A retentive memory of tetrachloroethene respiration in Sulfurospirillum halorespirans - involved proteins and a possible link to acetylation of a two-component regulatory system

Publication date: Available online 1 April 2018
Source:Journal of Proteomics
Author(s): Dominique Türkowsky, Jens Esken, Tobias Goris, Torsten Schubert, Gabriele Diekert, Nico Jehmlich, Martin von Bergen
Organohalide respiration (OHR), comprising the reductive dehalogenation of halogenated organic compounds, is subject to a unique memory effect and long-term transcriptional downregulation of the involved genes in Sulfurospirillum multivorans. Gene expression ceases slowly over approximately 100 generations in the absence of tetrachloroethene (PCE). However, the molecular mechanisms of this regulation process are not understood. We show here that Sulfurospirillum halorespirans undergoes the same type of regulation when cultivated without chlorinated ethenes for a long period of time. In addition, we compared the proteomes of S. halorespirans cells cultivated in the presence of PCE with those of cells long- and short-term cultivated with nitrate as sole electron acceptor. Important OHR-related proteins previously unidentified in S. multivorans include a histidine kinase, a putative quinol dehydrogenase membrane protein, and a PCE-induced porin. Since for some regulatory proteins a posttranslational regulation of activity by lysine acetylations is known, we also analyzed the acetylome of S. halorespirans, revealing that 32% of the proteome was acetylated in at least one condition. The data indicate that the response regulator and the histidine kinase of a two-component system most probably involved in induction of PCE respiration are highly acetylated during short-term cultivation with nitrate in the absence of PCE.SignificanceThe so far unique long-term downregulation of organohalide respiration is now identified in a second species suggesting a broader distribution of this regulatory phenomenon. An improved protein extraction method allowed the identification of proteins most probably involved in transcriptional regulation of OHR in Sulfurospirillum spp. Our data indicate that acetylations of regulatory proteins are involved in this extreme, sustained standby-mode of metabolic enzymes in the absence of substrate. This first published acetylome of Epsilonproteobacteria might help to study other ecologically or medically important species of this clade.

Graphical abstract

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Corrigendum to “Genetically defined variants of toll-like receptors 3, 7 and 9 as phenotype and risk modifier factors for psoriasis” [89 (March (3)) (2018) 301–304]

Publication date: Available online 1 April 2018
Source:Journal of Dermatological Science
Author(s): M. Julià, M. Consuegra-Fernández, A. Guilabert, C. Muñoz, A. Esteve, N. Armiger-Borràs, F. Santiago, M.T. Arias, J. Romaní, C. Ferrándiz, J.M. Carrascosa, E. Pedrosa, M. Alsina-Gibert, F. Lozano, J.M. Mascaró-Galy




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Serine protease inhibitors containing a Kunitz domain: their role in modulation of host inflammatory responses and parasite survival

Publication date: Available online 1 April 2018
Source:Microbes and Infection
Author(s): Mariana T.Q. de Magalhães, Fábio S. Mambelli, Bruno P.O. Santos, Suellen B. Morais, Sergio C. Oliveira
Proteins containing a Kunitz domain have the typical serine protease inhibition function ranging from sea anemone to man. Protease inhibitors play major roles in infection, inflammation disorders and cancer. This review discusses the role of serine proteases containing a Kunitz domain in immunomodulation induced by helminth parasites. Helminth parasites are associated with protection from inflammatory conditions. Therefore, interest has raised whether worm parasites or their products hold potential as drugs for treatment of immunological disorders. Finally, we also propose the use of recombinant SmKI-1 from Schistosoma mansoni as a potential therapeutic molecule to treat inflammatory diseases.



