Scholar : Obstructive sleep apnea - νέα αποτελέσματα

[HTML] Kinesthetic stimulation for obstructive sleep apnea syndrome: An "on-off" proof of concept trial

AI Hernández, D Pérez, D Feuerstein, C Loiodice… - Scientific Reports, 2018

Abstract Obstructive sleep apnea (OSA) occurs when the upper airway narrows or collapses
due to the loss of upper airway muscle activation at sleep onset. This study investigated the
effectiveness of triggered kinesthetic stimulation in patients with OSA. This proof-of-concept,

Comorbid obstructive sleep apnea and increased risk for sickle cell disease morbidity

T Katz, J Schatz, CW Roberts - Sleep and Breathing, 2018

Abstract Purpose Sickle cell disease (SCD) imparts an increased risk for obstructive sleep
apnea (OSA) in childhood. Studies of pediatric SCD have identified an increased risk for
pain and neurologic complications with comorbid OSA. We determined the rate of a broad

Nurse practitioners and physician assistants are qualified to perform home sleep apnea test clinical evaluations

LJ Colvin, A Cartwright, N Freedman, AE Rogers… - … American Academy of Sleep …, 2018

… Copyright © 2018 American Academy of Sleep Medicine. The American Academy of Sleep
Medicine's position statement on the clinical use of a home sleep apnea test addresses
board-certified sleep physician (BCSP) evaluation of obstructive sleep apnea (OSA) …

Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis

BT Keenan, J Kim, B Singh, L Bittencourt, NH Chen… - 2018

Abstract Study Objectives: A recent study of patients with moderate–severe obstructive sleep
apnea (OSA) in Iceland identified three clinical clusters based on symptoms and
comorbidities. We sought to verify this finding in a new cohort in Iceland and examine the

Assessment of oximetry-based statistical classifiers as simplified screening tools in the management of childhood obstructive sleep apnea

A Crespo, D Álvarez, L Kheirandish-Gozal… - Sleep and Breathing, 2018

Abstract Purpose A variety of statistical models based on overnight oximetry has been
proposed to simplify the detection of children with suspected obstructive sleep apnea
syndrome (OSAS). Despite the usefulness reported, additional thorough comparative

Cough hypersensitivity in patients with obstructive sleep apnea hypopnea syndrome

C Shi, S Liang, X Xu, Q Chen, L Wang, L Yu, H Lv… - Sleep and Breathing, 2018

Purpose The purpose of this study was to investigate cough hypersensitivity and its potential
mechanisms in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).
Methods Fifteen OSAHS patients, 12 simple snoring patients, and 15 healthy volunteers

Alterations of IGF-1, complement C3 and superoxide dismutase in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome

X Wang, Y Wang, Z Cai, X Lu, Z Li, Y Chen, G Zu, T Li - Biomarkers in Medicine, 2018

Aim: To evaluate various biomarkers of metabolism, immunity and inflammation in
obstructive sleep apnea hypopnea syndrome (OSAHS). Materials & methods: After overnight
polysomnography, blood was collected from 292 OSAHS patients or healthy volunteers.

[HTML] Association of Adenotonsillectomy With Blood Pressure Among Hypertensive and Nonhypertensive Children With Obstructive Sleep Apnea

CH Lee, KT Kang, SN Chiu, IS Chang, WC Weng… - JAMA Otolaryngology–Head …, 2018

Importance Hypertension in childhood may continue into adulthood and lead to adverse
cardiovascular outcomes. Evidence suggests that adenotonsillectomy for childhood
obstructive sleep apnea (OSA) may be associated with blood pressure (BP) improvement.

