Publication date: Available online 9 March 2018
Source:Critical Reviews in Oncology/Hematology
Author(s): Domenico Ciliberto, Nicoletta Staropoli, Francesca Caglioti, Silvia Chiellino, Antonella Ierardi, Rossana Ingargiola, Cirino Botta, Mariamena Arbitrio, Pierpaolo Correale, Pierfrancesco Tassone, Pierosandro Tagliaferri
BackgroundAt present, there is uncertainty on the best systemic treatment in first-line setting for RAS wild-type (WT) metastatic colorectal cancer (mCRC) patients. Indeed, several chemotherapy and biologics combinations showed an improvement on survival. We performed a systematic review with a pair-wise and bayesan meta-analysis to rank the best strategy for these patients.MethodsA systematic literature search through March 2017 was performed to evaluate the association between several treatment combinations and overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicity rate (TR) in RAS WT mCRC patients. Data were extracted from studies and pooled using the random-effect model for pair-wise meta-analyses and bayesan model for network meta-analysis (NMA).ResultsEight studies with a total of 2518 individuals were included in the meta-analyses. Pooled analyses for subgroups stratified by type of schedule and tumor location demonstrated that anti-EGFR + doublet had the best OS when compared to doublet ± bevacizumab (0.767; 95%CI, 0.695–0.846; P < .0001). This benefit is limited to LSCC when compared to a doublet-based schedule and doublet + bevacizumab (HRs, 0.692; 95%CI, 0.596–0.804; P < .001; 0.706; 95%CI, 0.584–0.854; P < .001; respectively). No significant differences are detected in PFS, whereas the cetuximab-based regimens showed the highest ORR and TR. In NMA our ranking showed the best performance for FOLFOX + panitumumab.ConclusionsOur study indicates that FOLFOX + panitumumab has the major probability to provide an improvement of survival with a good safety profile in patients with RAS WT mCRC with an added value from selection based on sidedness.
http://ift.tt/2IdPf8u
Σάββατο 10 Μαρτίου 2018
The best strategy for RAS wild-type metastatic colorectal cancer patients in first-line treatment: a classic and Bayesian meta-analysis
Review and clinical experience exploring evidence, clinical efficacy, and safety regarding nonsurgical treatment of feminine rejuvenation
Summary
Introduction
The use of energy-based devices for the treatment of vaginal laxity, orgasmic dysfunction, and stress incontinence, such as minimally ablative fractional laser and radiofrequency, is gaining momentum. This review aims to answer clinical questions on the application of energy-based devices for feminine genital rejuvenation.
Methods
The target group includes physicians involved in esthetic medicine and feminine genital rejuvenation. A literature review was conducted on technologies in use for feminine rejuvenation to explore their safety, efficacy, tolerability, patient satisfaction, and clinical usability. A panel of physicians with clinical experience conducting these types of treatment reviewed and discussed the results of the literature search and gave clinical evidence-based recommendations.
Results
Energy-based devices may induce wound healing, stimulating new collagen, and elastin fiber formation. Radiofrequency treatment may also increase small nerve fiber density in the papillary dermis, improving nerve sensitivity, sexual function, including arousal and orgasmic dysfunction. Both minimally ablative fractional laser and radiofrequency has been shown to be effective when treating mild to moderate primary or secondary vulvovaginal laxity and associated secondary conditions. These treatments are reported to be safe, effective, and well tolerated with a rapid return to activities of daily living.
Conclusions
As this is an evolving medical field, clinical evidence often lacks robustness. Studies and clinical experience suggest that feminine genital rejuvenation using energy-based devices seems an attractive option for patients with mild-to-moderate medical conditions. The treatment can be safely and effectively delivered by trained staff as part of the comprehensive care, that is, currently available to women.
http://ift.tt/2p1VZ0u
Effect of narrow-band ultraviolet B on the serum of 25-hydroxyvitamin D in vitiligo patients
Summary
Background
Narrow-band ultraviolet B (NB-UVB) is the gold standard in the treatment of vitiligo. 25-hydroxyvitamin D (25-OH- vitamin D) might play a physiological role in photo-induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly.
Objective
we aim to investigate the influence of cumulative doses of NB-UVB phototherapy on vitamin D in patients with vitiligo and their correlation with NB-UVB-induced pigmentation.
