Scholar : Molecular Medicine Reports - Volume:18 Number:2

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TABLE OF CONTENTS August-2018 Volume 18 Issue 2

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Cell‑specific histone modifications in atherosclerosis (Review) Wanlin Jiang, Devendra K. Agrawal, Chandra S. Boosani View Abstract ❯
Computational approaches for predicting key transcription factors in targeted cell reprogramming (Review) Guillermo‑Issac Guerrero‑Ramirez, Cesar‑Miguel Valdez‑Cordoba, Jose‑Francisco Islas‑Cisneros, Victor Trevino View Abstract ❯
Efficacy prediction of targeted therapy for gastric cancer: The current status (Review) Wanjing Feng, Xiaodong Zhu View Abstract ❯
microRNA‑183 is involved in the differentiation and regeneration of Notch signaling‑prohibited hair cells from mouse cochlea Wei Zhou, Jintao Du, Di Jiang, Xianren Wang, Kaitian Chen, Haocheng Tang, Xuemei Zhang, Hui Cao, Ling Zong, Chang Dong, Hongyan Jiang View Abstract ❯
Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis Zhe Wang, Yudi Han, Zhaoqing Zhang, Cunfeng Jia, Qiang Zhao, Wei Song, Tao Chen, Yifan Zhang, Xiuhui Wang View Abstract ❯
Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non‑neoplastic mucosa Luoluo Yang, Xun Sun, Xiangwei Meng View Abstract ❯
miR‑339‑5p negatively regulates loureirin A‑induced hair follicle stem cell differentiation by targeting DLX5 Xiangjun Li, Yuqiong Wu, Fangfang Xie, Fengxue Zhang, Saixia Zhang, Jianhong Zhou, Dongfeng Chen, Aijun Liu View Abstract ❯
Inflammatory cytokine profile of co‑cultivated primary cells from the endometrium of women with and without endometriosis Adriana Luckow Invitti, Eduardo Schor, Rafael Martins Parreira, Alexander Kopelman, Gil Kamergorodsky, Giovana Aparecida Gonçalves, Manoel João Batista Castello Girão View Abstract ❯
System analysis of teratozoospermia mRNA profile based on integrated bioinformatics tools Tiancheng Zhang, Jun Wu, Caihua Liao, Zhong Ni, Jufen Zheng, Fudong Yu View Abstract ❯
CXCL9 promotes prostate cancer progression through inhibition of cytokines from T cells Shanfeng Tan, Kai Wang, Fuguang Sun, Yang Li, Yisheng Gao View Abstract ❯
Genes associated with inflammation and the cell cycle may serve as biomarkers for the diagnosis and prognosis of acute myocardial infarction in a Chinese population Jiang Su, Changqing Gao, Rong Wang, Cangsong Xiao, Ming Yang View Abstract ❯
Salvianolic acid B reverses multidrug resistance in nude mice bearing human colon cancer stem cells Piaoting Guo, Jianchao Wang, Wencang Gao, Xia Liu, Shaofei Wu, Boshun Wan, Lei Xu, Yanhua Li View Abstract ❯
Response of hPDLSCs on 3D printed PCL/PLGA composite scaffolds in vitro Caixia Peng, Jinxuan Zheng, Dongru Chen, Xueqin Zhang, Lidi Deng, Zhengyuan Chen, Liping Wu View Abstract ❯
Telomerase reverse transcriptase induced thyroid carcinoma cell proliferation through PTEN/AKT signaling pathway Hao Zhang, Ning Hu View Abstract ❯
Lipid raft‑associated β‑adducin participates in neutrophil migration Chen Yang, Zhefeng Sui, Tingshuang Xu, Wenai Liu, Xiaoguang Wang, Xianlu Zeng View Abstract ❯
Sipi soup inhibits cancer‑associated fibroblast activation and the inflammatory process by downregulating long non‑coding RNA HIPK1‑AS Bingxiu Zhou, Yuanyuan Yu, Lixia Yu, Binfu Que, Rui Qiu View Abstract ❯
Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function Sichao Zhang, Xi Chen, Ichinkhorloo Devshilt, Qi Yun, Cong Huang, Lijun An, Sosorburam Dorjbat, Xin He View Abstract ❯
Low expression of KCNN3 may affect drug resistance in ovarian cancer Xia Liu, Luwei Wei, Bingbing Zhao, Xiangxue Cai, Caihua Dong, Fuqiang Yin View Abstract ❯
The roles of the TLR/NF‑κB signaling pathway in the mutual interactions between the lung and the large intestine Wen Fu, Jing Zhao, Xinglong Liu, Yongxiang Gao, Chuan Zheng View Abstract ❯
miR‑141 inhibits glioma vasculogenic mimicry by controlling EphA2 expression Guoxiong Li, Min Huang, Yingqian Cai, Yiquan Ke, Yuantao Yang, Xinlin Sun View Abstract ❯
Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells Hongtao Sun, Shuiyun Wang, Min Song View Abstract ❯
Screening genes associated with elevated neutrophil‑to‑lymphocyte ratio in chronic heart failure Guoxing Wan, Lihua Ji, Wenbin Xia, Lan Cheng, Yonggang Zhang View Abstract ❯
A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review Minghui Pang, Yijun Liu, Xiaolin Hou, Jialiang Yang, Xuelai He, Nengyi Hou, Peixi Liu, Luo Liang, Junwen Fu, Kang Wang, Zimeng Ye, Bo Gong View Abstract ❯
Curcumin suppresses cardiac fibroblasts activities by regulating the proliferation and cell cycle via the inhibition of the p38 MAPK/ERK signaling pathway Guanhua Fang, Shaoqin Chen, Qiuyu Huang, Liangwan Chen, Dongshan Liao View Abstract ❯
Protective effect of crocin on ultraviolet B‑induced dermal fibroblast photoaging Mingwu Deng, Dong Li, Yichen Zhang, Guangdong Zhou, Wei Liu, Yilin Cao, Wenjie Zhang View Abstract ❯
Grape seed proanthocyanidins protect against streptozotocin‑induced diabetic nephropathy by attenuating endoplasmic reticulum stress‑induced apoptosis Zhaoli Gao, Guangyi Liu, Zhao Hu, Weiwei Shi, Binbin Chen, Peimei Zou, Xianhua Li View Abstract ❯
Physical exercise promotes proliferation and differentiation of endogenous neural stem cells via ERK in rats with cerebral infarction Wei Liu, Wen Wu, Guangyong Lin, Jian Cheng, Yanyan Zeng, Yu Shi View Abstract ❯
Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis Yang Zhang, Hui‑Xia Qiao, Yong‑Tao Zhou, Liang Hong, Ju‑Hui Chen View Abstract ❯
A three‑lncRNA signature for prognosis prediction of acute myeloid leukemia in patients Fangce Wang, Xiaoxue Tian, Jie Zhou, Guangming Wang, Wenlei Yu, Zheng Li, Zhuoyi Fan, Wenjun Zhang, Aibin Liang View Abstract ❯
Autophagy protects bone marrow mesenchymal stem cells from palmitate‑induced apoptosis through the ROS‑JNK/p38 MAPK signaling pathways Yongyi Liu, Ning Wang, Shaokun Zhang, Qingwei Liang View Abstract ❯
Alterations in β‑catenin/E‑cadherin complex formation during the mechanotransduction of Saos‑2 osteoblastic cells Fei‑Fei Li, Bo Zhang, Ji‑Hong Cui, Fu‑Lin Chen, Yin Ding, Xue Feng View Abstract ❯
