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Τρίτη 15 Μαΐου 2018

Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα

Unklare schuppende und gerötete Hautveränderungen an den Palmae einer 53‐jährigen Frau

S Darr‐Foit, D Miguel, P Elsner, J Tittelbach - JDDG: Journal der Deutschen …, 2018
… oder Verbrennun- gen beschrieben [ 2–6 ] . Das klinische Bild erstreckt sich
über die Ausbildung einer akralen und perioralen Dermatitis, pus- tulösen,
bullösen und psoriasiformen Läsionen, einer gene- ralisierten Alopezie …
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[PDF] Cutaneous and Mucosal Manifestations Associated to Celiac Disease

L Rodrigo, VP Beteta, N Álvarez, CG de Castro… - 2018
Page 1. Review 1 Cutaneous and Mucosal Manifestations Associated to 2 Celiac Disease
3 Luis Rodrigo 1,*, Valia-Patricia Beteta 2, Nuria Álvarez 3, Celia Gómez de Castro 4, 4
Álvaro de Dios5, Laura Palacios6 and Jorge Santos-Juanes7 5 …
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Pancreatic Neuroendocrine Tumors (pNETs)

A Sanguinetti, A Polistena, LB Johnson, N Avenia - Surgical Management of Elderly …, 2018
… VIPoma. Watery diarrhea, hypokalemia, achlorhydria (WDHA syndrome).
Glucagonoma. Glucose intolerance, necrolytic migratory erythema,
stomatitis/glossitis, hypoaminoacidemia. Somatostatinoma …
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[HTML] Clinical, virological and epidemiological characterization of an outbreak of Testudinid Herpesvirus 3 in a chelonian captive breeding facility: Lessons learned and first …

ML Marenzoni, L Santoni, A Felici, C Maresca… - PloS one, 2018
… A number of TeHV-3 outbreaks have been investigated. However, several aspects of
the infection are still poorly understood [3, 9]. Clinical signs include conjunctivitis, nasal
and/or oral discharge, diphtheronecrotic stomatitis, glossitis, and pharyngitis …
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Compositions and methods relating to salts of specialized pro-resolving mediators

FC Sciavolino, G Mathias, MC Van Zandt… - US Patent App. 15/824,606, 2018
… In embodiments, the disease or disorder is an inflammatory disease or
disorder selected from asthma, ischemia reperfusion injury, lyme arthritis,
periodontitis, peritonitis, psoriasis, rheumatoid arthritis, scleroderma, oral …
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[HTML] Treatment of Oral Mucosal Lesions Associated With Overlapping Psychodermatologic Disorders

BDS Sausan Alfaris, K France, TP Sollecito…
… 12 In addition, adverse oral effects, such as xerostomia, dental caries, candidiasis, glossitis,
sialadenitis, and extrapyramidal movements of oral structures may be evident in patients
using antipsychotics, all of which may impact provision of oral healthcare. 12. Conclusion …
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[HTML] Echocardiography in Pediatric and Adult Congenital Heart Disease

R FEVER
… The diagnosis is based on clinical criteria (Table 25.6). Characteristic signs include fever
for 5 days, cracked lips, bilateral conjunctivitis, "strawberry tongue" (glossitis), cervical
lymphadenopathy, and desquamation of the hands and feet …
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[PDF] Oral rinse based cytology and exfoliative cytology–a comparative study in diabetic patients

NM Gayathry, B Sekar, M Ramesh, MJI Priyadarshini
… increased incidence of dental caries, gingivitis, periodontitis, periapical abcess, and parotid
enlargement, burning mouth syndrome, lichen planus, lichenoid reactions, traumatic ulcers,
irritational fibromas, glossodynia, median rhomboid glossitis, neurosensory dysesthesias …
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SILVADENE® CREAM

AP Point
… than 0.2%ofthe patienls orreported since the drug was mar- keted are listed
within each body system inorder ofdecreasing severity: Gastrointestinal-
pseudomembranous colitis(see WARNINGS), hemorrhagic colitis …
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Scholar : Laryngomalacia - νέα αποτελέσματα

[HTML] Anaesthetising an infant with acrocallosal syndrome: An unusual case

B Hosdurg, AP Nair, J Simha, S Sriramanan - Indian Journal of Anaesthesia, 2018
… In view of persistent respiratory distress and increased oral secretions,
the patient underwent fibreoptic laryngobronchoscopy in the Neonatal
Intensive Care Unit (NICU) and was found to have severe laryngomalacia …
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[HTML] Novel TFAP2A mutation in a Japanese family with Branchio-oculo-facial syndrome

T Sato, O Samura, N Kato, K Taniguchi, K Takahashi… - Human Genome Variation, 2018
… Laryngomalacia and tracheal dysplasia were also suspected. Following
ophthalmologic examination, he was diagnosed with bilateral colobomas, left
microphthalmia, and nasolacrimal duct obstruction. His karyotype was 46,XY …
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Perioperative and Anesthetic Considerations in Interrupted Aortic Arch

N Burbano-Vera, KL Zaleski, GJ Latham, VG Nasr - Seminars in cardiothoracic and …, 2018
Interrupted aortic arch (IAA) is defined as the loss of luminal continuity between the
ascending and descending aorta and is classified based on the anatomic le...
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Scholar : ΚΑΡΚΙΝΩΜΑ - νέα αποτελέσματα

[PDF] Διερεύνηση της υφιστάμενης κατάστασης στην άσκηση της φυτοπροστασίας του αστικού πρασίνου στους Δήμους

Ε Μαγγίνη - 2018
Page 1. ΓΕΩΠΟ Ο ΠΑ ΕΠ ΣΤΗ Ο ΑΘΗ Ω ΣΧΟ Η ΑΓΡΟΤ ΗΣ ΠΑΡΑΓΩΓΗΣ, ΥΠΟΔΟ Ω &
ΠΕΡ ΒΑ Ο ΤΟΣ Τ Η Α ΕΠ ΣΤΗ ΗΣ ΦΥΤ ΗΣ ΠΑΡΑΓΩΓΗΣ ΕΡΓΑΣΤΗΡ Ο ΓΕΩΡΓ ΗΣ ΦΑΡ
Α Ο ΟΓ ΑΣ Π..Σ.: ΕΠ ΣΤΗ ΕΣ Α ΣΥΣΤΗ ΑΤΑ ΦΥΤ ΗΣ ΠΑΡΑΓΩΓΗΣ …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.



