Evaluation of the Bonebridge BCI 602 active bone conductive implant in adults: efficacy and stability of audiological, surgical, and functional outcomes

xlomafota13 shared this article with you from Inoreader Evaluation of the Bonebridge BCI 602 active bone conductive implant in adults: efficacy and stability of audiological, surgical, and functional outcomes Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Feb 19. doi: 10.1007/s00405-022-07265-2. Online ahead of print. ABSTRACT PURPOSE: (1) To assess the effectiveness and safety of a bone-conduction implant, the Bonebridge BCI 602, in adults with conductive or mixed hearing loss. (2) To investigate whether the Bonebridge BCI 602 is at least as effective as the Bonebridge BCI 601 in such patients. METHODS: The study group included 42 adults who had either conductive or mixed hearing loss. All patients underwent Bonebridge BCI 602 implant surgery. Before and after implantation, pure-tone audiometry, speech recognition tests (in quiet and noise), and free-field audiometry were performed. Word recognition scores were evaluated using the Polish Monosyllabic Word Test. Speech reception thresholds in noise were assessed using the Polish Sentence Matrix Test. Subjective assessment of benefits was done using the APHAB (Abbreviated Profile of Hearing Aid Benef it) questionnaire. RESULTS: The APHAB questionnaire showed that difficulties in hearing decreased after BCI 602 implantation. Both word recognition in quiet and speech reception threshold in noise were significantly better after BCI 602 implantation and remained stable for at least 12 months. A significant advantage of the device is a reduced time for surgery while maintaining safety. In this study, the mean time for BCI 602 implantation was 28.3 min ± 9.4. CONCLUSIONS: The second-generation Bonebridge BCI 602 implant is an effective hearing rehabilitation device for patients with conductive or mixed hearing loss. Patient satisfaction and audiological results confirm its efficacy and safety. Its new shape and dimensions allow it to be used in patients previously excluded due to insufficient or difficult anatomical conditions. The new BCI 602 implant is as effective as its predecessor, the BCI 601. PMID:35182185 | DOI:10.1007/s00405-022-07265-2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Triazine-based porous organic polymers for reversible capture of iodine and utilization in antibacterial application

xlomafota13 shared this article with you from Inoreader Triazine-based porous organic polymers for reversible capture of iodine and utilization in antibacterial application Via radioactive iodine Sci Rep. 2022 Feb 16;12(1):2638. doi: 10.1038/s41598-022-06671-0. ABSTRACT The capture and safe storage of radioactive iodine (129I or 131I) are of a compelling significance in the generation of nuclear energy and waste storage. Because of their physiochemical properties, Porous Organic Polymers (POPs) are considered to be one of the most sought classes of materials for iodine capture and storage. Herein, we report on the preparation and characterization of tw o triazine-based, nitrogen-rich, porous organic polymers, NRPOP-1 (SABET = 519 m2 g-1) and NRPOP-2 (SABET = 456 m2 g-1), by reacting 1,3,5-triazine-2,4,6-triamine or 1,4-bis-(2,4-diamino-1,3,5-triazine)-benzene with thieno[2,3-b]thiophene-2,5-dicarboxaldehyde, respectively, and their use in the capture of volatile iodine. NRPOP-1 and NRPOP-2 showed a high adsorption capacity of iodine vapor with an uptake of up to 317 wt % at 80 °C and 1 bar and adequate recyclability. The NRPOPs were also capable of removing up to 87% of iodine from 300 mg L-1 iodine-cyclohexane solution. Furthermore, the iodine-loaded polymers, I2@NRPOP-1 and I2@NRPOP-2, displayed good antibacterial activity against Micrococcus luteus (ML), Escherichia coli (EC), and Pseudomonas aeruginosa (PSA). The synergic functionality of these novel polymers makes them promising materials to the environment and public health. PMID:35173259 | DOI:10.1038/s41598-022-06671-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Subclinical breast lymphedema as a possible risk of breast angiosarcoma

xlomafota13 shared this article with you from Inoreader Subclinical breast lymphedema as a possible risk of breast angiosarcoma Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Feb 2:S1748-6815(22)00049-3. doi: 10.1016/j.bjps.2022.01.041. Online ahead of print. NO ABSTRACT PMID:35172950 | DOI:10.1016/j.bjps.2022.01.041 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Leveraging Molecular Assays to Aid Decision-making in Large Indeterminate Thyroid Nodules

xlomafota13 shared this article with you from Inoreader Leveraging Molecular Assays to Aid Decision-making in Large Indeterminate Thyroid Nodules Via JAMA Otolaryngology–Head & Neck Surgery Online First To the Editor We read with great interest the recently published article by Dublin et al in JAMA Otolaryngology–Head & Neck Surgery, where it was shown that for indeterminate nodules larger than 4 cm, the positive-predictive value of a genomic classifier test (ThyroSeq) was 50% and the negative predictive value (NPV) was 89%. These values were noted to be improved relative to the test's performance on smaller nodules. The authors point out that the 2015 American Thyroid Association guidelines suggest that total thyroidectomy may be preferred for indeterminate nodules that are large (>4 cm) to limit completion thyroidectomy and conclude from their analysis that thyroid lobectomy may be sufficient for genomic classifier-negative indeterminate nodules. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Systematic construction and external validation of an immune‐related prognostic model for nasopharyngeal carcinoma

