Inhibitory effects of Saussurea involucrata (Kar. et Kir.) Sch. -Bip. on adjuvant arthritis in rats

Publication date: 24 December 2016
Source:Journal of Ethnopharmacology, Volume 194
Author(s): Xiaoli Han, Dan Su, Xiaoyan Xian, Mingyang Zhou, Xianzhe Li, Jian Huang, Jinhui Wang, Huiyuan Gao
Ethnopharmacological relevanceSaussurea involucrate (Kar. et Kir.) Sch. -Bip is an endangered species of the Compositae family, and this species has long been used for the treatment of rheumatoid arthritis, dysmenorrhea, stomachache, and altitude sickness in Uighur folk and Chinese medicine.Aim of the studyThis study aimed to investigate the different therapeutic efficacy of alcohol infusion (SEI) and water decoction (SWD) of S. involucrata in treating rheumatoid arthritis using complete Freund's adjuvant (CFA)-induced arthritis (AA) in a rat model.Materials and methodsMale Wistar rats (160–180g) were immunized by intradermal injection of 0.1mL of CFA into the left hind metatarsal footpad. Aspirin was chosen as the positive drug. Alcohol infusion (SEI, 400 and 800mg/kg) and water decoction (SWD, 443 and 886mg/kg) of S. involucrata aerial parts were orally administered from day 1 and continued for 21 days. Arthritis severity was evaluated by arthritic score, body weight loss, and paw swelling. The levels of TNF-α, IL-β, and IL-6 in the serum of AA rats were detected by enzyme linked immunosorbent assay (ELISA). Histological changes in the ankle joint were also analyzed in the AA rats.ResultsBoth SEI and SWD significantly ameliorated AA severity, as suggested by the modulatory effects on body weight loss, paw swelling, and arthritic score. Histopathological improvement in the joint architecture was also observed in the SEI- and SWD-treated AA rats. The overproduction of TNF-α, IL-1β, and IL-6 was remarkably attenuated in the serum of all treated rats. Furthermore, the therapeutic effect of SWD was more potent than that of SEI in treating rheumatoid arthritis using AA in a rat model, which was reported for the first time.ConclusionsThese results suggested that the extract of S. involucrata significantly attenuated adjuvant arthritis in rats by decreasing the levels of TNF-α, IL-1β, and IL-6 in the serum. S. involucrata has the potential to be regarded as a candidate for the treatment of human arthritis. Moreover, the therapeutic effect of SWD was much better than alcohol infusion, indicting that active constituents are mainly in the water extract, which is helpful for the clinical treatments to choose the appropriate process.

Graphical abstract

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(3′R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells

Publication date: 24 December 2016
Source:Journal of Ethnopharmacology, Volume 194
Author(s): Angela Paterna, Sofia E. Gomes, Pedro M. Borralho, Silva Mulhovo, Cecília M.P. Rodrigues, Maria-José U. Ferreira
Ethnopharmacological relevanceTabernaemontana elegans Stapf. (Apocynaceae) is a medicinal plant traditionally used in African countries to treat cancer.Aims of the studyTo discover new apoptosis inducing lead compounds from T. elegans and provide scientific validation of the ethnopharmacological use of this plant.Materials and methodsThrough fractionation, (3′R)-hydroxytaberanelegantine C (1), a vobasinyl-iboga bisindole alkaloid, was isolated from a cytotoxic alkaloid fraction of the methanol extract of T. elegans roots. Its structure was identified by spectroscopic methods, mainly 1D and 2D NMR experiments. Compound 1 was evaluated for its ability to induce apoptosis in HCT116 and SW620 colon and HepG2 liver carcinoma cells. The cell viability of compound 1 was evaluated by the MTS and lactate dehydrogenase (LDH) assays. Induction of apoptosis was analyzed through Guava ViaCount assay, by flow cytometry, caspase-3/7 activity assays and evaluation of nuclear morphology by Hoechst staining. To determine the molecular pathways elicited by 1 exposure, immunoblot analysis was also performed.Results(3′R)-hydroxytaberanelegantine C (1) displayed strong apoptosis induction activity as compared to 5-fluorouracil (5-FU), the most used anticancer agent in colorectal cancer treatment. In the MTS assay, compound 1 exhibited IC50 values similar or lower than 5-FU in the three cell lines tested. The IC50 value of 1 was also calculated in CCD18co normal human colon fibroblasts. The lactate dehydrogenase assay showed increased LDH release by compound 1, and the Guava ViaCount assay revealed that 1 significantly increased the incidence of apoptosis to a further extent than 5-FU. Moreover, the induction of apoptosis was corroborated by evaluation of nuclear morphology by Hoechst staining and caspase-3/7 activity assays of 1 treated cells. As expected, in immunoblot analysis, compound 1 treatment led to poly(ADP-ribose) polymerase cleavage. This was accompanied by decreased anti-apoptotic proteins Bcl-2 and XIAP steady state levels in all three cancer cell lines tested.ConclusionsCompound 1 showed remarkable induction of apoptosis in HCT116, SW620 and HepG2 cells. Together, the results suggest that compound 1 is a promising lead structure for inducing apoptosis.

