Seguimiento de pacientes pediátricos con histiocitosis de Langerhans mediante PET/TC con 18F-FDG

Publication date: Available online 3 March 2017
Source:Revista Española de Medicina Nuclear e Imagen Molecular
Author(s): J.R. Garcia, E. Riera, P. Bassa, S. Mourelo, M. Soler
ObjetivoEvaluar el impacto de la ¹⁸F-FDG PET/TC en la identificación de focos de enfermedad activa y el seguimiento terapéutico en un grupo de pacientes pediátricos con histiocitosis de células de Langerhans (HCL).MétodoEntre 2007-2013 se efectuaron 13 estudios ¹⁸F-FDG PET/TC de seguimiento en 7 pacientes diagnosticados de HCL (4 niñas, 3 varones; 1-12 años). Se analizaron los hallazgos PET y se correlacionaron con los de la TC y la RM, así como el seguimiento evolutivo con estas técnicas.ResultadosLa PET fue negativa en 4 pacientes (todos diagnosticados de lesiones óseas y afectación hipofisaria en un caso). La TC mostró persistencia de lesiones, de carácter residual, en todos los pacientes, y la RM de hipófisis mostró su normalización. La PET permaneció negativa a los 10, 14, 25 y 28 meses, sin detectar nuevas lesiones mediante TC ni RM. La PET fue positiva en 3 pacientes (uno con adenopatías cervicales y 2 con lesiones óseas y afectación hipofisaria en uno de ellos, no identificada por la PET). Los hallazgos de la TC fueron adenopatía cervical patológica (n=1) y lesiones óseas (n=2), y de la RM, lesión hipofisaria (n=1). En el paciente con adenopatía cervical la anatomía patológica mostró afectación por HCL. En los otros 2 pacientes, la PET permaneció positiva, con aumento de la captación ósea de ¹⁸F-FDG a los 17 y 19 meses.ConclusiónEn este estudio preliminar, la ¹⁸F-FDG PET constituye una técnica de imagen útil, junto con otras pruebas diagnósticas, para identificar lesiones activas y monitorizar la respuesta terapéutica en pacientes pediátricos con HCL.PurposeWe evaluated the impact of ¹⁸F-FDG PET/CT in identifying sites of active disease and to assess therapeutic follow up in a group of pediatric patients with Langerhans cell histiocytosis (LCH).MethodDuring 2007-2013, 13 ¹⁸F-FDG PET/CT studies were performed for follow-up in 7 patients with a diagnosis of LCH (4 female, 3 male; 1-12 years-old). PET findings were analyzed and correlated with the CT and MRI. Findings were also follow-up by these techniques.ResultsPET was negative in 4 patients (all diagnosed with bone lesions and one with pituitary involvement also). CT findings showed residual morphological bone lesions in all patients, and hypophysis MRI study showed no abnormal signal. PET remained negative at 10, 14, 25 and 28 months, and no new lesions on CT and MRI were detected. PET was positive in 3 patients (one with cervical lymphadenopathy and 2 with bone lesions, one also with pituitary involvement not identified by PET). CT findings showed pathological cervical lymphadenopathy (n=1), bone lesions (n=2) and also a pituitary MRI lesion (n=1). In a patient with cervical lymphadenopathy histology demonstrated LCH involvement. In the other 2 patients, PET remained positive with an increase of ¹⁸F-FDG bone uptake at 17 and 19 months.ConclusionIn our preliminar study, ¹⁸F-FDG PET is a useful imaging procedure, along with other diagnostic tools, for identification of active lesions.



