Ιατρικά Άρθρα

Δευτέρα 6 Αυγούστου 2018

Scholar : Molecular Medicine Reports - Volume:18 Number:3

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TABLE OF CONTENTS

September-2018
Volume 18
Issue 3

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Oncostatin M promotes the osteogenic differentiation of mouse MC3T3‑E1osteoblasts through the regulation of monocyte chemotactic protein‑1 Wenbiao Zheng, Junhui Guan View Abstract ❯
Investigation of the role of cullin 4A overexpression in human liver cancer Gang Chen, Xiongqi Zhao, Zedan Tan, Dongdong Wang, Ding Luo, Peiyao Zhang, Jun Cao, Fan Wang, Qiyu Liu, Li Li View Abstract ❯
Activation of the KEAP1‑NRF2‑ARE signaling pathway reduces oxidative stress in Hep2 cells Changjiang Li, Lei Cheng, Haitao Wu, Peijie He, Yanping Zhang, Yue Yang, Jian Chen, Min Chen View Abstract ❯























































































































Aucubin suppresses Titanium particles‑mediated apoptosis of MC3T3‑E1 cells and facilitates osteogenesis by affecting the BMP2/Smads/RunX2 signaling pathway Ziguan Zhu, Qingping Xie, Yazeng Huang, Shuijun Zhang, Yu Chen View Abstract ❯
miR‑200b‑3p inhibits proliferation and induces apoptosis in colorectal cancer by targeting Wnt1 Lijuan Chen, Xiangqun Wang, Yunhua Zhu, Jian Zhu, Qingzhong Lai View Abstract ❯
Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis Jing Li, Zhongjun Ding, Yue Yang, Baohong Mao, Yanxia Wang, Xiaoying Xu View Abstract ❯
Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells Cheng Xiang, Qiu‑Ping Xie View Abstract ❯
Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats Tingyu Yang, Yani Liu, Xixi Huang, Rui Zhang, Chunxiao Yang, Jiali Zhou, Yu Zhang, Jing Wan, Shaojun Shi View Abstract ❯
SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway Jiang Yuan, Lei Zeng, Yanpeng Sun, Na Wang, Qiang Sun, Zhaohui Cheng, Yunfu Wang View Abstract ❯
miR‑185‑5p inhibits F‑actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE Chonggao Yin, Guoxin Zhang, Ruimei Sun, Xinting Pan, Xuewen Wang, Hongli Li, Yunbo Sun View Abstract ❯
Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing Dong‑Yue Wen, Deng‑Hua Pan, Peng Lin, Qiu‑Yan Mo, Yun‑Peng Wei, Yi‑Huan Luo, Gang Chen, Yun He, Jun‑Qiang Chen, Hong Yang View Abstract ❯
Comprehensive analysis of gene expression profiles provides insight into the pathogenesis of Crohn's disease Lumin Bo, Hongyu Fu, Junchi Yang View Abstract ❯
Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis Guangda Xin, Rui Chen, Xiaofei Zhang View Abstract ❯
MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10 Jinhui Liu, Yi Jiang, Yicong Wan, Shulin Zhou, Sunita Thapa, Wenjun Cheng View Abstract ❯
Analysis of non‑alcoholic fatty liver disease microRNA expression spectra in rat liver tissues Jiao Nie, Chang‑Ping Li, Jue‑Hong Li, Xia Chen, Xiaoling Zhong View Abstract ❯
Parathyroid hormone 1‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway Xiao‑Ying Wang, Li‑Yan Jiao, Jing‑Lan He, Zhi‑An Fu, Ru‑Jun Guo View Abstract ❯
MiR‑500a‑5p promotes glioblastoma cell proliferation, migration and invasion by targeting chromodomain helicase DNA binding protein 5 Zhiyong Liu, Danying Su, Xiuying Qi, Jing Ma View Abstract ❯
Kaempferol inhibits interleukin‑1β stimulated matrix metalloproteinases by suppressing the MAPK‑associated ERK and P38 signaling pathways Xiaojian Huang, Qiyong Pan, Zekai Mao, Pengcheng Wang, Rui Zhang, Xiaohu Ma, Jingyuan Chen, Hongbo You View Abstract ❯
Effect of cellular mass on chondrogenic differentiation during embryoid body formation Michał Stefan Lach, Katarzyna Kulcenty, Karolina Jankowska, Tomasz Trzeciak, Magdalena Richter, Wiktoria Maria Suchorska View Abstract ❯
Candidate genes and microRNAs for glioma pathogenesis and prognosis based on gene expression profiles Chen Xie, Meng Xu, Dejuan Lu, Weiguang Zhang, Laizang Wang, Hongwei Wang, Jianhua Li, Fubin Ren, Chao Wang View Abstract ❯
Low‑frequency ultrasound and microbubbles combined with simvastatin promote the apoptosis of MCF‑7 cells by affecting the LATS1/YAP/RHAMM pathway Haige Li, Chen Chen, Dehang Wang View Abstract ❯
'Psoriasis 1' reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways Wen Sun, Yang Gao, Xianhua Yu, Yuan Yuan, Jun Yi, Zhen Zhang, Yuxing Cheng, Yong Li, Xing Peng, Xushan Cha View Abstract ❯
ROS‑mediated autophagy through the AMPK signaling pathway protects INS‑1 cells from human islet amyloid polypeptide‑induced cytotoxicity Guanghao Xia, Tiehong Zhu, Xiaotong Li, Yujing Jin, Jing Zhou, Jinfeng Xiao View Abstract ❯
miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/β-catenin pathway in non-small cell lung cancer Bin Wang, Liwei Sun, Jinduo Li, Rong Jiang View Abstract ❯
Comparison of target volume and clinical effects of four radiotherapy plans for acute lymphoblastic leukemia prior to hematopoietic stem cell transplantation Yalei Lin, Fanyang Kong, Hongfei Li, Dandan Xu, Fei Jia, Xudong Zhang, Baohong Wang, Guowen Li View Abstract ❯
Downregulation of microRNA‑21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM‑1 cells Guang Li, Yanping Song, Gangcan Li, Jingjing Ren, Jia Xie, Yunjie Zhang, Fei Gao, Jiao Mu, Jinqian Dai View Abstract ❯
Short‑term use of atorvastatin affects glucose homeostasis and suppresses the expression of LDL receptors in the pancreas of mice Qi Yu, Fang Wang, Xiaodong Meng, Yiren Gong, Yanli Wang, Cangbao Xu, Siwang Wang View Abstract ❯
Integrative analysis of promising molecular biomarkers and pathways for coronary artery disease using WGCNA and MetaDE methods Shilin Yan View Abstract ❯
MicroRNA‑155 promotes ox‑LDL‑induced autophagy in human umbilical vein endothelial cells by targeting the PI3K/Akt/mTOR pathway Shuangshuang Yin, Shaonan Yang, Xudong Pan, Aijun Ma, Juanjuan Ma, Haotian Pei, Yi Dong, Shu Li, Wei Li, Xinran Bi View Abstract ❯
Alterations in necroptosis during ALDH2‑mediated protection against high glucose‑induced H9c2 cardiac cell injury Tingting Fang, Ruiping Cao, Wenlian Wang, Hongwei Ye, Lin Shen, Zhenghong Li, Junfeng Hu, Qin Gao View Abstract ❯
Identification of a novel idiopathic congenital nystagmus‑causing missense mutation, p.G296C, in the FRMD7 gene Yanghui Xiu, Yihua Yao, Tanchu Yang, Meihua Pan, Hui Yang, Weifang Fang, Feng Gu, Junzhao Zhao, Yihua Zhu View Abstract ❯
Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia Yan‑Fei Li, Xiao‑Yan Chen, Tie‑Chi Lei View Abstract ❯
Eotaxin‑1 and MCP‑1 serve as circulating indicators in response to power frequency electromagnetic field exposure in mice Hualiang Li, Lin Lin, Li Li, Liang Zhou, Shuai Hao, Ying Zhang, Zhenhua Ding View Abstract ❯
Bioinformatics approach reveals the key role of C‑X‑C motif chemokine receptor 2 in endometriosis development Aili Tan, Ruoyu Luo, Hua Liang, Mengru Li, Peng Ruan View Abstract ❯
Long non‑coding RNA HR1 participates in the expression of SREBP‑1c through phosphorylation of the PDK1/AKT/FoxO1 pathway Duan Li, Liwei Guo, Baoguo Deng, Min Li, Tingting Yang, Fan Yang, Zhijun Yang View Abstract ❯
Bioinformatic analysis of microRNA expression in Huntington's disease Xiaoyu Dong, Shuyan Cong View Abstract ❯
miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA Peixia Yang, Jie Xiong, Lin Zuo, Kequn Liu, Houbin Zhang View Abstract ❯
RBP4 regulates trophoblastic cell proliferation and invasion via the PI3K/AKT signaling pathway Hongxia Li, Guangming Cao, Nawei Zhang, Tong Lou, Qiushi Wang, Zhenyu Zhang, Chongdong Liu View Abstract ❯
Corosolic acid reduces 5‑FU chemoresistance in human gastric cancer cells by activating AMPK Jun Beom Park, Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Soyeon Kim, Ji Young Sul View Abstract ❯
Rapid diagnosis of human adenovirus B, C and E in the respiratory tract using multiplex quantitative polymerase chain reaction Yuhong Dou, Yuxia Li, Caifeng Ma, Huijun Zhu, Jikun Du, Helu Liu, Qiong Liu, Rui Chen, Ying Tan View Abstract ❯
Establishment of a novel non‑alcoholic fatty liver disease model using cholesterol‑fed rabbits with reference to the potential role of endoplasmic reticulum stress Yanli Wang, Peng Zhang, Xingli Su, Qi Yu, Yulong Chen, Hua Guan, Enqi Liu, Jianglin Fan View Abstract ❯
Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines Jun Song, Yan Zhou, Yu Gong, Hanyang Liu, Liming Tang View Abstract ❯
Luteolin inhibits angiogenesis of the M2‑like TAMs via the downregulation of hypoxia inducible factor‑1α and the STAT3 signalling pathway under hypoxia Binbo Fang, Xuehai Chen, Minmin Wu, Hongru Kong, Guanyu Chu, Zhenxu Zhou, Chunwu Zhang, Bicheng Chen View Abstract ❯
Sevoflurane attenuates ventilator‑induced lung injury by regulating c‑PLA2 expression Yong Yang, Wen‑Fa Wang, Yan‑Hua Li, Li‑Sha Li, Xin Guo, Rui Liu View Abstract ❯
Astragalin and dihydromyricetin as adjuncts to histidine‑tryptophan‑ketoglutarate cardioplegia enhances protection during cardioplegic arrest Dong Wang, Xinjie Zhang, Daoxu Qu, Jichun Han, Fanqing Meng, Minglei Xu, Qiusheng Zheng View Abstract ❯
Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functions Chunhong Liu, Feng Xing, Yuanying He, Shanshan Zong, Chengfeng Luo, Chunqing Li, Tao Duan, Kai Wang, Qian Zhou View Abstract ❯
MicroRNA‑29a contributes to intracranial aneurysm by regulating the mitochondrial apoptotic pathway Wenjing Zhao, Haifang Zhang, Jin‑Ying Su View Abstract ❯
Tanshinone IIA attenuates paraquat‑induced acute lung injury by modulating angiotensin‑converting enzyme 2/angiotensin‑(1‑7) in rats Yanxia Wang, Huajie Wu, Wen Niu, Jian Chen, Manlin Liu, Xin Sun, Zhichao Li View Abstract ❯
Expression of transmembrane protein 41A is associated with metastasis via the modulation of E‑cadherin in radically resected gastric cancer Bin Lin, Yingming Xue, Chao Qi, Xiangjie Chen, Weizheng Mao View Abstract ❯
PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway Meng Li, Xiang Yang, Shouchuan Wang View Abstract ❯
Spilanthol inhibits TNF‑α‑induced ICAM‑1 expression and pro‑inflammatory responses by inducing heme oxygenase‑1 expression and suppressing pJNK in HaCaT keratinocytes Chun‑Hsun Huang, Li‑Chun Chang, Sindy Hu, Chien‑Yu Hsiao, Shu‑Ju Wu View Abstract ❯
Associations of CXCL16, miR‑146a and miR‑146b in atherosclerotic apolipoprotein E‑knockout mice Ai‑Jun Ma, Xiao‑Yan Zhu, Shao‑Nan Yang, Xu‑Dong Pan, Ting Wang, Yuan Wang, Xing Xiao, Shi‑Hai Liu View Abstract ❯
Network‑based gene function inference method to predict optimal gene functions associated with fetal growth restriction Ke‑Jun Ye, Jie Dai, Ling‑Yun Liu, Meng‑Jia Peng View Abstract ❯
Obtusifolin inhibits high glucose‑induced mitochondrial apoptosis in human umbilical vein endothelial cells Yu Tang, Zhi‑Ying Zhong, Yan‑Feng Liu, Gou‑Tai Sheng View Abstract ❯
Decreased expression of TROAP suppresses cellular proliferation, migration and invasion in gastric cancer Ke Jing, Qinsheng Mao, Peng Ma View Abstract ❯
P2X7 receptor regulates EMMPRIN and MMP‑9 expression through AMPK/MAPK signaling in PMA‑induced macrophages Lu Lin, Shanjun Huang, Zhouyang Zhu, Jibo Han, Zhengxian Wang, Weijian Huang, Zhouqing Huang View Abstract ❯
Differential responses of GC‑1 spermatogonia cells to high and low doses of bisphenol A Yuhua Li, Fei Duan, Xiaoyu Zhou, Hongjie Pan, Runsheng Li View Abstract ❯
Triptolide exhibits antitumor effects by reversing hypermethylation of WIF‑1 in lung cancer cells Xiaoliang Mao, Jichun Tong, Yong Wang, Zheng Zhu, Yajun Yin, Yeming Wang View Abstract ❯