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Acoustic Structure Quantification Versus Point Shear Wave Speed Measurement for the Assessment of Liver Fibrosis in Viral Hepatitis B

Publication date: Available online 30 March 2018
Source:Ultrasound in Medicine & Biology
Author(s): Jianxue Liu, Wei Ren, Hong Ai, Guoliang Dun, Yonghao Ji, Yaoren Zhang, Qinyun Wan, Shumei Lin
This study was conducted to evaluate the value of acoustic structure quantification (ASQ) technology versus that of point shear wave speed measurement (PSWSM) imaging technology for the assessment of liver fibrosis stage. A total of 104 patients with chronic hepatitis B (CHB) and 30 healthy control patients underwent ASQ and PSWSM examinations. Seven quantitative parameters were obtained from ASQ, and a principal component analysis was used to establish the integrative indicators. A quantitative parameter, known as the shear wave speed (SWS, m/s), was obtained from the PSWSM. The METAVIR scores for the assessment of pathologic liver fibrosis were used as a benchmark. Liver fibrosis stages exhibited a good correlation with the integrative indicators and SWS (r = 0.682, p < 0.001; r = 0.651, p < 0.001). The areas under the receiver operating characteristic curves for ASQ and PSWSM were 0.705 and 0.854 for mild liver fibrosis (F ≥ 1, p = 0.045), 0.813 and 0.743 for significant liver fibrosis (F ≥ 2, p = 0.115), 0.839 and 0.857 for severe liver fibrosis (F ≥ 3, p = 0.417) and 0.874 and 0.971 for liver cirrhosis (F = 4, p = 0.016), respectively. In conclusion, both ASQ and PSWSM were promising ultrasonic methods for assessing liver fibrosis in patients with CHB; however, PSWSM was more valuable for identifying mild liver fibrosis (F ≥ 1) and cirrhosis (F = 4) than ASQ, and the combination of PSWSM and ASQ improved the accuracy of diagnosing severe liver fibrosis (F ≥ 3).



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Consistency and Generalizability of Dietary Patterns in a Multiethnic Working Population

Publication date: Available online 1 April 2018
Source:Journal of the Academy of Nutrition and Dietetics
Author(s): Jui-Yee Eng, Foong-Ming Moy, Awang Bulgiba, Sanjay Rampal
BackgroundDietary pattern analysis is a complementary method to nutrient analysis in evaluating overall diet–disease hypotheses. Although studies have been conducted to derive dietary patterns among Malaysians, their consistency across subgroups has not been examined.ObjectiveThe study aimed to derive dietary patterns empirically and to examine the consistency and generalizability of patterns across sex, ethnicity, and urban status in a working population.DesignThis was a cross-sectional study using data from the Clustering of Lifestyle Risk Factors and Understanding its Association with Stress on Health and Well-Being among School Teachers in Malaysia study collected between August 2014 and November 2015. Dietary intake was assessed using a food frequency questionnaire, and dietary patterns were derived using factor analysis.Participants/settingParticipants were teachers from selected public schools from three states in Peninsular Malaysia (n=4,618).Main outcome measuresDietary patterns derived using factor analysis.Statistical analyses performedSeparate factor analysis was conducted by sex, ethnicity, and urban status to identify dietary patterns. Eigenvalue >2, scree plot, Velicer's minimum average partial analysis, and Horn's parallel analysis were used to determine the number of factors to retain. The interpretability of each dietary pattern was evaluated. The consistency and generalizability of dietary patterns across subgroups were assessed using the Tucker congruence coefficient.ResultsThere was no subgroup-specific dietary pattern found. Thus, dietary patterns were derived using the pooled sample in the final model. Two dietary patterns (Western and Prudent) were derived. The Western dietary pattern explained 15.4% of total variance, characterized by high intakes of refined grains, animal-based foods, added fat, and sugar-sweetened beverages as well as fast food. The Prudent dietary pattern explained 11.1% of total variance and was loaded with pulses, legumes, vegetables, and fruits.ConclusionsThe derived Western and Prudent dietary patterns were consistent and generalizable across subgroups of sex, ethnicity, and urban status. Further research is needed to explore associations between these dietary patterns and chronic diseases.