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Incidental meningioma detected by using 99mTc-MIBI SPECT/CT

Publication date: Available online 3 March 2017
Source:Revista Española de Medicina Nuclear e Imagen Molecular
Author(s): D. Albano, L. Camoni, G. Bosio, F. Bertagna




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Hydrothorax secondary to peritoneal dialysis detected by peritoneal scintigraphy

Publication date: Available online 3 March 2017
Source:Revista Española de Medicina Nuclear e Imagen Molecular
Author(s): D. Balaguer, P. Abreu, T. Mut, M.D. Reyes, M.C. Plancha, E. Caballero




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Assessment of cardiovascular impairment in obese patients: Limitations and troubleshooting of available imaging tools

Publication date: Available online 3 March 2017
Source:Revista Española de Medicina Nuclear e Imagen Molecular
Author(s): V. Gaudieri, C. Nappi, W. Acampa, R. Assante, E. Zampella, M. Magliulo, M. Petretta, A. Cuocolo
The prevalence and severity of obesity have increased over recent decades, reaching worldwide epidemics. Obesity is associated to coronary artery disease and other risk factors, including hypertension, heart failure and atrial fibrillation, which are all increased in the setting of obesity. Several noninvasive cardiac imaging modalities, such as echocardiography, cardiac computed tomography, magnetic resonance and cardiac gated single-photon emission computed tomography, are available in assessing coronary artery disease and myocardial dysfunction. Yet, in patients with excess adiposity the diagnostic accuracy of these techniques may be limited due to some issues. In this review, we analyze challenges and possibilities to find the optimal cardiac imaging approach to obese population.



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Lésions cutanées de médecine traditionnelle soudanaise

Publication date: Available online 3 March 2017
Source:Annales de Dermatologie et de Vénéréologie
Author(s): P. Charlier, F. Bou Abdallah, Y. Mostefai, L. Brun, C. Hervé




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Editorial Board

Publication date: February 2017
Source:Acta Oecologica, Volume 79





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Synthesis and Molecular Docking Studies of New Furochromone Derivatives As p38 α MAPK Inhibitors Targeting Human Breast Cancer MCF-7cells

Publication date: Available online 3 March 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Kamelia M. Amin, Yasmin M. Syam, Manal M. Anwar, Hamed I. Ali, Tamer M. Abdel-Ghani, Aya M. Serry
Based on the reported high expression of p38α MAP kinase in invasive breast cancers and the activity of different functionalized chromone derivatives as p38α inhibitors, a new set of 4,9-dimethoxy/4-methoxy-7-methyl-5-oxo-5H-furo[3,2-g]chromone derivatives were efficiently synthesized aiming to introduce new p38α MAP kinase suppressors as new anti-breast cancer tools. Using GOLD program, molecular docking study of the target compounds into p38 α MAP kinase binding pocket was performed to highlight their scores, mode of binding and the important interactions to the amino acid residues of the enzyme. MTT assay investigated that fifteen target compounds produced marked cytotoxic potency higher than that obtained by Doxorubicin against MCF-7 cancer cells of IC50 values ranging from 0.007 to 0.17 uM vs IC50; 0.62 uM of doxorubicin. Eleven selected compounds were evaluated for their inhibitory potency against p38 α MAPK kinase. The derivatives IVa, Va,b, VIa, IXb and XIIIa represented significant activity (IC50; 0.19-0.67 uM) comparing to the reference drug SB203580 (IC50; 0.50 uM). In virtue of its promising cytotoxic and p38α MAP kinase inhibition potency, the furochromone derivative IXb was selected as a representative example to investigate its mechanistic effects on cell cycle progression and induction of apoptosis in MCF-7 cell lines. The results showed that the compound IXb induced cell cycle cessation at G2/M phase preventing its mitotic cycle, alongside its noteworthy activation of caspases-9 and -3 which might mediate the apoptosis of MCF-7 cells.

Graphical abstract

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The assessment and appraisal of regenerative medicines and cell therapy products: an exploration of methods for review, economic evaluation and appraisal.

Determining the long-term effectiveness and costs of regenerative medicines will be associated with considerable uncertainty and potential bias, but existing methods are sufficient to incorporate this uncertainty for decision-making.

http://ift.tt/2lD4Y4t

The Fourth Industrial Revolution: Proceedings of a Workshop—in Brief.

