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Σάββατο 4 Αυγούστου 2018

Scholar : intitle:laryngeal - new results

Effect of miR-363 on the proliferation, invasion and apoptosis of laryngeal cancer by targeting Mcl-1.

WT Feng, R Yao, LJ Xu, XM Zhong, H Liu, Y Sun… - European review for …, 2018
To investigate the potential effect of miR-363 on the development of laryngeal cancer
and to reveal the relevant mechanism. The expression level of miR-363 was
detected in laryngeal cancer tissues and cells (TU-177), respectively. Luciferase …
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Laryngeal Mask Airway Versus Other Airway Devices for Anesthesia in Children With an Upper Respiratory Tract Infection: A Systematic Review and Meta-analysis of …

ALR de Carvalho, RB Vital, CCS de Lira, IB Magro… - Anesthesia & Analgesia, 2018
There is an association between upper respiratory tract infection (URTI) and an
increased incidence of perioperative respiratory adverse events (PRAEs), which is a
major risk for morbidity during pediatric anesthesia. The aim of the present study was …
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"Hidden in Plain Sight": A Descriptive Review of Laryngeal Vestibule Closure

A Vose, I Humbert - Dysphagia, 2018
A major emphasis in the evaluation of swallowing is to identify physiological
abnormalities in swallowing that contribute to or explain unsafe swallowing (ie,
ingested material enters the trachea; post-swallow residue in the pharynx) …
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Neck midline identification with the laryngeal handshake method

H Oh, HG Ryu - Acta Anaesthesiologica Scandinavica
Correspondence: Ho Geol Ryu, Department of Anesthesiology and Pain Medicine, Seoul
National University Hospital, Seoul National University College of Medicine, 101,
Daehak‐ro, Jongno‐gu, Seoul 03080, Korea (E-mail address:hogeol@gmail.com) …
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Extreme long‐term voice outcomes after concurrent chemoradiotherapy for advanced non‐laryngeal head and neck cancer: eight year post treatment analysis

C Davies‐Husband, J Murphy, C Kelly, M Drinnan… - Clinical Otolaryngology
Background The long‐term effect of concurrent chemoradiation on voice outcomes in
the context of non‐laryngeal head and neck cancer is not established. Methods A
prospective, observational study to evaluate the voice quality in disease free patients …
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[PDF] Case report of metastatic colon adenocarcinoma with laryngeal deposits

S Garvie, P Gana, J Uraiby
The larynx is known to be a very rare site for metastases of tumours of various
regions due to its terminal position in the lymphatic circulation system. The last case
of a massive transglottic deposit of the larynx with associated classical symptoms …
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Scholar : ΑΠΟΚΑΤΑΣΤΑΣΗ - νέα αποτελέσμ

[PDF] Καρκίνος των οστών και νοσηλευτικές παρεμβάσεις

Β Καρκασίνα, Μ Ναυρόζογλου - 2018
… σημαντικό ρόλο τόσο στη διάγνωση και θεραπεία, όσο και στην ψυχοκοινωνική
αποκατάσταση του ασθενή αλλά και του οικογενειακού του περιβάλλοντος, ώστε να
μπορέσουν να κατανοήσουν τον καρκίνο και τις δυσκολίες του, να βελτιώσουν το …
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[PDF] Βιογραφική έρευνα εκπαιδευτικών που εργάστηκαν σε σχολεία του εξωτερικού στα πλαίσια της διαρροής επιστημονικού κεφαλαίου (BrainDrain) και επέστρεψαν στην …

Α Μεκάση - 2018
Page 1. 1 ΠΑΝΕΠΙΣΤΗΜΙΟ ΔΥΤΙΚΗΣ ΜΑΚΕΔΟΝΙΑΣ ΠΑΙΔΑΓΩΓΙΚΗ ΣΧΟΛΗ
ΔΙΑΤΜΗΜΑΤΙΚΟ ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ Επιστήμες της Αγωγής:
Επαγγελματική Μάθηση και Καινοτομίες στην Εκπαίδευση Διπλωματική …
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[PDF] Αξιοποίηση της τεχνολογίας για τη βελτίωση της λειτουργικότητας ασθενών με χρόνιες παθήσεις: η περίπτωση των νεφροπαθών

Δ Νικολίνα - 2018
… Ο ιατρός θεωρείται ως ο ιδιοκτήτης εξειδικευμένων γνώσεων ώστε να εφαρμόζεται η
αποτελεσματικότερη θεραπεία, ο ασθενής όμως είναι ο μόνος υπεύθυνος για συμμόρφωση
στη θεραπεία με στόχο την πλήρη αποκατάστασή του. (Kutner, nd) Page 18. 18 …
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[PDF] Επενδύσεις στον τουρισμό ευεξίας-Ανάπτυξη ενός business plan