Methods
Eighty patients of vitiligo and twenty number of age and sex matched controls were recruited in a case-control study. Patients with vitiligo were treated with NB-UVB twice weekly for 24 weeks. 25-hydroxy vitamin D levels were measured at 0, 12, and 24 weeks in the cases and at 0 only in control by enzyme-linked immunosorbent assay (ELISA) and Vitiligo Area Severity Index (VASI) were calculated at 0 (baseline) and 24 weeks.
Results
The mean baseline level of 25-hydroxyvitamin D (at 0 week) was significantly lower in patients than the control group. Levels of 25(OH) vitamin D at 12 and 24 weeks showed significant improvement and Patients show significant reduction in VASI score after 24 weeks of therapy.
Conclusions
Cumulative doses of NB-UVB therapy improve low vitamin D levels in patients with vitiligo, which might have a significant role in NB-UVB-induced repigmentation and may contribute to its therapeutic efficacy but further studies with larger sample size are needed to prove the complete mechanisms of NB-UVB-induced pigmentations and vitamin D in vitiligo.
http://ift.tt/2Ij9XUK
A wearable electrochemical glucose sensor based on simple and low-cost fabrication supported micro-patterned reduced graphene oxide nanocomposite electrode on flexible substrate
Source:Biosensors and Bioelectronics, Volume 109
Author(s): Xing Xuan, Hyo S. Yoon, Jae Y. Park
In this study, a reduced graphene oxide (rGO)-based nanostructured composite working electrode of high quality was successfully microfabricated and micro-patterned on a flexible polyimide substrate using simple low-cost fabrication processes. Gold and platinum alloy nanoparticles were electrochemically deposited onto the microfabricated rGO surface and chitosan-glucose oxidase composites were integrated onto the modified surface of the working electrode to develop a human sweat-based wearable glucose sensor application. The fabricated biosensor exhibited excellent amperometric response to glucose at a detection range of 0–2.4 mM (covers the glucose range in sweat), with a sensitivity of 48 μA/mMcm2, a short response time (20 s), and high linearity (0.99). The detection limit for glucose was calculated as 5 µm. The human sweat/mixing glucose samples initially used for testing indicated acceptable detection performance and stability for low glucose concentrations. These results confirm that the proposed nanostructured composite flexible working electrode and fabrication process are highly promising for application as human sweat-based electrochemical glucose sensors.
http://ift.tt/2DfLZWC
Novel photoluminescence enzyme immunoassay based on supramolecular host-guest recognition using L-arginine/6-aza-2-thiothymine-stabilized gold nanocluster
Source:Biosensors and Bioelectronics, Volume 109
Author(s): Youmei Wang, Minghua Lu, Dianping Tang
A new photoluminescence (PL) enzyme immunoassay was designed for sensitive detection of aflatoxin B1 (AFB1) via an innovative enzyme substrate, 6-aza-2-thiothymine-stabilized gold nanocluster (AAT-AuNC) with L-arginine. The enzyme substrate with strong PL intensity was formed through supramolecular host-guest assembly between guanidine group of L-arginine and AAT capped on the surface of AuNC. Upon arginase introduction, the captured L-arginine was hydrolyzed into ornithine and urea, thus resulting in the decreasing PL intensity. Based on this principle, a novel competitive-type immunoreaction was first carried out on AFB1-bovine serum albumin (AFB1-BSA) conjugate-coated microplate, using arginase-labeled anti-AFB1 antibody as the competitor. Under the optimum conditions, the PL intensity increased with the increment of target AFB1, and allowed the detection of the analyte at concentrations as low as 3.2 pg mL−1 (ppt). Moreover, L-arginine-AAT-AuNC-based PL enzyme immunoassay afforded good reproducibility and acceptable specificity. In addition, the accuracy of this methodology, referring to commercial AFB1 ELISA kit, was evaluated to analyze naturally contaminated or spiked peanut samples, giving well-matched results between two methods, thus representing a useful scheme for practical application in quantitative monitoring of mycotoxins in foodstuff.
