Cancer Gene Therapy

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A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research. Open for submissions >>

TABLE OF CONTENTS

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Volume 24, Issue 3 (March 2017)

In this issue
Editorial
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Editorial

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The challenges of solid tumor for designer CAR-T therapies: a 25-year perspective

Richard P Junghans

Cancer Gene Ther 2017 24: 89-99; 10.1038/cgt.2016.82

Full Text

Reviews

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Myeloid-derived suppressor cells and their role in pancreatic cancer

M Pergamo and G Miller

Cancer Gene Ther 2017 24: 100-105; advance online publication, December 2, 2016; 10.1038/cgt.2016.65

Abstract | Full Text

T-cell programming in pancreatic adenocarcinoma: a review

Y D Seo and V G Pillarisetty

Cancer Gene Ther 2017 24: 106-113; advance online publication, December 2, 2016; 10.1038/cgt.2016.66

Abstract | Full Text

Immunosuppression in liver tumors: opening the portal to effective immunotherapy

P Guha, J Reha and S C Katz

Cancer Gene Ther 2017 24: 114-120; advance online publication, December 2, 2016; 10.1038/cgt.2016.54

Abstract | Full Text

Chimeric antigen receptors for treatment of glioblastoma: a practical review of challenges and ways to overcome them

S Sengupta, G Mao, Z S Gokaslan and P Sampath

Cancer Gene Ther 2017 24: 121-129; advance online publication, October 21, 2016; 10.1038/cgt.2016.46

Abstract | Full Text

Current status of immunotherapy for gastrointestinal stromal tumor

Y Tan, J C Trent, B A Wilky, D A Kerr and A E Rosenberg

Cancer Gene Ther 2017 24: 130-133; advance online publication, February 10, 2017; 10.1038/cgt.2016.58

Abstract | Full Text

Gene-expression profiling to predict responsiveness to immunotherapy

N B Jamieson and A V Maker

Cancer Gene Ther 2017 24: 134-140; advance online publication, November 11, 2016; 10.1038/cgt.2016.63

Abstract | Full Text

Combinatorial immunotherapy for melanoma

D D George, V A Armenio and S C Katz

Cancer Gene Ther 2017 24: 141-147; advance online publication, November 11, 2016; 10.1038/cgt.2016.56

Abstract | Full Text

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Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Environnement, Risques & Santé

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Environnement, Risques & Santé Volume 16, numéro 2, 2017 Retrouvez le dernier numéro de votre revue Environnement, Risques & Santé A lire notamment dans ce numéro : - Éléments de réflexions sur l'hypersensibilité électromagnétique et les intolérances environnementales idiopathiques - Énergie et intolérances environnementales : électro-hypersensibilité, syndrome éolien, qu'en est-il vraiment ? Toujours pas abonné ? Retrouvez nos offres sur www.revue-ers.fr Bonne lecture à tous !

    SOMMAIRE :

Éditorial/Editorial

Éléments de réflexions sur l'hypersensibilité électromagnétique et les intolérances environnementales idiopathiques Anne Perrin

Brèves/News from the Literature

>  Chaleur et arrêts de grossesse en Californie* Laurence Nicolle-Mir

>  Évolution de la vulnérabilité à la chaleur et au froid : revue de la littérature* Laurence Nicolle-Mir

>  Mortalité liée à la chaleur au cours de l'été : analyse multi-pays* Laurence Nicolle-Mir

>  Pollution atmosphérique et asthme infantile : vaste étude québécoise sur les cas incidents* Laurence Nicolle-Mir

>  Exposition des écoliers aux polluants et au bruit du trafic et problèmes comportementaux* Laurence Nicolle-Mir

>  Substances toxiques dans l'air ambiant et tumeurs cérébrales de l'enfant : étude californienne* Laurence Nicolle-Mir

>  Maladie de Parkinson et expositions environnementales : état des connaissances* Laurence Nicolle-Mir

>  Polluants environnementaux et santé de l'enfant : apports des récentes publications* Laurence Nicolle-Mir