Effects of CPAP therapy on cognitive and psychomotor performances in patients with severe obstructive sleep apnea: a prospective 1-year study

R Pecotic, IP Dodig, M Valic, T Galic, LL Kalcina… - Sleep and Breathing, 2018

Study objectives We prospectively investigated the effects of continuous positive airway
pressure (CPAP) on long-term cognitive and psychomotor performances, and excessive
daytime sleepiness in severe obstructive sleep apnea (OSA) patients. Methods A total of 40

Palatal prolapse as a signature of expiratory flow limitation and inspiratory palatal collapse in patients with obstructive sleep apnoea

A Azarbarzin, SA Sands, M Marques, PR Genta… - European Respiratory …, 2018

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΜΑΣΤΟΕΙΔΙΤΙΣ - νέα αποτελέσμ

Mastoiditis aguda con absceso subperióstico por gérmenes emergentes

MEV Fernández, RC Fernández, AMV Alvarez - Medicina Clínica, 2018

La mastoiditis aguda es una infección de las celdillas mastoideas del hueso temporal y la
complicación más frecuente de la otitis media aguda (OMA), que puede progresar hacia la
destrucción de estructuras óseas adyacentes y desarrollar abscesos subperiósticos u otras

Neurological Complications of Acute and Chronic Otitis Media

MJ Hutz, DM Moore, AJ Hotaling - Current Neurology and Neuroscience Reports, 2018

… intracranial categories. Intratemporal complications include hearing loss, mastoiditis,
subperiosteal abscess, facial paralysis, petrous apicitis, labyrinthitis, and labyrinthine
fistula. Intracranial … Acute Mastoiditis. Mastoiditis is a …

How Efficacious is HRCT Temporal Bone in Determining the Ossicular Erosion in Cases of Safe and Limited Squamous Type CSOM?

J Singh, B Bhardwaj - Indian Journal of Otolaryngology and Head & Neck …, 2018

… Though otitis media is essentially a clinical diagnosis but high resolution computed tomography
(HRCT) is useful for showing evidence of ossicular erosion in acute and chronic mastoiditis, extent
of pneumatisation of temporal bone and relationship of pathology of adjacent …

[PDF] BRAIN ARTERIOVENOUS MALFORMATIONS

S Stojanović, A Spasić, MB Nikolić, D Kostić, M Karać… - 2018

… They represent about 10-15% of AVMs. Lesions of this type are most often acquired, and
etiological factors are of wide spectrum including dural phlebitis, trauma, infection of
paraendocranial structures (egmastoiditis). Primary cause of duralbAVMs is veinous hypertension …

[PDF] A STUDY OF OUTCOME OF TYMPANOPLASTY ASSCESSED BY AUDIOGRAM IN TERTIARY CARE HOSPITALS IN SOUTH INDIA

M Harini - INDIAN JOURNAL OF APPLIED RESEARCH, 2018

… 4. Patients who are willing to undergo all investigations. EXCLUSION CRITERIA: 1. Patient
not giving consent of study 2. Patients with complications like cholesteatoma and
mastoiditis. 3. Patients with mixed or sensorineural hearing loss …

[PDF] ANCA associated vasculitis in patients from Saudi Arabia

AS Al Arfaj, N Khalil - 2018

… Complications included infections, cush- ings syndrome, aseptic necrosis of hip and
shoulder, complex pulmonary aspergilloma, mastoiditis, side effect dysnea and itching
of hands and feet due to Abdurhman Saud Al Arfaj et al …

15 Staphylococcus aureus-Infektionen

S Rieg - FAQ Infektiologie, 2018

… Abszess oder Verhalt chirurgische oder inter- ventionelle Drainage essenziell; bei metastatischen
Absie- delungen immer Suche nach primärem Fokus und Aus- schluss Endokarditis Meningitis,
intraspinale oder epidurale Empyeme Mastoiditis, Parotitis Psoasabszess …

Life-Threatening Headaches in Children: Clinical Approach and Therapeutic Options

N Dalvi, L Sivaswamy - Pediatric Annals, 2018

… Clinical situations associated with intracranial abscess include otitis media, mastoiditis,
infective endocarditis, and patients who are immune compromised. The edema surrounding
an abscess may lead to a headache that is very difficult to treat …