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Exercise after Aortic Dissection: to Run or Not to Run

Publication date: Available online 31 March 2018
Source:European Journal of Vascular and Endovascular Surgery
Author(s): Konstantinos Spanos, Nikolaos Tsilimparis, Tilo Kölbel




https://ift.tt/2GK4zf9

Scholar : These new articles for Journal of Architectural Conservation are available online

The online platform for Taylor & Francis Online content New for Journal of Architectural Conservation and online now on Taylor & Francis Online: Original Articles The impact of window control on thermal performance. Investigating adaptable interventions in vernacular Mediterranean heritage Stavroula Thravalou, Maria Philokyprou & Aimilios Michael Pages: 1-19 | DOI: 10.1080/13556207.2018.1456058 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Cosmetics, Vol. 5, Pages 26: Rice Water: A Traditional Ingredient with Anti-Aging Efficacy

Cosmetics, Vol. 5, Pages 26: Rice Water: A Traditional Ingredient with Anti-Aging Efficacy

Cosmetics doi: 10.3390/cosmetics5020026

Authors: Joana Marto Ângela Neves Lídia Gonçalves Pedro Pinto Cristina Almeida Sandra Simões

The skin healing benefits of rice have been known for centuries. Rice (Oryza sativa) water is a food processing waste that can potentially be incorporated into cosmetic formulations. However, no scientific evidence supports their role in skincare products. The aim of this project is to design and develop a topical gel formulation containing rice water and to evaluate its biological properties, namely, the anti-aging and antioxidant rice water properties. Rice water was evaluated in terms of physico-chemical composition and in terms of in vitro biological antioxidant activity and elastase inhibitory effect. Rice water was incorporated into a hydrogel and the developed formulation was subjected to pharmacotechnical tests such as pH and viscosity. Biological and sensory effects were evaluated on a panel of 12 volunteers for 28 days. The safety evaluation study was performed on rice water gel, using the Human Repeat Insult Patch test protocol. Rice water presented in vitro biological antioxidant activity and elastase inhibitory effect. The gel formulation containing 96% rice water was biocompatible with the human skin and presented suitable cosmetic properties. Rice water should be thus considered as an anti-aging ingredient to be used as raw material for skincare applications.

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Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG

Publication date: Available online 31 March 2018
Source:Neuroscience Research
Author(s): Yuki Ogawa, Junji Yamaguchi, Masato Yano, Yasuo Uchiyama, Hirotaka James Okano
Alternative splicing of RNAs diversifies the functionalities of proteins, and it is optimized for each cell type and each developmental stage. nElavl (composed of Elavl2, Elavl3, and Elavl4) proteins are the RNA-binding proteins that is specifically expressed in neurons, regulate the alternative splicing of target RNAs, and promote neuronal differentiation and maturation. Recent studies revealed that Elavl3 knockout (Elavl3^−/−) mice completely lost the expression of nElavl proteins in the Purkinje cells and exhibited cerebellar dysfunction. Here, we found that the alternative splicing of AnkyrinG exon 34 was misregulated in the cerebella of Elavl3^−/− mice. AnkyrinG is an essential factor for the formation of neuronal polarity and is required for normal neuronal functions. We revealed that exon 34 of AnkyrinG was normally included in immature neurons and was mostly excluded in mature neurons; however, it was included in the cerebella of Elavl3^−/− mice even in adulthood. In the Purkinje cells of adult Elavl3^−/− mice, the length of the AnkyrinG-positive region shortened and somatic organelles leaked into the axons. These results suggested that exon 34 of AnkyrinG is an embryonic-stage-preferential exon that should be excluded from mature neurons and that Elavl3 regulates neuronal polarity through alternative splicing of this exon.



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Editorial Board

Publication date: May 2018
Source:Research in Developmental Disabilities, Volume 76





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Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits

Publication date: June 2018
Source:Current Opinion in Neurobiology, Volume 50
Author(s): Sabrina Sun, David V Schaffer
Optimization of traditional replication-competent viral tracers has granted access to immediate synaptic partners of target neuronal populations, enabling the dissection of complex brain circuits into functional neural pathways. The excessive virulence of most conventional tracers, however, impedes their utility in revealing and genetically perturbing cellular function on long time scales. As a promising alternative, the natural capacity of adeno-associated viral (AAV) vectors to safely mediate persistent and robust gene expression has stimulated strong interest in adapting them for sparse neuronal labeling and physiological studies. Furthermore, increasingly refined engineering strategies have yielded novel AAV variants with enhanced target specificity, transduction, and retrograde trafficking in the CNS. These potent vectors offer new opportunities for characterizing the identity and connectivity of single neurons within immense networks and modulating their activity via robust delivery of functional genetic tools.