Scholar : ΨΕΥΔΟΜΟΝΑΔΑ - νέα αποτελέσμα

[PDF] Φροντίδα εγκαυμάτων στην μονάδα εγκαυμάτων

Γ ΣΠΑΝΟΥ - 2018
Page 1. ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΔΥΤΙΚΗΣ ΕΛΛΑΔΑΣ
ΣΧΟΛΗ ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ ΚΑΙ ΠΡΟΝΟΙΑΣ ΤΜΗΜΑ ΝΟΣΗΛΕΥΤΙΚΗΣ
ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ Φροντίδα Εγκαυμάτων στην Μονάδα Εγκαυμάτων …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.



Scholar : ΠΡΟΣΩΠΙΚΟ ΝΕΥΡΟ - νέα αποτελέσματα

[PDF] Φροντίδα εγκαυμάτων στην μονάδα εγκαυμάτων

Γ ΣΠΑΝΟΥ - 2018
Page 1. ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΔΥΤΙΚΗΣ ΕΛΛΑΔΑΣ
ΣΧΟΛΗ ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ ΚΑΙ ΠΡΟΝΟΙΑΣ ΤΜΗΜΑ ΝΟΣΗΛΕΥΤΙΚΗΣ
ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ Φροντίδα Εγκαυμάτων στην Μονάδα Εγκαυμάτων …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.



Scholar : ΡΙΝΙΚΟ ΔΙΑΦΡΑΓΜΑ - νέα αποτελέσματα

[PDF] Buen vivir como alternativa al desarrollo: una construcción interdisciplinaria y participativa

N Greene, C Larrea, C Storini, FM López Parra - 2018
Page 1. UNIVERSIDAD ANDINA SIMÓN BOLÍVAR SEDE ECUADOR
COMITÉ DE INVESTIGACIONES INFORME DE INVESTIGACIÓN Buen
vivir como alternativa al desarrollo: una construcción interdisciplinaria y …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.



Structural identification of ZnxZryOz catalysts for Cascade aldolization and self-deoxygenation reactions

Publication date: 15 October 2018
Source:Applied Catalysis B: Environmental, Volume 234
Author(s): Rebecca A.L. Baylon, Junming Sun, Libor Kovarik, Mark Engelhard, Houqian Li, Austin D. Winkelman, Yong Wang
Complementary characterizations, such as nitrogen sorption, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), visible Raman, scanning transmission electron microscopy (STEM) coupled with elemental mapping, NH3/CO2 temperature programmed desorption (NH3/CO2-TPD), infrared spectroscopic analysis of adsorbed pyridine (Py-IR), and CO2-IR, have been employed to identify the structure and surface chemistry (i.e., acid-base) of mixed ZnxZryOz oxide catalysts of varied ratios of Zn/Zr. Atomically dispersed Zn2+ species are present in the framework within a thin surface shell (1.5–2.0 nm) of ZrO2 particles when the Zn/Zr ratio is smaller than 1/10; when the ratio is above this, both atomically dispersed Zn2+ and ZnO clusters coexist in mixed ZnxZryOz oxide catalysts. The presence of ZnO clusters shows no significant side effect but only a slight increase of selectivity to CO2, caused by steam reforming. The incorporation of atomic Zn2+ into the ZrO2 framework was found to not only passivate strong Lewis acid sites (i.e., Zr-O-Zr) on ZrO2, but to also generate new Lewis acid-base site pairs with enhanced Lewis basicity on the bridged O (i.e., ). In the mixed ketone (i.e., acetone and methyl ethyl ketone (MEK)) reactions, while the passivation of strong acid sites can be correlated to the inhibition of side reactions, such as ketone decomposition and coking, the new Lewis acid-base pairs introduced enhance the cascade aldolization and self-deoxygenation reactions involved in olefin (C3=-C6=) production. More importantly, the surface acid-base properties change with varying Zn/Zr ratios, which in turn affect the cross- and self-condensation reactivity and subsequent distribution of olefins.

Graphical abstract

image


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Brain state before a memory probe and associative retrieval in older adults

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Publication date: August 2018
Source:Neurobiology of Aging, Volume 68
Author(s): Jiangyi Xia, Giulia Galli, Leun J. Otten
Older individuals' difficulty in remembering events from a particular time and place may be explained by changes in retrieval-related control processes. We investigated how aging affects neural activity leading up to a retrieval probe and how such activity relates to later performance. Electrical brain activity was recorded while healthy younger and older humans memorized visual word pairs consisting of an object word (e.g., doll) preceded by a location word (e.g., garden). Only object words were presented during the memory test, the task being to decide whether an object had been presented earlier and, if so, what location had been paired with it. A warning signal before each test probe alerted to an upcoming object. A sustained negative-going event-related potential deflection preceded objects whose associated location could be remembered, especially in older individuals. The poorer an older individual's associative memory, the bigger was this deflection. Aging thus seems accompanied by changes in anticipatory brain states that relate to recollection. Such states may serve to mobilize control processes that aid the recovery of contextual details.



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A case of acrokeratoelastoidosis

Clinical and Experimental Dermatology, EarlyView.