Comprehensive evaluation of differential lncRNA and gene expression in patients with intervertebral disc degeneration Zhigang Qu, Zhe Quan, Qi Zhang, Zhenyu Wang, Qingxu Song, Xinming Zhuang, Changfeng Fu, Feng Xu, Yadong Liu, Yuanyi Wang, Zheng Wang, Yi Liu View Abstract ❯
Identification and functional analysis of differentially expressed genes associated with cerebral ischemia/reperfusion injury through bioinformatics methods Xiaoli Shao, Wangxiao Bao, Xiaoqin Hong, Huihua Jiang, Zhi Yu View Abstract ❯
miR‑23a downregulation modulates the inflammatory response by targeting ATG12‑mediated autophagy Xiang Si, Daiyin Cao, Juan Chen, Yao Nie, Zhiyi Jiang, Min‑Ying Chen, Jian‑Feng Wu, Xiang‑Dong Guan View Abstract ❯
A novel method to detect the Mexican founder mutation BRCA1 ex9‑12del associated with breast and ovarian cancer using quantitative polymerase chain reaction and TaqMan® probes Denisse Aideé Martínez‑Treviño, Rafael Baltazar Reyes León‑Cachón, Cynthia Villarreal‑Garza, Dione Aguilar Y Méndez, Elisa Aguilar‑Martínez, Hugo Alberto Barrera‑Saldaña View Abstract ❯
Identification of candidate biomarkers and pathways associated with SCLC by bioinformatics analysis Pushuai Wen, Tungamirai Chidanguro, Zhuo Shi, Huanyu Gu, Nan Wang, Tongmei Wang, Yuhong Li, Jing Gao View Abstract ❯
Proteomic profiling for plasma biomarkers of tuberculosis progression Qiuyue Liu, Liping Pan, Fen Han, Baojian Luo, Hongyan Jia, Aiying Xing, Qi Li, Zongde Zhang View Abstract ❯
Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway Zhengwen Zhou, Yue Zhang, Luning Lin, Jianmei Zhou View Abstract ❯
Overexpression of retinoblastoma‑binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3‑kinase/protein kinase B pathway suppression Xiaoxi Jin, Rui Jiang, Yongsheng Xiang, Zhen Fan, Zhiwei Wu, Bo Yang, Lujun Yang, Shanshan Wei, Yan Yang View Abstract ❯
Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway Lin Xu, Xuejun Jiang, Fang Wei, Hongling Zhu View Abstract ❯
miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11 Tianpeng Jiang, Zhi Huang, Shuai Zhang, Weijie Zou, Lei Xiang, Xiaowen Wu, Yaping Shen, Weixin Liu, Zhu Zeng, Ansu Zhao, Shi Zhou, Qingfan Zeng View Abstract ❯
Induction of apoptosis by Bigelovii A through inhibition of NF‑κB activity Fuqin Guan, Yu Shan, Qizhi Wang, Ming Wang, Yu Chen, Min Yin, Fei Liu, Youyi Zhao, Jianhua Zhang, Xu Feng View Abstract ❯
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF‑κB pathway in mouse kupffer cells Bailin Niu, Kun He, Peizhi Li, Jianping Gong, Xiwen Zhu, Shangmin Ye, Zhibing Ou, Guosheng Ren View Abstract ❯
Long noncoding RNA AFAP1‑AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR‑4695‑5p/TCF4‑β‑catenin signaling Rongrui Li, Shichen Liu, Yao Li, Qingxi Tang, Yunchuan Xie, Raosheng Zhai View Abstract ❯
Molecular analysis of Cypriot families with aniridia reveals a novel PAX6 mutation Andreas Syrimis, Nayia Nicolaou, Angelos Alexandrou, Ioannis Papaevripidou, Michael Nicolaou, Eleni Loukianou, Carolina Sismani, Stavros Malas, Violetta Christophidou‑Anastasiadou, George A. Tanteles View Abstract ❯
Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids Ye Zhang, Bingyu Guo, Qiang Hui, Wei Li, Peng Chang, Kai Tao View Abstract ❯
Pioglitazone restores the homocysteine‑impaired function of endothelial progenitor cells via the inhibition of the protein kinase C/NADPH oxidase pathway Junhui Zhu, Yanbo Zhao, Lu Yu, Meihui Wang, Qinfeng Li, Shengjie Xu View Abstract ❯
CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3 Ye Wu, Lei Tian, Yongle Xu, Minhong Zhang, Shengqing Xiang, Jianguo Zhao, Zhenxia Wang View Abstract ❯
Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma through regulation of the EGF‑mediated JAK‑STAT signaling pathway Mingli Duan, Xiaoming Du, Gang Ren, Yongdong Zhang, Yu Zheng, Shuping Sun, Jun Zhang View Abstract ❯
Efficacy of lentivirus‑mediated Drosophila melanogaster deoxyribonucleoside kinase combined with (E)‑5‑(2‑bromovinyl)‑2'‑deoxyuridine or 1‑β‑D‑arabinofuranosylthymine therapy in human keloid fibroblasts Yiqun Sun, Haiyang Jiang, Ming Gu, Xinyu Zheng View Abstract ❯
miRNA‑195 suppresses cell proliferation of ovarian cancer cell by regulating VEGFR2 and AKT signaling pathways Jun Chen View Abstract ❯
miR‑205 targets YAP1 and inhibits proliferation and invasion in thyroid cancer cells Dewei Li, Qiang Wang, Ning Li, Shuilong Zhang View Abstract ❯
Bushen recipe and its disassembled prescriptions inhibit inflammation of liver injury associated with Concanavalin A through Toll‑like receptor 3/9 signaling pathway Hongming Nie, Zhaohe Mei, Rong Wang, Binbin Zhao, Yueqiu Gao, Jianjie Chen, Lingtai Wang View Abstract ❯
Tanshinone IIA regulates colorectal cancer apoptosis via attenuation of Parkin‑mediated mitophagy by suppressing AMPK/Skp2 pathways Lili He, Kebo Gu View Abstract ❯
Increased B cell activating factor is associated with B cell class switching in patients with tuberculous pleural effusion Xin Wang, Kui‑Di Liang, Jun‑Ai Zhang, Gan‑Bin Liu, Zhi Chen, Chen Chen, Ze‑Gang Zhuang, Yu‑Qing Liu, Hou‑Long Luo, Rui Xi Li, Bi‑Ying Zheng, Jun‑Fa Xu View Abstract ❯
Hypoxia induces lactate secretion and glycolytic efflux by downregulating mitochondrial pyruvate carrier levels in human umbilical vein endothelial cells Dong Wang, Qingjie Wang, Gaoliang Yan, Yong Qiao, Boqian Zhu, Bo Liu, Chengchun Tang View Abstract ❯
Reduction in activating transcription factor 4 promotes carbon tetrachloride and lipopolysaccharide/D‑galactosamine‑mediated liver injury in mice Xiaofang Zhao, Hong Zhou, Ying Cheng, Wenjing Yu, Guosong Luo, Chunyan Duan, Fuli Yao, Bin Xiao, Chunhong Feng, Xianming Xia, Mei Wei, Yong Wang, Jing Li, Rongyang Dai View Abstract ❯
Association between age‑related hearing loss and cognitive decline in C57BL/6J mice Yang Dong, Chun‑Rong Guo, Dan Chen, Sheng‑Min Chen, Yinting Peng, Haiyan Song, Jian‑Rong Shi View Abstract ❯
Epithelial‑mesenchymal transition was identified as a potential marker for breast cancer aggressiveness using reverse transcription‑quantitative polymerase chain reaction Ulrich Andergassen, Kristina Schlenk, Udo Jeschke, Harald Sommer, Alexandra Kölbl View Abstract ❯
Effects of microRNA‑210 on the diagnosis and treatment of prostate cancer Yuejun Qu, Wenqiang Huang View Abstract ❯
