Scholar : CPAP - νέα αποτελέσματα

The infant with severe bronchiolitis: from HFNC to CPAP and mechanical ventilation.

A Wolfler, G Raimondi, C de Paganis Pagan, E Zoia - Minerva pediatrica, 2018

INTRODUCTION: Bronchiolitis is one of the most frequent reasons for PICU
admission in children less than 1 year of age. It causes a wide spectrum of clinical
scenarios from mild to severe respiratory failure and supportive therapy range from …

[PDF] Breathing assist device

CP Hart - US Patent App. 16/003,558, 2018

… of OSA can include lifestyle changes, the use of mechanical devices, such as oral or nasal
devices that augment the airway, surgical procedures to enlarge and stabilize the airway
during sleep, and continuous or variable positive airway pressure (CPAP, VPAP) devices …

FAILING ASTHMATIC

C COMPLAINT - Acute Care Casebook, 2018

… A trial of nonin- vasive positive pressure ventilation is begun using continuous positive
airway pressure (CPAP) while he sits upright on the stretcher … on an infusion of Albuterol
2 g magnesium is now continuously administered inline with the CPAP device …

Ventricular arrhythmias in patients with obstructive sleep apnea.

R Marinheiro, L Parreira, P Amador, D Mesquita… - Current cardiology reviews, 2018

… Treatment of OSA with continuous positive airway pressure (CPAP) has the
potential to reduce arrhythmias and confer a mortality benefit. Read Article
at publisher's site. How does Europe PMC derive its citations network? • Web …

Implication of mixed sleep apnea events in adult patients with obstructive sleep apnea-hypopnea syndrome

X Yang, Y Xiao, B Han, K Lin, X Niu, X Chen - Sleep and Breathing, 2018

… and OSAHS. Yamauchi et al. found that patients with MSA events had significantly
poorer compliance with continuous positive airway pressure (CPAP) as compared
with pure OSAHS patients [7]. Similarly, Xie et al. reported a …

[PDF] Non-invasive mechanical ventilation in COPD

A Fayed - J Pulm Med Resp Dis, 2018

… NIMV is a mechanical respiratory support delivered via an in- terface (eg,
nasal prongs or mask, face mask, or helmet) without the endotracheal
intubation to give a continuous positive airway pressure (CPAP) or bilevel …

Society Guidelines

U TIRODKER - The Pediatric Procedural Sedation Handbook, 2018

… Advanced Life Support (PALS) who monitors the patient but also may assist
in interruptible tasks PALS trained and able to rescue the patient from known
sedation complications, including bag-valve-mask (BVM) and continuous …

[PDF] Connectors for connecting components of a breathing apparatus

RF Flower, CY Lau, PR Kwok, CJ Baxter, AM Ozolins… - US Patent App. 16/004,551, 2018

… conduit delivers pressurized gas from the flow generator to the patient
interface in communication with the patient's upper airways for treatment,
eg, of Sleep Disordered Breathing (SDB) with Positive Airway Pressure …

[PDF] Indian Journal of Nursing Sciences

MS D'Souza, S Balachandran - 2018

… Right hemicolectomy and exploratory laparotomy for small bowel infarction were done.
She is unconscious with sedation and is mechanically ventilated. She is on CPAP/PS
mode of ventilation support through tracheotomy tube No. 8.0 mms …

[HTML] Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth

A Hamvas, R Feng, Y Bi, F Wang, S Bhattacharya… - BMC Genetics, 2018

… This respiratory support included invasive (mechanical ventilation) and non- invasive
(CPAP, high flow nasal cannula > 2 l/min flow) approaches, with or without supplemental
oxygen (ie some infants required respiratory support but with FiO2 0.21) …

 

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Scholar : ΜΕΝΙΕΡΕ - νέα αποτελέσματα

[PDF] Hyperacusis and its Management

AA Danesh - 2018

… Tyler, 2015 Page 7. Other Underlying factors include: • Bell's Palsy •
Temporomandibular joint problems • Central Nervous System damage •
Meniere's Disease • Hypothyroidism • Lyme Disease • PTSD • Depression • …

Hearing function after betahistine therapy in patients with Mé niأ¨ re's disease.

SJ Seyed Tootoonchi, S Ghiasi, P Shadara… - Brazilian journal of …, 2018

VERTIGO—POSTERIOR STROKE

C COMPLAINT - Acute Care Casebook, 2018

… DIFFERENTIAL DIAGNOSES Posterior stroke or hemorrhage Brainstem mass or tumor
Vestibular neuritis Substance use/medication side effects Benign paroxysmal positional
vertigo/Meniere's disease 1. 2. 3. 4. 5. TESTS AND IMAGING Complete blood count: normal …

PENETRATING CHEST TRAUMA

C COMPLAINT - Acute Care Casebook, 2018

Page 381. CHAPTER 7 3 PENETRATING CHEST TRAUMA KATHERINE BIGGS*
SETTING Military Aid Station in a Combat Zone, Surgical Capability CHIEF
COMPLAINT Hit by a Rocket-Propelled Grenade (RPG) HISTORY …

[PDF] HUMAZNIZED AFFINITY MATURED ANIT-FcRn ANTIBODIES

LJ Blumberg, RS Blumberg, SD Jones, D Roopenian… - US Patent App. 15/811,218, 2018

US20180291101A1 - HUMAZNIZED AFFINITY MATURED ANIT-FcRn ANTIBODIES -
Google Patents. HUMAZNIZED AFFINITY MATURED ANIT-FcRn ANTIBODIES.
Download PDF Info. Publication number US20180291101A1 …

[PDF] Single Chain Fc Fusion Proteins

J Alvarez, DT Moustakas, HR Brodkin, LA Mcsweeney - US Patent App. 15/949,596, 2018

