Scholar : Laryngotracheal reconstruction - νέα αποτελ

Structured care to improve outcomes in primary single stage laryngotracheal reconstruction

PJ Thottam, M Georg, JP Simons, R Kashiwazaski… - International Journal of …, 2018

Purpose To examine single stage laryngotracheal reconstruction (SSLTR) care to
reduce complication and failure rate. Methods Forty-five patients that underwent
primary SSLTR were examined retrospectively. All had pre-operative direct …

Perceptual Evaluation of Voice Disorder in Children Who Have Had Laryngotracheal Reconstruction Surgery and the Relationship Between Clinician Perceptual …

W Cohen, S Lloyd, DM Wynne, RB Townsley - Journal of Voice, 2018

Reliability of the GRBAS tool for perceptual evaluation of paediatric voice disorder is
measured in this study of children with a history of laryngotracheal reconstruction
surgery (LTR). Additionally, the relationship between parent proxy/child self-report of …

 

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Scholar : Laryngomalacia - νέα αποτελέσματα

Novel deletion of 6p21. 31p21. 1 associated with laryngeal cleft, developmental delay, dysmorphic features and vascular anomaly

NR Pillai, D Marafi, SA Monteiro, M Parnes… - European Journal of …, 2018

… She was referred to pulmonology and otolaryngology. Due to recurrent
respiratory infections, a swallow study was performed which showed
aspiration. She had a direct laryngoscopy and bronchoscopy which …

Avoidant/Restrictive Food Intake Disorder: An Adult Case Responding to Cognitive Behavioral Therapy

A Görmez, A Kılıç, İ Kırpınar - Clinical Case Studies, 2018

Avoidant/restrictive food intake disorder (ARFID) is a new diagnostic category in the
Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) which repl...

重症心身障害者における気道狭窄の画像評価

中島務， 山木健市 - 日本気管食道科学会会報, 2018

… Exp Biol Med （Maywood） 241：1316─ 1322, 2016. 14） Thevasagayam M, Rodger
K, Cave D, et al：Prev- alence of laryngomalacia in children presenting with
sleep-disordered breathing. Laryngoscope 120：1662─1666, 2010 …

Comprehensive screening shows that mutations in the known syndromic genes are rare in infants presenting with hyperinsulinaemic hypoglycaemia

TW Laver, MN Wakeling, JHY Hua, JAL Houghton… - Clinical Endocrinology

… At the age of 5 months her weight was 6.06 kg (10th-50th centile), height was 60 cm
(<10th centile) and head circumference was 38.5 cm (<10th centile). She had soft facial
dysmorphism, hypotonia and laryngomalacia with inspiratory stridor …

 

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Scholar : ΑΠΟΚΑΤΑΣΤΑΣΗ - νέα αποτελέσμ

[PDF] Διερευνώντας την επαγγελματική αποκατάσταση των ατόμων με αναπηρία: μια βιβλιογραφική ανασκόπηση

Ο Λάγγας - 2018

Η επαγγελματική αποκατάσταση των ατόμων με αναπηρία, οι ευκαιρίες ένταξης στο
πεδίο εργασίας και τα εμπόδια που παρουσιάζονται αποτελούν πεδία επιστημονικής
έρευνας με αυξανόμενη ερευνητική τάση. Στο πλαίσιο της παρούσας βιβλιογραφικής …

Ενίσχυση Κτιρίων από Οπλισμένο Σκυρόδεμα

Ε Δημητρίου - 2018

… Abstract: Στις μέρες μας, τόσο η ενίσχυση όσο και η επισκευή ή αποκατάσταση
των κατασκευών από οπλισμένο σκυρόδεμα, αποτελούν ένα κύριο θέμα
το οποίο ένας Πολιτικός Μηχανικός πρέπει να γνωρίζει, αφού το φαινόμενο …

[PDF] Ποιότητα και οργανωσιακή κουλτούρα στις υπηρεσίες υγείας

Α Κουλούρη - 2018

Page 1. 0 ΠΟΙΟΤΗΤΑ ΚΑΙ ΟΡΓΑΝΩΣΙΑΚΗ ΚΟΥΛΤΟΥΡΑ ΣΤΙΣ ΥΠΗΡΕΣΙΕΣ
ΥΓΕΙΑΣ Επιβλέπων Καθηγητής: Δρ. Δρόσος Δημήτριος ΚΟΥΛΟΥΡΗ
ΑΓΟΡΙΤΣΑ RN, RMHN, MSc, PhD ΠΕΙΡΑΙΑΣ 2018 Page 2. 1 QUALITY AND …