Graphical abstract

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Evidence that activation of nuclear peroxisome proliferator-activated receptor alpha (PPARα) modulates sleep homeostasis in rats

Publication date: Available online 16 September 2016
Source:Brain Research Bulletin
Author(s): Eric Murillo-Rodríguez, Khalil Guzmán, Gloria Arankowsky-Sandoval, Mireille Salas-Crisóstomo, Ramsés Jiménez-Moreno, Oscar Arias-Carrión
The peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor superfamily that has been suggested as a modulator of several physiological functions. The PPARα recognizes as an endogenous ligand the anorexic lipid mediator oleoylethanolamide (OEA) which displays wake-inducing properties. Despite that recent evidence indicates that activation of PPARα by synthetic agonists such as Wy14643 enhances waking as well as the extracellular contents of wake-related neurotransmitters, the role of PPARα in sleep recovery after prolonged waking has not been fully described. Thus, the aim of this study was to characterize if PPARα regulates sleep rebound after total sleep deprivation (TSD). We report that after 6h of TSD activation of PPARα by pharmacological systemic administration of OEA (10, 20 or 30mg/Kg, i.p.) promoted alertness by blocking the sleep rebound after TSD. Besides, wake-linked compounds such as dopamine, norepinephrine, serotonin, or adenosine collected from nucleus accumbens were enhanced after TSD in OEA-treated animals. These sleep and neurochemical results were mimicked after injection of PPARα agonist Wy14643 (10, 20, 30mg/Kg, i.p.). However, similar findings from the sham of vehicle groups were observed if PPARα antagonist MK-886 was administered to rats (10, 20, 30mg/Kg, i.p.). Our results strengthened the hypothesis that PPARα might modulate sleep and neurochemical homeostasis after sleep deprivation.

Graphical abstract

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Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats

Publication date: Available online 16 September 2016
Source:Brain Research Bulletin
Author(s): Jing Yuan, Aihua Wang, Yan He, Zhihua Si, Shan Xu, Shanchao Zhang, Kun Wang, Dawei Wang, Yiming Liu
Loss of blood-brain barrier (BBB) integrity is a downstream event caused by traumatic brain injury (TBI). BBB integrity is affected by certain physiological conditions, including inflammation and oxidative stress. Cordycepin is a susbtance with anti-inflammatory and anti-oxidative effects. Therefore, it is necessary to investigate whether cordycepin affects TBI-induced impairments of BBB integrity. Using TBI rats as the in vivo model and applying multiple techniques, including stroke severity evaluation, Evans blue assessment, quantitative real-time PCR, Western blotting and ELISA, we investigated the dose-dependent protective effects of cordycepin on the TBI-induced impairments of BBB integrity. Cordycepin treatment attenuated the TBI-induced impairments in a dose-dependent manner, and played a role in protecting BBB integrity. Cordycepin was able to alleviate TBI-induced loss of tight junction proteins zonula occludens protein-1 (ZO-1) and occludin, which are important for BBB integrity. Moreover, cordycepin suppressed pro-inflammatory factors, including IL-1β, iNOS, MPO and MMP-9, and promoted anti-inflammation-associated factors arginase 1 and IL-10. Furthermore, cordycepin inhibited NADPH oxidase (NOX) expression and activity following TBI, probably through NOX1, but not NOX2 and NOX4. Cordycepin has protective effects against brain damages induced by TBI. The protection of cordycepin on BBB integrity was probably achieved through recovery of tight junction proteins, inhibition of local inflammation, and prevention of NOX activity.