xlomafota13 shared this article with you from Inoreader Systematic construction and external validation of an immune‐related prognostic model for nasopharyngeal carcinoma Via Head & Neck Abstract Background We attempted to identify the most reliable immune-related index for predicting nasopharyngeal carcinoma (NPC) prognosis and to reveal its precise and integrated relationship with NPC progression. Method One thousand seven hundred and six patients with newly diagnosed NPC (1320 from the primary cohort and 386 from the validated cohort) from January 2010 to March 2014 were enrolled. Clinical features and 12 immune-related variables were analyzed. Results A high absolute lymphocyte count (ALC; >3.2 × 109/L) correlated with a poor prognosis of patients with NPC. Significant OS differences were discovered between patients with high ALC and no ALC elevation (p < 0.05, in primary cohort), showing similar prognostic risk to patients with advanced NPC (p > 0.05, in validated cohort). ALC improved the predictive performance of the basic tumor-node-metastasis prognostic model (p = 0.025), which was reliably validated in the external independent cohort. Conclusion High ALC is a surrogate marker for improved prognostic risk stratification in NPC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Immediate or interval abscess tonsillectomy? A systematic review and meta-analysis

xlomafota13 shared this article with you from Inoreader Immediate or interval abscess tonsillectomy? A systematic review and meta-analysis Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Feb 15. doi: 10.1007/s00405-022-07294-x. Online ahead of print. ABSTRACT OBJECTIVES: Peritonsillar abscess is a common complication of acute tonsillitis. However, no consensus has been reached yet on the optimal treatment of this condition. Therefore, this study aimed to compare clinical outcomes of immediate and interval abscess tonsillectomy. METHODS: The databases of PubMed, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for completed studies published until the 1st of November 2021. Comparative studies assessing intraoperative and postoperative outcomes of immediate and interval abscess tonsillectomy were considered, with the primary outcome being postoperative hemorrhage. Operative time, intraoperative blood loss, postoperative pain, and duration of hospital stay were classed as secondary outcomes. A random-effects pairwise meta-analysis of both randomized a nd non-randomized trials was conducted. Subgroup analysis linked to the randomization of trials was executed. Quality assessment was performed, utilizing the Cochrane risk of bias tool and ROBINS-I tool for randomized and non-randomized trials, respectively. RESULTS: Data from 265 cases stemming from six trials were pooled together. For postoperative bleeding rates, no statistically significant difference between immediate and interval tonsillectomy was detected (OR = 1.26; 95% CI 0.27, 5.86; p = 0.77). By contrast, longer hospital stay was observed for patients subjected to interval tonsillectomy (SMD = - 0.78; CI - 1.39 to- 0.17; p = 0.01). For operative time and intraoperative blood loss, no statistically significant difference was noticed between immediate and interval tonsillectomy (SMD = 1.10; 95% CI - 0.13, 2.33; p = 0.08; and SMD = 0.04; 95% CI - 0.49, 0.57; p = 0.88; respectively). CONCLUSIONS: This study shows that quinsy tonsillectomy appears to be a safe meth od, providing full abscess drainage and instant relief of the symptoms. Moreover, quinsy tonsillectomy was not associated with a statistically higher postoperative hemorrhage incidence rate than immediate tonsillectomy. PMID:35169892 | DOI:10.1007/s00405-022-07294-x View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Vax1 rs7078160 polymorphisms and non-syndromic cleft lip

xlomafota13 shared this article with you from Inoreader Vax1 rs7078160 polymorphisms and non-syndromic cleft lip: correspondence Via Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial Braz J Otorhinolaryngol. 2022 Jan 29:S1808-8694(22)00003-9. doi: 10.1016/j.bjorl.2022.01.002. Online ahead of print. NO ABSTRACT PMID:35168926 | DOI:10.1016/j.bjorl.2022.01.002 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Early death in supraglottic laryngeal squamous cell carcinoma: A population-based study