>  Expositions chimiques et anomalies congénitales : analyse de la littérature* Laurence Nicolle-Mir

>  Mortalité dans une communauté italienne alimentée par une eau riche en sélénium inorganique* Laurence Nicolle-Mir

>  Consommation de poisson, mercure plasmatique et issues de grossesse dans une cohorte britannique* Laurence Nicolle-Mir

Sur le Web/On the Web

>  De Laurence Nicolle-Mir

Synthèse/General Review

Énergie et intolérances environnementales : électro-hypersensibilité, syndrome éolien, qu'en est-il vraiment ? Monique Bonnet-Belfais, Jacques Lambrozo, Martine Souques, Aleksandra Piotrowski, Paul Tossa

Articles originaux/Original Articles

>  Comparaison des contaminations et des expositions alimentaires des années 1970, 2000 et 2010 Clarisse Ledoux, Véronique Sirot, Gilles Rivière

>  L'évaluation de la sécurité chimique dans REACH : principes et premiers retours d'expérience Pierre Lecoq, Laura Maxim, Cécile Michel, Jean-Ulrich Mullot

>  Évaluation de l'imprégnation mercurielle chez les nouveau-nés dans la région d'Azzaba (Algérie) Rachid Djafer, Myriam Megueddem, Barkaham Alamir

Point de vue/Point of View

>  Convergence NBIC : risques et conditions de possibilité au regard d'autres risques « silencieux » Jean-Claude André

Portrait/Portrait

>  Plan « Paris Santé Environnement » et Service parisien de santé environnementale Georges Salines

Législation/Legislation

>  De Laurence Nicolle-Mir

Compte rendu de congrès/Congress Review

>  Society for Risk Analysis, 2016 Pierre-André Cabanes

Ouvrages parus/Recent Publications

>  Ouvrages parus

Bloc-Notes/Notepad

>  Bloc-Notes

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Evaluating impacts of recharging partially treated wastewater on groundwater aquifer in semi-arid region by integration of monitoring program and GIS technique

Abstract

The current study investigates the impact of recharging of partially treated wastewater through an infiltration basin on the groundwater aquifer quality parameters. A monitoring program supported by a geographic information analysis (GIS) tool was used to conduct this study. Groundwater samples from the entire surrounding boreholes located downstream the infiltration basin, in addition to samples from the recharged wastewater coming from the Beit Lahia wastewater treatment (BLWWTP), were monitored and analysed between 2011 and 2014. The analysis was then compared with the available historical data since 2008. Results revealed a groundwater replenishment with the groundwater level increased by 1.0–2.0 m during the study period. It also showed a slight improvement in the groundwater quality parameters, mainly a decrease in TDS, Cl⁻ and NO₃⁻ levels by 5.5, 17.1 and 20%, respectively, resulting from the relatively better quality of the recharged wastewater. Nevertheless, the level of boron and ammonium in the groundwater wells showed a significant increase over time by 96 and 100%, respectively. Moreover, the infiltration rate was slowed down in time due to the relatively high level of total suspended solid (TSS) in the infiltrated wastewater.

http://ift.tt/2ojvO4z

Synergetic effect of rhamnolipid from Pseudomonas aeruginosa C1501 and phytotoxic metabolite from Lasiodiplodia pseudotheobromae C1136 on Amaranthus hybridus L. and Echinochloa crus-galli weeds