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Suppressor of cytokine signaling 2 (SOCS2) contributes to encephalitis in a model of Herpes infection in mice

Publication date: Available online 16 September 2016
Source:Brain Research Bulletin
Author(s): Larissa Fonseca da Cunha Sousa, Milene Alvarenga Rachid, Graciela Kunrath Lima, Aline Silva de Miranda, Márcia de Carvalho Vilela, Norinne Lacerda Queiroz, David Henrique Rodrigues, Marco Antonio Campos, Erna Geessien Kroon, Fabiana Simão Machado, Antônio Lúcio Teixeira
The most severe manifestation of Herpes Simplex Type 1 virus (HSV-1) infection is encephalitis characterized by arousal impairment and seizures that can evolve to coma and death. Previous studies reported the involvement of suppressor of cytokine signaling (SOCS) proteins, specifically SOCS1 and SOCS3, in HSV-1 infection, suggesting that other members of this family could be involved in the immune response against HSV-1. No previous study has reported the role of SOCS2 in HSV-1 infection. In the current study, C57BL/6 wild-type mice (WT) and mice deficient in SOCS2 gene (SOCS2^−/−) were subjected to intracranial inoculation with 10² plaque forming units (PFU) of HSV-1. Survival curve, neuroinflammatory parameters and neuropathology were evaluated. Infected SOCS2^−/− mice had increased survival in comparison with infected WT animals. This better outcome was associated with reduced leukocyte infiltration, concentration of cytokines, and structural changes in the brain. SOCS2 seems to play a detrimental role in HSV-1 encephalitis. Moreover, the control of neuroinflammatory response in HSV-1 infection was of paramount importance to clinical outcome.



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Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1(TRPA1) expression via activation of HIF1αin A549 cells

Publication date: October 2016
Source:Free Radical Biology and Medicine, Volume 99
Author(s): Yichu Nie, Chuqin Huang, Shan Zhong, Michael A. Wortley, Yulong Luo, Wei Luo, Yanqing Xie, Kefang Lai, Nanshan Zhong
We previously found that transient receptor potential ankyrin 1 (TRPA1) in guinea pig tracheal epithelial cells was elevated after 14 days of cigarette smoke (CS) exposure. However, the mechanism underlying CS-induced TRPA1 expression remains unknown. Here, we explored whether cigarette smoke extract (CSE)-induced TRPA1 expression is related with modulation of HIF1α in A549 cells. Our results showed that CSE increased TRPA1 expression in A549 cells, decreased Iκ B, PHD2, and HDAC2, and increased ROS release and nuclear translocation of NF-κ B and HIF1α. Moreover, HIF1α siRNA and/or MG132 (a proteasome inhibitor) pretreatment significantly inhibited CSE-induced TRPA1 expression and HIF1α nuclear translocation in A549 cells. However, HIF1α siRNA pretreatment did not affect CSE-induced NF-κ B nuclear translocation, suggesting that CSE-induced TRPA1 expression in A549 cells is directly mediated by HIF1α, but not by NF-κ B. Similar to CSE treatment, treatment of A549 cells with LPS caused significant increases in nuclear translocation of NF-κ B and HIF1α mRNA expression, but did not alter TRPA1 mRNA expression. However, pretreatment with PHD2 siRNA did result in increased TRPA1 mRNA expression in LPS-treated A549 cells; an effect that was inhibited by SN50 (a NF-κ B inhibitor). It suggests a role for NF-κ B to indirectly regulate TRPA1 mRNA expression via modulating HIF1α mRNA transcription. In addition, treatment cells with HDAC2 siRNA plus 2%CSE resulted in increased HIF1α nuclear translocation and TRPA1 expression, which was significantly inhibited by MG132 and HIF1α siRNA. These results suggest that HDAC2 indirectly modulates TRPA1 expression by promoting the DNA-binding activity of HIF1α. These findings show that CSE increases TRPA1 expression in airway epithelial cells by directly activating HIF1α, and that this increase in TRPA1 expression is indirectly regulated via NF-κ B, PHD2 and HDAC2 modulation of HIF1α activity.