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Δευτέρα 14 Μαΐου 2018

Technological behaviour in the early Acheulean of EF-HR (Olduvai Gorge, Tanzania)

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Publication date: Available online 27 April 2018
Source:Journal of Human Evolution
Author(s): Ignacio de la Torre, Rafael Mora
Technological strategies of early humans are discussed in the light of a recently excavated stone tool assemblage from EF-HR, an archaeological site older than 1.33 Ma at Olduvai Gorge, Tanzania. Renewed fieldwork at EF-HR has unearthed a lithic collection containing over 2300 artefacts (including a hundred handaxes in stratigraphic position), which represents one of the largest assemblages for the early Acheulean in East Africa. Our technological study shows co-occurrence of two distinctive reduction sequences in the same assemblage, one aimed at obtaining small flakes and the other focused on the production of large, thick, heavy flakes that were then used as blanks for handaxe shaping. Flaking of small cores is expedient and low intensity, and knapping methods are similar to those observed in earlier Oldowan assemblages. Large Cutting Tools (LCTs) show no evidence of planform and biconvex symmetry, and shaping sequences are brief and discontinuous, indicating short use-lives for handaxes. Bifaces are rare and atypical. Recurrent morphotypes are knives, which are poorly-shaped, scraper-like, large-sized handaxes. Despite the apparent expediency of EF-HR handaxe production, a closer inspection of the interplay between debitage and façonnage stages reveals remarkably standardized procedural patterns. Large Cutting Tool blanks were produced following fixed knapping rules resulting in flakes with a specific morphology and mass distribution. Adapted to the idiosyncrasies of each blank, shaping was almost invariably imposed over the same areas in all LCTs and sought to produce morphotypes that, technologically, are remarkably identical to each other. This strongly supports the existence of mental templates and technical rules that were systematically practiced in LCT production at EF-HR, and underscore the structured nature of technological behaviour at the onset of the Acheulean in East Africa.



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Editorial Board

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Publication date: June 2018
Source:Journal of Human Evolution, Volume 119





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Frank Brown (1943–2017)

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Publication date: June 2018
Source:Journal of Human Evolution, Volume 119
Author(s): Craig S. Feibel, Bernard Wood




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Patterns of lateral enamel growth in Homo naledi as assessed through perikymata distribution and number

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Publication date: Available online 27 April 2018
Source:Journal of Human Evolution
Author(s): Debbie Guatelli-Steinberg, Mackie C. O'Hara, Adeline Le Cabec, Lucas K. Delezene, Donald J. Reid, Matthew M. Skinner, Lee R. Berger
Perikymata, incremental growth lines visible on tooth enamel surfaces, differ in their distribution and number among hominin species, although with overlapping patterns. This study asks: (1) How does the distribution of perikymata along the lateral enamel surface of Homo naledi anterior teeth compare to that of other hominins? (2) When both perikymata distribution and number are analyzed together, how distinct is H. naledi from other hominins? A total of 19 permanent anterior teeth (incisors and canines) of H. naledi were compared, by tooth type, to permanent anterior teeth of other hominins: Australopithecus afarensis, Australopithecus africanus, Paranthropus robustus, Paranthropus boisei, Homo ergaster/Homo erectus, other early Homo, Neandertals, and modern humans, with varying sample sizes. Repeated measures analyses of the percentage of perikymata per decile of reconstructed crown height yielded several statistically significant differences between H. naledi and other hominins. Canonical variates analysis of percentage of perikymata in the cervical half of the crown together with perikymata number revealed that, in 8 of 19 cases, H. naledi teeth were significantly unlikely to be classified as other hominins, while exhibiting least difference from modern humans (especially southern Africans). In a cross-validated analysis, 68% of the H. naledi teeth were classified as such, while 32% were classified as modern human (most often southern African). Of 313 comparative teeth use for this analysis, only 1.9% were classified as H. naledi. What tends to differentiate H. naledi anterior tooth crowns from those of most other hominins, including some modern humans, is strongly skewed perikymata distributions combined with perikymata numbers that fall in the middle to lower ranges of hominin values. H. naledi therefore tends toward a particular combination of these features that is less often seen in other hominins. Implications of these data for the growth and development of H. naledi anterior teeth are considered.



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Mesopithecus pentelicus from the Turolian locality of Kryopigi (Kassandra, Chalkidiki, Greece)

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Publication date: Available online 10 May 2018
Source:Journal of Human Evolution
Author(s): Georgios Lazaridis, Evangelia Tsoukala, Todd C. Rae, Asier Gómez-Olivencia, Doris Nagel, Antonis Bartsiokas
New material of the Mio-Pliocene colobine Mesopithecus from the Turolian locality of Kryopigi (Greece) is described here. It includes a complete skull with the atlas attached and other dental and postcranial elements representing at least five individuals (four males and one female). The material is compared with Mesopithecus delsoni, Mesopithecus pentelicus, Mesopithecus monspessulanus and intermediate forms from more than a dozen Turolian localities of the Greco-Iranian province. These comparisons support the attribution of the Kryopigi material to M. pentelicus. The chronostratigraphic distribution of Mesopithecus species and intermediate forms suggests that the Kryopigi fauna could be dated as younger than the Perivolaki locality with M. delsoni/pentelicus (7.1–7.3 Ma, MN12) and older than the Dytiko localities with M. aff. pentelicus, M. cf. pentelicus and M. cf. monspessulanus (?middle MN13). The dimensions of the atlas are within the distribution of extant colobines. The skull shows bite-marks, probably caused by the hyaena Adcrocuta eximia.



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Reevaluation of ‘endocostal ossifications’ on the Kebara 2 Neanderthal ribs

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Publication date: Available online 10 May 2018
Source:Journal of Human Evolution
Author(s): Daniel García-Martínez, Manuel Campo Martín, Armando González Martín, Óscar Cambra-Moo, Alon Barash, Markus Bastir




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The effect of ontogeny on estimates of KNM-WT 15000's adult body size

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Publication date: Available online 10 May 2018
Source:Journal of Human Evolution
Author(s): Deborah L. Cunningham, Ronda R. Graves, Daniel J. Wescott, Robert C. McCarthy
The Homo erectus specimen KNM-WT 15000 has played a critical role in our understanding of body size evolution. New interpretations suggest that KNM-WT 15000 had a younger age-at-death and a more rapid ontogenetic trajectory than previously suggested. Recent fossil discoveries and new interpretations suggest a wide range of body size and shape variation in H. erectus. Based on these new insights, we argue that KNM-WT 15000's adult stature and body mass could have been much smaller than has been traditionally presented in the literature. Using chimpanzee and modern human growth trajectories, we bracketed the range of possibilities for KNM-WT 15000's adult body size between 160.0 and 177.7 cm (5′3″–5′10″) for stature and 60.0 and 82.7 kg (132–182 lbs.) for body mass. These estimates put KNM-WT 15000 near the mean rather than among the largest known H. erectus specimens.