In October 2016, the National Academies of Sciences, Engineering, and Medicine held a meeting to consider the Fourth Industrial Revolution and its implications for manufacturing, as well as its likely social and economic effects. The meeting also explored the cross-sector collaboration between government, universities, and industry needed to accommodate emerging developments in the key technologies of the Fourth Industrial Revolution, namely artificial intelligence, virtual and augmented reality, and the Internet of Things. This publication briefly summarizes the presentations and discussions from the meeting.

http://ift.tt/2mARkE1

Unveiling the Role of Senescence-Induced Cellular Plasticity

Publication date: 2 March 2017
Source:Cell Stem Cell, Volume 20, Issue 3
Author(s): Jumpei Taguchi, Yasuhiro Yamada
Mice expressing Yamanaka factors develop teratomas containing iPSCs, suggesting that somatic cells are reprogrammable in vivo. Recent studies in Cell, Science, and this issue of Cell Stem Cell (Ocampo et al., 2016; Mosteiro et al., 2016; Chiche et al., 2017, respectively) report crosstalk between reprogramming and senescence, providing insights on cellular plasticity in multicellular organisms.

Teaser

Mice expressing Yamanaka factors develop teratomas containing iPSCs, suggesting that somatic cells are reprogrammable in vivo. Recent studies in Cell, Science, and this issue of Cell Stem Cell (Ocampo et al., 2016; Mosteiro et al., 2016; Chiche et al., 2016, respectively) report crosstalk between reprogramming and senescence, providing insights on cellular plasticity in multicellular organisms.


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A Back Door to Cortical Development

Publication date: 2 March 2017
Source:Cell Stem Cell, Volume 20, Issue 3
Author(s): Gerd Kempermann
The mammalian cortex develops in an "inside-out" manner, as neural stem and progenitor cells lining the ventricles build the brain from within. Bifari et al. (2017), in this issue of Cell Stem Cell, find a small set of cortical neurons that appear to originate from radial glia-like progenitors in the meninges, suggesting an outside-in contribution to corticogenesis.

Teaser

The mammalian cortex develops in an "inside-out" manner, as neural stem and progenitor cells lining the ventricles build the brain from within. Bifari et al. (2017), in this issue of Cell Stem Cell, find a small set of cortical neurons that appear to originate from radial glia-like progenitors in the meninges, suggesting an outside-in contribution to corticogenesis.


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Pericytes or Mesenchymal Stem Cells: Is That the Question?

Publication date: 2 March 2017
Source:Cell Stem Cell, Volume 20, Issue 3
Author(s): Elena Cano, Véronique Gebala, Holger Gerhardt
For almost a decade, mesenchymal stem cells (MSCs) were believed to reside as perivascular cells in vivo. In this issue of Cell Stem Cell, Guimarães-Camboa et al. (2017) challenge this idea and use lineage tracing to demonstrate that perivascular cells do not behave as tissue-specific progenitors in various organs, despite showing MSC potential in vitro.

Teaser

For almost a decade, mesenchymal stem cells (MSCs) were believed to reside as perivascular cells in vivo. In this issue of Cell Stem Cell, Guimarães-Camboa et al. (2017) challenge this idea and use lineage tracing to demonstrate that perivascular cells do not behave as tissue-specific progenitors in various organs, despite showing MSC potential in vitro.


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Bridging the Gaps: iPSC-Based Models from CHIP to MDS to AML

Publication date: 2 March 2017
Source:Cell Stem Cell, Volume 20, Issue 3
Author(s): Kathrin M. Bernt
Myeloid malignancies exist on a spectrum from asymptomatic clonal hematopoiesis to overt leukemia and exhibit substantial clonal heterogeneity. Both aspects are challenging to capture in experimental models. In two landmark studies in this issue of Cell Stem Cell, Kotini et al. (2017) and Chao et al. (2017) establish iPSC-based experimental platforms that recapitulate disease stages and clonal architecture.

