Scholar : ΜΕΝΙΕΡΕ - νέα αποτελέσματα

[HTML] 어지럼 환자의 임상접근

박재한， 도영록， 김지수 - Journal of the Korean Medical Association, 2018

… 자세에 상관없는 자발어지럼이 반복적으로 발생하는 경우로 어지럼발작 사이에는 증상이 없는 기간이
존재한다[9]. 대표적인 질환들로는 Meniere 병, 전정편두통, 척추뇌기저허혈, 심인성어지럼 등이
있다[5, 9]. 재발성자발어지럼은 급성자발지속어지럼을 보이는 환자들에 비해 그 …

SEARCH SERVICE PROVIDING DEVICE, METHOD, AND COMPUTER PROGRAM

CS Gang, DY Kim - US Patent App. 15/696,288, 2017

… 4, the controller 120 of the search service providing device 100 may determine, in relation to
the initial search word of 'dizziness', first additional search words 174 of 'Meniere's disease',
'vestibular neuritis', 'benign paroxysmal vertigo' and 'stroke', which may cause dizziness …

Juger les fous au Moyen Âge: Dans les tribunaux royaux en France XIVe-XVe siècles

M Ternon - 2018

[PDF] Pacific Rim Otolaryngology–Head and Neck Surgery Update

MB Gillespie, ML Hinni, JD Rawnsley, AH Murr…

Page 1. Presented by the Department of Otolaryngology-Head and Neck Surgery
University of California, San Francisco Pacific Rim Otolaryngology– Head and Neck
Surgery Update GUEST SPEAKERS M. Boyd Gillespie, MD …

Rehabilitation After Traumatic Brain Injury

BC Eapen, DX Cifu - 2018

 

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Scholar : Decannulation - νέα αποτελέσματα

[PDF] FACING THE UNCERTAINTY OF ASTHMA CONTROL SURING PREGNANCY

J Branco, F Todo-Bom, S Furtado - Revista Portuguesa de Pneumología, 2017

Page 1. Revista Portuguesa de Pneumología ISSN: 0873-2159 sppneumologia@
mail.telepac.pt Sociedade Portuguesa de Pneumologia Portugal POSTERS
COMENTADOS Revista Portuguesa de Pneumología, vol. 23, núm …

[PDF] A INCERTEZA DO CONTROLO DA ASMA DURANTE A GRAVIDEZ

J Branco, F Todo-Bom, S Furtado, AR Silva… - Revista Portuguesa de …, 2017

Page 1. Revista Portuguesa de Pneumología ISSN: 0873-2159 sppneumologia@
mail.telepac.pt Sociedade Portuguesa de Pneumologia Portugal POSTERS
COMENTADOS Revista Portuguesa de Pneumología, vol. 23, núm …

 

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Scholar : ΠΑΡΕΣΗ BELL - νέα αποτελέσματα

Paradoxical Frontalis Activation: An Underrecognized Consequence of Facial Palsy

L Cooper, C Izard, V Harries, C Neville, V Venables… - Plastic and reconstructive …, 2018

… The majority of idiopathic or Bell palsies resolve com- pletely within 3 months.2–4 Of the
approximately one-third of facial palsy patients with delayed or incomplete recovery,1 more than
half … Frequency and location of synkineses in patients with peripheral facial nerve paresis …

Liu, Volpe, and Galetta's Neuro-Ophthalmology E-Book: Diagnosis and Management

GT Liu, NJ Volpe, SL Galetta - 2018

 

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Scholar : intitle:laryngeal - new results

Laryngeal disease. Endoscopic characterization of 1493 procedures based on age

JL Che-Morales, E Figueroa-Hurtado, A Cortes-Télles - Revista medica del Instituto …, 2018

Abstract Based on international epidemiology, some laryngeal diseases could be more
frequent at certain ages. The objective was to describe endoscopic findings in patients
through distinct decades of age in a laryngoscopy facility. retrospective and descriptive

 

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Scholar : Myringotomy and tubes - νέα αποτελέσματα

Лечение посттравматической сирингомиелии

АА Зуев, ВБ Лебедев, НВ Педяш, ДС Епифанов - Нейрохирургия, 2018

… Spine (Phila Pa 1976) 35 (21 Suppl):S245—S258, 2010 doi: 10.1097/BRS.0b013e3181f32e9c.
3. Leschke JM, Mumert ML, Kurpad SN Syringosubarachnoid shunting using a myringotomy
tube Surg. Neurol. Int. 2016; 7(Suppl 1): S8—S11 doi: 10.4103/2152-7806.173559 …

