Correlation between the intensity of Helicobacter pylori colonization and severity of gastritis: Results of a prospective study

alexandrossfakianakis shared this article with you from Inoreader Correlation between the intensity of Helicobacter pylori colonization and severity of gastritis: Results of a prospective study via Helicobacter Abstract Helicobacter pylori infection is strongly associated with chronic gastritis and is probably the main course of chronic inflammation in the gastric mucosa. Gradually, H. pylori gastritis will result in gastric atrophy and intestinal metaplasia. Identifying the relationship between intensity of colonization and activity of gastritis helps the clinician in more effective treatment and post-treatment follow-ups. The aim of our work was to analyze the relationship between the density of H. pylori colonization of the gastric mucosa and the severity of histological parameters of gastritis (inflammation activity, gastric atrophy, and intestinal metaplasia). This was a prospective monocentric study conducted from January 2020 to December 2020, collecting patients naive to any anti-H. pylori treatment and having a chronic H. pylori infection documented by histological examination. Epidemiological, endoscopic, and anathomopathological da ta were collected. Ninety-seven patients with a mean age of 42.6 years [18–65 years] and a sex ratio of M/F = 0.64 were included. The density of H. pylori colonization was mild (+) in 43.3% of patients, moderate (++) in 47.4% of patients, and significant (+++) in 9.3% of patients. Nearly, ten per cent of patients had no gastritis, 33% had mild gastritis, 50.5% had moderate gastritis, and 6.2% had severe gastritis. Gastric atrophy and intestinal metaplasia were found in 44.3% and 10.3% of our population, respectively. Patients with mild H. pylori colonization rates had the highest level of mild activity (59.5%). There was a statistically significant association between the severity of H. pylori infection and gastritis activity (p < .001). Gastric atrophy was significantly associated with the intensity of H. pylori colonization (p = .049). No significant relationship was found between the in tensity of colonization and metaplasia (p = .08). Our study shows that there is a statistically significant association between the density of H. pylori and histopathological findings including gastritis activity and intestinal atrophy. View on Web

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A Nomogram to Predict Nodal Response after Induction Chemotherapy for Hypopharyngeal Carcinoma

alexandrossfakianakis shared this article with you from Inoreader A Nomogram to Predict Nodal Response after Induction Chemotherapy for Hypopharyngeal Carcinoma via The Laryngoscope This study is the first to establish and validate a nomogram based on five critical predictors, including tumor differentiation degree (DD), T classification, metastatic lymph node size (LS), number of lymph node metastases (NOL), and cervical nodal necrosis (CNN), to predict the response of metastatic lymph nodes after induction chemotherapy (ICT) for hypopharyngeal carcinoma patients. Our nomogram yielded relatively good accuracy in predicting the regional ICT response, which will be a useful tool to assist clinicians in future decision-making. Background For hypopharyngeal carcinoma, metastatic neck nodes with a low response to induction chemotherapy (ICT) should not be managed with concomitant chemoradiotherapy (CCRT), and the prediction of chemosensitivity before ICT could prevent adverse events from occurring during chemotherapy. In this study, we developed a nomogram to predict the regional response to ICT. Methods A total of 153 hypopharyngeal carcinoma patients with regional metastasis treated with ICT in our institution from January 2010 to September 2020 were retrospectively studied. According to ICT response evaluated by RECIST 1.1, patients were divided into chemo-insensitive (PR < 70%/SD/PD) (group 1) and chemosensitive (CR/PR ≥ 70%) (group 2) groups. Patients' clinical, image, and hematologic data before ICT were collected. The nomogram was built based on multivariate analysis and stepwise logistic regression and was evaluated from the aspects of discrimination and calibration. Results A nomogram based on five critical predictors, namely, tumor differentiation degree, T classification, metastatic lymph node size, number of lymph node metastases, and cervical nodal necrosis, was developed. The areas under the curve (AUC) values were 0.76 and 0.70 after adjusting the results using bootstrap methods. The calibration curve showed relatively good agreement between the predicted and observed probabilities. Conclusions Our nomogram yielded good accuracy in predicting the regional ICT response and will be a useful tool to assist clinicians in decision making. Level of Evidence 4 Laryngoscope, 2022 View on Web

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FULL ISPNO 2022 ABSTRACTS PDF

alexandrossfakianakis shared this article with you from Inoreader FULL ISPNO 2022 ABSTRACTS PDF via Neuro-Oncology Current Issue View on Web

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Temporomandibular disorders, bite force and osseous changes of the temporomandibular joints in patients with hypermobile Ehlers‐Danlos Syndrome compared to a healthy control group

