Scholar : Obstructive sleep apnea - νέα αποτελέσματα

The aging effect on upper airways collapse of patients with obstructive sleep apnea syndrome

C Vicini, A De Vito, G Iannella, R Gobbi, RM Corso… - European Archives of Oto …, 2018

Purpose To evaluate, using drug-induced sleep endoscopy (DISE), sites of upper
airway obstruction and pattern of collapse in patients over 65 years old affected by
obstructive sleep apnea. To compare sites and pattern of collapse of elderly patients …

Anesthesia for the Pregnant Patient with Obstructive Sleep Apnea

TÖ Seyhan, D Büyük - Obstetric Anesthesia for Co-morbid Conditions, 2018

Obstructive sleep apnea (OSA) is one of the sleep-related breathing disorders. Most
prominent symptoms are snoring, periodic awakening during sleep, and daytime
sleepiness. Over a period of time, OSA leads to increase in vascular resistance and …

Improving Sleep Quality Through Integrated Care

JG Renqvist, AD Bramoweth - Behavioral Medicine and Integrated Care, 2018

… The Negative Effects of Insomnia and Obstructive Sleep Apnea on Health …
bedroom environment to sleep via going to bed and waking at specific times,
getting out of bed when not sleeping and not returning until sleepy, and …

Anesthesia for the Morbidly Obese Pregnant Patient

H Ende, B Kodali - Obstetric Anesthesia for Co-morbid Conditions, 2018

… potentially worsening symptoms, while increased minute ventilation and
side sleeping may be … has been identified as a significant risk factor for airway
obstruction and hypoventilation … If a morbidly obese parturient has a diagnosis …

Effect of gastrectomy on blood pressure in early gastric cancer survivors with hypertension

HJ Kim, EJ Cho, MH Kwak, BW Eom, HM Yoon, SJ Cho… - Supportive Care in Cancer, 2018

… effect of surgical weight reduction has been primarily validated for bariatric
surgery [7]. It may be considered in patients with a body mass index (BMI) ≥
35 kg/m2 who also have one or more comorbidities such as hypertension …

Anesthesia for the Pregnant Diabetic Patient

EA Salviz - Obstetric Anesthesia for Co-morbid Conditions, 2018

… myocardial infarction, decreased heart rate variability, decreased response
to some medications (atropine and propranolol), resting tachycardia,
neurogenic atonic bladder, decreased cough reflex threshold, and increased …

Impact of residual coronary atherosclerosis on transfemoral transcatheter aortic valve replacement

J Li, SM Patel, F Nadeem, P Thakker, S Al‐Kindi… - Catheterization and …, 2018

… was defined by an angiographic luminal stenosis ≥ 50% in vessels ≥ 1.5
mm in diameter.22, 23 Patients who had previously received remote coronary
stenting with minimal or mild in‐stent restenosis were considered to have …

Nutraceuticals and Their Role in Human Health and Disease

A Devi, S Chennakesavulu, C Suresh, ABM Reddy - Functional Food and Human …, 2018

… Obesity is associated with various diseases, particularly cardiovascular
diseases, type 2 diabetes, obstructive sleep apnea, some cancers,
osteoarthritis, and asthma. Scientists have explored the use of nutraceuticals …

Involvement of IL-6 and GSK3β in impaired sensorimotor gating induced by high-fat diet

C Wakabayashi, H Kunugi - Neuroscience Research, 2018

… Glycogen synthase kinase 3. High-fat diet. IL-6. MR16-1. Sensorimotor gating.
Striatum. 1. Introduction. Obesity is a risk factor for many diseases including
type 2 diabetes mellitus, cardiovascular diseases, stroke, and sleep disorders …

The Epidemiology of Medical Diseases and Associated Behavioral Risk Factors

S Lindeman, J Nolan, A Maragakis - Behavioral Medicine and Integrated Care, 2018

… Identified conditions related to obesity range from heart disease and stroke
to diabetes, cancer, sleep apnea (pauses in, or shallow, breathing while
sleeping), and reproductive problems (CDC, 2015b; National Heart … Chronic …

 

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Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ

[PDF] Evaluation of role of propolis in healing of traumatic oral ulcers. An animal experimental study.

A Patel, M Chandak, SA Patel, SS Patel, S Pathak… - … -INDIAN JOURNAL OF …, 2018

… Minor ulcers (size less than 1cm) affect 2 almost 80% population in some
or the other part of their life . The Etiology for oral ulcers include trauma,
infections, vesico-bullous diseases, neoplasia, nutritional deficiencies …

[PDF] Современные возможности лечения метастатического почечно-клеточного рака

БЯ Алексеев, АД Каприн, ГП Колесников… - Онкоурология, 2018

… Гиперхолестеринемия Hypercholesterolemia 17 (33) 6 (12) 8 (16) Снижение массы
тела Weight loss 16 (31) 25 (48) 4 (8) Стоматит Stomatitis 15 (29) 13 (25) 21 (42)
Периферические отеки Peripheral edema 14 (27) 8 (15) 9 (18) …

Nutraceuticals and Their Role in Human Health and Disease

A Devi, S Chennakesavulu, C Suresh, ABM Reddy - Functional Food and Human …, 2018

Nutraceuticals, a growing market since the 1990s, is being used for
prevention and treatment of various diseases. Nutraceuticals are used as
drugs all over the world. While on one hand, researchers...