Κ Στυλιαράς, Γ Παππά - 2018
Page 1. Σχολή διοίκησης και οικονομίας Τμήμα διοίκησης επιχειρήσεων Πτυχιακή εργασία
''Επενδύσεις στον τουρισμό ευεξίας - Ανάπτυξη ενός business plan'' Οι φοιτητές: Παππά
Γκλόρια (7945) Στυλιαράς Κωνσταντίνος (8387) Υπεύθυνος καθηγητής: Χαλικιάς Μιλτιάδης …
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[PDF] Ο θρησκευτικός τουρισμός στην Κύπρο

Ε Ιωαννίδου - 2018
Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΔΥΤ ΣΧΟΛΗ ΔΙΟΙΚΗΤΙΚΩΝ, ΟΙΚΟΝΟΜΙΚ TMHMA
ΔΙΟΙΚΗΣΗΣ ΤΟΥΡΙΣΜΟΥ Ο ΘΡΗΣΚΕΥΤΙΚΟΣ Τ Δρ. ΜΟΙΡΑ ΠΟΛ
ΑΝΕΠΙΣΤΗΜΙΟ ΔΥΤΙΚΗΣ ΑΤΤΙΚΗΣ ΗΤΙΚΩΝ, ΟΙΚΟΝΟΜΙΚΩΝ ΚΑΙ …
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Scholar : ΠΡΟΣΩΠΙΚΟ ΝΕΥΡΟ - νέα αποτελέσματα

[PDF] Καρκίνος των οστών και νοσηλευτικές παρεμβάσεις

Β Καρκασίνα, Μ Ναυρόζογλου - 2018
Page 1. ΚΑΡΚΙΝΟΣ ΟΣΤΩΝ – ΝΟΣΗΛΕΥΤΙΚΕΣ ΠΑΡΕΜΒΑΣΕΙΣ I ΑΝΩΤΑΤΟ ΤΕΧΝΟΛΟΓΙΚΟ
ΙΔΡΥΜΑ Τ.Ε.Ι. ΗΠΕΙΡΟΥ ΣΧΟΛΗ ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ & ΠΡΟΝΟΙΑΣ "ΤΜΗΜΑ
ΝΟΣΗΛΕΥΤΙΚΗΣ" ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ Καρκίνος των Οστών και Νοσηλευτικές Παρεμβάσεις …
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[PDF] Επενδύσεις στον τουρισμό ευεξίας-Ανάπτυξη ενός business plan

Κ Στυλιαράς, Γ Παππά - 2018
Page 1. Σχολή διοίκησης και οικονομίας Τμήμα διοίκησης επιχειρήσεων Πτυχιακή εργασία
''Επενδύσεις στον τουρισμό ευεξίας - Ανάπτυξη ενός business plan'' Οι φοιτητές: Παππά
Γκλόρια (7945) Στυλιαράς Κωνσταντίνος (8387) Υπεύθυνος καθηγητής: Χαλικιάς Μιλτιάδης …
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Scholar : ΔΥΣΠΝΟΙΑ - νέα αποτελέσματα

[PDF] Αξιοποίηση της τεχνολογίας για τη βελτίωση της λειτουργικότητας ασθενών με χρόνιες παθήσεις: η περίπτωση των νεφροπαθών

Δ Νικολίνα - 2018
Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΔΥΤΙΚΗΣ ΑΤΤΙΚΗΣ Σχολή Διοικητικών, Οικονομικών και
Κοινωνικών Επιστημών Τμήμα Διοίκησης Επιχειρήσεων "Πρόγραμμα Μεταπτυχιακών
Σπουδών Διοίκηση Μονάδων Υγείας και Κοινωνικής Πρόνοιας" …
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Scholar : ΧΗΜΕΙΟΘΕΡΑΠΕΙΑ - νέα αποτελέ

[PDF] Καρκίνος των οστών και νοσηλευτικές παρεμβάσεις

Β Καρκασίνα, Μ Ναυρόζογλου - 2018
… μικρό ποσοστό επιβίωσης. Η θεραπεία του έγκειται στην ακτινοθεραπεία και τη
χημειοθεραπεία, ενώ πολύ συχνά το προσβεβλημένο μέλος αντικαθίσταται με χειρουργική
παρέμβαση από πρόσθετο μέλος ή ακρωτηριάζεται. Η διαχείριση και …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.