[PDF] Role of symptoms in the diagnosis and management of acute otitis media in young children

J Uitti - 2018

Page 1. ANNALES UNIVERSITA TIS TURK UENSIS Johanna Uitti D 1335 Johanna
Uitti ROLE OF SYMPTOMS IN THE DIAGNOSIS AND MANAGEMENT OF ACUTE
OTITIS MEDIA IN YOUNG CHILDREN TURUN YLIOPISTON …

Infectious risk of biological drugs versus traditional systemic treatments in moderate to severe psoriasis: a cohort analysis in the French insurance database

S Couderc, M Lapeyre‐Mestre, R Bourrel, P Carle… - Fundamental & Clinical …, 2018

Page 1. Accepted Article This article has been accepted for publication and undergone full peer
review but has not been through the copyediting, typesetting, pagination and proofreading process,
which may lead to differences between this version and the Version of Record …

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΧΗΜΕΙΟΘΕΡΑΠΕΙΑ - νέα αποτελέ

[PDF] Μοριακή διερεύνηση περιστατικών πρωτοπαθούς καρκίνου του πνεύμονα και η συσχέτισή της με πιθανούς εξωγενείς επιβαρυντικούς παράγοντες

Σ Γιαννέλου - 2017

Page 1. 1 Γιαννέλου Σοφία Page 2. 2 Γιαννέλου Σοφία Στον σύζυγό µου Αλέξη και στα παιδιά
µας, Αριστόβουλο και Μαριτίνα. Page 3. 3 Γιαννέλου Σοφία Η παρούσα διπλωματική εργασία
εκπονήθηκε στο Εργαστήριο Βιολογικής Χημείας της Ιατρικής Σχολής του …

[PDF] Επιβίωση των παθογόνων μικροοργανισμών Listeria monocytogenes και Escherichia coli O157: H7 κατά την αυθόρμητη ζύμωση βολβών του είδους Raphanus sativus …

Σ Παππά - 2018

Page 1. ΓΕΩΠΟΝΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΑΘΗΝΩΝ ΤΜΗΜΑ ΕΠΙΣΤΗΜΗΣ ΤΡΟΦΙΜΩΝ
&ΔΙΑΤΡΟΦΗΣ ΤΟΥ ΑΝΘΡΩΠΟΥ Π.Μ.Σ.:«ΕΠΙΣΤΗΜΗ & ΤΕΧΝΟΛΟΓΙΑ ΤΡΟΦΙΜΩΝ
& ΔΙΑΤΡΟΦΗ ΤΟΥ ΑΝΘΡΩΠΟΥ» ΚΑΤΕΥΘΥΝΣΗ: «Συστήματα …

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΠΑΛΙΝΔΡΟΜΗΣΗ - νέα αποτελέσμ

[PDF] Μέθοδοι σταδιακής μάθησης σε Τεχνητά Νευρωνικά Δίκτυα

Α Δήμου - 2018

… Η εξόρυξη δεδομένων εντοπίζει νέες πληροφορίες σχετικά με δεδομένα που έχουν ήδη συλλεχθεί.
Οι βασικές εφαρμογές της εξόρυξής δεδομένων είναι η συσταδοποίηση, η ταξινόμηση, η
παλινδρόμηση, οι κανόνες συσχέτισης και ανίχνευση ανωμαλιών [6] … Παλινδρόμηση …

[PDF] Ο ρόλος των ψυχολογικών παραγόντων στην γυναικεία επιχειρηματικότητα στην Ελλάδα σε περίοδο οικονομικής κρίσης

