Scholar : ΜΕΝΙΕΡΕ - νέα αποτελέσματα

Recent and Frequent Vertigo Attacks Produce Negative Findings on Furosemide-loading Vestibular Evoked Myogenic Potential Testing in Meniere's Disease

T Seo, K Shiraishi, T Kobayashi, T Fujita, K Saito - Frontiers in Neurology, 2018

Objective: The peak-to-peak amplitude of the p13-n23 wave in cervical vestibular
evoked myogenic potential can increase after furosemide administration in patients
with Meniere's disease (furosemide-loading VEMP [FVEMP] testing). The …

The Role of Hyperbaric Oxygen as Salvage Therapy for Sudden Sensorineural Hearing Loss

G Almosnino, JR Holm, SR Schwartz, DM Zeitler - Annals of Otology, Rhinology & …, 2018

Objective: We sought to evaluate hearing outcomes after salvage therapy with hyperbaric
oxygen (HBO2) for the treatment of sudden sensorineural hearing loss (SS...

[HTML] A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss

GH Yu, YJ Choi, HJ Jung, YS Lim, SW Park, CG Cho… - Brazilian Journal of …, 2018

… Patients who were treated with either a combined intratympanic steroid
therapy or a different treatment regimen, patients with combined chronic
otitis media, those who were finally diagnosed as having either Meniere's …

Reproducibility of Volumetric Assessment of the Inner Ear Using Three Dimensional Reconstruction of the High Resolution MR Sequence

NNN Naguib, AM Emam, T Gruber-Rouh, M Harth… - Current Medical Imaging …, 2018

… The indication for MRI was hear- ing loss (n = 15), suspected vestibular schwanoma
(n = 9), tinnitus (n = 8), vertigo (n = 8), suspected Meniere's disease (n = 4), to exclude
inner ear anomalies (n = 3) and cCho- lesteatoma (n = 3). 2.2 …

Long-term effects of vestibular rehabilitation and head-mounted gaming task procedure in unilateral vestibular hypofunction: a 12-month follow-up of a randomized …

A Viziano, A Micarelli, I Augimeri, D Micarelli… - Clinical Rehabilitation, 2018

Objective: To investigate the long-term effects of adding virtual reality–based home
exercises to vestibular rehabilitation in people with unilateral vestibular...

Surgical Neuromodulation of Tinnitus: A Review of Current Therapies and Future Applications

R Rammo, R Ali, A Pabaney, M Seidman, J Schwalb - Neuromodulation: Technology at the …

… has a prevalence of 10–15% in the adult population 1. Severe tinnitus can
lead to depression in about 50% of patients and a profound deterioration
in the quality of life in 20% 2. Tinnitus is generally associated with hearing …

METHODS AND COMPOSITIONS RELATING TO ANTI-NUCLEOLIN RECOMBINANT IMMUNOAGENTS

C De Lorenzo, D Palmieri, C Croce - US Patent App. 15/741,729, 2018

… Graves' disease, Guillain-Barre, Hashimoto's thyroiditis, Henoch-Schonlein
purpura, idiopathic pulmonary fibrosis, idiopathic/autoimmune
thrombocytopenia purpura (ITP), IgA neuropathy, juvenile arthritis, lichen …

[PDF] Der Einfluss von Stress auf das Erleben von M.-Menière-Symptomen–Kommentar zu der Untersuchung von Yeo et al., 2017

H Schaaf

… Ein psychoso- matisch orientierter Leitfaden. 8. Aufl. Springer, Heidelberg 7. Schaaf H,
Beyrau D (2017): Der Einfluss von Stress bei M.-Meniere-Patienten. forum HNO (19),
175–185 8. Schaaf H, Haid CT (2003): Reaktiver psycho- gener Schwindel bei M. Menière …

EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS

J Bolen, DK Bonner, LV Ferreira, K Krumova, J Jantz… - US Patent App. 15/826,033, 2018

The present invention provides exosomes as drug delivery vehicles,
compositions comprising a therapeutic agent encapsulated within such
exosomes, methods of producing such exosomes and compositions th.

Patient-and family-centered care interventions for improving the quality of health care: a review of systematic reviews

M Park, M Lee, H Jeong, M Jeong, Y Go - International Journal of Nursing Studies

Page 1. Accepted Manuscript Title: Patient- and family-centered care interventions for
improving the quality of health care: a review of systematic reviews Authors: Myonghwa
Park, Thi-Thanh-Tinh Giap, Mihyun Lee, Hyun Jeong, Miri Jeong, Younghye Go …

 

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Ακύρωση ειδοποίησης

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Scholar : ΓΝΑΘΟΣ - νέα αποτελέσματα

[PDF] Δυσπραξία με συννοσηρότητα Διαταραχή Ελλειμματικής Προσοχής και Υπερκινητικότητα

Ό Κασάπη, Μ Μιχάλη - 2018

Page 1. ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ ΕΠΙΒΛΕΠΟΥΣΑ ΚΑΘΗΓΗΤΡΙΑ: ΙΓΝΑΤΙΟΥ ΜΑΡΙΑ ΕΚΠΟΝΗΣΗ:
ΚΑΣΑΠΗ ΟΛΓΑ 16249 ΜΙΧΑΛΗ ΜΑΡΙΑ 16217 ΘΕΜΑ: ΔΥΣΠΡΑΞΙΑ ΜΕ ΣΥΝΝΟΣΗΡΟΤΗΤΑ
ΔΙΑΤΑΡΑΧΗ ΕΛΛΕΙΜΜΑΤΙΚΗΣ ΠΡΟΣΟΧΗΣ - ΥΠΕΡΚΙΝΗΤΙΚΟΤΗΤΑΣ …

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Did carbon dioxide emission regulations inhibit investments? A provincial panel analysis of China

Abstract

Investments, especially fixed asset investments, greatly affect carbon dioxide (CO₂) emissions. When investments are concentrated in regions with high CO₂ emissions and high fossil energy consumption, the CO₂ emission reduction targets in these areas are difficult to reach in the short term, and the cost of CO₂ emission abatement is high. The current CO₂ emission regulations focus on existing production activities and consumption behaviors. However, whether an investment, which may affect CO₂ emissions in the long term, is effectively inhibited by CO₂ emission regulations has not been investigated in previous studies. Using panel data from 30 provinces in China between 2003 and 2012, we tested whether the amount of provincial investment was constrained or promoted by the provincial CO₂ emission regulations by creating a panel model with provincial samples. The results revealed that CO₂ emission regulations did not inhibit the growth of an investment, but they stimulated investments to varying degrees in different provinces. A relatively positive result is that provinces with stronger CO₂ emission regulations exhibited a relatively small contribution to investment promotion, while provinces with weaker CO₂ reduction policies demonstrated a relatively large contribution to investment growth. We also found that investment was correlated with the growth rate of the gross domestic product (GDP) in the northeastern and western provinces. Finally, we proposed policy implications based on the utilization of policy tools from the perspectives of investment, energy structure, and local protectionism.