[PDF] An Evaluation of the Efficacy of Amlexanox and Triamcinolone Topical Paste in the Treatment of Recurrent Aphthous Stomatitis

AH Chalkoo, BA Wani, P Sharma, T Jan

Introduction: Recurrent aphthous stomatitis (RAS) is a common condition of the
mucosa of oral cavity characterized by recurrent attacks of small, round or oval,
painful affecting 5-25% of the general population and rarely involves genital region …

[HTML] CONGENITAL NEUTROPENIA AND PRIMARY IMMUNODEFICIENCY DISEASES

J Spoor, HF Fard, N Rezaei - Critical Reviews in Oncology/Hematology, 2018

Auf die Patientenmotivation kommt's an

E dem Krankheitsverlauf

… Nagelbettentzündungen, Stomatitis, Übelkeit, Fatigue und eben Hautveränderungen
usw … So ließ sich mit intensiver Betreuung eine signifikante Verbesserung hinsichtlich
Schmerz, Stomatitis und anderen Nebenwirkungen erreichen …

[HTML] Search Site

HJ Boyle, JP Droz

… life (QOL) compared with patients receiving mitoxantrone. The main side effects
of docetaxel are asthenia, diarrhea, nail changes, peripheral edema, sensory
neuropathy, and stomatitis. These side effects can affect patients …

[HTML] Search Site

R Knecht

… 31 The most commonly reported grade 3–4 adverse events in the radiotherapy alone
and radiotherapy plus cetuximab groups were skin reaction (21.2 and 35.1%, respectively),
mucositis/stomatitis (51.9 and 55.8%, respectively), dysphagia (29.7 and 26%, respectively …

[PDF] Cytogenetic Effects of Quercus infectoria Gall Methanolic Extract in Albino Male Mice

ME Abdalah, GM Aziz, AH Adʼhiah

… A decoction of galls is generally employed as an astringent gargle, which is suggested
to be very effective for tonsillitis, stomatitis and relaxing the throat, while local application
of boiled galls to the skin cures swelling or inflammation …

Search Site

JJ Nuyttens, PY Bondiau

… Patients under chemotherapy may experience side effects such as reduced resistance
to infections, loss of appetite, altered taste, nausea and vomiting, stomatitis and alopecia.
All these side effects decrease or cease upon discontinuation of treatment …

 

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Scholar : ΑΠΟΚΑΤΑΣΤΑΣΗ - νέα αποτελέσμ

Παρέμβαση για την αλλαγή στάσεων μαθητών νηπιαγωγείου τυπικής ανάπτυξης προς μαθητές με ειδικές ανάγκες

Μ Χατζηαθανασίου - 2018

… Date Issued: 2018. Department: Πρόγραμμα Μεταπτυχιακών Σπουδών Ειδική
Αγωγή, Εκπαίδευση και Αποκατάσταση. Supervisor: Αγαλιώτης, Ιωάννης …
Appears in Collections: ΠΜΣ Ειδική Αγωγή, Εκπαίδευση και Αποκατάσταση …

[PDF] Ενίσχυση δομικών στοιχείων οπλισμένου σκυροδέματος με πρόσθετο εξωτερικό οπλισμό απο χάλυβα ή σύνθετα υλικά

Π ΚΑΡΑΓΙΑΝΝΗ, Α ΤΣΟΥΚΑΛΑ - 2018

… μορφή βλάβης που δεν κρίνεται άμεσα επικίνδυνη (ρηγματώσεις σε μη- φέροντα
στοιχεία, πλάκες κλπ.) χρήζουν επισκευής όχι μόνο για λόγους αισθητικούς
και λειτουργικούς ή για προστασία από περιβαλλοντικές δράσεις αλλά πολλές …

 

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Scholar : ΜΑΣΤΟΕΙΔΙΤΙΣ - νέα αποτελέσμ

[PDF] Cerebral Venous Thrombosis: A Clinical Overview

CA Stack, JW Cole - Ischemic Stroke of Brain, 2018

… Of clinical importance, the anatomical posi- tioning of these lateral sinuses near the
mastoid air cells increases their susceptibility to throm- bosis formation in the setting
of ear infections such as chronic otitis media and mastoiditis [4] …

Eosinophilia and reduced STAT3 signalling affect neutrophil cell death in autosomal‐dominant Hyper‐IgE syndrome

S Farmand, B Kremer, M Häffner, K Pütsep, P Bergman… - European Journal of Immunology

Page 1. Received: 04 19, 2018; Revised: 08 29, 2018; Accepted: 10 11, 2018 This
article has been accepted for publication and undergone full peer review but has
not been through the copyediting, typesetting, pagination and …

 

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Scholar : Decannulation - νέα αποτελέσματα

Planned Concomitant Left and Right Ventricular Assist Device Insertion to Avoid Long-term Biventricular Mechanical Support: Bridge to Right Ventricular Recovery.

M Salna, Y Shudo, JJ Teuteberg, D Banerjee, RV Ha… - The heart surgery forum, 2018

… A standardized RVAD weaning protocol was employed in these 4 patients in preparation
for decannulation … All patients survived to RVAD decannulation and discharge and were
alive at the time of most recent follow-up (range, 528-742 days post-RVAD decannulation) …

 

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Scholar : intitle:laryngeal - new results

Intraoperative Nerve Monitoring System during Esophagectomy to Prevent Recurrent Laryngeal Nerve Palsy

M Yuda, K Nishikawa - Kyobu geka. The Japanese journal of thoracic surgery, 2018

Recurrent laryngeal nerve (RLN) palsy can result in motility disorders of the vocal
cord muscles and/or fatal respiratory complications. Procedures aimed at checking
for intraoperative RLN injuries have not been established. Intraoperative nerve …

 

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Scholar : ΦΩΝΗ - νέα αποτελέσματα

[PDF] Παραγωγή οπτικοακουστικού διαφημιστικού μηνύματος για την προώθηση τηλεπικοινωνιακών υπηρεσιών