Σ Νταβάλια - 2017

Page 1. i ΠΑΝΕΠΙΣΤΗΜΙΟ ΠΕΙΡΑΙΩΣ ΤΜΗΜΑ ΟΙΚΟΝΟΜΙΚΗΣ ΕΠΙΣΤΗΜΗΣ ΠΡΟΓΡΑΜΜΑ
ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ ΣΤΗΝ ΟΙΚΟΝΟΜΙΚΗ ΚΑΙ ΕΠΙΧΕΙΡΗΣΙΑΚΗ ΣΤΡΑΤΗΓΙΚΗ Ο ρόλος
των ψυχολογικών παραγόντων στην γυναικεια επιχειρηματικότητα στην Ελλάδα σε …

[PDF] Μοριακή διερεύνηση περιστατικών πρωτοπαθούς καρκίνου του πνεύμονα και η συσχέτισή της με πιθανούς εξωγενείς επιβαρυντικούς παράγοντες

Σ Γιαννέλου - 2017

Page 1. 1 Γιαννέλου Σοφία Page 2. 2 Γιαννέλου Σοφία Στον σύζυγό µου Αλέξη και στα παιδιά
µας, Αριστόβουλο και Μαριτίνα. Page 3. 3 Γιαννέλου Σοφία Η παρούσα διπλωματική εργασία
εκπονήθηκε στο Εργαστήριο Βιολογικής Χημείας της Ιατρικής Σχολής του …

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Transition in microstructural and mechanical behavior by reduction of sigma-forming element content in a novel high entropy alloy

Publication date: 5 May 2018
Source:Materials & Design, Volume 145
Author(s): Ahmad Raza, Byungchul Kang, Junho Lee, Ho Jin Ryu, Soon Hyung Hong
A novel CrFeMoVMnx high entropy alloy (HEA) system was devised after screening done with thermodynamic constraints. The Mn content was varied (x=0, 0.5, 1 atomic ratio), with other elements kept in equiatomic ratios, to determine the effect of paired sigma-forming element (PSFE) content on microstructural and mechanical behavior. Alloys were successfully fabricated using a powder metallurgical method after mechanical alloying (MA) for an optimized minimum milling time. The milled powder was sintered using spark plasma sintering (SPS). The microstructural analysis indicated the appearance of a σ phase in the equiatomic quinary CrFeMoVMnx system, and the volume fraction of the σ phase varied directly by Mn content. The Mn0 system exhibited the formation of a single phase solid solution. The failure of thermodynamic prediction, the role of PSFE content and Md¯ in σ phase appearance were investigated. The transition in mechanical behavior through a reduction in Mn content was also investigated and Mn1 exhibited the highest fracture strength, of 3183MPa, and hardness of 868 Hv, while Mn0 displayed the highest plasticity. This study demonstrates higher specific yield strength and hardness values compared to previously reported HEA systems.

Graphical abstract

http://ift.tt/2Czx2yp

Selective laser melting of stainless steel and alumina composite: Experimental and simulation studies on processing parameters, microstructure and mechanical properties

Publication date: 5 May 2018
Source:Materials & Design, Volume 145
Author(s): Xinwei Li, Habimana Jean Willy, Shuai Chang, Wanheng Lu, Tun Seng Herng, Jun Ding
Metal matrix composites (MMC) find their uses as high performance materials. The selective laser melting (SLM) of a 316L stainless steel and Al2O3 MMC is presented in this paper. Agglomerate Al2O3 particles had shown to be an adequate powder choice with uniform dispersions in the resultant prints. Relative density, phase, microstructure and mechanical properties of all 1-, 2-, 3-wt% doped products were carefully analyzed. Finite element modeling model was developed to study the associated multi-physics phenomena with high efficiency for process parameter optimization. It is found that the change in SLM temperature profile with Al2O3 addition is mainly due to the change in optical properties rather than thermal. Hence, both simulation and experimentation revealed that higher laser energy input is needed for optimized melting. In addition, cellular dendrites were found to coarsen with increasing Al2O3 addition due to the decreased cooling rate. With hard particle strengthening effects, all samples showed improved hardness with 3-wt% up to 298HV and 1-wt% samples showing much improved yielding and tensile stresses of 579 and 662MPa from 316L. Corresponding microlattice built this way demonstrated a 30 and 23% increase in specific strength and energy absorption from that of 316L too.