https://ift.tt/2O5HeFN

Erythematous Bullous Patch in a Patient With Myelodysplastic Syndrome: Answer

No abstract available

https://ift.tt/2uFvrpv

Juvenile-Onset Early-Stage Mycosis Fungoides–Associated Follicular Mucinosis: A Case Report

Abstract: We report a juvenile case of mycosis fungoides with prominent follicular mucinosis (FM). The patient was a 9-year old boy who presented with a 2-month history of enlarging alopecic patch with fine scales on the scalp. Dermatologic examination revealed orange-tan slightly palpable plaques with follicular prominence on his trunk. The patient and his family were not aware of these asymptomatic truncal plaques. Histopathologic examination of both—scalp and trunk—lesions revealed folliculotropic lymphocytic infiltration with mucin. Immunohistochemical study showed that lymphocytic infiltration was CD4 dominant. Flow cytometry analyses of peripheral blood were normal. Any abnormal populations and Sézary cells were not observed on blood smear. Polymerase chain reaction testing showed monoclonality for the T-cell receptor4-[Latin Small Letter Rams Horn] gene. Our patient had the clinical and histopathological diagnosis of follicular mycosis fungoides–associated follicular mucinosis.

https://ift.tt/2zUwOWA

CD34 and BerEP4 Are Helpful to Distinguish Basaloid Tricholemmoma From Basal Cell Carcinoma

Abstract: Tricholemmoma, a benign follicular neoplasm with outer root sheath differentiation, typically comprises clear or pale cells, and when multiple is pathognomic of Cowden's syndrome. The tumor is probably underrecognized and in basaloid examples can be difficult to distinguish from basal cell carcinoma (BCC). We studied 55 tricholemmomas (including 15 basaloid cases) and compared immunohistochemical profile with nodular BCC from our archives. Basaloid and non–basaloid tricholemmomas had similar staining characteristics. BerEP4 was focally positive (range 10%–20%) in only 3/39 (7.7%) tricholemmomas compared with widespread positivity in BCC (90.8%, 139 of 151 cases with ≥50% tumor area stained). CD34 was expressed, usually focally (median 20%, range 10%–90%), in 52/53 (98.1%) tricholemmomas and was negative in all 21 BCCs stained. EMA staining lacked sensitivity or specificity in differentiating tricholemmoma from BCC. Five or more Merkel cells were found in 7/17 (40.1%) tricholemmomas and 1/23 (4.3%) nodular BCCs studied. In summary, immunohistochemistry is helpful in distinction between tricholemmoma, including difficult basaloid examples (BerEP4 negative or focal, CD34 positive) compared with BCC (BerEP4 widespread in most cases, CD34 negative). The presence of 5 or more Merkel cells is a relatively specific but not a particularly sensitive discriminator.

https://ift.tt/2uFvD8d

Melanocytic Nevus Does Not Metastasize!

No abstract available

https://ift.tt/2LAuQMk

Subcutaneous Panniculitis-Like T-Cell Lymphoma Versus Lupus Erythematosus Panniculitis: Distinction by Means of the Periadipocytic Cell Proliferation Index

Abstract: The distinction between subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and lupus erythematosus (LE) panniculitis is remarkably challenging. Rimming by lymphocytes with an elevated Ki-67 cell proliferation index has been forwarded as a potential diagnostic finding in biopsies of SPTCL but has not been rigorously compared with biopsies from patients with LE panniculitis. Nineteen and 17 examples of SPTCL and LE panniculitis, respectively, were evaluated for periadipocytic rimming by lymphocytes expressing Ki-67, CD8, and βF1 and for attributes associated with LE, including clusters of CD123-positive cells. The identification of periadiopocytic rimming using Ki-67, CD8, and βF1 held sensitivity of 79%, 100%, and 89.5% and specificity of 100%, 52.9%, and 88.2%, respectively (P

https://ift.tt/2uFvyRX

Cutaneous Angiosarcoma of the Eyelid Mimicking Morbihan Disease

Background: Cutaneous angiosarcoma presents clinically in numerous ways, and can be mistaken for a different clinical entity, particularly when arising at unusual anatomic locations such as the eyelid. Case Presentation: A 57-year-old woman presented with a 1-year history of eyelid swelling. Concurrent imaging was also suggestive of an edematous process. Multiple superficial biopsies showed nonspecific dermal inflammation and interstitial edema. A diagnosis of Morbihan disease (chronic and idiopathic lymphedema of the eyelid) was rendered, and the patient was treated with compression and local therapy without clinical improvement. Three years after initial presentation, a diagnostic blepharoplasty was performed revealing a deep dermal vascular proliferation composed of anastomosing vascular channels with an atypical endothelial lining. A diagnosis of cutaneous angiosarcoma was ultimately made. Conclusions: This case illustrates a unique presentation of cutaneous angiosarcoma and the implications of different biopsy techniques in acquiring the correct diagnosis.

https://ift.tt/2LBLUBx

Cutaneous Squamous Cell Carcinoma With Sclerosing Features: An Uncommon and Potentially Aggressive Variant

Abstract: Sclerosing squamous cell carcinoma (SCC), also known as "desmoplastic" SCC, is a rare subtype of cutaneous malignancy. This variant is clinically significant because it is associated with an increased risk of local recurrence and metastasis. We herein present 16 examples of sclerotic SCC of the skin in 8 men and 3 women, with a median age of 66 years. The most common site of origin for this tumor is the skin of the head and neck, including the scalp (5 tumors in 2 different patients), forehead (3 cases), nasal ala (2 cases), neck (2 cases in the same patient), ear (2 cases), cheek (1 case), and chest (1 case). Microscopically, sclerosing SCCs are characterized by cellular cords, nests, and islands, as well as scattered single cells infiltrating densely desmoplastic and collagenized connective tissue. The differential diagnosis principally includes sclerosing basal cell carcinoma, microcystic adnexal carcinoma, and desmoplastic trichoepithelioma. The main goals of this study are to further characterize these lesions pathologically, and increase general awareness of this SCC subtype.

https://ift.tt/2uDhqZD

Lymph Node Metastasis With Both Components of Combined Cutaneous Squamous Cell Carcinoma/Merkel Cell (Neuroendocrine) Carcinoma