Γ ΛΑΤΣΗΣ - 2018

… Οι Μπρού κατά της Philadelphia Phillies στο εκπομπή που μεταδόθηκε
υπό την αληθινό τηλεοπτικό spot(σποτ) απλό σημείο για τη Bulova Watch
Co. δεύτερο χέρι και μια φωνή έλεγ … που επικεντρωνόταν σε ένα ρολόι καθώς …

 

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Correction: Prevalence and Progression Rate of Diabetic Retinopathy in Type 2 Diabetes Patients in Correlation with the Duration of Diabetes

Exp Clin Endocrinol Diabetes 2018; 126: e2-e2
DOI: 10.1055/a-0757-3796

[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2PEz4oh

Cardivascular Risk Profile in Patients with Diabetes and Acromegaly or Cushing’s Disease – Analysis from the DPV Database

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0600-9649

Background Although diabetes is a common complication of acromegaly or Cushing´s disease, there are only few detailed studies with a focus on cardiovascular risk, metabolic control or diabetes therapy. Here, we provide a comprehensive characterization from the longitudinal DPV (Diabetes Patienten Verlaufsdokumentation) registry. Methods Patients from the registry≥18 years of age with diabetes and acromegaly or Cushing´s disease were compared to patients with type 1 diabetes or type 2 diabetes using the statistical software SAS 9.4. Results Patients with diabetes and acromegaly (n=52) or Cushing's disease (n=15) were significantly younger at diabetes onset (median age 50.1 and 45.0 vs. 59.0 years in type 2 diabetes; both p<0.05). Dyslipidemia was common in both diseases (71.0% and 88.9% vs. 71.8% in type 2 diabetes; n.s.), while hypertension was most frequent in acromegaly (56.8% vs. 20.9% in type 1 diabetes, p<0.00001). 36.5% of patients with acromegaly and 46.7% with Cushing´s disease receive insulin, compared to 50.4% with type 2 diabetes. Oral antidiabetic drugs were used in 36.5% of patients with acromegaly and 40% with Cushing´s disease, with a predominance of biguanides and dipeptidyl peptidase-4 inhibitors. HbA1c was well controlled in both groups (median 7.0% and 6.5%; vs. 7.2% in type 2 diabetes). Conclusion Patients with acromegaly are at a high risk for cardiovascular disease, reflected by dyslipidemia and hypertension. A high proportion of patients with diabetes in acromegaly or Cushing´s disease receives insulin. Based on a multicenter register, a sufficient number of patients with rare forms of diabetes can be analyzed.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2P8nMeK

Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions

Abstract

Objectives

Genetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts.

Material and methods

Current study examined polymorphisms of PTCH1 (rs357564) and PTCH1 insertion (IVS1-83), GLI1 (rs2228224, rs2228226), SMO (rs2228617), and VDR (rs2228570, rs731236, rs7975232). A case-control study was conducted on 41 keratocyst cases, 43 radicular cyst cases, and control group of 93 healthy individuals without cystic lesions, radiographically confirmed. Single-nucleotide polymorphisms were assessed by real-time and TaqMan SNP genotyping assays, while PTCH1 insertion 18 bp IVS1-83 polymorphism was determined by PCR.

Results

The difference in genotype distribution between keratocyst cases and control group was observed for PTCH1 IVS1-83 and GLI1 rs2228224 polymorphism (p = 0.022, p = 0.030, respectively). Homozygous mutant GG genotype within GLI1 rs2228224 is associated with increased susceptibility for odontogenous keratocysts, with adjusted odds ratio of 4.098 (confidence interval of 1.482–11.328, p = 0.007).

Conclusion

GLI1 rs2228224 and PTCH1 polymorphisms could predispose to odontogenic keratocysts.

Clinical relevance

Variants in hedgehog signaling pathway genes, such as GLI1 and PTCH1, and vitamin D receptor gene, might be considered as molecular risk factors in odontogenic cystic lesions and potential targets for novel therapeutic approaches.

https://ift.tt/2yLuKfF

Dosimetric and volumetric effects in clinical target volume and organs at risk during postprostatectomy radiotherapy

Abstract

Purpose

To assess the reproducibility of the dose–volume distribution of the initial simulation CT, generated using volumetric modulated arc therapy (VMAT) planning, during the radiotherapy of the prostatic bed based on weekly cone beam CTs (CBCT).

Methods

Twenty-three patients, after radical prostatectomy were treated with adjuvant or salvage radiotherapy between July and December 2016 and considered for this evaluation. Weekly CBCT scans (n = 138) were imported into the treatment planning system, and the clinical tumor volume (CTV), the rectum and the bladder were contoured. The initially calculated dose distribution and the dose–volume histograms generated from weekly CBCTs were compared. The prostatic fossa dose coverage was assessed by the proportion of the CTV fully encompassed by the 95% and 98% isodose lines. Rectal and bladder volumes receiving 50, 60 and 65 Gy during the treatment were compared to the initial plan, with statistical significance determined using the one-sample t‑test.

Results

Marked variations in the total organ volume of the rectum and the bladder were observed. The correlation between rectum volume and V₅₀ was not significant (p = 0.487), while the bladder volume and V₅₀ demonstrated a significant correlation. There was no correlation between urinary bladder volume and CTV. The change in rectal volume correlated significantly with CTV. The dose coverage (D_98% and D_95%) to the prostatic bed could be achieved for all patients due to the ventral shift in the volume differences of the rectum.

