Scholar : Laryngotracheal reconstruction - νέα αποτελ

Structured care to improve outcomes in primary single stage laryngotracheal reconstruction

PJ Thottam, M Georg, JP Simons, R Kashiwazaski… - International Journal of …, 2018

Purpose To examine single stage laryngotracheal reconstruction (SSLTR) care to
reduce complication and failure rate. Methods Forty-five patients that underwent
primary SSLTR were examined retrospectively. All had pre-operative direct …

Perceptual Evaluation of Voice Disorder in Children Who Have Had Laryngotracheal Reconstruction Surgery and the Relationship Between Clinician Perceptual …

W Cohen, S Lloyd, DM Wynne, RB Townsley - Journal of Voice, 2018

Reliability of the GRBAS tool for perceptual evaluation of paediatric voice disorder is
measured in this study of children with a history of laryngotracheal reconstruction
surgery (LTR). Additionally, the relationship between parent proxy/child self-report of …

 

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Scholar : Laryngomalacia - νέα αποτελέσματα

Novel deletion of 6p21. 31p21. 1 associated with laryngeal cleft, developmental delay, dysmorphic features and vascular anomaly

NR Pillai, D Marafi, SA Monteiro, M Parnes… - European Journal of …, 2018

… She was referred to pulmonology and otolaryngology. Due to recurrent
respiratory infections, a swallow study was performed which showed
aspiration. She had a direct laryngoscopy and bronchoscopy which …

Avoidant/Restrictive Food Intake Disorder: An Adult Case Responding to Cognitive Behavioral Therapy

A Görmez, A Kılıç, İ Kırpınar - Clinical Case Studies, 2018

Avoidant/restrictive food intake disorder (ARFID) is a new diagnostic category in the
Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) which repl...

重症心身障害者における気道狭窄の画像評価

中島務， 山木健市 - 日本気管食道科学会会報, 2018

… Exp Biol Med （Maywood） 241：1316─ 1322, 2016. 14） Thevasagayam M, Rodger
K, Cave D, et al：Prev- alence of laryngomalacia in children presenting with
sleep-disordered breathing. Laryngoscope 120：1662─1666, 2010 …

Comprehensive screening shows that mutations in the known syndromic genes are rare in infants presenting with hyperinsulinaemic hypoglycaemia

TW Laver, MN Wakeling, JHY Hua, JAL Houghton… - Clinical Endocrinology

… At the age of 5 months her weight was 6.06 kg (10th-50th centile), height was 60 cm
(<10th centile) and head circumference was 38.5 cm (<10th centile). She had soft facial
dysmorphism, hypotonia and laryngomalacia with inspiratory stridor …

 

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Scholar : ΑΠΟΚΑΤΑΣΤΑΣΗ - νέα αποτελέσμ

[PDF] Διερευνώντας την επαγγελματική αποκατάσταση των ατόμων με αναπηρία: μια βιβλιογραφική ανασκόπηση

Ο Λάγγας - 2018

Η επαγγελματική αποκατάσταση των ατόμων με αναπηρία, οι ευκαιρίες ένταξης στο
πεδίο εργασίας και τα εμπόδια που παρουσιάζονται αποτελούν πεδία επιστημονικής
έρευνας με αυξανόμενη ερευνητική τάση. Στο πλαίσιο της παρούσας βιβλιογραφικής …

Ενίσχυση Κτιρίων από Οπλισμένο Σκυρόδεμα

Ε Δημητρίου - 2018

… Abstract: Στις μέρες μας, τόσο η ενίσχυση όσο και η επισκευή ή αποκατάσταση
των κατασκευών από οπλισμένο σκυρόδεμα, αποτελούν ένα κύριο θέμα
το οποίο ένας Πολιτικός Μηχανικός πρέπει να γνωρίζει, αφού το φαινόμενο …

[PDF] Ποιότητα και οργανωσιακή κουλτούρα στις υπηρεσίες υγείας

Α Κουλούρη - 2018

Page 1. 0 ΠΟΙΟΤΗΤΑ ΚΑΙ ΟΡΓΑΝΩΣΙΑΚΗ ΚΟΥΛΤΟΥΡΑ ΣΤΙΣ ΥΠΗΡΕΣΙΕΣ
ΥΓΕΙΑΣ Επιβλέπων Καθηγητής: Δρ. Δρόσος Δημήτριος ΚΟΥΛΟΥΡΗ
ΑΓΟΡΙΤΣΑ RN, RMHN, MSc, PhD ΠΕΙΡΑΙΑΣ 2018 Page 2. 1 QUALITY AND …

[PDF] Τεχνικές μη ορατής υδατογράφησης εικόνας

Α Μπίφης - 2018

… Page 25. 25 - Αποκατάσταση: Σκοπóς της αποκατάστασης είναι η διóρθωση των
υποβιβασμών ποιóτητας που μπορεί να έχει δεχθεί μια εικóνα. Δεν απαιτεί γνώση του
θορύβου που εισήγαγε ο αλγóριθμος υδατογράφησης. • Προσθήκη …

 

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Scholar : Undersea "Hyperbaric Medicine" - νέα αποτελέσματα

[PDF] Effect of acetazolamide on morphometry of Wistar rat foetus central nervous system

A Mamidi, B Potturi, R Vijayraghavan, R Paluru - International Journal of Research in …, 2018

… J Trauma. 61: 913-917. Huang, JL., Zhang, YL., Xiao, X., Zhang, JH., Lian, QL., Liu, Y.,
Sun, XJ.2010. Bidirectional influences of acetazolamide on central nervous system oxygen
toxicity of rats. Undersea & Hyperbaric Medicine; Bethesda. 37(5): 271-80 …

Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia

DCJ Ferguson, GR Smerdon, LW Harries, NJF Dodd… - Free Radical Biology and …, 2018

Skip to main content …

[PDF] EFFECTS OF CYCLING EXERCISE AND COLD EXPOSURE ON NEUROMUSCULAR ACTIVATION AND FATIGUE, AND METABOLIC RESPONSES

B Followay - 2018

Page 1. EFFECTS OF CYCLING EXERCISE AND COLD EXPOSURE ON
NEUROMUSCULAR ACTIVATION AND FATIGUE, AND METABOLIC RESPONSES A
dissertation submitted to the Kent State University College of Education …