http://ift.tt/2oYvTMH
Παρασκευή 9 Μαρτίου 2018
Rapid fully automatic segmentation of subcortical brain structures by shape-constrained surface adaptation
Publication date: Available online 9 March 2018
Source:Medical Image Analysis
Author(s): Fabian Wenzel, Carsten Meyer, Thomas Stehle, Jochen Peters, Susanne Siemonsen, Christian Thaler, Lyubomir Zagorchev
This work presents a novel approach for the rapid segmentation of clinically relevant subcortical brain structures in T1-weighted MRI by utilizing a shape-constrained deformable surface model. In contrast to other approaches for segmenting brain structures, its design allows for parallel segmentation of individual brain structures within a flexible and robust hierarchical framework such that accurate adaptation and volume computation can be achieved within a minute of processing time. Furthermore, adaptation is driven by local and not global contrast, potentially relaxing requirements with respect to preprocessing steps such as bias-field correction. Detailed evaluation experiments on more than 1000 subjects, including comparisons to FSL FIRST and FreeSurfer as well as a clinical assessment, demonstrate high accuracy and test-retest consistency of the presented segmentation approach, leading, for example, to an average segmentation error of less than 0.5 mm. The presented approach might be useful in both, research as well as clinical routine, for automated segmentation and volume quantification of subcortical brain structures in order to increase confidence in the diagnosis of neuro-degenerative disorders, such as Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, or clinical applications for other neurologic and psychiatric diseases.
Graphical abstract
http://ift.tt/2HmptOp
Estimating fiber orientation distribution from diffusion MRI with spherical needlets
Publication date: Available online 8 February 2018
Source:Medical Image Analysis
Author(s): Hao Yan, Owen Carmichael, Debashis Paul, Jie Peng
We present a novel method for estimation of the fiber orientation distribution (FOD) function based on diffusion-weighted magnetic resonance imaging (D-MRI) data. We formulate the problem of FOD estimation as a regression problem through spherical deconvolution and a sparse representation of the FOD by a spherical needlets basis that forms a multi-resolution tight frame for spherical functions. This sparse representation allows us to estimate the FOD by ℓ1-penalized regression under a non-negativity constraint on the estimated FOD. The resulting convex optimization problem is solved by an alternating direction method of multipliers (ADMM) algorithm. The proposed method leads to a reconstruction of the FOD that is accurate, has low variability and preserves sharp features. Through extensive experiments, we demonstrate the effectiveness and favorable performance of the proposed method compared to three existing methods. Specifically, we demonstrate that the proposed method is able to successfully resolve fiber crossings at small angles and automatically identify isotropic diffusion. We also apply the proposed method to real 3T D-MRI data sets of healthy individuals. The results show realistic depictions of crossing fibers that are more accurate, less noisy, and lead to superior tractography results compared to competing methods.
Graphical abstract
http://ift.tt/2FrQgMN
Focal immune-related pancreatitis occurring after treatment with programmed cell death 1 inhibitors: a distinct form of autoimmune pancreatitis?
Source:European Journal of Cancer
Author(s): Gabriele Capurso, Livia Archibugi, Laura Tessieri, Maria Chiara Petrone, Andrea Laghi, Paolo Giorgio Arcidiacono
http://ift.tt/2IeudGS
Immune checkpoint therapy in proteinuric kidney disease
Source:European Journal of Cancer
Author(s): Tsuneo Takenaka, Yohko Kawai, Takahiro Amano
http://ift.tt/2DfIDTp
Whole genome sequence and phenotypic characterization of a Cbm+ serotype e strain of Streptococcus mutans
Abstract
We report the whole genome sequence (WGS) of the serotype e Cbm+ strain LAR01 of Streptococcus mutans, a dental pathogen frequently associated with extra-oral infections. The LAR01 genome is a single circular chromosome of 2.1 Mb with a GC content of 36.96%. The genome contains 15 PTS gene clusters, 7 cell wall-anchored (LPxTG) proteins, all genes required for the development of natural competence and genes coding for mutacins VI and K8. Interestingly, the cbm gene is genetically linked to a putative type VII secretion system that has been found in Mycobacteria and few other gram-positive bacteria. When compared to the UA159 type strain, phenotypic characterization of LAR01 revealed increased biofilm formation in the presence of either glucose or sucrose but similar abilities to withstand acid and oxidative stresses. LAR01 was unable to inhibit the growth of S. gordonii, which is consistent with the genomic data that indicates absence of mutacins that can kill mitis streptococci. On the other hand, LAR01 effectively inhibited growth of other S. mutans strains suggesting that it may be specialized to outcompete strains from its own species. In vitro and in vivo studies using mutational and heterologous expression approaches revealed that Cbm is a virulence factor of S. mutans by mediating binding to extracellular matrix proteins and intracellular invasion. Collectively, the WGS analysis and phenotypic characterization of LAR01 provides new insights on the virulence properties of S. mutans and grants further opportunities to understand the genomic fluidity of this important human pathogen.