No abstract available

https://ift.tt/2LBLPhd

Polymorphous Sweat Gland Carcinoma: An Immunohistochemical and Molecular Study

Abstract: Polymorphous sweat gland carcinoma is an uncommon low-grade malignant adnexal tumor with a marked predilection for the distal extremities. Histologically, the lesions are characterized by a cellular proliferation showing a combination of growth patterns, including trabecular, solid, tubular, cribriform, or adenoid cystic and pseudopapillary. The immunohistochemical and molecular profile of these tumors has not yet been properly addressed. We have studied 3 cases of polymorphous sweat gland carcinoma using a broad panel of immunohistochemical markers including cytokeratin AE1/AE3, CK5/6, MOC31, p40, p63, p16, chromogranin, synaptophysin, CD56, MIB-1, estrogen receptor, progesterone receptor, androgen receptor, BER-EP4, smooth muscle actin, epithelial membrane antigen, carcinoembryonic antigen, CD117, S100 protein, HBME-1, DOG1, vimentin, and mammaglobin. We also examined for the MYB-NFIB fusion by fluorescent in situ hybridization (ISH) and for human papilloma virus by ISH. Our studies show that cytokeratin AE1/AE3, CK5/6, p40, p63, p16, chromogranin, and CD56 stains were positive in all 3 cases. All 3 cases were negative for MYB-NFIB fusion by fluorescent ISH which rules out adenoid cystic carcinoma. DNA ISH studies for high-risk human papilloma virus were negative in all cases. MIB-1 proliferation index was very high (30%–70% nuclear positivity), supporting a malignant phenotype. The positivity for chromogranin and CD56 suggests partial neuroendocrine differentiation. The differential diagnosis includes metastases from internal malignancies, basal cell carcinoma, and other benign and malignant adnexal neoplasms such as adenoid cystic carcinoma, ductal eccrine carcinoma, and microcystic carcinoma. Positivity for p16 in combination with chromogranin and CD56 may be potentially good markers for differentiating this tumor from other adnexal tumors.

https://ift.tt/2uDhmJn

Erythematous Bullous Patch in a Patient With Myelodysplastic Syndrome: Challenge

No abstract available

https://ift.tt/2LAoZGI

Langerhans Cell Histiocytosis Associated With Underlying Hematolymphoid Disorders in Adults: Report of 2 Cases and Review of the Literature

Abstract: Langerhans cell histiocytosis (LCH) is an uncommon disorder characterized by proliferation of abnormal LCs usually affecting children and adolescents. LCH in adults first presenting in the skin is rare. Although LCH and even LCH with a second malignancy may be more common in children, cutaneous LCH with a second hematologic malignancy has been more commonly identified in adults. The authors report 2 new cases of LCH in adult patients with underlying myelodysplasia and follicular lymphoma. The specimens were examined by routine microscopy and immunohistochemical stains for S100 protein and CD1a. Patients were elderly men with established diagnoses of follicular lymphoma and myelodysplasia, presented with follicular lesions and erythematous plaques involving intertriginous areas. Histologic examination revealed collections of mononuclear cells in upper dermis, which demonstrated strong positivity for S100 and CD1a, confirming their identity as LCs. BRAF analysis returned negative for detection of BRAF V600E mutation in both patients. The authors have recently encountered 2 cases of adult patients with skin-limited LCH predated by other lymphoproliferative disorders. The association between LCH and hematopoietic disorders may be explained by a common bone marrow precursor that is differentiating along different cell lines. Cutaneous LCH may be associated with underlying lymphoproliferative disorders and should be considered in the differential diagnosis of cutaneous eruptions in patients with hematopoietic disorders. Clinical follow-up evaluation of patients diagnosed with LCH for peripheral blood abnormalities and lymphadenopathy or "B symptoms" may be prudent in patients not already carrying a diagnosis of an underlying hematologic disorder.

https://ift.tt/2uF0VvZ

Fibrous Papule: A Histopathologic Review

Abstract: Fibrous papule (FP) is a common benign lesion located primarily in the nose. Although its histogenesis has been marred with controversies in the past, the dermal dendrocyte is now largely accepted to be the putative cell of origin. Histopathologic diagnosis of an FP is straightforward in most cases, which shows characteristics of an angiofibroma. Several histologic variants have been described, recognition of which is important to avoid a misdiagnosis and inappropriate treatment. This review presents a historical perspective into the histogenesis, discusses the histopathologic features and potential diagnostic pitfalls of classic FP, and lists the various histologic variants and their differential diagnoses.

https://ift.tt/2zXVEok

Cholesterol Clefts in Basal Cell Carcinoma: An Under-Recognized Association

Abstract: Cholesterol clefts have rarely been described in cutaneous tumors other than lipid-rich tumors. However, they seem to be a relatively common phenomenon in basal cell carcinoma (BCC). This study was undertaken to determine the frequency of cholesterol cleft deposition in BCCs, and to identify associated histopathologic and clinical features. Twenty-eight of 249 BCC cases reviewed showed features of cholesterol cleft. Mean disease duration in those with cholesterol cleft was significantly longer than in those without cholesterol cleft (5.58 vs. 3.29 years, respectively; P = 0.013). Sex and age distributions, and average tumor longest diameter (11.6 vs. 9.41 mm) were no different for those with or without cholesterol clefts. The most common anatomical location was the nose in both those with and without cholesterol clefts. BCCs without cholesterol clefts more frequently involved the periauricular and perioral areas, and areas other than the head and neck, such as the trunk and lower extremities (P = 0.087). Histopathologic features of necrosis (26/28, 92.86%), keratinization (19/28, 67.86%), and pigment deposition (18/28, 64.29%) were found to be associated with cholesterol clefts. Cholesterol clefts were intratumorally located in 27/28 cases (96.43%), and stromally located in 2 cases (7.14%); intravascularly located cholesterol clefts were observed in no case. In conclusion, this study shows that cholesterol clefts are relatively common in BCC, and suggests that cholesterol crystal deposition could be associated with longer disease duration and microtrauma.

https://ift.tt/2uF0VMv

A Painful Firm Plaque on the Midback of a 53-Year-Old Woman: Answer

No abstract available

https://ift.tt/2zUwrLG

Pseudomyogenic Hemangioendothelioma: Case Report and Review of the Literature

Abstract: Pseudomyogenic hemangioendothelioma (PHE; epithelioid sarcoma-like hemangioendothelioma) is a rare entity, with 129 reported cases. It is a rarely metastasizing, low-grade vascular tumor that can histologically mimic epithelioid sarcoma and often presents as multiple discontinuous nodules in the extremities. PHEs characteristically and consistently show immunoreactivity for cytokeratins and endothelial markers. We present a case in the thigh of a 65-year-old-man with a 3-month history of painful lesions in the dermis and review the published literature. In our case, the lesion exhibited the characteristic histologic findings and immunoprofile of a PHE: a solid proliferation of spindled to epithelioid cells with abundant eosinophilic cytoplasm and frequent rhabdoid cells. Cytologic atypia and mitotic figures were inconspicuous. The tumor cells were immunoreactive for CD31, ERG, AE1/3, and CK7 and negative for D2-40, P53, HMB45, desmin, CD34, SMA, EMA, and S100 protein. A balanced reciprocal translation between chromosomes 7 and 19 was present; this translocation seems unique to PHE. PHE is a unique and commonly misdiagnosed entity; therefore, we review the literature to describe the characteristics of this tumor.

https://ift.tt/2uD72B3

Multiple Tumors on the Extremities: Answer

No abstract available

https://ift.tt/2LCTJqO

Small Vessel Vasculitis in Herpes Zoster—Discussion of Current Aspects of Varicella Zoster Virus Vasculopathy