Prevalence of hyperuricemia among the Chinese population of the southeast coastal region and association with single nucleotide polymorphisms in urate‑anion exchanger genes: SLC22A12, ABCG2 and SLC2A9 Xinran Yang, Yingxiu Xiao, Kaixi Liu, Xiaoyang Jiao, Xiaozhe Lin, Yongni Wang, Qiaoxin Zhang View Abstract ❯
Long non‑coding RNA UCA1 promotes papillary thyroid cancer cell proliferation via miR‑204‑mediated BRD4 activation Dong Li, Chuanyou Cui, Jing Chen, Zhifang Hu, Yonghui Wang, Dongyu Hu View Abstract ❯
Long noncoding RNA UCA1 promotes anaplastic thyroid cancer cell proliferation via miR‑135a‑mediated c‑myc activation Yonghui Wang, Zhengguang Hou, Dong Li View Abstract ❯
MicroRNA‑130a inhibits the proliferation, migration and invasive ability of hepatocellular carcinoma cells by downregulating Rho‑kinase 2 Yansong Zheng, Liangguang Xiang, Mingliu Chen, Chunhui Xiang View Abstract ❯
Dysregulation of CD69 by overexpression of microRNA‑367‑3p associated with post‑myocardial infarction cardiac fibrosis Haiyan Hu, Jing Li, Jingfang Zhang View Abstract ❯
Association between the HMGB1/TLR4 signaling pathway and the clinicopathological features of ovarian cancer Caixia Jiang, Xiaoyan Qu, Huihui Ke, Wei Gong, Rong Chen, Weihong Yang, Zhongping Cheng View Abstract ❯
MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin Yongfeng Zhang, Xueqin Wang, Yuehua Zhao View Abstract ❯
MicroRNA‑655 suppresses cell proliferation and invasion in oral squamous cell carcinoma by directly targeting metadherin and regulating the PTEN/AKT pathway Qiang Wang, Longkun Lv, Yuan Li, Honghai Ji View Abstract ❯
[Corrigendum] Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis Haiying Shen, Kiyoon Kim, Yoojung Oh, Kyung Sik Yoon, Hyung Hwan Baik, Sung Soo Kim, Joohun Ha, Insug Kang, Wonchae Choe View Abstract ❯
The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review) Magdalenia Bałkowiec, Radosław B. Maksym, Paweł K. Włodarski View Abstract ❯
Anesthetic agent etiomidate induces apoptosis in N2a brain tumor cell line Hong‑Tao Chen, Jun Zhou, You‑Ling Fan, Chun‑Liang Lei, Bao‑Jin Li, Li‑Xin Fan, Li Xu, Ming Xu, Xiu‑Qin Hu, Zhi‑Ying Yu View Abstract ❯
Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway Zhengyan Wang, Rui Li, Rui Zhong View Abstract ❯
Mutation and expression of ABCA12 in keratosis pilaris and nevus comedonicus Fen Liu, Yao Yang, Yan Zheng, Yan‑Hua Liang, Kang Zeng View Abstract ❯
Alda‑1, an aldehyde dehydrogenase‑2 agonist, improves long‑term survival in rats with chronic heart failure following myocardial infarction Yue Hua, Hongmei Chen, Xinyun Zhao, Min Liu, Wen Jin, Wen Yan, Yifen Wu, Zhangbin Tan, Huijie Fan, Yuting Wu, Lingpeng Xie, Wentong Zhang, Bin Liu, Yingchun Zhou View Abstract ❯
LncRNA and mRNA interaction study based on transcriptome profiles reveals potential core genes in the pathogenesis of human thoracic aortic dissection Yang Li, Nan Yang, Xianbao Zhou, Xuezhi Bian, Genqiang Qiu, Mo Zhang, Huagang Lin, Dingfeng Li View Abstract ❯
Simvastatin improves cerebrovascular injury caused by ischemia‑reperfusion through NF‑κB‑mediated apoptosis via MyD88/TRIF signaling Zhiying Chen, Yuanyuan Xiang, Bing Bao, Xiangbin Wu, Zhongbin Xia, Jianyou You , Hongbing Nie View Abstract ❯
Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways Qiu Liu, Xueke Li, Liang Li, Zhiliang Xu, Jun Zhou, Wei Xiao View Abstract ❯
Glassy carbon electrode modified with G‑MoS2‑Nafion acts as an electrochemical biosensor to determine uric acid in human serum Bo Yan, Dongsheng Wang, Qiang Wang, Xiaolan Lu, Qin Du, Qi Liang, Xingliang Jiang, Xiaolan Guo, Jingguo Zhou, Yan Xing View Abstract ❯
Role of microRNA 146a on the healing of cornea alkali burn treated with mesenchymal stem cells Xu Luo, Jianmin Li, Lihui Yin, Jian Pan, Yang Zhang, Zipei Jiang View Abstract ❯
Therapeutic effect of chitosan on CCl4‑induced hepatic fibrosis in rats Zhong‑Feng Wang, Mao‑Yu Wang, De‑Hai Yu, Yan Zhao, Hong‑Mei Xu, Sheng Zhong, Wen‑Yi Sun, Yu‑Fang He, Jun‑Qi Niu, Pu‑Jun Gao, Hai‑Jun Li View Abstract ❯
MicroRNA‑143‑3p contributes to the regulation of pain responses in collagen‑induced arthritis Ling‑Ling Zhou, Ya‑Mei Zhu, Fei‑Ya Qian, Cheng‑Chen Yuan, Dong‑Ping Yuan, Xue‑Ping Zhou View Abstract ❯
Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats Rong Wu, Ping‑An Yao, Hui‑Lin Wang, Yan Gao, Hai‑Lun Yu, Lei Wang, Xiao‑Hua Cui, Xu Xu, Jian‑Ping Gao View Abstract ❯
Ultrasound‑targeted microbubble destruction‑mediated miR‑205 enhances cisplatin cytotoxicity in prostate cancer cells Dingwen Qin, Haige Li, Honglin Xie View Abstract ❯
Role of autophagy in a model of obesity: A long‑term high fat diet induces cardiac dysfunction Yan Che, Zhao‑Peng Wang, Yuan Yuan, Ning Zhang, Ya‑Ge Jin, Chun‑Xia Wan, Qi‑Zhu Tang View Abstract ❯
Emodin alleviates CCl4‑induced liver fibrosis by suppressing epithelial‑mesenchymal transition and transforming growth factor‑β1 in rats Feng Liu, Jing Zhang, Jianmin Qian, Gang Wu, Zhenyu Ma View Abstract ❯
MNX1 reduces sensitivity to anoikis by activating TrkB in human glioma cells Lai Jiang, Shaojun Chen, Donggang Zhao, Jun Yan, Jiemin Chen, Chunlin Yang, Gang Zheng View Abstract ❯
Silencing Tspan1 inhibits migration and invasion, and induces the apoptosis of human pancreatic cancer cells Jiaxun Tian, Rui Zhang, Haiyan Piao, Xiaoxi Li, Weiwei Sheng, Jianping Zhou, Ming Dong, Xiaobo Zhang, Xiaofei Yan, Wen Shang, Jianfeng Zhao, Lan Xu, Fang Liu, Gang Shi View Abstract ❯
A random forest classifier predicts recurrence risk in patients with ovarian cancer Li Cheng, Lin Li, Liling Wang, Xiaofang Li, Hui Xing, Jinting Zhou View Abstract ❯
Cocaine‑ and amphetamine‑regulated transcript (CART) is associated with dopamine and is protective against ischemic stroke Lili Lin, Da Sun, Jing Chang, Ming Ma, Xiaoying Zhou, Min Zhao, Jian Li View Abstract ❯
Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma Shoubao Gao, Xiaohong Xu, Yue Wang, Wei Zhang, Xingye Wang View Abstract ❯
Screening of exosomal miRNAs derived from subcutaneous and visceral adipose tissues: Determination of targets for the treatment of obesity and associated metabolic disorders Zheng Yang, Zhuying Wei, Xia Wu, Huidi Yang View Abstract ❯
Icariin induces the growth, migration and osteoblastic differentiation of human periodontal ligament fibroblasts by inhibiting Toll-like receptor 4 and NF-κB p65 phosphorylation Hai-Jiang Liu, Xue-Yang Liu, De-Bao Jing View Abstract ❯
The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway Peihong Shen, Junfeng Chen, Min Pan View Abstract ❯
Murine and Chinese cobra venom‑derived nerve growth factor stimulate chondrogenic differentiation of BMSCs in vitro: A comparative study Zhikang Miao, Zhenhui Lu, Shixing Luo, Danqing Lei, Yi He, Huayu Wu, Jinmin Zhao, Li Zheng View Abstract ❯
Exendin‑4 reverses endothelial dysfunction in mice fed a high‑cholesterol diet by a GTP cyclohydrolase‑1/tetrahydrobiopterin pathway Zhiqi Tang, Lijuan Liu, Yujie Guo, Guoxiong Deng, Meixiang Chen, Jinru Wei View Abstract ❯
Role of miR‑449b‑3p in endometriosis via effects on endometrial stromal cell proliferation and angiogenesis Yukai Liu, Jie Chen, Xiaoyong Zhu, Lingli Tang, Xuezhen Luo, Yingli Shi View Abstract ❯
Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271 Nan Li, Chunli Wang, Peng Zhang, Shengyi You View Abstract ❯
Knockdown of long noncoding RNA GHET1 inhibits cell‑cycle progression and invasion of gastric cancer cells Ying Xia, Zhiqiang Yan, Ying Wan, Sixi Wei, Ying Bi, Juanjuan Zhao, Juanjuan Liu, Dezhong Joshua Liao, Hai Huang View Abstract ❯
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway Xueli Shi, Liu Yang, Jun Xie, Yumei Zhao, Junzi Cong, Zhiping Li, Haiyan Li, Xianzhi Cheng, Jinghui Fan View Abstract ❯
Hepatocyte growth factor exerts beneficial effects on mice with type II diabetes‑induced chronic renal failure via the NF‑κB pathway Guiming Cheng, Xun Tang, Jun Zhang View Abstract ❯
Knockdown of miR‑935 increases paclitaxel sensitivity via regulation of SOX7 in non‑small‑cell lung cancer Bing Peng, Chao Li, Peng Cai, Liuyang Yu, Bolin Zhao, Guiming Chen View Abstract ❯
Increased expression of TNFRSF14 indicates good prognosis and inhibits bladder cancer proliferation by promoting apoptosis Yu‑Di Zhu, Ming‑Yue Lu View Abstract ❯
TLR4/MyD88 signaling determines the metastatic potential of breast cancer cells Kunlin Wu, Huihao Zhang, Yajuan Fu, Youzhi Zhu, Lingjun Kong, Ling Chen, Feng Zhao, Liangfei Yu, Xiangjin Chen View Abstract ❯
PPARγ agonist rosiglitazone alters the temporal and spatial distribution of inflammation during abdominal aortic aneurysm formation Wen‑Da Wang, Rui Sun, Yue‑Xin Chen View Abstract ❯
Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway Xiu‑Rong Zhang, Shi‑Yao Wang, Wen Sun, Chao Wei View Abstract ❯
Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats Xiaofeng Ou, Yusi Hua, Xuelian Liao, Cansheng Gong, Yan Kang View Abstract ❯
Icariin promotes the proliferation and differentiation of osteoblasts from the rat mandible by the Wnt/β‑catenin signalling pathway Yue Wang, Ran Wang, Fengqiu Zhang View Abstract ❯
Long noncoding RNA TUG1 promotes cardiac fibroblast transformation to myofibroblasts via miR‑29c in chronic hypoxia Yun Zhu, Zezhou Feng, Zhao Jian, Yingbin Xiao View Abstract ❯
Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes Ji‑Hyun Lee, Hyeon‑Hui Ki, Dae‑Ki Kim, Young‑Mi Lee View Abstract ❯
Decreased SUMOylation of the retinoblastoma protein in keratinocytes during the pathogenesis of vitiligo Miaoni Zhou, Fuquan Lin, Wen Xu, Rong Jin, Aie Xu View Abstract ❯
Shikonin‑mediated inhibition of nestin affects hypoxia‑induced proliferation of pulmonary artery smooth muscle cells Susu He, Jian Lin, Ling Lin, Youzu Xu, Jiaxi Feng View Abstract ❯
Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling Xiaoyun Li, Bojia Peng, Yanbin Pan, Panpan Wang, Kehuan Sun, Xiaotong Lei, Ling Ou, Zhidi Wu, Xiaoguang Liu, Haixia Wang, Haibin He, Shu Mo, Ya Tian, Xunqian Peng, Xiaofeng Zhu, Ronghua Zhang, Li Yang View Abstract ❯
shRNA knockdown of DNA helicase ERCC6L expression inhibits human breast cancer growth Juan Liu, Jing Sun, Qian Zhang, Zhaochong Zeng View Abstract ❯
Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway Yan Zhang, Baoguang Qiao, Fei Gao, Haifeng Wang, Shaohua Miao, Huan Zhao View Abstract ❯
Urate crystals induce macrophage PAF‑AH secretion which is differentially regulated by TGFβ1 and hydrocortisone Darshna Yagnik, Frank Hills View Abstract ❯
NSD2 is downregulated in T2DM and promotes β cell proliferation and insulin secretion through the transcriptionally regulation of PDX1 Suqin Shi, Lu Zhao, Lili Zheng View Abstract ❯
MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1 Guanghong Zhou, Hao Jiang, Liping Ma View Abstract ❯
Increased mitochondrial common deletion in platelets from patients with type 2 diabetes is not associated with abnormal platelet activity or mitochondrial function Ayla Karimova, Yalçin Hacioğlu, Nurten Bahtiyar, Mutlu Niyazoğlu, Fahri Akbaş, Erkan Yilmaz, Turgut Ulutin, Ilhan Onaran View Abstract ❯
Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF‑α‑induced HaCaT cell proliferation and the underlying mechanism in psoriasis Hong Leng, Li Pu, Longjiang Xu, Xin Shi, Jiang Ji, Kun Chen View Abstract ❯