Graphical abstract

http://ift.tt/2HubNS5

Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED in in vitro culture model

Abstract

Activation of the Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis and hair growth. Recently, low-level laser therapy (LLLT) was evaluated for stimulating hair growth in numerous clinical studies, in which 655-nm red light was found to be most effective and practical for stimulating hair growth. We evaluated whether 655-nm red light + light-emitting diode (LED) could promote human hair growth by activating Wnt/β-catenin signaling. An in vitro culture of human hair follicles (HFs) was irradiated with different intensities of 655-nm red light + LED, 21 h7 (an inhibitor of β-catenin), or both. Immunofluorescence staining was performed to assess the expression of β-catenin, GSK3β, p-GSK3β, and Lef1 in the Wnt/β-catenin signaling. The 655-nm red light + LED not only enhanced hair shaft elongation, but also reduced catagen transition in human hair follicle organ culture, with the greatest effectiveness observed at 5 min (0.839 J/cm²). Additionally, 655-nm red light + LED enhanced the expression of β-catenin, p-GSK3β, and Lef1, signaling molecules of the Wnt/β-catenin pathway, in the hair matrix. Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED in vitro and therefore may serve as an alternative therapeutic option for alopecia.

http://ift.tt/2sLJOdc

Progressive osseous heteroplasia caused by a mosaic gnas mutation

Abstract

Progressive osseous heteroplasia (POH, OMIM#166350) is an "ultrarare" genetic condition characterized by plaque-like heterotopic ossification, beginning in infancy in the dermis and subsequently progressing to involve deep connective tissues such as muscles and joints, sometimes resulting in loss of mobility ¹. It is usually associated with paternal inheritance of an inactivating mutation at the GNAS gene but in some patients (around 30% of cases) with identical clinical characteristics of POH no mutations have been detected ². On the other hand, the same mutation on the paternal allele can be responsible for pseudopseudohypoparathyroidism (PPHP, OMIM#612463), or, if maternally inherited, pseudohypoparathyroidism type 1A (PHP1A, OMIM#103580) ^.

This article is protected by copyright. All rights reserved.

http://ift.tt/2EHKk1C

Accuracy of adrenal computed tomography in predicting the unilateral subtype in young patients with hypokalaemia and elevation of aldosterone in primary aldosteronism

Summary

Context

The current Endocrine Society Guideline suggests that patients aged <35 years with marked primary aldosteronism (PA) and unilateral adrenal lesions on adrenal computed tomography (CT) scan may not need adrenal vein sampling (AVS) before proceeding to unilateral adrenalectomy. This suggestion is, however, based on the data from only one report in the literature.

Objective

We sought to determine the accuracy of CT findings in young PA patients who had unilateral adrenal disease on CT with hypokalaemia and elevation of aldosterone.

Design and Patients

We retrospectively studied 358 PA patients (n=30, aged <35 years; n=39, aged 35-40 years; n=289, aged ≥40 years) with hypokalaemia and elevation of aldosterone and unilateral disease on CT who had successful AVS.

Main outcome measure

Accuracy of CT findings determined by AVS findings and/or surgical outcomes in patients aged <35 years.

Results

Concordance of the diagnosis between CT and AVS was 90% (27/30) in patients aged <35 years, 79% (31/39) in patients aged 35-40 years, and 69% (198/289) in those aged ≥40 years (Trend for p<0.01). Surgical benefit was confirmed in three patients aged <35 years and in three patients aged 35-40 years with available surgical data who had discordance between CT and AVS findings. Collectively, the diagnostic accuracy of CT findings was 100% (30/30) if aged <35 years and 87% (34/39) if aged 35-40 years.