Upregulation of miR‑122 is associated with cardiomyocyte apoptosis in atrial fibrillation Xiangqun Zhang, Wenli Jing View Abstract ❯
Protective effects of scoparone against ischemia‑reperfusion‑induced myocardial injury Chunfu Wan, Yueyue Wei, Jianguo Ma, Xiaoyong Geng View Abstract ❯
Novel HSPG2 mutations causing Schwartz‑Jampel syndrome type 1 in a Chinese family: A case report Wenjin Yan, Jin Dai, Dongquan Shi, Xingquan Xu, Xiao Han, Zhihong Xu, Dongyang Chen, Huajiang Teng, Qing Jiang View Abstract ❯
Integrated computational biology analysis to evaluate target genes for chronic myelogenous leukemia Yu Zheng, Yu‑Ping Wang, Hongbao Cao, Qiusheng Chen, Xi Zhang View Abstract ❯
Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs Changhwan Ahn, Jong‑Sam Choi, Eui‑Bae Jeung View Abstract ❯
TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling Qing‑Zhi Gu, Abulimiti Nijiati, Xing Gao, Kai‑Liang Tao, Cheng‑Duo Li, Xue‑Peng Fan, Zheng Tian View Abstract ❯
Glucagon‑like peptide‑1 protects mouse podocytes against high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in vitro Jian‑Xia Shi, Qin Huang View Abstract ❯
CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide P. Fallahi, R. Foddis, G. Elia, F. Ragusa, A. Patrizio, S. Benvenga, A. Cristaudo, A. Antonelli, S. M. Ferrari View Abstract ❯
MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R Yongquan Lin, Lihua Rong, Jingrong Zhao, Ronghui Lin, Shuhua Li View Abstract ❯
MicroRNA‑199b promotes cell proliferation and invasion in Wilms' tumour by directly targeting Runt‑related transcription factor 3 Huizhen Zhao, Hailing Zhao, Yongna Zhang, Yuxi Zhou View Abstract ❯
MG‑132 reverses multidrug resistance by activating the JNK signaling pathway in FaDu/T cells Juke Ma, Zhenghua Lv, Xiuxiu Liu, Xianfang Liu, Wei Xu View Abstract ❯
microRNA‑574 inhibits cell proliferation and invasion in glioblastoma multiforme by directly targeting zinc finger E‑box‑binding homeobox 1 Youyan Mao, Fangmeng Wei, Chenghong Wei, Chengjun Wei View Abstract ❯
Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines Yuanxin Zhang, Yakun Ge, Xie Ping, Ming Yu, Dawei Lou, Wei Shi View Abstract ❯
B7‑H1‑mediated immunosuppressive properties in human mesenchymal stem cells are mediated by STAT‑1 and not PI3K/Akt signaling In Keun Jang, Hyun Joo Jung, O Kyu Noh, Doo‑Hoon Lee, Kwang Chul Lee, Jun Eun Park View Abstract ❯
Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice Tianxiang Geng, Xi Chen, Mengxue Zheng, Haochen Yu, Shuai Zhang, Shouxuan Sun, Haohui Guo, Qunhua Jin View Abstract ❯
Protective effect of Letinous edodes foot peptides against ethanol‑induced liver injury in L02 cells Lin Ma, Chun‑Yan Huo, Xiao‑Yu Zhang, Chen‑Qiang Qin, Di‑Feng Ren, Jun Lu View Abstract ❯
Oxidative stress modulates the expression of toll‑like receptor 3 during respiratory syncytial virus infection in human lung epithelial A549 cells Min‑Min Wang, Min Lu, Chuan‑Long Zhang, Xuan Wu, Jing‑Xian Chen, Wei‑Wei Lv, Tao Sun, Huan Qiu, Sheng‑Hai Huang View Abstract ❯
MicroRNA‑655 inhibits cell proliferation and invasion in epithelial ovarian cancer by directly targeting vascular endothelial growth factor Ziling Zhao, Shuna Yang, Yan Cheng, Xiuhua Zhao View Abstract ❯
The effect of Mg‑2Zn‑0.5Nd alloy on the mTOR signalling pathway in L6 cells Wei Lu, Lei Guo, Tianlong Jiang, Shenghui Ni, Yuyan Zhao View Abstract ❯
[Corrigendum] Construction of a lentiviral vector containing shRNA targeting ADAM17 and its role in attenuating endotoxemia in mice Bing He, Xiaoou Li, Tuo Hu, Wenjing Lian, Mingxia Zhang View Abstract ❯
[Corrigendum] microRNA‑181a‑5p functions as an oncogene in renal cell carcinoma Yulin Lai, Liwen Zhao, Jia Hu, Jing Quan, Peijie Chen, Jinling Xu, Xin Guan, Yongqing Lai, Liangchao Ni View Abstract ❯
Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway Chengzhi Fang, Lili Xie, Chunmei Liu, Chunhua Fu, Wei Ye, Hong Liu, Binghong Zhang View Abstract ❯
MicroRNA expression profiles identify biomarkers for predicting the response to chemoradiotherapy in rectal cancer Binbin Du, Xiaoying Wang, Dewang Wu, Tao Wang, Xiongfei Yang, Jiankai Wang, Xinlong Shi, Lingjuan Chen, Weisheng Zhang View Abstract ❯
Regulatory effects of microRNA‑184 on osteosarcoma via the Wnt/β‑catenin signaling pathway Zhenguang Du, Fusheng Li, Liangliang Wang, Hai Huang, Shaonian Xu View Abstract ❯
Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats Dandan Song, Xuelei Liu, Yugang Diao, Yingjie Sun, Guangjie Gao, Tiezheng Zhang, Keyan Chen, Ling Pei View Abstract ❯
Effect of survivin downregulation by simvastatin on the growth and invasion of salivary adenoid cystic carcinoma Wen‑Yan Cai, Ying Zhuang, Fei Yan, Ting Li, Wen‑Ting Song, Jin‑Hu Sun View Abstract ❯
HBx gene transfection affects the cycle of primary renal tubular epithelial cells through regulating cyclin expression Wenlun Han, Meiliang Luo, Mengying He, Yunyun Zhu, Yu Zhong, Huideng Ding, Gang Hu, Liansheng Liu, Qin Chen, Ying Lu View Abstract ❯
Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium Nan Guo, Nan Zhang, Liqiu Yan, Zheng Lian, Jiawang Wang, Fengfeng Lv, Yunfei Wang, Xufen Cao View Abstract ❯
Detection of dysregulated competing endogenous RNA modules associated with clear cell kidney carcinoma Hong Wang, Dahua Xu, Huiying Huang, Ying Cui, Chunhua Li, Chunrui Zhang, Shengnan Guo, Lining Zhang, Xiaomu Xu, Jiankai Xu, Jianping Lu, Liqiang Wang, Kongning Li View Abstract ❯
Interaction with adipocytes induces lung adenocarcinoma A549 cell migration and tumor growth Fan-Fan Li, Hang Zhang, Jing-Jing Li, Ya-Nan Cao, Xiang Dong, Cong Gao View Abstract ❯
Antioxidants retard the ageing of mouse oocytes Yexing Xian, Lifeng Liang, Shutao Qi, Yingjun Xie, Bing Song, Shuming Ouyang, Yuhuan Xie, Xiaofang Sun, Weihua Wang View Abstract ❯
Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α Bing Liu, Lili Xu, Xinming Yu, Wei Li, Xiaozhi Sun, Shun Xiao, Mingjin Guo, Haofu Wang View Abstract ❯
Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy Yingchun Qiao, Xixi Tian, Li Men, Shengyu Li, Yufeng Chen, Meiting Xue, Yahui Hu, Pengfei Zhou, Guangfeng Long, Yue Shi, Ruiqing Liu, Yunde Liu, Zhi Qi, Yujie Cui, Yanna Shen View Abstract ❯