This article is protected by copyright. All rights reserved
http://ift.tt/2tANJKi
Blunt cannula subcision is more effective than Nokor needle subcision for acne scars treatment
Summary
Background and aim
A comprehensive study comparing two different modalities, Nokor needle subcision (NNS) and blunt cannula subcision (BCS), for treatment of acne scars, has not been reported previously. The aim was to compare the effectiveness of these two methods based on patient's and doctor's satisfaction measures, in addition to the late complications 3 months postsubcision.
Method of intervention
Patients had 18-65 years old, with acne scars on both malar sides. They were treated at one malar side with NNS and with BCS at another side. They were monitored during the first week, at one and 3 months postintervention. Patient's and two dermatologist's satisfactions were compared during 3 months, for each modality and between modalities.
Results
From 34 patients, 29.4%, 55.9%, and 14.7% had mild, moderate, and severe acne scars, respectively. Ecchymosis, nodule formation post-NNS, and edema after BCS were the complications. Patients were satisfied with BCS during 3-month monitoring (P = .021), but not with NNS (P = .353). Physician-1 was satisfied from the outcome of both BCS and NNS procedures (P = .044 and .006, respectively). However, physician-2 was only satisfied with NNS at the month 3 than the month 1 (P = .002). All patients and physicians were significantly more satisfied with BCS than NNS (P = .000). Anyway, at the month 3, physician-2 had no significant different points of view about applied methods (P = .25).
Discussion
Considering the complications and satisfaction rates, BCS was more efficient than NNS for acne scar treatment. Then, we suggest BCS as a good replacement for NNS.
http://ift.tt/2G9y2MR
Antiaging and antioxidant effects of topical autophagy activator: A randomized, placebo-controlled, double-blinded study
Summary
Background
Recently, potential roles of autophagy in skin homeostasis received many interests. But, little has been reported for the potential antiaging effects of autophagy activator.
Objective
With the newly synthesized autophagy activator, heptasodium hexacarboxymethyl dipeptide-12 (Aquatide™) in vitro and clinical efficacy of the topical autophagy activator as an antiaging cosmeceutical ingredient was evaluated.
Methods
Antioxidant effect of Aquatide™ was evaluated by radical scavenging assay. In vitro effect was assessed by measuring the cytotoxicity of hydrogen peroxide in cultured normal human epidermal keratinocytes. Clinical evaluation was performed by a randomized, placebo-controlled, double-blinded study. Antioxidant efficacy was observed by measuring the carbonylated proteins in stratum corneum (SC) by fluorescein-5-thiosemicarbazide (FTZ) staining.
Results
Radical scavenging effects of Aquatide were observed with the ABTS assay, and significant reduction in hydrogen peroxide-induced cytotoxicity was observed in Aquatide™-treated cells. Autophagy inhibitor treatment abrogated cytoprotective effects of Aquatide™. In a clinical study, statistically significant increase in skin elasticity was observed after 4 and 8 weeks. Quantitative analysis of carbonylated proteins in SC also showed significant reduction in Aquatide™-treated group, which is consistent with the in vitro data.
Conclusion
These results suggest that autophagy plays important roles in antioxidant system and aging process in skin, and topical autophagy activators can be potential cosmeceutical ingredients for skin antiaging.