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Blue titania turns carbon dioxide into fuel

Publication date: Available online 31 March 2018
Source:Materials Today
Author(s): Cordelia Sealy




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Cheaper fuel cells with nanomaterials

Publication date: Available online 31 March 2018
Source:Materials Today
Author(s): Laurie Donaldson




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MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation

Publication date: 15 July 2018
Source:NeuroImage, Volume 175
Author(s): Hongjiang Wei, Peng Cao, Antje Bischof, Roland G. Henry, Peder E.Z. Larson, Chunlei Liu
Larmor-frequency shift or image phase measured by gradient-echo sequences has provided a new source of MRI contrast. This contrast is being used to study both the structure and function of the brain. So far, phase images of the brain have been largely obtained at long echo times as maximum phase signal-to-noise ratio (SNR) is achieved at TE = T2* (∼40 ms at 3T). The structures of the brain, however, are compartmentalized and complex with a wide range of signal relaxation times. At such long TE, the short-T2 components are largely attenuated and contribute minimally to phase contrast. The purpose of this study was to determine whether proton gradient-echo images of the brain exhibit phase contrast at ultra-short TE (UTE). Our data showed that UTE images acquired at 7 T without off-resonance saturation do not contain significant phase contrast between gray and white matter. However, UTE images of the brain can attain strong phase contrast even at a nominal TE of 106 μs by using off-resonance RF saturation pulses, which provide direct saturation of ultra-short-T2 components and indirect saturation of longer-T2 components via magnetization transfer. In addition, phase contrast between gray and white matter acquired at UTE with off-resonance saturation is reversed compared to that of the long-T2 signals acquired at long TEs. This finding opens up a potential new way to manipulate image phase contrast of the brain. By accessing short and ultra-short-T2 species, MRI phase images may further improve the characterization of tissue microstructure in the brain.

Graphical abstract

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Castanea mollissima shell prevents an over expression of inflammatory response and accelerates the dermal wound healing

Publication date: 28 June 2018
Source:Journal of Ethnopharmacology, Volume 220
Author(s): Pei Luo, Xinjie Li, Yujie Ye, Xiang Shu, Jiaojiao Gong, Jianping Wang
Ethnopharmacological relevanceCastanea mollissima shell (CMS) has been used for wound healing in China as traditional medicine. The shell is directly applied on the wounded skin as fine powder or as water maceration.Aim of the studyTo investigate the wound healing activity of CMS and the potential mechanism of anti-inflammatory activity.Materials and methodsThe effects of ethanol extract of CMS (ECMS) on nitricoxide (NO), tumor necrosis factor (TNF)-α and interleukin (IL)− 6 productions in lipopolysaccharide (LPS)-treated RAW 264.7 cells were explored by enzyme linked immunosorbent assay (ELISA) in vitro. To study wound healing properties of ECMS in vivo, excision and incision wound models were performed on rats. Inflammatory cytokines from wound biopsies such as NO, TNF-α and IL-6 production were tested by ELISA. mRNA levels of iNOS, cyclooxygenase (COX) −2 and TNF-α were detected by real-time Polymerase Chain Reaction (PCR), and protein levels of IL-1β and Heme Oxygenase (HO) −1 were analyzed by Western blotting.ResultsECMS potently inhibited LPS-induced production of IL-6, NO and TNF-α in RAW 264.7 cells. The presence of quercetin, kaempferol, ursolic acid and gallic acid in ECMS might be responsible for its anti-inflammatory activity. 3% and 5% w/w ECMS significantly accelerated the wound healing process in both wound models, evidenced by the faster rate of wound contraction, epithelialization, increased hydroxyproline content, high tensile strength, decreased level of inflammatory markers compared to the control group. Histopathological studies also revealed the amelioration of wound healing by re-epithelialization, collagenation and vascularization of wounded skin sample in ECMS treated groups.ConclusionThe experimental data revealed that CMS had ability to prevent exaggerated inflammation and accelerates wound epithelialization and might be beneficial for healing dermal wounds.