Differentiation of umbilical cord mesenchymal stem cells into hepatocytes in comparison with bone marrow mesenchymal stem cells Ya‑Bin Yu, Yan Song, Ya Chen, Feng Zhang, Fu‑Zhen Qi View Abstract ❯
Application of 460 nm visible light for the elimination of Candida albicans in vitro and in vivo Chuan Wang, Zhiyin Yang, Yinbo Peng, Yuanyuan Guo, Min Yao, Jiying Dong View Abstract ❯
Whole‑exome sequencing analysis of products of conception identifies novel mutations associated with missed abortion Meng Fu, Sha Mu, Chunyan Wen, Shufang Jiang, Lin Li, Yuanguang Meng, Hongmei Peng View Abstract ❯
Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis Takumi Kawaguchi, Dan Nakano, Tetsuharu Oriishi, Takuji Torimura View Abstract ❯
YC‑1 reduces inflammatory responses by inhibiting nuclear factor‑κB translocation in mice subjected to transient focal cerebral ischemia Wei‑Ting Lee, Shih‑Huang Tai, Yu‑Wen Lin, Tian‑Shung Wu, E‑Jian Lee View Abstract ❯
Expression of vitamin D receptor in bronchial asthma and its bioinformatics prediction Lishen Shan, Xinyuan Kang, Fen Liu, Xuxu Cai, Xiaohua Han, Yunxiao Shang View Abstract ❯
TIMP‑3 suppresses the proliferation and migration of SMCs from the aortic neck of atherosclerotic AAA in rabbits, via decreased MMP‑2 and MMP‑9 activity, and reduced TNF‑α expression Huan Zhai, Xun Qi, Zixuan Li, Wei Zhang, Chenguang Li, Lu Ji, Ke Xu, Hongshan Zhong View Abstract ❯
Antitumor effects of Xi Huang pills on MDA‑MB‑231 cells in vitro and in vivo Wenxian Zheng, Shuyan Han, Shantong Jiang, Xiran He, Xiaohong Li, Huirong Ding, Minhua Cao, Pingping Li View Abstract ❯
Label‑free quantitative proteomics and bioinformatics analyses of alcoholic liver disease in a chronic and binge mouse model Yu Zhang, Cheng Zhan, Genwen Chen, Jianyong Sun View Abstract ❯
Epigallocatechin gallate improves airway inflammation through TGF‑β1 signaling pathway in asthmatic mice Lishen Shan, Xinyuan Kang, Fen Liu, Xuxu Cai, Xiaohua Han, Yunxiao Shang View Abstract ❯
Characteristics and multi‑lineage differentiation of bone marrow mesenchymal stem cells derived from the Tibetan mastiff Shuang Zhang, Chenqiong Zhao, Shi Liu, Yufeng Wang, Yuhua Zhao, Weijun Guan, Zhiqiang Zhu View Abstract ❯
C5a aggravates dysfunction of the articular cartilage and synovial fluid in rats with knee joint immobilization Wei Lu, Lin Wang, Jing Yao, Chunxin Wo, Yu Chen View Abstract ❯
Amplification of bacterial genomic DNA from all ascitic fluids with a highly sensitive polymerase chain reaction Hirayuki Enomoto, Shin‑Ichi Inoue, Akio Matsuhisa, Yoshinori Iwata, Nobuhiro Aizawa, Yoshiyuki Sakai, Ryo Takata, Naoto Ikeda, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Kazunori Yoh, Yuho Miyamoto, Noriko Ishii, Yukihisa Yuri, Akio Ishii, Tomoyuki Takashima, Hiroki Nishikawa, Hiroko Iijima, Shuhei Nishiguchi View Abstract ❯
Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells Yan Yu, Wanting Li, Liqin Ren, Chunyan Yang, Dongze Li, Xin Han, Yeying Sun, Changjun Lv, Fang Han View Abstract ❯
Effect of electric stimulation on human chondrocytes and mesenchymal stem cells under normoxia and hypoxia Bettina Hiemer, Martin Krogull, Thomas Bender, Josefin Ziebart, Simone Krueger, Rainer Bader, Anika Jonitz‑Heincke View Abstract ❯
N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes Zuheng Liu, Jinghai Hua, Wanqiang Cai, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu View Abstract ❯
Identification of differentially expressed genes associated with asthma in children based on the bioanalysis of the regulatory network Chunyan Wang, Hengtao Li, Lanfang Cao, Genzai Wang View Abstract ❯
Identification of a noncoding RNA‑mediated gene pair‑based regulatory module in Alzheimer's disease Lin Yu, Shi Qian, Sun Wei View Abstract ❯
Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide‑induced intestinal injury Ying Xiong, Kai‑Xue Li, Hong Wei, Lu Jiao, Shao‑Yong Yu, Li Zeng View Abstract ❯
Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer Yu Jiang, Gang Liu, Li Zhang, Sheng Cheng, Chun Luo, Yang Liao, Shuliang Guo View Abstract ❯
Next‑generation sequencing‑based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, Her‑2 and TP53 mutations in patients with non‑small cell lung cancer Changwen Jing, Xuhua Mao, Zhuo Wang, Kejing Sun, Rong Ma, Jianzhong Wu, Haixia Cao View Abstract ❯
Recombinant club cell protein 16 (CC16) ameliorates cigarette smoke‑induced lung inflammation in a murine disease model of COPD Min Pang, Hong‑Yan Liu, Ting Li, Dan Wang, Xiao‑Yun Hu, Xin‑Ri Zhang, Bao‑Feng Yu, Rui Guo, Hai‑Long Wang View Abstract ❯
Inhibitory effects of TGP on KGF‑induced hyperproliferation of HaCaT cells via suppression of the p38 MAPK/NF‑κB p65 pathway Weirong Pang, Xiaoming Qi, Chunmei Cao, Shuosheng Zhang View Abstract ❯
PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways Eun Ji Ryu, Dae Won Kim, Min Jea Shin, Hyo Sang Jo, Jung Hwan Park, Su Bin Cho, Chi Hern Lee, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Duk‑Soo Kim, Sung‑Woo Cho, Yong‑Jun Cho, Eun Jeong Sohn, Ora Son, Keun Wook Lee, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Choi View Abstract ❯
miR‑214 mediates vascular inflammation and apoptosis via PTEN expression Mingliang Wang, Min Liu, Ting Ni, Qiliang Liu View Abstract ❯
Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway Hong‑Yu Meng, De‑Cheng Shao, Han Li, Xiao‑Dan Huang, Guang Yang, Bing Xu, Hai‑Yun Niu View Abstract ❯
Identification of open chromosomal regions and key genes in prostate cancer via integrated analysis of DNase‑seq and RNA‑seq data Xin Wei, Lili Yu, Xuefei Jin, Lide Song, Yanting Lv, Yuping Han View Abstract ❯
BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy Xun Wang, Shuai Wang, Yuan Zhou, Halmurat Obulkasim, Zhi‑Heng Zhang, Bo Dai, Wei Zhu, Xiao‑Lei Shi View Abstract ❯
Aclidinium bromide inhibits the growth and metastasis of gastric cancer MKN‑28 cells via the PI3K signaling pathway Yuanzhi Wang, Ping Cui, Jingjing Liu, Hongxia Wu, Jun Ma View Abstract ❯
LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR‑4310/LGR5/Wnt/β‑catenin signaling pathway Niancai Jing, Tao Huang, Huaiyu Guo, Jili Yang, Mingjing Li, Zhuo Chen, Yue Zhang View Abstract ❯