http://ift.tt/2FFCB3C
Meta-Analysis: Contrast-Enhanced Ultrasound Versus Conventional Ultrasound for Differentiation of Benign and Malignant Breast Lesions
Source:Ultrasound in Medicine & Biology
Author(s): Qian Li, Min Hu, Zhikui Chen, Changtian Li, Xi Zhang, Yiqing Song, Feixiang Xiang
This meta-analysis aimed to compare the diagnostic performance of contrast-enhanced ultrasound (CEUS), conventional ultrasound (US) combined with CEUS (US + CEUS) and US for distinguishing breast lesions. From thorough literature research, studies that compared the diagnostic performance of CEUS versus US or US + CEUS versus US, using pathology results as the gold standard, were included. A total of 10 studies were included, of which 9 compared the diagnostic performance of CEUS and US, and 5 studies compared US + CEUS and US. In those comparing CEUS versus US, the pooled sensitivity was 0.93 (95% CI: 0.91–0.95) versus 0.87 (95% CI: 0.85–0.90) and pooled specificity was 0.86 (95% CI: 0.84–0.88) versus 0.72 (95% CI: 0.69–0.75). In studies comparing US + CEUS versus US, the pooled sensitivity was 0.94 (95% CI: 0.92–0.96) versus 0.87 (95% CI: 0.84–0.90) and pooled specificity was 0.86 (95% CI: 0.82–0.89) versus 0.80 (95% CI: 0.76–0.84). In terms of diagnosing breast malignancy, areas under the curve of the summary receiver operating characteristic (of both CEUS (p = 0.003) and US + CEUS (p = 0.000) were statistically higher than that of US. Both CEUS alone and US + CEUS had better diagnostic performance than US in differentiation of breast lesions, and US + CEUS also had low negative likelihood ratio.
http://ift.tt/2DfmEfs
In situ DSC investigation into the kinetics and microstructure of dispersoid formation in Al-Mn-Fe-Si(-Mg) alloys
Publication date: 15 May 2018
Source:Materials & Design, Volume 146
Author(s): Richard H. Kemsies, Benjamin Milkereit, Sigurd Wenner, Randi Holmestad, Olaf Kessler
Dispersoid strengthening in Al-Mn-Fe-Si(-Mg) aluminum wrought alloys can play an important role in applications at elevated temperatures. Fine and evenly distributed dispersoids are needed to increase alloy strength, which can be achieved by conducting an adapted homogenization heat treatment. In this work for the first time, the precipitation behavior of dispersoids in direct chill casted Al-Mn-Fe-Si(-Mg) alloys was systematically investigated in situ during heating by means of differential scanning calorimetry. In situ analysis of the phase transformation kinetics during heating and homogenization was complemented by ex situ testing of the electrical conductivity and Vickers hardness, as well as micro- and nano-structural analyses by optical light and transmission electron microscopy. The influence of the heating rate on precipitation behavior was determined by calorimetric in situ experiments, covering a wide heating rate, ranging from 0.003 to 2K/s. The influence of 400 and 550°C homogenization temperatures and soaking durations on hardness and electrical conductivity was also investigated. The highest dispersoid strengthening was obtained after heat treating the as-cast Mg-containing alloy at 400°C for 3 to 10h. Furthermore, the Mg content heavily influenced the precipitation behavior by forming β-Mg2Si precursor phases, which can act as nucleation sites for dispersoid precipitation.
Graphical abstract
http://ift.tt/2FoOv2I
Slip transfer across γ-TiAl lamellae in tension
Publication date: 15 May 2018
Source:Materials & Design, Volume 146
Author(s): Alberto Jesús Palomares-García, María Teresa Pérez-Prado, Jon Mikel Molina-Aldareguia
This work identifies the mechanisms governing dislocation transmission across lamellar interfaces in a Ti-45Al-2Nb-2Mn (at.%) + 0.8(vol%) TiB2 (Ti4522XD) alloy. With this aim, a microgrip and a microtensile specimen were designed and fabricated using a focused ion beam (FIB), to test micrometer-sized specimens in tension. The deformation mechanisms acting in a microtensile specimen of a Ti4522XD alloy were investigated through electron backscatter diffraction (EBSD) and transmission electron microscopy (TEM). The results revealed that domain boundaries (order variant) and lamellar interfaces (order variant, true twin and pseudo-twin) are relatively transparent to dislocation propagation, but they present significant differences in the geometrical alignment between the incoming and outgoing slip systems. While for order variant interfaces, the incoming and outgoing slip systems are perfectly aligned, true twin and pseudo twin interfaces require a change in slip plane and direction, which leaves residual dislocations with Burgers vectors lying on the interface plane. The analysis of the slip transfer mechanisms revealed that the outgoing slip system is governed more by the maximum geometrical alignment, than the applied resolved shear stress.
