Functional variant of CHI3L1 gene is associated with neck metastasis in oral cancer

Abstract

Objectives

Oral cancer is the most common head and neck malignancy, and it is associated with a high recurrence rate and lymph node metastasis potential. YKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein that serves as a biomarker in several diseases. It also plays a crucial role in regulating many characteristics of cancer, such as cell growth, migration, anti-apoptosis, and angiogenesis. Accumulating evidence supports the link between single-nucleotide polymorphisms (SNPs) and oral cancer, but no report on the association between CHI3L1 polymorphisms and oral cancer is available. Thus, the present study evaluated the contribution of CHI3L1 SNPs to oral cancer susceptibility and clinicopathology.

Materials and methods

This study recruited a total of 2362 subjects, comprising 1190 healthy male controls and 1172 male patients with oral cancer. Allelic discrimination of the CHI3L1 polymorphisms − 1371 G>A (rs6691378), − 247 G>A (rs10399805), − 131 C>G (rs4950928), and + 2950 T>C (rs880633) was assessed through real-time polymerase chain reaction.

Results

We detected a significant association of rs10399805 and rs6691378 with the risk of oral cancer (AOR, 1.537; 95% CI, 1.089–2.168; p = 0.014; AOR, 1.561; 95% CI, 1.131–2.156; p = 0.007, respectively) after adjustment for three potential confounders, smoking, betel nut chewing, and alcohol consumption. Moreover, we found that oral cancer patients carrying the homozygous A/A genotype of the rs10399805 (p = 0.035) or rs6691378 polymorphism (p = 0.023) showed a significantly lower risk of lymph node metastasis. Moreover, according to the Genotype-Tissue Expression database, the rs10399805 and rs6691378 polymorphisms in the promoter region were associated with decreased levels of CHI3L1 mRNA.

Conclusions

In conclusion, we found that the homozygous mutant allele of rs10399805 and rs6691378 appeared to have significantly lower risk of lymph node metastasis and associated with its mRNA levels in oral cancer.

Clinical relevance

The CHI3L1 polymorphisms rs10399805 and rs6691378 may act as biomarkers for predicting lymph node metastasis in oral cancer patients.

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Atezolizumab Plus nab-Paclitaxel in the Treatment of Metastatic Triple-Negative Breast Cancer

This phase 1b multicohort study assessed 33 patients with advanced triple-negative breast cancer treated with atezolizumab plus nab-paclitaxel to examine its safety, tolerability, and preliminary clinical activity.

https://ift.tt/2J5Fieg

Pilot Randomized Trial of a Pharmacy Intervention for Older Adults with Cancer

AbstractBackground.Oncology clinicians often struggle with managing medications and vaccinations in older adults with cancer. We sought to demonstrate the feasibility and preliminary efficacy of integrating pharmacists into the care of older adults with cancer to enhance medication management and vaccination administration.Methods.We randomly assigned patients aged ≥65 years with breast, gastrointestinal, or lung cancer receiving first‐line chemotherapy to the pharmacy intervention or usual care. Patients assigned to the intervention met with a pharmacist once during their second or third chemotherapy infusion. We obtained information about patients' medications and vaccinations via patient report and from the electronic health record (EHR) at baseline and week 4. We determined the number of discrepant (difference between patient report and EHR) and potentially inappropriate (Beers Criteria assessed by nonintervention pharmacists blinded to group assignment) medications. We defined the intervention as feasible if >75% of patients enrolled in the study and received the pharmacist visit.Results.From January 17, 2017, to October 27, 2017, we enrolled and randomized 60 patients (80.1% of patients approached). Among those assigned to the intervention, 96.6% received the pharmacist visit. At week 4, intervention patients had higher rates of acquiring vaccinations for pneumonia (27.6% vs. 0.0%, p = .002) and influenza (27.6% vs. 0.0%, p = .002) compared with usual care. Intervention patients had fewer discrepant (5.82 vs. 8.07, p = .094) and potentially inappropriate (3.46 vs. 4.80, p = .069) medications at week 4, although differences were not significant.Conclusion.Integrating pharmacists into the care of older adults with cancer is feasible with encouraging preliminary efficacy for enhancing medication management and improving vaccination rates.Implications for Practice.Results of this study showed the feasibility, acceptability, and preliminary efficacy of an intervention integrating pharmacists into the care of older adults with cancer. Notably, patients assigned to the intervention had fewer discrepant medications and were more likely to acquire vaccinations for pneumonia and influenza. Importantly, this work represents the first randomized controlled trial involving the integration of pharmacists into the outpatient oncologic care of older adults with cancer. In the future, a larger randomized trial is needed to demonstrate the efficacy of this care model to enhance medication management and improve vaccination outcomes for older patients with cancer.