Graphical abstract

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Mentoring and Modeling Professionalism: Clinical Care

No abstract available

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Scholar : These new articles for Body, Movement and Dance in Psychotherapy are available online

The online platform for Taylor & Francis Online content New for Body, Movement and Dance in Psychotherapy and online now on Taylor & Francis Online: Original Articles Utilising dreambody choreutics to integrate somatics with lucid dream criteria Lauren Garrett Pages: 1-14 | DOI: 10.1080/17432979.2016.1231134 Routledge Psychoanalysis Like the Facebook Page for the latest Psychoanalysis news and offers. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for African Journal of Marine Science are available online

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The online platform for Taylor & Francis Online content New for African Journal of Marine Science and online now on Taylor & Francis Online: Online First Articles Etmopterus alphus n. sp.: a new lanternshark (Squaliformes: Etmopteridae) from the south-western Indian Ocean DA Ebert, N Straube, RW Leslie & S Weigmann Pages: 1-12 | DOI: 10.2989/1814232X.2016.1198275 Sharks caught in the KwaZulu-Natal bather protection programme, South Africa. 13. The tiger shark Galeocerdo cuvier ML Dicken, G Cliff & H Winker Pages: 1-17 | DOI: 10.2989/1814232X.2016.1198276 Explore the latest free access research relating to Sustainable Development Goal 15: Life on Land This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Annals of GIS are available online

The online platform for Taylor & Francis Online content New for Annals of GIS and online now on Taylor & Francis Online: Original Articles An intelligent deployment method of geo-sensor networks in 3D environment Alireza Chehreghan, Mahmoodreza Delavar & Reza Zarei Pages: 1-15 | DOI: 10.1080/19475683.2016.1231716 How has social media affected Engineering, Computer Science & Technology? Find out with our Social Media Research collection now available with free access! This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Hémangiomes congénitaux : encore une implication des protéines G !

Publication date: Available online 15 September 2016
Source:Annales de Dermatologie et de Vénéréologie
Author(s): O. Dereure




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Le purpura vélo-palatin « a vacuo » de Barthélemy (1928) revisité

Publication date: Available online 15 September 2016
Source:Annales de Dermatologie et de Vénéréologie
Author(s): N. Kluger




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Scholar : These new articles for International Journal of Heritage Studies are available online

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The online platform for Taylor & Francis Online content New for International Journal of Heritage Studies and online now on Taylor & Francis Online: Original Articles The Hopi, the katsinam, and the French courts: looking outside the law in the repatriation of Indigenous cultural heritage Jonathan Liljeblad Pages: 1-11 | DOI: 10.1080/13527258.2016.1232745 Book Review Water & heritage: material, conceptual and spiritual connections Anna Catalani Pages: 1-2 | DOI: 10.1080/13527258.2016.1232299 European Sport Management Quarterly – Free Access to Editor's Choice Articles. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells

Publication date: 1 January 2017
Source:European Journal of Pharmaceutical Sciences, Volume 96
Author(s): Marcella Manerba, Lorenza Di Ianni, Marzia Govoni, Marinella Roberti, Maurizio Recanatini, Giuseppina Di Stefano
The inflammatory microenvironment is an essential component of neoplastic lesions and can significantly impact on tumor progression. Besides facilitating invasive growth, inflammatory cytokines were also found to reprogram cancer cell metabolism and to induce aerobic glycolysis.Previous studies did not consider the possible contribution played in these changes by lactate dehydrogenase (LDH). The A isoform of LDH (LDH-A) is the master regulator of aerobic glycolysis; it actively reduces pyruvate and causes enhanced lactate levels in tumor tissues. In cancer cells, lactate was recently found to directly increase migration ability; moreover, when released in the microenvironment, it can facilitate matrix remodeling. In this paper, we illustrate that treatment of human colon adenocarcinoma cells with TNF-α and IL-17, two pro-inflammatory cytokines, modifies LDH activity, causing a shift toward the A isoform which results in increased lactate production. At the same time, the two cytokines appeared to induce features of epithelial-mesenchymal transition in the treated cells, such as reduction of E-cadherin levels and increased secretion of metalloproteinases. Noteworthy, oxamate and galloflavin, two inhibitors of LDH activity which reduce lactate production in cells, were found to relieve the inflammation-induced effects.These results suggest LDH-A and/or lactate as common elements at the cross-road between cancer cell metabolism, tumor progression and inflammation. At present, LDH inhibitors suitable for clinical use are actively searched as possible anti-proliferative agents; our data lead to hypothesize for these compounds a wider potential in anticancer treatment.