Surgical implement training process

L Foster - US Patent 9,847,044, 2017

… 5997307, Training device for myringotomy and middle ear surgery, December, 1999,
LeJeune, Jr. et al … Furthermore, electrical wiring, vacuum tubes, gas hoses and
garbage receptacles may be present in the operating room …

Goal Writing for the Speech-Language Pathologist and Special Educator

R Fabus, J Yudes-Kuznetsov, J Reilly-Limowski - 2018

Page 1. GOAL WRITING for the Speech-Language Pathologist and Special Educator Bridging
the Cap Between Assessment and Intervention N Terry H. Gozdziewski | Renee Fabus Cindy
Geise Arroyo J. Reilly Limowski Julia Yudes-Kuznetsov Page 2 …

 

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Scholar : ΛΟΓΟΣ - νέα αποτελέσματα

[PDF] Харьковский национальный университет искусств имени ИП Котляревского

Д Малый

… Подтверждением тому служит мысль Д. Шостаковича по поводу зна- чения мировоззрения
в качестве главного критерия, 3 От др.-греч. λόγος — «рассуждение», «мысль», «разум».
4 От др.-греч. τεχνικός ← τέχνη — «искусство», «мастерство», «умение». Page 4 …

 

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Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα

[PDF] Reproductive Health Indica-tors Among Women with Celiac Disease in Sudan at Ibn Sina Specialized Hos-pital from December 2014 to June 2015

SM Hassan, K Yassin, NA Zakaria - J Reprod Med Gynecol Obstet, 2017

… Di- arrhoea usually presents as well as constitutional symptoms of lassi- tude, weight loss, glossitis,
angular stomatitis and symptoms relating to anemia, vitamin D deficiency or osteoporosis may
be presenting problem in adults, others presentations in adults include depression …

[PDF] 16GLETXIV

VC Moser, M Aschner, RJ Richardson, MA Philbert

Page 1. 16GLETXIV Toxic Responses of the Nervous System Virginia C. Moser,
Michael Aschner, Rudy J. Richardson, and Martin A. Philbert Overview of the Nervous
System BloodiBrain Barrier Energy Requirements Axonal …

 

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Scholar : Laryngomalacia - νέα αποτελέσματα

[PDF] Pacific Rim Otolaryngology–Head and Neck Surgery Update

MB Gillespie, ML Hinni, JD Rawnsley, AH Murr…

Page 1. Presented by the Department of Otolaryngology-Head and Neck Surgery
University of California, San Francisco Pacific Rim Otolaryngology– Head and Neck
Surgery Update GUEST SPEAKERS M. Boyd Gillespie, MD …

 

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Scholar : Laryngotracheal reconstruction - νέα αποτελ

[PDF] Pacific Rim Otolaryngology–Head and Neck Surgery Update

MB Gillespie, ML Hinni, JD Rawnsley, AH Murr…

… Bryan Liming, MD 12:00 PM Versatility of the Submental Flap in Head and Neck Reconstruction
Michael L. Hinni, MD 12:30 Adjourn 5:00 Afternoon Case Discussions 6:00 PM Adjourn … Eric D.
Wirtz, MD 3:00 Coffee Break 3:30 Laryngotracheal Stenosis M. Boyd Gillespie, MD …

 

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Mind the Organelle Gap – Peroxisome Contact Sites in Disease

Publication date: Available online 31 January 2018
Source:Trends in Biochemical Sciences
Author(s): Inês Gomes Castro, Maya Schuldiner, Einat Zalckvar
The eukaryotic cell is organized as a complex grid system where membrane-bound cellular compartments, organelles, must be localized to the right place at the right time. One way to facilitate correct organelle localization and organelle cooperation is through membrane contact sites, areas of close proximity between two organelles that are bridged by protein/lipid complexes. It is now clear that all organelles physically contact each other. The main focus of this review is contact sites of peroxisomes, central metabolic hubs whose defects lead to a variety of diseases. New peroxisome contacts, their tethering complexes and functions have been recently discovered. However, if and how peroxisome contacts contribute to the development of peroxisome-related diseases is still a mystery.