[PDF] Τεχνικές μη ορατής υδατογράφησης εικόνας

Α Μπίφης - 2018

… Page 25. 25 - Αποκατάσταση: Σκοπóς της αποκατάστασης είναι η διóρθωση των
υποβιβασμών ποιóτητας που μπορεί να έχει δεχθεί μια εικóνα. Δεν απαιτεί γνώση του
θορύβου που εισήγαγε ο αλγóριθμος υδατογράφησης. • Προσθήκη …

 

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Scholar : Undersea "Hyperbaric Medicine" - νέα αποτελέσματα

[PDF] Effect of acetazolamide on morphometry of Wistar rat foetus central nervous system

A Mamidi, B Potturi, R Vijayraghavan, R Paluru - International Journal of Research in …, 2018

… J Trauma. 61: 913-917. Huang, JL., Zhang, YL., Xiao, X., Zhang, JH., Lian, QL., Liu, Y.,
Sun, XJ.2010. Bidirectional influences of acetazolamide on central nervous system oxygen
toxicity of rats. Undersea & Hyperbaric Medicine; Bethesda. 37(5): 271-80 …

Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia

DCJ Ferguson, GR Smerdon, LW Harries, NJF Dodd… - Free Radical Biology and …, 2018

Skip to main content …

[PDF] EFFECTS OF CYCLING EXERCISE AND COLD EXPOSURE ON NEUROMUSCULAR ACTIVATION AND FATIGUE, AND METABOLIC RESPONSES

B Followay - 2018

Page 1. EFFECTS OF CYCLING EXERCISE AND COLD EXPOSURE ON
NEUROMUSCULAR ACTIVATION AND FATIGUE, AND METABOLIC RESPONSES A
dissertation submitted to the Kent State University College of Education …

 

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Scholar : Myringotomy and tubes - νέα αποτελέσματα

Facial nerve palsy in children: A retrospective study of 124 cases

G Psillas, E Antoniades, F Ieridou, J Constantinidis - Journal of Paediatrics and Child …, 2018

… as a complication of AOM; of them, one patient (case 15) had an incidental
finding of neurofibromatosis (NF-1). Three children (cases 2, 4 and 5)
underwent surgery (myringotomy, ventilate tube placement, mastoidectomy) …

 

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Scholar : Cricotracheal resection - νέα αποτελέσματα

声門下狭窄症に対する輪状軟骨鉗除による気管孔拡大形成術の検討

稲木香苗， 大久保啓介， 猪狩雄一， 三橋正継 - 日本気管食道科学会会報, 2018

… 文 献 1 ） 守本倫子：声門下狭窄症．JOHNS 32（4）：517─ 520, 2016. 2 ） 津川二郎，
冨岡雄一郎，西島栄治：初回手術とし て partial cricotracheal resection（PCTR）を行っ
た後天性声門下腔狭窄症の 1 例．日小外会誌 52 （7）：1315─1320, 2016 …

 

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Globus Pallidus Internal Deep-Brain Stimulation in a Patient with Neuroacanthocytosis with Drug-Induced Parkinsonism

Stereotact Funct Neurosurg

https://ift.tt/2MV7LHZ

Safe Stereotactic Biopsy for Basal Ganglia Lesions: Avoiding Injury to the Basal Perforating Arteries

Background: One of the most serious complications of stereotactic biopsy is postoperative symptomatic hemorrhage due to injury to the basal perforating arteries such as the lenticulostriate arteries neighboring the basal ganglia lesions. Objectives: A new target-planning method was proposed to reduce hemorrhagic complications by avoiding injury to the perforating arteries. Methods: Three-dimensional 3-T time-of-flight (3D 3-T TOF) imaging was applied to delineate the basal perforating arteries such as the lenticulostriate arteries. The incidence of postoperative hemorrhage in basal ganglia cases was compared between a new method using 3D 3-T TOF and a conventional target-planning method based on contrast-enhanced T1-weighted magnetic resonance images obtained by 1.5-T scanning. Results: 3D 3-T TOF imaging could delineate the basal perforating arteries sufficiently in target planning. No postoperative hemorrhage occurred with the new method (n = 10), while 6 postoperative hemorrhages occurred with the conventional method (n = 14). The new method significantly reduced the occurrence of postoperative hemorrhages (p = 0.017). Conclusions: 3D 3-T TOF MR imaging with contrast medium administration provides useful information about the perforating arteries and allows safe stereotactic biopsy of basal ganglia lesions.
Stereotact Funct Neurosurg

https://ift.tt/2Ntj6MG

Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia.

Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia.

Case Rep Endocrinol. 2018;2018:7676580

Authors: Yoo JS, Kim J, Kwon HJ, Lim JS

Abstract
Purpose: We report a rare case of severe hypercalcemia that was ultimately diagnosed as primary bone marrow diffuse large B-cell lymphoma (BCL).
Case Report: A 74-year-old male patient visited our hospital complaining of tenderness and swelling of the left knee caused by supracondylar fracture of the left distal femur. His initial blood tests showed a serum calcium level of 13.9 mg/dL, inorganic phosphorus of 4.34 mg/dL, and a serum creatinine level of 1.54 mg/dL. A serum assay of intact parathyroid hormone showed 5.24 pg/mL, and the patient's serum 25(OH)D level was 22.33 ng/mL. To exclude malignancy, we performed imaging studies, including abdomen or chest computed tomography and positron emission tomography-computed tomography; however, no suspicious lesion was found, although the serum PTH-related peptide level was elevated at 4.0 pmol/L. A bone marrow biopsy was performed to identify any hidden hematologic malignancy. As a result, the pathology of bone marrow confirmed the presence of atypical lymphocytes that stained positive for the CD20 marker, which is consistent with BCL involving the bone marrow.
Conclusion: This case highlights the importance of pursuing a thorough workup for rare underlying causes of hypercalcemia when parathyroid-related etiologies can be excluded.

PMID: 30147967 [PubMed]

https://ift.tt/2PdwXXD

Catecholamine-Synthesizing Enzymes in Pheochromocytoma and Extraadrenal Paraganglioma

Abstract

In chromaffin cells, tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase (AADC), dopamine β-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) are mainly involved in catecholamine synthesis. In this study, we evaluated the association between the status of catecholamine-synthesizing enzymes and histopathological features of pheochromocytoma and extraadrenal paraganglioma with special emphasis upon their postoperative clinical behavior. Immunohistochemical evaluation of TH, DBH, AADC, PNMT, Ki 67, and S-100 was performed in 29 pheochromocytoma and 10 extraadrenal paraganglioma and one lymph node harboring metastatic pheochromocytoma. Among these cases, metastasis was subsequently developed in three cases. Urinary normetanephrine (U-NM) levels were significantly higher in clinical metastatic cases than non-metastatic ones. Ki 67 labeling index was significantly higher in both clinical metastatic cases and the Adrenal Gland Scaled Score (PASS) score of ≧ 4 cases than PASS < 4 cases, although this score was originally used in pheochromocytoma. H-score of AADC and DBH were significantly lower in PASS ≧ 4 cases than those with < 4 cases, and in the cases associated with intratumoral necrosis (n = 4), the presence of spindle shaped tumor cells (n = 4), and large nests of cells or diffuse growth (n = 5). Lower status of intratumoral AADC could be related to poor differentiation of tumor cells in both catecholamine production and morphology and could be related to aggressive biological behavior of both pheochromocytoma and extraadrenal paraganglioma.

https://ift.tt/2BQj8wy

Effect of some osmoregulators on photosynthesis, lipid peroxidation, antioxidative capacity, and productivity of barley ( Hordeum vulgare L.) under water deficit stress