Graphical abstract
http://ift.tt/2FxOfu7
Fatigue driven matrix crack propagation in laminated composites
Publication date: 15 May 2018
Source:Materials & Design, Volume 146
Author(s): Bijan Mohammadi, Hamed Pakdel
An energy based evolution rule is developed to predict the propagation of mid and outer-ply matrix cracks in laminates with the layups of [0n/θm] s and [θm/0n] s subject to tensile fatigue loading from initiation up to saturation. A unit cell based variational approach is developed to model the damage state considering both crack density and distribution pattern. Crack densities for different layups are then predicted using only two unit effective material properties which are independent from geometry of laminate. Numerous specimens with 8 different layups are tested and during tensile fatigue loading, matrix cracks multiplication is monitored on site using an appropriate optical microscopy setup. Both material properties of Paris like evolution equation are derived based on experimental observations of crack density in two general layups. Analytically predicted crack densities of tested specimens are shown to be in agreement with experimental observations which confirms empirical parameters to be independent from layup in the tested carbon-epoxy specimens. The independence of the empirical parameters from layup and loading must be validated using extensive experimental results of different layups and materials considering different modes of damage.
Graphical abstract
http://ift.tt/2Gb3cU6
Scholar : ΑΚΟΗ - νέα αποτελέσματα
[PDF] Η συμβολή των γραφιστικών τεχνών στις δημόσιες σχέσεις και την επικοινωνία
Αριστοτέλης και Πλάτωνας τη θεωρούσαν πηγή γνώσης. Αισθήσεις Απόδοση % 1. Όραση
87 2. Ακοή 7 3. Όσφρηση 3,5 4. Αφή 1,5 5. Γεύση 1 Σύνολο 100 …
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[PDF] Σεξουαλική αγωγή και σχολική υγιεινή στους εφήβους
ΤΠΔΤΘΤΝΗ ΔΚΠΑΙΓΔΤΣΙΚΟ: Δπξπδίθε Παπαγηαλλνπνύινπ ΙΧΑΝΝΙΝΑ, 2018 ΠΣΤΥΙΑΚΗ
ΔΡΓΑΙΑ Σεξουαλική Αγωγή & Σχολική Υγιεινή στους Εφήβους Page 2. 2 Πεξηερόκελα …
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Scholar : ογκοι κεφαλης τραχηλου - νέα
[PDF] Καρκίνος ωοθηκών και νοσηλευτικές παρεμβάσεις
όγκους που εμφάνιζαν εσωτερικά η εξωτερικά έλκη και διογκώσεις (Netter, 2007) … 20 ετών.
Στις νεαρές ηλικίες οι όγκοι προέρχονται από τα γεννητικά κύτταρα κατά τα 2/3 (Σκαλκίδου …
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[PDF] Ανάπτυξη αυτομάτων συστημάτων Η/Υ για εκπομπή ηλεκτρομαγνητικών κυμάτων επανασυντονισμού κακοήθων εξεργασιών
σαρκωματικών όγκων πειραματόζωων Αντώνιος Χρ. Αυδίκος ΜΑθΗΜΑΤΙΚΟΣ … 77
4.2.2 Αναστολή της ανάπτυξης των όγκων σε επίμυες Wistar..... 77 …
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[PDF] Γνώσεις και αντιλήψεις πρωτοετών φοιτητών νοσηλευτικής για τη σεξουαλική τους συμπεριφορά.
ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ ΚΑΙ ΠΡΟΝΟΙΑΣ ΤΜΗΜΑ ΝΟΣΗΛΕΥΤΙΚΗΣ ΠΤΥΧΙΑΚΗ
ΕΡΓΑΣΙΑ "ΓΝΩΣΕΙΣ ΚΑΙ ΑΝΤΙΛΗΨΕΙΣ ΠΡΩΤΟΕΤΩΝ ΦΟΙΤΗΤΩΝ …
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Scholar : Undersea "Hyperbaric Medicine" - νέα αποτελέσματα
Současný pohled na otravu oxidem uhelnatým y České republice.
společností číslo kPa a vyšší dle European Committee for Hyperbaric Medicine ECHM
či kPa a vyšší dle Undersea and Hyperbaric Medicine Society UHMS …
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Publication date: September 2017 Source: Free Radical Biology and Medicine, Volume 110 Author(s): Lucía Fernández-del-Río, Anish Nag, Elen...
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Abstract Noise pollution is a major factor of environmental complaints in many cities, which has significant impacts on human health. As a...