 

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Scholar : Myringotomy and tubes - νέα αποτελέσματα

Facial nerve palsy in children: A retrospective study of 124 cases

G Psillas, E Antoniades, F Ieridou, J Constantinidis - Journal of Paediatrics and Child …, 2018

… as a complication of AOM; of them, one patient (case 15) had an incidental
finding of neurofibromatosis (NF-1). Three children (cases 2, 4 and 5)
underwent surgery (myringotomy, ventilate tube placement, mastoidectomy) …

 

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Scholar : Cricotracheal resection - νέα αποτελέσματα

声門下狭窄症に対する輪状軟骨鉗除による気管孔拡大形成術の検討

稲木香苗， 大久保啓介， 猪狩雄一， 三橋正継 - 日本気管食道科学会会報, 2018

… 文 献 1 ） 守本倫子：声門下狭窄症．JOHNS 32（4）：517─ 520, 2016. 2 ） 津川二郎，
冨岡雄一郎，西島栄治：初回手術とし て partial cricotracheal resection（PCTR）を行っ
た後天性声門下腔狭窄症の 1 例．日小外会誌 52 （7）：1315─1320, 2016 …

 

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Globus Pallidus Internal Deep-Brain Stimulation in a Patient with Neuroacanthocytosis with Drug-Induced Parkinsonism

Stereotact Funct Neurosurg

https://ift.tt/2MV7LHZ

Safe Stereotactic Biopsy for Basal Ganglia Lesions: Avoiding Injury to the Basal Perforating Arteries

Background: One of the most serious complications of stereotactic biopsy is postoperative symptomatic hemorrhage due to injury to the basal perforating arteries such as the lenticulostriate arteries neighboring the basal ganglia lesions. Objectives: A new target-planning method was proposed to reduce hemorrhagic complications by avoiding injury to the perforating arteries. Methods: Three-dimensional 3-T time-of-flight (3D 3-T TOF) imaging was applied to delineate the basal perforating arteries such as the lenticulostriate arteries. The incidence of postoperative hemorrhage in basal ganglia cases was compared between a new method using 3D 3-T TOF and a conventional target-planning method based on contrast-enhanced T1-weighted magnetic resonance images obtained by 1.5-T scanning. Results: 3D 3-T TOF imaging could delineate the basal perforating arteries sufficiently in target planning. No postoperative hemorrhage occurred with the new method (n = 10), while 6 postoperative hemorrhages occurred with the conventional method (n = 14). The new method significantly reduced the occurrence of postoperative hemorrhages (p = 0.017). Conclusions: 3D 3-T TOF MR imaging with contrast medium administration provides useful information about the perforating arteries and allows safe stereotactic biopsy of basal ganglia lesions.
Stereotact Funct Neurosurg

https://ift.tt/2Ntj6MG

Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia.

Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia.

Case Rep Endocrinol. 2018;2018:7676580

Authors: Yoo JS, Kim J, Kwon HJ, Lim JS

Abstract
Purpose: We report a rare case of severe hypercalcemia that was ultimately diagnosed as primary bone marrow diffuse large B-cell lymphoma (BCL).
Case Report: A 74-year-old male patient visited our hospital complaining of tenderness and swelling of the left knee caused by supracondylar fracture of the left distal femur. His initial blood tests showed a serum calcium level of 13.9 mg/dL, inorganic phosphorus of 4.34 mg/dL, and a serum creatinine level of 1.54 mg/dL. A serum assay of intact parathyroid hormone showed 5.24 pg/mL, and the patient's serum 25(OH)D level was 22.33 ng/mL. To exclude malignancy, we performed imaging studies, including abdomen or chest computed tomography and positron emission tomography-computed tomography; however, no suspicious lesion was found, although the serum PTH-related peptide level was elevated at 4.0 pmol/L. A bone marrow biopsy was performed to identify any hidden hematologic malignancy. As a result, the pathology of bone marrow confirmed the presence of atypical lymphocytes that stained positive for the CD20 marker, which is consistent with BCL involving the bone marrow.
Conclusion: This case highlights the importance of pursuing a thorough workup for rare underlying causes of hypercalcemia when parathyroid-related etiologies can be excluded.

PMID: 30147967 [PubMed]

https://ift.tt/2PdwXXD

Catecholamine-Synthesizing Enzymes in Pheochromocytoma and Extraadrenal Paraganglioma

Abstract

In chromaffin cells, tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase (AADC), dopamine β-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) are mainly involved in catecholamine synthesis. In this study, we evaluated the association between the status of catecholamine-synthesizing enzymes and histopathological features of pheochromocytoma and extraadrenal paraganglioma with special emphasis upon their postoperative clinical behavior. Immunohistochemical evaluation of TH, DBH, AADC, PNMT, Ki 67, and S-100 was performed in 29 pheochromocytoma and 10 extraadrenal paraganglioma and one lymph node harboring metastatic pheochromocytoma. Among these cases, metastasis was subsequently developed in three cases. Urinary normetanephrine (U-NM) levels were significantly higher in clinical metastatic cases than non-metastatic ones. Ki 67 labeling index was significantly higher in both clinical metastatic cases and the Adrenal Gland Scaled Score (PASS) score of ≧ 4 cases than PASS < 4 cases, although this score was originally used in pheochromocytoma. H-score of AADC and DBH were significantly lower in PASS ≧ 4 cases than those with < 4 cases, and in the cases associated with intratumoral necrosis (n = 4), the presence of spindle shaped tumor cells (n = 4), and large nests of cells or diffuse growth (n = 5). Lower status of intratumoral AADC could be related to poor differentiation of tumor cells in both catecholamine production and morphology and could be related to aggressive biological behavior of both pheochromocytoma and extraadrenal paraganglioma.

https://ift.tt/2BQj8wy

Effect of some osmoregulators on photosynthesis, lipid peroxidation, antioxidative capacity, and productivity of barley ( Hordeum vulgare L.) under water deficit stress