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A new tephrochronology for early diverse stone tool technologies and long-distance raw material transport in the Middle to Late Pleistocene Kapthurin Formation, East Africa

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Publication date: Available online 10 May 2018
Source:Journal of Human Evolution
Author(s): Nick Blegen, Brian R. Jicha, Sally McBrearty
The Middle to Late Pleistocene (780–10 ka) of East Africa records evidence of significant behavioral change, early fossils of Homo sapiens, and the dispersals of our species across and out of Africa. Studying human evolution in this time period thus requires an extensive and precise chronology relating behavioral evidence from archaeological sequences to aspects of hominin biology and evidence of past environments from fossils and geological sequences. Tephrochronology provides the chronostratigraphic resolution to achieve this through correlation and dating of volcanic ashes. The tephrochronology of the Kapthurin Formation presented here, based on tephra correlations and 40Ar/39Ar dates, provides new ages between 395.6 ± 3.5 ka and 465.3 ± 1.0 ka for nine sites showing diverse blade and Levallois methods of core reduction. These are >110 kyr older than previously known in East Africa. New 40Ar/39Ar dates provide a refined age of 222.5 ± 0.6 ka for early evidence of long-distance (166 km) obsidian transport at the Sibilo School Road Site. A tephra correlation between the Baringo and Victoria basins also provides a new date of ∼100 ka for the Middle Stone Age site of Keraswanin. By providing new and older dates for 11 sites containing several important aspects of hominin behavior and extending the chronology of the Kapthurin Formation forward by ∼130,000 years, the tephrochronology presented here contributes one of the longest and most refined chronostratigraphic frameworks of Middle through Late Pleistocene East Africa. This tephrochronology thus provides the foundation to understand the process of modern human behavioral evolution as it relates to biological and paleoenvironmental circumstances.



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From the Oldowan to the Acheulean at Olduvai Gorge, Tanzania – An introduction to the special issue

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Publication date: Available online 10 May 2018
Source:Journal of Human Evolution
Author(s): Ignacio de la Torre, Lindsay McHenry, Jackson Njau




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Was the last common ancestor aping a chimp or just monkeying around?

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Publication date: Available online 9 May 2018
Source:Journal of Human Evolution
Author(s): Scott A. Williams




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Human-like hip joint loading in Australopithecus africanus and Paranthropus robustus

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Publication date: Available online 27 April 2018
Source:Journal of Human Evolution
Author(s): Timothy M. Ryan, Kristian J. Carlson, Adam D. Gordon, Nina Jablonski, Colin N. Shaw, Jay T. Stock
Adaptations indicative of habitual bipedalism are present in the earliest recognized hominins. However, debate persists about various aspects of bipedal locomotor behavior in fossil hominins, including the nature of gait kinematics, locomotor variability across different species, and the degree to which various australopith species engaged in arboreal behaviors. In this study, we analyze variation in trabecular bone structure of the femoral head using a sample of modern humans, extant non-human hominoids, baboons, and fossil hominins attributed to Australopithecus africanus, Paranthropus robustus, and the genus Homo. We use μCT data to characterize the fabric anisotropy, material orientation, and bone volume fraction of trabecular bone to reconstruct hip joint loading conditions in these fossil hominins. Femoral head trabecular bone fabric structure in australopiths is more similar to that of modern humans and Pleistocene Homo than extant apes, indicating that these australopith individuals walked with human-like hip kinematics, including a more limited range of habitual hip joint postures (e.g., a more extended hip) during bipedalism. Our results also indicate that australopiths have robust femoral head trabecular bone, suggesting overall increased loading of the musculoskeletal system comparable to that imposed by extant apes. These results provide new evidence of human-like bipedal locomotion in Pliocene hominins, even while other aspects of their musculoskeletal systems retain ape-like characteristics.



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A biplanar X-ray approach for studying the 3D dynamics of human track formation

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Publication date: Available online 9 May 2018
Source:Journal of Human Evolution
Author(s): Kevin G. Hatala, David A. Perry, Stephen M. Gatesy
Recent discoveries have made hominin tracks an increasingly prevalent component of the human fossil record, and these data have the capacity to inform long-standing debates regarding the biomechanics of hominin locomotion. However, there is currently no consensus on how to decipher biomechanical variables from hominin tracks. These debates can be linked to our generally limited understanding of the complex interactions between anatomy, motion, and substrate that give rise to track morphology. These interactions are difficult to study because direct visualization of the track formation process is impeded by foot and substrate opacity. To address these obstacles, we developed biplanar X-ray and computer animation methods, derived from X-ray Reconstruction of Moving Morphology (XROMM), to analyze the 3D dynamics of three human subjects' feet as they walked across four substrates (three deformable muds and rigid composite panel). By imaging and reconstructing 3D positions of external markers, we quantified the 3D dynamics at the foot-substrate interface. Foot shape, specifically heel and medial longitudinal arch deformation, was significantly affected by substrate rigidity. In deformable muds, we found that depths measured across tracks did not directly reflect the motions of the corresponding regions of the foot, and that track outlines were not perfectly representative of foot size. These results highlight the complex, dynamic nature of track formation, and the experimental methods presented here offer a promising avenue for developing and refining methods for accurately inferring foot anatomy and gait biomechanics from fossil hominin tracks.