Abstract: Varicella zoster virus (VZV) vasculopathy was initially described as herpes zoster ophthalmicus with contralateral hemiplegia in 1896. VZV is able to infect endothelial cells directly, leading to a thickened intima and vascular remodeling due to inflammation. Therefore, a spectrum of vasculopathies is induced, ranging from a discrete capillaritis-to-granulomatous vasculitis and obliterative angiitis. Cutaneous vasculitic changes sui generis with leukocytoclasia, cell debris, vascular damage, and endothelial swelling are very rare feature of herpetic infections in skin biopsies. We report an immunocompetent patient who presented with a rare form of cutaneous VZV infection of the upper leg characterized by vasculitic changes of the small vessels without typical herpetic epidermal features or neural involvement. Intriguingly, the vasculitis appeared prior to the characteristic vesicular rush without any pain symptoms. Because VZV can cause vasculopathic damage mainly within the central nervous system in immunocompetent and immunosuppressed patients, we recommend continuous clinical controls to recognize central symptoms that are related to VZV vasculopathy or giant cell arteriitis.

https://ift.tt/2uG1e9I

CD4 and CD30 Coexpression in a Cutaneous Manifestation of Systemic Mastocytosis—A Pitfall

No abstract available

https://ift.tt/2Lz2SQV

Moulages: Art and History of Medicine

Abstract: The aim of this article is to introduce the museum we have at the Pathology Department, School of Medicine of the National University of Rosario, Argentina. The origin dates from to 1922 when Dermatology Professor Dr. Enrique P. Fidanza bought moulages at L'Hôpital Saint-Louis in Paris for the purpose of teaching. The collection included around 100 moulages and was worth approximately 1000 dollars. These pieces were exhibited at the Dermatology Department for many years and later moved to the Pathology Department where some pieces started being repaired, whereas others have deteriorated. The collection is composed of 100 moulages done by a French craftsman by the name of Niclet and 258 made by Argentine craftsmen including Alba Ramirez and G. Rouzaut, among others. The pieces are classified according to different dermatological diseases such as: the different stages of syphilis, lupus, benign and malignant neoplasm, infectious diseases, etc.

https://ift.tt/2uCoFAU

A Painful Firm Plaque on the Midback of a 53-Year-Old Woman: Challenge

No abstract available

https://ift.tt/2zY2ZUN

Clinical and diagnostic significance of serum immunoglobulin A rheumatoid factor in primary Sjogren’s syndrome

Abstract

Objectives

The aim of this study was to investigate the diagnostic accuracy of rheumatoid factor (RF) isotype for the detection of primary Sjogren's syndrome (pSS) and evaluate the clinical and serological associations of immunoglobulin (Ig) A RF in patients with pSS.

Materials and methods

RF levels were measured in 77 and 37 patients with pSS and idiopathic sicca symptoms, respectively, using ELISA and analysed with respect to clinical and laboratory disease characteristics. Receiver operating characteristic curves were used to determine and compare the diagnostic accuracy of IgA RF with other diagnostic tests.

Results

Serum levels of IgA RF were significantly higher in patients with pSS than in those with idiopathic sicca symptoms. IgA RF showed sensitivity, specificity, positive, and negative predictive values of 83.1, 78.4, 88.9, and 69.0%, respectively, for pSS diagnosis. IgA RF was associated with xerostomia, severe sialoscintigraphic grade, low unstimulated salivary flow rate (USFR), antinuclear antibody, high IgG and IgM/G RF levels, and low C3 levels in patients with pSS. IgA RF titres had positive correlations with sialoscintigraphic grade and IgG and IgG/M RF levels and had negative correlations with USFR and C3 levels.

Conclusion

Our findings confirmed the potential of IgA RF to distinguish pSS from idiopathic sicca symptoms. The presence of IgA RF in patients with pSS was associated with significantly worse exocrine function and active serologic profile. No association between IgA RF and extra-glandular manifestations was noted.

Clinical relevance

IgA RF should be the predictive and diagnostic marker in patients with pSS.

https://ift.tt/2LsUfut

Cosmetics, Vol. 5, Pages 46: Cytoprotection of Antioxidant Biocompounds from Grape Pomace: Further Exfoliant Phytoactive Ingredients for Cosmetic Products

Cosmetics, Vol. 5, Pages 46: Cytoprotection of Antioxidant Biocompounds from Grape Pomace: Further Exfoliant Phytoactive Ingredients for Cosmetic Products

Cosmetics doi: 10.3390/cosmetics5030046

Authors: Daniela F. Maluf Melissa M. Gonçalves Rebeca W. O. D'Angelo Ana B. Girassol Ana P. Tulio Yasmine M. Pupo Paulo V. Farago

The goal of this study was to investigate the efficacy and the safety of grape pomace (Vitis labrusca L.) obtained from the winemaking process as an antioxidant raw material for cosmetic formulations. Grape pomace was dried and submitted to extraction with solvents. The extracts were filtered and freeze-dried. The extraction carried out with 75% acetone-water showed a better yield (1.9 g·g−1). High performance liquid chromatography (HPLC) analysis confirmed the presence of ellagic acid as an active biocompound in the extracts. The Total phenolic content of freeze-dried extracts reached 69.83 ± 1.02 mg for 75% acetone-water system. Antioxidant activity determined by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method revealed there was no statistical difference between the extract (EC50 6.9 ± 0.21) and butylated hydroxytoluene (BHT) (EC50 7.6 ± 0.71). Results of cytotoxicity showed that extracts from grape pomace were safe, even at the highest concentration tested (200 mg·mL−1) against the 3T3 cell line. Scanning Electron Microscopy (SEM) analysis revealed that there were no morphological cell changes of cells treated. Cytoprotection of cells towards the oxidation promoted by the peroxide solution was observed in the lowest concentration tested (0.73 mg·mL−1). Grape pomace from the winemaking process revealed a significant antioxidant activity attributed to its biocompounds. The safety and efficacy of extracts of grape pomace as raw material for cosmetic formulations was proposed through cell culture assays.

https://ift.tt/2O56agw

The impact of economic growth on CO 2 emissions in Australia: the environmental Kuznets curve and the decoupling index

Abstract

Australia is the sixth largest country in the world, celebrating its 26th consecutive year without a recession. However, the country is one of the ten largest emitters of greenhouse gases, mainly caused by energy use. As such, Australia is facing a trade-off between economic growth and reducing carbon dioxide (CO₂) emissions. This paper empirically analyses the relationship between economic growth and CO₂ emissions in Australia, based on annual data from 1965 to 2016, considering the consumption of the fossil fuels oil and coal and renewable energy. This analysis is performed using the environmental Kuznets curve (EKC) and the Decoupling Index (DI). The EKC is assessed by employing the autoregressive distributed lag model. In addition, a robustness check is provided through the vector error correction model, which allows for the employment of the Granger causality test. The results show that in Australia, there is evidence for the EKC hypothesis, and that the country is undergoing increasing relative decoupling. These results mean that economic growth causes CO₂ emissions and consequently environmental degradation. To achieve environmental targets and reduce the rate of CO₂ emissions while continuing to grow, Australia needs to implement measures and policies to cut CO₂ emissions, such as energy demand management and control, energy efficiency, reducing fossil fuel consumption, and investing in renewable energy technology.