US20180289825A1 - Single Chain Fc Fusion Proteins - Google Patents. Single Chain
Fc Fusion Proteins. Download PDF Info. Publication number US20180289825A1.
US20180289825A1 US15949596 US201815949596A US2018289825A1 …

Compositions and methods for the depletion of cd137+ cells

A HARTIGAN, A Boitano, M Cooke, MD Hoban… - US Patent App. 15/875,793, 2018

US20180289832A1 - Compositions and methods for the depletion of cd137+ cells - Google
Patents. Compositions and methods for the depletion of cd137+ cells. Download PDF Info.
Publication number US20180289832A1. US20180289832A1 …

Compounds and methods for promoting stress resistance

C Kenyon, P Zhang, J Cregg, KH Ang, M Arkin - US Patent App. 15/766,797, 2018

US20180289682A1 - Compounds and methods for promoting stress resistance - Google
Patents. Compounds and methods for promoting stress resistance. Download PDF Info.
Publication number US20180289682A1. US20180289682A1 …

 

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Scholar : ΑΠΟΚΑΤΑΣΤΑΣΗ - νέα αποτελέσμ

[PDF] Δυνατότητες ανάπτυξης-αγροτορισμού στην ορεινή Ναυπακτία

ΗΑΜ Μουλάς, ΓΑΜ Μαράτος - 2018

… Χάνι Μπανιά Βλαχοµάνδρας 32.426,07 € ∆ΗΜΟΣ ΠΥΛΗΝΗΣ Αποκατάσταση
υδρόµυλου ∆.∆. Φαµήλας του ∆ήµου Πυλήνης Φαµήλα 56.286,27 € …
Καταφυγίου 468.600,00 € ΚΑΛΟΓΕΡΗΣ ΑΝ∆ΡΕΑΣ Αποκατάσταση εξωτερικών …

 

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Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα

Technical Annexes

DA Bradt, CM Drummond - Reference Manual for Humanitarian Health …, 2019

Page 1. 151 © David A. Bradt 2019 DA Bradt, CM Drummond, Reference Manual
for Humanitarian Health Professionals, https://ift.tt/2JlDK01
Technical Annexes Guidance Notes These annexes contain …

 

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Scholar : Laryngomalacia - νέα αποτελέσματα

Standards for pediatric FAE and sedation have been published separately, although standards for sedation specific to FAE in children have not.

P Assessment - The Pediatric Procedural Sedation Handbook, 2018

The Premature Infant

JE HAVIDICH, RH EVANS - The Pediatric Procedural Sedation Handbook, 2018

 

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The different roles of 5-HT1A/2A receptors in fluoxetine ameliorated pigmentation of C57BL/6 mouse skin in response to stress

Publication date: Available online 25 October 2018

Source: Journal of Dermatological Science

Author(s): Liangliang Zhou, Minxuan Cai, Yingying Ren, Huali Wu, Meng Liu, Haijuan Chen, Jing Shang

Abstract

Background

5-HT1 A receptor was participated in fluoxetine induced melanogenesis in melanocytes and in normal C57BL/6 mice, but we know little about whether other 5-HT receptors are involved in regulation of fluoxetine promotes pigmentation.

Objective

To investigate the role of 5-HT receptors in regulation of fluoxetine ameliorates chronic unpredictable mild stress (CUMS) and chronic restraint stress (CRS) induce hypopigmentation in C57BL/6 mice.

Methods

CUMS and CRS were used to induce depigmentation in mice and evaluate the effect of fluoxetine. Western blot, immunohistochemistry and Q-PCR assay were used to determine the levels of protein and mRNA. Masson Fontana staining was used for melanin staining and FITC-Phalloidin staining was used to detect the expression of F-actin. Zebrafish and B16F10 cells were used for the mechanism research.

Results

Fluoxetine (2.6 mg/kg, ig) ameliorated hypopigmentation induced by CUMS and CRS in mice, significantly increased the mRNA and protein levels of 5-HT1 A and 5-HT2 A receptors in mice and B16F10 cells. The effect of fluoxetine on melanogenesis in B16F10 cells and zebrafish were inhibited by WAY100635 (a selective 5-HT1 A receptor antagonist) and ketanserin (a 5-HT2 A receptor antagonist), respectively. Activation of p38 MAPK signaling pathways was contributed to fluoxetine induced melanogenesis and inhibited by WAY100635, but not ketanserin. However, ketanserin selectively weakened the action of fluoxetine promoted migration and up-regulated Rab27a protein expression in B16F10 cells.

Conclusions

5-HT1 A and 2 A receptors contribute to melanogenesis and migration property of fluoxetine. The newly revealed mechanism indicates that fluoxetine and its analogues may be a potential drug for treatment of depigmentation disorders.

Graphical Abstract

Stress, specifically chronic unpredictable stress and chronic restrained stress, induce depigmentation in C57BL/6 mice. Fluoxetine promoted melanin production and the migration of melanocytes via 5-HT1 A receptor and 5-HT2 A receptor, respectively.

https://ift.tt/2z0roW3

Conflict of interest and citation impact among dermatology guideline authors

Publication date: Available online 24 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Kamber Loren Hart, Roy Howard Perlis, Clifford Scott Perlis

https://ift.tt/2PPllL7

Cryotherapy vs trichloroacetic acid 90% in treatment of common warts

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2Sh9veC

Treatment of Grade I and II types of xanthelasma palpebrarum with intralesional heparin sodium

Dermatologic Therapy, EarlyView.


https://ift.tt/2OOs77I

Neoadjuvant intralesional methotrexate in squamous cell carcinoma of the lip

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2Piwqro

A 5α‐reductase (SRD5A2) polymorphism is associated with serum testosterone and sex hormone‐binding globulin in men, while aromatase (CYP19A1) polymorphisms are associated with estradiol and luteinising hormone reciprocally

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Jh2whN

Saliva – A Promising Tool for Diagnosing Oral Diseases

Abstract

Purpose of Review

This review will present updates on the genome, transcriptome, proteome, metabolome, exosome, and microbiome of saliva and the wide range of biomarkers found within these salivary components. We will explore the effectiveness and potential of salivary diagnostics on specific diseases: dental caries and demineralization diseases, periodontal diseases and peri-implantitis, oral cancers, and Sjögren's syndrome.