Teaser

Myeloid malignancies exist on a spectrum from asymptomatic clonal hematopoiesis to overt leukemia and exhibit substantial clonal heterogeneity. Both aspects are challenging to capture in experimental models. In two landmark studies in this issue of Cell Stem Cell, Kotini et al. (2017) and Chao et al. (2017) establish iPSC-based experimental platforms that recapitulate disease stages and clonal architecture.


http://ift.tt/2mRJnqd

Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?

Publication date: 2 March 2017
Source:Cell Stem Cell, Volume 20, Issue 3
Author(s): Guillaume Richard-Carpentier, Guy Sauvageau
Prognostic markers that capture leukemia stem cell (LSC) activity can be useful for the risk stratification of acute myeloid leukemia (AML) patients. In a recent issue of Nature, Ng et al. (2016) develop a prognostic score based on a 17-gene expression signature of LSCs to predict outcome in AML patients.

Teaser

Prognostic markers that capture leukemia stem cell (LSC) activity can be useful for the risk stratification of acute myeloid leukemia (AML) patients. In a recent issue of Nature, Ng et al. (2016) develop a prognostic score based on a 17-gene expression signature of LSCs to predict outcome in AML patients.


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Unsaturated Fatty Acids Maintain Cancer Cell Stemness

Publication date: 2 March 2017
Source:Cell Stem Cell, Volume 20, Issue 3
Author(s): Abir Mukherjee, Hilary A. Kenny, Ernst Lengyel
Investigation of the metabolic regulation of cancer stem cells is an emerging field that offers promising approaches for identifying and targeting recalcitrant stem cell populations. In this issue of Cell Stem Cell, Li et al. (2017) indicate that increased lipid desaturation is essential to stem-like characteristics in ovarian cancer cells.

Teaser

Investigation of the metabolic regulation of cancer stem cells is an emerging field that offers promising approaches for identifying and targeting recalcitrant stem cell populations. In this issue of Cell Stem Cell, Li et al. (2017) indicate that increased lipid desaturation is essential to stem-like characteristics in ovarian cancer cells.


http://ift.tt/2mRICNI

DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization

Publication date: 2 March 2017
Source:Cell Stem Cell, Volume 20, Issue 3
Author(s): Alpaslan Tasdogan, Suresh Kumar, Gabriele Allies, Julia Bausinger, Franziska Beckel, Helmut Hofemeister, Medhanie Mulaw, Vikas Madan, Karin Scharffetter-Kochanek, Michaela Feuring-Buske, Konstanze Doehner, Günter Speit, A. Francis Stewart, Hans Joerg Fehling




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IMRT Plus Cisplatin Versus IMRT in Patients With Stage 2 Nasopharyngeal Carcinoma

Condition:   Nasopharyngeal Carcinoma
Interventions:   Radiation: Intensity modulated radiotherapy;   Drug: Cisplatin
Sponsor:   Nanfang Hospital of Southern Medical University
Not yet recruiting - verified September 2016

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Stereotactic Radiotherapy Combined With Chemotherapy or Not for Treatment of Oligometastases in HNSCC

Condition:   Head and Neck Squamous Cell Carcinoma
Interventions:   Drug: Chemotherapy;   Radiation: Stereotactic radiotherapy
Sponsor:   Groupe Oncologie Radiotherapie Tete et Cou
Recruiting - verified February 2017

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Fever and Malaise in an Infant

Publication date: Available online 2 March 2017
Source:The Journal of Emergency Medicine
Author(s): David S. Young, Emily S. Miller, Kriti Bhatia




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Fever and Back Pain in a Preschool Teacher

Publication date: Available online 2 March 2017
Source:The Journal of Emergency Medicine
Author(s): Kimberly A. Stanford, Emily S. Miller, Kriti Bhatia




http://ift.tt/2mAFU31