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New hominin postcranial remains from locality OMO 323, Shungura Formation, Lower Omo Valley, southwestern Ethiopia

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Publication date: Available online 27 April 2018
Source:Journal of Human Evolution
Author(s): Guillaume Daver, Gilles Berillon, Caroline Jacquier, Yann Ardagna, Meklit Yadeta, Tiphaine Maurin, Antoine Souron, Cécile Blondel, Yves Coppens, Jean-Renaud Boisserie




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Large mammal diets and paleoecology across the Oldowan–Acheulean transition at Olduvai Gorge, Tanzania from stable isotope and tooth wear analyses

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Publication date: Available online 8 May 2018
Source:Journal of Human Evolution
Author(s): Kevin T. Uno, Florent Rivals, Faysal Bibi, Michael Pante, Jackson Njau, Ignacio de la Torre
The well-dated Pleistocene sediments at Olduvai Gorge have yielded a rich record of hominin fossils, stone tools, and vertebrate faunal remains that, taken together, provide insight to hominin behavior and paleoecology. Since 2008, the Olduvai Geochronology and Archaeology Project (OGAP) has undertaken extensive excavations in Bed II that have yielded a large collection of early Pleistocene stone tools and fossils. The strata of Lower, Middle and Upper Bed II at Olduvai Gorge capture the critical transition from Oldowan to Acheulean technology and therefore provide an opportunity to explore the possible role of biotic and abiotic change during the transition. Here, we analyze newly discovered and existing fossil teeth from Bed II sites using stable isotope and tooth wear methods to investigate the diets of large mammals. We reconstruct the dietary ecology of Bed II mammals and evaluate whether vegetation or hydroclimate shifts are associated with the technological change. Combined isotope and tooth wear data suggest most mammals were C4 grazers or mixed feeders. Carbon isotope data from bulk enamel samples indicate that a large majority of Bed II large mammals analyzed had diets comprising mostly C4 vegetation (>75% of diet), whereas only a small number of individuals had either mixed C3–C4 or mostly C3 diets (<25% C4). Mesowear generally indicates an increase of the abrasiveness of the diet between intervals IIA and IIB (∼1.66 Ma), probably reflecting increased grazing. Microwear indicates more abrasive diets in interval IIA suggesting stronger seasonal differences at the time of death during this interval. This is also supported by the intratooth isotope profiles from Equus oldowayensis molars, which suggest a possible decrease in seasonality across the transition. Neither stable isotope nor tooth wear analyses indicate major vegetation or hydrological change across the Oldowan–Acheulean transition.



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Reconstruction, endocranial form and taxonomic affinity of the early Homo calvaria KNM-ER 42700

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Publication date: Available online 26 April 2018
Source:Journal of Human Evolution
Author(s): Simon Neubauer, Philipp Gunz, Louise Leakey, Meave Leakey, Jean-Jacques Hublin, Fred Spoor
When first described, the small calvaria KNM-ER 42700 from Ileret, Kenya, was considered a late juvenile or young adult and assigned to Homo erectus. However, this species attribution has subsequently been challenged because the specimen's neurocranial shape differs substantially from that of H. erectus adults. Here, (1) we describe the postmortem damage and deformation that could have influenced previous shape analyses, (2) present digital reconstructions based on computed tomographic scans correcting for these taphonomic defects, and (3) analyze the reconstructed endocranial shape and form, considering both static allometry among adults and ontogenetic allometry. To this end, we use geometric morphometrics to analyze the shape of digital endocasts based on landmarks and semilandmarks. Corroborating previous studies of the external surface, we find that the endocranial shape of KNM-ER 42700 falls outside the known adult variation of H. erectus. With an endocranial volume estimate between 721 and 744 ml, size cannot explain its atypical endocranial shape when static allometry within H. erectus is considered. However, the analysis of ontogenetic allometry suggests that it may be a H. erectus individual that is younger than previously thought and had not yet reached adult endocranial shape. Future work should therefore comprehensively review all cranial indicators of its developmental age, including closure of the spheno-occipital synchondrosis. An alternative hypothesis is that KNM-ER 42700 represents an as yet unidentified species of early Homo. Importantly, KNM-ER 42700 should not be included in the adult hypodigm of H. erectus.



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Is there a Developed Oldowan A at Olduvai Gorge? A diachronic analysis of the Oldowan in Bed I and Lower-Middle Bed II at Olduvai Gorge, Tanzania

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Publication date: Available online 8 May 2018
Source:Journal of Human Evolution
Author(s): Tomos Proffitt
Debates regarding the validity of the Developed Oldowan as separate cultural facies within the Oldowan techno-complex have primarily concentrated on the Developed Oldowan B/Acheulean transition, with little attention paid to the validity of the Developed Oldowan A (DOA) as a valid technological differentiation. This study presents a diachronic technological analysis and comparison of Oldowan and DOA lithic assemblages from Olduvai Gorge, Tanzania, dated between 1.84 and 1.6 Ma, to test the validity of Leakey's original distinction between these two cultural facies. The results from this comparative analysis show very few technological differences between the lithic assemblages previously assigned to the DOA and Classic Oldowan. Significant diachronic variation in raw material availability and use is, however, identified between Bed I and Lower/Middle Bed II of Olduvai Gorge, which may go some way to explaining the originally perceived techno-cultural differences. The results suggest an increase in hominin knapping and percussive activities, as well as a clear ability to preferentially select high quality raw materials stratigraphically above Tuff IF. Technological innovation and complexity, however, does not seem to vary significantly between the Classic Oldowan and DOA assemblages. The results of this analysis along with similar studies from the wider eastern African region lead to the conclusion that the term Developed Oldowan A should no longer be used.



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The costs of living at the edge: Seasonal stress in wild savanna-dwelling chimpanzees

Publication date: Available online 21 April 2018
Source:Journal of Human Evolution
Author(s): Erin G. Wessling, Hjalmar S. Kühl, Roger Mundry, Tobias Deschner, Jill D. Pruetz
Adaptations associated with shifting from a predominately forested habitat to a more open environment are considered a crucial step in hominin evolution. Understanding how chimpanzees, one of our closest-living relatives, are exposed to the selection pressures associated with living in a relatively sparse, hot, and dry environment can inform us about the relative importance of potential environmental stressors involved in adaptations to drier environments. We investigated the extent to which chimpanzees living in an extreme savanna habitat experience seasonal variability in either energy balance or thermoregulation (dehydration and heat exposure), as well as whether these potential environmental constraints are taxing to chimpanzee individuals. Specifically, we tested the hypothesis that savanna environments impose seasonally-relevant costs to chimpanzees. To this end, we collected 368 urine samples from one community of chimpanzees at Fongoli, Senegal, and measured c-peptide, creatinine, and cortisol as measures of physiological responses to environmental food, water, and heat constraints, respectively. We then evaluated the influence of climatic and phenological factors on these indicators. Results illustrated significant seasonal variation in all biomarkers, which corresponded to relevant ecological correlates. Furthermore, creatinine but not c-peptide correlated with cortisol levels, suggesting that chimpanzees in this environment endure periods of heat and dehydration stress, but are able to avoid stressful levels of negative energy balance. Using savanna chimpanzees as a referential model, our research lends support to the notion that thermoregulatory challenges were a significant factor in hominin evolution, and suggests these challenges may have overshadowed the challenges of maintaining adequate energetic balance during the expansion of the hominin range from wetter to drier environments.