Pyroptosis, a novel mechanism implicated in cataracts Xin Jin, Hao Jin, Yan Shi, Yiyuan Guo, Hong Zhang View Abstract ❯
MicroRNA‑326 inhibits endometrial fibrosis by regulating TGF‑β1/Smad3 pathway in intrauterine adhesions Jing Ning, Hongtao Zhang, Hongwei Yang View Abstract ❯
Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression Hai‑Yan Wei, Rui Feng, Hua Shao, Bin Feng, Hong‑Qiang Liu, Jin‑Long Men, Wei Zou View Abstract ❯
Captopril inhibits calpain‑mediated apoptosis of myocardial cells in diabetic rats and improves cardiac function Li‑Ya Dong, Li‑Ping Yao, Jing Zhao, Ke‑Ke Jin, Xiao‑Xiao Qiu View Abstract ❯
The close association between IL‑12Rβ2 and p38MAPK, and higher expression in the early stages of NSCLC, indicates a good prognosis for survival Zhaoguo Liu, Weilin Yang, Shibin Yang, Kaican Cai View Abstract ❯
Thymosin β4 promotes endothelial progenitor cell angiogenesis via a vascular endothelial growth factor‑dependent mechanism Yanbo Zhao, Jiale Song, Xukun Bi, Jing Gao, Zhida Shen, Junhui Zhu, Guosheng Fu View Abstract ❯
CNOT1 is involved in TTP‑mediated ICAM‑1 and IL‑8 mRNA decay Jia‑Xin Shi, Jia‑Shu Li, Rong Hu, Xin‑Cheng Zhao, Cheng‑Cheng Liang, Xiao‑Min Li, Hong Wang, Yi Shi, Xin Su View Abstract ❯
miR‑590‑5p suppresses osteosarcoma cell proliferation and invasion via targeting KLF5 Wei Cai, Yong Xu, Jian Yin, Wenshan Zuo, Zhen Su View Abstract ❯
Intraperitoneal oxaliplatin administration inhibits the tumor immunosuppressive microenvironment in an abdominal implantation model of colon cancer Hong‑Feng Gou, Lei Zhou, Jia Huang, Xin‑Chuan Chen View Abstract ❯
The effects of hyperoxia liquid regulate cardiopulmonary bypass‑induced myocardial damage through the Nrf2‑ARE signaling pathway Xiaochun Ma, Bin Hu, Chengwei Zou, Aiguo Han, Zhenqiang Xu, Tao Zhang, Wancheng Yu View Abstract ❯
Protective properties of spliced X box binding protein 1 in ozone‑induced spinal cord neuronal death Yun Li, Xu Zhao, Xiaowen Lin, Xuejun Zhao, Juntian Xie, Tao Sun, Zhijian Fu View Abstract ❯
JAG1 loss‑of‑function mutations contributed to Alagille syndrome in two Chinese families Erge Zhang, Yuejuan Xu, Yongguo Yu, Sun Chen, Yu Yu, Kun Sun View Abstract ❯
Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation Qiang Liu, Qingshan Wang, Haibin Li View Abstract ❯
MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation Yan Jin, Qiuyun Tu, Min Liu View Abstract ❯
Polymorphism rs7521584 in miR‑429 is associated with the severity of atrophic gastritis in patients with Helicobacter pylori infection Toshimi Otsuka, Tomomitsu Tahara, Masakatsu Nakamura, Wu Jing, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Tomoyuki Shibata, Tomiyasu Arisawa View Abstract ❯
Montelukast inhibits RANKL‑induced osteoclast formation and bone loss via CysLTR1 and P2Y12 Ju‑Hee Kang, Hyungsik Lim, Dong‑Seok Lee, Mijung Yim View Abstract ❯
Urinary C‑X‑C motif chemokine 13 is a noninvasive biomarker of antibody‑mediated renal allograft rejection Dajin Chen, Jian Zhang, Wenhan Peng, Chunhua Weng, Jianghua Chen View Abstract ❯
MicroRNA‑485 targets MACC1 and inhibits cervical cancer cell proliferation and invasion Shumei Wang, Yaqi Zhang, Shunping Yuan, Xiaoling Ji View Abstract ❯
Association study of frameshift and splice variant polymorphisms with risk of idiopathic recurrent pregnancy loss Hyun Ah Lee, Eun Hee Ahn, Ji Hyang Kim, Jung Oh Kim, Chang Soo Ryu, Jeong Yong Lee, Sung Hwan Cho, Woo Sik Lee, Nam Keun Kim View Abstract ❯
Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice Hu‑Nan Sun, Li Feng, Ai‑Guo Wang, Jing‑Yu Wang, Lei Liu, Mei‑Hua Jin, Gui‑Nan Shen, Cheng‑Hao Jin, Dong‑Soek Lee, Tae‑Ho Kwon, Yu‑Dong Cui, Dae‑Yeul Yu, Ying‑Hao Han View Abstract ❯
Downregulation of microRNA‑660 inhibits cell proliferation and invasion in osteosarcoma by directly targeting forkhead box O1 Peng Zhang, Haifeng Gao, Qing Li, Xinlei Chen, Xifa Wu View Abstract ❯
Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family Qasem Abdallah, Ibrahim Al‑Deeb, Ammar Bader, Fayez Hamam, Kamel Saleh, Amin Abdulmajid View Abstract ❯
Liraglutide improves cognitive impairment via the AMPK and PI3K/Akt signaling pathways in type 2 diabetic rats Ying Yang, Hui Fang, Gang Xu, Yanfeng Zhen, Yazhong Zhang, Jinli Tian, Dandan Zhang, Guyue Zhang, Jing Xu View Abstract ❯
HAUS8 regulates RLR‑VISA antiviral signaling positively by targeting VISA Tian‑Sheng He, Tian Chen, Dan‑Dan Wang, Liang‑Guo Xu View Abstract ❯
The NRF2‑PGC‑1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, synoviolin, in a cecal ligation/perforation‑induced septic mouse model Yusuke Ishida, Hidetoshi Fujita, Satoko Aratani, Miyuki Chijiiwa, Noboru Taniguchi, Maho Yokota, Yukihiko Ogihara, Naomi Uoshima, Fumiaki Nagashima, Hiroyuki Uchino, Toshihiro Nakajima View Abstract ❯
Methylation profiles of miR34 gene family in Vietnamese patients suffering from breast and lung cancers Vo Thi Thuong Lan, Ho Van Son, Vu Lan Trang, Nguyen Thu Trang, Nguyen Thi Phuong, Nguyen Linh Toan, Pham Anh Thuy Duong View Abstract ❯
Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis Sirikul Kulanuwat, Prapaporn Jungtrakoon, Watip Tangjittipokin, Pa‑Thai Yenchitsomanus, Nattachet Plengvidhya View Abstract ❯
miR‑30a‑5p inhibits the proliferation, migration and invasion of melanoma cells by targeting SOX4 Erbiao Liu, Xiyan Sun, Jinping Li, Chao Zhang View Abstract ❯
Assessment of the effects of prostaglandins on myometrial and leiomyoma cells in vitro through microRNA profiling Hwi Gon Kim, Ga Young Jung, Seung Bin Park, Yeon Jean Cho, Myoungseok Han View Abstract ❯
Effects of constrained dynamic loading, CKIP‑1 gene knockout and combination stimulations on bone loss caused by mechanical unloading Biao Han, Shu‑Ping Wei, Xin‑Chang Zhang, Hao Li, Yu Li, Rui‑Xin Li, Kairen Li, Xi‑Zheng Zhang View Abstract ❯
[Corrigendum] Differences in atrial fibrillation‑associated proteins between the left and right atrial appendages from patients with rheumatic mitral valve disease: A comparative proteomic analysis Hai Liu, Guangxian Chen, Hongsheng Zheng, Han Qin, Mengya Liang, Kangni Feng, Zhongkai Wu View Abstract ❯