Recent Findings

Recent studies have shown the feasibility of saliva as a diagnostic tool, in addition to the emergence of many novel salivary biomarkers. Unfortunately, many of these studies do not explore further into the outcomes of patient-oriented health and do not demonstrate reliability in diverse patient populations.

Summary

Salivary diagnostics is an emerging field that uses saliva, for its non-invasive, fast, and cost-effective collection properties, as a diagnostic tool. In the near future, we expect that salivary diagnostics will benefit from technological advances and further studies to be used as a routine chair-side test included in a comprehensive diagnostic and risk assessment tool.

https://ift.tt/2yAA0mX

Tooth Repair and Regeneration

Abstract

Purpose of Review

Current dental treatments are based on conservative approaches, using inorganic materials and appliances.

This report explores and discusses the newest achievements in the field of "regenerative dentistry," based on the concept of biological repair as an alternative to the current conservative approach.

Recent Findings

The review covers and critically analyzes three main approaches of tooth repair: the re-mineralization of the enamel, the biological repair of dentin, and whole tooth engineering.

Summary

The development of a concept of biological repair based on the role of the Wnt signaling pathway in reparative dentin formation offers a new translational approach into development of future clinical dental treatments.

In the field of bio-tooth engineering, the current focus of the researchers remains the establishment of odontogenic cell-sources that would be viable and easily accessible for future bio-tooth engineering.

https://ift.tt/2NZroeB

Oral Polymorphonuclear Neutrophil Contributes to Oral Health

Abstract

Purpose of Review

Oral health is maintained in a dynamic equilibrium between the host immunity and the oral microbiome. Oral polymorphonuclear neutrophils (oPMNs) are important innate immune cells in the oral cavity.

Recent Findings

The oPMNs play a co-controlling part in the maintenance of oral equilibrium. In human saliva, the oPMNs integrity is preserved, and their function remains unaffected. In general, oPMNs are in a higher state of baseline activation compared to peripheral PMNs. However, in periodontitis, the oPMNs' activation state can result in excessive release of damaging molecules in the extracellular environment.

Summary

The presence of oPMNs may unwittingly negatively impact the integrity of the oral tissues. While most of the oPMN functions occur intracellularly, release of their potent active mediators into the extracellular environment may jeopardize oral homeostasis and its integrity. The dual nature of oPMNs, both beneficial and detrimental, remains a challenging and understudied topic.

https://ift.tt/2ywaTBW

Cross-transmission in the Dental Office: Does This Make You Ill?

Abstract

Purpose of Review

Recently, numerous scientific publications were published which shed new light on the possible risks of infection for dental healthcare workers and their patients. This review aimed to provide the latest insights in the relative risks of transmission of (pathogenic) micro-organisms in the dental office.

Recent Findings

Of all different routes of micro-organism transmission during or immediately after dental treatment (via direct contact/via blood-blood contact/via dental unit water and aerosols), evidence of transmission is available. However, the recent results put the risks in perspective; infections related to the dental office are most likely when infection control measures are not followed meticulously.

Summary

The risk for transmission of pathogens in a dental office resulting in an infectious disease is still unknown; it seems to be limited in developed countries but it cannot be considered negligible. Therefore, maintaining high standards of infection preventive measures is of high importance for dental healthcare workers to avoid infectious diseases due to cross-contamination.

https://ift.tt/2NZrm6t

Apremilast as therapeutic option in a HIV positive patient with severe psoriasis

Dermatologic Therapy, EarlyView.


https://ift.tt/2EE7R3Q

Eating disorders in premenstrual dysphoric disorder: a neuroendocrinological pathway to the pathogenesis and treatment of binge eating

Abstract

Background

This case report details the presentation, treatment and post-operative outcome of an adult female with co-occurring binge eating disorder and premenstrual dysphoric disorder (PMDD).

Case presentation

The patient, self-presenting for treatment, reported having struggled with severe, debilitating physical and psychological PMDD symptoms for nearly a decade. After having taken part in a number of unsuccessful first- and second line treatments in primary and secondary care, the patient was referred to tertiary care at the Department of Gynecology at Oslo University Hospital in Norway. Chemical menopause using a gonadotropin-releasing hormone (GnRH) agonist was induced, predicting the desired response (i.e. resolution of PMDD symptoms) to bilateral salpingo-oophorectomy (BSO). At three- and six months post BSO follow-up, the patient reported complete resolution of all reported PMDD symptoms including marked increase in appetite (i.e. hyperphagia), specific food cravings and auxiliary binge eating.

