Bone targeted new zoledronate derivative: design, synthesis, 99mTc-coupling, in-silico study and preclinical evaluation for promising osteosarcoma therapy

alexandrossfakianakis shared this article with you from Inoreader Bone targeted new zoledronate derivative: design, synthesis, 99mTc-coupling, in-silico study and preclinical evaluation for promising osteosarcoma therapy via International Journal of Radiation Biology: Table of Contents: Taylor and Francis . View on Web

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Possible mechanisms and biomarkers of resistance to vismodegib in SHH medulloblastoma

alexandrossfakianakis shared this article with you from Inoreader Possible mechanisms and biomarkers of resistance to vismodegib in SHH medulloblastoma via Neuro-Oncology Advance Access National Council for Scientific and Technological Development10.13039/501100003593305647/2019-9201001/2014-4Children's Cancer InstituteWilliam Donald Nash Brain Tumour Research FellowshipBrain Tumour Foundation of Canada10.13039/501100000238Swifty Foundation10.13039/100017296North West Cancer Research10.13039/501100000357 View on Web

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Analysis of fractured dental implant body from five different implant systems: a long-term retrospective study

alexandrossfakianakis shared this article with you from Inoreader Analysis of fractured dental implant body from five different implant systems: a long-term retrospective study via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The aim of this study was to perform an analysis of the incidence of implant body fracture and to identify possible risk factors. A long-term follow-up retrospective evaluation of 3477 patients who received 8588 implants from five implant systems was performed. Overall, 2810 patients who received 7502 implants, with an average follow-up of 6.9 years, were included in the analysis. The overall body fracture rate was 0.49% (37/7502), among which 32.4% (12/37) were implants with a reduced diameter. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Evaluation of Lipocalin-2 and Twist expression in thyroid cancers and its relationship with epithelial mesenchymal transition

alexandrossfakianakis shared this article with you from Inoreader Evaluation of Lipocalin-2 and Twist expression in thyroid cancers and its relationship with epithelial mesenchymal transition Via Annals of Diagnostic Pathology Publication date: Available online 10 May 2022 Source: Annals of Diagnostic Pathology Author(s): Pınar Celepli, İrem Bigat, Sefika Karabulut, Salih Celepli, Sema Hücümenoğlu View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Alpha variant coronavirus outbreak in a nursing home despite high vaccination coverage: molecular, epidemiological and immunological studies

alexandrossfakianakis shared this article with you from Inoreader Alpha variant coronavirus outbreak in a nursing home despite high vaccination coverage: molecular, epidemiological and immunological studies Via Clinical Infectious Diseases Advance Access Abstract Background Vaccination may control the COVID-19 pandemic, including in nursing homes where many high-risk people live. We conducted extensive outbreak investigations. Methods We studied an outbreak at a nursing home in Switzerland where vaccination uptake of mRNA vaccines against SARS-CoV-2 was 82% among residents as of Jan 21/2021. After a vaccinated symptomatic HCW was diagnosed with COVID-19 on Feb 22, we did an outbreak investigations in house A (47 residents, 37 HCWs) using SARS-CoV-2-specific PCR in nasopharyngeal swabs. We performed whole-genome sequencing of SARS-CoV-2 and serological analyses. Results We identified 17 individuals with positive PCR tests; ten residents (five vaccinated) and seven HCWs (three vaccinated). Median age among residents was 86 years (interquartile range [IQR] 70-90) and 49 years (IQR 29-59) among HCWs. Among the five vaccinated residents, 60% had mild disease and had 40% no symptoms, whereas all five unvaccinated residents had mild to severe disease and two died. The vaccine effectiveness for the prevention of infection among the residents was 73.0% (95% Cl 24.7-90.1). The 12 available genomes were all alpha variants. Neutralizing titers were significantly higher in vaccinated individuals upon re-exposure (>1 week after diagnosis) than in vaccinated, unexposed HCWs (p=0.012). Transmission networks indicated four likely or possible transmissions from vaccinated to other individuals, and 12 transmission events from unvaccinated individuals. Conclusions COVID-19 outbreaks can occur in nursing homes, including transmission from vaccinated persons to others. Outbreaks might occur silently, underlining the need for continued testing and basic infection control measures in these high-risk settings. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Does a combination of self‐reported signs related to central sensitization and pressure pain threshold allow for a more detailed classification of pain‐related characteristics in patients with chronic musculoskeletal pain?: A cross‐sectional study