Conclusion

Weekly CBCTs can be considered as adequate verification tools to assess the interfractional variability of the CTV and organs at risk. The proven volume changes in the urinary bladder and the rectum do not compromise the final delivered dose in the CTV.

https://ift.tt/2PzyGqW

Open-Label, Multicenter, Phase Ⅱ Study of Docetaxel and Cisplatin Combined With Nimotuzumab As First-Line Treatment in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma

Condition:   Over Survival
Intervention:   Drug: Docetaxel and Cisplatin and Nimotuzumab
Sponsor:   Sun Yat-sen University
Not yet recruiting

https://ift.tt/2yqWy9H

Phase II Study of Perioperative Immunotherapy in Patients With Advanced Non-Virally Associated Squamous Cell Carcinoma

Conditions:   Cancer;   Carcinoma;   Squamous Cell Carcinoma;   Head and Neck Cancer
Interventions:   Biological: Atezolizumab;   Biological: Emactuzumab
Sponsors:   University of California, San Francisco;   Genentech, Inc.
Not yet recruiting

https://ift.tt/2yFYSsK

Effectiveness of Antiemetic Regimens for Highly Emetogenic Chemotherapy‐Induced Nausea and Vomiting: A Systematic Review and Network Meta‐Analysis

AbstractBackground.It is important to control chemotherapy‐induced nausea and vomiting (CINV) to maintain dose intensity and patients' quality of life. The National Comprehensive Cancer Network guidelines suggest combination therapy of antiemetic agents. The growing number of antiemetic regimens, and in particular the growing use of regimens containing antagonists to the Nk‐1 receptor (NK1RAs) and the antipsychotic drug olanzapine (OLZ), call for the re‐evaluation of the optimal regimen for CINV. This study assessed the efficacy and safety of antiemetic regimens for highly emetogenic chemotherapy, using Bayesian network meta‐analysis.Methods.Randomized trials that compared different antiemetic regimens were included. We strictly followed Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines. The main outcomes were the odds ratio (OR) for overall complete response (absence of vomiting). We conducted network meta‐analysis within a Bayesian model to combine the direct and indirect evidence. Safety was assessed from the trial description. All statistical tests were two‐sided.Results.We systematically reviewed 27 randomized control trials (13,356 participants), which compared 12 different antiemetic regimens: serotonin‐3 receptor antagonist (5HT3), 5HT3 + dexamethasone (Dex), palonosetron (PAL), PAL + Dex, PAL at 0.75 mg (PAL0.75), PAL0.75 + Dex, NK1RA + 5HT3 + Dex, NK1RA + PAL + Dex, an oral combination of netupitant and palonosetron (NEPA) + Dex, OLZ + 5HT3 + Dex, OLZ + PAL + Dex, and OLZ + NK1RA + 5HT3 + Dex. An NK1RA + 5HT3 + Dex regimen and an NK1RA + palonosetron + Dex regimen gave a higher complete response (CR) rate than the reference regimen, 5HT3 + Dex (OR, 1.75; 95% credibility interval [95% CrI], 1.56–1.97, and OR, 2.25; 95% CrI, 1.66–3.03, respectively). A regimen containing NEPA was more effective in producing CR than conventional regimens without NEPA or olanzapine. Further analysis, based on the surface under the cumulative ranking probability curve, indicated that olanzapine‐containing regimens were the most effective in producing CR.Conclusion.Our meta‐analysis supports the conclusion that olanzapine‐containing regimens are the most effective for CINV of highly emetogenic chemotherapy. We confirmed that NK1RA + PAL + Dex is the most effective of conventional regimens. Substituting olanzapine for an Nk‐1 receptor antagonist may offer a less costly and more effective alternative for patients.Implications for Practice.Nausea and vomiting during chemotherapy often pose difficulties for patients and doctors, making it hard to continue the proper therapy and to maintain the quality of life. This article gives insights into the optimal choice of medicine to treat nausea during chemotherapy. The findings reported here provide readers with a robust efficacy ranking of antinausea medicine, which can be used as a reference for the best possible treatment. Furthermore, the 70% less costly drug, olanzapine, is suggested to be equally effective to aprepitant in reducing nausea and vomiting. The possibility of offering a cost‐effective treatment to a wider range of the population is discussed.

https://ift.tt/2J2MYhw

Transcriptional Responses of Streptococcus gordonii and Fusobacterium nucleatum to Coaggregation

Molecular Oral Microbiology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2QQZYtc

Patient reported outcome measures for soft tissue facial reconstruction: a systematic review and evaluation of the quality of their measurement properties

Background: A patient's health-related quality of life (HRQoL) can be significantly impacted by facial scarring and disfigurement. Facial soft tissue reconstruction should aim to improve HRQoL, with outcomes measured from the patient's perspective using patient-reported outcome measures (PROMs). This systematic review identifies PROMs for soft tissue facial reconstruction and appraises their methodological and psychometric properties using up-to-date methods. Methods: A systematic search of MEDLINE, EMBASE, PsychINFO and Cochrane was performed in line with the PRISMA guidelines. Identified PROMs were assessed using the updated COnsensus-based Standards for the Selection of Health Measurement INstruments (COSMIN) checklist. Psychometric properties were also assessed and a modified GRADE analysis was performed to aid in recommendations for future PROM use. Results: Thirty-four studies covering 9 PROMs were included. Methodological quality and psychometric evidence was variable. FACE-Q, Skin Cancer Index (SCI), Patient Outcome of Surgery – Head/Neck (POS-Head/Neck) and the Derriford Appearance Scale 59/24 all demonstrated high enough evidence to be recommended as having potential for inclusion in future studies. Conclusion: This is the first systematic review to identify and critically appraise PROMs for soft tissue facial reconstruction using internationally accepted criteria. Four PROMs were deemed to have adequate levels of methodological and psychometric evidence, although further studies should be conducted before their routine use in patients undergoing facial reconstruction. Through the use of psychometrically well-validated PROMs it is hoped that patients' concerns can be truly appreciated, level of care improved, and the quality of reconstructive options offered progressed. Meetings: This work has not yet been presented at any meetings. Acknowledgements: We would like to acknowledge the help of Anne Powell, retired librarian at Abertawe Bro Morgannwg University Health Board. Conflicts of Interest and Funding: None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript. This work has received no specific funding. Mr Thomas Dobbs is funded by the Welsh Clinical Academic Training Fellowship. Author role: TD, HH and ISW developed the idea for this systematic review. TD, JG, AT, BP performed the literature review and data extraction. TD and SH assessed all included papers according to the methodology. TD produced the first draft of the manuscript and all authors were then involved in editing to reach the final, submitted version. Corresponding Author: Mr Thomas Dobbs, The Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea. SA6 6NL, e: tomdobbs@doctors.org.uk ©2018American Society of Plastic Surgeons