Abstract

Water deficit stress is an abiotic stress that causes reductions in growth and yield of many field crops around the world. The present research was aimed to elucidate the mitigating efficiency of exogenous application of select osmoregulators and biostimulants, i.e., potassium dihydrogen phosphate, actosol® (humic acid), Amino more (amino acids), and Compound fertilizer, applied as a spray that reached both foliage and the soil, on growth characteristics, antioxidant capacity, and productivity of barley (Hordeum vulgare L. Giza123) under water deficit stress during two successive growing seasons of field experiments in Egypt. Water deficit resulted in stress as estimated by stress indicators and decreased growth and poor health and development as reflected in statistically significant decreases in chlorophyll a and b and major nutrient (NPK) levels in tissues, stem length, number of leaves, and fresh and dry mass as well as yield components such as spike length, grains per spike, biological yield, grain yield, and 1000-grain weight. As a response to water deficit stress, reactive oxygen species (ROS, i.e., superoxide and hydrogen peroxide) levels increased significantly resulting in lipid peroxidation and decreased membrane integrity and significant increases in antioxidant enzymes such as catalase (CAT), polyphenol oxidase (PPO), and peroxidase (POX). All four treatments alleviated the detrimental impacts of water deficit stress as evidenced by statistically significantly increased photosynthetic pigment concentration, tissue NPK levels, growth, and yield parameters compared to the water deficit-stressed control, while the stress responses were significantly reduced. The osmoregulators used either partially restored the growth and yield of osmotic-stressed barley plants or certain treatments enhanced them. All osmoregulators tested mitigated the adverse impacts of water deficit stress on barley plants, but the highest induction was found when plants were treated with actosol®. The beneficial effects of the osmoregulators tested were the strongest overall in the order actosol® ˃ potassium dihydrogen phosphate ˃ Amino more ˃ Compound fertilizer.

https://ift.tt/2MzarMi

Methylmercury exposure develops atherosclerotic risk factors in the aorta and programmed cell death in the cerebellum: ameliorative action of Celastrus paniculatus ethanolic extract in male Wistar rats

Abstract

Methylmercury (MeHg) is a bioaccumulative global environmental contaminant present in fishes and seafood. MeHg is the methylated form of mercury emitted from diverse anthropogenic and natural sources. MeHg is accumulated in the aquatic environment and eventually reaches human system via food chain by biomagnification. We have reported previously that the neurotoxic effect of MeHg in rat cerebellum is mitigated by the administration of an ayurvedic medicinal plant, Celastrus paniculatus ethanolic extract. The present study has focussed to further explore the mechanism of action of Celastrus paniculatus against MeHg-induced neurotoxicity in the cerebellum. We have also inspected the effect of Celastrus paniculatus (CP) against MeHg-induced atherosclerotic risk factors like alterations in antioxidant levels, aortic lipid profile, and aortic histology by MeHg in the largest vasculature, aorta, which are the initiating factors of cardiovascular diseases. Male Wistar rats were divided as (i) control, (ii) MeHg (5 mg/kg b.w.), (iii) MeHg + CP (200 mg/kg b.w.), and (iv) CP alone (200 mg/kg b.w.). All were given orally for 21 days. In cerebellum Celastrus paniculatus, there were increased mitochondrial electron transport chain (p < 0.05) activity, reduced cytochrome c release (p < 0.05), and caspase 3 mRNA expression (p < 0.05). In the aorta, MeHg-induced oxidative stress, lipid profile changes, and endothelial denudation were ameliorated by Celastrus paniculatus. Hence, we conclude that Celastrus paniculatus protects against MeHg toxicity by inhibiting mitochondrial cytochrome c/caspase 3 apoptotic pathway in the cerebellum and reducing the development of atherosclerotic risk factors in the aorta.

https://ift.tt/2BTAWa9

Toxic metals in Perna viridis mussel and surface seawater in Pasir Gudang coastal area, Malaysia, and its health implications

Abstract

Contamination of toxic metals in P. viridis mussels has been prevalently reported; hence, health risk assessment for consuming this aquaculture product as well as the surrounding surface seawater at its harvesting sites appears relevant. Since Kampung Pasir Puteh, Pasir Gudang is the major harvesting site in Malaysia, and because the last heavy metal assessment was done in 2009, its current status remains unclear. Herein, flame atomic absorption spectrometry and flow injection mercury/hydride system were used to determine the concentrations of Pb, Cd, Cu and total Hg in P. viridis mussels and surface seawater (January–March 2015), respectively. Significantly higher concentrations of these metals were found in P. viridis mussels (p < 0.05) than that of surface seawater samples. The concentrations for Pb (4.27–6.55 μg/g) and Cd (1.55–2.21 μg/g) in P. viridis mussels exceeded the maximum permitted proportion prescribed by the Malaysian law. The concentrations of all metals in surface seawater also violated the Malaysia Marine Water Quality Criteria and Standards. Significant (p < 0.05) and high strength of association (r = 0.787) observed between Pb concentration in P. viridis mussel with the surface seawater indicates its possible application for inferring Pb concentrations in the mussel. Since both the calculated target hazard quotient and hazard index for Pb and Cd exceeded 1, the possible detrimental health impacts on human for consuming P. viridis mussels from this rearing site cannot be ignored. Hence, promoting continuous monitoring programmes and developing efficient toxic metal removal techniques prior to entering the market are required.

https://ift.tt/2POdG0i

Dynamic transport of antibiotics and antibiotic resistance genes under different treatment processes in a typical pharmaceutical wastewater treatment plant

Abstract

The propagation of antibiotic resistance is a challenge for human health worldwide, which has drawn much attention on the reduction of the resistance genes. To understand their occurrence during different treatment processes, in this study, four classes of antibiotics (tetracyclines, sulfonamides, quinolones, and macrolides), eight antibiotic resistance genes (ARGs) (tetB, tetW, sul1, sul2, gyrA, qepA, ermB, and ermF), and two mobile elements (int1 and int2) were investigated in a typical pharmaceutical plant. The total concentrations of antibiotics were detected in the range of 2.6 × 10² to 2.5 × 10³ ng/L in the treatment processes, and the high abundance of ARGs was detected in the biological treatment unit. The dynamic trend analysis showed that antibiotics were partially removed in the anaerobic/aerobic processes, where ARGs were proliferated. The abundance of tetB and gyrA genes was positively correlated with pH and EC (p < 0.05), and the tetW, sul1 and sul2 genes were significantly correlated with TOC, TN, and DO (p < 0.05), indicating the influence of physicochemical properties of the solution on the levels of ARG subtypes. The phylogenetic analysis showed that the tetW clones had high homology with some pathogenic microorganisms, such as Klebsiella pneumonia and Neisseria meningitides, which would threaten human health. Results indicated that the horizontal transfer acted as a major driver in the ARGs evolution.