Conclusion

PA patients aged <35 years with hypokalaemia and elevation of aldosterone and unilateral disease on adrenal CT could be spared AVS.

This article is protected by copyright. All rights reserved.

http://ift.tt/2BJA8CS

Copeptin role in polyuria-polydipsia syndrome (PPS) differential diagnosis and reference range in paediatric age

Summary

Objective

Plasma arginine-vasopressin (AVP) analysis can help in the differential diagnosis of the polyuria-polydipsia syndrome (PPS), even if such investigation is hampered by technical difficulties, conversely to its surrogate copeptin. This study aims to enlarge the existing data on normal copeptin levels in childhood, to evaluate the correlation between copeptin, serum sodium and plasma and urine osmolality, and to assess the utility of the copeptin analysis in the diagnostic work-up of PPS in the paediatric age.

Patients and methods

Plasma copeptin levels were evaluated in 53 children without AVP disorders (control population), in 12 hypopituitaric children and in 15 patients with PPS after water deprivation test (WDT).

Results

Mean basal copeptin levels were 5.2±1.56 (range 2.4-8.6 pmol/L) in the control population, 2.61±0.49 pmol/L in the hypopituitaric children with complete diabetes insipidus (CDI) (p=0.04), and 6.21±1.17 pmol/L in the hypopituitaric patients without DI (p=0.02). After WDT, among 15 naïve polyuric/polydipsic children copeptin values greater than 20 pmol/liter allowed to identify nephrogenic diabetes insipidus (NDI), concentrations below 2.2 pmol/liter complete central DI (CCDI) and between 5-20 pmol/l primary polydipsia (PP). Copeptin cut-off level of 3.5 pmol/l distinguished CDI from PP, with a sensitivity and specificity of 75% and 83.3%, respectively.

Conclusion

Copeptin evaluation holds promises as a diagnostic tool in paediatric PPS; its interpretation might be useful to promptly distinguish NDI, even avoiding the WDT need.

This article is protected by copyright. All rights reserved.

http://ift.tt/2C9g2mN

Heterozygous aggrecan variants are associated with short stature and brachydactyly: Description of 16 probands and a review of the literature

Summary

Objective

Mutations in the aggrecan gene (ACAN) have been identified in two autosomal dominant skeletal dysplasias, Spondyloepiphyseal dysplasia, Kimberley type (SEDK) and osteochondritis dissecans, as well as in a severe recessive dysplasia, Spondyloepimetaphyseal dysplasia, aggrecan type. Next generation sequencing (NGS) has aided the identification of heterozygous ACAN mutations in individuals with short stature, minor skeletal defects and mild facial dysmorphisms, some of whom have advanced bone age (BA), poor pubertal spurt and early growth cessation as well as precocious osteoarthritis.

Design & methods

Clinical and genetic characterization of 16 probands with heterozygous ACAN variants, 14 with short stature and mild skeletal defects (group 1) and two with SEDK (group 2). Subsequently, we reviewed the literature to determine the frequency of the different clinical characteristics in ACAN positive individuals.

Results

A total of 16 ACAN variants were located throughout the gene, six pathogenic mutations and 10 variants of unknown significance (VUS). Interestingly, brachydactyly was observed in all probands. Probands from group 1, with a pathogenic mutation tended to be shorter and 60% had an advanced BA compared to 0% in those with a VUS. A higher incidence of coxa valga was observed in individuals with a VUS (37% v 0%). Nevertheless, other features were present at similar frequencies.

Conclusions

ACAN should be considered as a candidate gene in patients with short stature and minor skeletal defects, particularly those with brachydactyly, and in patients with spondyloepiphyseal dysplasia. It is also important to note that advanced BA and osteoarticular complications are not obligatory conditions for aggrecanopathies/aggrecan-associated dysplasias.

This article is protected by copyright. All rights reserved.

http://ift.tt/2BG9b3e