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Sight‐threatening Graves’ orbitopathy: twenty years’ experience of a multidisciplinary thyroid‐eye outpatient clinic

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


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TraceIT Tissue Marker to Mark the Primary Resection Bed Margins of Oropharyngeal Cancers

Condition:   Oropharyngeal Cancer
Intervention:   Device: TraceIT Tissue Marker
Sponsor:   Washington University School of Medicine
Not yet recruiting

https://ift.tt/2CrA9fo

Behavior of the Upper Cervical Spine in Rugby Players

Condition:   Cervical Spine Destabilization
Intervention:   Other: Destabilization of the upper cervical spine by Cervistab
Sponsor:   University Hospital, Montpellier
Recruiting

https://ift.tt/2CXtdaO

Nanoliposomal Irinotecan in Head & Neck and Esophagus After Prior Platinum-based Chemotherapy or Chemoradiotherapy

Condition:   Head & Neck Cancer
Intervention:   Drug: nanoliposomal irinotecan
Sponsors:   National Health Research Institutes, Taiwan;   China Medical University Hospital;   Tri-Service General Hospital;   Taipei Veterans General Hospital, Taiwan;   National Cheng-Kung University Hospital
Not yet recruiting

https://ift.tt/2CsErmC

Safety and Efficacy of SCT200 in Head and Neck Squamous Cell Carcinoma

Condition:   Head and Neck Cancer
Intervention:   Drug: Anti-EGFR monoclonal antibody
Sponsors:   Sinocelltech Ltd.;   Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Not yet recruiting

https://ift.tt/2CSmjUh

Prospective Observational Trial to Evaluate Quality of Life After Neoadjuvant or Definitive Chemoradiation in Patients With Esophageal Cancer

Conditions:   Quality of Life;   Chemoradiation;   Esophageal Cancer
Interventions:   Other: EORTC QLQ C30;   Other: EORTC QLQ OES-18;   Other: EORTC OG-25
Sponsor:   Ludwig-Maximilians - University of Munich
Recruiting

https://ift.tt/2CtES03

Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic Therapy

Conditions:   Cancer;   Esophagus Squamous Cell Carcinoma;   Squamous Cell Carcinoma of the Head and Neck;   Anal Canal Squamous Cell Carcinoma;   Metastatic Cancer
Intervention:  
Sponsor:   University Health Network, Toronto
Not yet recruiting