xlomafota13 shared this article with you from Inoreader Early death in supraglottic laryngeal squamous cell carcinoma: A population-based study Via ear nose throat Ear Nose Throat J. 2022 Feb 16:1455613221078184. doi: 10.1177/01455613221078184. Online ahead of print. ABSTRACT BACKGROUND: Supraglottic laryngeal squamous cell carcinoma (LSCC) is the second most common type of laryngeal cancer with a poor prognosis. Current population-based estimates of the early death rate and associated factors for early death of supraglottic LSCC are lacking. The purpose of this study was to assess the early death rate and related factors for early dea th in patients with supraglottic LSCC. METHODS: We identified 3733 adult patients diagnosed with supraglottic LSCC between 2010 and 2017 for whom the vital status at 3 months was known from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were staged according to the seventh edition of the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging system. The early death (survival time ≤ 3 months) rate was calculated. Univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with the early death rate. RESULTS: 313 (8.38%) of the 3733 patients died within 3 months of diagnosis of supraglottic LSCC. Of these, 225 patients died from cancer-specific causes. Multivariate logistic regression analyses confirmed that advanced age, male sex, advanced T stage, advanced N stage, advanced M stage, and not undergoing treatment (surgery, radiotherapy, and chemotherapy) had significant c orrelations with all-cause early death in supraglottic LSCC. In addition, advanced age, advanced T stage, advanced N stage, advanced M stage, and not undergoing treatment (surgery, radiotherapy, and chemotherapy) were significantly correlated with cancer specificity in supraglottic LSCC. CONCLUSION: When a tumor is newly diagnosed, we should pay close attention to sex, age, unmarried status and AJCC TNM staging to quickly detect supraglottic LSCC patients with a tendency toward early death. These findings have implications for precise prognosis prediction and individualized and personalized patient counseling and therapy. PMID:35171058 | DOI:10.1177/01455613221078184 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Bilateral Pulsatile Tinnitus Caused by Bilateral Dilated Mastoid Emissary Vein

xlomafota13 shared this article with you from Inoreader Bilateral Pulsatile Tinnitus Caused by Bilateral Dilated Mastoid Emissary Vein Via ear nose throat Ear Nose Throat J. 2022 Feb 16:1455613221077597. doi: 10.1177/01455613221077597. Online ahead of print. ABSTRACT Pulsatile tinnitus is a rhythmic type of tinnitus. Most cases are caused by vascular disorders and present as synchronous with the patient's heartbeat. A dilated mastoid emissary vein may cause pulsatile tinnitus. Here, we report the first case of bilateral pulsatile tinnitus caused by dilated bilateral mastoid emissary vein. The patient suffered from bilateral pu lsatile tinnitus for 2 years. His bilateral tinnitus disappeared temporarily when the bilateral mastoid processes were compressed. Temporal bone computed tomographic (CT) showed the bilateral dilated mastoid emissary canals. Cranial Magnetic resonance venograms (MRV) showed the bilateral dilated mastoid emissary veins. We explained the risk of surgery to the patient. Because the patient could tolerate his tinnitus and did not have a hemangioma or tumor, he did not choose to undergo surgery. PMID:35171065 | DOI:10.1177/01455613221077597 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

How to Maximize the Outcomes of Cochlear Implantation in Common Cavity and Cochlear Aplasia With Dilated Vestibule, the Most Severe Inner Ear Anomalies?

xlomafota13 shared this article with you from Inoreader How to Maximize the Outcomes of Cochlear Implantation in Common Cavity and Cochlear Aplasia With Dilated Vestibule, the Most Severe Inner Ear Anomalies? Via pubmed: "clin exp otorhinola... Clin Exp Otorhinolaryngol. 2022 Feb 15. doi: 10.21053/ceo.2022.00164. Online ahead of print. NO ABSTRACT PMID:35158419 | DOI:10.21053/ceo.2022.00164 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Secondary primary malignancy in patients with head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools Via Head and neck squamous cell carcinoma by Shih-Wei Wang, Leong-Perng Chan, Ling-Feng Wang, Che-Wei Wu, Sheng-Hsuan Lin, Tzu-Yen Huang, Ka-Wo Lee Background The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) showed no significant improvement for decades, however, the impact of advances in diagnostic tools is rarely mentioned. This study investigated the clinical characteristic of HNSCC with SPM over a 27-year period especially from the perspective of diagnostic tools. Methods This study evaluated 157 HNSCC patients with SPM. The patients were divided into two groups according to the time of SPM diagnosis (Group A:1992–2003; Group B: 2004–2014). Age, gender, stage of first primary malignancy (FPM), SPM interval, overall survival, and disease-free survival were compared between groups. Results Group B had significantly more SPM developed rate (p = 0.002), more SPM patients with advanced stage of FPM (p = 0.001), synchronous SPM (p = 0.006), and shorter SPM interval (p Conclusion Among patients diagnosed with HNSCC recently, more SPMs are diagnosed in a shorter time interval and in a more advanced stage. The overall advances in diagnostic tools cannot significantly improve SPM survival, however, it enables more patients to receive corresponding treatment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Predisposition to and Prognosis of Thyroid Cancer May Not Be Affected by Graves’ Disease, But Some Questions Still Remain

xlomafota13 shared this article with you from Inoreader Predisposition to and Prognosis of Thyroid Cancer May Not Be Affected by Graves' Disease, But Some Questions Still Remain Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 2, Page 59-62, February 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.