Graphical abstract

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Data on social media use related to age, gender and trust constructs of integrity, competence, concern, benevolence and identification

Publication date: June 2018
Source:Data in Brief, Volume 18
Author(s): Gillian Warner-Søderholm, Andy Bertsch, Annika Søderholm
This article contains data collected from self-report surveys of respondents to measure 1) social media usage, 2) age, 3) gender and 4) trust, measured within five major trust constructs of a) Integrity, b) Competence, c) Concern, d) Benevolence and e) Identification. The data includes all instruments used, SPSS syntax, the raw survey data and descriptive statistics from the analyses. Raw data was entered into SPSS software and scrubbed using appropriate techniques in order to prepare the data for analysis. We believe that our dataset and instrument may give important insights related to computers in human behavior, and predicting trust antecedents in social media use such as age, gender, number of hour online and choice of content provider. We have also created a parsimonious five factor trust instrument developed from the extant literature for future research. Hence, this newly developed trust instrument can be used to measure trust not only in social media, but also in other areas such as healthcare, economics and investor relations, CSR, management and education. Moreover, the survey items developed to measure social media use are concise and may be applied to measure social media use in other contexts such as national cultural differences, marketing and tourism. For interpretation and discussion of the data and constructs, please see original article entitled "Who trusts social media" (Warner-Søderholm et al., 2018) [1].



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Transcription profile data of phorbol esters biosynthetic genes during developmental stages in Jatropha curcas

Publication date: June 2018
Source:Data in Brief, Volume 18
Author(s): Nurul Jadid, Rizal Kharisma Mardika, Kristanti Indah Purwani, Erlyta Vivi Permatasari, Indah Prasetyowati, Mohammad Isa Irawan
Jatropha curcas is currently known as an alternative source for biodiesel production. Beside its high free fatty acid content, J. curcas also contains typical diterpenoid-toxic compounds of Euphorbiaceae plant namely phorbol esters. This article present the transcription profile data of genes involved in the biosynthesis of phorbol esters at different developmental stages of leaves, fruit, and seed in Jatropha curcas. Transcriptional profiles were analyzed using reverse transcription-polymerase chain reaction (RT-PCR). We used two genes including GGPPS (Geranylgeranyl diphospate synthase), which is responsible for the formation of common diterpenoid precursor (GGPP) and CS (Casbene Synthase), which functions in the synthesis of casbene. Meanwhile, J. curcas Actin (ACT) was used as internal standard. We demonstrated dynamic of GGPPS and CS expression among different stage of development of leaves, fruit and seed in Jatropha.



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Key gene co-expression modules and functional pathways involved in the pathogenesis of Graves’ disease

Publication date: Available online 31 March 2018
Source:Molecular and Cellular Endocrinology
Author(s): Xiaoqing Shao, Bin Wang, Kaida Mu, Ling Li, Qian Li, Weiwei He, Qiuming Yao, Xi Jia, Jin-an Zhang
Graves' disease (GD) is a common autoimmune thyroid disease characterized by positive thyroid stimulating hormone receptor antibody. To better understand its molecular pathogenesis, we adopted the weighted gene co-expression network analysis to reveal co-expression modules of key genes involved in the pathogenesis of GD, protein-protein interaction network analysis to identify the hub genes related to GD development and functional analyses to explore their possible functions. Our results showed that 1) a total of 2667 differentially expressed genes in our microarray study and 16 different gene co-expression modules were associated with GD, and 2) the most significant module was associated with the percentage of macrophages, T follicular helper cells and CD4⁺ memory T cells and mainly enriched in immune regulation and immune response. Overall, our study reveals several key gene co-expression modules and functional pathways involved in GD, which provides some novel insights into the pathogenesis of GD.