Abstract

Rhamnolipid (Rh) is a biosurfactant produced by the bacterial Pseudomonas aeruginosa. This present study investigates rhizospheric strain C1501 of P. aeruginosa with an accession number KF976394 with the best production of rhamnolipid: a biosurfactant. The partially purified rhamnolipid from strain C1501 and Tween 80 was tested on mycelial growth of wild strain C1136. The enzyme activities involved in biodegradation, as well as necrosis induction on the tested weeds, were performed using scanning electron microscopy. It was observed that the different concentrations of rhamnolipid tested enhanced the dry mycelia weight yield of Lasiodiplodia pseudotheobromae which has been established to be producing a phytotoxic metabolite for killing weeds. It was observed that strain C1136 had a high level of cellulase and xylanase enzyme activities during this study. The scanning electron microscopy showed that the mutant strain of C1136 combined with 0.003% v/v of rhamnolipid enhances biodegradability and a high level of necrosis on the tested weeds compared with that on the untreated weeds. The highest CMCase activities and xylanase activities were obtained on the fourth day from the phytotoxic metabolite produced from the mutant strain of L. pseudotheobromae when combined with 0.003% v/v of rhamnolipid. This study has shown that rhamnolipid can serve as an adjuvant in order to enhance the penetrability of bioherbicide active ingredient for controlling weeds.

http://ift.tt/2oXFNiS

PCDD/F formation during thermal desorption of p,p′-DDT contaminated soil

Abstract

Thermal treatment of polychlorinated biphenyls (PCB) contaminated soil was shown in earlier work to generate polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF). In this study, the PCDD/F were studied arising during the remediation of p,p′-DDT contaminated soil by thermal desorption. Three kinds of soil (sandy, clayey and lateritic soil) were tested to investigate the effect of soil texture on PCDD/F formation. Those soils were artificially polluted with p,p′-DDT, obtaining a concentration level of 100 mg/kg. Thermal desorption experiments were conducted for 10 min at 300 °C in an air atmosphere. The total concentration of PCDD/F generated for three soils were 331, 803 and 865 ng/kg, respectively, and TeCDD and TeCDF were dominant among all PCDD/F congeners. After thermal desorption, the total amount of PCDD/F generated both in soil and in off-gas correlated positively with the amount of DDT added to soil. In addition, a possible pathway of the formation of PCDD/F was presented.

http://ift.tt/2ojx7k2

Proteomic analysis of continuous 900-MHz radiofrequency electromagnetic field exposure in testicular tissue: a rat model of human cell phone exposure

Abstract

Although cell phones have been used worldwide, some adverse and toxic effects were reported for this communication technology apparatus. To analyze in vivo effects of exposure to radiofrequency-electromagnetic field (RF-EMF) on protein expression in rat testicular proteome, 20 Sprague-Dawley rats were exposed to 900 MHz RF-EMF for 0, 1, 2, or 4 h/day for 30 consecutive days. Protein content of rat testes was separated by high-resolution two-dimensional electrophoresis using immobilized pH gradient (pI 4–7, 7 cm) and 12% acrylamide and identified by MALDI-TOF/TOF-MS. Two protein spots were found differentially overexpressed (P < 0.05) in intensity and volume with induction factors 1.7 times greater after RF-EMF exposure. After 4 h of daily exposure for 30 consecutive days, ATP synthase beta subunit (ASBS) and hypoxia up-regulated protein 1 precursor (HYOU1) were found to be significantly up-regulated. These proteins affect signaling pathways in rat testes and spermatogenesis and play a critical role in protein folding and secretion in the endoplasmic reticulum. Our results indicate that exposure to RF-EMF produces increases in testicular proteins in adults that are related to carcinogenic risk and reproductive damage. In light of the widespread practice of men carrying phones in their pockets near their gonads, where exposures can exceed as-tested guidelines, further study of these effects should be a high priority.

http://ift.tt/2oXE65f

Effect of biochar on alleviation of cadmium toxicity in wheat ( Triticum aestivum L.) grown on Cd-contaminated saline soil

