stimulation to verbal instruction appeared to provide an inhibitory effect on LM activity in both asymptomatic healthy adults and patients with LBP. Contrary to common belief, tactical feedback via direct hand contact may reduce LM muscle recruitment, and may lessen the desired treatment effect.



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Scholar : These new articles for Research in Dance Education are available online

The online platform for Taylor & Francis Online content New for Research in Dance Education and online now on Taylor & Francis Online: Original Articles New observations on the influence of dance on body image and development of eating disorders Ofra Walter & Sivan Yanko Pages: 1-12 | DOI: 10.1080/14647893.2017.1420767 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Development of layered PLGA membranes for periodontal tissue regeneration

Publication date: Available online 5 January 2018
Source:Dental Materials
Author(s): Itsumi Yoshimoto, Jun-Ichi Sasaki, Ririko Tsuboi, Satoshi Yamaguchi, Haruaki Kitagawa, Satoshi Imazato
ObjectiveVarious commercial products are available for guided tissue regeneration (GTR) therapy; however, they do not combine biosafety with the ability to control cell function. The purpose of this study was to evaluate the physicochemical and biological characteristics of the novel bilayer biodegradable poly(lactic-co-glycolic acid) (PLGA) membrane, and to assess whether the bilayer PLGA membrane could be used for periodontal tissue regeneration.MethodsBilayer biodegradable membrane was fabricated thorough a two-step freezing and lyophilization process using PLGA solution. The characteristics of bilayer membranes were evaluated with respect to surface morphology, stability, mechanical strength, and operability for clinical use. Cell proliferation and osteogenic differentiation were investigated on the each surface of bilayer membrane. Then, these membranes were implanted to the rat calvaria bone defect models and evaluated their capability for tissue regeneration.ResultsBiodegradable membranes composed of the solid and porous layer were successfully prepared and the surface morphologies analyzed. Physicochemical analyses revealed that the membranes possessed enough stability and mechanical properties for clinical use. It was also confirmed that the solid layer inhibited cell proliferation and subsequent connective tissue invasion, while the inner layer promoted proliferation and osteogenic differentiation, thus resulting in bone regeneration in vivo.SignificanceThe layering technology used to fabricate the bilayer polymer membrane could be applied in the developing of other novel biomaterials. The present study demonstrates that the bilayer biodegradable polymer membranes facilitate tissue regeneration in vivo, and therefore represent a prospective biomaterial for GTR therapy.



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Editorial Board

Publication date: January 2018
Source:Clinical Therapeutics, Volume 40, Issue 1





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Table of Contents

Publication date: January 2018
Source:Clinical Therapeutics, Volume 40, Issue 1





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EACPT News

Publication date: January 2018
Source:Clinical Therapeutics, Volume 40, Issue 1





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Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation

Publication date: March 2018
Source:Biomaterials, Volume 159
Author(s): Christopher P. Jackman, Asvin M. Ganapathi, Huda Asfour, Ying Qian, Brian W. Allen, Yanzhen Li, Nenad Bursac
Functional cardiac tissue engineering holds promise as a candidate therapy for myocardial infarction and heart failure. Generation of "strong-contracting and fast-conducting" cardiac tissue patches capable of electromechanical coupling with host myocardium could allow efficient improvement of heart function without increased arrhythmogenic risks. Towards that goal, we engineered highly functional 1 cm × 1 cm cardiac tissue patches made of neonatal rat ventricular cells which after 2 weeks of culture exhibited force of contraction of 18.0 ± 1.4 mN, conduction velocity (CV) of 32.3 ± 1.8 cm/s, and sustained chronic activation when paced at rates as high as 8.7 ± 0.8 Hz. Patches transduced with genetically-encoded calcium indicator (GCaMP6) were implanted onto adult rat ventricles and after 4–6 weeks assessed for action potential conduction and electrical integration by two-camera optical mapping of GCaMP6-reported Ca²⁺ transients in the patch and RH237-reported action potentials in the recipient heart. Of the 13 implanted patches, 11 (85%) engrafted, maintained structural integrity, and conducted action potentials with average CVs and Ca²⁺ transient durations comparable to those before implantation. Despite preserved graft electrical properties, no anterograde or retrograde conduction could be induced between the patch and host cardiomyocytes, indicating lack of electrical integration. Electrical properties of the underlying myocardium were not changed by the engrafted patch. From immunostaining analyses, implanted patches were highly vascularized and expressed abundant electromechanical junctions, but remained separated from the epicardium by a non-myocyte layer. In summary, our studies demonstrate generation of highly functional cardiac tissue patches that can robustly engraft on the epicardial surface, vascularize, and maintain electrical function, but do not couple with host tissue. The lack of graft-host electrical integration is therefore a critical obstacle to development of efficient tissue engineering therapies for heart repair.