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Maternal lipopolysaccharide exposure results in glucose metabolism disorders and sex hormone imbalance in male offspring

Publication date: Available online 1 April 2018
Source:Molecular and Cellular Endocrinology
Author(s): Mei Zhao, Li Yuan, Man-man Yuan, Li-li Huang, Chang Su, Yuan-hua Chen, Yu-ying Yang, Yan Hu, De-xiang Xu
An adverse intrauterine environment may be an important factor contributing to the development of type 2 diabetes in later life. The present study investigated the longitudinal effects of maternal lipopolysaccharide (LPS) exposure during the third trimester on glucose metabolism and sex hormone balance in the offspring. Pregnant mice were intraperitoneally injected with LPS (50 μg/kg) daily from gestational day (GD) 15 to GD17. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were assessed at postnatal day (PND) 60 and PND120. Sex hormones, their receptors, and metabolic enzymes (aromatase) were measured in male offspring at different phases of development (PND14: juvenile; PND35: adolescence; PND60: adulthood; and PND120: middle age). LPS-exposed male offspring exhibited glucose intolerance and insulin resistance by GTT and ITT at middle age, accompanied by an increase in fasting blood glucose and reductions in serum insulin levels and hepatic phosphorylated (p) -AKT/AKT ratio. However, glucose intolerance and insulin resistance were not observed in LPS-exposed female offspring. Maternal LPS exposure upregulated hepatic aromatase proteins and mRNA levels in male offspring at all time points. At adolescence, the testosterone/estradiol ratio (T/E2) was markedly reduced in LPS-exposed male offspring. Moreover, maternal LPS exposure significantly increased hepatic estrogen receptor (ER) α expressions and decreased hepatic androgen receptor (AR) expressions in male offspring. At adulthood, maternal LPS exposure increased serum estradiol levels, decreased serum testosterone levels and elevated hepatic ERβ expressions in male offspring. In conclusion, maternal LPS exposure upregulated aromatase expressions, followed by a reduction in the T/E2 ratio and an alteration in sex hormone receptor activity, which might be involved in the development of glucose metabolism disorders in middle-aged male offspring. This study provides a novel clue and direction to clarify the pathogenesis of maternal infection-related diabetes in male offspring.



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Scholar : Chinese Archives of Otolaryngology-Head and Neck Surgery, Year 2018, Issue 01 -New Issue Alert.