https://ift.tt/2Cnw9fN

Dysexecutive disorders and their diagnosis: a position paper

Publication date: Available online 17 October 2018

Source: Cortex

Author(s): Olivier Godefroy, Olivier Martinaud, Pauline Narme, Pierre-Alain Joseph, Chrystèle Mosca, Eugénie Lhommée, Thierry Meulemans, Virginie Czernecki, Céline Bertola, Pierre Labauge, Marc Verny, Anne Bellmann, Philippe Azouvi, Claire Bindschaedler, Eric Bretault, Claire Boutoleau-Bretonniere, Philippe Robert, Hermine Lenoir, Marianne Krier, Martine Roussel

Abstract

Although executive function disorders are among the most prevalent cognitive impairments a consensus on diagnostic criteria has yet to be reached. With a view to harmonizing these criteria, the present position paper (i) focuses on the main dysexecutive disorders, (ii) examines recent approaches in both the behavioral and cognitive domains, (iii) defines diagnostic boundaries for frontal syndrome, (iv) reports on the frequency and profile of the executive function disorders observed in the main brain diseases, and (v) proposes an operationalization of diagnostic criteria. Future work must define the executive processes involved in human adaptive behavior, characterize their impairment in brain diseases, and improve the management of these conditions (including remediation strategies and rehabilitation).

https://ift.tt/2RWkSZ5

A Touching Sight:EEG/ERP Correlates for the Vicarious Processing of Affectionate Touch

Publication date: Available online 16 October 2018

Source: Cortex

Author(s): Annett Schirmer, Francis McGlone

Abstract

Observers can simulate aspects of other people's tactile experiences. We asked whether they do so when faced with full-body social interactions, whether emerging representations go beyond basic sensorimotor mirroring, and whether they depend on processing goals and inclinations. In an EEG/ERP study, we presented line-drawn, dyadic interactions with and without affectionate touch. In an explicit and an implicit task, participants categorized images into touch vs no-touch and same vs opposite sex interactions, respectively. Modulations of central Rolandic rhythms implied that affectionate touch displays engaged sensorimotor mechanisms. Additionally, the late positive potential (LPP) being larger for images with as compared to without touch pointed to an involvement of higher order socio-affective mechanisms. Task and sex modulated touch perception. Sensorimotor responding, indexed by Rolandic rhythms, was fairly independent of the task but appeared less effortful in women than in men. Touch induced socio-affective responding, indexed by the LPP, declined from explicit to implicit processing in women and disappeared in men. In sum, this study provides first evidence that vicarious touch from full-body social interactions entails shared sensorimotor as well as socio-affective experiences. Yet, mental representations of touch at a socio-affective level are more likely when touch is goal relevant and observers are female. Together, these results outline the conditions under which touch in visual media may be usefully employed to socially engage observers.

https://ift.tt/2Erjtan

How the visual brain detects emotional changes in facial expressions: Evidence from driven and intrinsic brain oscillations

Publication date: Available online 16 October 2018

Source: Cortex

Author(s): Rafaela R. Campagnoli, Matthias J. Wieser, L. Forest Gruss, Lisa M. McTeague, Maeve R. Boylan, Andreas Keil

Abstract

The processing of facial expressions is often studied using static pictorial cues. Recent work, however, suggests that viewing changing expressions more robustly evokes physiological responses. Here, we examined the sensitivity of steady-state visual evoked potentials and intrinsic oscillatory brain activity to transient emotional changes in facial expressions. Twenty-two participants viewed sequences of grayscale faces periodically turned on and off at a rate of 17.5 Hz, to evoke flicker steady-state visual evoked potentials (ssVEPs) in visual cortex. Each sequence began with a neutral face (flickering for 2290 ms), immediately followed by a face from the same actor (also flickering for 2290 ms) with one of four expressions (happy, angry, fearful, or another neutral expression), followed by the initially presented neutral face (flickering for 1140 ms). The amplitude of the ssVEP and the power of intrinsic brain oscillations were analyzed, comparing the four expression-change conditions. We found a transient perturbation (reduction) of the ssVEP that was more pronounced after the neutral-to-angry change compared to the other conditions, at right posterior sensors. Induced alpha-band (8-13 Hz) power was reduced compared to baseline after each change. This reduction showed a central-occipital topography and was strongest in the subtlest and rarest neutral-to-neutral condition. Thus, the ssVEP indexed involvement of face-sensitive cortical areas in decoding affective expressions, whereas mid-occipital alpha power reduction reflected condition frequency rather than expression-specific processing, consistent with the role of alpha power changes in selective attention.

https://ift.tt/2RU06t7

The profiling of axial spondyloarthritis patient candidate to a biologic therapy: Consensus from a Delphi-panel of Italian experts

Publication date: Available online 16 October 2018

Source: Autoimmunity Reviews

Author(s): Ennio Giulio Favalli, Andrea Becciolini, Roberto Caporali, Monica Todoerti, Florenzo Iannone, Liliana Dinoia, Marco Sebastiani, Amelia Spinella, Elisa Gremese, Francesco Cianci, Fabiola Atzeni, Francesca Bandinelli, Gianfranco Ferraccioli, Giovanni Lapadula, GISEA Study Group

Abstract

Objective

The project aimed to collect expert consensus statements for the profiling of patients with axial spondyloarthritis (axSpA) candidate to biologic agents (bDMARDs) treatment, in order to better define the drivers for the best treatment choice.