https://ift.tt/2LtYUwm

Different pollutant removal efficiencies of artificial aquatic plants in black-odor rivers

Abstract

Black-odor rivers have become a prominent environmental problem, especially for developing countries. A laboratory experiment was conducted to determine the optimum operating parameters of artificial aquatic plants (AAP) to provide a theoretical and scientific basis for their application in black-odor rivers. The purification mechanism of operating parameters for AAP was also explored at the micro-organic and genetic levels by high-throughput sequencing. Chemical oxygen demand (COD) and ammonia nitrogen (NH₄⁺-N) were measured in systems with different AAP lengths and pH. After 24 days, the best removal efficiencies of APP for COD and NH₄⁺-N were 90.07 and 82.40% for 100 cm and 90.70 and 91.90% for pH values of 8.0–9.0, respectively. High-throughput sequencing analysis revealed that the relative abundance of Flavobacterium in the AAP was 7.80% at 50 cm, while the proportion increased to 29.30% at 100 cm. The abundance of microorganisms improved continuously with increased length, and the ratio of Acinetobacter increased obviously at pH 8.0–9.0 relative to pH 6.0–7.0. Furthermore, the AAP were used in Qihe Artificial Wetland in Shandong Province, China. The results revealed that the average removal efficiencies of AAP for COD and NH₄⁺-N were 27.75 and 14.34%, respectively, in the artificial wetland. Therefore, AAP was beneficial to the growth of bacteria and could be used in the treatment of black-odor rivers.

https://ift.tt/2uOWgqA

Inhibition of 1, 4-dioxane on the denitrification process by altering the viability and metabolic activity of Paracoccus denitrificans

Abstract

1,4-Dioxane is an emerging pollutant, which widely exists in natural environments and poses potential risks to the living organisms. However, its effect on the denitrification process is still unknown. In this study, the effects of 1,4-dioxane on the denitrification process were therefore investigated by using Paracoccus denitrificans as the model denitrifier. The obtained results showed that the exposure of 1,4-dioxane exhibited remarkable lag or inhibition on the denitrification process, especially with high dose. In the control without 1,4-dioxane exposure, Paracoccus denitrificans showed high denitrification efficiency (98.5%). However, the efficiency decreased to 78.5, 63.9, and 9.3% with 0.50, 0.75, and 1.0% (v/v) 1,4-dioxane dose, respectively. The dose-induced inhibition of denitrification by 1,4-dioxane could be partially attributed to the negative effects on proliferation and viability of functional microorganisms by conjugating and disrupting the cell membranes. Furthermore, 1,4-dioxane caused biotoxicity to the intracellular activities of denitrifiers via disturbing carbon source utilization and interfering the key enzymes responsible for glycolysis. The decrease of microbial viability and activity inevitably resulted in the decline of key enzymes (NAR, NIR, NOR, and N₂OR) closely related with denitrification process, which could be the direct reason for the decrease of denitrification performance.

https://ift.tt/2LtVbif

Real-time cardiac MRI with radial acquisition and k-space variant reduced-FOV reconstruction

Publication date: Available online 20 July 2018

Source: Magnetic Resonance Imaging

Author(s): Yu Y. Li, Shams Rashid, Yang J. Cheng, William Schapiro, Kathleen Gliganic, Ann-Marie Yamashita, John Tang, Marie Grgas, Michelle Mendez, Elizabeth Haag, Jianing Pang, Bernd Stoeckel, Christianne Leidecker, Jie J. Cao

Abstract

This work aims to demonstrate that radial acquisition with k-space variant reduced-FOV reconstruction can enable real-time cardiac MRI with an affordable computation cost. Due to non-uniform sampling, radial imaging requires k-space variant reconstruction for optimal performance. By converting radial parallel imaging reconstruction into the estimation of correlation functions with a previously-developed correlation imaging framework, Cartesian k-space may be reconstructed point-wisely based on parallel imaging relationship between every Cartesian datum and its neighboring radial samples. Furthermore, reduced-FOV correlation functions may be used to calculate a subset of Cartesian k-space data for image reconstruction within a small region of interest, making it possible to run real-time cardiac MRI with an affordable computation cost. In a stress cardiac test where the subject is imaged during biking with a heart rate of >100 bpm, this k-space variant reduced-FOV reconstruction is demonstrated in reference to several radial imaging techniques including gridding, GROG and SPIRiT. It is found that the k-space variant reconstruction outperforms gridding, GROG and SPIRiT in real-time imaging. The computation cost of reduced-FOV reconstruction is ~2 times higher than that of GROG. The presented work provides a practical solution to real-time cardiac MRI with radial acquisition and k-space variant reduced-FOV reconstruction in clinical settings.

https://ift.tt/2LefcKv

Novel decision algorithm for the diagnosis of silicone gel breast implant ruptures

Abstract

Background

The main complications of breast implantation are caused by capsular contracture and implant rupture. Although the evaluation of implant rupture is primarily driven by patient symptoms, including change in breast shape, size, or firmness, most patients with breast implant rupture do not clinically manifest significant symptoms, thereby developing a so-called silent rupture. For all these reasons, its diagnosis generally relies on imaging techniques such as mammography, ultrasound, and magnetic resonance imaging.

Methods

We conducted a retrospective non-randomized study, carried out between March 2013 and August 2017. In this study, we evaluated 30 symptomatic patients who underwent mono or bilateral prosthetic breast reconstruction, a total of 51 implants after skin-sparing mastectomy or nipple-sparing mastectomy for breast cancer and following breast implant removal or replacement due to suspicious rupture or capsule contraction.

Results

Ultrasound suspected ruptures in 32/51 (62.7%) implants, while 19/51 implants resulted intact upon ultrasound examination. The sensitivity and specificity of ultrasound were 90 and 80% respectively. Magnetic resonance imaging suspected ruptures in 30/51 (58.8%) implants, while 21/51 (41.1%) implants resulted intact. The magnetic resonance imaging sensitivity and specificity were 87 and 85%, respectively.

Conclusions

Ultrasound evaluation may be the first level exam in case of suspicious symptomatic breast implant rupture. Importantly, our results demonstrate that magnetic resonance imaging could be avoided in all those cases where an extracapsular rupture has been diagnosed using ultrasound.