20-22 September, 2018, Metropolitan Hotel, Athens, Greece 23nd World Congress on Advances in Oncology & 22th International Symposium on Molecular Medicine 18-19 September 2018, Pre-Congress Workshop: 'MicroRNA Analysis'

28-30 March, 2019, Tawana Hotel, Bangkok, Thailand 23 rd International Symposium on Molecular Medicine

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A new concept for risk analysis relating to the degradation of water reservoirs

Abstract

This paper presents a proposal for a procedure by which to analyse the risk of reservoirs being degraded. The body of water assessed for its susceptibility to degradation in line with the proposed procedure is Myczkowce Reservoir, SE Poland. This reservoir has a maximum capacity of ten million m³ and helps provide hydropower, by serving as a surge tank located above the main Solina Reservoir. On the basis of an assessment of its morphometric and hydrological parameters, Myczkowce Reservoir was assigned to the low-resilience category where risk of degradation was concerned. The primary factors responsible for that are limited capacity in relation to shoreline length, a lack of thermal stratification, and a high value for the Schindler index. These and other environmental parameters provided for Myczkowce's assignment to the category of susceptible to the impact of matter supplied by its catchment, with this reflecting the instantaneous nature of the basin, high values for the Ohle coefficient, average catchment slope, and the lack of a septic system. The designated risk level supported Myczkowce's assignment to a category characterised by an "unacceptable" risk of degradation. The proposed method taking two parameters (resilience and susceptibility) into account represents the first universal method for assessing reservoirs without reference to risks such as drought, flooding, or lack of water supply for human consumption. The risk depends only on the reservoir and catchment parameters.

https://ift.tt/2KyzSIL

Case Report of Syncope during a Transcranial Direct Current Stimulation Experiment in a Healthy Adult Participant

Publication date: Available online 28 June 2018
Source:Brain Stimulation
Author(s): Flora Li, Sheryl Ball, Benjamin Katz, Alec Smith




https://ift.tt/2yVdyHO

Diazoxide toxicity in a child with persistent hyperinsulinemic hypoglycemia of infancy: mixed hyperglycemic hyperosmolar coma and ketoacidosis

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2lFlovQ

Reactive uptake of ammonia by secondary organic aerosols: Implications for air quality

Publication date: September 2018
Source:Atmospheric Environment, Volume 189
Author(s): Jeremy R. Horne, Shupeng Zhu, Julia Montoya-Aguilera, Mallory L. Hinks, Lisa M. Wingen, Sergey A. Nizkorodov, Donald Dabdub
Reactions between ammonia (NH3) and organic compounds containing carbonyl functional groups in aerosol particles can form organic products that are less basic than NH3 and are thus unable to neutralize efficiently nitric and sulfuric acids. In this exploratory study, the University of California, Irvine - California Institute of Technology (UCI-CIT) model is used to investigate the potential air quality impacts of including of the chemical uptake of NH3 by secondary organic aerosols (SOA) in a regional airshed model. A surface reaction of NH3 with SOA is implemented into the model to determine the impact of this process on NH3 and PM2.5 concentrations in the South Coast Air Basin of California (SoCAB). Air quality simulations are conducted using uptake coefficients ranging from 10⁻⁵ to 10⁻² to explore the sensitivity of changes in NH3 and PM2.5 concentrations to the magnitude of the uptake coefficient. Results indicate that the chemical uptake of NH3 by SOA can potentially deplete gaseous NH3 concentrations, causing indirect reductions in the amount of ammonium nitrate and ammonium sulfate in particulate matter. The magnitude of the impact on NH3 and PM2.5 concentrations exhibits a strong but non-linear dependence on the value of the uptake coefficient, with evidence for small but notable impacts on air quality even with the lowest assumed uptake coefficient of 10⁻⁵.



https://ift.tt/2Kvvg9y

Ilex paraguariensis Extends Lifespan and Increases an Ability to Resist Environmental Stresses in Drosophila

Rejuvenation Research, Ahead of Print.


https://ift.tt/2KhlUi8

Stop eating plastic, molecular signaling of bisphenol A in breast cancer

Abstract

Breast cancer is the second most common fatal cancer in women. Developing a breast cancer is a multi-factorial and hormonal-dependent process, which may be triggered by many risk factors. An endocrine disrupting substance known as bisphenol A (BPA), that is used greatly in the manufacture of plastic products, was suggested as a possible risk factor for developing breast cancer. BPA has a strong binding affinity to non-classical membrane estrogen receptors like estrogen-related and G protein-coupled (GPER) receptors. Based on animal and in vitro studies, results showed a link between BPA exposure and increased incidence of breast cancer. BPA has the ability to alter multiple molecular pathways in cells namely, G protein-coupled receptor (GPER) pathway, estrogen-related receptor gamma (ERRγ) pathway, HOXB9 (homeobox-containing gene) pathway, bone morphogenetic protein 2 (BMP2) and (BMP4), immunoregulatory cytokine disturbance in the mammary gland, EGFR-STAT3 pathway, FOXA1 in ER-breast cancer cells, enhancer of zeste homolog 2 (EZH2), and epigenetic changes. Thus, the aforementioned alterations cause undesired gene stimulation or repression that increase risk of developing breast cancer. So, restricting exposure to BPA should be considered to aid in lowering the risk of developing breast cancer.

https://ift.tt/2ICZxy0

Removal of aromatic and hydrophobic fractions of natural organic matter (NOM) using surfactant modified magnetic nanoadsorbents (MNPs)