Conclusions

To our knowledge, this is the first case documenting the recovery from an eating disorder following surgical ovarian suppression. Our findings lend supports to existing studies linking binge eating to hormonal changes in the mid-luteal phase of the menstrual cycle, and may help advance new treatment options for a selected, severely impaired group of females struggling with excessive appetite and binge eating due to fluctuations in ovarian activity.

https://ift.tt/2Rg7SfX

Symptom Expression in Patients with Advanced Cancer Admitted to an Acute Supportive/Palliative Care Unit With and Without Delirium

AbstractAim.The aim of this study was to investigate the relationship between delirium and symptom expression in patients with advanced cancer admitted to an acute supportive/palliative care unit (ASPCU).Methods.A consecutive sample of patients with advanced cancer who were admitted to an ASPCU was prospectively assessed for a period of 10 months. The Edmonton Symptom Assessment Scale (ESAS) and the MDAS (Memorial Delirium Assessment Scale) were measured at admission (T0) and after 7 days of palliative care (T7).Results.Two hundred forty‐six patients had complete data regarding MDAS measurements, at either T0 and T7. Of these, 75 (30.5%) and 63 patients (25.6%) had delirium at T0 and after a week of palliative care (T7), with a decrease in the frequency of delirium of 4.9% (from 30.5% to 25.6%); that means that 16% of patients with delirium improved their cognitive status after initiation of palliative care. Intensities of pain, depression, poor well‐being, and global ESAS were significantly higher in patients with delirium. Patients who did not have delirium at T0 but developed delirium during admission after 1 week of palliative care had a higher level of symptom expression for pain, weakness, nausea, anxiety, dyspnea, appetite, and consequently global ESAS. Patients who did not develop delirium at any time had a relevant decrease in intensity of all ESAS items after 1 week of palliative care. The decrease of symptom intensity was significant for pain, insomnia, appetite, poor well‐being, and global ESAS in patients with delirium either at T0 and T7, although these differences were less relevant than those observed in patients without delirium. In patients with delirium at T0 who improved their cognitive function at T7 (no delirium), significant changes were found in most ESAS items.Conclusion.Symptom expression is amplified in patients with delirium, whereas patients without delirium may be more responsive to palliative treatments with a significant decrease in intensity of ESAS items.Implications for Practice.Symptom expression is amplified in patients with cancer who have delirium, whereas patients without delirium may be more responsive to palliative treatments with a significant decrease in symptom intensity.

https://ift.tt/2Ar4VmU

Effect of Lanreotide Depot/Autogel on Urinary 5‐Hydroxyindoleacetic Acid and Plasma Chromogranin A Biomarkers in Nonfunctional Metastatic Enteropancreatic Neuroendocrine Tumors

AbstractBackground.Urinary 5‐hydroxyindoleacetic acid (5‐HIAA) is an established biomarker in neuroendocrine tumors and carcinoid syndrome; however, its role in nonfunctional neuroendocrine tumors is not defined. We present post hoc data on urinary 5‐HIAA and plasma chromogranin A (CgA) from the CLARINET study.Methods.Patients with well‐ or moderately differentiated, nonfunctioning, locally advanced or metastatic enteropancreatic neuroendocrine tumors were randomized to deep subcutaneous lanreotide depot/autogel 120 mg or placebo once every 28 days for 96 weeks. Tumor response, evaluated centrally (RECIST 1.0), and progression‐free survival (PFS) were assessed by treatment and biochemical response, defined as (a) baseline >upper limit of normal (ULN, 41.6 μmol per day 5‐HIAA; 98.1 μg/L CgA) and (b) ≥50% decrease from baseline and to ≤ULN value on study.Results.Forty‐eight percent (82 of 171; lanreotide, n = 45; placebo, n = 37) and 66% (129 of 195; lanreotide, n = 65; placebo, n = 64) of randomized patients had 5‐HIAA and CgA > ULN at baseline. Among patients with >ULN baseline values who did not progress after 96 weeks of treatment, significantly greater reductions in 5‐HIAA and CgA were observed in lanreotide‐treated versus placebo‐treated patients throughout the study (all p < .05). PFS was significantly prolonged among 5‐HIAA responders versus nonresponders (median not reached vs. 16.2 months, p < .0001; hazard ratio [HR] = 0.21, 95% confidence interval [CI], 0.09–0.48) and CgA responders versus nonresponders (median not reached vs. 16.2 months, p = .0070; HR = 0.30, 95% CI, 0.12–0.76), regardless of treatment arm. PFS was also significantly prolonged among lanreotide‐treated 5‐HIAA responders versus nonresponders (p = .0071) but was not significantly different among placebo‐treated 5‐HIAA responders versus nonresponders. There were no significant differences in PFS between lanreotide‐treated CgA responders versus nonresponders or between placebo‐treated CgA responders versus nonresponders.Conclusions.The 5‐HIAA findings are noteworthy because they occurred in patients with nonfunctioning enteropancreatic neuroendocrine tumors. Monitoring 5‐HIAA and CgA may be useful when treating patients with nonfunctional neuroendocrine tumors.Implications for Practice.Current guidelines focus only on the monitoring of 5‐hydroxyindoleacetic acid (5‐HIAA) in the diagnosis and management of functional neuroendocrine tumors with carcinoid syndrome. The current post hoc analysis of patients with nonfunctional enteropancreatic neuroendocrine tumors in the CLARINET study demonstrated that measuring and following both 5‐HIAA and chromogranin A as biomarkers of disease progression may be useful in the management of patients with nonfunctional neuroendocrine tumors.

https://ift.tt/2POY0cC

Cases from the irAE Tumor Board: A Multidisciplinary Approach to a Patient Treated with Immune Checkpoint Blockade Who Presented with a New Rash