20-22 September, 2018, Metropolitan Hotel, Athens, Greece

23^nd World Congress on Advances in Oncology & 22^th International Symposium on Molecular Medicine

18-19 September 2018, Pre-Congress Workshop:

'MicroRNA Analysis'

28-30 March, 2019, Tawana Hotel, Bangkok, Thailand

23 ^rd International Symposium on Molecular Medicine

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Preliminary evaluation of BioFire FilmArray ® Gastrointestinal Panel for the detection of noroviruses and other enteric viruses from wastewater and shellfish

Abstract

The BioFire FilmArray^® Gastrointestinal Panel was evaluated for the rapid detection of adenovirus, astrovirus, norovirus, rotavirus and sapovirus from influent and effluent wastewater and shellfish. The multiplex BioFire FilmArray^® Gastrointestinal Panel compared well to singleplex qPCR/RT-qPCR methods for the detection of adenovirus, astrovirus, rotavirus and sapovirus from influent and effluent wastewater samples. However, the BioFire FilmArray^® Gastrointestinal Panel showed poor performance for the detection of norovirus, significantly underestimating its presence in wastewater and shellfish samples when compared with the singleplex norovirus GI and GII RT-qPCR assays. Therefore, improvement on detection efficiency for norovirus from environmental and food samples is necessary before using results from the FilmArray^® Gastrointestinal Panel to assess associated public health risks.

https://ift.tt/2MpbB8P

Integrative 3′ Untranslated Region‐Based Model to Identify Patients with Low Risk of Axillary Lymph Node Metastasis in Operable Triple‐Negative Breast Cancer

AbstractBackground.Sentinel lymph node biopsy is the standard surgical staging approach for operable triple‐negative breast cancer (TNBC) with clinically negative axillae. In this study, we sought to develop a model to predict TNBC patients with negative nodal involvement, who would benefit from the exemption of the axillary staging surgery.Materials and Methods.We evaluated 3′ untranslated region (3′UTR) profiles using microarray data of TNBC from two Gene Expression Omnibus datasets. Samples from GSE31519 were divided into training set (n = 164) and validation set (n = 163), and GSE76275 was used to construct testing set (n = 164). We built a six‐member 3′UTR panel (ADD2, COL1A1, APOL2, IL21R, PKP2, and EIF4G3) using an elastic net model to estimate the risk of lymph node metastasis (LNM). Receiver operating characteristic and logistic analyses were used to assess the association between the panel and LNM status.Results.The six‐member 3′UTR‐panel showed a high distinguishing power with an area under the curve of 0.712, 0.729, and 0.708 in the training, validation, and testing sets, respectively. After adjustment by tumor size, the 3′UTR panel retained significant predictive power in the training, validation, and testing sets (odds ratio = 4.93, 4.58, and 3.59, respectively; p < .05 for all). A combinatorial analysis of the 3′UTR panel and tumor size yielded an accuracy of 97.2%, 100%, and 100% in training, validation, and testing set, respectively.Conclusion.This study established an integrative 3′UTR‐based model as a promising predictor for nodal negativity in operable TNBC. Although a prospective study is needed to validate the model, our results may permit a no axillary surgery option for selected patients.Implications for Practice.Currently, sentinel lymph node biopsy is the standard approach for surgical staging in breast cancer patients with negative axillae. Prediction estimation for lymph node metastasis of breast cancer relies on clinicopathological characteristics, which is unreliable, especially in triple‐negative breast cancer (TNBC)—a highly heterogeneous disease. The authors developed and validated an effective prediction model for the lymph node status of patients with TNBC, which integrates 3′UTR markers and tumor size. This is the first 3′UTR‐based model that will help identify TNBC patients with low risk of nodal involvement who are most likely to benefit from exemption axillary surgery.

https://ift.tt/2OhdPYt

Outcome of First‐Line Systemic Treatment for Unresectable Conventional, Dedifferentiated, Mesenchymal, and Clear Cell Chondrosarcoma

AbstractBackground.Chondrosarcoma is a heterogeneous group of primary bone sarcoma with an excellent overall survival after local therapy. However, the small percentage of patients who have no surgical treatment options have a very poor prognosis. We retrospectively collected data from these patients in four sarcoma centers and compared the progression‐free survival (PFS) for the different treatment regimens used for the four chondrosarcoma subtypes.Materials and Methods.Patients diagnosed with unresectable chondrosarcoma in all four major sarcoma centers were included, and data on first‐line systemic therapy were retrospectively collected for analysis.Results.A total of 112 patients were enrolled in this retrospective analysis: 50 conventional, 25 mesenchymal, 34 dedifferentiated, and 3 clear cell chondrosarcoma patients. In conventional chondrosarcoma patients, the longest mean PFS (6.7 months) was found in the group treated with antihormonal therapy. Patients diagnosed with mesenchymal chondrosarcoma were all treated with multidrug chemotherapy, and the mean PFS was 6.7 months. Doxorubicin monotherapy seems to have an unexplained better PFS than doxorubicin‐based combination therapy in patients with dedifferentiated chondrosarcoma (5.5 vs. 2.8 months, respectively; p = .275).Conclusion.Prospective studies need to be conducted based on preclinical work to develop a uniform regimen to treat advanced chondrosarcoma patients according to the diagnosed subtype and improve survival.Implications for Practice.Currently, there are no uniform treatment lines for advanced chondrosarcoma patients, which results in a very diverse group of treatment regimens being used. In this study, the data of 112 patients was collected. It was concluded that some treatment regimens seem to have a better progression‐free survival compared with others, and that these results also differ between the chondrosarcoma subtypes. Prospective studies need to be conducted based on preclinical work to develop a uniform regimen to treat advanced chondrosarcoma patients according to the diagnosed histological subtype to improve their survival.

https://ift.tt/2vp7S4O

Strategies for Recognizing and Managing Immune‐Mediated Adverse Events in the Treatment of Hodgkin Lymphoma with Checkpoint Inhibitors

AbstractThe programmed death‐1 (PD‐1) receptor checkpoint inhibitors nivolumab and pembrolizumab represent an important therapeutic advance in the treatment of relapsed or refractory classical Hodgkin lymphoma (cHL). Clinical trials have shown substantial therapeutic activity and an acceptable safety profile in heavily pretreated patients, resulting in U.S. Food and Drug Administration approval of nivolumab for the treatment of cHL that has relapsed or progressed after either autologous hematopoietic cell transplantation (auto‐HCT) and brentuximab vedotin treatment or three or more lines of systemic therapy (including auto‐HCT), and of pembrolizumab for adult or pediatric patients with refractory cHL or cHL that has relapsed after three or more prior therapies. Mechanistically, anti‐PD‐1 therapy prevents inhibitory signaling through PD‐1 receptors on T cells, thereby releasing a 'block' to antitumor T‐cell responses. However, this disinhibition can also lead to inappropriate T‐cell activation and responses against healthy tissues, resulting in immune‐mediated adverse events (IMAEs) that affect a number of organ systems. The skin, gastrointestinal, hepatic, and endocrine systems are most commonly involved, typically resulting in rash, colitis, abnormal liver enzyme levels, and thyroiditis, respectively. Notably, pneumonitis is a potentially fatal complication of checkpoint inhibitor immunotherapy. Hematologic oncologists who treat cHL with PD‐1 immune checkpoint inhibitors should monitor patients for IMAEs, as early recognition and treatment can rapidly reduce morbidity and mortality. This review focuses on IMAEs during the treatment of relapsed or refractory cHL with nivolumab and pembrolizumab.Implications for Practice.This article highlights the importance of monitoring for immune‐mediated adverse events (IMAEs) in patients with Hodgkin lymphoma (HL) who receive anti‐programmed death‐1 (anti‐PD‐1) therapy, with particular attention given to the recognition and management of such events. The risk of individual IMAEs differs between patients with HL and those with solid tumors, as prior treatments may predispose certain organ systems to specific IMAEs. Accurate and prompt diagnosis of IMAEs is essential for optimal management, allowing PD‐1 inhibitor therapy to be restarted in order to maintain disease control. Potential difficulties, such as distinguishing disease progression from pneumonitis, or colitis from diarrhea, are highlighted to raise clinical awareness.