Abstract

The present study investigated the potential of surfactant modified magnetic nanoadsorbents (MNPs) for the removal of aromatic and hydrophobic fractions of natural organic matter (NOM), leading to the formation of trihalomethanes (THMs) in chlorinated drinking water. Co-precipitation method was used for the synthesis of MNPs. However, MNPs have a tendency to form an agglomeration. Therefore, polyethylene glycol (PEG) was used as a surface modifier to reduce the agglomeration. The PEG-coated MNPs were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray analysis (EDX), BET surface area, X-ray diffraction (XRD), Fourier transform spectrometer (FTIR), and zeta (ζ) potential. FESEM observation indicates that PEG-coated MNPs were spherical in shape and 25 nm in size. Zeta potential values (− 58.35 to − 74.9 mV) indicated excellent stability of PEG-MNPs. FTIR spectra indicated the presence of a −CH₂ group, responsible for the chemical interaction between aromatic and humic content. Batch experiments were conducted by studying the effect of pH, contact time, and adsorbent dosage on NOM removal. Excellent removal of DOC (94.49%) and UV₂₅₄ (89.32%) was observed at the optimum dose of adsorbent (0.75 g/L) and at pH 7.0. Adsorption kinetics followed pseudo-second-order reaction (R², 0.973) and occurs by multilayer chemisorption which is due to the chemical interaction between aromatic and humic compounds of NOM with MNPs. Thus, MNPs showed great potential as a novel adsorbent for the removal of aromatic and hydrophobic compounds of NOM and can significantly be used to curtail the problem of THMs in drinking water supplies.

https://ift.tt/2Kkqexd

Effect of controlled-release fertilizer on N 2 O emissions and tea yield from a tea field in subtropical central China

Abstract

Tea (Camellia sinensis L.), a perennial leaf-harvested crop, favors warm/humid climate and acidic/well-drained soils, and demands high nitrogen (N) fertilizer inputs which lead to significant emissions of N₂O. Potential mitigation options should be adopted to improve N use efficiency (NUE) and reduce environmental pollution in tea field system. A 3-year field experiment was carried out in a tea field in southern China from January 2014 to December 2016 to investigate the effect of controlled-release fertilizer (CRF) application on N₂O emissions in tea field system. Three practices, namely conventional treatment (CON, 105 kg N-oilcake ha⁻¹ year⁻¹ + 345 kg N-urea ha⁻¹ year⁻¹), treatment with a half amount of the N fertilizer (CRF50%, 105 kg N-oilcake ha⁻¹ year⁻¹ + 120 kg N CRF ha⁻¹ year⁻¹) and full amount of N fertilizer (CRF100%, 105 kg N-oilcake ha⁻¹ year⁻¹ + 345 kg N CRF ha⁻¹ year⁻¹) were used. Compared with the CON, our results showed that CRF50% reduced the N₂O emissions by 26.2% (p > 0.05) and increased the tea yield by 31.3% (p > 0.05), while CRF100% significantly increased the N₂O emissions by 96.7% (p < 0.05) and decreased the tea yield by 6.77% (p > 0.05). Overall, yield-scaled N₂O emissions of tea were reduced by 44.5% (p > 0.05) under CRF50% and significantly increased by 100% (p < 0.05) under CRF100%, compared with CON. Based on the gross margin analysis, CRF50% obtained the highest net economic profit. Our findings suggest that reducing N input of CRF (CRF50%) is necessary and feasible for adoption in the current tea plantation system.

https://ift.tt/2IHdA5W

Corrigendum: Chronic Inflammatory Pain Impairs mGluR5-Mediated Depolarization-Induced Suppression of Excitation in the Anterior Cingulate Cortex

https://ift.tt/2KigCmO

Understand the resilience and regime shift of the wetland ecosystem after human disturbances

Publication date: 1 December 2018
Source:Science of The Total Environment, Volume 643
Author(s): Hanxiang Liu, Chuanyu Gao, Guoping Wang
Wetland protection and restoration are important for human's sustainable development, and assess the resilience and regime shift of wetland ecosystem under human disturbances is necessary for this purpose. Geochemical records, including nitrogen (N), phosphorus (P), heavy metals and polycyclic aromatic hydrocarbons (PAHs) from seven wetland cores dated by ²¹⁰Pb and ¹³⁷Cs analysis were used to identify the historical background of human disturbances on wetlands in the Sanjiang Plain. We also carried out paleoecological analysis (including plant macrofossils and diatoms) in one core (Honghe wetland) to reconstruct the successions of wetland ecological communities. The resilience and regime shift of ecosystem were evaluated based on autocorrelation and the Sequential t-test analysis of regime-shifts algorithm. Our results show that enrichment factors (EFs) of N, P and heavy metals (Cu, Zn, Pb etc.), and the concentrations of PAHs experienced slight increases from the 1920s but dramatic increases from the late 1970s. The dominant species of plant community began to change from Drepanocladus aduncus to Carex lasiocarpa from the late 1970s, and the diatoms began to change from wet-indicator to dry-indicator species from the 1950s in Honghe wetland. The regime shift of the wetland ecosystem occurred around 1990 CE, which due to a drop in water level caused by human activities, such as wetland drainage for the reclamation and the excessive use of groundwater for irrigation purpose, rather than climate moisture variations. There is a time gap between the severe disturbances and regime shift due to the stronger resilience of wetland ecosystem. The ecological characteristics (e.g. water level, biological compositions, and EFs of nutrient elements and heavy metals) of Honghe wetland before the late 1970s (release phase) were used as reference conditions for wetland restoration.

Graphical abstract

https://ift.tt/2NakGmP

Wetlands for wastewater treatment and subsequent recycling of treated effluent: a review

Abstract

Due to water scarcity challenges around the world, it is essential to think about non-conventional water resources to address the increased demand in clean freshwater. Environmental and public health problems may result from insufficient provision of sanitation and wastewater disposal facilities. Because of this, wastewater treatment and recycling methods will be vital to provide sufficient freshwater in the coming decades, since water resources are limited and more than 70% of water are consumed for irrigation purposes. Therefore, the application of treated wastewater for agricultural irrigation has much potential, especially when incorporating the reuse of nutrients like nitrogen and phosphorous, which are essential for plant production. Among the current treatment technologies applied in urban wastewater reuse for irrigation, wetlands were concluded to be the one of the most suitable ones in terms of pollutant removal and have advantages due to both low maintenance costs and required energy. Wetland behavior and efficiency concerning wastewater treatment is mainly linked to macrophyte composition, substrate, hydrology, surface loading rate, influent feeding mode, microorganism availability, and temperature. Constructed wetlands are very effective in removing organics and suspended solids, whereas the removal of nitrogen is relatively low, but could be improved by using a combination of various types of constructed wetlands meeting the irrigation reuse standards. The removal of phosphorus is usually low, unless special media with high sorption capacity are used. Pathogen removal from wetland effluent to meet irrigation reuse standards is a challenge unless supplementary lagoons or hybrid wetland systems are used.

https://ift.tt/2IBWHJu

Numéro 6/2018. Questions

Publication date: Available online 29 June 2018
Source:Revue des Maladies Respiratoires





https://ift.tt/2Kzrb0C

Analysis of the adsorption and retention models for Cd, Cr, Cu, Ni, Pb, and Zn through neural networks: selection of variables and competitive model

Abstract

In this study, the neural networks are used to predict and explain the behavior of different edaphological variables in the adsorption and retention of heavy metals, both isolated and competing. A comparison with the results obtained using multiple regression, stepwise analysis, and regression trees is performed. In the neural network technique, CEC amorphous and crystallized oxides and kaolinite in the clay fraction are the most selected variables for making the optimal models, while mica and, to a lesser extent, plagioclase, are the next variables selected. Additionally, a competitive model has been considered, using simultaneously different metals. In the competitive model, the model predicts a more intense competence between Pb and Ni for the adsorption process and between Cr and Ni for the retention process.