AbstractImmune checkpoint inhibitors (ICIs) have revolutionized the treatment paradigms for a broad spectrum of malignancies. Because immune checkpoint inhibitors rely on immune reactivation to eliminate cancer cells, they can also lead to the loss of immune tolerance and result in a wide range of phenomena called immune‐related adverse events (irAEs). At our institution, the management of irAEs is based on multidisciplinary input obtained at an irAE tumor board that facilitates expedited opinions from various specialties and allows for a more uniform approach to these patients. In this article, we describe a case of a patient with metastatic urothelial carcinoma who developed a maculopapular rash while being treated with a programmed death‐ligand 1 inhibitor. We then describe the approach to management of dermatologic toxicities with ICIs based on the discussion at our irAE Tumor Board.Key Points. Innocuous symptoms such as pruritis or a maculopapular rash may herald potentially fatal severe cutaneous adverse reactions (SCARs); therefore, close attention must be paid to the symptoms, history, and physical examination of all patients.Consultation with dermatology should be sought for patients with grade 3 or 4 toxicity or SCARs and prior to resumption of immune checkpoint inhibitors for patients with grade 3 or higher toxicity.A multidisciplinary immune‐related adverse events (irAE) tumor board can facilitate timely input and expertise from various specialties, thereby ensuring a streamlined approach to management of irAEs.

https://ift.tt/2As7DbY

Conflicts of Interest, Baselga, and Clinical Trialists

https://ift.tt/2PT8mbD

Flap Reconstruction of Sarcoma Defects in the Setting of Neoadjuvant and Adjuvant Radiation

J reconstr Microsurg
DOI: 10.1055/s-0038-1675147

Purpose Limb-sparing treatment of extremity soft tissue sarcomas requires wide resections and radiation therapy. The resulting complex composite defects necessitate reconstructions using either muscle or fasciocutaneous flaps, often in irradiated wound beds. Methods A retrospective chart review was performed of all limb-sparing soft tissue sarcoma resections requiring immediate flap reconstruction from 2012 through 2016. Results Forty-four patients with 51 flaps were identified: 25 fasciocutaneous and 26 muscle-based flaps. Mean defect size, radiation treatment, and follow-up length were similar between groups. More often, muscle-based flaps were performed in younger patients and in the lower extremity. Seventeen flaps were exposed to neoadjuvant radiation, 12 to adjuvant radiation, 5 to both, and 17 to no radiation therapy. Regardless of radiation treatment, complication rates were comparable, with 28% in fasciocutaneous and 31% in muscle-based groups (p < 0.775). Muscle-based flaps performed within 6 weeks of undergoing radiotherapy were less likely to result in complications than those performed after greater than 6 weeks (p < 0.048). At time of follow-up, Musculoskeletal Tumor Society scores for fasciocutaneous and muscle-based reconstructions, with or without radiation, showed no significant differences between groups (mean [SD]: 91% [8%] vs. 89% [13%]). Conclusions The similar complication rates and functional outcomes in this study support the safety and efficacy of both fasciocutaneous flaps and muscle-based flaps in reconstructing limb-sparing sarcoma resection defects, with or without radiotherapy.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2qaGLak

Actinomyces Orbital Osteomyelitis in the Setting of Multiple Myeloma and Bisphosphonate-Related Osteonecrosis

No abstract available

https://ift.tt/2qadZ9U

Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma

Background: To describe a case of optic neuropathy associated with intravascular lymphoma (IVL). Methods: Case report and review of the literature. Results: A case of asymmetric binocular vision loss is described, preceded by transient vision loss. Associated optic perineural enhancement and enhancing and diffusion-positive cortical lesions were observed on magnetic resonance imaging. Biopsy of the cerebellum revealed exclusively intraluminal neoplastic B-cells consistent with IVL. Conclusions: Patients with IVL may rarely present with optic nerve involvement, presumably due to small vessel occlusion. The presentation may mimic features of anterior ischemic optic neuropathy including an acute onset and disc edema. Although optic nerve enhancement and associated white matter lesions may suggest optic neuritis, enhancement of the optic nerve sheath, as in this case, has a wide differential diagnosis, which includes giant cell arteritis. IVL should be considered in atypical cases of optic neuropathy accompanied by enhancing, diffusion-positive brain lesions that are not within a specific vascular territory. Address correspondence to Marc Dinkin, MD, Weill Cornell Ophthalmology, 1305 York Avenue, 11th Floor, New York, NY 10065; E-mail: mjd2004@med.cornell.edu The authors report no conflicts of interest. © 2018 by North American Neuro-Ophthalmology Society

https://ift.tt/2Rc1Xsi

What to know about microdermabrasion

Microdermabrasion is a cosmetic procedure, during which a dermatologist removes the top layer of skin. The aim is to create a more youthful, even complexion. Learn more here.

https://ift.tt/2EIQD5u

Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD- scid gamma mice and sprague dawley rats

Abstract

Purpose

The aromatase inhibitor, letrozole, is being investigated in experimental animal models as a novel treatment for high-grade gliomas (HGGs). To facilitate optimal dosing for such studies, we evaluated the plasma and brain pharmacokinetics (PK) of letrozole in NOD-scid gamma (NSG) mice, which are frequently employed for assessing efficacy against patient-derived tumor cells. Furthermore, we evaluated the potential PK interactions between letrozole and temozolomide (TMZ) in Sprague–Dawley rats.

Methods

NSG mice were administered letrozole (8 mg/kg; i.p) as a single or multiple dose (b.i.d, 10 days). Brain tissue and blood samples were collected over 24 h. Letrozole and TMZ interaction study employed jugular vein-cannulated rats (three groups; TMZ alone, letrozole alone and TMZ + letrozole). Intracerebral microdialysis was performed for brain extracellular fluid (ECF) collection simultaneously with venous blood sampling. Drug levels were measured employing HPLC and PK analysis was conducted using Phoenix WinNonlin^®.