Methods

The 6 more interesting topics about axSpA patient profiling were identified by the project steering committee and a panel of axSpA Italian experts. A systematic literature review (SLR) was performed for each of the selected topics according to the PICO format. Two rounds of a modified Delphi process were conducted. In the 1st round, the steering committee evaluated the results of the SLR in order to formulate statements for each topic. In the 2nd round, the experts panel discussed, rephrased when needed, and voted the level of agreement (on a 5-point Likert-type scale) for each statement. Consensus was defined as ≥66% agreement.

Results

The topics selected for the analysis were the differential efficacy of available bDMARDs on enthesitis/dactylitis, uveitis, radiographic progression and cardiovascular involvement, and the clinical response in non radiographic-axSpA and in patients receiving a second-line bDMARD. The Delphi rounds formulated 19 statements, all reaching the defined level of consensus in a second round including 25 rheumatologists highly skilled in the management of axSpA.

Conclusion

Identified consensus statements can help clinicians to apply to routine-care settings the results from clinical studies and international recommendations, providing a guide for individualization of treatment strategy in axSpA patients.

https://ift.tt/2pZzDOd

Defining the Molecular Genetics of Dermoscopic Naevus Patterns

Melanocytic naevi are common melanocytic proliferations that may simulate the appearance of cutaneous melanoma. Naevi commonly harbour somatic mutations implicated in melanomagenesis but in most cases lack the necessary genomic alterations required for melanoma development. While the mitogen-activated protein kinase pathway and ultraviolet radiation strongly contribute to naevogenesis, the somatic mutational landscape of dermoscopic naevus subsets distinguishes some of the molecular hallmarks of naevi in relation to melanoma. We herein discuss the classification of naevi and theories of naevogenesis and review the current literature on the somatic alterations in naevi and melanoma. This review focusses on the clinical-dermoscopic-pathological and genomic correlation of naevi that shapes the current understanding of naevi.
Dermatology

https://ift.tt/2NKNXUg

Gut microbiota translocation promotes autoimmune cholangitis

Publication date: Available online 17 October 2018

Source: Journal of Autoimmunity

Author(s): Hong-Di Ma, Zhi-Bin Zhao, Wen-Tao Ma, Qing-Zhi Liu, Cai-Yue Gao, Liang Li, Jinjun Wang, Koichi Tsuneyama, Bin Liu, Weici Zhang, Yongjian Zhou, M. Eric Gershwin, Zhe-Xiong Lian

Abstract

Gut microbiota and bacterial translocation have been implicated as significant contributors to mucosal immune responses and tolerance; alteration of microbial molecules, termed pathogen-associated molecular patterns (PAMP) and bacterial translocation are associated with immune pathology. However, the mechanisms by which dysregulated gut microbiota promotes autoimmunity is unclear. We have taken advantage of a well-characterized murine model of primary biliary cholangitis, dnTGFβRII mice, and an additional unique construct, toll-like receptor 2 (TLR2)-deficient dnTGFβRII mice coined dnTGFβRIITLR2^−/− mice to investigate the influences of gut microbiota on autoimmune cholangitis. Firstly, we report that dnTGFβRII mice manifest altered composition of gut microbiota and that alteration of this gut microbiota by administration of antibiotics significantly alleviates T-cell-mediated infiltration and bile duct damage. Second, toll-like receptor 2 (TLR2)-deficient dnTGFβRII mice demonstrate significant exacerbation of autoimmune cholangitis when their epithelial barrier integrity was disrupted. Further, TLR2-deficiency mediates downregulated expression of tight junction-associated protein ZO-1 leading to increased gut permeability and bacterial translocation from gut to liver; use of antibiotics reduces microbiota translocation to liver and also decreases biliary pathology. In conclusion, our data demonstrates the important role of gut microbiota and bacterial translocation in the pathogenesis of murine autoimmune cholangitis.

https://ift.tt/2NQuiSY

Editorial Board and Contents

Publication date: November 2018

Source: Trends in Endocrinology & Metabolism, Volume 29, Issue 11

Author(s):

https://ift.tt/2RUtZtm

New magnet array design for downhole NMR azimuthal measurement

Publication date: Available online 16 October 2018

Source: Magnetic Resonance Imaging

Author(s): Sihui Luo, Lizhi Xiao, Xin Li, Guangzhi Liao, Huabing Liu, Zhengduo Wang, Zhe Sun, Wei Liu, Yangyang Xu

Abstract

In low-field NMR, depth information and radial profile information of downhole formation can be easily acquired with the help of static gradient magnetic field produced by permanent magnets, called downhole NMR imaging. Based on the hypothesis that the formation is homogeneous, average signals detected by centralized or decentralized sensors can provide enough information for petrophysical parameters. In fact, the inhomogeneity of formation may have serious impact on description of the characteristics of formation and oil/gas location which is rarely studied in NMR well-logging. To improve this, we design and implement a new quadrupolar magnet array aimed at achieving azimuthal measurement in this paper. A new quadrupolar magnet array is consisted of four bread-shaped magnets combined with additional small hexangular magnets to produce enough strength and high homogeneity of static field along with circumferential direction at deeper DOI (depth of investigation). Azimuthal measurements are achieved by using coil array combined with quadrupolar magnet array.

https://ift.tt/2EAUC4a

The impact of isolated maternal hypothyroxinemia during the first and second trimester of gestation on pregnancy outcomes: an intervention and prospective cohort study in China

Abstract

Objectives

To explore the effect of isolated maternal hypothyroxinemia (IMH) during the first and second trimester of gestation on pregnancy outcomes. To explore whether levothyroxine (L-T4) treatment of women who had IMH identified in the first trimester improves pregnancy outcomes.