https://ift.tt/2MonCLQ

Pretreatment 18F‐FDG Uptake Heterogeneity Predicts Treatment Outcome of First‐Line Chemotherapy in Patients with Metastatic Triple‐Negative Breast Cancer

AbstractBackground.Intratumoral heterogeneity of 18F‐fluorodeoxyglucose (18F‐FDG) uptake in primary tumor has proven to be a surrogate marker for predicting treatment outcome in various tumors. However, the value of intraindividual heterogeneity in metastatic diseases remains unknown. The aim of this study was to evaluate pretreatment positron emission tomography/computed tomography (PET/CT) 18F‐FDG‐based heterogeneity for the prediction of first‐line treatment outcome in metastatic triple‐negative breast cancer (mTNBC).Materials and Methods.mTNBC patients from three clinical trials (NCT00601159, NCT01287624, and NCT02341911) with whole‐body 18F‐FDG PET/CT scan before first‐line gemcitabine/platinum were included. Heterogeneity index (HI) and the maximum of FDG uptake (MAX) across total metastatic lesions (‐T) on baseline PET/CT scans were assessed. HI was measured by MAX divided by the minimum FDG uptake across metastatic lesions. Optimal cutoffs were determined by time‐dependent receiver operator characteristics (ROC) analysis. Progression‐free survival (PFS) and overall survival (OS) were estimated by Kaplan‐Meier method and compared by log‐rank test.Results.A total of 42 mTNBC patients were included in this study. The median PFS of patients with high HI‐T (>1.9) and high MAX‐T (>10.5) was significantly shorter than patients with low HI‐T (<1.9; p = .049) and low MAX‐T (<10.5; p = .001). In terms of OS, only high MAX‐T was significant for poorer outcome (p = .013). ROC curve analysis confirmed the predictive value of MAX and HI in mTNBC patients. Area under the ROC curve for MAX‐T and HI‐T was 0.75 and 0.65, indicating a higher predictive accuracy than conventional clinical risk factors.Conclusion.HI and MAX measured among metastatic lesions on pretreatment 18F‐FDG PET/CT scans could be potential predicators for first‐line treatment outcome in patients with mTNBC.Implications for Practice.Intratumoral heterogeneity of 18F‐fluorodeoxyglucose (FDG) uptake in primary tumor has proven to be a robust surrogate predictive marker. A novel positron emission tomography/computed tomography (PET/CT) parameter‐heterogeneity index (HI) to quantify the heterogeneous characteristics of metastatic disease is proposed. Triple‐negative breast cancer (TNBC) is a highly heterogeneous disease and remains a clinical challenge. The predictive performance of HI, along with the maximum FDG uptake (MAX), measured on pretreatment PET/CT scans in patients with metastatic TNBC was evaluated. Results indicate that HI and MAX may serve as applicable imaging predicators for treatment outcome of metastatic TNBC in clinical practice.

https://ift.tt/2McOG3A

Multilevel Factors Affecting Time to Cancer Diagnosis and Care Quality in Botswana

AbstractBackground.Cancer incidence is increasing in Africa, and the majority of patients are diagnosed with advanced disease, limiting treatment options and survival. We sought to understand care patterns and factors contributing to delayed diagnosis and treatment initiation among patients with cancer in Botswana.Patients and Methods.We recruited 20 patients who were enrolled in a prospective cancer cohort in Botswana to a qualitative substudy that explored cancer care pathways and factors affecting cancer care access and quality. We conducted an in‐depth interview with each participant between October 2014 and January 2015, using a a structured interview guide with questions about initial cancer symptoms, previous consultations, diagnosis, and care pathways. Medical records were used to confirm dates or treatment details when needed.Results.Individual and interpersonal factors such as cancer awareness and social support facilitated care‐seeking behaviors. However, patients experienced multiple delays in diagnosis and treatment because of provider and health system barriers. Health system factors, such as misdiagnosis, understaffed facilities, poor referral communication and scheduling, and inadequate laboratory reporting systems, affected access to and quality of cancer care.Conclusion.These findings highlight the need for interventions at the patient, provider, and health system levels to improve cancer care quality and outcomes in Botswana. Results also suggest that widespread cancer education has potential to promote early diagnosis through family and community networks. Identified barriers and facilitators suggest that interventions to improve community education and access to diagnostic technologies could help improve cancer outcomes in this setting.Implications for Practice.The majority (54%) of patients with cancer in Botswana present with advanced‐stage cancer despite universal access to free health care, limiting the options for treatment and decreasing the likelihood of positive treatment outcomes. To reduce time from symptom onset to cancer treatment initiation, causes of delay in cancer care trajectories must be identified. The narratives of the patients interviewed for this study give insight into psychosocial factors, outlooks on disease, lower‐level provider delays, and health system barriers that contribute to substantial delays for patients with cancer in Botswana. Identification of problems and barriers is essential for development of effective interventions to mitigate these factors, in order to improve cancer outcomes in this population.

https://ift.tt/2MlPeRO

10‐Year Results of Therapeutic Ratio by Intensity‐Modulated Radiotherapy Versus Two‐Dimensional Radiotherapy in Patients with Nasopharyngeal Carcinoma

AbstractBackground.The purpose of this study was to verify 10‐year results of survival and late toxicities and assess the ultimate therapeutic ratio of intensity‐modulated radiotherapy (IMRT) versus two‐dimensional radiotherapy (2DRT) in patients with nasopharyngeal carcinoma (NPC).Materials and Methods.We retrospectively reviewed the data from 1,276 patients with nonmetastatic NPC who received IMRT or 2DRT from January 2003 to December 2006.Results.Of the 1,276 patients, 512 were treated with IMRT and 764 with 2DRT. Median follow‐up was 115 months. At 10 years, the IMRT group demonstrated significantly better results than the 2DRT group in local failure‐free survival (L‐FFS; 90% vs. 84%; hazard ratio [HR], 0.57, 95% confidence interval [CI], 0.40–0.81; p = .001), failure‐free survival (FFS; 69% vs. 58%; HR, 0.69, 95% CI, 0.57–0.83; p < .001), and overall survival (OS; 75% vs. 63%; HR, 0.62, 95% CI, 0.51–0.77; p < .001). Subgroup multivariate analyses showed that radiotherapeutic technique (IMRT vs. 2DRT) remained an independent prognostic factor for L‐FFS in the T1 subgroup (HR, 0.30; 95% CI, 0.11–0.80; p = .02); for FFS in the stage II subgroup (HR, 0.42; 95% CI, 0.24–0.73; p = .002); and for OS in the stage I (HR, 0.20; 95% CI, 0.04–0.96; p = .04), stage II (HR, 0.39; 95% CI, 0.21–0.75; p = .004), and stage IVA–B (HR, 0.74, 95% CI, 0.56–0.98; p = .04) subgroups. The incidence of grade 3–4 temporal lobe necrosis, cranial neuropathy, eye damage, ear damage, neck soft tissue damage, trismus, and dry mouth was significantly lower in the IMRT group than in the 2DRT group.Conclusion.IMRT demonstrated an improved ultimate therapeutic ratio compared with 2DRT in patients with NPC after a 10‐year follow‐up, with significant improvement of L‐FFS, FFS, and OS and decrease in most late toxicities.Implications for Practice.The ultimate therapeutic ratio of intensity‐modulated radiotherapy versus two‐dimensional radiotherapy in patients with nasopharyngeal carcinoma is unclear. In this retrospective study of 1,276 patients with nonmetastatic nasopharyngeal carcinoma with a follow‐up of 115 months, intensity‐modulated radiotherapy demonstrated an improved ultimate therapeutic ratio compared with two‐dimensional radiotherapy, with significant improvement of local failure‐free survival, failure‐free survival, and overall survival and decrease in most late toxicities and noncancer deaths. However, distant control remains insufficient with this treatment modality.

https://ift.tt/2McNY6q

Use of Antidepressant Medications Moderates the Relationship Between Depressive Symptoms and Hospital Length of Stay in Patients with Advanced Cancer

AbstractBackground.Among patients with cancer, depressive symptoms are associated with worse clinical outcomes, including greater health care utilization. As use of antidepressant medications can improve depressive symptoms, we sought to examine relationships among depressive symptoms, antidepressant medications, and hospital length of stay (LOS) in patients with advanced cancer.Materials and Methods.From September 2014 to May 2016, we prospectively enrolled patients with advanced cancer who had an unplanned hospitalization. We performed chart review to obtain information regarding documented depressive symptoms in the 3 months prior to admission and use of antidepressant medications at the time of admission. We compared differences in hospital LOS by presence or absence of depressive symptoms and used adjusted linear regression to examine if antidepressant medications moderated these outcomes.Results.Of 1,036 patients, 126 (12.2%) had depressive symptoms documented prior to admission, and 288 (27.8%) were taking antidepressant medications at the time of admission. Patients with depressive symptoms experienced longer hospital LOS (7.25 vs. 6.13 days; p = .036). Use of antidepressant medications moderated this relationship; among patients not on antidepressant medications, depressive symptoms were associated with longer hospital LOS (7.88 vs. 6.11 days; p = .025), but among those on antidepressant medications, depressive symptoms were not associated with hospital LOS (6.57 vs. 6.17 days; p = .578).Conclusion.Documented depressive symptoms prior to hospital admission were associated with longer hospital LOS. This effect was restricted to patients not on antidepressant medications. Future studies are needed to investigate if use of antidepressant medications decreases LOS for patients hospitalized with advanced cancer and the mechanisms by which this may occur.Implications for Practice.This study investigated the prevalence of documented depressive symptoms in patients with advanced cancer in the 3 months prior to an unplanned hospitalization and the prevalence of use of antidepressant medications at time of hospital admission. The relationship of these variables with hospital length of stay was also examined, and it was found that documented depressive symptoms were associated with prolonged hospital length of stay. Interestingly, antidepressant medications moderated the relationship between depressive symptoms and hospital length of stay. These findings support the need to recognize and address depressive symptoms among patients with advanced cancer, with potential implications for optimizing health care utilization.

https://ift.tt/2MlP2SA

Enhancement of the biogas and biofertilizer production from Opuntia heliabravoana Scheinvar

Abstract

Waste Opuntia is an abundant source of biomass to produce biogas and biofertilizer in a small and commercial scale. This crop has a high biomass yield, wide adaptation to diverse climatic zones, rapid growth, and low input requirements. This study aimed to evaluate the combined effect of adjusting C/N ratio and an alkaline pretreatment (AP) of waste Opuntia heliabravoana Scheinvar in the production of biogas and biofertilizer in anaerobic reactors. AP bioreactors produced more biogas than the control (C, without the combined effect of AP); besides, in this process, it was not necessary to use additional water due to the high content of water that is present in the tissue of this crop. On the other hand, both biofertilizers (C and AP) had enssential microbial groups that help to enhance plant nutrition as S-reducers, S-oxidizers, amylolytic, cellulolytic bacteria, anaerobic S-mineralizers, cellulolytic fungi, and P-solubilizers. Also, the AP treatment to help to increase 1.5:1 total nitrogen (TN) concentration decreased the pathogenic microorganisms in the biofertilizer compared to the C treatment. For this reason, Opuntia spp. is a good substrate for production of biogas and biofertilizer with essential nutrients for many crops in area with water scarcity.

https://ift.tt/2ng3DE3

Assessing the impact of climate variability on maize using simulation modeling under semi-arid environment of Punjab, Pakistan