Results

In NSG mice, peak plasma and brain tissue letrozole concentrations (C_max) were 3–4 and 0.8–0.9 µg/ml, respectively. The elimination half-life was 2.6 h with minimal accumulation following multiple dosing. In the drug interaction study, no PK changes were evident when TMZ and letrozole were given in combination. For instance, peak plasma and brain ECF TMZ levels when given alone were 14.7 ± 1.1 and 4.6 ± 0.6 µg/ml, respectively, and 12.6 ± 2.4 and 3.4 ± 0.8 µg/ml, respectively, when given with letrozole.

Conclusions

These results will guide the optimization of dosing regimen for further development of letrozole for HGG treatment.

https://ift.tt/2OJoCPQ

The Prevalence of Soft Tissue Calcifications in the Head and Neck Region Using CBCT Among Egyptian Population

Condition:   Oral Soft Tissue Conditions
Intervention:   Other: presence of soft tissue calcification in head and neck
Sponsors:   Maha Samy Elhadidy;   Cairo University
Not yet recruiting

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Dopamine Signaling Modulates the Stability and Integration of Intrinsic Brain Networks

Abstract

Dopaminergic projections are hypothesized to stabilize neural signaling and neural representations, but how they shape regional information processing and large-scale network interactions remains unclear. Here we investigated effects of lowered dopamine levels on within-region temporal signal variability (measured by sample entropy) and between-region functional connectivity (measured by pairwise temporal correlations) in the healthy brain at rest. The acute phenylalanine and tyrosine depletion (APTD) method was used to decrease dopamine synthesis in 51 healthy participants who underwent resting-state functional MRI (fMRI) scanning. Functional connectivity and regional signal variability were estimated for each participant. Multivariate partial least squares (PLS) analysis was used to statistically assess changes in signal variability following APTD as compared with the balanced control treatment. The analysis captured a pattern of increased regional signal variability following dopamine depletion. Changes in hemodynamic signal variability were concomitant with changes in functional connectivity, such that nodes with greatest increase in signal variability following dopamine depletion also experienced greatest decrease in functional connectivity. Our results suggest that dopamine may act to stabilize neural signaling, particularly in networks related to motor function and orienting attention towards behaviorally-relevant stimuli. Moreover, dopamine-dependent signal variability is critically associated with functional embedding of individual areas in large-scale networks.

https://ift.tt/2JdtNl7

Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo

Abstract

Parcellation of distinct areas in the cerebral cortex has a long history in neuroscience and is of great value for the study of brain function, specialization, and alterations in neuropsychiatric disorders. Analysis of cytoarchitectonical features has revealed their close association with molecular profiles based on protein density. This provides a rationale for the use of in vivo molecular imaging data for parcellation of the cortex with the advantage of whole-brain coverage. In the current work, parcellation was based on expression of key players of the serotonin neurotransmitter system. Positron emission tomography was carried out for the quantification of serotonin 1A (5-HT_1A, n = 30) and 5-HT_2A receptors (n = 22), the serotonin-degrading enzyme monoamine oxidase A (MAO-A, n = 32) and the serotonin transporter (5-HTT, n = 24) in healthy participants. Cortical protein distribution maps were obtained using surface-based quantification. Based on k-means clustering, silhouette criterion and bootstrapping, five distinct clusters were identified as the optimal solution. The defined clusters proved of high explanatory value for the effects of psychotropic drugs acting on the serotonin system, such as antidepressants and psychedelics. Therefore, the proposed method constitutes a sensible approach towards integration of multimodal imaging data for research and development in neuropharmacology and psychiatry.

https://ift.tt/2yyMrzC

Neuronal Distribution Across the Cerebral Cortex of the Marmoset Monkey (Callithrix jacchus)

Abstract

Using stereological analysis of NeuN-stained sections, we investigated neuronal density and number of neurons per column throughout the marmoset cortex. Estimates of mean neuronal density encompassed a greater than 3-fold range, from >150 000 neurons/mm³ in the primary visual cortex to ~50 000 neurons/mm³ in the piriform complex. There was a trend for density to decrease from posterior to anterior cortex, but also local gradients, which resulted in a complex pattern; for example, in frontal, auditory, and somatosensory cortex neuronal density tended to increase towards anterior areas. Anterior cingulate, motor, premotor, insular, and ventral temporal areas were characterized by relatively low neuronal densities. Analysis across the depth of the cortex revealed greater laminar variation of neuronal density in occipital, parietal, and inferior temporal areas, in comparison with other regions. Moreover, differences between areas were more pronounced in the supragranular layers than in infragranular layers. Calculations of the number of neurons per unit column revealed a pattern that was distinct from that of neuronal density, including local peaks in the posterior parietal, superior temporal, precuneate, frontopolar, and temporopolar regions. These results suggest that neuronal distribution in adult cortex result from a complex interaction of developmental/ evolutionary determinants and functional requirements.