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Mandibular ramus shape variation and ontogeny in Homo sapiens and Homo neanderthalensis

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Publication date: Available online 30 April 2018
Source:Journal of Human Evolution
Author(s): Claire E. Terhune, Terrence B. Ritzman, Chris A. Robinson
As the interface between the mandible and cranium, the mandibular ramus is functionally significant and its morphology has been suggested to be informative for taxonomic and phylogenetic analyses. In primates, and particularly in great apes and humans, ramus morphology is highly variable, especially in the shape of the coronoid process and the relationship of the ramus to the alveolar margin. Here we compare ramus shape variation through ontogeny in Homo neanderthalensis to that of modern and fossil Homo sapiens using geometric morphometric analyses of two-dimensional semilandmarks and univariate measurements of ramus angulation and relative coronoid and condyle height. Results suggest that ramus, especially coronoid, morphology varies within and among subadult and adult modern human populations, with the Alaskan Inuit being particularly distinct. We also identify significant differences in overall anterosuperior ramus and coronoid shapes between H. sapiens and H. neanderthalensis, both in adults and throughout ontogeny. These shape differences are subtle, however, and we therefore suggest caution when using ramus morphology to diagnose group membership for individual specimens of these taxa. Furthermore, we argue that these morphologies are unlikely to be representative of differences in masticatory biomechanics and/or paramasticatory behaviors between Neanderthals and modern humans, as has been suggested by previous authors. Assessments of ontogenetic patterns of shape change reveal that the typical Neanderthal ramus morphology is established early in ontogeny, and there is little evidence for divergent postnatal ontogenetic allometric trajectories between Neanderthals and modern humans as a whole. This analysis informs our understanding of intraspecific patterns of mandibular shape variation and ontogeny in H. sapiens and can shed further light on overall developmental and life history differences between H. sapiens and H. neanderthalensis.



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An anti-NMDA receptor encephalitis mimicking an HIV encephalitis

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Publication date: Available online 14 May 2018
Source:Clinical Immunology
Author(s): Fatiha Haneche, Sophie Demeret, Dimitri Psimaras, Christine Katlama, Valérie Pourcher
The incidence of HIV associated neurocognitive disorders (HAND) were reduced with the use of antiretroviral therapy. In case of neuropsychiatric symptoms, after elimination of all infections, auto-immune encephalitis could be evocated as a differential diagnosis. We describe a case of anti-N-Methyl-d-Aspartate receptor encephalitis in an HIV-1 infected woman.



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Aortic Stenosis: Then and Now.

Author: Braunwald, Eugene MD
Page: 2099-2100


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Natriuretic Peptide-Guided Heart Failure Therapy After the GUIDE-IT Study.

Author: Januzzi, James L. Jr.; Richards, A. Mark MD, PhD
Page: 2101-2103


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Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests.

Author: Pollack, Ross A. BS; Brown, Siobhan P. PhD; Rea, Thomas MD, MPH; Aufderheide, Tom MD; Barbic, David MD; Buick, Jason E. MSc; Christenson, Jim MD; Idris, Ahamed H. MD; Jasti, Jamie BS; Kampp, Michael BS; Kudenchuk, Peter MD; May, Susanne PhD; Muhr, Marc EMT-P; Nichol, Graham MD, MPH; Ornato, Joseph P. MD; Sopko, George MD, MPH; Vaillancourt, Christian MD, MSc; Morrison, Laurie MD, MSc; Weisfeldt, Myron MD; the ROC Investigators
Page: 2104-2113


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Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: Prospective Multicenter Protocol-Directed Cohort Study.

Author: Roberts, Brian W. MD; Kilgannon, J. Hope MD; Hunter, Benton R. MD; Puskarich, Michael A. MD; Pierce, Lisa BA; Donnino, Michael MD; Leary, Marion RN, MPH, MSN; Kline, Jeffrey A. MD; Jones, Alan E. MD; Shapiro, Nathan I. MD, MPH; Abella, Benjamin S. MD, MPhil; Trzeciak, Stephen MD, MPH
Page: 2114-2124


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Oxygen After Cardiac Arrest: Enough Is Enough?.

Author: McKenzie, Nicole F. MPH, PG Dip (Critical Care), B Nurs, RN; Dobb, Geoffrey J. BSc, MB BS, FRCP, FRCA, FANZCA, FCICM
Page: 2125-2127


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Hospital Variation in Adherence Rates to Secondary Prevention Medications and the Implications on Quality.

Author: Mathews, Robin MD; Wang, William BS; Kaltenbach, Lisa A. MS; Thomas, Laine PhD; Shah, Rashmee U. MD, MS; Ali, Murtuza MD; Peterson, Eric D. MD, MPH; Wang, Tracy Y. MD, MHS, MSc
Page: 2128-2138


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Accounting for Nonadherence.

Author: Spatz, Erica S. MD; MHS; Curtis, Jeptha P. MD
Page: 2139-2141


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Six-Year Changes in Physical Activity and the Risk of Incident Heart Failure: ARIC Study.

Author: Florido, Roberta MD; Kwak, Lucia MS; Lazo, Mariana MD, PhD, ScM; Nambi, Vijay MD, PhD; Ahmed, Haitham M. MD, MPH; Hegde, Sheila M. MD; Gerstenblith, Gary MD; Blumenthal, Roger S. MD; Ballantyne, Christie M. MD; Selvin, Elizabeth PhD, MPH; Folsom, Aaron R. MD, MPH; Coresh, Josef MD, PhD; Ndumele, Chiadi E. MD, PhD
Page: 2142-2151


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Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration.