https://ift.tt/2CUnMtg

Scholar : American Journalism, Volume 35, Issue 3, Summer 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content American Journalism, Volume 35, Issue 3, Summer 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Editorial Editor's Note By Ford Risley Pages: 275 | DOI: 10.1080/08821127.2018.1493313 Articles The Accidental Press Critic: Newsroom Ethnography and Resistance to Self-criticism and Management Change at the New York Times in 1974 By Kevin M. Lerner Pages: 276-297 | DOI: 10.1080/08821127.2018.1491203 The Life Cycle and Conventions of Nineteenth-Century Breaking News: Disaster Reporting of the 1875 Virginia City Fire By Katrina J. Quinn Pages: 298-314 | DOI: 10.1080/08821127.2018.1491204 Poor Richard Revised: Benjamin Franklin and the Ritual Economy of Copyright in Colonial America By Jason Lee Guthrie Pages: 315-333 | DOI: 10.1080/08821127.2018.1491205 Reading Helen Jewett's Murder: The Historiographical Problems and Promises of Journalism Michael Buozis Pages: 334-356 | DOI: 10.1080/08821127.2018.1491206 Professional Notes It Ain't Over 'Til It's Over: Ending (?) the Narrative about the Chicago Tribune and the Battle of Midway Patrick S. Washburn & Michael S. Sweeney Pages: 357-369 | DOI: 10.1080/08821127.2018.1491207 Book Reviews Defending the Masses: A Progressive Lawyer's Battles for Free Speech Pages: 370-372 | DOI: 10.1080/08821127.2018.1491218 Book Review Pages: 372-374 | DOI: 10.1080/08821127.2018.1491223 Across the Waves: How the United States and France Shaped the International Age of Radio Pages: 374-376 | DOI: 10.1080/08821127.2018.1491221 Alone atop the Hill: The Autobiography of Alice Dunnigan, Pioneer of the National Black Press Pages: 376-378 | DOI: 10.1080/08821127.2018.1491224 Future Proofing the News: Preserving the First Draft of History Pages: 378-380 | DOI: 10.1080/08821127.2018.1491227 Race News: Black Journalists and the Fight for Racial Justice in the Twentieth Century Pages: 380-382 | DOI: 10.1080/08821127.2018.1491228 The Essay Film after Fact and Fiction Pages: 382-384 | DOI: 10.1080/08821127.2018.1491230 We Believed We Were Immortal: Twelve Reporters Who Covered the 1962 Integration Crisis at Ole Miss Pages: 384-386 | DOI: 10.1080/08821127.2018.1491229 Digital Media Reviews Billy Ireland Cartoon Library & Museum Mary Spillman Reviewed by Pages: 387-389 | DOI: 10.1080/08821127.2018.1491231 Roy W. Howard Archive Pages: 389-391 | DOI: 10.1080/08821127.2018.1491232 The Museum of Broadcast Communications, Chicago, Illinois Len O'Kelly Pages: 391-393 | DOI: 10.1080/08821127.2018.1491233 Endnotes Endnotes Pages: 394-395 | DOI: 10.1080/08821127.2018.1491208 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Journal of Natural History, Volume 52, Issue 33-34, September - September 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Journal of Natural History, Volume 52, Issue 33-34, September - September 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles The ninth brachypterous Onthophagus Latreille (Coleoptera: Scarabaeidae: Scarabaeinae) of the world: a new species from Mexico Héctor Jaime Gasca Álvarez, Mario Zunino & Cuauhtémoc Deloya Pages: 2121-2132 | DOI: 10.1080/00222933.2018.1515382 The occurrence of facultative paedomorphosis in a lacustrine population of the Pyrenean newt (Calotriton asper): morphology and age structure Sebastià Camarasa, Fèlix Amat, Delfí Sanuy & Neus Oromi Pages: 2133-2145 | DOI: 10.1080/00222933.2018.1516831 Neotropical Lispe (Diptera: Muscidae): notes, redescriptions and key to species João M. Fogaça & Claudio J. B. de Carvalho Pages: 2147-2184 | DOI: 10.1080/00222933.2018.1515380 Across-shore distribution of Ocypode quadrata burrows in relation to beach features and human disturbance Frank A. Ocaña, Alberto De Jesús-Navarrete & Héctor A. Hernández-Arana Pages: 2185-2196 | DOI: 10.1080/00222933.2018.1524030 A new species of Friesea (Collembola: Neanuridae) from the Antarctic Continent Penelope Greenslade Pages: 2197-2207 | DOI: 10.1080/00222933.2018.1523483 New records of two decapod crustaceans (Decapoda: Dendrobranchiata and Pleocyemata) from the Gulf of Mannar, India Vinay P. Padate, Mithila S. Bhat & Chandrashekher U. Rivonker Pages: 2209-2220 | DOI: 10.1080/00222933.2018.1524031 Life history of the Rio Grande leopard frog (Lithobates berlandieri) in Texas Daniel F. Hughes & Walter E. Meshaka, Jr Pages: 2221-2242 | DOI: 10.1080/00222933.2018.1526983 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Platelet‐rich plasma: Potential role in combined therapy for vitiligo

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NQkiZB

Vulvar Cancer Association with Groin Hidradenitis Suppurativa: A Large, Urban, Midwestern U.S. Patient Population Study

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Supriya Rastogi, Kevin R. Patel, Vivek Singam, Yasmeen Ali, Jing Gao, Ahmad Amin, Bethanee J. Schlosser, Dennis P. West, Beatrice Nardone

https://ift.tt/2J6rdNQ

Tumor necrosis factor-alpha inhibitors for the treatment of pyoderma gangrenosum not associated with inflammatory bowel diseases: a multicenter retrospective study

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Laurie Rousset, Adèle de Masson, Edouard Begon, Axel Villani, Maxime Battistella, Michel Rybojad, Marie Jachiet, Martine Bagot, Jean-David Bouaziz, Clémence Lepelletier

https://ift.tt/2OzMkhp

Epidemiology of Nickel Sensitivity: Retrospective Cross-Sectional Analysis of North American Contact Dermatitis Group (NACDG) Data 1994-2014

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Erin M. Warshaw, Amy J. Zhang, Joel G. DeKoven, Howard I. Maibach, Donald V. Belsito, Denis Sasseville, Joseph F. Fowler, Anthony F. Fransway, Toby Mathias, Melanie D. Pratt, James G. Marks, Kathryn A. Zug, Matthew J. Zirwas, James S. Taylor, Vincent A. DeLeo

Abstract

Background

Nickel is a common allergen.

Objective

To examine the epidemiology of nickel sensitivity in North America.

