Hyaluronic acid gel based on CPM® technology with and without lidocaine: Is there a difference?

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2D1BZ7P

Effects of isotretinoin on the hair cycle

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2PU7oMl

Autologous pure platelet‐rich plasma injections for facial skin rejuvenation: Biometric instrumental evaluations and patient‐reported outcomes to support antiaging effects

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2D2qJYX

The brain-structural correlates of mathematical expertise

Publication date: Available online 22 October 2018

Source: Cortex

Author(s): Tudor Popescu, Elie Sader, Marie Schaer, Adam Thomas, Devin B. Terhune, Ann Dowker, Rogier B. Mars, Roi Cohen Kadosh

Abstract

Studies in several domains of expertise have established that experience-dependent plasticity brings about both functional and anatomical changes. However, little is known about how such changes come to shape the brain in the case of expertise acquired by professional mathematicians. Here, we aimed to identify cognitive and brain-structural (grey and white matter) characteristics of mathematicians as compared to non-mathematicians. Mathematicians and non-mathematician academics from the University of Oxford underwent structural and diffusion MRI scans, and were tested on a cognitive battery assessing working memory, attention, IQ, numerical and social skills. At the behavioural level, mathematical expertise was associated with better performance in domain-general and domain-specific dimensions. At the grey matter level, in a whole-brain analysis, behavioural performance correlated with grey matter density in left superior frontal gyrus – positively for mathematicians but negatively for non-mathematicians; in a region of interest analysis, we found in mathematicians greater grey matter density in the right superior parietal lobule but lower grey matter density in the right intraparietal sulcus and the left inferior frontal gyrus. In terms of white matter, there were no significant group differences in fractional anisotropy or mean diffusivity. These results reveal new insights into the relationship between mathematical expertise and grey matter metrics in brain regions previously implicated in numerical cognition, as well as regions that received less attention in this field so far. Further studies, based on longitudinal designs and cognitive training, could examine the conjecture that such cross-sectional findings arise from a bidirectional link between experience and structural brain changes that is itself subject to change across the lifespan.

https://ift.tt/2PkiBs8

Repeated SBRT for in- and out-of-field recurrences in the liver

Abstract

Purpose

To evaluate the feasibility and toxicity profile of repeated stereotactic body radiotherapy (SBRT) for recurrent primary or secondary liver tumors.

Methods

Consecutive patients with primary (hepatocellular carcinoma [HCC] or cholangiocarcinoma [CCC]) or secondary liver cancer (LM), with intrahepatic recurrence or progression after SBRT, underwent re-SBRT in 3 to 12 fractions with a median time of 15 (range 2–66) months between treatments.

Results

In all, 24 patients which were previously treated with SBRT (30 lesions) were retreated with SBRT for "in- and out-of-field" recurrences (2nd SBRT: n = 28, 3rd SBRT: n = 2). The median follow-up after re-irradiation was 14 months. The median prescribed dose for the first SBRT was 46.5 (range 33–66 Gy, EQD2₁₀ = 70.5) Gy and 48 (range 27–66 Gy, EQD2₁₀ = 71) Gy for the re-SBRT. The median mean liver dose (D_{mean, liver}) was 6 Gy (range 1–25, EQD2₂ = 7 Gy) for the first SBRT and 10 Gy (range 1–63 Gy, EQD2₂ = 9 Gy) for the re-SBRT. Of the 30 re-irradiated lesions 6 were re-irradiated in-field resulting in a median EQD2_{2, maximum} of 359 (range 120–500) Gy for both treatments, with an α/β = 2 to account for liver parenchyma. Treatment was well tolerated. Two patients with stent placement before SBRT developed cholangitis 4 and 14 months after re-SBRT. There were no elevations of the serum liver parameters after re-SBRT. One patient developed a grade 3 gastrointestinal bleeding. There was no radiation induced liver disease (RILD) observed.

Conclusions

Repeated liver SBRT is feasible, without excessive liver toxicity, when there is no considerable overlapping with pre-irradiated portions of the stomach or bowel and enough time for the liver to regenerate.

https://ift.tt/2PjTupx

SBRT planning for spinal metastasis: indications from a large multicentric study

Abstract

Background

The dosimetric variability in spine stereotactic body radiation therapy (SBRT) planning was investigated in a large number of centres to identify crowd knowledge-based solutions.