Author: Natarajan, Niranjana PhD; Abbas, Yamen BS; Bryant, Donald M. PhD; Gonzalez-Rosa, Juan Manuel PhD; Sharpe, Michka BS; Uygur, Aysu PhD; Cocco-Delgado, Lucas H.; Ho, Nhi Ngoc BS; Gerard, Norma P. PhD; Gerard, Craig J. MD, PhD; MacRae, Calum A. MD; Burns, Caroline E. PhD; Burns, C. Geoffrey PhD; Whited, Jessica L. PhD; Lee, Richard T. MD
Page: 2152-2165


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Socioeconomic Status and Cardiovascular Outcomes: Challenges and Interventions.

Author: Schultz, William M. MD; Kelli, Heval M. MD; Lisko, John C. MD; Varghese, Tina MD; Shen, Jia MD; Sandesara, Pratik MD; Quyyumi, Arshed A. MD; Taylor, Herman A. MD; Gulati, Martha MD; Harold, John G. MD; Mieres, Jennifer H. MD; Ferdinand, Keith C. MD; Mensah, George A MD; Sperling, Laurence S. MD
Page: 2166-2178


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Effect of Liraglutide on Cardiovascular Events in Patients With Type 2 Diabetes Mellitus and Polyvascular Disease: Results of the LEADER Trial.

Author: Verma, Subodh MD, PhD; Bhatt, Deepak L. MD, MPH; Bain, Stephen C. MD; Buse, John B. MD, PhD; Mann, Johannes F.E. MD; Marso, Steven P. MD; Nauck, Michael A. MD; Poulter, Neil R. FMedSci; Pratley, Richard E. MD; Zinman, Bernard MD; Michelsen, Marie M. MD; Monk Fries, Tea MD, PhD; Rasmussen, Soren MSc, PhD; Leiter, Lawrence A. MD; the LEADER Publication Committee on behalf of the LEADER Trial Investigators
Page: 2179-2183


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Letter by Romeo et al Regarding Article, "Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study".

Author: Romeo, Jamie L.R. MSc; Bogers, Ad J.J.C. MD, PhD; Mokhles, Mostafa M. MD, PhD
Page: 2184-2185


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Response by Heng et al to Letter Regarding Article, "Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study".

Author: Heng, Ee Ling MBBS, BSc, PhD; Diller, Gerhard-Paul MD, PhD; Gatzoulis, Michael A. MD, PhD; Babu-Narayan, Sonya V. MBBS, BSc, PhD
Page: 2186-2187


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Letter by Adabag et al Regarding Article, "Age and Outcomes of Primary Prevention Implantable Cardioverter-Defibrillators in Patients With Nonischemic Systolic Heart Failure".

Author: Adabag, Selcuk MD, MS; Wininger, Michael PhD; Singh, Steve N. MD
Page: 2188-2189


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Response by Elming et al to Letter Regarding Article, "Age and Outcomes of Primary Prevention Implantable Cardioverter-Defibrillators in Patients With Nonischemic Systolic Heart Failure".

Author: Elming, Marie Bayer MD; Signorovitch, James PhD; Kober, Lars MD, DMSc; Thune, Jens Jakob MD, PhD
Page: 2190


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Letter by Koshy et al Regarding Article, "Assessment of Remote Heart Rhythm Sampling Using the AliveCor Heart Monitor to Screen for Atrial Fibrillation: The REHEARSE-AF Study".

Author: Koshy, Anoop N. MBBS; Sajeev, Jithin K. MBChB; Teh, Andrew W. MBBS, PhD
Page: 2191-2192


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Response by Halcox and Wareham to Letter Regarding Article, "Assessment of Remote Heart Rhythm Sampling Using the AliveCor Heart Monitor to Screen for Atrial Fibrillation: The REHEARSE-AF Study".

Author: Halcox, Julian P.J. MD; Wareham, Kathie RN
Page: 2193-2194


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Letter by Koh Regarding Article, "Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study".

Author: Koh, Kwang Kon MD, PhD
Page: 2195-2196


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Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association.

Author: Konstam, Marvin A. MD, Chair; Kiernan, Michael S. MD, MS, FAHA, Co-Chair; Bernstein, Daniel MD; Bozkurt, Biykem MD, PhD, FAHA; Jacob, Miriam MD; Kapur, Navin K. MD; Kociol, Robb D. MD, MS; Lewis, Eldrin F. MD, MPH, FAHA; Mehra, Mandeep R. MD; Pagani, Francis D. MD, PhD, FAHA; Raval, Amish N. MD, FAHA; Ward, Carey MD; On behalf of the American Heart Association Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; and Council on Cardiovascular Surgery and Anesthesia
Page: e578-e622


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Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association.

Author: Chen, Lin Y. MD, MS, FAHA, Chair; Chung, Mina K. MD, FAHA, Vice Chair; Allen, Larry A. MD, MHS, FAHA; Ezekowitz, Michael MBChB, DPhil, FAHA; Furie, Karen L. MD, MPH, FAHA; McCabe, Pamela PhD, RN; Noseworthy, Peter A. MD; Perez, Marco V. MD; Turakhia, Mintu P. MD, MAS; On behalf of the American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council
Page: e623-e644


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Effects of ceftriaxone-induced intestinal dysbacteriosis on regulatory T cells validated by anaphylactic mice

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Publication date: July 2018
Source:International Immunopharmacology, Volume 60
Author(s): Xia Luo, Zengfeng Pan, Shuang Luo, Qi Liu, Shaowei Huang, Guanghua Yang, Feifei Nong, Yajun Fu, Xiangliang Deng, Lian Zhou
Both probiotics and pathogens in the human gut express pathogen-associated molecular patterns (PAMPs) and die with the release of endotoxin and bacterial DNA, which can stimulate our immune system and cause immune reaction. However, it's interesting and fascinating to address why the normal intestinal flora will not generate immunological rejection like the pathogen does. By investigating the changes in cells and molecules relevant to immune tolerance in mice with ceftriaxone-induced dysbacteriosis, our study discovered that both the Evenness indexes and Shannon Wiener index of intestinal flora showed a decrease in dysbacteriosis mice. Moreover, the proportion of αβ+TCR+CD3+CD4−CD8− cells, CD3+γδTCR+ cells and CD4+CD25+FoxP3+ cells in the Peyer's patches (PPs), mesenteric lymph nodes (MLNs) and spleen (SP) and the level of TGF-β1, IL-2, IL-4 and IL-10 in the serum also changed. Intestinal dysbacteriosis in an asthma murine model resulted in enhancement of immunologic response to the allergen ovalbumin (OVA), which was an agent that aggravates asthma symptoms. In summary, it is integral to maintain a certain amount or variety of intestinal microflora for regulatory T cells to act in averting hypersensitivity.