Graphical abstract

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Evaluate the ability of PVP to inhibit crystallization of amorphous solid dispersions by density functional theory and experimental verify

Publication date: 1 January 2017
Source:European Journal of Pharmaceutical Sciences, Volume 96
Author(s): Bing Wang, Dandan Wang, Shan Zhao, Xiaobin Huang, Jianbin Zhang, Yan Lv, Xiaocen Liu, Guojun Lv, Xiaojun Ma
In this study, we used density functional theory (DFT) to predict polymer-drug interactions, and then evaluated the ability of poly (vinyl pyrrolidone) (PVP) to inhibit crystallization of amorphous solid dispersions by experimental-verification. Solid dispersions of PVP/resveratrol (Res) and PVP/griseofulvin (Gri) were adopted for evaluating the ability of PVP to inhibit crystallization. The density functional theory (DFT) with the B3LYP was used to calculate polymer-drug and drug-drug interactions. Fourier transform infrared spectroscopy (FTIR) was used to confirm hydrogen bonding interactions. Polymer-drug miscibility and drug crystallinity were characterized by the modulated differential scanning calorimetry (MDSC) and X-ray powder diffraction (XRD). The release profiles were studied to investigate the dissolution advantage. DFT results indicated that EPVP-Res>ERes-Res (E: represents hydrogen bonding energy). A strong interaction was formed between PVP and Res. In addition, Fourier transform infrared spectroscopy (FTIR) analysis showed hydrogen bonding formed between PVP and Res, but not between PVP and Gri. MDSC and XRD results suggested that 70–90wt% PVP/Res and PVP/Gri solid dispersions formed amorphous solid dispersions (ASDs). Under the accelerated testing condition, PVP/Res dispersions with higher miscibility quantified as 90/10wt% were more stable than PVP/Gri dispersions. The cumulative dissolution rate of 90wt% PVP/Res dispersions still kept high after 90days storage due to the strong interaction. However, the cumulative dissolution rate of PVP/Gri solid dispersions significantly dropped because of the recrystallization of Gri.

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Scholar : African Journal of Aquatic Science, Volume 41, Issue 3, September 2016 is now available online on Taylor & Francis Online

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The online platform for Taylor & Francis Online content African Journal of Aquatic Science, Volume 41, Issue 3, September 2016 is now available online on Taylor & Francis Online. This new issue contains the following articles: Research Papers Penaeid and carid community changes in the St Lucia estuarine lake system, South Africa, under low water level, extended closed periods and marine reconnection conditions GP Tweddle, DP Cyrus & L Vivier Pages: 251-266 | DOI: 10.2989/16085914.2016.1198886 Mapping inundation extent, frequency and duration in the Okavango Delta from 2001 to 2012 K Thito, P Wolski & M Murray-Hudson Pages: 267-277 | DOI: 10.2989/16085914.2016.1173009 Long-term landscape changes in vegetation structure: fire management in the wetlands of KwaMbonambi, South Africa LB Luvuno, DC Kotze & KP Kirkman Pages: 279-288 | DOI: 10.2989/16085914.2016.1177482 Water cytotoxicity and dioxins bioaccumulation in an Egyptian delta wetland ecosystem MM El-Shazly, El Elzayat, WA Omar, IIA El-Sebeay, YA Edmardash, MM Soliman, KM Abdel Rahman & MS Ibrahim Pages: 289-296 | DOI: 10.2989/16085914.2016.1188263 Health assessment of freshwater fish species from Albasini Dam, outside a DDT-sprayed area in Limpopo province, South Africa: a preliminary study UMC Nibamureke, IEJ Barnhoorn & GM Wagenaar Pages: 297-308 | DOI: 10.2989/16085914.2016.1172198 Mesozooplankton community structure changes in the Mfolozi–Msunduzi estuarine system, South Africa, during contrasting river flow conditions HL Jerling & DP Cyrus Pages: 309-317 | DOI: 10.2989/16085914.2016.1184129 Subfossil diatoms from Hann Park pond, Dakar, Senegal: floristic inventory and palaeoenvironmental reconstruction I Badiane, E Sow, CAK Fofana & C Aw Pages: 319-327 | DOI: 10.2989/16085914.2016.1170664 Lifetable demography and population growth of the rotifer Brachionus angularis in Kenya: influence of temperature and food density EO Ogello, H-J Kim, K Suga & A Hagiwara Pages: 329-336 | DOI: 10.2989/16085914.2016.1186590 Short Notes Efficacy and deficiencies of rapid biomonitoring in biodiversity conservation: a case study in South Africa HM Barber-James & LL Pereira-da-Conceicoa Pages: 337-343 | DOI: 10.2989/16085914.2016.1192019 Name changes and additions to the southern African freshwater fish fauna PH Skelton Pages: 345-351 | DOI: 10.2989/16085914.2016.1186004 Effects of land-use changes on benthic macroinvertebrate assemblages in the tropical Umfurudzi River, Zimbabwe T Bere, G Chiyangwa & T Mwedzi Pages: 353-357 | DOI: 10.2989/16085914.2016.1171201 Book Review Manual of Freshwater Assessment for South Africa: Dragonfly Biotic Index. Suricata 2 Helen M Barber-James Pages: 359-360 | DOI: 10.2989/16085914.2016.1229172 Dive into our Life below Water article collection. Free access to over 50 articles on the world beneath the seas http://ift.tt/2cWo2b1 This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Aphasiology are available online