alexandrossfakianakis shared this article with you from Inoreader Does a combination of self‐reported signs related to central sensitization and pressure pain threshold allow for a more detailed classification of pain‐related characteristics in patients with chronic musculoskeletal pain?: A cross‐sectional study Via Pain Practice Abstract Objectives The clinical utility of combining the central sensitization (CS) inventory (CSI) with the pressure pain threshold (PPT) in assessing the effect of central sensitization on pain is unknown. This study aimed to investigate (1) the effects of CSI, PPT, and their interaction on pain and (2) the characteristics of clinical symptoms in patients with chronic musculoskeletal pain grouped according to the CSI score and PPT value. Method A total of 187 participants with chronic musculoskeletal pain were recruited. PPT, brief pain inventory, widespread pain index, pain-catastrophizing scale, EuroQol-5 dimension, and CSI were assessed. Multiple regression analyses were performed using pain intensity and interference scores as dependent variables and the CSI score and PPT value as independent variables. Hierarchical cluster analysis was also performed to classify the participants into subgroups according to the CSI score and PPT value. Following the classification, pain-related characteristics and health-related QOL were compared among the subgroups. Results Multiple regression analyses demonstrated that only the CSI score significantly affected pain intensity and interference. As a result of the cluster analysis, three groups were identified: cluster 1 (n = 61, CSI low/PPT low group), cluster 2 (n = 78, CSI low/PPT high group), and cluster 3 (n = 48, CSI high/PPT low group). The CSI high/PPT low group had higher incidence of pain-related symptoms than the CSI low groups regardless of the PPT value. Conclusions Combined CSI and PPT may not fully allow a detailed classification of pain-related characteristics. The CSI may be clinically more useful for assessing the effect of CS on pain-related symptoms. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Influence of lingual plate fracture pattern on remodelling site during the healing process of sagittal split ramus osteotomy

alexandrossfakianakis shared this article with you from Inoreader Influence of lingual plate fracture pattern on remodelling site during the healing process of sagittal split ramus osteotomy Via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The purpose of this study was to investigate whether differences in the pattern of the lingual plate split in sagittal split ramus osteotomy (SSRO) affect the remodelling of the split site. Sixty-one patients with mandibular prognathism (122 sides) underwent SSRO. Computed tomography (CT) was performed at 1 week and 1 year after SSRO. Bone splits were classified according to the lingual split scale (LSS) and the lateral bone cut end (LBCE) by evaluating CT images at 1 week. The remodelling at the split sites was evaluated by superimposing the CT images obtained at 1 week and 1 year. (Source: International Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Perceptions of NZ orthodontists and periodontists on the management of gingival recession in orthodontic patients

alexandrossfakianakis shared this article with you from Inoreader Perceptions of NZ orthodontists and periodontists on the management of gingival recession in orthodontic patients Via Australian Dental Journal ABSTRACT Background This study aimed to investigate the perceptions and opinions of orthodontists and periodontists on the management of gingival recession in orthodontic patients. Methods An online survey was sent to 29 periodontists and 80 orthodontists registered and currently practising in New Zealand. All participants answered questions about the timing and clinical indications of mucogingival surgeries in orthodontic patients diagnosed with mucogingival deformities. Results Most periodontists and orthodontists believed that gingival grafts should ideally be performed after orthodontic treatment. In clinical practice, 40% of periodontists indicated that they would receive referrals after completion of orthodontic treatment. However, 29.6% of orthodontists indicated that they would refer to a periodontist before orthodontic treatment in clinical practice. The most crucial factor that affected periodontists' decision making was 'evidence-based guidelines' (35.0%), followed by 'clinical experience' (30.0%) and 'patient concerns' (15.0%). All four factors of 'gingival phenotype', 'presence of gingival recession', 'amount of keratinised tissue' and 'planning specific tooth movements' were equally considered by orthodontists regarding their decision-making. Conclusions The majority of the surveyed New Zealand periodontists and orthodontists expressed a belief that the ideal timing for the management of gingival recessions would be after the completion of orthodontic treatment. © 2022 Australian Dental Association. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Identification of non-synonymous variations in ROBO1 and GATA5 genes in a family with bicuspid aortic valve disease

alexandrossfakianakis shared this article with you from Inoreader Identification of non-synonymous variations in <i>ROBO1</i> and <i>GATA5</i> genes in a family with bicuspid aortic valve disease Via Journal of Human Genetics - Issue - nature.com science feeds Journal of Human Genetics, Published online: 09 May 2022; doi:10.1038/s10038-022-01036-x Identification of non-synonymous variations in ROBO1 and GATA5 genes in a family with bicuspid aortic valve disease View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics

alexandrossfakianakis shared this article with you from Inoreader Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics Via Journal of Human Genetics - Issue - nature.com science feeds Journal of Human Genetics, Published online: 09 May 2022; doi:10.1038/s10038-022-01040-1 Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Synergistic antibacterial effects of low-intensity ultrasound and peptide LCMHC against Staphylococcus aureus

alexandrossfakianakis shared this article with you from Inoreader Synergistic antibacterial effects of low-intensity ultrasound and peptide LCMHC against <em>Staphylococcus aureus</em> Via ScienceDirect Publication: International Journal of Food Microbiology Publication date: Available online 9 May 2022 Source: International Journal of Food Microbiology Author(s): Zijin Yuan, Jude Juventus Aweya, Jian Li, Zhongyan Wang, Shiying Huang, Mingjing Zheng, Linfan Shi, Shanggui Deng, Shen Yang View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Particulate matter (PM10) induces in vitro activation of human neutrophils, and lung histopathological alterations in a mouse model

alexandrossfakianakis shared this article with you from Inoreader Particulate matter (PM10) induces in vitro activation of human neutrophils, and lung histopathological alterations in a mouse model Via Earth and environmental sciences : nature.com subject feeds View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.