http://ift.tt/2E7Lt1z

Protein Tertiary Structure by Crosslinking/Mass Spectrometry

Publication date: Available online 31 January 2018
Source:Trends in Biochemical Sciences
Author(s): Michael Schneider, Adam Belsom, Juri Rappsilber
Observing the structures of proteins within the cell and tracking structural changes under different cellular conditions are the ultimate challenges for structural biology. This, however, requires an experimental technique that can generate sufficient data for structure determination and is applicable in the native environment of proteins. Crosslinking/mass spectrometry (CLMS) and protein structure determination have recently advanced to meet these requirements and crosslinking-driven de novo structure determination in native environments is now possible. In this opinion article, we highlight recent successes in the field of CLMS with protein structure modeling and challenges it still holds.



http://ift.tt/2FzAD16

Influence of labile dissolved organic matter on nitrate reduction in a seepage face

Abstract

Seepage faces, the outer rim of subterranean estuaries, are an important reaction node for SGD-borne nitrate (NO₃⁻) on a global scale. Labile dissolved organic matter (DOM) has been suggested to be a key factor constraining the NO₃⁻ removal rate in aquifer systems. To determine whether and to what extent the availability of labile DOM affects benthic NO₃⁻ reduction in seepage faces, a series of flow-through reactor (FTR) experiments with sandy sediment collected from a seepage face was conducted under oxic conditions. Experimental results revealed that the addition of labile DOM (glucose) to porewater did not trigger a significant enhancement in NO₃⁻ reduction rate. In contrast, the aerobic respiration was boosted from ca. 50 to 90 μmol dm⁻³ sediment h⁻¹ by glucose amendments, accounting for approximately 70% consumption of the labile DOM pool. This rapid consumption may increase the NO₃⁻ reducing capability within the sediment, but only indirectly. Together with fluorescent DOM (FDOM) analyses, it can be inferred that NO₃⁻ reducers tend to choose sediment organic matter the prime electron donor under the experimental conditions. As a result, enrichment of DOM in seepage faces, depending on composition, might only stimulate aerobic respiration and nitrification, thus promoting the increase of ensuing NO₃⁻ fluxes to adjacent coastal waters.

http://ift.tt/2DQdTK0

For beginners in anaesthesia, self-training with an audiovisual checklist improves safety during anaesthesia induction: A prospective, randomised, controlled two-centre study

BACKGROUND Beginners in residency programmes in anaesthesia are challenged because working environment is complex, and they cannot rely on experience to meet challenges. During this early stage, residents need rules and structures to guide their actions and ensure patient safety. OBJECTIVE We investigated whether self-training with an electronic audiovisual checklist app on a mobile phone would produce a long-term improvement in the safety-relevant actions during induction of general anaesthesia. DESIGN, SETTING AND PARTICIPANTS During the first month of their anaesthesia residency, we randomised 26 residents to the intervention and control groups. The study was performed between August 2013 and December 2014 in two university hospitals in Germany. INTERVENTION In addition to normal training, the residents of the intervention group trained themselves on well tolerated induction using the electronic checklist for at least 60 consecutive general anaesthesia inductions. MAIN OUTCOME MEASURES After an initial learning phase, all residents were observed during one induction of general anaesthesia. The primary outcome was the number of safety items completed during this anaesthesia induction. Secondary outcomes were similar observations 4 and 8 weeks later. RESULTS Immediately, and 4 weeks after the first learning phase, residents in the intervention group completed a significantly greater number of safety checks than residents in the control group 2.8 [95% confidence interval (CI) 0.4 to 5.1, P = 0.021, Cohen's d = 0.47] and 3.7 (95% CI 1.3 to 6.1, P = 0.003, Cohen's d = 0.61), respectively. The difference between the groups had disappeared by 8 weeks: mean difference in the number of safety checks at 8 weeks was 0.4, 95% CI −2.0 to 2.8, P = 0.736, Cohen's d = 0.07). CONCLUSION The use of an audiovisual self-training checklists improves safety-relevant behaviour in the early stages of a residency training programme in anaesthesia. Correspondence to Dr Stefanie Beck, Department of Anaesthesiology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany E-mail: st.beck@uke.de © 2018 European Society of Anaesthesiology