Abstract

Climate change and variability are major threats to crop productivity. Crop models are being used worldwide for decision support system for crop management under changing climatic scenarios. Two-year field experiments were conducted at the Water Management Research Center (WMRC), University of Agriculture Faisalabad, Pakistan, to evaluate the application of CERES-Maize model for climate variability assessment under semi-arid environment. Experimental treatments included four sowing dates (27 January, 16 February, 8 March, and 28 March) with three maize hybrids (Pioneer-1543, Mosanto-DK6103, Syngenta-NK8711), adopted at farmer fields in the region. Model was calibrated with each hybrid independently using data of best sowing date (27 January) during the year 2015 and then evaluated with the data of 2016 and remaining sowing dates. Performance of model was evaluated by statistical indices. Model showed reliable information with phenological stages. Model predicted days to anthesis and maturity with lower RMSE (< 2 days) during both years. Model prediction for biological yield and grain yield were reasonably good with RMSE values of 963 and 451 kg ha⁻¹, respectively. Model was further used to assess climate variability. Historical climate data (1980–2016) were used as input to simulate the yield for each year. Results showed that days to anthesis and maturity were negatively correlated with increase in temperature and coefficient of regression ranged from 0.63 to 0.85, while its values were 0.76 to 0.89 kg ha⁻¹ for grain yield and biological yield, respectively. Sowing of maize hybrids (Pioneer-1543 and Mosanto-DK6103) can be recommended for the sowing on 17 January to 6 February at the farmer field for general cultivation in the region. Early sowing before 17 January should be avoided due to severe reduction in grain yield of all hybrids. A good calibrated CERES-Maize model can be used in decision-making for different management practices and assessment of climate variability in the region.

https://ift.tt/2vHuUmF

Gastric neuroendocrine neoplasm with late liver metastasis

Summary

Gastric neuroendocrine neoplasms (GNENs) are classified into three types according to their aetiology. We present a clinical case of a female patient of 66 years and a well-differentiated (grade 2), type 3 GNEN with late liver metastasis (LM). The patient underwent surgical excision of a gastric lesion at 50 years of age, without any type of follow-up. Sixteen years later, she was found to have a neuroendocrine tumour (NET) metastatic to the liver. The histological review of the gastric lesion previously removed confirmed that it was a NET measuring 8 mm, pT1NxMx (Ki67 = 4%). ⁶⁸Ga-DOTANOC PET/CT reported two LM and a possible pancreatic tumour/gastric adenopathy. Biopsies of the lesion were repeatedly inconclusive. She had a high chromogranin A, normal gastrin levels and negative anti-parietal cell and intrinsic factor antibodies, which is suggestive of type 3 GNEN. She underwent total gastrectomy and liver segmentectomies (segment IV and VII) with proven metastasis in two perigastric lymph nodes and both with hepatic lesions (Ki67 = 5%), yet no evidence of local recurrence. A ⁶⁸Ga-DOTANOC PET/CT was performed 3 months after surgery, showing no tumour lesions and normalisation of CgA. Two years after surgery, the patient had no evidence of disease. This case illustrates a rare situation, being a type 3, well-differentiated (grade 2) GNEN, with late LM. Despite this, it was possible to perform surgery with curative intent, which is crucial in these cases, as systemic therapies have limited efficacy. We emphasise the need for extended follow-up in these patients.

Learning points:

GNENs have a very heterogeneous biological behaviour.

Clinical distinction between the three types of GNEN is essential to plan the correct management strategy.

LMs are rare and more common in type 3 and grade 3 GNEN.

Adequate follow-up is crucial for detection of disease recurrence.

Curative intent surgery is the optimal therapy for patients with limited and resectable LM, especially in well-differentiated tumours (grade 1 and 2).

https://ift.tt/2OMGlCn

Sterol profiles are valuable biomarkers for phenotype expression of Conradi–Hünermann–Happle syndrome with EBP mutations

British Journal of Dermatology, EarlyView.

https://ift.tt/2M1hlsD

Are patients with chronic pruritus more susceptible to social stress than healthy controls? An experimental case–control study

British Journal of Dermatology, EarlyView.

https://ift.tt/2KwZJQv

The quality of online health information on breast augmentation

Women spend years researching breast enlargement prior to deciding, and the majority use the Internet to begin their search. Walden et al. showed the biggest influence on a patient's decision to undergo breast augmentation was her plastic surgeon's website, second only to her own desire to change her appearance. The same study also shows the internet is the primary source of information on complications for patients1. It is crucial that online information provided is accurate, up-to-date and understandable to allow patients to make an informed decision.

https://ift.tt/2M5ZuAO

Effect of Breast Reconstruction Modality on the Development of Postmastectomy Shoulder Morbidity

Background: The aim of this study was to evaluate the impact of breast reconstruction modality on the incidence of shoulder morbidity.Methods: Breast cancer patients who underwent immediate reconstructions using three modalities including tissue expander-implant, latissimus dorsi (LD) pedicled flap, or deep inferior epigastric perforator (DIEP) flap from 2008 to 2013 were analyzed. The cumulative incidence of shoulder morbidity was compared among the reconstruction modalities and risk factor analysis was performed using multivariable analysis.

https://ift.tt/2Mo9xOx

Aspect of brow position changes after bilateral ptosis correction surgery

Increased tonicity of the frontalis muscle lifts the brow to elevate the lid margin to compensate for the drooping eyelid in ptosis. Surgical intervention can alleviate the need to keep the brows elevated with the use of the frontalis muscle. Some studies have reported changes in brow position after ptosis surgery [1,2]. However, this is not a universal phenomenon and some patients experience the persistence of brow elevation even after ptosis surgery [1]. This study was aimed at evaluating the prevalence of brow elevation before and after ptosis surgery and analyzing the change in brow position in each patient.

https://ift.tt/2M90PXi

Inter-operator variability in the sensitivity of sentinel lymph node biopsy for melanoma

Plastic surgery trainees, in some circumstances, can progress to consultant level having performed only 15 generic lymph node surgeries, with no mention specifically of sentinel lymph node biopsy (SLNB) on the training log. The majority of SLNBs carried out for melanoma at our centre since 1999 have been performed by eight surgeons, six of whom had been formally trained and mentored in our unit or previously completed skin cancer fellowships. Two surgeons started performing the procedure without formal training or specialist fellowships.

https://ift.tt/2Mo9xy1

A factor analysis of landscape metrics of particles deposited on leaf surface

Abstract

Particulate matter in the airborne environment is one of the top environmental concerns, as well as reasons of deaths and diverse diseases. Urban green infrastructure can improve the air quality by mitigating particulate matters from airborne environment and provide high spatial monitoring of particles by means of leaf particles as indicators. Three common species in Beijing (ailanthus, ash, and willow) were chosen to represent three different leaf characteristics. Then, we analyzed the correlation relationship of the particle metrics at landscape, class, and patch levels and implemented the principal components analysis and factor analysis. Firstly, at landscape level, metrics are mostly correlated with each other and the correlation relationship of metrics of ailanthus and willow were stronger than that of ash, which has coarse-texture leaves without hair. At class level, most of the metrics were correlated and the correlation relationship of metrics of ailanthus, whose leaves have microgrooves without hair, was weaker than that of ash and willow. At patch level, judging from proximity, the distance between particles from the same range was smaller for particles with complicated shape. Secondly, particles from four ranges were analyzed separately. The shape complexity of particles decreased and increased as the area increased respectively for PM1 (diameter ≤ 1 μm) and large particles (diameter ≥ 10 μm). Two principle components were identified for landscape and class levels respectively. These results will be useful for the in-depth understanding of the particles deposited on the leaf surface.

https://ift.tt/2vp3Bhz

Nexus between financial development and CO 2 emissions in Saudi Arabia: analyzing the role of globalization

Abstract

This study examines the contribution of financial development to environmental degradation in Saudi Arabia in the period from 1971 to 2016, controlling the model for globalization and electricity consumption. The autoregressive distributive lag (ARDL) and vector error correction methods (VECM) are applied to the long-run and causal relationship, respectively. Empirical results indicate that financial development contributes to CO₂ emissions and degrades environmental quality. The results also show that the role of globalization in environmental degradation is insignificant and that electricity consumption is the main culprit behind the growing CO₂ emissions in Saudi Arabia. In addition, bidirectional causality exists between globalization and CO₂ emissions in the long run, and financial development and CO₂ emissions Granger-cause each other. Insights from the study help policymakers to understand the roles of financial development and globalization in environmental degradation and to comply with global mandate for the reduction of CO₂ emissions.

https://ift.tt/2ng5GrG

Estimating short-term mortality and economic benefit attributable to PM 10 exposure in China based on BenMAP

Abstract

With the rapidly booming economy, China has been suffering from serious particulate matter (PM) pollution in recent years. In order to improve the air quality, Chinese government issued a new China National Ambient Air Quality Standard (No. GB3095-2012) in 2012. In this study, PM₁₀ exposure level was simulated based on the data of 912 newly constructed monitoring sites and Voronoi Neighborhood Averaging (VNA) interpolation method. It is widely accepted that PM₁₀ can cause short-term health effects. We calculated the short-term health benefit due to decreasing PM₁₀ concentration to the levels of China National Ambient Air Quality Standard based on Environmental Benefits Mapping and Analysis Program (BenMAP). Our results indicated that if the daily average concentration of PM₁₀ reduced to the daily Grade II standard (150 μg/m³), the avoided deaths for all cause, cardiovascular disease, and respiratory disease would be 82,000 (95%CI: 49,000–120,000), 56,000 (95%CI: 34,000–78,000), and 16,000 (95%CI: 10,000–22,000) in 2014, respectively. The economic benefits of avoiding deaths due to all cause for rolling back the concentration of PM₁₀ to the level of 50 μg/m³ were estimated to be 240 billion CNY and 16 billion CNY using willingness to pay (WTP) and human capital (HC) methods, respectively, which accounted for 0.38% (95%CI: 0.11–0.64%) and 0.03% (95%CI: 0.02–0.03%) of the total annual gross domestic product (GDP) of China in 2014.

https://ift.tt/2vI5xkO

VideoEndocrinology™ High-Impact Videos

VideoEndocrinology™
The Official Journal of: American Thyroid Association

FREE ACCESS through August 13, 2018
Watch now:

Thyroid Fine-Needle Aspiration and Smearing Techniques
Mitsuyoshi Hirokawa, Ayana Suzuki, Akira Miyauchi

Thyroid Fine Needle Aspiration Smear Preparation
Juan Munoz Pena, Jeffrey Arnold

Personalized Selection Criteria for Radioiodine Administration in Low- and Intermediate-Risk Papillary Thyroid Carcinoma
Paul G. Walfish

Thyroidectomy Teaching Module
Amr Hamour, Adrian Mendez, Jeffrey R. Harris, Vincent L. Biron, Hadi Seikaly, David W.J. Côté

The post VideoEndocrinology™ High-Impact Videos appeared first on American Thyroid Association.

https://ift.tt/2AOmFeo

Anti-oxidative effects of 17 β-estradiol and genistein in human skin fibroblasts and keratinocytes

Publication date: Available online 6 August 2018

Source: Journal of Dermatological Science

Author(s): Paola Savoia, Giulia Raina, Lara Camillo, Serena Farruggio, David Mary, Federica Veronese, Francesca Graziola, Elisa Zavattaro, Rossana Tiberio, Elena Grossini

Abstract

Background

Estrogens and phytoestrogens can hinder the aging process through mechanisms related to estrogen receptors (ERs), guanine nucleotide-binding protein-coupled receptor (GPER30), mitochondria function and nitric oxide (NO) release. Up to date, however, the above issues are a matter of debate.

Objective

To examine the effects elicited by 17 β-estradiol and genistein against peroxidation in human keratinocytes/fibroblasts and evaluate the role played by ERs, GPER30, mitochondria and NO.