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Archives of Otolaryngology-Head and Neck Surgery. Year 2018 Issue 01 is now available on CAOD. In this issue: guo min xing bi yan pi xia mian yi zhi liao de lin chuang cao zuo gui fan (过敏性鼻炎皮下免疫治疗的临床操作规范) ...... page:1-12 li tui you zhi zi yuan xia chen zhu li ji ceng fu wu ti sheng bei jing tong ren yi yuan qian tou cheng li quan guo er bi yan hou tou jing wai ke lian meng (力推优质资源下沉 助力基层服务提升 北京同仁医院牵头成立全国耳鼻咽喉头颈外科联盟) ZHAO Liming ...... page:8 Expression of multiple target microRNA of nasopharyngeal carcinoma susceptible TERT gene in nasopharyngeal carcinoma patients and its clinical value (鼻咽癌易感TERT基因的多种靶microRNA在鼻咽癌患者血清中表达量变化及其临床诊断价值) ZHANG Kai, WANG Jianhong, LUO Xiaozou, Department of Otolaryngology, the First People's Hospital of Yibin ...... page:13-16 Preliminary study on the construction of CAR-EGFR modified T cells(EGFR-CART) in hypopharyngeal squamous cell carcinoma (下咽鳞状细胞癌CAR-EGFR修饰T细胞构建的初步研究) ZHANG Yang, DING Yiming, ZHONG Qi, CHEN Xuejun, LI Pingdong, FANG Jugao, CHEN Xiaohong, HUANG Zhigang, Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education ...... page:17-21 yu ci zhi you zuo xia yan xing rou ya zhong ban nong zhong 1 li (鱼刺致右颌下炎性肉芽肿伴脓肿1例) QU Xiaoli, LIU Xiaoling, WANG Xiaolei, ZHANG Shuxiang, LIU Ping ...... page:22 Analysis of clinical characteristics of subjective tinnitus in patients with perimenopausal syndrome (伴围绝经期综合征的主观性耳鸣患者临床特征分析) LI Huifeng, GUO Lifang, LIU Ping, ZENG Xiaomei, ZHU Zhongshou, WEI Rifu, Department of Otolaryngology Head and Neck Surgery, Ningde Institute of Otolaryngology, Ningde Affiliated Hospital of Fujian Medical University, Department of Gynaecology and Obstetrics, Ningde Affiliated Hospital of Fujian Medical University ...... page:23-26 Salicylate-induced changes of synaptic ultrastructures in the rat auditory center: a pilot study (水杨酸盐对大鼠听觉中枢超微结构影响的初步研究) YI Bin, SHI Runjie, WU Cong, HUANG Zhiwu, WU Hao, Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Ear Institute Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases ...... page:27-30 Noise-induced acetyl-histone H2B expression alteration in marginal cell of stria vascularis and spiral ganglion cell of cochlear (噪声对耳蜗边缘细胞及螺旋神经节细胞乙酰化组蛋白H2B的影响) YANG Denghua, GONG Shusheng, XIE Jing, CHEN Liyan, Department of Otolaryngology Head and Neck Surgery, Fuxing Hospital, Capital Medical University, Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University ...... page:31-34 Association of interleukin-10 gene polymorphism with bronchial asthma in Chinese subjects in Beijing area (白细胞介素10基因多态性与北京地区哮喘病患者的相关性研究) ZHANG Xu, WANG Yuhong, ZHANG Yuan, ZHANG Luo, Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Beijing Key Laboratory of Nasal Diseases, Department of Respiratory, Beijing Tongren Hospital, Capital Medical University ...... page:35-37 Clinical application of the modified scalp coronal incision in the treatment of zygomatic complex fractures (改良头皮冠状切口在治疗颧骨复杂性骨折中的临床应用) LI Shuhua, GUAN Jian, ZHANG Yujun, ZHU Huaming, LIU Suru, YI Hongliang, DENG Wei, Department of Otolaryngology of Mian Yang Central Hospital, Department of Otolaryngology, Sixth Hospital Affiliated to Shanghai Jiaotong University, Otolaryngology Institute of Medical College of Shanghai Jiao Tong University ...... page:38-40 Effect of fixation of the pipe on air leakage in continuous positive airway pressure treatment (持续正压通气治疗中管路固定对漏气量的影响) KANG Dan, XU Wen, DING Xiu, WANG Chunyan, LI Hongguang, Sleep Medicine Center, Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University ...... page:41-43 man xing fen mi xing zhong er yan liang zhong zhi liao fang an bi jiao (慢性分泌性中耳炎两种治疗方案比较) XU Yuzhou, YIN Zhijun, LIU Fang, ZHANG Huimin ...... page:44-46 ying you er shi qi fa xian de dan er ji zhong du long huan er de lin chuang te zheng fen xi (婴幼儿时期发现的单耳极重度聋患儿的临床特征分析) ZHOU Cailing, JIA Yuezhi, LI Jing, WANG Chengzuo, HU Zuying, PAN Pingping, BIAN Yangpu ...... page:47-48 wei bo zhi liao li te er qu bi chu xue zhi bi zhong ge ruan gu huai si lin chuang fen xi (微波治疗利特尔区鼻出血致鼻中隔软骨坏死临床分析) WANG Jinyu ...... page:49-50 2018 nian ben kan zhi jie shi yong suo lue yu de yi xue ci hui (2018年本刊直接使用缩略语的医学词汇) ...... page:50 xiao er qi guan cha guan hou hou qi guan xia zhai lin chuang fen xi (小儿气管插管后喉气管狭窄临床分析) LI Zuozuo, DENG Minzuo, LU Zhongming, SHENG Xiaoli, ZHANG Siyi ...... page:51-52 bian ying xing bi yan te yi xing mian yi zhi liao yan jiu jin zhan (变应性鼻炎特异性免疫治疗研究进展) LIU Zuozuo, ZHENG Jun, ZHU Dongdong, MENG Cuida ...... page:53-56 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service