http://ift.tt/2DQAzd2

Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A

Publication date: Available online 31 January 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Toby Passioura, Bhaskar Bhushan, Anthony Tumber, Akane Kawamura, Hiroaki Suga
The combination of genetic code reprogramming and mRNA display is a powerful approach for the identification of macrocyclic peptides with high affinities to a target of interest. We have previously used such an approach to identify a potent inhibitor (CP2) of the human KDM4A and KDM4C lysine demethylases; important regulators of gene expression. In the present study, we have used genetic code reprogramming to synthesise very high diversity focused libraries (> 10¹² compounds) based on CP2 and, through affinity screening, used these to delineate the structure activity relationship of CP2 binding to KDM4A. In the course of these experiments we identified a CP2 analogue (CP2f-7) with ∼4-fold greater activity than CP2 in in vitro inhibition assays. This work will facilitate the development of more potent, selective inhibitors of lysine demethylases.

Graphical abstract

http://ift.tt/2DRrRzb

Potent Human Glutaminyl Cyclase Inhibitors as Potential Anti-Alzheimer’s Agents: Structure-Activity Relationship Study of Arg-Mimetic Region

Publication date: Available online 31 January 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Van T.H. Ngo, Van-Hai Hoang, Phuong-Thao Tran, Jihyae Ann, Minghua Cui, Gyungseo Park, Sun Choi, Jiyoun Lee, Hee Kim, Hee-Jin Ha, Kwanghyun Choi, Young-Ho Kim, Jeewoo Lee
Pyroglutamate-modified amyloid β peptides (pGlu-Aβ) are highly neurotoxic and promote the formation of amyloid plaques. The pGlu-Aβ peptides are generated by glutaminyl cyclase (QC), and recent clinical studies indicate that QC represents an alternative therapeutic target to treat Alzheimer's disease (AD). We have previously developed a series of QC inhibitors with an extended pharmacophoric scaffold, termed the Arg-mimetic D-region. In the present study, we focused on the structure activity relationship (SAR) of analogues with modifications in the D-region and evaluated their biological activity. Most compounds in this series exhibited potent activity in vitro, and our SAR analysis and the molecular docking studies identified compound 202 as a potential candidate because it forms an additional hydrophobic interaction in the hQC active site. Overall, our study provides valuable insights into the Arg-mimetic pharmacophore that will guide the design of novel QC inhibitors as potential treatments for AD.

Graphical abstract

http://ift.tt/2nrb4Zy

Synthetic Peptide API Manufacturing A Mini Review of Current Perspectives for Peptide Manufacturing

Publication date: Available online 31 January 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Jon H. Rasmussen

Graphical abstract

http://ift.tt/2BIPEvd

Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI)

Publication date: Available online 31 January 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Lalgudi S. Harikrishnan, Jayakumar Warrier, Andrew J. Tebben, Gopikishan Tonukunuru, Sudhakara R. Madduri, Vishweshwaraiah Baligar, Raju Mannoori, Balaji Seshadri, Hasibur Rahaman, P.N. Arunachalam, Amol Dikundwar, Brian E. Fink, Joseph Fargnoli, Mark Fereshteh, Yi Fan, Jonathan Lippy, Ching-Ping Ho, Barri Wautlet, Steven Sheriff, Max Ruzanov, Robert M. Borzilleri
The TGFβ-TGFβR signaling pathway has been reported to play a protective role in the later stages of tumorigenesis via increasing immunosuppressive Treg cells and facilitating the epithelial to mesenchymal transition (EMT). Therefore, inhibition of TGFβR has the potential to enhance antitumor immunity. Herein we disclose the identification and optimization of novel heterobicyclic inhibitors of TGFβRI that demonstrate potent inhibition of SMAD phosphorylation. Application of structure-based drug design to the novel pyrrolotriazine chemotype resulted in improved binding affinity (Ki apparent = 0.14 nM), long residence time (T1/2 > 120 min) and significantly improved potency in the PSMAD cellular assay (IC50 = 24 nM). Several analogs inhibited phosphorylation of SMAD both in vitro and in vivo. Additionally, inhibition of TGFβ-stimulated phospho-SMAD was observed in primary human T cells.