Methods

Human fibroblasts/keratinocytes, either subjected to peroxidation or not, were exposed to 17 β-estradiol/genistein in the absence or presence of the NO synthase (NOS) inhibitor, the ERs and GPER30 blockers, fulvestrant and G15, the phosphatidyl-inositol-3-kinase (PI3K-Akt), the p38 mitogen-activated protein (MAP) kinase and the extracellular signal–regulated kinases (ERK) 1/2 inhibitors. Specific kits were used for cell viability, NO, ROS and glutathione (GSH) detection and mitochondrial membrane potential measurement. Western Blot analysis was performed for kinases expression/activation detection.

Results

In physiological and peroxidative conditions, 17 β-estradiol/genistein respectively increased and reduced NO release by fibroblasts/keratinocytes. Moreover, both agents prevented the ROS release and the fall of cell viability and mitochondrial membrane potential, while increasing GSH levels and the proliferation rate. Fulvestrant and G15 counteracted all above responses. Also, the NOS, and the kinases blockers reduced the protection exerted by 17 β-estradiol/genistein on cell viability/mitochondria function. The involvement of PI3K-Akt and p38-MAPK was confirmed by Western blot.

Conclusion

17 β-estradiol/genistein protected fibroblasts/keratinocytes against peroxidation by modulating oxidant/antioxidant system and mitochondria membrane potential, through mechanisms related to ERs and GPER30 and kinases activation.

https://ift.tt/2vnxf6P

Cutaneous permeability barrier function in signal transducer and activator of transcription 6-deficient mice is superior to that in wild-type mice

Publication date: Available online 6 August 2018

Source: Journal of Dermatological Science

Author(s): Wei Zhang, Takashi Sakai, Haruna Matsuda-Hirose, Mizuki Goto, Tomoko Yamate, Yutaka Hatano

ABSTRACT

Background

Th2 cytokines exhibit a variety of inhibitory effects on permeability barrier function via signal transducer and activator of transcription 6 (STAT6). However, the role of STAT6 signaling on the construction and/or homeostasis of permeability barrier function in the physiological state has not been fully assessed.

Objective

We compared permeability barrier function between Stat6-deficient and wild-type C57BL/6 mice at steady state.

Methods and results

Measurement of transepidermal water loss and quantitative penetration assay revealed that permeability barrier function was superior in Stat6-deficient mice. Accordingly, expressions of loricrin, acidic sphingomyelinase (aSMase) and β-glucocerebrosidase (β-GlcCer'ase) in epidermis and ceramide levels in stratum corneum were elevated in STAT6-deficient mice. On the other hands, up-regulations of loricrin, aSMase and β-GlcCer'ase were not observed in 3-dimensionally cultured human keratinocytes transfected with siRNA for STAT6. Meanwhile, number of mast cells in the dermis was decreased in Stat6-deficient mice.

Conclusions

These results suggest that STAT6 signaling negatively affects permeability barrier function in vivo, even in the physiological state. However, the superior permeability barrier function in Stat6-deficient mice may be a secondary effect exerted via cells other than keratinocytes, such as mast cells, since mast cells are known to influence permeability barrier function in vivo. Blockade of STAT6 signaling might be a strategy to augment the permeability barrier function.

https://ift.tt/2ALDVB0

rTMS evidence for a dissociation in short-term memory for spoken words and nonwords

Publication date: Available online 6 August 2018

Source: Cortex

Author(s): Nicola J. Savill, Piers Cornelissen, Anja Pahor, Elizabeth Jefferies

Abstract

Differing patterns of verbal short-term memory (STM) impairment have provided unique insights into the relationship between STM and broader language function. Lexicality effects (i.e., better recall for words than nonwords) are larger in patients with phonological deficits following left temporoparietal lesions, and smaller in patients with semantic impairment and anterior temporal damage, supporting linguistic accounts of STM. However, interpretation of these patient dissociations are complicated by (i) non-focal damage and (ii) confounding factors and secondary impairments. This study addressed these issues by examining the impact of inhibitory transcranial magnetic stimulation (TMS) on auditory-verbal STM performance in healthy individuals. We compared the effects of TMS to left anterior supramarginal gyrus (SMG) and left anterior middle temporal gyrus (ATL) on STM for lists of nonwords and random words. SMG stimulation disrupted nonword recall, in a pattern analogous to that observed in patients, compatible with a role for this site in processing speech sounds without support from long-term lexical-semantic representations. Stimulation of ATL, a semantic site, disrupted the recall of words but not nonwords. A visual pattern memory task indicated that these effects of TMS were restricted to the verbal domain. These data provide convergent evidence for the conclusions of neuropsychological studies that support linguistic accounts of verbal STM.

https://ift.tt/2vHRz2m

Insulin regulates glucagon-like peptide-1 secretion by pancreatic alpha cells

Abstract

Purpose

Proglucagon is expressed in both pancreatic alpha cells and intestinal epithelial L cells and is cleaved into glucagon and glucagon-like peptide-1 (GLP-1) by different prohormone convertases (PCs). Recent studies have shown that α-cells can also secrete GLP-1, which may improve islet function. However, little is known about the factors influencing GLP-1 secretion by α cells. In this study, we investigated whether insulin promotes GLP-1 secretion by α cells, as well as the mechanisms underlying this phenomenon.

Methods

We cultured the alpha-cell line In-R1-G9 in low- or high-glucose medium in the presence or absence of insulin to determine the influence of glucose concentrations on the actions of insulin. We also treated In-R1-G9 cells with insulin for different times and at different doses. Then GLP-1 and glucagon protein expression levels were estimated. Moreover, ERK and phosphatidylinositol-3-kinase/AKT (PI3K/AKT) pathway activity levels and prohormone convertase expression levels were evaluated to elucidate the mechanism underlying the effects of insulin on GLP-1 secretion by α-cells.

Results

Insulin promoted GLP-1 secretion in a time- and dose-dependent manner under high-glucose conditions. Inhibiting the PI3K/AKT pathway with LY294002 and the Ras/mitogen-activated protein kinase (RAS/MAPK) pathway with PD98059 reduced GLP-1 secretion, respectively, in inhibitor-treated cells compared with insulin-treated cells. Moreover, insulin increased prohormone convertase 1/3 expression levels in the corresponding group of IN-R1-G9 cells compared with the control group of cells.

Conclusion

Insulin facilitates GLP-1 secretion by pancreatic alpha cells by inducing PC1/3 expression under high-glucose conditions, a phenomenon that may be associated mainly with PI3K/AKT pathway activation.

https://ift.tt/2AN1Obr

Insulin regulates glucagon-like peptide-1 secretion by pancreatic alpha cells

Abstract

Purpose

Methods

Results

Conclusion

Insulin facilitates GLP-1 secretion by pancreatic alpha cells by inducing PC1/3 expression under high-glucose conditions, a phenomenon that may be associated mainly with PI3K/AKT pathway activation.

https://ift.tt/2AN1Obr

Circulating follicular helper T cells exhibit reduced ICOS expression and impaired function in narcolepsy type 1 patients Running Head: Impaired TFH cell function in narcolepsy

Publication date: Available online 6 August 2018

Source: Journal of Autoimmunity

Author(s): Xuan-Hung Nguyen, Yves Dauvilliers, Clémence Quériault, Corine Perals, Raphaelle Romieu-Mourez, Pierre-Emmanuel Paulet, Raphaël Bernard-Valnet, Nicolas Fazilleau, Roland Liblau

Abstract

Despite genetic and epidemiological evidence strongly supporting an autoimmune basis for narcolepsy type 1, the mechanisms involved have remained largely unknown. Here, we aimed to investigate whether the frequency and function of circulating follicular helper and follicular regulatory T cells are altered in narcolepsy type 1.

Peripheral blood mononuclear cells were collected from 32 patients with narcolepsy type 1, including 11 who developed disease after Pandemrix^® vaccination, and 32 age-, sex-, and HLA-DQB1*06:02-matched healthy individuals. The frequency and phenotype of the different circulating B cell and follicular T cell subsets were examined by flow cytometry. The function of follicular helper T cells was evaluated by assessing the differentiation of naïve and memory B cells in a co-culture assay.

We revealed a notable increase in the frequency of circulating B cells and CD4⁺CXCR5⁺ follicular T cells in narcolepsy patients compared to age-, sex- and HLA-matched healthy controls. However, the inducible T-cell costimulator molecule, ICOS, was selectively down-regulated on follicular T cells from patients. Reduced frequency of activated ICOS⁺and PD1^highblood follicular T cells was also observed in the narcolepsy group. Importantly, follicular T cells isolated from patients with narcolepsy type 1 had a reduced capacity to drive the proliferation/survival and differentiation of memory B cells.

Our results provide novel insights into the potential involvement of T cell-dependent B cell responses in the pathogenesis of narcolepsy type 1 in which down-regulation of ICOS expression on follicular helper T cells correlates with their reduced function. We hypothesize that these changes contribute to regulation of the deleterious autoimmune process after disease onset.

https://ift.tt/2vmKkxa

Cushing’s syndrome: comparison between Cushing’s disease and adrenal Cushing’s

Abstract

Purpose

The most common etiology of Cushing's syndrome (CS) is an ACTH-producing pituitary adenoma (pitCS), reported as 2–3 times more frequent than primary adrenal CS (adrCS). We aimed to analyze and compare features of patients with pitCS and adrCS.

Methods

A retrospective file review of 196 consecutive patients (age 46.8 ± 15.6 years, 76% female) diagnosed with CS in 2000–2017 and followed for 5.2 ± 4.2 years; 109 (55.6%) had pitCS and 76 (38.8%) adrCS. Epidemiologic, clinical and biochemical factors were compared between and within the pitCS and adrCS groups.

Results

The relative proportion of pitCS to adrCS (1.4) was lower than previously reported and gradually decreased during the study years to only 1.2 in 2012–2017. The most common reason for CS screening was weight-gain in the pitCS group (48.6%) and adrenal incidentaloma in the adrCS group (39.5%). The pitCS patients were diagnosed at younger age (42.5 ± 15.1 vs. 51.6 ± 15.1 years, p < 0.001) and had lower prevalence of hypertension (51.4 vs. 74%, p = 0.005). There was no between-group difference in severity of hypercortisoluria. Within the adrCS group, patients diagnosed after detection of an adrenal incidentaloma had milder hypercortisoluria than the remaining patients, presented with smaller adrenal lesions (35.9 ± 16.3 vs. 49.1 ± 33.7 cm, p = 0.04), and received post-adrenalectomy glucocorticoid treatment for shorter periods (13 ± 11.6 vs. 31 ± 40 months, p = 0.04).

Conclusions

The relative proportion of adrCS to pitCS is rising, probably because of an increasing detection of cortisol-secreting adrenal incidentalomas associated with milder hypercortisolism. There is no difference between pitCS and adrCS in the severity of hypercortisoluria, although significant clinical differences were found.

https://ift.tt/2ALWkh5

Cushing’s syndrome: comparison between Cushing’s disease and adrenal Cushing’s

Abstract

Purpose

Methods

Results

Conclusions

https://ift.tt/2ALWkh5

An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter

Abstract

Objectives

Publications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the present study is to reveal whether or not insulin resistance, nodule presence, and nodule stiffness affect arterial stiffness, which is a reliable and valid cardiovascular risk indicator, in individuals with euthyroid nodular goiter using the pulse wave analysis (PWA).

Materials and methods

50 patients with euthyroid nodular goiter and 50 healthy volunteers were included in the study. All participants were examined by B-mode thyroid ultrasound, and the participants in the nodular goiter group were also examined by strain elastography (SE). The strain index of nodules was calculated according to the Rago scoring. Also, fasting plasma glucose (FPG) and insulin levels were measured, and HOMA-IR. Arterial stiffness measurements of the participants were performed using a PWA device which employs a cuff-based oscillometric method from the brachial artery.