Methods

Retrospective, cross-sectional analysis of 44,097 patients patch tested by the North American Contact Dermatitis Group from 1994-2014. Nickel sensitivity was defined as a positive patch test to nickel. We evaluated frequency of nickel sensitivity and patient demographics. For each positive nickel reaction, we tabulated clinical relevance, occupational relatedness, and exposure sources.

Results

Average frequency of nickel sensitivity was 17.5% (1994-2014). Nickel sensitivity significantly increased over time (14.3% 1994-1996 to 20.1% 2013-2014, p<0.0001). Nickel sensitive patients were significantly more likely to be female, young, non-Caucasian, atopic (eczema and asthma), and/or have dermatitis affecting the face, scalp, ears, neck, arm, or trunk (p values ≤0.0474). Overall, 55.5% of reactions were currently clinically relevant; this frequency significantly increased over time (44.1% 1994-1996 to 51.6% 2013-2014, p<0.0001). Occupational relatedness was 3.7% overall with a significant decrease over time (7.9% 1994-1996 to 1.9% 2013-2014, p<0.0001). Jewelry was the most common source.

Limitations

Tertiary referral population.

Conclusions

Nickel allergy is of significant public health importance in North America. The frequency of nickel sensitivity in patients referred for patch testing has significantly increased over a 20-year period.

https://ift.tt/2J8hK8z

Hydrocolloid Dressing Application for the Treatment of Pediatric Onychodystrophies

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Solomon Geizhals, Christine T. Lauren, Shari R. Lipner

https://ift.tt/2OyqP0n

Antioxidant supplements in combination with phototherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials

Publication date: Available online 18 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Han Mi Jung, Yu Seok Jung, Ji Hae Lee, Gyong Moon Kim, Jung Min Bae

https://ift.tt/2J8hCWD

Credit-card sized field and benchtop NMR relaxometers using field programmable gate arrays

Publication date: Available online 18 October 2018

Source: Magnetic Resonance Imaging

Author(s): J. Beau W. Webber, Pavel Demin

Abstract

The tools for developing systems for NMR improve each year. Some firmware based designs based on Field Programmable Gate Arrays (FPGAs) have been developed to implement both the core and peripheral apparatus for NMR Relaxometers and NMR Cryoporometers. Hand held in size they are particularly suitable for desktop, mobile and field use.

Software tools now enable the writing of firmware that enable the rapid design of digital and digitised R.F. data and control systems. This firmware can then be loaded into and run on hardware that often is only the size of a credit-card. These devices can include a single-chip Linux computer with an FPGA capable of processing digital RF on the same chip. These can generate RF signals digitally, process RF signals for up- and down-conversion, and can provide an on chip NMR pulse sequencer.

An extremely well tested NMR digital transmitter has been upgraded to use the latest surface-mount Bipolar and Field Effect Transistors. The circuitry is now the size of a book of matches, and interfaces to credit-card sized FPGA modules for RF generation, phase shifting and drive signals. This NMR transmitter design uses digital logic principles rather than conventional tuned R.F. techniques Offering both active-damping and active-quench, a very square R.F. Pulse with fast turn off is achieved, with Mark 1 giving 2.6 μs π/2 and 4.8 μs π pulses into a 5 mm diameter NMR sample (2.7 mT B₁) at 20 MHz for Protons. T1ρ pulses are stable and consistent.

https://ift.tt/2JbXHq1

Effect of Physical and Chemical Hair Removal Methods on Skin Barrier Function in vitro: Consequences for a Hydrophilic Model Permeant

Background: Although very common in our society, the effect of hair removal on physiological skin parameters and on the ingress of applied chemicals has not been systematically investigated. Thus, as a first step, the aim of the present study was to elucidate the effect of hair removal through epilation (electric epilation, waxing) and depilation (dry and wet shaving, depilatory cream) on skin properties in vitro using the porcine ear model. Methods: Attenuated total reflection Fourier transform infrared spectroscopy, measurement of the transepidermal water loss (TEWL), visualization by capacitance-based contact imaging, confocal Raman spectroscopy (CRS), diffusion cell studies and tape stripping experiments were employed. Results: Increased TEWL and altered skin permittivity maps were observed. Decreased stratum corneum thickness was observed after waxing. Diffusion cell studies showed increased skin permeation especially in case of dry shaving, electric epilation and waxing. Conclusion: Considering CRS and diffusion cell data, a moderate if significant decrease in skin barrier function was found after hair removal by dry shaving (physical skin/material interaction) and epilation methods (plucking out the entire hair, for example, by electrical epilation and waxing). Subsequent experiments will include testing of different permeants covering a broad range of physicochemical properties in vitro and confirming our findings in vivo.
Skin Pharmacol Physiol 2019;32:8–21

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