Scholar : ΦΩΝΗΤΙΚΕΣ ΧΟΡΔΕΣ - νέα αποτελέσματα

[PDF] Ενσυναίσθηση και προτιμήσεις στη μουσική

Ά Λεζγίδου - 2018
… εξαιρετικά εξελιγμένων μορφών μουσικής όπως η συμφωνική, η φούγκα,
η σονάτα, τα μικτά φωνητικά και οργανικά στυλ όπως η όπερα και η καντάτα …
Από την μεγάλη έκταση και θεατρικότητα της φωνής του Iron Maiden μέχρι …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.



Scholar : ΑΚΤΙΝΟΘΕΡΑΠΕΙΑ - νέα αποτελέ

[PDF] Καρκίνος των οστών και νοσηλευτικές παρεμβάσεις

Β Καρκασίνα, Μ Ναυρόζογλου - 2018
… Αποτελέσματα: Ο καρκίνος των οστών αποτελεί μια σπάνια καρκινική μορφή με μικρό
ποσοστό επιβίωσης. Η θεραπεία του έγκειται στην ακτινοθεραπεία και τη χημειοθεραπεία,
ενώ πολύ συχνά το προσβεβλημένο μέλος αντικαθίσταται με …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.



Scholar : New articles have been published for Journal of Natural History, Volume 52, Issue 29-30

Taylor & Francis Online - The new journals and reference work platform for Taylor & Francis
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The following articles have been newly published in the issue Journal of Natural History, Volume 52, Issue 29-30 on Taylor & Francis Online:

Original Articles
First record of the genus Leptodactylus (Anura: Leptodactylidae) in Cuba: Leptodactylus fragilis, a biological invasion?
Tomás M. Rodríguez-Cabrera, L. Yusnaviel García-Padrón, Andrés R. Acosta Galvis, Rafael O. de Sá, Roberto Alonso Bosch
Pages: 1883-1892 | DOI: 10.1080/00222933.2018.1498549

Distribution of the meadow lizard in Europe and its realized ecological niche model
Jelena Ćorović, Miloš Popović, Dan Cogălniceanu, Miguel A. Carretero, Jelka Crnobrnja-Isailović
Pages: 1909-1925 | DOI: 10.1080/00222933.2018.1502829

The issue is in progress. To view all articles already published in this issue, please visit:
https://www.tandfonline.com/toc/tnah20/52/29-30

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Association between CTLA-4 + 49A > G and – 318C > T single-nucleotide polymorphisms and susceptibility to thyroid neoplasm

Abstract

Purpose

Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4 or CD152) is among the immune checkpoint molecules and its abnormal expression in cancer predisposed individuals might make the person more susceptible to tumor initiation and progression. Considering the implication of single-nucleotide polymorphisms (SNPs) in CTLA-4 gene expression and probably protein function, one can assume the involvement of these SNPs in neoplastic diseases. rs5742909 ( − 318C > T) and rs231775 ( + 49 A > G) are among the most commonly studied SNPs and have been considered as genetic factors related to thyroid diseases. In this cross-sectional study, we aimed to elucidate the association between these SNPs and susceptibility to various types of thyroid cancers.

Methods

We investigated the genetic polymorphisms of − 318C > T and + 49 A > G in the CTLA-4 gene by means of ARMS-PCR and RFLP-PCR, respectively, in 167 patients with thyroid carcinomas (papillary, follicular, and anaplastic). The results were then compared with a group of 100 age-sex matched healthy individuals.

Results

A statistically significant association was observed between the presence of G allele in + 49 A > G locus and thyroid carcinoma, when comparing cases and controls (OR = 2.10; 95% CI = 1.35–3.28; P = 0.001) and the frequency of heterozygotes (AG) was higher than homozygotes for allele A (AA), in patients with and papillary thyroid carcinoma (PTC). Regarding Hashimoto's thyroiditis, the frequencies of A allele and AA genotype in PTC patients were higher than Hashimoto patients with no history of cancer (OR = 4.67, 95% CI = 2.70–8.08, P < 0.0001; and, OR = 4.68, 95% CI = 1.84–11.91, P = 0.0012; respectively). However; we observed no difference among allele/genotype frequencies in regards to locus – 318C > T.