Results

PWV was found to be significantly higher in the euthyroid nodular goiter group (p < 0.001). PWV was found to be positively correlated with FPG and waist circumference. Fasting plasma glucose was found to be higher in the group with nodular goiter (p = 0.03). However, no difference was found between the groups in terms of HOMA-IR and insulin level. HOMA-IR was not correlated with thyroid volume, nodule volume, and nodule count. Also, HOMA-IR was not correlated with strain index value and PWA data.

Conclusion

We found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.

https://ift.tt/2M4YeOm

An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter

Abstract

Objectives

Materials and methods

Results

Conclusion

We found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.

https://ift.tt/2M4YeOm

Holistic face perception is impaired in developmental prosopagnosia

Publication date: Available online 6 August 2018

Source: Cortex

Author(s): J. Towler, K. Fisher, M. Eimer

Abstract

Individuals with developmental prosopagnosia (DP) have severe difficulties recognising familiar faces. A current debate is whether these face recognition impairments derive from problems with face perception and in particular whether individuals with DP cannot utilize holistic representations of individual faces. To assess this hypothesis, we recorded event-related potentials (ERPs) during a sequential face identity matching task where successively presented pairs of upright faces were either identical or differed with respect to their internal features, their external features, or both. Participants with DP and age-matched controls reported on each trial whether the face pair was identical or different. To track the activation of cortical visual face memory representations, we measured N250r components over posterior face-selective regions. N250r components to full face repetitions were strongly attenuated for DPs as compared to control participants, indicating impaired face identity matching processes in DP. In the Control group, the N250r to full face repetitions was superadditive (i.e., larger than the sum of the two N250r components to partial repetitions of external or internal features). This demonstrates that holistic face representations were involved in identity matching processes. In the DP group, N250r components to full and partial identity repetitions were strictly additive, indicating that the identity matching of external and internal features operated in an entirely part-based fashion, without any involvement of holistic representations. In line with this conclusion, DPs also made a disproportionate number of errors on partial repetition trials, where they often failed to report a change of internal facial features. This suggests an atypical strategy for encoding external features as cues to identity in DP. These results provide direct electrophysiological and behavioural evidence for qualitative differences in the representation of face identity in the occipital-temporal face processing system in developmental prosopagnosia.

https://ift.tt/2M3uXDz

Information and Learning in Processing of Adjective Inflection

Publication date: Available online 6 August 2018

Source: Cortex

Author(s): Dušica Filipović Đurđević, Petar Milin

Abstract

We investigated the processing of inflected Serbian adjective forms to bring together quantitative linguistic measures from two frameworks – information theory and discrimination learning. From each framework we derived several quantitative descriptions of an inflectional morphological system and fitted two separate regression models to the processing latencies that were elicited by inflected adjectival forms presented in a visual lexical decision task. The model, which was based on lexical distributional and information theory revealed a dynamic interplay of information. The information was sensitive to syntagmatic and paradigmatic dimensions of variation; the paradigmatic information (formalized as respective relative entropies) was also modulated by lemma frequency. The discrimination learning based model revealed an equally complex pattern, involving several learning-based variables. The two models revealed strikingly similar patterns of results, as confirmed by the very high proportion of shared variance in model predictions (85.83%). Our findings add to the body of research demonstrating that complex morphological phenomena can arise as a consequence of the basic principles of discrimination learning. Learning discriminatively about inflectional paradigms and classes, and about their contextual or syntagmatic embedding, sheds light on human language-processing efficiency and on the fascinating complexity of naturally emerged language systems.

https://ift.tt/2LSVhkx

Preliminary randomized controlled trial of antiaging effects of l‐ascorbic acid applied in combination with no‐needle and microneedle mesotherapy

Journal of Cosmetic Dermatology, EarlyView.

https://ift.tt/2M3V655

Use of LC‐MS analysis to elucidate by‐products of niacinamide transformation following in vitro skin permeation studies

International Journal of Cosmetic Science, Volume 0, Issue ja, -Not available-.

https://ift.tt/2Ogt57J

TREatment of ATopic eczema (TREAT) Registry Taskforce: an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema photo‐ and systemic therapy registries

British Journal of Dermatology, EarlyView.

https://ift.tt/2M7rYKq

Melanoma diagnosis during periodic surveillance of patients with multiple atypical naevi

British Journal of Dermatology, EarlyView.

https://ift.tt/2Oft4Rz

Serum homocysteine, folate, and vitamin B12 levels in patients with psoriasis: A systematic review and meta‐analysis

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

https://ift.tt/2M0kny8

Early investigations in drug delivery of onabotulinum toxin A using combined fractional ablative laser with impact ultrasound vs. injections of onabotulinum toxin A for palmar hyperhidrosis: a right–left comparison trial

British Journal of Dermatology, EarlyView.

https://ift.tt/2Ocpsju

Temporal Variation of Staphylococcus aureus clonal complexes in Atopic Dermatitis – a follow up study

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

https://ift.tt/2nesk3J

Infliximab is associated with an increased risk of serious infection in patients with psoriasis in the United Kingdom and Republic of Ireland: results from the British Association of Dermatologists Biologic Interventions Register (BADBIR)

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

https://ift.tt/2OgoUcm

Psoriasis and infection. A clinical practice narrative

Australasian Journal of Dermatology, EarlyView.

https://ift.tt/2OKjQhk

Issue Information

Australasian Journal of Dermatology, Volume 59, Issue 3, Page 163-167, August 2018.

https://ift.tt/2AMqVLu

Cutaneous macroglobulinosis as the initial presentation of Waldenstrom macroglobulinemia in a patient with a history of diffuse large B‐cell lymphoma

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.

https://ift.tt/2OJwrl3

Clinical and histological spectrum of nail psoriasis: a cross sectional study

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.

https://ift.tt/2AJelMR

Assessment of legacy and emerging contaminants in an introduced catfish and implications for the fishery

Abstract

Since introduction into the Chesapeake Bay watershed in the 1970s, blue catfish (Ictalurus furcatus) populations have increased, impacting native species. One strategy suggested to limit their growing numbers is to expand the existing commercial fishery. However, the promotion of human consumption of this large, omnivorous fish may increase exposure to contaminants of concern (COC). However, there are few published data on contaminants in blue catfish. To evaluate this possibility, we measured COC (PCBs, PBDEs, OCs, Hg) in individual fillets and compared levels to established consumption advisory limits. James River (near Richmond, Virginia) and Upper Potomac River (downstream of Washington DC) fish exhibited higher burdens of most COC than those from the lower James and rural Rappahannock rivers. Fish sex and δ¹⁵N values (surrogate for trophic position) did not correlate with COC concentrations. Potomac River fish exhibited greatest δ¹⁵N, perhaps related to local wastewater inputs. Despite differences in human population densities among watersheds, fish mercury (Hg) levels were similar. Most fillets surpassed US EPA advisory limits for unrestricted consumption (> 16 meals/month) for Hg and PCBs. Hg and PCB advisories in the region typically restrict consumption to two 220 g meals/month. Hence, individuals who rely on fish for a large portion of their diet may be exposed to unacceptable Hg and PCB concentrations. COC levels typically increased with fish length; in particular, fish > 550 mm often exceeded unrestricted consumption limits for chlordanes and DDTs. PBDEs, pentachloroanisole, hexachlorobenzene, and mirex levels were generally below established advisories. However, because fish advisories are based on the expected consequences from single contaminants and a single or limited number of toxicological endpoints, consumers face greater risks due to cumulative effects from all coincident COCs, as well as additional exposure pathways, such as other food and air. The additional data on contaminant levels reported here will increase the accuracy of forecasted risks. However, it also illustrates the complexity in communicating the risks from multi-contaminant exposure.

https://ift.tt/2nitWt7

Graves’ Orbitopathy: do not give it for granted

https://ift.tt/2vln5DW

A lung squamous carcinoma patient with ROS1 rearrangement sensitive to crizotinib

Abstract

It is widely known that ROS1 rearrangement mostly occurs in the adenocarcinoma subtype of non-small-cell lung cancer. Patients with squamous cell carcinoma harboring ROS1 rearrangement are extremely rare. This is a case report of a squamous cell carcinoma patient with ROS1 rearrangement. An 84-year-old Chinese woman with a about 6.6 cm mass in the right middle lobe and right pleural effusion, enlarged mediastinal and hilar lymph nodes was diagnosed with stage IIIB lung squamous cell carcinoma harboring ROS1 rearrangement is highly sensitive to crizotinib in the first treatment setting. This is the first time to report lung squamous carcinoma patient with ROS1 rearrangement sensitive to crizotinib. We hope that oncologists will notice this phenomenon and it will help the lung squamous cell carcinoma patient to get longer overall survival time.

https://ift.tt/2KuYMI8

Graves’ Orbitopathy: do not give it for granted

https://ift.tt/2vln5DW

Environmental surveillance for Vibrio cholerae in selected households’ water storage systems in Accra Metropolitan Area (AMA) prior to the 2014 cholera outbreak in Accra, Ghana

Abstract

Cholera is a global public health problem with high endemicity in many developing countries in Africa. In 2014, Ghana experienced its largest epidemic with more than 20,000 cases and 200 deaths; most of it occurred in the Accra Metropolitan Area (AMA). Ghana's disease surveillance system is mainly clinically based and focused on case detection and management. Environmental exploration for the etiological agents is missing from the surveillance strategy. This study therefore assessed the occurrence of toxigenic Vibrio cholerae in water storage systems in selected high risk areas in the AMA area prior to the 2014 outbreak. Three hundred twenty water samples from 80 households' water storage systems were analyzed for toxigenic Vibrio cholerae using the bacterial culture method. Presumptive V. cholerae was isolated from 83.8% of households' water storage systems. The viable cells ranged from 1 to 1400 CFU/100 ml. Vibrio cholerae O1 serotype was isolated from five households in Old Fadama, one household in Shiabu, and one household in Bukom in the month of May and a similar trend was observed for the months of June and July. The presence of Vibro cholerae in the water storage vessels used for drinking confirms the need to consider environmental surveillance for toxigenic Vibro cholerae particularly in high-risk areas to strengthen the existing surveillance system.

https://ift.tt/2OeY8Rp

Effects of nitrification inhibitors on gross N nitrification rate, ammonia oxidizers, and N 2 O production under different temperatures in two pasture soils

Abstract

Australian pasture soil for cattle and sheep industries constitutes the principal land use with considerable N fertilizer consumption, which is one of the causes of local environmental problems. Nitrification plays a key role in regulating soil inorganic N concentration and its environmental diffusion. The effects of different nitrification inhibitors (NIs) on gross N nitrification (n_gross) rate and N₂O production under different temperatures in pasture soils remain unclear. A laboratory incubation experiment was conducted to determine the effect of NIs (dicyandiamide [DCD], 3,4-dimethylpyrazole phosphate [DMPP], and 3-methylpyrazol and 1H-1,2,4-triazol [3MP + TZ]) on N₂O emissions, n_gross and net N nitrification (n_net) rates, and the abundance of ammonia oxidizers, namely, ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB), in two Australian pasture soils incubated at temperatures of 15, 25, and 35 °C. All NIs reduced both n_gross and n_net rates and N₂O production rate from the two pasture soils but to different extents. The inhibitory rates of NIs on n_gross and n_net reached 6.80–63.8 and 5.91–62.3%, respectively, whereas that on N₂O production rate totaled 4.5–41.4% in the tested soils. NIs reduced nitrification and N₂O production by inhibiting the growth of AOB rather than AOA. The inhibitory effects of NIs were temperature-dependent, that is, decreasing with increasing temperature from 15 to 35 °C. In general, DMPP performed better than DCD and 3MP + TZ at 15 and 35 °C, whereas DCD performed more effectively than the other two NIs at 25 °C. Our results suggest that the utilization of NIs will depend on the conditions present, especially soil temperature. Additionally, AOB is the target of inhibition when mitigating nitrification and N₂O emission by applying NIs in pasture soils.

https://ift.tt/2ngNgqY

Quantitative contribution of Cd 2+ adsorption mechanisms by chicken-manure-derived biochars