https://ift.tt/2IDq52e

Delayed post-curing stage and oxygen inhibition of free-radical polymerization of dimethacrylate resin

Publication date: Available online 29 June 2018
Source:Dental Materials
Author(s): Mikke K. Aromaa, Pekka K. Vallittu
ObjectiveIt is known that after light-initiated free radical polymerization of a dimethacrylate monomer system, the curing continues for some period of time after the curing light emission has stopped (so-called delayed post-curing stage, DPCS). It is also known that during free radical polymerization, the presence of oxygen effectively inhibits polymerization of monomers. However, less is known of the influence of oxygen inhibition of light initiated polymerization during the DPCS. The aim of this study was to determine some polymerization related properties of a resin system during the DPCS.MethodsMonomer systems of BisGMA-TEGDMA (60/40%) with light sensitive initiator-activator (camphorquinone-amine) system were polymerized by light-initiation (wavelength average 430–480nm) with a radiation intensity of 1200mW/mm² for 20s on the ATR sensor of the fourier transform infrared (FTIR) spectrometer. After light curing, the samples were divided into two groups: the DPCS stage was allowed to continue in air (O2-exposed group) or the samples were protected from the direct effect of air (O2-protected group). The degree of monomer conversion (DC%) was monitored from the sample surface up to 360min from both groups of samples (n=6). Sample surfaces were additionally analyzed for surface microhardness (VHN) at four time-points corresponding to time-points of the DC% measurement (n=6).ResultsAfter ending the light-curing of 20s, i.e. during the DPCS, the DC% still increased from 50% to 65% in the O2-protected group, whereas no increase was seen in the O2-exposed group. Surface microhardness increased from 2.99 to 9.10 VHN of the O2-protected samples and to 4.80 of the O2-exposed samples during a 6-h period. Surface microhardness differed significantly between the groups (p<0.005). There was significant correlation between the microhardness and DPCS (O2-protected r=0.950; O2-exposed r=0.940, p<0.001). A correlation was also found between degree of conversion values and DPCS time (O2-protected r=0.941; for O2-exposed r=0.780, p<0.001).SignificanceThe results of this study suggested that O2-inhibition of free radical polymerization of dimethacrylate resin occurred after ending the curing light emission. This correlated with a lower surface microhardness of the polymer when the DPCS continued under air-exposure.



https://ift.tt/2KhLbc5

Optimal Sequence of Adjuvant Endocrine and Radiation Therapy in Early-Stage Breast Cancer – A Systematic Review

Publication date: Available online 28 June 2018
Source:Cancer Treatment Reviews
Author(s): S.F. McGee, S. Mazzarello, J.M. Caudrelier, M.A.G. Lima, B. Hutton, M. Sienkiewicz, C. Stober, R. Fernandes, M.F.K. Ibrahim, L. Vandermeer, J. Hilton, R. Shorr, D. Fergusson, M. Clemons
Importance:Clinical equipoise exists around the optimal time to start adjuvant endocrine therapy in patients who will receive post-operative radiotherapy for breast cancer. Concerns continue to exist regarding potential reduced efficacy, or increased toxicity, when radiation, and endocrine therapy are administered concurrently.Objective:To perform a systematic review of studies comparing outcomes between sequential and concurrent adjuvant radiation and endocrine therapy in early-stage breast cancer. All modalities of radiation therapy were considered, and endocrine therapy could be either tamoxifen or an aromatase inhibitor. Outcomes of interest included; local, regional or distant recurrence, overall survival and treatment-related toxicities.Evidence Reviewed:PubMed, Ovid Medline, EMBASE, and the Cochrane Central Register of Controlled Trials were searched from 1946 to December 2017. Two reviewers independently assessed each citation using the criteria outlined above. Study quality was assessed using the Cochrane Collaboration's tool for prospective studies, and the Newcastle-Ottawa scale for retrospective studies.Findings:Of 2137 unique citations identified, 13 met eligibility criteria. Eleven were unique studies (7569 patients), while 2 of the studies were updated analyses of previous studies. Studies evaluated the timing of adjuvant radiation, and tamoxifen (5 studies, 1550 patients), or aromatase inhibitors (6 studies, 6019 patients). We identified 1 complete randomized clinical trial (150 patients), and 5 retrospective studies (1580 patients), in addition to conference abstracts (5 studies, 5839 patients). Overall, none of the studies showed a significant difference in efficacy, or toxicity, with concurrent versus sequential treatment. However, given the significant heterogeneity of the study populations, it was not possible to conduct a meta-analysis.Conclusions and Relevance:In the absence of high quality data, adequately powered randomized trials are required to answer this important clinical question.



https://ift.tt/2lHOJWv

Overview of the LUX-Lung Clinical Trial Program of Afatinib for Non–Small Cell Lung Cancer

Publication date: Available online 28 June 2018
Source:Cancer Treatment Reviews
Author(s): Namita Sharma, Stephen Graziano
Tyrosine kinase inhibitors (TKIs) have emerged as first-line treatment for the management of epidermal growth factor receptor (EGFR)–mutated advanced non–small cell lung cancer (NSCLC). Erlotinib and gefitinib were the initial TKIs to be approved for lung cancer and showed improved response rates compared with chemotherapy. Afatinib is an irreversible ErbB family blocker that has also been shown to be active in EGFR-mutated NSCLC. Afatinib has been tested as first-line treatment of advanced NSCLC in the LUX-Lung trial program, as well as in the second- and third-line settings. In this article, we will review the data from the 8 reported LUX-Lung trials.



https://ift.tt/2yQT5Ec

Potential of traditionally consumed medicinal herbs, spices, and food plants to inhibit key digestive enzymes geared towards diabetes mellitus management — A systematic review

Publication date: Available online 29 June 2018
Source:South African Journal of Botany
Author(s): A.D. Seetaloo, M.Z. Aumeeruddy, R.R. Rengasamy Kannan, M.F. Mahomoodally
Diabetes mellitus is a notorious endocrine disorder with a high global prevalence. Currently available drugs to manage such noncommunicable disease and related complications are associated with various adverse effects and discomforts. It has been argued that the use of herbs and spices can inhibit key carbohydrate and lipid digestive enzymes (amylase, glucosidase, and lipase), thereby regulating blood glucose levels and postprandial peaks in diabetics. Indeed, before the expansion of conventional medicine, dietary measures and food plants were the mainstay therapies to manage panoply of diseases, including diabetes. Nonetheless, there is still a dearth of comprehensive compilation of the potential of traditionally used herbs and spices to inhibit key digestive enzymes. This study aimed to bring to the limelight of the scientific community a comprehensive updated systematic review of the potential of traditionally used herbs, spices, and food plants which have been used traditionally against diabetes. Using the PRISMA methodology, a comprehensive and structured literature search was conducted in key databases (Pubmed, ScienceDirect, and Google Scholar). Published literature was scrutinised using specific keywords and only those published from 2008 to 2017 were included in this review. A total of 94 plants were identified as having digestive enzyme inhibitory properties; five of them against all three enzymes, 41 for both amylase and glucosidase, and one against both amylase and lipase. Different families of plants, plant parts, and type of extracts have been found to exhibit different strengths of enzyme inhibitory activities. Several research gaps have been identified that warrants due attention in future studies. It is anticipated that this study will open new avenues for research and advocates the need to probe traditional and indigenous herbs and food plants in the management of diabetes.



https://ift.tt/2tR0tcL