https://ift.tt/2BTAEjz

Associations of maternal estradiol, cortisol and TGF‐β1 plasma concentrations with thyroid autoantibodies during pregnancy and postpartum

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ofkDe1

Gender Differences in the Association between Melatonin Secretion and Diabetes in Elderly: the HEIJO‐KYO Cohort

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2BQ1U2m

Pre-operative grip force as clinical predictor for weakness after transversal carpal ligament release

Abstract

Background

Temporary or long-lasting loss of grip force after open carpal tunnel release (CTR) in carpal tunnel syndrome (CTS) patients is well known and caused by changes in biomechanical conditions through sectioning of the transverse carpal ligament. We hypothesize to find predicting factors for loss of grip strength.

Methods

We performed dynamometer testing of overall hand grip, tip pinch, and key pinch grip prior, 3 and 6 months after open CTR in 42 CTS subjects. Changes in these three main variables related to pre-operative grip, tip pinch and key pinch forces as well as gender and age were analyzed for significant results (t test, Pearson and Spearman correlations, descriptive statistics; 2-tailed p = .05).

Results

At 3-month post-CTR, overall hand grip force decreased significantly by 11.7% (p = .006), whereas key pinch and tip pinch only decreased by 5.6 and 3.5% (p < .0004). At 6-month post-CTR our subjects showed, compared to pre-operative level, an increase of overall grip force to 94.6% (p = .242) and an improvement of tip pinch to even 107% (p = .169) and key pinch to 102% (p = .675). Further investigation showed that subjects with a strong grip prior to the operation seem to lose more strength 3 and 6 months after operation than subjects with average or low strength results (3 months: Spearman −.522.; 6 months: Spearman −.569, p = .000).

Conclusions

Pre-operative dynamometer assessment can predict loss of grip force and therefore create realistic post-operative expectations. Patients at risk for prolonged weakness after surgery (especially male subjects with high pre-operative grip force), could, instead of early surgical transversal carpal ligament release, profit from enrolling into an extended conservative therapy (immobilization and anti-inflammatory medication). Additionally, these patients undergoing CTR could enroll into an intensive post-operative occupational therapy with focus on grip force training to improve their recovery.

Level of Evidence: Level III, risk / prognostic study

https://ift.tt/2LxAON9

Early‐onset neutropenia after rituximab therapy for bullous pemphigoid

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2oflPhx

Scarring alopecia with follicular papules in a father and his daughter

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Nokyjk

Concentrations and health risks of heavy metals in soils and crops around the Pingle manganese (Mn) mine area in Guangxi Province, China

Abstract

Heavy metal concentrations in agricultural fields and their ecological risks are a source of extensive concern worldwide. A field survey was conducted to investigate the present situation and health risks of heavy metals (Mn, Pb, Zn, Cu, and Cd) and crops (corn, green soybean, sweet potato, persimmon, cassava, and Chinese chestnut) around the Pingle manganese (Mn) mine site in Guangxi Province, China, which was abandoned 20 years ago. The results showed that the ranges of Mn, Pb, Zn, Cu, and Cd were 2706.54–6760.16, 229.37–275.84, 160.39–215.48, 58.11–75.30, and 5.78–6.98 mg kg⁻¹, respectively, which were approximately 15.38–38.41, 11.76–14.15, 2.12–2.85, 2.09–2.71, and 21.64–28.75 times greater than their respective background values. Most of these concentrations exceeded the national standard for soil quality (grade 2) developed by the Ministry of Environmental Protection of China (1995). Contamination assessments based on the single contamination index (P_i), Nemerow multi-factor index (P_com), and potential ecological risk index (RI) showed that the sampled soils were severely polluted with these heavy metals, especially Pb and Cd. Similarly, the crops were enriched with Pb and Cd, with concentrations of 10.22–41.78 and 2.33–5.37 mg kg⁻¹, respectively, which were much higher than the threshold values of the national food standards. Contamination assessments with P_i and P_com also showed that the crops were severely polluted with Pb and Cd. The bioaccumulation factor values for Cd were highest among the heavy metals, with an average mean of 0.66 in these six crops, demonstrating that Cd readily accumulates in these crops. An assessment showed that the health risk for adults living in the mining-impacted areas was significant. Our study strongly recommends that heavy metal contamination in agricultural soils and crops grown around the Pingle Mn mining-affected areas should be treated to mitigate the health risks.

https://ift.tt/2PGKlEV

Statement from NCI Director Dr. Norman E. Sharpless on the Death of Senator John McCain

Senator John McCain, a long-time supporter of cancer research, passed away on August 25.

https://ift.tt/2NpiGqx

The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0669-9309

Background Both vitamin D preparations and high-dose statin therapy were found to reduce thyroid antibody titers. Objective The purpose of this study was to assess whether vitamin D status determines the effect of statin therapy on thyroid autoimmunity. Methods The study population consisted of 39 euthyroid women with Hashimoto's thyroiditis and moderate or moderately high cardiovascular risk divided into two groups: women with vitamin D deficiency or insufficiency (group A; n=19) and women with normal vitamin D status (group B, n=20). All patients received atorvastatin therapy (20–40 mg daily) for the following 6 months. Plasma lipids, circulating levels of thyrotropin, free thyroid hormones, prolactin and 25-hydroxyvitamin D, titers of thyroid peroxidase and thyroglobulin antibodies, as well as Jostel's, the SPINA-GT and the SPINA-GD indices were assessed at the beginning and at the end of the study. Results The study completed all women. At baseline, with the exception of 25-hydroxyvitamin D, there were no significant differences between both study groups in plasma lipids, circulating hormone levels and titers of thyroid peroxidase and thyroglobulin antibodies. Despite improving plasma lipids in both study groups, atorvastatin reduced thyroid antibody titers only in women with normal vitamin D status. Moreover, in this group of patients, atorvastatin increased the SPINA-GT index. Circulating levels of the measured hormones, Jostel's thyrotropin index and the SPINA-GD index remained at a similar level throughout the study. Conclusions The results of the study suggest that the effect of atorvastatin therapy on thyroid autoimmunity depends on vitamin D status.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2wlPOJb