Abstract

This study investigated the efficiency and mechanisms of Cd²⁺ removal by chicken-manure biochar produced at different temperatures. Adsorption kinetics, isotherms, thermodynamic, and desorption were examined, and the biochars before and after adsorption were analyzed by SEM-EDS, FTIR, Boehm titration, and XRD. Kinetics of adsorption were better described by pseudo-second-order kinetic model than pseudo-first-order kinetic and intraparticle diffusion model under different initial Cd²⁺ concentrations of 20, 50, and 100 mg L⁻¹. Equilibrium adsorption was better modeled by Freundlich and Temkin isotherm equations than Langmuir equation at different temperatures of 25, 35, and 45 °C. Thermodynamic parameters confirmed the spontaneous and endothermic nature of the adsorption of Cd²⁺ at all of temperatures. Moreover, functional group complexation, precipitation, and cation exchange jointly contributed to Cd²⁺ adsorption on the biochars, whose relationship with the properties of biochar were also analyzed. The new precipitate as Cd₅(PO₄)₃OH was found during the adsorption. Complexation and precipitation were predominant mechanisms for all biochars (together accounting for 92.4–98.8%), while cation exchange made a relatively minor contribution to total Cd²⁺ removal (accounting for 1.2–7.6%). The relative distribution of each mechanism on the biochars was determined, which deepen our understanding of the Cd²⁺ adsorption process. These results are useful for future practical applications of biochar to removal heavy metals from water.

https://ift.tt/2M6zuVN

Development of Aggressive Squamous Cell Carcinoma With Perineural Invasion During Ruxolitinib Treatment

No abstract available

https://ift.tt/2vmdexD

Comparison of levetiracetam with phenytoin for the prevention of intravenous busulfan-induced seizures in hematopoietic cell transplantation recipients

Abstract

Purpose

Busulfan is used as a conditioning regimen for hematopoietic stem cell transplantation and is known to cause seizures as a side effect. As various anticonvulsant drugs have been reported, we conducted a retrospective investigation regarding the preventive effects and adverse events associated with different anticonvulsants administered alongside intravenous busulfan (ivBu) in our institution.

Methods

We targeted 104 patients who received ivBu at our institution from May 1, 2010 to April 30, 2017. We investigated the seizure prevention rate and adverse events rate under anticonvulsant prophylaxis.

Results

There were 70 cases (67.3%) of phenytoin administration and 34 cases (32.7%) of levetiracetam administration for anticonvulsant therapy. The seizure prevention rate was 98.6% for phenytoin and 100% for levetiracetam; seizures occurred in one out of 104 patients. There were no significant differences in the seizure prevention rate depending on the type of anticonvulsant. Further, there were no differences in adverse events.

Conclusions

Anticonvulsant prophylaxis is considered necessary for safe conditioning with ivBu. Adverse events associated with the use of levetiracetam are within an acceptable range. Further, levetiracetam is considered useful as a preventive drug against seizures during ivBu administration because it is easy to administer and has ideal pharmacokinetics for supportive care.

https://ift.tt/2AKecc3

Κυριακή 5 Αυγούστου 2018

Comparison of the different retention appliances produced using CAD/CAM and conventional methods and different surface roughening methods

Abstract

The purposes of this study are to conduct an in vitro comparison of the shear bond strength, breakage mode, and wire deformation of three different types of retainers and to compare the subsequent enamel surface changes. Two hundred seventy intact lower incisor teeth were embedded in acrylic blocks in pairs. Dead wire and CAD/CAM-fabricated and fiber-reinforced wires were applied to the teeth roughened with acid and Er:YAG or Er,Cr:YSGG laser. The surface roughness was observed by scanning electron and atomic force microscopy. The samples were analyzed for shear bonds. The dead wire and acid group were found to have the highest bonding strength and the strengths for all groups in which acid was used as an agent were found to be higher than others. Deformation of retainers was most noted in the dead wire-acid group. Among all the groups, the CAD/CAM-fabricated wire group showed the least deformation, with no deformation observed. In this study, it was determined that there is a significant correlation between ARI scores and agents. Consequently, acid etching was found to create more enamel surface roughness than laser groups. It was also seen that the combined use of the acid method and dead soft wire had the highest bond strength, even though it was not statistically significant. It was concluded that CAD/CAM-fabricated wire provides the opportunity for reuse in clinical applications due to its lack of deformation, being more conservative for the patient, and being more advantageous for the clinician in terms of session time, considering the residual adhesive amount left on the enamel surface.

https://ift.tt/2OLIuyc

Ετικέτες

Δευτέρα 6 Αυγούστου 2018

September-2018 Volume 18 Issue 3

Oncostatin M promotes the osteogenic differentiation of mouse MC3T3‑E1osteoblasts through the regulation of monocyte chemotactic protein‑1

Investigation of the role of cullin 4A overexpression in human liver cancer

Activation of the KEAP1‑NRF2‑ARE signaling pathway reduces oxidative stress in Hep2 cells

Aucubin suppresses Titanium particles‑mediated apoptosis of MC3T3‑E1 cells and facilitates osteogenesis by affecting the BMP2/Smads/RunX2 signaling pathway

miR‑200b‑3p inhibits proliferation and induces apoptosis in colorectal cancer by targeting Wnt1

Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis

Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells

Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats

SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway

miR‑185‑5p inhibits F‑actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE

Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing

Comprehensive analysis of gene expression profiles provides insight into the pathogenesis of Crohn's disease

Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis

MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10

Analysis of non‑alcoholic fatty liver disease microRNA expression spectra in rat liver tissues

Parathyroid hormone 1‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway

MiR‑500a‑5p promotes glioblastoma cell proliferation, migration and invasion by targeting chromodomain helicase DNA binding protein 5

Kaempferol inhibits interleukin‑1β stimulated matrix metalloproteinases by suppressing the MAPK‑associated ERK and P38 signaling pathways

Effect of cellular mass on chondrogenic differentiation during embryoid body formation

Candidate genes and microRNAs for glioma pathogenesis and prognosis based on gene expression profiles

Low‑frequency ultrasound and microbubbles combined with simvastatin promote the apoptosis of MCF‑7 cells by affecting the LATS1/YAP/RHAMM pathway

'Psoriasis 1' reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways

ROS‑mediated autophagy through the AMPK signaling pathway protects INS‑1 cells from human islet amyloid polypeptide‑induced cytotoxicity

miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/β-catenin pathway in non-small cell lung cancer

Comparison of target volume and clinical effects of four radiotherapy plans for acute lymphoblastic leukemia prior to hematopoietic stem cell transplantation

Downregulation of microRNA‑21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM‑1 cells

Short‑term use of atorvastatin affects glucose homeostasis and suppresses the expression of LDL receptors in the pancreas of mice

Integrative analysis of promising molecular biomarkers and pathways for coronary artery disease using WGCNA and MetaDE methods

MicroRNA‑155 promotes ox‑LDL‑induced autophagy in human umbilical vein endothelial cells by targeting the PI3K/Akt/mTOR pathway

Alterations in necroptosis during ALDH2‑mediated protection against high glucose‑induced H9c2 cardiac cell injury

Identification of a novel idiopathic congenital nystagmus‑causing missense mutation, p.G296C, in the FRMD7 gene

Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia

Eotaxin‑1 and MCP‑1 serve as circulating indicators in response to power frequency electromagnetic field exposure in mice

Bioinformatics approach reveals the key role of C‑X‑C motif chemokine receptor 2 in endometriosis development

Long non‑coding RNA HR1 participates in the expression of SREBP‑1c through phosphorylation of the PDK1/AKT/FoxO1 pathway

Bioinformatic analysis of microRNA expression in Huntington's disease

miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA

RBP4 regulates trophoblastic cell proliferation and invasion via the PI3K/AKT signaling pathway

Corosolic acid reduces 5‑FU chemoresistance in human gastric cancer cells by activating AMPK

Rapid diagnosis of human adenovirus B, C and E in the respiratory tract using multiplex quantitative polymerase chain reaction

Establishment of a novel non‑alcoholic fatty liver disease model using cholesterol‑fed rabbits with reference to the potential role of endoplasmic reticulum stress

Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines

Luteolin inhibits angiogenesis of the M2‑like TAMs via the downregulation of hypoxia inducible factor‑1α and the STAT3 signalling pathway under hypoxia

Sevoflurane attenuates ventilator‑induced lung injury by regulating c‑PLA2 expression

Astragalin and dihydromyricetin as adjuncts to histidine‑tryptophan‑ketoglutarate cardioplegia enhances protection during cardioplegic arrest

Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functions

MicroRNA‑29a contributes to intracranial aneurysm by regulating the mitochondrial apoptotic pathway

Tanshinone IIA attenuates paraquat‑induced acute lung injury by modulating angiotensin‑converting enzyme 2/angiotensin‑(1‑7) in rats

Expression of transmembrane protein 41A is associated with metastasis via the modulation of E‑cadherin in radically resected gastric cancer

PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway

Spilanthol inhibits TNF‑α‑induced ICAM‑1 expression and pro‑inflammatory responses by inducing heme oxygenase‑1 expression and suppressing pJNK in HaCaT keratinocytes

Associations of CXCL16, miR‑146a and miR‑146b in atherosclerotic apolipoprotein E‑knockout mice

Network‑based gene function inference method to predict optimal gene functions associated with fetal growth restriction

Obtusifolin inhibits high glucose‑induced mitochondrial apoptosis in human umbilical vein endothelial cells

Decreased expression of TROAP suppresses cellular proliferation, migration and invasion in gastric cancer

P2X7 receptor regulates EMMPRIN and MMP‑9 expression through AMPK/MAPK signaling in PMA‑induced macrophages

Differential responses of GC‑1 spermatogonia cells to high and low doses of bisphenol A

Triptolide exhibits antitumor effects by reversing hypermethylation of WIF‑1 in lung cancer cells

Prevalence of hyperuricemia among the Chinese population of the southeast coastal region and association with single nucleotide polymorphisms in urate‑anion exchanger genes: SLC22A12, ABCG2 and SLC2A9

Long non‑coding RNA UCA1 promotes papillary thyroid cancer cell proliferation via miR‑204‑mediated BRD4 activation

Long noncoding RNA UCA1 promotes anaplastic thyroid cancer cell proliferation via miR‑135a‑mediated c‑myc activation

MicroRNA‑130a inhibits the proliferation, migration and invasive ability of hepatocellular carcinoma cells by downregulating Rho‑kinase 2

Dysregulation of CD69 by overexpression of microRNA‑367‑3p associated with post‑myocardial infarction cardiac fibrosis

Association between the HMGB1/TLR4 signaling pathway and the clinicopathological features of ovarian cancer

MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin

MicroRNA‑655 suppresses cell proliferation and invasion in oral squamous cell carcinoma by directly targeting metadherin and regulating the PTEN/AKT pathway

[Corrigendum] Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis

The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)

Anesthetic agent etiomidate induces apoptosis in N2a brain tumor cell line

Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway

Mutation and expression of ABCA12 in keratosis pilaris and nevus comedonicus

Alda‑1, an aldehyde dehydrogenase‑2 agonist, improves long‑term survival in rats with chronic heart failure following myocardial infarction

LncRNA and mRNA interaction study based on transcriptome profiles reveals potential core genes in the pathogenesis of human thoracic aortic dissection

Simvastatin improves cerebrovascular injury caused by ischemia‑reperfusion through NF‑κB‑mediated apoptosis via MyD88/TRIF signaling

Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways

Glassy carbon electrode modified with G‑MoS2‑Nafion acts as an electrochemical biosensor to determine uric acid in human serum

Role of microRNA 146a on the healing of cornea alkali burn treated with mesenchymal stem cells

September-2018
Volume 18
Issue 3

23^nd World Congress on Advances in Oncology & 22^th International Symposium on Molecular Medicine

23 ^rd International Symposium on Molecular Medicine