https://ift.tt/2JdtzdL

Scholar : Archives of Agronomy and Soil Science, Volume 64, Issue 14, December 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Archives of Agronomy and Soil Science, Volume 64, Issue 14, December 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Short Communications Effect of grassland harvesting frequency and N-fertilization on stocks and dynamics of soil organic matter in the temperate climate Anja Nüsse, Deborah Linsler, Ralf Loges, Thorsten Reinsch, Friedhelm Taube & Bernard Ludwig Pages: 1925-1931 | DOI: 10.1080/03650340.2018.1468561 Original Articles Integrated agricultural management practice improves soil quality in Northeast China Luying Sun, Fengbin Song, Shengqun Liu, Qingjun Cao, Fulai Liu & Xiancan Zhu Pages: 1932-1943 | DOI: 10.1080/03650340.2018.1468077 Nitrogen use efficiency and nutrient partitioning in maize as affected by blends of controlled-release and conventional urea Pedro Lopes Garcia, Hugo Abelardo González-Villalba, Renata Alcarde Sermarini & Paulo Cesar Ocheuze Trivelin Pages: 1944-1962 | DOI: 10.1080/03650340.2018.1469746 Effects of three biochar types on activity of β-glucosidase enzyme in two agricultural soils of different textures Elif Günal, Halil Erdem & Ahmet Demirbaş Pages: 1963-1974 | DOI: 10.1080/03650340.2018.1471205 Nagina 22 mutants tolerant or sensitive to low P in field show contrasting response to double P in hydroponics and pots Poli Yugandhar, Veronica Nallamothu, Madhusmita Panigrahy, Sitaramamma Tipireddy, Vijai Pal Bhadana, Sitapathi Rao Voleti, Subrahmanyam Desiraju, Satendra Kumar Mangrauthia & Sarla Neelamraju Pages: 1975-1987 | DOI: 10.1080/03650340.2018.1471684 Contribution of non-exchangeable potassium on its quantity-intensity relationships under K-depleted soils Fotis Bilias & Nikolaos Barbayiannis Pages: 1988-2004 | DOI: 10.1080/03650340.2018.1472376 Effects of drought stress on some agronomic and bio-physiological traits of Trititicum aestivum, Triticale, and Tritipyrum genotypes Mahdi Shanazari, Pooran Golkar & Ali Mohammad Mirmohammady Maibody Pages: 2005-2018 | DOI: 10.1080/03650340.2018.1472377 Change in SOC content in a small karst basin for the past 35 years and its influencing factors Zhenming Zhang, Yunchao Zhou, Shijie Wang & Xianfei Huang Pages: 2019-2029 | DOI: 10.1080/03650340.2018.1474520 Assessment of soil quality monitoring indicators under long term rice cultivation in hot arid Ghaggar-flood plains of India Pravash Chandra Moharana, Ram Sakal Singh, Surendra Kumar Singh, Roomesh Kumar Jena, Ravindra Kashinath Naitam, Thakur Prasad Verma, Mahaveer Nogiya, Roshan Lal Meena, Dipak Kumar Gupta, Sunil Kumar, Bhagwati Lal Tailor & Rameshwar Singh Pages: 2030-2044 | DOI: 10.1080/03650340.2018.1476755 Root system response of selected lowland Thai rice varieties as affected by cultivation method and potassium rate under alternate wetting and drying irrigation Hayat Ullah & Avishek Datta Pages: 2045-2059 | DOI: 10.1080/03650340.2018.1476756 Olive mill wastewater spreading and AMF inoculation effects in a low-input semi-arid Mediterranean crop succession Caterina Caruso, Carmelo Maucieri, Valeria Cavallaro, Maurizio Borin & Antonio C. Barbera Pages: 2060-2074 | DOI: 10.1080/03650340.2018.1476970 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

The clinical usage and definition of autoantibodies in immune-mediated liver disease: A comprehensive overview

Publication date: Available online 23 October 2018

Source: Journal of Autoimmunity

Author(s): Benedetta Terziroli Beretta-Piccoli, Giorgina Mieli-Vergani, Diego Vergani

Abstract

Autoimmune serology is key to the diagnosis and management of autoimmune liver diseases. Its correct use in clinical practice requires a basic knowledge of the laboratory techniques used for autoantibody detection. Indirect immunofluorescence (IIF) on triple rodent tissue is still the gold standard screening procedure for liver-relevant autoantibodies, while HEp2 cells and human ethanol-fixed neutrophils are used as substrates to characterize nuclear reactivities and to detect anti-neutrophil cytoplasm antibody, respectively. Assays based on purified or recombinant antigens are increasingly used, having the main advantage of being observer-independent and the disadvantage of detecting only autoantibodies whose antigenic target has been identified. The AIH-specific anti-soluble liver antigen antibody cannot be detected by IIF and a molecular-based assay should be used at the screening level. Since autoantibodies may be present in the context of viral hepatitides and other inflammatory liver diseases it is important to exclude these conditions before diagnosing autoimmune liver disease. Anti-nuclear antibody (ANA), most often with a homogeneous IIF pattern on HEp2 cells, characterizes type 1 autoimmune hepatitis (AIH), and is found in association with anti-smooth muscle antibody in about half of the cases. Two IIF ANA patterns are specific for primary biliary cholangitis, namely the rim-like/membranous pattern, and the multiple nuclear dots pattern. Anti-liver kidney microsomal antibody type 1 is the serological hallmark of type 2 AIH, often in association with anti-liver cytosol type 1 antibody. Atypical perinuclear anti-neutrophil antibody, referred to as perinuclear anti-neutrophil nuclear antibody, is frequently detected in primary sclerosing cholangitis, in AIH type 1 and in inflammatory bowel diseases. The anti-asiaglycoprotein receptor antibody is liver-specific but not disease-specific, and reliable commercial assays for its detection are lacking. Anti-mitochondrial antibody is the hallmark of primary biliary cholangitis (PBC), being disease-specific and present in about 95% of the PBC patients. Its incidental detection presages the future development of PBC.