Elevation in Circulating Soluble CD40 Ligand Concentrations in Type 2 Diabetic Retinopathy and Association with its Severity

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0647-6860

Background To investigate the relationship between changes in circulating soluble CD40 ligand (sCD40L) levels and the presence and severity of type 2 diabetic retinopathy (DR). Subjects and methods sCD40L plasma concentrations were measured in 205 type 2 diabetes (T2DM) patients without DR (DWR; n=50) and with DR (n=155), the latter subdivided into non-proliferative diabetic retinopathy [NPDR; n=98 (63.2%)], or proliferative retinopathy [PDR; n=57 (36.8%)] patients. Results Receiver operating characteristic analysis provided good discriminatory power for sCD40L as predictor of DR presence, with high sensitivity and specificity. Categorizing DWR and DR patients into sCD40L quartiles, based on sCD40L concentrations in T2DM without DR, demonstrated statistically significant gradual increase in DR risk with increasing sCD40L levels. sCD40L levels were significantly higher in DR compared to DWR patients. Plasma sCD40L levels differed significantly according to DR severity, and correlated with diabetes duration, dyslipedimea, nephropathy, and presence of DR, but not with gender, age, SBP, DBP, FPG, HbA1c, T2DM medications. Linear regression analysis confirmed the association of increased sCD40L levels with DR, independent of others parameters; mean plasma sCD40L levels differing significantly according to DR severity. Conclusion Plasma sCD40L levels were positively associated with DR. The significant finding here is that sCD40L levels can be predictors of DR severity.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2P9kBQo

Statins and Colorectal Cancer – A Systematic Review

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0668-5692

Objectives Statins act by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase and are an important drug class in the treatment of lipid disorders. They lower cholesterol levels and modulate cardiovascular disease risk in both primary and secondary prevention. In addition, some studies have shown that statins may have an effect on colorectal cancer development and treatment. Our objective is to summarize published studies on the effect of statins on colorectal carcinogenesis. Methods A systematic review of the PubMed and Cochrane databases was performed to identify studies published between April 2010 and April 2018 that investigated the association between statin use and colorectal cancer incidence, mortality, and treatment. Results Overall, 126 articles were identified with our search strategy. Based on the eligibility criteria, 69 studies were excluded from the review process. In vitro and animal studies have shown a potential chemopreventive effect of statins and their efficacy in adjuvant therapy of colorectal cancer. The anticarcinogenic effect on cancer risk in human studies was heterogeneous. Some studies reported better overall and cancer specific survival rates in patients using statins before and during colorectal cancer treatment. Statins also show a potential role in chemoprevention of colorectal cancer in patients with inflammatory bowel disease. Conclusions Accumulating evidence suggests that statins may have a role in colorectal cancer prevention and treatment. Further studies are necessary to define the associations between individual statin characteristics, their doses and colorectal cancer.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2wkfupI

Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients with Prediabetes

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0664-7583

Aim To evaluate the effect of dapagliflozin on insulin secretion and insulin sensitivity in patients with prediabetes. Methods A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 adults diagnosed with prediabetes and without pharmacological treatment. Patients were randomly assigned into two groups of 12 patients each to receive 10 mg of oral dapagliflozin or placebo once a day during 12 weeks. At baseline and at the end of the study, anthropometric and metabolic measurements were evaluated, including the first phase of insulin secretion, total insulin secretion, and insulin sensitivity. Results After dapagliflozin administration, there were significant decreases in body weight (80.8±16.3 vs. 77.8±14.9 kg, p=0.019), body mass index (30.3±3.5 vs. 29.2±3.1 kg/m2, p=0.023), waist circumference (100.6±13.5 vs. 96.2±11.8 cm, p=0.003), fasting glucose (5.9±0.4 vs. 5.1±0.3 mmol/L, p<0.001) and uric acid (334.3±70.8 vs. 262.9±60.7 mmol/L, p=0.032), with a tendency to increase the insulin sensitivity (1.94±0.72 vs. 2.63±1.04, p=0.064). Conclusion Dapagliflozin administration in patients with prediabetes decreased body weight, body mass index, waist circumference, fasting glucose, and uric acid, with a tendency to increase the insulin sensitivity without changes in insulin secretion.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2C1hl8e

``Re-Using the internal mammary artery as recipient artery in cervicofacial reconstruction by fibular flap''

We have read with great interest Decaudaveine's anatomical study entitled "Using the internal mammary artery as recipient artery in cervicofacial reconstruction by fibular flap".1 We congratulate the authors for their interesting and innovative work, opening new perspectives of maxillofacial reconstructive surgery in patients with vessel-depleted neck area. We published last year a quite similar study in Surgical and Radiologic Anatomy.2 This paper was based on a medical thesis defended in our Faculty in 2016.

https://ift.tt/2wgzHMY

Inferior portion of the perpendicular plate of the ethmoid as a suitable grafting material in rhinoplasty and septoplasty procedures

 

https://ift.tt/2BU4KUc

Letter responds to comment on published paper: “Using the internal mammary artery as recipient artery in cervicofacial reconstruction by fibular flap”

We have received the letter of J. Adnot about our study entitled "Using the internal mammary artery as recipient artery inervicofacial reconstruction by fibular flap" 1 and read it with great interest.

https://ift.tt/2wiquDK

One-Stage Treatment for Maxillo-Facial Asymmetry with Orthognathic and Contouring Surgery using virtual surgical planning and 3D-printed surgical templates

Asymmetry is one of the most common maxillo-facial deformities. One-stage treatment for maxillo-facial asymmetry with orthognathic and contouring surgery has been rarely reported. This retrospective study aims to investigate the feasibility of simultaneous orthognathic and facial bone contouring surgery with the help of virtual surgical planning and 3D-printed navigation templates for facial asymmetry.

