Scholar : International Journal of Heritage Studies, Volume 24, Issue 9, October 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content International Journal of Heritage Studies, Volume 24, Issue 9, October 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Original Articles Conceptualising the subjective authenticity of intangible cultural heritage Junjie Su Pages: 919-937 | DOI: 10.1080/13527258.2018.1428662 The inherent malleability of heritage: creating China's beautiful villages Toby Lincoln & Rebecca Madgin Pages: 938-953 | DOI: 10.1080/13527258.2018.1428666 Socialist architecture as today's dissonant heritage: administrative buildings of collective farms in Estonia Laura Ingerpuu Pages: 954-968 | DOI: 10.1080/13527258.2018.1428664 Miniature dissonance and the museum space: reconsidering communication through miniaturisation Jack William Davy Pages: 969-983 | DOI: 10.1080/13527258.2018.1428669 The tourism and local development in world heritage context. The case of the Mayan site of Palenque, Mexico Amilcar Vargas Pages: 984-997 | DOI: 10.1080/13527258.2018.1428670 Heritage destruction and cultural rights: insights from Bagan in Myanmar Anne-Laura Kraak Pages: 998-1013 | DOI: 10.1080/13527258.2018.1430605 Book Review Tokyo vernacular: common spaces, local histories, found objects Henry Johnson Pages: 1014-1015 | DOI: 10.1080/13527258.2018.1440620 Topographies of memories: a new poetics of commemoration Ross J. Wilson Pages: 1016-1017 | DOI: 10.1080/13527258.2018.1440619 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies

Background/Aims: This study aimed to investigate transfollicular delivery enhancement of caffeine from nanoemulsion formulations incorporating oleic acid (OA) and eucalyptol (EU) as chemical penetration enhancers. Methods: Caffeine permeation was evaluated from nanoemulsions containing OA or EU and an aqueous control solution through excised human full-thickness skin with hair follicles opened, blocked, or left untreated. Differential tape stripping was performed, followed by cyanoacrylate skin surface biopsies to determine the amount of caffeine in the hair follicles, and skin extraction to determine the retention of caffeine in the skin. Results: Nanoemulsions significantly increased caffeine permeation through open and untreated skin over control (untreated: 36- and 42-fold for OA and EU, respectively; open: 40- and 49-fold). The follicular route contributed 53.7% of caffeine permeation for the OA nanoemulsion and 51% for EU when follicles were opened. Nanoemulsions promoted 4- and 3.4-fold increases in caffeine retention in open follicles, for OA and EU, respectively. Retention of caffeine in the stratum corneum and skin was almost equal in all cases. Conclusions: This study demonstrated effective delivery of caffeine as a hydrophilic model drug into and through hair follicles and showed that follicles and surrounding regions may be targeted by optimised formulations for specific treatments.
Skin Pharmacol Physiol 2018;31:252–260

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Scholar : These new articles for American Review of Canadian Studies are available online

The online platform for Taylor & Francis Online content New for American Review of Canadian Studies and online now on Taylor & Francis Online: Original Articles Transnational Spatial Dimensions of Colombian–Canadian Relations in the Era of Capitalist Expansionism Stefano Tijerina Pages: 1-18 | DOI: 10.1080/02722011.2018.1489953 Do you have original research that relates to present-day Japan and its recent historical development? Contemporary Japan welcomes your submissions. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Aphasiology are available online

The online platform for Taylor & Francis Online content New for Aphasiology and online now on Taylor & Francis Online: Review Article A review of lexical retrieval intervention in primary progressive aphasia and Alzheimer's disease: mechanisms of change, generalisation, and cognition Ashleigh Beales, Anne Whitworth & Jade Cartwright Pages: 1-28 | DOI: 10.1080/02687038.2018.1491192 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Issue Information

Molecular Oral Microbiology, Volume 33, Issue 4, Page i-iv, August 2018.