Level of Evidence: Level IV, diagnostic study.

https://ift.tt/2mvPgLr

Evaluating the OGG1 rs1052133 and rs293795 polymorphisms in a sample of rural workers from Central Brazil population: a comparative approach with the 1000 Genomes Project

Abstract

Brazilian population is one of the largest consumers of pesticides in the world, especially the Central Brazil population. Thus, the aim of this study was to evaluate the frequency of genotypes, alleles, haplotypes, and the linkage disequilibrium (DL) of the OGG1 gene in rural workers from Central Brazil, comparing with the populations of the 1000 genome. Three hundred thirty healthy individuals not related and randomly selected were included in this study. We obtained genomic DNA from peripheral blood lymphocytes. The 748-bp OGG1 gene was amplified by PCR and sequenced. Of the 330 individuals, 215 (65%) were males and 115 (35%) were females. There were no differences in the distribution of the rs1052133 and rs293795 with age and sexes. Haplotypes containing only conserved T/C alleles were the most common in our population. The frequency of the mutant alleles of rs1052133 and rs293795, in our population, was 20% and 30%, respectively, and it is noteworthy, worldwide, that mutant alleles are commonly associated to an increased risk for the development of cancer, specially due to direct or indirect contact to pesticides, as occurs in rural workers of Central Brazil population.

https://ift.tt/2LbI1XS

Van Wyk-Grumbach syndrome with hemangioma in an infant

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2uR6p6e

Topical micronutrients in atopic dermatitis—An evidence‐based review

Dermatologic Therapy, EarlyView.


https://ift.tt/2NuFrJg

Highly‐focused ultrasound in non‐invasive body contouring: Long‐term follow‐up in Korean patients

Dermatologic Therapy, EarlyView.


https://ift.tt/2O6nkui

The 13th International Pan Arab League of Dermatology Conference Held Jointly with the Ninth Dermopolitan Congress Jordan at the Dead Sea, Jordan

Dermatologic Therapy, EarlyView.


https://ift.tt/2NuFm8q

Oral Isotretinoin for the treatment of Aripiprazol‐induced acneiform rash

Dermatologic Therapy, EarlyView.


https://ift.tt/2O3xBao

PDT and BF‐200 ALA: The therapy option for the treatment of Poikiloderma of Civatte

Dermatologic Therapy, EarlyView.


https://ift.tt/2NuFchk

10th International Conference of Jordanian Society of Dermatology, Venereology, Dermatosurgery & Laser, Amman, Kingdom of Jordan

Dermatologic Therapy, EarlyView.


https://ift.tt/2O6EgRx

Intralesional 5‐fluorouracil to treat extensive molluscum contagiosum in an immunocompromised patient: A novel therapeutic modality

Dermatologic Therapy, EarlyView.


https://ift.tt/2L9D2qE

Clinical features, diagnosis and therapy of pituicytoma: an update

Abstract

Background

Pituicytomas (PTs) are extremely rare, low-grade glial tumors closely related to the neurohypophyseal axis. Definite conclusions concerning the optimal diagnostic and therapeutic approach to these neoplasms are lacking to date, as most of this information has been presented as case reports.

Methods

Retrospective review of case reports published in the scientific literature to date, including a new illustrative example treated in our department.

Results

116 cases were collected. PTs had a higher prevalence in the fifth and sixth decades of life, with a slight male predominance. Main symptoms, which tended to be progressive, included visual field defects and pituitary–hypothalamic dysfunction. Radiologically, PTs were found anywhere along the hypothalamic–pituitary axis mimicking other, more frequent tumors growing in this anatomical region. Surgical treatment included both transcranial or transsphenoidal approaches, and resulted in gross total resection and morbidity rates of 46.8 and 59%, respectively; the latter essentially consisted in anterior and posterior pituitary dysfunction, with limited impact on daily quality of life.

Conclusions

Due to both low frequency and the absence of pathognomonic clinical and/or radiological features, formulating a suspicion diagnosis of PT represents a considerable challenge even for experienced professionals. The indication for treatment should be made on an individual basis, but it is inescapable in the presence of a visual field defect. The surgical approach has to be tailored according to the topography of the tumor and preoperative symptoms; the greatest challenges in accomplishing a gross total removal are represented by the degree of adherence and vascularization of the PT.

https://ift.tt/2LqiGsl

Scholar : These new articles for Canadian Journal of Latin American and Caribbean Studies / Revue canadienne des études latino-américaines et caraïbes are available online

The online platform for Taylor & Francis Online content New for Canadian Journal of Latin American and Caribbean Studies/Revue canadienne des études latino-américaines et caraïbes and online now on Taylor & Francis Online: Original Articles Sujetos de desecho: violencia lenta e inacción ambiental en un botadero minero abandonado de Chile Sebastián Ureta, Florencia Mondaca & Anna Landherr Pages: 1-19 | DOI: 10.1080/08263663.2018.1491685 Do you have original research that relates to present-day Japan and its recent historical development? Contemporary Japan welcomes your submissions. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Spanish Journal of Finance and Accounting / Revista Española de Financiación y Contabilidad are available online

The online platform for Taylor & Francis Online content New for Spanish Journal of Finance and Accounting / Revista Española de Financiación y Contabilidad and online now on Taylor & Francis Online: Errata Erratum Pages: 1-1 | DOI: 10.1080/02102412.2018.1487186 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Activities, Adaptation & Aging are available online

The online platform for Taylor & Francis Online content New for Activities, Adaptation & Aging and online now on Taylor & Francis Online: Original Articles Effects of Tai Chi, Fitness Boxing, and Video Activities on the Balance and Endurance of a Participant with Multiple Sclerosis: A Case Study Mary Lou Schilling, Laura Beattie, Kaitlin Bell, Olivia Jacques & Courtney Lyon Pages: 1-12 | DOI: 10.1080/01924788.2018.1500054 FREE ACCESS: Health Care for Women International: Research on Women's Health in Africa: Issues, Challenges & Opportunities To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for African Security Review are available online

The online platform for Taylor & Francis Online content New for African Security Review and online now on Taylor & Francis Online: Essay Turning the tides of war: The impact of private military and security companies on Nigeria's counterinsurgency against Boko Haram Caroline Varin Pages: 1-14 | DOI: 10.1080/10246029.2018.1489863 Do you have original research that relates to present-day Japan and its recent historical development? Contemporary Japan welcomes your submissions. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Low-Level EMF Stimulation for Paroxysmal Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Catheter Ablation;   Autonomic Imbalance
Interventions:   Device: Low-level Pulsed EMF;   Device: Sham Stimulation
Sponsor:   Daniel Sohinki
Not yet recruiting

https://ift.tt/2msMpD0

Study to Evaluate Safety & Tolerability of AGI-134 in Solid Tumour

Conditions:   Superficial, Palpable, Unresectable/Metastatic Solid Tumour;   Metastatic Colorectal Cancer;   Squamous Cell Carcinoma of the Head and Neck
Interventions:   Drug: AGI-134;   Drug: AGI-134 + Pembrolizumab
Sponsor:   Agalimmune Ltd.
Not yet recruiting

https://ift.tt/2uPn61K

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8233 in Healthy Male Subjects With Increased Elevated LDL-C Levels.