Conclusion

In this study, we observed that G allele in + 49 A > G and possibly lower expression of mutated CTLA-4 molecule, is associated with higher susceptibility to thyroid carcinoma. Although the G allele frequency was higher in thyroid cancer patients, when justified for the presence of lymphocytic thyroiditis, the presence of A allele seemed to increase the odds for PTC in patients with Hashimoto's disease.



https://ift.tt/2MezQX9

Association between CTLA-4 + 49A > G and – 318C > T single-nucleotide polymorphisms and susceptibility to thyroid neoplasm

Abstract

Purpose

Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4 or CD152) is among the immune checkpoint molecules and its abnormal expression in cancer predisposed individuals might make the person more susceptible to tumor initiation and progression. Considering the implication of single-nucleotide polymorphisms (SNPs) in CTLA-4 gene expression and probably protein function, one can assume the involvement of these SNPs in neoplastic diseases. rs5742909 ( − 318C > T) and rs231775 ( + 49 A > G) are among the most commonly studied SNPs and have been considered as genetic factors related to thyroid diseases. In this cross-sectional study, we aimed to elucidate the association between these SNPs and susceptibility to various types of thyroid cancers.

Methods

We investigated the genetic polymorphisms of − 318C > T and + 49 A > G in the CTLA-4 gene by means of ARMS-PCR and RFLP-PCR, respectively, in 167 patients with thyroid carcinomas (papillary, follicular, and anaplastic). The results were then compared with a group of 100 age-sex matched healthy individuals.

Results

A statistically significant association was observed between the presence of G allele in + 49 A > G locus and thyroid carcinoma, when comparing cases and controls (OR = 2.10; 95% CI = 1.35–3.28; P = 0.001) and the frequency of heterozygotes (AG) was higher than homozygotes for allele A (AA), in patients with and papillary thyroid carcinoma (PTC). Regarding Hashimoto's thyroiditis, the frequencies of A allele and AA genotype in PTC patients were higher than Hashimoto patients with no history of cancer (OR = 4.67, 95% CI = 2.70–8.08, P < 0.0001; and, OR = 4.68, 95% CI = 1.84–11.91, P = 0.0012; respectively). However; we observed no difference among allele/genotype frequencies in regards to locus – 318C > T.

Conclusion

In this study, we observed that G allele in + 49 A > G and possibly lower expression of mutated CTLA-4 molecule, is associated with higher susceptibility to thyroid carcinoma. Although the G allele frequency was higher in thyroid cancer patients, when justified for the presence of lymphocytic thyroiditis, the presence of A allele seemed to increase the odds for PTC in patients with Hashimoto's disease.



https://ift.tt/2MezQX9

Παρασκευή 3 Αυγούστου 2018

Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria

AbstractBackground.For clinically appropriate early‐stage breast cancer patients, reflex criteria for Oncotype DX ordering ("the intervention") were implemented at our comprehensive cancer center, which reduced time‐to‐adjuvant chemotherapy initiation. Our objective was to evaluate Oncotype DX ordering practices and chemotherapy use before and after implementation of the intervention.Materials and Methods.We examined medical records for 498 patients who had definitive breast cancer surgery at our center. The post‐intervention cohort consisted of 232 consecutive patients who had Oncotype DX testing after reflex criteria implementation. This group was compared to a retrospective cohort of 266 patients who were diagnosed and treated prior to reflex criteria implementation, including patients who did and did not have Oncotype DX ordered. Factors associated with Oncotype DX ordering pre‐ and post‐intervention were examined. We used multivariate logistic regression to evaluate factors associated with chemotherapy receipt among patients with Oncotype DX testing.Results.The distribution of Oncotype DX scores, the proportion of those having Oncotype DX testing (28.9% vs. 34.1%) and those receiving chemotherapy (14.3% vs. 19.4%), did not significantly change between pre‐ and post‐intervention groups. Age ≤65 years, stage II, grade 2, 1–3+ nodes, and tumor size >2 cm were associated with higher odds of Oncotype DX testing. Among patients having Oncotype DX testing, node status and Oncotype DX scores were significantly associated with chemotherapy receipt.Conclusion.Our criteria for reflex Oncotype DX ordering appropriately targeted patients for whom Oncotype DX would typically be ordered by providers. No significant change in the rate of Oncotype DX ordering or chemotherapy use was observed after reflex testing implementation.Implications for Practice.This study demonstrates that implementing multidisciplinary consensus reflex criteria for Oncotype DX ordering maintains a stable Oncotype DX ordering rate and chemotherapy rate, mirroring what was observed in a specific clinical practice, while decreasing treatment delays due to additional testing. These reflex criteria appropriately capture patients who would likely have had Oncotype DX ordered by their providers and for whom the test results are predicted to influence management. This intervention serves as a potential model for other large integrated, multidisciplinary oncology centers to institute processes targeting patient populations most likely to benefit from genomic assay testing, while mitigating treatment delays.

https://ift.tt/2Oa4z8t

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