Abstract

Water deficit stress is an abiotic stress that causes reductions in growth and yield of many field crops around the world. The present research was aimed to elucidate the mitigating efficiency of exogenous application of select osmoregulators and biostimulants, i.e., potassium dihydrogen phosphate, actosol® (humic acid), Amino more (amino acids), and Compound fertilizer, applied as a spray that reached both foliage and the soil, on growth characteristics, antioxidant capacity, and productivity of barley (Hordeum vulgare L. Giza123) under water deficit stress during two successive growing seasons of field experiments in Egypt. Water deficit resulted in stress as estimated by stress indicators and decreased growth and poor health and development as reflected in statistically significant decreases in chlorophyll a and b and major nutrient (NPK) levels in tissues, stem length, number of leaves, and fresh and dry mass as well as yield components such as spike length, grains per spike, biological yield, grain yield, and 1000-grain weight. As a response to water deficit stress, reactive oxygen species (ROS, i.e., superoxide and hydrogen peroxide) levels increased significantly resulting in lipid peroxidation and decreased membrane integrity and significant increases in antioxidant enzymes such as catalase (CAT), polyphenol oxidase (PPO), and peroxidase (POX). All four treatments alleviated the detrimental impacts of water deficit stress as evidenced by statistically significantly increased photosynthetic pigment concentration, tissue NPK levels, growth, and yield parameters compared to the water deficit-stressed control, while the stress responses were significantly reduced. The osmoregulators used either partially restored the growth and yield of osmotic-stressed barley plants or certain treatments enhanced them. All osmoregulators tested mitigated the adverse impacts of water deficit stress on barley plants, but the highest induction was found when plants were treated with actosol®. The beneficial effects of the osmoregulators tested were the strongest overall in the order actosol® ˃ potassium dihydrogen phosphate ˃ Amino more ˃ Compound fertilizer.

https://ift.tt/2MzarMi

Methylmercury exposure develops atherosclerotic risk factors in the aorta and programmed cell death in the cerebellum: ameliorative action of Celastrus paniculatus ethanolic extract in male Wistar rats

Abstract

Methylmercury (MeHg) is a bioaccumulative global environmental contaminant present in fishes and seafood. MeHg is the methylated form of mercury emitted from diverse anthropogenic and natural sources. MeHg is accumulated in the aquatic environment and eventually reaches human system via food chain by biomagnification. We have reported previously that the neurotoxic effect of MeHg in rat cerebellum is mitigated by the administration of an ayurvedic medicinal plant, Celastrus paniculatus ethanolic extract. The present study has focussed to further explore the mechanism of action of Celastrus paniculatus against MeHg-induced neurotoxicity in the cerebellum. We have also inspected the effect of Celastrus paniculatus (CP) against MeHg-induced atherosclerotic risk factors like alterations in antioxidant levels, aortic lipid profile, and aortic histology by MeHg in the largest vasculature, aorta, which are the initiating factors of cardiovascular diseases. Male Wistar rats were divided as (i) control, (ii) MeHg (5 mg/kg b.w.), (iii) MeHg + CP (200 mg/kg b.w.), and (iv) CP alone (200 mg/kg b.w.). All were given orally for 21 days. In cerebellum Celastrus paniculatus, there were increased mitochondrial electron transport chain (p < 0.05) activity, reduced cytochrome c release (p < 0.05), and caspase 3 mRNA expression (p < 0.05). In the aorta, MeHg-induced oxidative stress, lipid profile changes, and endothelial denudation were ameliorated by Celastrus paniculatus. Hence, we conclude that Celastrus paniculatus protects against MeHg toxicity by inhibiting mitochondrial cytochrome c/caspase 3 apoptotic pathway in the cerebellum and reducing the development of atherosclerotic risk factors in the aorta.

https://ift.tt/2BTAWa9

Toxic metals in Perna viridis mussel and surface seawater in Pasir Gudang coastal area, Malaysia, and its health implications

Abstract

Contamination of toxic metals in P. viridis mussels has been prevalently reported; hence, health risk assessment for consuming this aquaculture product as well as the surrounding surface seawater at its harvesting sites appears relevant. Since Kampung Pasir Puteh, Pasir Gudang is the major harvesting site in Malaysia, and because the last heavy metal assessment was done in 2009, its current status remains unclear. Herein, flame atomic absorption spectrometry and flow injection mercury/hydride system were used to determine the concentrations of Pb, Cd, Cu and total Hg in P. viridis mussels and surface seawater (January–March 2015), respectively. Significantly higher concentrations of these metals were found in P. viridis mussels (p < 0.05) than that of surface seawater samples. The concentrations for Pb (4.27–6.55 μg/g) and Cd (1.55–2.21 μg/g) in P. viridis mussels exceeded the maximum permitted proportion prescribed by the Malaysian law. The concentrations of all metals in surface seawater also violated the Malaysia Marine Water Quality Criteria and Standards. Significant (p < 0.05) and high strength of association (r = 0.787) observed between Pb concentration in P. viridis mussel with the surface seawater indicates its possible application for inferring Pb concentrations in the mussel. Since both the calculated target hazard quotient and hazard index for Pb and Cd exceeded 1, the possible detrimental health impacts on human for consuming P. viridis mussels from this rearing site cannot be ignored. Hence, promoting continuous monitoring programmes and developing efficient toxic metal removal techniques prior to entering the market are required.