Condition:   Hypercholesterolemia
Intervention:   Drug: AZD8233
Sponsors:   AstraZeneca;   Parexel
Not yet recruiting

https://ift.tt/2mvStdR

Scholar : CoDesign, Volume 14, Issue 3, September 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content CoDesign, Volume 14, Issue 3, September 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Original Articles Co-constructed imagination space: a multimodal analysis of the interactional accomplishment of imagination during idea-development meetings Brian Lystgaard Due Pages: 153-169 | DOI: 10.1080/15710882.2016.1263668 A participatory product design process with children with autism spectrum disorder Sevi Merter & Deniz Hasırcı Pages: 170-187 | DOI: 10.1080/15710882.2016.1263669 Co-designing with people living with dementia | Paul A. Rodgers Pages: 188-202 | DOI: 10.1080/15710882.2017.1282527 Patient involvement in Danish hospital design Richard Herriott Pages: 203-217 | DOI: 10.1080/15710882.2017.1292295 Persona logical thinking: improving requirements elicitation for multidisciplinary teams Jessy Barré, Stéphanie Buisine & Améziane Aoussat Pages: 218-237 | DOI: 10.1080/15710882.2017.1301959 Nonhumans in participatory design Louis Rice Pages: 238-257 | DOI: 10.1080/15710882.2017.1316409 Corrigendum Correction to: Smith, Bossen and Kanstrup, Participatory design in an era of participation Pages: 258-258 | DOI: 10.1080/15710882.2017.1331613 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Correction to: Age-specific reference values and cut-off points for anti-müllerian hormone in infertile women following a long agonist treatment protocol for IVF

Unfortunately, the first author name was incorrectly published in the original publication. The complete correct name should read as follows.

https://ift.tt/2LyrgSW

Arsenic forms in phytoextraction of this metalloid in organs of 2-year-old Acer platanoides seedlings

Abstract

The aim of the study was to estimate the significance of the role of arsenite (As(III)), arsenate (As(V)), and dimethylarsinic acid (DMA) presence in modified Knop medium in the efficiency of phytoextraction of arsenic (As) in Acer platanoides root, stem, and leaves. The addition of particular As forms in single, double, and triple experimental systems was associated with a lower increase of seedling biomass compared to control plants (system free of As forms addition). Depending on As forms and their concentration in solution, negative symptoms from slight visible changes (inorganic forms separately or jointly), through smaller and discolored leaves (after DMA addition), and finally to their withering (after high DMA addition) were observed. Changes of color and shape for root systems exposed to particular As forms separately or jointly were also observed, in spite of the fact that there were no significant changes in biomass of seedlings growing in all experimental systems. The highest mean concentrations of As in root, stem, and leaves (590, 70, and 140 mg kg⁻¹ dry weight (DW), respectively) were observed in plants growing under different experimental systems. The highest bioconcentration factor values were 10.8 for plants exposed to 0.06 mM of As(III) and DMA, while the highest translocation factor (1.0) was recorded for plants growing under the same As forms (0.6 and 0.06 mM, respectively). The obtained results indicate that the presence of particular As forms not only determines As phytoextraction and transport of this metalloid form but also has a decisive influence on plant morphology and survivability. As regards the practical aspects of phytoremediation, the kind of As forms present in substrate are more important than their total concentration.

https://ift.tt/2JFI0Wm

Dermoscopy of Cutaneous Lymphoproliferative Disorders: Where Are We Now?

The prompt identification of cutaneous lymphoproliferative disorders (CLD) has always been a challenge in dermatological practice, due to the rarity of this group of diseases, the heterogeneity in clinical presentation, and plenty of variants described in the literature so far. The strict cooperation between dermatologist and pathologist is the key element for the correct diagnosis of CLD deriving from the perfect integration of clinical and histopathological features. In this complex context, dermoscopy could play an adjuvant role in the achievement of the diagnosis, as it fits itself as the third diagnostic tool in the paraphernalia of the dermatologist between the clinical and histopathological examination. This review provides the state of art of dermoscopy of CLD.
Dermatology

https://ift.tt/2LoWWxk

Scholar : Australian Journal of Political Science, Volume 53, Issue 3, September 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Australian Journal of Political Science, Volume 53, Issue 3, September 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Jobs, crime, proximity and boats: explaining Australian public attitudes to immigrant numbers Ferran Martinez i Coma & Rodney Smith Pages: 271-289 | DOI: 10.1080/10361146.2018.1450357 Partisanship and the gender gap: support for gender quotas in Australia Katrine Beauregard Pages: 290-319 | DOI: 10.1080/10361146.2018.1449802 Understanding the divergent development of the ministerial office in Australia and the UK Maria Maley Pages: 320-335 | DOI: 10.1080/10361146.2018.1450356 Competitive federalism and workers' compensation: do states race to the bottom? Robyn Hollander & Louise Thornthwaite Pages: 336-352 | DOI: 10.1080/10361146.2018.1477115 Bringing lessons from crisis management into the realm of wicked problems George Carayannopoulos & Allan McConnell Pages: 353-369 | DOI: 10.1080/10361146.2018.1450067 Bringing politics into class analysis: state power and class formation in post-Mao China Yingjie Guo Pages: 370-384 | DOI: 10.1080/10361146.2018.1477114 Review Essay The politics of marriage policy Naomi Cahn & June Carbone Pages: 385-397 | DOI: 10.1080/10361146.2018.1473085 A century of Wilsonianism: a review essay James Cotton Pages: 398-407 | DOI: 10.1080/10361146.2018.1477916 Corrigendum Corrigendum Pages: i-i | DOI: 10.1080/10361146.2018.1471018 Do you have original research that relates to present-day Japan and its recent historical development? Contemporary Japan welcomes your submissions. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

The 10 fundamental principles of lay resuscitation: Recommendations by the German Resuscitation Council

No abstract available

https://ift.tt/2Lrmx8w

Anatomical Study of Percutaneous Trigeminal Compressive Balloon Positioning on Merged 3-D Rotational X-Ray and Preprocedural Magnetic Resonance Imaging

Background: Percutaneous trigeminal rhizotomy or balloon compression for trigeminal neuralgia carries a potential risk for the brainstem, the carotid artery, and the basilar artery. Objective: To detail the relation of critical neural and vascular structures to expanded balloons used for percutaneous compression of the trigeminal ganglion. Method: A retrospective analysis of preprocedural magnetic resonance imaging (MRI) and procedural X-ray-based imaging for 9 patients detailed balloon proximity to the brainstem, carotid artery, and basilar artery. Results: Balloons extended 10.96 ± 5.54 mm (mean ± SD) posterior to the clival line. The average distance from the balloon to the brainstem was 6.89 mm, and that to the basilar artery was 12.12 mm (range: 0–18.2). The medial edge of the balloon was an average distance of 1.39 mm from the baseline position of the carotid lumen. Conclusion: Preprocedural MRI, merged with 3-D rotational angiography suite imaging, detailed the proximity of the balloon to critical neural and vascular structures. Our study found that the standard technique for percutaneous trigeminal compression, with balloon placement at an average depth of 10.96 mm posterior to the clival line, on average, provided an additional 6.89 mm of space before the brainstem would have been encountered, demonstrating safe positioning.
Stereotact Funct Neurosurg

https://ift.tt/2uOcrEt

Data-Driven Prediction of the Therapeutic Window during Subthalamic Deep Brain Stimulation Surgery