https://ift.tt/2udZ8Og

Molecular genetics of tetrahydrobiopterin deficiency in Chinese patients

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2KSWibJ

Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies

Abstract

Brain genetics is an active research area. The degree to which genetic variants impact variations in brain structure and function remains largely unknown. We examined the heritability of regional brain volumes (P ~ 100) captured by single-nucleotide polymorphisms (SNPs) in UK Biobank (n ~ 9000). We found that regional brain volumes are highly heritable in this study population and common genetic variants can explain up to 80% of their variabilities (median heritability 34.8%). We observed omnigenic impact across the genome and examined the enrichment of SNPs in active chromatin regions. Principal components derived from regional volume data are also highly heritable, but the amount of variance in brain volume explained by the component did not seem to be related to its heritability. Heritability estimates vary substantially across large-scale functional networks, exhibit a symmetric pattern across left and right hemispheres, and are consistent in females and males (correlation = 0.638). We repeated the main analysis in Alzheimer's Disease Neuroimaging Initiative (n ~ 1100), Philadelphia Neurodevelopmental Cohort (n ~ 600), and Pediatric Imaging, Neurocognition, and Genetics (n ~ 500) datasets, which demonstrated that more stable estimates can be obtained from the UK Biobank.

https://ift.tt/2JePsI0

Audio-Tactile and Peripersonal Space Processing Around the Trunk in Human Parietal and Temporal Cortex: An Intracranial EEG Study

Abstract

Interactions with the environment happen within one's peripersonal space (PPS)—the space surrounding the body. Studies in monkeys and humans have highlighted a multisensory distributed cortical network representing the PPS. However, knowledge about the temporal dynamics of PPS processing around the trunk is lacking. Here, we recorded intracranial electroencephalography (iEEG) in humans while administering tactile stimulation (T), approaching auditory stimuli (A), and the 2 combined (AT). To map PPS, tactile stimulation was delivered when the sound was far, intermediate, or close to the body. The 19% of the electrodes showed AT multisensory integration. Among those, 30% showed a PPS effect, a modulation of the response as a function of the distance between the sound and body. AT multisensory integration and PPS effects had similar spatiotemporal characteristics, with an early response (~50 ms) in the insular cortex, and later responses (~200 ms) in precentral and postcentral gyri. Superior temporal cortex showed a different response pattern with AT multisensory integration at ~100 ms without a PPS effect. These results, represent the first iEEG delineation of PPS processing in humans and show that PPS and multisensory integration happen at similar neural sites and time periods, suggesting that PPS representation is based on a spatial modulation of multisensory integration.

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Synaptic Mechanisms for Bandwidth Tuning in Awake Mouse Primary Auditory Cortex

Abstract

Spatial size tuning in the visual cortex has been considered as an important neuronal functional property for sensory perception. However, an analogous mechanism in the auditory system has remained controversial. In the present study, cell-attached recordings in the primary auditory cortex (A1) of awake mice revealed that excitatory neurons can be categorized into three types according to their bandwidth tuning profiles in response to band-passed noise (BPN) stimuli: nonmonotonic (NM), flat, and monotonic, with the latter two considered as non-tuned for bandwidth. The prevalence of bandwidth-tuned (i.e., NM) neurons increases significantly from layer 4 to layer 2/3. With sequential cell-attached and whole-cell voltage-clamp recordings from the same neurons, we found that the bandwidth preference of excitatory neurons is largely determined by the excitatory synaptic input they receive, and that the bandwidth selectivity is further enhanced by flatly tuned inhibition observed in all cells. The latter can be attributed at least partially to the flat tuning of parvalbumin inhibitory neurons. The tuning of auditory cortical neurons for bandwidth of BPN may contribute to the processing of complex sounds.

https://ift.tt/2LekUI2

Effects of Nd:YAG low-level laser irradiation on cultured human osteoblasts migration and ATP production: in vitro study

Abstract

Low-level laser therapy has become one of the fastest growing fields of medicine in recent years. Many in vivo and in vitro studies have shown that laser irradiation activates a range of cellular processes in a variety of cell types and can promote tissue repair. However, few in vitro experiments have evaluated the effects of laser irradiation on cells in real time. The purpose of this study was to examine the effects of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser irradiation on the migration of cultured human osteoblasts. A dedicated 96-well plate was used, and confluent cultures of the human osteoblast-like cell line, Saos-2, were injured with a wound maker. The wounded cells were then exposed to the Nd:YAG laser (wavelength of 1064 nm) for 60 s at 0.3 W (10 pps, 30 mJ). The total energy density was about 10.34 J/cm². Images of the wounds were automatically acquired inside the CO₂ incubator by the IncuCyte ZOOM™ software. In addition, after laser irradiation, the production of adenosine triphosphate (ATP) was measured using the CellTiter-Glo™ Luminescent Cell Viability Assay. Migration of cells from the border of the original scratch zone was accelerated by laser irradiation. In addition, compared with the control group, significant enhancement of ATP production was observed in the irradiated group. The present study showed that Nd:YAG laser irradiation (wavelength of 1064 nm, 0.3 W, 10 pps, 30 mJ, 10.34 J/cm², irradiation time 60 s) may contribute to the regeneration of bone tissues owing to enhanced osteoblast cell migration.