Methods

Women in the early pregnancy in the iodine-sufficient area (n = 3398) were recruited to this prospective cohort study (ChiCTR-TRC-12002326). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibody (TPOAb) were detected. Women with IMH before 12 weeks chose to receive L-T4 or remain untreated. The L-T4 dose was adjusted to attain a normal FT4 and TSH level. Pregnancy outcomes were evaluated during follow-up.

Results

IMH in the first trimester was not associated with increased risk of adverse pregnancy outcome compared with controls. The incidence of macrosomia (p = 0.022) and gestational hypertension (p = 0.018) was significantly higher in IMH identified in the second trimester of gestation compared with controls. IMH identified in the second trimester of gestation was a risk factor for macrosomia [adjusted odds ratio (aOR) 1.942, 95% CI 1.076–3.503, p = 0.027] and gestational hypertension (aOR 4.203, 95% CI 1.611–10.968, p < 0.01), when body mass index in the early pregnancy was < 25 kg/m².

Conclusions

IMH in the first trimester did not increase the risk of adverse outcomes irrespective of whether women received L-T4 treatment. However, IMH identified in the second trimester was associated with increased risk of adverse pregnancy outcome. The results suggest that thyroid function follow-up during the second trimester is necessary, even if thyroid function is normal during the first trimester.

https://ift.tt/2pYhVdN

SHOX gene deletion screening by FISH in children with short stature and Madelung deformity and their characteristics

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2CSbt0k

Basal characteristics and first year responses to human growth hormone (GH) vary according to diagnostic criteria in children with non-acquired GH deficiency (naGHD): observations from a single center over a period of five decades

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2QSQBJt

Helicobacter pylori VacA, a distinct toxin exerts diverse functionalities in numerous cells: An overview

Helicobacter, EarlyView.


https://ift.tt/2EtK9rb

Tattoos among Professional ATP and WTA Tennis Players

Dermatology

https://ift.tt/2AeP4YM

Diagnostic Accuracy of the McGill Thyroid Nodule Score in Pediatric Patients

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2pWdYGD

Issue Information ‐ Instructions for Authors

Clinical Endocrinology, Volume 89, Issue 5, Page 679-680, November 2018.


https://ift.tt/2NKTGsU

Issue Information ‐ TOC and Editorial Board

Clinical Endocrinology, Volume 89, Issue 5, Page 533-534, November 2018.


https://ift.tt/2pWdUqn

Corrigendum: Worse Health‐Related Quality of Life at long‐term follow‐up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN

Clinical Endocrinology, Volume 89, Issue 5, Page 678-678, November 2018.


https://ift.tt/2NKNy3T

Scaffold Materials and Dental Stem Cells in Dental Tissue Regeneration

Abstract

Purpose of Review

Tissue engineering, as a multidisciplinary approach, is a research topic in medicine, but also in dentistry, to build structures, such as enamel, the dentin-pulp complex, the periodontium, or even whole teeth. The purpose of this review is to describe the latest developments in dental tissue engineering, where some of them will change our treatment concepts in dentistry in the near future, and to discuss hurdles and challenges.

Recent Findings

Sophisticated scaffold materials for dental tissue engineering can be fabricated today. No longer only bioinert, but tailor-made for specific applications, biomimetic and bioactive through biochemical and physical cues, growth and differentiation factors, they are able to elicit specific cellular responses, and thus control new tissue formation. Dental stem cells can not only be isolated from various sources but used for their paracrine activity, synergistic effects with epithelial cells exploited, and their behavior modulated by epigenetics. A better understanding of the interplay between cell differentiation and immune and inflammatory stimuli is crucial for the regeneration of tissues, which are constantly confronted with microorganisms. Examples for recent developments include commercially available products for the treatment of initial enamel lesions, a pilot clinical study for dentin-pulp complex regeneration, preclinical trials using cell sheets for periodontal regeneration, and the investigation of various cell sources for whole-tooth engineering.

Summary

This review highlights recent advances in dental tissue engineering, discusses some of the shortcomings and describes visions and future challenges.

https://ift.tt/2OroHaJ

Generalized Fixed Drug Eruption Mimicking CD8+ Cutaneous T‐cell Lymphoma in HIV

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2EoOBHl

Utility of CD30, Ki67 and p53 in assisting with the diagnosis Mycosis Fungoides with Large Cell Transformation

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2RTqO5f

Extensive CD34-to-CD90 Fibroblast Transition Defines Regions of Cutaneous Reparative, Hypertrophic, and Keloidal Scarring

Background: CD90+ fibroblasts have been described arising from and replacing the homeostatic CD34+ network in scleroderma, but have not been specifically examined in other forms of cutaneous fibrosis. Objectives: To address expression, timelines, and spatial relationships of CD90, CD34, and smooth muscle actin (SMA) expressing fibroblasts in scars and to examine for the presence of a CD34-to-CD90 transition. Methods: One hundred and seventeen scars (reparative/hypertrophic/keloidal) were evaluated for CD90, CD34, and SMA expression. Double-staining immunohistochemistry for CD90/CD34 was performed to identify CD90+/CD34+ transitioning cells, confirmed by double-color immunofluorescence. In addition, some scars were double-stained with CD90/SMA, CD90/procollagen-1, or SMA/procollagen-1 to evaluate spatial relationships and active collagen synthesis. Expression was graded as diffuse, minority, and negative. Results: Most scars demonstrate a CD90diffuse/CD34negative/minority pattern, and dual CD90+/CD34+ fibroblasts were observed in 91% of scars. In reparative scars, CD90 expression reverses to a CD34+/CD90− state with maturation. Pathologic scars exhibit prolonged CD90 expression. Both CD90+ and SMA+ fibroblasts collagenize scars, although CD90+ fibroblasts are more prevalent. Conclusions: CD90+ fibroblasts likely arise from the resting CD34+ fibroblastic network. Actively collagenizing scar fibroblasts exhibit a CD90diffuse/CD34negative/minority phenotype, which is prolonged in pathologic scars. CD90+ fibroblasts are likely important players in cutaneous scarring. Correspondence: Jonathan Dale Ho, MBBS, DrSc, DipDermpath, 11 Geranium Path, Mona Heights, Kingston, Jamaica (e-mail: jdho@bu.edu). J. L. Browning and J. Bhawan contributed equally to this work. The authors declare no conflicts of interest. This paper is an original research and was conducted as part of a doctoral thesis. It is not under consideration for publication in any other journal. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2QUbV1e