https://ift.tt/2POdG0i

Dynamic transport of antibiotics and antibiotic resistance genes under different treatment processes in a typical pharmaceutical wastewater treatment plant

Abstract

The propagation of antibiotic resistance is a challenge for human health worldwide, which has drawn much attention on the reduction of the resistance genes. To understand their occurrence during different treatment processes, in this study, four classes of antibiotics (tetracyclines, sulfonamides, quinolones, and macrolides), eight antibiotic resistance genes (ARGs) (tetB, tetW, sul1, sul2, gyrA, qepA, ermB, and ermF), and two mobile elements (int1 and int2) were investigated in a typical pharmaceutical plant. The total concentrations of antibiotics were detected in the range of 2.6 × 10² to 2.5 × 10³ ng/L in the treatment processes, and the high abundance of ARGs was detected in the biological treatment unit. The dynamic trend analysis showed that antibiotics were partially removed in the anaerobic/aerobic processes, where ARGs were proliferated. The abundance of tetB and gyrA genes was positively correlated with pH and EC (p < 0.05), and the tetW, sul1 and sul2 genes were significantly correlated with TOC, TN, and DO (p < 0.05), indicating the influence of physicochemical properties of the solution on the levels of ARG subtypes. The phylogenetic analysis showed that the tetW clones had high homology with some pathogenic microorganisms, such as Klebsiella pneumonia and Neisseria meningitides, which would threaten human health. Results indicated that the horizontal transfer acted as a major driver in the ARGs evolution.

https://ift.tt/2BTAEjz

Associations of maternal estradiol, cortisol and TGF‐β1 plasma concentrations with thyroid autoantibodies during pregnancy and postpartum

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ofkDe1

Gender Differences in the Association between Melatonin Secretion and Diabetes in Elderly: the HEIJO‐KYO Cohort

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2BQ1U2m

Pre-operative grip force as clinical predictor for weakness after transversal carpal ligament release

Abstract

Background

Temporary or long-lasting loss of grip force after open carpal tunnel release (CTR) in carpal tunnel syndrome (CTS) patients is well known and caused by changes in biomechanical conditions through sectioning of the transverse carpal ligament. We hypothesize to find predicting factors for loss of grip strength.

Methods

We performed dynamometer testing of overall hand grip, tip pinch, and key pinch grip prior, 3 and 6 months after open CTR in 42 CTS subjects. Changes in these three main variables related to pre-operative grip, tip pinch and key pinch forces as well as gender and age were analyzed for significant results (t test, Pearson and Spearman correlations, descriptive statistics; 2-tailed p = .05).

Results

At 3-month post-CTR, overall hand grip force decreased significantly by 11.7% (p = .006), whereas key pinch and tip pinch only decreased by 5.6 and 3.5% (p < .0004). At 6-month post-CTR our subjects showed, compared to pre-operative level, an increase of overall grip force to 94.6% (p = .242) and an improvement of tip pinch to even 107% (p = .169) and key pinch to 102% (p = .675). Further investigation showed that subjects with a strong grip prior to the operation seem to lose more strength 3 and 6 months after operation than subjects with average or low strength results (3 months: Spearman −.522.; 6 months: Spearman −.569, p = .000).

Conclusions

Pre-operative dynamometer assessment can predict loss of grip force and therefore create realistic post-operative expectations. Patients at risk for prolonged weakness after surgery (especially male subjects with high pre-operative grip force), could, instead of early surgical transversal carpal ligament release, profit from enrolling into an extended conservative therapy (immobilization and anti-inflammatory medication). Additionally, these patients undergoing CTR could enroll into an intensive post-operative occupational therapy with focus on grip force training to improve their recovery.

Level of Evidence: Level III, risk / prognostic study

https://ift.tt/2LxAON9

Early‐onset neutropenia after rituximab therapy for bullous pemphigoid

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2oflPhx