Methods

Two spinal cases were planned by 48 planners (38 centres). The required prescription dose (PD) was 3 × 10 Gy and the planning target volume (PTV) coverage request was: V_PD > 90% (minimum request: V_PD > 80%). The dose constraints were: planning risk volume (PRV) spinal cord: V_18Gy < 0.35 cm³, V_{21.9 Gy} < 0.03 cm³; oesophagus: V_{17.7 Gy} < 5 cm³, V_{25.2 Gy} < 0.03 cm³. Planners who did not fulfil the protocol requirements were asked to re-optimize the plans, using the results of planners with the same technology. Statistical analysis was performed to assess correlations between dosimetric results and planning parameters. A quality index (QI) was defined for scoring plans.

Results

In all, 12.5% of plans did not meet the protocol requirements. After re-optimization, 98% of plans fulfilled the constraints, showing the positive impact of knowledge sharing. Statistical analysis showed a significant correlation (p < 0.05) between the homogeneity index (HI) and PTV coverage for both cases, while the correlation between HI and spinal cord sparing was significant only for the single dorsal PTV case. Moreover, the multileaf collimator leaf thickness correlated with the spinal cord sparing. Planners using comparable delivery/planning system techniques produced different QI, highlighting the impact of the planner's skills in the optimization process.

Conclusion

Both the technology and the planner's skills are fundamentally important in spine SBRT planning optimization. Knowledge sharing helped to follow the plan objectives.

https://ift.tt/2EG12Pd

Risk of recurrence in patients with papillary thyroid carcinoma and minimal extrathyroidal extension not treated with radioiodine

Abstract

Purpose

This study evaluated the recurrence rate in patients with papillary thyroid carcinoma (PTC) and minimal extrathyroidal extension (mETE) who had low thyroglobulin (Tg) after total thyroidectomy, and therefore, did not receive radioactive iodine (RAI).

Methods

This was a prospective study including 182 patients with tumors ≤ 4 cm and mETE without aggressive histology or clinically apparent lymph node involvement (cN0pNx). After thyroidectomy, all patients had nonstimulated Tg ≤ 0.3 ng/ml, negative antithyroglobulin antibodies (TgAb), and neck ultrasonography (US) showing no anomalies. Because of these results, the patients were not submitted to RAI.

Results

The time of follow-up ranged from 24 to 132 months (median 72 months). One hundred and seventy-eight patients (97.8%) continued to have nonstimulated Tg ≤ 0.3 ng/ml and negative US. Four patients (2.2%) exhibited an increase in Tg and lymph node metastases (structural recurrence). After surgery, these patients obtained nonstimulated Tg < 1 ng/ml and no apparent tumor was detected by the imaging methods.

Conclusion

The results suggest that patients with mETE and without other adverse features, who have low nonstimulated Tg and negative neck US after thyroidectomy, do not require ablation with RAI.

https://ift.tt/2ywUZqI

In Response to “Descriptive Survival Study of Nail Melanoma Patients Treated With Functional Surgery vs Distal Amputation”

Publication date: Available online 23 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Brooke Vasicek, Taylor Erickson, Eden Lake

https://ift.tt/2Sb6Raf

High-Throughput Sequencing of the T-cell receptor beta chain gene distinguishes two subgroups of cutaneous T-cell lymphoma

Publication date: Available online 23 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Jie Wang, Bryan Rea, Paul Haun, Ryan Emerson, Ilan Kirsch, Adam Bagg

https://ift.tt/2yX2V49

Dear Dr. Dermatoethicist: Erection Ethics

Publication date: Available online 23 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Paige Norwick, Gillian K. Weston, Jane M. Grant-Kels

https://ift.tt/2Sb6Gf5

Surgical Pearl: Reverse Beveling to Improve Wound Edge Apposition

Publication date: Available online 23 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Kourosh Beroukhim, Lindsay R. Sklar, Daniel B. Eisen

https://ift.tt/2yXwS43

Association between atopic dermatitis, depression and suicidal ideation: A systematic review and meta-analysis

Publication date: Available online 23 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Kevin R. Patel, Supriya Immaneni, Vivek Singam, Supriya Rastogi, Jonathan I. Silverberg

Abstract

Background

Atopic dermatitis (AD) is associated with psychological distress. However, previous studies found conflicting results about whether AD is associated with increased depression or suicidality.

Objectives

To determine the complex relationship between AD and depression.

