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Παρασκευή 9 Σεπτεμβρίου 2016

Pharmacokinetics and pharmacodynamics of albuterol multidose dry powder inhaler and albuterol hydrofluoroalkane in children with asthma



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MP-AzeFlu provides rapid and effective allergic rhinitis control in real life: A pan-European study



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Assessment of anti-inflammatory effect from addition of a long-acting beta-2 agonist to inhaled corticosteroid



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The clinical and laboratory characteristics of acute spontaneous urticaria and its progression to chronic spontaneous urticaria



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Safety profile of oral immunotherapy with cow‘s milk and hen egg: A 10-year experience in controlled trials



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Effect of educational and electronic medical record interventions on food allergy management



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Anxiety and depression in adults with primary immunodeficiency: How much do these patients experience and how much do they attribute to their primary immunodeficiency?



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For the Patient



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Abstracts form the Eastern Allergy Conference: June 2‐5, 2016 ∼ Palm Beach, Florida



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Circumflex scapular vessels: A rescue strategy in case of internal mammary anastomosis failure

We read with great interest O'Neill et al.'s paper titled 'Usability of the internal mammary recipient vessels in microvascular breast reconstruction.'1. We agree with their conclusion regarding the reliability of internal mammary recipient vessels.

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Underlying Reasons and Timing Associated with Readmission Following Plastic Surgery: Analysis of a National Surgical Database

Post-operative readmission has become increasingly emphasized as a measure of healthcare quality, and as such numerous studies have attempted to benchmark readmission rates and identify risk factors for such events.1,2 However, no study to date has fully evaluated the underlying reasons for readmissions in plastic surgery. In 2012, the American College of Surgeon's National Surgical Quality Improvement Program (NSQIP) registry began collecting data on the primary reason for within 30-day post-operative readmissions.

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Clinical Coding and External Causes of Injury: The Importance of Documentation

Injuries are a prominent cause of morbidity globally. In the United Kingdom (UK) alone, there were over 500,000 emergency hospital admissions for injuries within 2014/15.1 Causes of injury are captured in the clinical coding of hospital activity and this data underpins national datasets such as Hospital Episode Statistics (HES). Knowing the context of an injury permits individualised patient care and this information is crucial for surveillance, intervention evaluation and policy creation.2,3 Monitoring patterns in assaults, unintentional injuries and self-inflicted trauma can lead to the creation of injury-prevention programmes which could help reduce the volumes of avoidable hospital admissions.

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Selection of recipient vessels for free flap following intra-arterial chemoradiotherapy

Many centers currently combine intra-arterial chemotherapy and concomitant radiotherapy for treating head and neck cancer with favorable results. However, some patients develop recurrent, residual disease/complications after completing treatment protocols requiring free-flap surgery. The feasibility of microsurgery following intra-arterial chemoradiotherapy remains unclear.

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Surgical anatomy of the first extensor compartment: A systematic review and comparison of normal cadavers vs. De Quervain syndrome patients

De Quervain syndrome or tenosynovitis is a common wrist pathology caused by stenosing tenosynovitis of the first dorsal compartment. Multiple studies have demonstrated significant anatomic variation within the first extensor compartment.

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Adipofascial Fold-Down Flaps Based on the Posterior Tibial Artery Perforator to Cover the Medial Foot and Ankle Defects

We are to report the clinical result after coverage for soft tissue defect on the medial foot and ankle with adipofascial fold-down flap based on the posterior tibial artery perforator branch proximal to the defect.

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The Relationships of Comorbidities and Old Age with Postoperative Complications of Head and Neck Free Flaps: A Review

The aim of this paper was to characterize the relationships between free flap complications and old age or comorbidities. In a PubMed and Scopus search, the search terms "1) free flap OR microvascular anastomosis AND 2) elderly OR old age AND 3) complications OR comorbidity OR co-morbidity" were used. Among the 62 full texts from 241 abstracts, 31 papers without sufficient content were excluded and 11 mined papers were added. Thereafter, 42 papers were reviewed.Overall complication rates increased significantly with age (p<0.001; y=0.457x+13.464; 40.9% at 60 years, 45.5% at 70 years, and 50.0% at 80 years).

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Development of decellularization method for producing nerve allografts using less invasive detergents and hyper/hypotonic solutions

A novel means of processing decellularized nerve grafts using osmotic effects of hypotonic and hypertonic solutions and Triton X-100 (a nonionic detergent) and CHAPS (an amphoteric detergent) is described.

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Modifying the GoPro Hero 4 for recording High Definition video in the operating room

Video capturing procedures in the operating room is becoming increasingly more popular and recordings can be used for teaching, presentation at conferences and courses and for surgical technique analysis 1,2 as well as potentially becoming a medico-legal record. Specialised surgical cameras exist but these are expensive with limited resolutions. There are many relatively inexpensive commercially available high-resolution action cameras which can be modified to provide very high definition video recordings in the operating room.

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Are disseminated tumor cells in bone marrow and tumor-stroma ratio clinically applicable for patients undergoing surgical resection of primary colorectal cancer? The Leiden MRD study

Abstract

Purpose

Current TNM staging does not appropriately identify high-risk colorectal cancer (CRC) patients. The aim of this study was to evaluate whether the presence of disseminated tumor cells (DTCs) in the bone marrow (BM) and the presence of stroma in the primary tumor, i.e., the tumor-stroma ratio (TSR), in patients undergoing surgical resection of primary CRC provides information relevant for disease outcome.

Methods

Patients with primary CRC (n = 125), consecutively admitted for curative resection between 2001 and 2007, were included in the study. All patients underwent BM aspiration before surgery. Detection of tumor cells was performed using immunocytochemical staining for cytokeratin (CK-ICC). The TSR was determined on diagnostic H&E stained sections of primary tumors.

Results

DTCs were detected in the BM of 23/125 patients (18 %). No association was found between BM status and overall survival (HR 0.97 (95 % CI 0.45–2.09), p = 0.93). Also, no significant difference was found in their 5-year survival rate (resp. 72 % and 68 % for BM-positive versus BM-negative patients). The TSR was found to be associated with a worse overall survival (HR 2.16, 95 % CI 1.02–4.57, p = 0.04) with 5-year survival rates of 84 % versus 62 % for stroma-low and stroma-high patients, respectively. No relation was found between the presence of DTCs and TSR.

Conclusions

Our data indicate that the presence of DTCs in the BM of CRC patients is not associated with disease outcome. The TSR was, however, found to be associated with a worse overall survival, which indicates that for CRC the tumor microenvironment plays an important role in its behavior and prognosis.



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Epicardial fat is a negative predictor of spine volumetric bone mineral density and trabecular bone score in acromegaly



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