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Platelet membrane coating coupled with solar irradiation endows a photodynamic nanosystem with both improved antitumor efficacy and undetectable skin damage

Publication date: March 2018
Source:Biomaterials, Volume 159
Author(s): Lulu Xu, Feng Gao, Feng Fan, Lihua Yang
The therapeutic efficacy of tumor photodynamic therapy (PDT) is hindered by the following three challenges. The extremely short lifetime of reactive oxygen species (ROS, the cytotoxic factor of PDT) limits the radius of their action to tens-of-nanometer scale; functionalizing a photodynamic nanosystem with active targeting moieties helps bring the target cells into reach of ROS but requires extra research efforts. Current photodynamic systems are in general excited by light on the short end of near-infrared (NIR) region; deep tissue penetration necessitates the development of those excitable by longer NIR light. Reducing irradiation dose is necessary for avoiding skin damages but impacts the therapeutic outcome; how to resolve this delimma remains a challenge. We herein show that platelet membrane-coating over a photodynamic nanoparticle coupled with solar irradiation may simultaneously resolve all challenges above. Platelet membrane-coating provides both long circulation and active targeting, leading to preferential internalization by tumor over fibroblast cells in vitro and higher tumor uptake than the red blood cell (RBC) membrane-coated counterpart. Preloading a photodynamic sensitizer into a synthetic nanocarrier shifts its absorption peak to longer wavelength, which favors deep tissue penetration. Upon irradiation with NIR light from a solar simulator at extremely low output power density, the platelet membrane-coated photodynamic-nanoparticle outperforms its RBC membrane-coated counterpart and effectively ablates tumor without causing skin damages, which underscores the importance of active targeting in tumor PDT. We anticipate that platelet membrane coating may facilitate the in vivo applications of antitumor photodynamic therapy.



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Degradable rhenium trioxide nanocubes with high localized surface plasmon resonance absorbance like gold for photothermal theranostics

Publication date: March 2018
Source:Biomaterials, Volume 159
Author(s): Wenlong Zhang, Guoying Deng, Bo Li, Xinxin Zhao, Tao Ji, Guosheng Song, Zhiyin Xiao, Qing Cao, Jingbo Xiao, Xiaojuan Huang, Guoqiang Guan, Rujia Zou, Xinwu Lu, Junqing Hu
The applications of inorganic theranostic agents in clinical trials are generally limited to their innate non-biodegradability and potential long-term biotoxicity. To address this problem, herein via a straightforward and tailored space-confined on-substrate route, we obtained rhenium trioxide (ReO3) nanocubes (NCs) that display a good biocompatibility and biosafety. Importantly, their aqueous dispersion has high localized surface plasmon resonance (LSPR) absorbance in near-infrared (NIR) region different from previous report, which possibly associates with the charge transfer and structural distortion in hydrogen rhenium bronze (HxReO3), as well as ReO3's cubic shape. Such a high LSPR absorbance in the NIR region endows them with photoacoustic (PA)/infrared (IR) thermal imaging, and high photothermal conversion efficiency (∼57.0%) for efficient ablation of cancer cells. Also, ReO3 NCs show X-ray computed tomography (CT) imaging derived from the high-Z element Re. More attractively, those ReO3 NCs, with pH-dependent oxidized degradation behaviors, are revealed to be relatively stable in hypoxic and weakly acidic microenvironment of tumor for imaging and treatment whilst degradable in normal physiological environments of organs to enable effective clearance. In spite of their degradability, ReO3 NCs still possess tumor targeting capabilities. We thus develop a simple but powerful, safe and biodegradable inorganic theranostic platform to achieve PA/CT/IR imaging-guided cancer photothermal therapy (PTT) for improved therapeutic efficacy and decreased toxic side effects.