Methods

A systematic review was performed of all published observational studies in MEDLINE, Pubmed, EMBASE, GREAT, LILACS, Cochrane Library, Scopus and PsychInfo that analyzed depression in AD. Two reviewers performed study title/abstract review and data abstraction. Pooled meta-analysis was performed using random-effects weighting.

Results

Overall, 106 studies met inclusion criteria; 36 had sufficient data for meta-analysis. The prevalence of any depression was higher in persons with vs. without AD (20.1% vs. 14.8%). Similar results were found in sensitivity analyses of studies assessing clinical depression, depressive symptoms, and adults, with healthy controls, low and high study quality. AD was associated with significantly higher depression scales, parental depression, anti-depressant use, and suicidality. No publication bias was detected

Limitations

Individual level data were not available.

Conclusions

AD patients have higher odds of depression and suicidality.

https://ift.tt/2Sb6uMT

The Cost of an Itch: A Nationally Representative Retrospective Cohort Study of Pruritus-Associated Healthcare Expenditure in the United States

Publication date: Available online 23 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Raghav Tripathi, Konrad D. Knusel, Harib H. Ezaldein, Jeremy S. Bordeaux, Jeffrey F. Scott

https://ift.tt/2yWj9ui

Reply

Publication date: Available online 22 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Suelen Montagner

https://ift.tt/2S9O5Qs

The Prognostic Value of Inositol Polyphosphate 5-Phosphatase in Cutaneous Squamous Cell Carcinoma

Publication date: Available online 22 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Helen JL. Cumksy, Collin M. Costello, Nan Zhang, Richard Butterfield, Matthew Buras, Jessica Schmidt, Kevin Drenner, Steven A. Nelson, Shari A. Ochoa, Christian Baum, Mark R. Pittelkow, David J. DiCaudo, Aleksandar Sekulic, Aaron R. Mangold

Abstract

Background

Inositol Phosphate 5-Phosphatase (INPP5A) has been shown to play a role in development and progression of cutaneous squamous cell carcinoma (cSCC). The goal of the current study is to explore the prognostic value of INPP5A expression in cSCC.

Methods

A total of 189 cases of actinic keratoses and SCCs from 174 patients were identified, clinical and outcome data abstracted, histopathology re-rereviewed, and immunohistochemical (IHC) staining and interpretation was performed for INPP5A.

Results

The majority of tumors (89.4%) had an INPP5A score of 2 or 3. No patients had complete loss of INPP5A. Tumors with INPP5A score of 1 were more likely to be intermediate to high risk (BWH stage T2a and above 85.0% vs 23.7%, p < 0.0001), have a larger diameter (2.4 cm vs. 1.3 cm, p = 0.0004), moderate to poor differentiation (86.7% vs. 17.6%, p < 0.0001), and perineural invasion (37.5% vs. 5.3%, p < 0.0001). INPP5A score of 1 has worse 3-year survival of 42.3% (HR = 2.81, p = 0.0006) and local metastatic rates of 48.0% (HR=4.71, p < 0.0001).

Conclusions

Low INPP5A scores are predictive of aggressive tumors and may be a useful adjunct to guide clinical management of cSCC.

https://ift.tt/2yZIKST

Clinicopathologic, immunophenotypic, and molecular analysis of subcutaneous panniculitis‐like T‐cell lymphoma: A retrospective study in a tertiary care center

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2EFOd7G

Issue Information

Journal of Neuroendocrinology, Volume 30, Issue 11, November 2018.


https://ift.tt/2Sen0Mf

Autophagy and its potent modulators from phytochemicals in cancer treatment

Abstract

Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular components are delivered to the lysosomes for self-digestion and recycling. It is critical in cancer treatment. Therapy-induced autophagy predominantly acts as a pro-survival mechanism, but progressive autophagy can lead to non-apoptotic cell death, also known as autophagic cell death. Plants or herbs contain various natural compounds that are widely used in the treatment of many types of malignancies. Emerging evidence indicates that phytochemicals targeting the autophagic pathway are promising agents for cancer treatment. However, these compounds play different roles in autophagy. In this review, we discussed the role of autophagy in cancer development and therapy, and focussed on elucidating the anti-cancer activities of autophagic modulators, especially phytochemicals. Notably, we described a novel premise that the dynamic role of phytochemicals should be evaluated in regulation of autophagy in cancer.

https://ift.tt/2AnlK2s

Network meta‐analyses of systemic treatments for psoriasis: a critical appraisal

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2An72Zc

Combined THC and CBD to treat pain in epidermolysis bullosa: a report of three cases

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2POE6yp