Graphical abstract

http://ift.tt/2nsNbkf

Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics

Publication date: Available online 31 January 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Miloš Erak, Kathrin Bellmann-Sickert, Sylvia Els-Heindl, Annette G. Beck-Sickinger
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. In the last decades, peptide therapeutics became an emerging market in pharmaceutical industry. The need for synthetic strategies in order to improve peptidic properties, such as longer half-life, higher bioavailability, increased potency and efficiency is accordingly rising. In this mini-review, we present a toolbox of modifications in peptide chemistry for overcoming the main drawbacks during the transition from natural peptides to peptide therapeutics. Modifications at the level of the peptide backbone, amino acid side chains and higher orders of structures are described. Furthermore, we are discussing the future of peptide therapeutics development and their impact on the pharmaceutical market.

Graphical abstract

http://ift.tt/2nqF9Zk

Enhancing the anti-biofilm activity of 5-aryl-2-aminoimidazoles through nature inspired dimerisation

Publication date: Available online 31 January 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Tran Thi Thu Trang, Lise Dieltjens, Geert Hooyberghs, Kai Waldrant, Denis S. Ermolat'ev, Erik V. Van der Eycken, Hans P.L. Steenackers
The increased tolerance of biofilms against disinfectants and antibiotics has stimulated research into new methods of biofilm prevention and eradication. In our previous work, we have identified the 5-aryl-2-aminomidazole core as a scaffold that demonstrates preventive activity against biofilm formation of a broad range of bacterial and fungal species. Inspired by the dimeric nature of natural 2-aminoimidazoles of the oroidin family, we investigated the potential of dimers of our decorated 5-aryl-2-aminomidazoles as biofilm inhibitors. A synthetic approach towards 2-aminoimidazole dimers linked by an alkyl chain was developed and a total of 48 dimers were synthesized. The linkers were introduced at two different positions, the N1-position or the N2-position, and the linker length and the substitution of the 5-phenyl ring (H, F, Cl, Br) were varied. Although, no clear correlation between linker length and biofilm inhibition was observed, a strong increase in anti-biofilm activity for almost all N1,N1'-linked dimers was obtained, compared to the respective monomers against Salmonella Typhimurium, Escherichia coli and Staphylococcus aureus. The N2,N2'-linked dimers, having a H- or F-substitution, were also found to show a strong increase in anti-biofilm activity compared to the respective monomers against these three bacterial species and against Pseudomonas aeruginosa. In addition, the obtained growth measurements suggest a broad concentration range with specific biofilm inhibition and no effect on the planktonic growth against Salmonella Typhimurium and Pseudomonas aeruginosa.

Graphical abstract

http://ift.tt/2BJ98jB

Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors

Publication date: Available online 31 January 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Mario D. Martínez, Alberto A. Ghini, M. Virginia Dansey, Adriana S. Veleiro, Adali Pecci, Lautaro D. Alvarez, Gerardo Burton
The Liver X receptors (LXRs) are members of the nuclear receptor family, that play fundamental roles in cholesterol transport, lipid metabolism and modulation of inflammatory responses. In recent years, the synthetic steroid N,N-dimethyl-3 β -hydroxycholenamide (DMHCA) arised as a promising LXR ligand. This compound was able to dissociate certain beneficial LXRs effects from those undesirable ones involved in triglyceride metabolism. Here, we synthetized a series of DMHCA analogues with different modifications in the steroidal nucleus involving the A/B ring fusion, that generate changes in the overall conformation of the steroid. The LXRα and LXRβ activity of these analogues was evaluated by using a luciferase reporter assay in BHK21 cells. Compounds were tested in both the agonist and antagonist modes. Results indicated that the agonist/antagonist profile is dependent on the steroid configuration at the A/B ring junction. Notably, in contrast to DMHCA, the amide derived from lithocholic acid (2) with an A/B cis configuration and its 6,19-epoxy analogue 4 behaved as LXRα selective agonists, while the 2,19-epoxy analogues with an A/B trans configuration were antagonists of both isoforms. The binding mode of the analogues to both LXR isoforms was assessed by using 50 ns molecular dynamics (MD) simulations. Results revealed conformational differences between LXRα- and LXR β -ligand complexes, mainly in the hydrogen bonding network that involves the C-3 hydroxyl. Overall, these results indicate that the synthetized DMHCA analogues could be interesting candidates for a therapeutic modulation of the LXRs.

Graphical abstract

http://ift.tt/2nt78aA