https://ift.tt/2NoTmB3

Risk factors for developing capsular contracture in women after breast implant surgery: A systematic review of the literature

We thank Dr. Altundag for his interest in our review about risk factors for developing capsular contracture after breast implant surgery.1 Dr. Altundag postulates that adjuvant radiotherapy is also an important risk factor.

https://ift.tt/2wj795z

Annual variation patterns of the effluent water quality from a green roof and the overall impacts of its structure

Abstract

To explore the optimal combination of vegetation type, substrate type, and substrate thickness in a green roof and the interannual variation patterns of the runoff quality, eight green roof units were constructed in Shenzhen, China. Runoff quality of the eight units was monitored for 3 years (24 rainfall events). The rainfall event mean concentrations (EMC) were used to evaluate runoff quality as well as annual pollutant load. An orthogonal L₈(2⁴) experiment was designed to verify the significance of different factors. An optimal level of significant factors was selected to determine the optimal design of green roof. The optimal vegetation was Ophiopogon japonicus. The optimal substrate was modified perlite, while optimal substrate thickness was 200 mm. A three-year interannual variation analysis was performed on the optimal green roof. It was found that the interannual variation of each runoff quality index is different. The concentrations of SS, COD, and NH₄⁺-N in the runoff decreased with years. The concentration of NO₃⁻-N increased over time, while TP remained stable. The concentration of TN had certain volatility with no significant interannual variation. Overall, the runoff quality of the green roof improves over time. The optimal green roof's runoff quality in the third year including 11 rainfall events was monitored. Results showed that the effluent quality from the green roof was lower than that of precipitation. The average concentrations of SS, COD, NH₄⁺-N, TN, and TP decreased respectively by 37.85%, 28.89%, 30.25%, 14.52%, and 12.93%, but NO₃⁻-N increased by 69.91% comparing to the traditional roof.

https://ift.tt/2MUqQKx

Formation of 1,3,8-tribromodibenzo- p -dioxin and 2,4,6,8-tetrabromodibenzofuran in the oxidation of synthetic hydroxylated polybrominated diphenyl ethers by iron and manganese oxides under dry conditions

Abstract

Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are ubiquitous and highly toxic emerging endocrine disruptors found in surface and subsurface soils and clay deposits. Seriously, they could be easily transformed to the more toxic dioxins (PBDD/Fs) in photochemical processes and incineration, but the spontaneous formation of PBDD/Fs has rarely been reported. This study focused on the formation of 1,3,8-tribromodibenzo-p-dioxin (1,3,8-TrBDD) and 2,4,6,8-tetrabromodibenzofuran (2,4,6,8-TeBDF) from 2′-OH-BDE-68 and 2,2′-diOH-BB-80 under the oxidization of iron and manganese oxides (goethite and MnO_x). Approximately 0.09 μmol/kg (2.33%) and 0.17 μmol/kg (4.15%) were transformed to 1,3,8-TrBDD and 2,4,6,8-TeBDF by goethite in 8 days and a higher conversion 0.15 μmol/kg (3.77%) and 0.23 μmol/kg (5.74%) were observed for MnO_x in 4 days. However, the formation of PBDD/Fs, probably proceeding via Smiles rearrangements and bromine elimination processes, was greatly inhibited by the presence of water. Transformation of OH-PBDEs by goethite and MnO_x was accompanied by release of Fe and Mn ions and the possible pathways for the formation of reaction products were proposed. In view of the ubiquity of OH-PBDEs and metal oxides in the environment, oxidation of OH-PBDEs mediated by goethite and MnO_x is likely an abiotic route for the formation of PBDD/Fs.

https://ift.tt/2ocw3zj

Acute effects of air pollution on type II diabetes mellitus hospitalization in Shijiazhuang, China

Abstract

Air pollution has been considered as an important contributor to diabetes development. However, the evidence is fewer in developing countries where air pollution concentrations were much higher. In this study, we conduct a time-series study to investigate the acute adverse effect of six air pollutants on type II diabetes mellitus (T2DM) hospitalization in Shijiazhuang, China. An over-dispersed passion generalized addictive model adjusted for weather conditions, day of the week, and long-term and seasonal trends was used. Finally, a 10-μg/m³ increase of fine particulate matter (PM_2.5), inhalable particulate matter (PM₁₀), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), and carbon monoxide (CO) corresponded to 0.53% (95% confidence interval = 0.22–0.83), 0.32% (95% CI = 0.10–0.55), 0.55% (95% CI = 0.04–1.07), 1.27% (95% CI = 0.33–2.22), and 0.04% (95% CI = 0.02–0.06) increment of T2DM hospitalization, respectively. The effects of PM_2.5, PM₁₀, and CO were robust when adjusted for co-pollutants. The associations appeared to be a little stronger in the cool season than in the warm season. And stronger associations were found in male and elderly (≥ 65 years) than in female and younger people (35–65 years). Our results contribute to the limited data in the scientific literature on acute effects of air pollution on type II diabetes mellitus in developing countries. Main findings: This is the first adverse effect evidence of air pollution on T2DM in Shijiazhuang, a severely polluted city in China. Males were more vulnerable than females in severe pollution.

https://ift.tt/2wi7uFp

Decision between contralateral and ipsilateral DIEP flap harvesting for unilateral breast reconstruction

Abstract

Background

Deep inferior epigastric artery perforator flap (DIEP/DIEAP) procedure is a common method for breast reconstruction after mastectomy. For unilateral breast reconstruction, harvesting of the flap can be done contralaterally or ipsilaterally. The aim of this study is to demonstrate a possible side difference in quality of abdominal skin perfusion from left to right and its causes, which could have implications on our selection of flap harvesting side, operating time, and flap design itself.

Methods

We performed thermographic imaging after induced hypothermia of the abdominal skin in 17 females to evaluate the quality of blood supply to each side of the abdominal wall. Additionally, we examined the diameter of the deep inferior epigastric artery, whether there is a difference in size correlating to the quality of blood supply of each side. Evaluation of our pre-operative thermographic imaging method was performed in four patients which underwent unilateral DIEP flap reconstruction regarding reduction of surgery time and assessment of overall outcome.