The online platform for Taylor & Francis Online content New for Aphasiology and online now on Taylor & Francis Online: Original Articles The common denominator in the perception of accents in cases with foreign accent syndrome Roel Jonkers, Fennetta van der Scheer & Dicky Gilbers Pages: 1-23 | DOI: 10.1080/02687038.2016.1232362 Read over 60 free to access articles examining Autism with the World Autism Awareness Day collection. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Culture, Theory and Critique, Volume 57, Issue 3, November 2016 is now available online on Taylor & Francis Online

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The online platform for Taylor & Francis Online content Culture, Theory and Critique, Volume 57, Issue 3, November 2016 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Foucault's Overlooked Organisation: Revisiting his Critical Works Michela Betta Pages: 251-273 | DOI: 10.1080/14735784.2015.1078252 Anxiety and Aporia: Or, What, for Lacan, Makes Deconstruction Reassuring? Clark Buckner Pages: 274-289 | DOI: 10.1080/14735784.2015.1041649 The Senses of Personhood: Beyond Allegories of the Body Alan Singer Pages: 290-312 | DOI: 10.1080/14735784.2014.966225 Fighting for the Other's Rights First: Levinasian Perspectives on Occupy Gezi's Standing Protest Anna-Verena Nosthoff Pages: 313-337 | DOI: 10.1080/14735784.2015.1125300 The Itinerary of Commemoration in the Kigali Memorial Centre: On Trauma, Time and Difference Jennifer Yusin Pages: 338-356 | DOI: 10.1080/14735784.2015.1019158 Reading 'the Whole of World History': An Investigation into Benjamin and Colportage Matthew Von Vogt Pages: 357-372 | DOI: 10.1080/14735784.2015.1090325 Ethics of Incorporation: (Im)possibility of Accepting Otherness in Kawabata's 'One Arm' Fusako Innami Pages: 373-390 | DOI: 10.1080/14735784.2015.1073113 Carmen Goes Postcolonial, Carmen Goes Queer: Thinking the Postcolonial as Queer Ayo A. Coly Pages: 391-407 | DOI: 10.1080/14735784.2015.1056540 Editorial Board Editorial Board Pages: ebi-ebi | DOI: 10.1080/14735784.2016.1236460 Have you discovered Lives in Literature yet? Free access to research on some of Literature's most notable names;new collections will be added regularly so bookmark the page and visit again! This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Criminal Justice Studies are available online

The online platform for Taylor & Francis Online content New for Criminal Justice Studies and online now on Taylor & Francis Online: Original Articles Are self-identified Christian fundamentalists really more supportive of capital punishment? Exploring the relationship between fundamentalism and death penalty attitudes Robert Lytle & Tusty ten Bensel Pages: 1-16 | DOI: 10.1080/1478601X.2016.1231381 Time and tide wait for no man (or woman). Explore the multidisciplinary TIME Collection now. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Contemporary Music Review are available online

The online platform for Taylor & Francis Online content New for Contemporary Music Review and online now on Taylor & Francis Online: Introductions Introduction Stephen Davismoon Pages: 1-1 | DOI: 10.1080/07494467.2016.1220450 Original Articles Atomisation of Sound Stephen Davismoon Pages: 1-12 | DOI: 10.1080/07494467.2016.1221629 Time and tide wait for no man (or woman). Explore the multidisciplinary TIME Collection now. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.