Abstract

Soil degradation by salinity and accumulation of trace elements such as cadmium (Cd) in the soils are expected to become one of the most critical issues hindering sustainable production and feeding the increasing population. Biochar (BC) has been known to protect the plants against soil salinity and heavy metal stress. A soil culture study was performed to evaluate the effect of BC on wheat (Triticum aestivum L.) growth, biomass, and reducing Cd and sodium (Na) uptake grown in Cd-contaminated saline soil under ambient conditions. Soil salinity decreased the plant growth, biomass, grain yield, chlorophyll contents, and gas exchange parameters and caused oxidative stress in plants compared with Cd stress alone. Salt stress increased Cd and Na uptake and reduced the potassium (K) and zinc (Zn) uptake by plants. AB-DTPA-extractable Cd and soil electrical conductivity (ECe) increased under salt stress compared to the soil without NaCl stress. Biochar application improved the plant growth and reduced the Cd and Na uptake except in plants treated with higher BC and salt stress (5.0% BC + 50 mM NaCl). Biochar application reduced the oxidative stress in plants and modified the antioxidant enzyme activities, and reduced the bioavailable Cd under salt stress. The positive effects of BC under lower salt stress while the negative effects of BC under higher BC and salt levels indicated that BC doses should be used with great care in higher soil salinity levels simultaneously contaminated with Cd to avoid the negative effects of BC on growth and metal uptake.

http://ift.tt/2ojBwDK

Seasonal assessment of biological indices, bioaccumulation, and bioavailability of heavy metals in sea urchins Paracentrotus lividus from Algerian west coast, applied to environmental monitoring

Abstract

The aim of the present work was to extend our knowledge on the variability of trace metals in sea urchin tissues, focusing on seasonal fluctuations (2010 February for "winter," May for "spring," August for "summer," November for "autumn") in the three different sampling sites of Algerian west coast (Oran Harbor (S1), Ain Defla (S2), and Hadjaj (belonging to Mostaganem City S3)). For this purpose, the bioavailability (metal indices) and bioaccumulation (metal concentrations in soft tissues) of heavy metals (Zn, Cu, Pb, and Cd), the physiological characteristics (e.g., biological indices such as condition index (CI), repletion index (RI), gonad index (GI)), and the biometric parameters (diameter (D) and the height (H)) of sea urchins Paracentrotus lividus were assessed and related to seasons and sites. To investigate the metal bioavailability to sea urchins more precisely, the metal indices were used as a reliable tool in the present work, instead of the metal concentrations only. The interest to standardize metal concentrations with the weight of the urchin test is to overcome the metal burden variations in the soft tissues of urchin related to the seasonal weight changes of the soft body of animal. We evidence that the most contaminated sites were S1 and S2. Furthermore, it should be noted that the bioavailability of metals, corresponding to the values of metal indices, is also more pronounced in S1 and S2 compared to that measured in S3. Thus, a correlation is observed between seasonal metal content in urchin tissues from the three sites and the corresponding metal indices. The high metal concentrations were obtained during the period when RI and CI were highest. So, it appears that the bioaccumulation of metals in sea urchins of the three sites studied is significantly influenced by the reproductive cycle and diet, feeding activity, and physiological state of these organisms. We noticed that the sea urchins from the sites S1 and S2 were small in size. It is probable that these animals, whose internal tissues contained high concentrations of metals, have been exposed to metal pollution, which might have affected both their growth and altered their physiological capacity. This approach is very original and might be used in the monitoring of the quality of coastal waters, and the present work provided a useful data set for Mediterranean monitoring network.

http://ift.tt/2oXxC69

Optimal air quality policies and health: a multi-objective nonlinear approach

Abstract

The use of modelling tools to support decision-makers to plan air quality policies is now quite widespread in Europe. In this paper, the Regional Integrated Assessment Tool (RIAT+), which was designed to support policy-maker decision on optimal emission reduction measures to improve air quality at minimum costs, is applied to the Porto Urban Area (Portugal). In addition to technological measures, some local measures were included in the optimization process. Case study results are presented for a multi-objective approach focused on both NO₂ and PM10 control measures, assuming equivalent importance in the optimization process. The optimal set of air quality measures is capable to reduce simultaneously the annual average concentrations values of PM10 and NO₂ in 1.7 and 1.0 μg/m³, respectively. This paper illustrates how the tool could be used to prioritize policy objectives and help making informed decisions about reducing air pollution and improving public health.

http://ift.tt/2ojqwpL