Results

Every subject showed a dominant side of perfusion (greater area of perfusion after set time). Furthermore, we discovered a side difference between left and right diameter of the deep inferior epigastric artery in each patient (0.2-mm mean difference; p = 0.0002). The rewarming process of the abdominal skin was faster (16 out of 17 subjects; 94.1%) (greater area of rewarming after set time) on the side with the greater diameter deep inferior epigastric artery. In our DIEP patients using thermographic imaging of the abdominal skin, we only performed perforator dissection on the preferable side. The consequence was a reduction in operating time of 25 minutes compared to careful dissection of both sides. None of our patients showed complications such as wound-healing disorders.

Conclusions

Thermographic assessment of the abdominal skin after hypothermia is easy to conduct and gives reproducible information about different areas of skin perfusion quality. The difference in rewarming speed from left to right is thought to be due to a larger diameter deep inferior epigastric artery, which translates into a superior perfusion, but does not necessarily correlate with the size of the perforators itself. The presented technique offers the potential to improve outcome, especially by lowering perfusion-related complications and reducing operation time by fast dissection of the non-dominant side while carefully dissecting the area of interest with fast thermographic rewarming results, and must therefore be investigated in future studies by measuring objective outcome results.

Level of Evidence: Level III, risk/prognostic

https://ift.tt/2MWBMak

CO 2 bio-fixation and biofuel production in an airlift photobioreactor by an isolated strain of microalgae Coelastrum sp. SM under high CO 2 concentrations

Abstract

Microalgae cultivation is a promising approach to remove ambient CO₂ via photosynthesis process. This paper investigates the impact of high CO₂ concentrations (6, 12, and 16%) on algae growth, CO₂ biofixation, lipid and carbohydrate contents, and nutrient removal of newly isolated microalgae, Coelastrum sp. SM. In addition, the ability of microalgae to produce biodiesel at optimal condition was studied. The microalgae were cultivated in wastewater using an airlift photobioreactor. Under 12% CO₂, the maximum biomass productivity and CO₂ fixation rate were 0.267 g L⁻¹ day⁻¹ and 0.302 g L⁻¹ h⁻¹, respectively. Total Kjeldahl nitrogen (TKN), total phosphorous (TP), nitrate, and sCOD removal efficiency were 84.01, 100, 86.811, and 73.084%, respectively. Under 12% CO₂ and at the same condition for cell growth, the highest lipid and carbohydrate contents were 3 7.91 and 58.45%, respectively. The composition of fatty acids methyl ester (FAME) of the microalga lipid was defined. Based on the obtained results and FAME profile, Coelastrum sp. SM was a suitable feedstock for biodiesel production and also, the organism had a great potential for CO₂ biofixation, which is also more suitable than any other reported strains in other related studies.

https://ift.tt/2Pbz8v2

The Application of Fluorescence Laparoscopy in the Treatment of Adenocarcinoma of the Esophagogastric Junction

Conditions:   Fluorescence Laparoscopy;   Adenocarcinoma of the Esophagogastric Junction
Interventions:   Procedure: fluorescent laparoscopic radical gastrectomy;   Procedure: traditional laparoscopic radical gastrectomy
Sponsor:   Dong Yang
Not yet recruiting

https://ift.tt/2oeE9rf

Lesion Dosimetry With Iodine-124 in Metastatic Thyroid Carcinoma

Conditions:   Thyroid Carcinoma;   Metastatic Thyroid Carcinoma
Interventions:   Device: PET/CT Scan;   Drug: Iodine-124
Sponsor:   Memorial Sloan Kettering Cancer Center
Recruiting

https://ift.tt/2BR2jl9

EBV-TCR-T（YT-E-001） for Patients With EBV-positive Recurrent or Metastatic NPC Patients

Condition:   Nasopharyngeal Carcinoma
Intervention:   Biological: EBV-TCR-T (YT-E001) cells
Sponsors:   Fujian Cancer Hospital;   China Immunotech Co., Ltd.
Not yet recruiting

https://ift.tt/2oe2VaQ

Pain in Parkinson's Disease With Motor Fluctuations.

Condition:   Parkinson Disease
Interventions:   Drug: safinamide metansolfonato (12 weeks);   Drug: rasagilina mesilato (12 weeks)
Sponsors:   Universita di Verona;   Azienda Ospedaliera Universitaria Integrata Verona
Recruiting

https://ift.tt/2BSKbHG

177Lu-PP-F11N in Combination With Sacubitril for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer

Condition:   Thyroid Cancer, Medullary
Interventions:   Drug: 177Lu-PP-F11N;   Drug: Sacuitril
Sponsors:   University Hospital, Basel, Switzerland;   Krebsforschung Schweiz, Bern, Switzerland;   Center for Proton Therapy, Paul Scherrer Institute, Villigen,Switzerland;   University Hospital, Zürich;   University Hospital Freiburg
Not yet recruiting

https://ift.tt/2okImK9

Predictor Analysis of Acute Radiation Oral Mucositis in NPC Patients Treated With IMRT/TOMO Combined Chemotherapy

Condition:   Nasopharyngeal Carcinoma
Intervention:  
Sponsor:   Zhejiang Cancer Hospital
Recruiting

https://ift.tt/2BSK276

Hurley III Hidradenitis Suppurativa Has an Aggressive Disease Course

Dermatology

https://ift.tt/2BQscBv

A Comparison of Vagal Nerve Stimulation and Responsive Neurostimulation for the Treatment of Medically Refractory Complex Partial Epilepsy

Background: Neuromodulatory applications such as vagus nerve stimulation (VNS) and responsive neurostimulation (RNS) are safe and effective strategies for medically intractable epilepsy secondary to complex partial seizures, but researchers have yet to compare their efficacies. Objective: The goal of this study is to compare VNS and RNS efficacy at reducing seizure frequency and complication rates in subjects with medically intractable epilepsy secondary to complex partial seizures. Methods: This is a retrospective chart review of 30 patients with medically intractable complex partial epilepsy, who underwent either VNS or RNS placement at a single institution between June 2012 and January 2016. There was a mean follow-up of 19 months. Seizure frequency reduction and complications were identified. Results: The median seizure frequency reduction was similar for VNS (66%) and RNS (58%). There was no major morbidity or mortality, and the frequency of minor complications was similar between VNS (15%) and RNS (18%). Conclusion: We found that VNS and RNS reduced the median seizure frequency similarly with no difference in morbidity or mortality. Further prospective studies are warranted as VNS and RNS therapy improves over time.
Stereotact Funct Neurosurg

https://ift.tt/2BZ1FSW

Use of Platelet-Rich Plasma in Cicatricial Alopecia

No abstract available

https://ift.tt/2Luzgn5

Utilization Patterns of Fellowship-Trained Mohs Surgeons in the Treatment of Merkel Cell Carcinoma