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A systematic review on the frequency of BRCA promoter methylation in breast and ovarian carcinomas of BRCA germline mutation carriers: Mutually exclusive, or not?

Publication date: Available online 14 May 2018
Source:Critical Reviews in Oncology/Hematology
Author(s): Shoko Vos, Paul Joannes van Diest, Cathy Beatrice Moelans
BackgroundA considerable number of breast and ovarian carcinomas are due to underlying BRCA gene aberrations. Of these, BRCA germline mutations and BRCA promoter methylation are thought to be mutually exclusive, which could be exploited in clinical practice. However, this paradigm has not been studied extensively and systematically.ObjectiveTo systematically investigate to what extent BRCA promoter methylation has been reported in breast and ovarian carcinomas of BRCA germline mutation carriers.MethodsA comprehensive search on BRCA promoter methylation was performed in PubMed and Embase databases. Two authors independently selected studies, assessed study quality and extracted data according to PRISMA and QUADAS-2 guidelines.Results21 articles met the inclusion criteria. BRCA1 methylation was found in at least 10/276 (3,6%) breast and 2/174 (1,1%) ovarian carcinomas of BRCA germline mutation carriers, and BRCA2 methylation was found in at least 7/131 (5.3%) breast and 0/51 (0.0%) ovarian carcinomas of BRCA germline mutation carriers. Methylation frequencies varied between individual CpG sites. The selected studies showed important differences in methodology and performed in general a limited methylation and incomplete mutation analysis.ConclusionsBRCA methylation is rare in breast and ovarian carcinomas of BRCA germline mutation carriers, although the frequency of BRCA promoter methylation may be underestimated. This could have major implications for clinical practice, including referral for genetic testing and BRCAness analysis for treatment decision-making.



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Micropatterned biodegradable polyesters clicked with CQAASIKVAV promote cell alignment, directional migration, and neurite outgrowth

Publication date: Available online 13 May 2018
Source:Acta Biomaterialia
Author(s): Deteng Zhang, Sai Wu, Jianyong Feng, Yiyuan Duan, Dongming Xing, Changyou Gao
The interplay of microstructures and biological cues is critical to regulate the behaviors of Schwann cells (SCs) in terms of cellular spatial arrangement and directional migration as well as neurite orientation for bridging the proximal and distal stumps of the injured peripheral nervous system. In this study, stripe micropatterns having ridges/grooves of width 20/20 and 20/40 μm were fabricated on the surface of maleimide-functionalized biodegradable poly(ester carbonate) (P(LLA-MTMC)) films by the polydimethylsiloxane mold-pressing method, respectively. The laminin-derived CQAASIKVAV peptides end-capped with an –SH group were then grafted by the thiol-ene click reaction under mild conditions to obtain micropatterned and peptide-grafted films. SCs cultured on these films, especially on the 20/40-μm film, displayed faster and aligned adhesion as well as a larger number of elongated cells with a higher length-to-width (L/W) ratio along the stripe direction than those on the flat-pep film. The migration rate of SCs was significantly enhanced in parallel to the stripe direction with a large net displacement. The micropatterned and peptide-grafted films, especially the 20/40-μm film, could promote SC proliferation and nerve growth factor (NGF) secretion in a manner similar to that of the peptide-grafted planar film. Moreover, the neurites of rat pheochromocytoma 12 (PC12) cells sprouted along the ridges with a longer average length on the micropatterned and peptide-grafted films. The synergistic effect of physical patterns and biological cues was evaluated by considering the results of cell adhesion force; immunofluorescence staining of vinculin; fluorescence staining of F-actin and the nucleus; as well as gene expression of neural cadherin (NCAD), neurocan (NCAN), and myelin protein zero (P0).Statement of significanceThe interplay of microstructures and biological cues is critical to regulate the behaviors of Schwann cells (SCs) and nerve cells, and thereby the regeneration of peripheral nerve system. In this study, the combined micropatterning and CQAASIKVAV grafting endowed the modified P(LLA-MTMC) films with both contact guidance and bioactive chemical cues to enhance cell proliferation, directional alignment and migration, longer net displacement and larger NGF secretion, and stronger neurite outgrowth of SCs and PC12 cells. Hence, the integration of physical micropatterns and bioactive molecules is an effective way to obtain featured biomaterials for the regeneration of nerves and other types of tissues.

Graphical abstract

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VideoEndocrinology™ High-Impact Videos

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VideoEndocrinology™
The Official Journal of: American Thyroid Association

FREE ACCESS through May 28, 2018.
Watch now:

Postoperative Continuous Pressure Monitoring in Thyroid Surgery: Pathophysiology of Post-Thyroidectomy Hemorrhage
Ulrich Wirth, Thomas von Ahnen, Stefan Schopf, Hans Martin Schardey 

Transaxillary Robotic Parathyroidectomy: Huge Parathyroid Adenoma
Patrick Aidan, Maroun Bechara  

Thyroid Fine-Needle Aspiration and Smearing Techniques
Mitsuyoshi Hirokawa, Ayana Suzuki, Akira Miyauchi

 

The post VideoEndocrinology™ High-Impact Videos appeared first on American Thyroid Association.



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Issue Information

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Molecular Oral Microbiology, Volume 33, Issue 3, Page i-iv, June 2018.


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