Tick Bite–Associated Morphea: A Case Report

Abstract: Borrelia burgdorferi, the causative organism of Lyme disease, has been linked to the development of scleroatrophic skin conditions including morphea, although this association remains controversial. The possibility that tick bite with or without concurrent Borrelia infection instigates that morphea development is important to recognize because this could prompt further workup for Lyme disease, or other tick-borne illness, which, when untreated, can have devastating consequences. Here, we report a case of a woman with a history of previous tick bite in the location of morphea. This prompted further workup, including serologies that were negative for borrelia. The patient declined empiric treatment with doxycycline. It is important to be aware that morphea may represent a consequence of tick bite because this can alter patient management. Correspondence: Vladimir Vincek, MD, PhD, Department of Dermatology, University of Florida College of Medicine, 4037 NW 86 Terrace, 4th floor Springhill 4119, Gainesville, FL 32606 (e-mail: Vincek26@dermatology.med.ufl.edu). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2Af8xZh

Noninvasive diagnosis of liquefied gouty tophus: Reflectance confocal microscopy as an alternative to polarizing light microscopy analysis

Skin Research and Technology, EarlyView.


https://ift.tt/2P2NhOt

Use of Absolute Risk Measurements in Dermatologic Observational Studies: Important Information For Decision Making Is Frequently Absent

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NIoOJT

A case of Incontinentia Pigmenti associated with congenital absence of portal vein system and nodular regenerative hyperplasia

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2pYMoIQ

Association of auto‐immunity and long‐term complete remission in Sezary patients treated with mogamulizumab

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NLrw1g

The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population‐based study

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2pWbdFl

The good, the bad and the malignant

British Journal of Dermatology, Volume 179, Issue 4, Page 809-810, October 2018.


https://ift.tt/2NIoIlv

News and Notices

British Journal of Dermatology, Volume 179, Issue 4, Page 1017-1017, October 2018.


https://ift.tt/2pYqh5g

隐性 XLI: 神经系统疾病的高患病率

British Journal of Dermatology, Volume 179, Issue 4, Page e192-e192, October 2018.


https://ift.tt/2NIoECh

Issue Information

British Journal of Dermatology, Volume 179, Issue 4, Page i-v, October 2018.


https://ift.tt/2pYqfKG

An Oral Disease Severity Score for pemphigus vulgaris

British Journal of Dermatology, Volume 179, Issue 4, Page e169-e169, October 2018.


https://ift.tt/2NJZzqr

Editor's Choice

British Journal of Dermatology, Volume 179, Issue 4, Page ix-ix, October 2018.


https://ift.tt/2pYzomA

Revealing the mysteries of X‐linked recessive ichthyosis

British Journal of Dermatology, Volume 179, Issue 4, Page 821-822, October 2018.


https://ift.tt/2NLHx7l

Image Gallery: Granulomatous dermatitis due to infection with the chlorophyllic green alga Desmodesmus

British Journal of Dermatology, Volume 179, Issue 4, Page e167-e167, October 2018.


https://ift.tt/2pWuRAV

The utility of understanding atrophic acne scar formation for prevention and treatment

British Journal of Dermatology, Volume 179, Issue 4, Page 819-819, October 2018.


https://ift.tt/2NN5Q4K

银屑病的生物治疗和癌症风险

British Journal of Dermatology, Volume 179, Issue 4, Page e187-e187, October 2018.


https://ift.tt/2pUwcbk

A promising new treatment for SAPHO syndrome that deserves further studies

British Journal of Dermatology, Volume 179, Issue 4, Page 823-823, October 2018.


https://ift.tt/2NIoDOJ

Can antibiotics be harmful in atopic dermatitis?

British Journal of Dermatology, Volume 179, Issue 4, Page 807-808, October 2018.


https://ift.tt/2pWQJfH

Assessing benefits and risks of holiday sun exposure in children

British Journal of Dermatology, Volume 179, Issue 4, Page 822-823, October 2018.


https://ift.tt/2NJZAdZ

Generating new evidence for old medications: the TREAT trial in paediatric atopic dermatitis

British Journal of Dermatology, Volume 179, Issue 4, Page 813-814, October 2018.


https://ift.tt/2pW73x9

Is the Oral Disease Severity Score going to be useful for dermatologists when assessing pemphigus?

British Journal of Dermatology, Volume 179, Issue 4, Page 816-817, October 2018.


https://ift.tt/2NLRpxP

来自 AD 患者的金黄色葡萄球菌的局部抗生素耐药性

British Journal of Dermatology, Volume 179, Issue 4, Page e188-e188, October 2018.


https://ift.tt/2pXSZTC

Herpesviral Infection in Periapical Periodontitis

Abstract

Purpose of Review

This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings

Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary

Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.

https://ift.tt/2P2D30x