No abstract available

https://ift.tt/2MVgNES

Atypical Surgical Site Infection After Mohs Micrographic Surgery in an Immunocompetent Individual

No abstract available

https://ift.tt/2LwGneV

Liposomal Bupivacaine: A Review and Applications to Dermatologic Surgery

No abstract available

https://ift.tt/2MVgGsW

Novel Use of Brimonidine 0.33% Gel for Hemostasis in Nail Surgery

No abstract available

https://ift.tt/2wuao9D

Reconstruction of a Large Scalp Defect Devoid of Periosteum

No abstract available

https://ift.tt/2MUxYGL

Association of Postoperative Antibiotics With Surgical Site Infection in Mohs Micrographic Surgery

BACKGROUND Surgical site infection (SSI) is the most frequent complication of Mohs micrographic surgery. Previous studies have identified risk factors for SSI, but it is not known whether antibiotic prophylaxis mitigates this risk. OBJECTIVE To measure the association between antibiotic prophylaxis and SSI in a convenience sample of Mohs cases and to report on the utility of propensity scoring to control for confounding by indication in registry data. METHODS Data were drawn from a pilot quality improvement registry of 816 Mohs cases. The relationship between antibiotic prophylaxis and SSI was assessed with logistic regression modeling using propensity score methods to adjust for confounding. RESULTS One hundred fifty-one cases were prescribed antibiotic prophylaxis (18.5%). Of 467 cases with follow-up, 16 (3.4%) developed SSI. Infection rates were higher in subjects prescribed prophylaxis, but propensity adjustment reduced this effect. Adjusted odds of infection were 1.47-fold higher in subjects prescribed antibiotics and not statistically significant (95% confidence interval 0.29–7.39; p = .64). CONCLUSION Although there was no significant difference in SSI among patients prescribed prophylactic antibiotics, statistical precision was limited by the low incidence of infection. Larger population-based prospective registry studies including propensity adjustment are needed to confirm the benefit of prophylactic antibiotics in high-risk surgical cases. Address correspondence and reprint requests to: Sarah T. Arron, MD, PhD, Department of Dermatology, University of California, 1701 Divisadero Street 3rd Floor, San Francisco, CA 94115, or e-mail: Sarah.Arron@ucsf.edu The authors have indicated no significant interest with commercial supporters. © 2018 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2Lti2qh

Intracytoplasmic eosinophilic inclusion bodies with embryonic folliculosebaceous‐apocrine unit differentiation in syringocystadenoma papilliferum

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2od8Ahi

Overexpressed fibulin‐3 contributes to the pathogenesis of psoriasis by promoting angiogenesis

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2wnqhyw

Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2MQlIqI

Nitrogen plasma skin regeneration for the treatment of mild‐to‐moderate periorbital wrinkles: A prospective, randomized, controlled evaluator‐blinded trial

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2LscHPO

Split‐face comparison study of transcutaneous pneumatic injection therapy with isotonic and hypertonic glucose solutions

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2MUD8m3

Formulation and characterization of a Helianthus annuus ‐ alkyl polyglucoside emulsion cream for topical applications

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2LvPFYq

Reduction of abdominal skin laxity in women postvaginal delivery using the synergistic emission of radiofrequency and targeted pressure energies

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2MU7tBb

Ultrasound evaluation of arterial anastomosis of the forehead

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2LtRJjF

Comparative study of fractional Erbium: YAG laser vs combined therapy with topical steroid as an adjuvant treatment in melasma

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2MRratf

Reply to Hua Liu, HaiCun Shi and PingLei Pan: Coordinate based meta-analyses in a medium sized literature: considerations, limitations and road ahead

We thank Liu and colleagues for their interest in and thoughtful comments on our neuroimaging meta-analysis on insomnia disorder (1). In their commentary, the authors highlight the conceptual and technical diversity among current neuroimaging approaches, including those that were integrated in our recent analysis. We completely concur with their summary on these differences, as indeed different modalities and analysis methods reveal different neurobiological features (2, 3). Therefore, we would like to focus on what we perceive as the critical question arising from this commentary, namely whether the findings obtained by the different methods can be combined in a useful and interpretable way by meta-analyses.

https://ift.tt/2BNwVE2

Brain structural and functional alterations in insomnia disorder: more “homogeneous” research is needed

The authors declare no potential conflicts of interest regarding the authorship and publication.

https://ift.tt/2PCv0VI

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

International Journal of Cosmetic Science, Volume 0, Issue ja, -Not available-.


https://ift.tt/2P7k8OJ

Adjuvant radiotherapy as a risk factor for developing capsular contracture in women after breast implant surgery

I wish to congratulate Bachour and colleagues for their article1 in which they investigated risk factors for developing capsular contracture in women after breast implant surgery in a systematic review of the literature. Longer duration of follow-up, breast reconstructive surgery in patients with a history of breast cancer, subglandular implant placement, postoperative hematoma, and a textured implant surface were found to be a presumptive increased risk factors. However, authors did not take adjuvant radiotherapy into consideration as a risk factor in breast cancer patients.

https://ift.tt/2P8GuiV

Commentary – Consensus research priorities for facial palsy: a Delphi survey of patients, carers, clinicians and researchers

Facial paralysis is a devastating medical condition with approximately 50 cases per 100,000 in the United States.1 The psychological and social distress in individuals with facial paralysis is well documented.2 The overall societal burden and costs are less well understood. With divergent priorities and finite healthcare and research funds, the need for focused research efforts to maximize treatment outcomes is ever more important. This study by Hamlet et al highlights a novel attempt to develop research priorities for facial paralysis using a Delphi survey of a multi-disciplinary group of facial nerve experts, patients and caregivers.

https://ift.tt/2MRwRr9