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Autoimmune sclerosing cholangitis: Evidence and open questions

Publication date: Available online 23 October 2018

Source: Journal of Autoimmunity

Author(s): Benedetta Terziroli Beretta-Piccoli, Diego Vergani, Giorgina Mieli-Vergani

Abstract

Juvenile sclerosing cholangitis is a rare chronic hepatobiliary disorder characterized by inflammation of the intra- and/or extrahepatic bile ducts, bile duct dilatation, narrowing and obliteration, and, histologically, by inflammatory bile duct damage leading to periductular fibrosis. The diagnosis is based on endoscopic retrograde cholangiopancreatography or magnetic resonance cholangiopancreatography. In children, it may be associated to a variety of systemic and hepatic conditions: thus, the term "primary" sclerosing cholangitis should be reserved for the rare cases without a known cause. Small duct disease is diagnosed in the presence of histological features diagnostic of sclerosing cholangitis and normal cholangiography. Autoimmune sclerosing cholangitis (ASC) is a form of sclerosing cholangitis with strong autoimmune features overlapping with those of autoimmune hepatitis (AIH). It is a well-recognized nosological entity in paediatrics, where it accounts for the majority of sclerosing cholangitis cases. It is as prevalent as AIH in children, is equally frequent in males and females, half of the patients have concomitant inflammatory bowel disease, virtually all patients have raised immunoglobulin G levels and positive anti-nuclear and/or anti-smooth muscle antibodies. Half of the ASC patients respond well to standard immunosuppressive treatment for AIH with the addition of ursodeoxycholic acid, but the transplant rate is higher than in AIH, and post-transplant recurrence is frequent. A number of open questions remain: are ASC and AIH distinct entities or different manifestations of the same condition? What is the role of histology? Is small duct disease a specific entity? What is the relationship between ASC and adult primary sclerosing cholangitis? What is the role of inflammatory bowel disease? In addition, validated diagnostic criteria for ASC are needed.

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Treatment of primary non-metastatic melanoma at high-volume academic facilities is associated with improved long-term patient survival

Publication date: Available online 23 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Shayan Cheraghlou, George O. Agogo, Michael Girardi

Abstract

Background

Previous studies of cancer care have demonstrated improved long-term patient outcomes for those treated at high-volume centers. The influence of treatment center characteristics on outcomes for primary non-metastatic melanoma is not currently established.

Objective

We aimed to investigate the association of cancer treatment center case volume and academic affiliation on long-term patient survival for cases of primary non-metastatic melanoma.

Methods

US adult melanoma cases diagnosed from 2004-2014 in the NCDB were identified. Hospitals were grouped by yearly case volume quartile: bottom quartile, middle quartiles, and top quartile.

Results

Facility case volume was significantly associated with long-term patient survival (p<0.0001). Five-year survival was 76.8%, 81.9%, and 86.4% respectively for patients treated at institutions in the bottom, middle, and top quartiles of case volume respectively. On multivariate analysis, treatment at both middle-quartile (HR 0.834;95% CI 0.778-0.895) and top-quartile (HR 0.691;95% CI 0.644-0.741) volume centers was associated with improved survival relative to bottom-quartile volume hospitals. Academic affiliation was associated with improved outcomes for top-quartile but not middle-quartile volume facilities.

Limitations

Disease-specific survival was not available.

Conclusions

Treatment at a high-volume facility is associated with improved long-term patient survival for melanoma. High-volume academic centers have improved patient outcomes compared to other high-volume centers.

https://ift.tt/2ywzGWf

Scholar : New articles have been published for Journal of Natural History, Volume 52, Issue 35-36

The online platform for Taylor & Francis Online content The following articles have been newly published in the issue Journal of Natural History, Volume 52, Issue 35-36 on Taylor & Francis Online: Articles Descriptions of two new genera, six new species and three new records of Anthozoa (Cnidaria) from the Sea of Marmara Oscar Ocaña, Melih Ertan Çinar Pages: 2243-2282 | DOI: 10.1080/00222933.2018.1526345 The issue is in progress. To view all articles already published in this issue, please visit: https://www.tandfonline.com/toc/tnah20/52/35-36 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Endocrine Pathology Society Hubert Wolfe Award for 2018: Call for Nominations

https://ift.tt/2PS7rrU

Asymptomatic perianal papules in a 75‐year‐old man

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2R91AOZ

Red crateriform tumour on the scalp

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2AqILRZ

Dermoscopy of folliculosebaceous cystic hamartoma

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2O2VzS2

Delayed angioedema of the unilateral tongue associated with angiotensin II receptor blocker in a patient with polypharmacy

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2OL7pWl

Volume outlier benchmark proposal for Australian Mohs surgery

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2O2YEBJ

Effects of CYP2D6 * 10 polymorphism on tamoxifen pharmacokinetics in patients with breast cancer in Asia: a meta-analysis

Abstract

Purpose

Insufficient serum metabolite concentrations of tamoxifen can compromise treatment efficacy in patients with breast cancer. The purpose of this meta-analysis was to explore correlations between cytochrome P450 (CYP) 2D6*10 gene polymorphisms and serum concentrations of tamoxifen and its active metabolites in patients with breast cancer in Asia.

Methods

The study included a systematic literature search for cohort studies published before March 2018 in English databases (PubMed, Embase, Cochrane Library, and Web of Science) and Chinese databases (Chinese National Knowledge Infrastructure and Wan Fang database). The meta-analysis was performed using RevMan 5.3 software. Pooled means and standard deviations were calculated with 95% confidence intervals. Publication bias and sensitivity analyses were also performed using STATA 14.0.

Results

In total, 7 studies and 552 patients were included in the meta-analysis. Serum concentrations of endoxifen were significantly different in each CYP2D6*10 genotype group (p < 0.05). The CC genotype was associated with higher concentrations of 4-OH-TAM than the CT/TT genotype (p < 0.05). However, there were no statistically significant between-group differences in serum concentrations of TAM (p > 0.05). Publication bias and sensitivity analyses confirmed that the meta-analysis results were stable and reliable.

Conclusions

CYP2D6*10 polymorphisms influence the pharmacokinetics of tamoxifen in patients with breast cancer in Asia.

https://ift.tt/2z142j0