Background: Moving from awake surgery under local anesthesia to asleep surgery under general anesthesia will require to precisely predict the outcome of deep brain stimulation. Objective: To propose a data-driven prediction of both the therapeutic effect and side effects of the surgery. Methods: The retrospective intraoperative data from 30 patients operated on in the subthalamic nucleus were used to train an artificial neural network to predict the deep brain stimulation outcome. A leave-one-out validation was undertaken to give a predictive performance that would reflect the performance of the predictive model in clinical practice. Three-dimensional coordinates and the amount of current of the electrodes were used to train the model. Results: 130 electrode positions were reviewed. The areas under the curve were 0.902 and 0.89 for therapeutic and side effects, respectively. The mean sensitivity and specificity were 93.07% (SD 0.95) and 69.24% (SD 5.27) for the therapeutic effect, 73.47% (SD 10.55) and 91.82% (SD 0.12) for the side effect. Conclusion: Data-driven prediction could be an additional modality to predict deep brain stimulation outcome. Further validation is needed to precisely use this method for performing surgery under general anesthesia.
Stereotact Funct Neurosurg

https://ift.tt/2LryPxR

Radiotherapy, tumor mutational burden, and immune checkpoint inhibitors: time to do the math

https://ift.tt/2L9Vv6h

Bone involvement and mineral metabolism in Williams’ syndrome

Abstract

Context

The previous studies suggested a possible increased risk of hypercalcaemia and reduced bone mineral density (BMD) in Williams' syndrome (WS). However, an extensive study regarding bone metabolism has never been performed.

Objective

To investigate bone health in young adults with WS.

Design

Cross-sectional study.

Settings

Endocrinology and Metabolic Diseases and Medical Genetic Units.

Patients

29 WS young adults and 29 age- and sex-matched controls.

Main outcome measures

In all subjects, calcium, phosphorus, bone alkaline phosphatase (bALP), parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHVitD), osteocalcin (OC), carboxyterminal cross-linking telopeptide of type I collagen (CTX), 24-h urinary calcium and phosphorus, femoral-neck (FN) and lumbar-spine (LS) BMD and vertebral fractures (VFx) were assessed. In 19 patients, serum fibroblast growth factor-23 (FGF23) levels were measured.

Results

WS patients showed lower phosphorus (3.1 ± 0.7 vs 3.8 ± 0.5 mg/dL, p = 0.0001) and TmP/GFR (0.81 ± 0.32 vs 1.06 ± 0.25 mmol/L, p = 0.001), and an increased prevalence (p = 0.005) of hypophosphoremia (34.5 vs 3.4%) and reduced TmP/GFR (37.9 vs 3.4%). Moreover, bALP (26.3 ± 8.5 vs 35.0 ± 8.0 U/L), PTH (24.5 ± 12.6 vs 33.7 ± 10.8 pg/mL), OC (19.4 ± 5.3 vs 24.5 ± 8.7 ng/mL), and FN-BMD (− 0.51 ± 0.32 vs 0.36 ± 0.32) were significantly lower (p < 0.05), while CTX significantly higher (401.2 ± 169.3 vs 322.3 ± 122.4 pg/mL, p < 0.05). Serum and urinary calcium and 25OHVitD levels, LS-BMD and VFx prevalence were comparable. No cases of hypercalcemia and suppressed FGF23 were documented. Patients with low vs normal phosphorus and low vs normal TmP/GFR showed comparable FGF23 levels. FGF23 did not correlate with phosphorus and TmP/GFR values.

Conclusions

Adult WS patients have reduced TmP/GFR, inappropriately normal FGF23 levels and an uncoupled bone turnover with low femoral BMD.

https://ift.tt/2O24Lao

Facile fabrication of sodium styrene sulfonate-grafted ethylene-vinyl alcohol copolymer as adsorbent for ammonium removal from aqueous solution

Abstract

An adsorbent EVOH-g-SSS(H) was successfully synthesized for ammonium removal by one-step grafting SSS onto EVOH particles directly using radiation-induced grafting technique followed by protonation. The effects of adsorbed dose and monomer concentration on grafting yield were investigated. The adsorption behaviors of the EVOH-g-SSS(H) towards ammonium ions (NH₄⁺) were discussed. The adsorption isotherm of NH₄⁺ was a followed Langmuir model with the maximum adsorption capacity of 22.53 mg/g at optimal pH 6.5. For comparison, adsorption kinetics towards NH₄⁺ removal by EVOH-g-SSS(H) and commercially available DIAION PK228 were studied. Both adsorbents were better obeyed pseudo-second-order mode. EVOH-g-SSS(H) for NH₄⁺ uptake was faster than PK228 and reached equilibrium within 5 min. Column experiment showed that the column adsorption capacity of EVOH-g-SSS(H) adsorbent was 9.69 mg/g-ad at SV 10 h⁻¹. The NH₄⁺ concentration in outlet solution can maintain at a very low level even SV was as high as 800 h⁻¹. The elution curve showed the EVOH-g-SSS(H) adsorbent can be regenerated using 1 M HCl. Besides, the removal percentage of NH₄⁺ can be 97% from actual groundwater within 1 min. Such high adsorption efficiency of EVOH-g-SSS(H) makes it to be employed as an adsorbent for NH₄⁺ removal in practical application.

https://ift.tt/2uOHLmA

Optimal water resource management for sustainable development of the chemical industrial park under multi-uncertainty and multi-pollutant control

Abstract

Two major concerns over the chemical industrial park (CIP) operations are high consumption of water resources and large amount of pollutant emissions. This study develops an interval chance-constrained programming model for industrial water resources management (ICCP-IWM) with consideration of multi-uncertainty and multi-environmental constraints. Uncertainties expressed as intervals and probability distributions are merged in the ICCP-IWM framework. The developed model is used to solve a real-world water resource management problem in the Shenyang Chemical Industrial Park to demonstrate its capacity and effectiveness, where the objective is to minimize the system cost of water pathways and pollutant-emission control under a series of constraints. Interval solutions with respect to water resources allocation, wastewater management, and pollutant emissions could be generated. Results indicate that a lower violation risk leads to an increased strictness of the constraints, then to a higher system cost; conversely, a higher violation risk results in a lower system cost, at the expense of an increase in the risk. These findings would be recommended by the decision-makers because of their applicability for practical decision process providing the optimal strategy for sustainable water resource management under multiple uncertainties.

https://ift.tt/2mAZMBn