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Issue Information

Helicobacter, Volume 23, Issue 4, August 2018.


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Phase II study of accelerated Linac-based SBRT in five consecutive fractions for localized prostate cancer

Abstract

Aim

The goal was to evaluate feasibility, side effects and biochemical no evidence of disease (bNED) after stereotactic body radiation therapy (SBRT) delivered on 5 consecutive days for localized prostate cancer (PC).

Methods

The study was approved by the ethical committee and started in March 2014. Inclusion criteria were age ≤85 years, WHO performance status ≤2, histologically proven adenocarcinoma, low–intermediate risk, no previous surgery (except transurethral resection of the prostate), and a pre-SBRT International Prostatic Symptoms Score of 0–7. The radiotherapy regimen consisted of 35 Gy for low-risk and 37.5 Gy for intermediate-risk PC in 5 consecutive fractions.

Results

At the time of the analysis, 52 patients were recruited to the study (median age 73 years, range 55–83 years; median follow-up 34 months, range 12–49 months; 34 patients low-risk and 18 intermediate risk). The median initial prostate-specific antigen (PSA) was 5.9 ng/ml (range 1.8–15.7). Acute genitourinary (GU) toxicity was G0 (grade 0) 36/52 (69%), G1 11/52 (21%), G2 5/52 (10%), while acute rectal (GI) toxicity was G0 43/52 (83%), G1 8/52 (15%), G2 1/52 (2%). No acute toxicity ≥G3 was recorded. At the time of analysis late GU and GI toxicities were as follows: GU-G0 43/52 (83%), GU-G1 7/52 (13%), GU-G2 2/52 (4%); GI-G0 48/52 (92%), GI-G1 2/52 (4%), GI-G2 2/52 (4%). No late toxicities ≥G3 were recorded. bNED was 98%. One patient with intermediate PC had distant progression.

Conclusions

Accelerated SBRT for low-intermediate PC is feasible and well tolerated with comparable oncological outcome as described for other series with the same RT technique but treatment delivery on every other day. Longer follow-up is needed to the assess late toxicity profile and long-term clinical outcome.

https://ift.tt/2JgNoyZ

Psoriasis and cancer. An Australian/New Zealand narrative

Australasian Journal of Dermatology, EarlyView.


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Exome sequencing identifies novel compound heterozygous mutations in GJB3 gene that cause erythrokeratodermia variabilis et progressiva

Australasian Journal of Dermatology, EarlyView.


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Liver Biochemical Abnormalities in Turner Syndrome: a Comprehensive Characterisation of an Adult Population

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2N9zX6F

Inter‐related effects of insulin resistance, hyperandrogenism, sympathetic dysfunction and chronic inflammation in PCOS

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KTvxEl

Hiding in a plain sight: a high prevalence of androgen deficiency due to primary hypogonadism among acute medical inpatients with anaemia

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2N6xMk2

Thyroid Storm and Complete Heart Block after Treatment with Radioactive Iodine.

Related Articles

Thyroid Storm and Complete Heart Block after Treatment with Radioactive Iodine.

Case Rep Endocrinol. 2018;2018:8214169

Authors: Vennard K, Gilbert MP

Abstract
Thyroid storm is a rare endocrine emergency characterized by dysfunction of multiple organ systems. Thyroid storm is more common in Graves' disease and can be precipitated by surgery, trauma, infection, metabolic abnormalities, iodine load, and parturition. We present a diagnostically challenging case of thyroid storm precipitated by radioiodine therapy and accompanied by bradycardia, a rare but life-threatening complication related to treatment for hyperthyroidism.

PMID: 29992062 [PubMed]

https://ift.tt/2NI6cuN

Role of AMPA and NMDA receptors on vasopressin and oxytocin secretion induced by hypertonic extracellular volume expansion

Journal of Neuroendocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2JgG72c

EEMCO—European group on efficacy measurement and evaluation of cosmetics and other products

Skin Research and Technology, Volume 24, Issue 3, Page 349-350, August 2018.


https://ift.tt/2L3AEAY