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Improving the anesthetic process by a fuzzy rule based medical decision system

Publication date: Available online 5 January 2018
Source:Artificial Intelligence in Medicine
Author(s): Juan Albino Mendez, Ana Leon, Ayoze Marrero, Jose M. Gonzalez-Cava, Jose Antonio Reboso, Jose Ignacio Estevez, José F. Gomez-Gonzalez
ObjectiveThe main objective of this research is the design and implementation of a new fuzzy logic tool for automatic drug delivery in patients undergoing general anesthesia. The aim is to adjust the drug dose to the real patient needs using heuristic knowledge provided by clinicians. A two-level computer decision system is proposed. The idea is to release the clinician from routine tasks so that he can focus on other variables of the patient.MethodsThe controller uses the Bispectral Index (BIS) to assess the hypnotic state of the patient. Fuzzy controller was included in a closed-loop system to reach the BIS target and reject disturbances. BIS was measured using a BIS VISTA monitor, a device capable of calculating the hypnosis level of the patient through EEG information. An infusion pump with propofol 1% is used to supply the drug to the patient. The inputs to the fuzzy inference system are BIS error and BIS rate. The output is infusion rate increment. The mapping of the input information and the appropriate output is given by a rule-base based on knowledge of clinicians.ResultsTo evaluate the performance of the fuzzy closed-loop system proposed, an observational study was carried out. Eighty one patients scheduled for ambulatory surgery were randomly distributed in 2 groups: one group using a fuzzy logic based closed-loop system (FCL) to automate the administration of propofol (42 cases); the second group using manual delivering of the drug (39 cases). In both groups, the BIS target was 50.ConclusionsThe FCL, designed with intuitive logic rules based on the clinician experience, performed satisfactorily and outperformed the manual administration in patients in terms of accuracy through the maintenance stage.



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Response to XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage

Publication date: Available online 5 January 2018
Source:DNA Repair
Author(s): Richard D. Wood, Mandira Manandhar, Megan Lowery, Karen S. Boulware, Kevin Lin, Yue Lu




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Proton beam therapy for skull base chordomas in 106 patients: A dose adaptive radiation protocol

Publication date: Available online 6 January 2018
Source:Radiotherapy and Oncology
Author(s): Vivien Fung, Valentin Calugaru, Stéphanie Bolle, Hamid Mammar, Claire Alapetite, Philippe Maingon, Ludovic De Marzi, Sébastien Froelich, Jean-Louis Habrand, Rémi Dendale, Georges Noël, Loïc Feuvret
Background and purposeTo evaluate clinical results and safety of a dose adaptive protocol based on tumor volume coverage and critical structure constraints, for the treatment of skull base chordomas.Material and methodsBetween May 2006 and October 2012, 106 patients with skull base chordoma were treated by combined photon and proton irradiation. Prescribed dose levels were 68.4, 70.2, 72 and 73.8 Gy(RBE) in once daily fractionation of 1.8 Gy(RBE). Dose level and dosimetric constraints to organs at risk depended on postoperative residual Gross Tumor Volume (GTV) coverage. Local control (LC) and overall survival (OS) were evaluated using the Kaplan–Meier method.ResultsWith a median follow-up of 61 months, the 2-year, 4-year, and 5-year LC rates were 88.6%, 78.3%, and 75.1%, respectively. GTV > 25 mL (p = 0.034, HR = 2.22; 95%CI 1.06–4.62) was an independent unfavorable prognostic factor of LC.The 2-year, 4-year, and 5-year OS rates were 99%, 90.2%, and 88.3%, respectively.Grade 3–5 late toxicity was observed in 7 patients, resulting in 93% 5-year freedom from high-grade toxicity.ConclusionsThis study suggests that the probability of LC of skull base chordomas depends on postoperative GTV. The dose adaptive protocol achieves acceptable local control. Future studies should investigate whether further dose escalation to doses in excess of 74 Gy(RBE) would achieve better results.



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