alexandrossfakianakis shared this article with you from Inoreader Temporomandibular disorders, bite force and osseous changes of the temporomandibular joints in patients with hypermobile Ehlers‐Danlos Syndrome compared to a healthy control group via Journal of Oral Rehabilitation SUMMARY Background Ehlers-Danlos syndrome (EDS) is a hereditary disorder that affects the connective tissue and collagen structures in the body characterized by joint hypermobility, skin hyperextensibility and tissue fragility. Objective The aim was to investigate temporomandibular disorders (TMD), bite force, teeth in occlusal contact and osseous changes of the temporomandibular joints (TMJs) in 26 patients with hypermobile EDS (hEDS), differentiated by a genetic test, compared to 39 healthy controls. METHODS: Clinical examination according to Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), radiological examinations of the TMJs by cone-beam computed tomographic (CBCT) scans, registration of bite force and teeth in occlusal contact was performed. Statistical analyses included Fisher's Exact Test, multiple logistic and linear regression models adjusted for age, gender and Body Mass Index (BMI). Results Single symptoms and signs of TMD occurred significantly more often in hEDS (p=0.002; p=0.001; p=0.003; p=<0.0001; p=0.012) and maximum mouth opening was significantly smaller in hEDS compared to controls (p=<0.0001). The DC/TMD diagnosis myalgia, myofascial pain with referral, arthralgia, headache attributed to TMD, disc displacement disorders and degenerative joint disease occurred significantly more often in hEDS compared to controls (p=0.000; p=0.008; p=0.003; p=0.000; p=<0.0001; p=0.010, respectively). No significant differences were found in bite force and in teeth in occlusal contact between the groups (p>0.05). On CBCT of the TMJs, subcortical sclerosis occurred significantly more often in hEDS compared to controls (p=0.005). Conclusion Symptoms and signs of TMD and osseous changes of the TMJs occurred significantly more often in hEDS. Bite force and teeth in occlusal contact were comparable to controls. View on Web

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Homoarginine Treatment of Rats Improves Cardiac Function and Remodeling in Response to Pressure Overload

alexandrossfakianakis shared this article with you from Inoreader Homoarginine Treatment of Rats Improves Cardiac Function and Remodeling in Response to Pressure Overload via Fundamental & Clinical Pharmacology Abstract Background Low serum concentrations of the amino acid homoarginine (HA) are associated with increased cardiovascular mortality by incompletely understood mechanisms. Objectives This study sought to assess the influence of HA on cardiac remodeling in rats undergoing either transaortic banding or inhibition of nitric oxide synthesis by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME). Methods Male Wistar rats (n=136) underwent a sham operation (SH) or aortic banding (AB). Both groups were equally divided into fourteen subgroups, receiving different doses of HA alone or in combination with lisinopril, spironolactone, or L-NAME over 4 weeks. Results HA treatment in AB animals resulted in a dose-dependent improvement of cardiac function up to a concentration of 800 mg·kg-1·day-1. Combining 800 mg·kg-1·day-1 HA with spironolactone or lisinopril yielded additional effects, showing a positive correlation with LV ejection fraction (+33%, p=0.0002) and fractional shortening (+41%, p=0.0014). An inverse association was observed with collagen area fraction (-41%, p<0.0001), myocyte cross-sectional area (-22%, p<0.0001) and the molecular markers atrial natriuretic factor (-74%, p=0.0091), brain natriuretic peptide (-42%, p=0.0298), beta-myosin heavy chain (-46%, p=0.0411), and collagen type V alpha 1 chain (-73%, p=0.0257) compared to placebo-treated AB animals. Co-administration of HA and L-NAME was found to attenuate cardiac remodeling and prevent NO-deficient hypertension following AB. Conclusion HA treatment has led to a dose-dependent improvement of myocardial function and marked histological and molecular changes in cardiac remodeling following AB. Combining HA with standard heart failure medication resulted in additional beneficial effects boosting its direct impact on heart failure pathophysiology. View on Web

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Nuclear-targeted 4E-BP1 is dephosphorylated, induces nuclear translocation of eIF4E, and alters mRNA translation

alexandrossfakianakis shared this article with you from Inoreader Nuclear-targeted 4E-BP1 is dephosphorylated, induces nuclear translocation of eIF4E, and alters mRNA translation via ScienceDirect Publication: Experimental Cell Research Publication date: Available online 10 June 2022 Source: Experimental Cell Research Author(s): Sho Takahashi, Shusaku Shibutani, Hiroyuki Iwata View on Web

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Rifapentine and isoniazid for prevention of tuberculosis in people with diabetes (PROTID): protocol for a randomised controlled trial

alexandrossfakianakis shared this article with you from Inoreader Rifapentine and isoniazid for prevention of tuberculosis in people with diabetes (PROTID): protocol for a randomised controlled trial via Trials - Latest Articles Diabetes mellitus (DM) increases the risk of tuberculosis (TB) and will hamper global TB control due to the dramatic rise in type 2 DM in TB-endemic settings. In this trial, we will examine the efficacy and sa... View on Web

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Total thyroidectomy versus hemithyroidectomy with intraoperative radiofrequency ablation for unilateral thyroid cancer with contralateral nodules: A propensity score matching study

alexandrossfakianakis shared this article with you from Inoreader Total thyroidectomy versus hemithyroidectomy with intraoperative radiofrequency ablation for unilateral thyroid cancer with contralateral nodules: A propensity score matching study via Most Recent Articles: Journal of Otolaryngology - Head & Neck Surgery For unilateral papillary thyroid carcinoma (PTC) patients with contralateral benign nodules, optimal treatment decisions are made according to patient preference and the disease's pathological features. This s... View on Web

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Isolated cerebral toxoplasmosis 17 years post renal transplant

alexandrossfakianakis shared this article with you from Inoreader Isolated cerebral toxoplasmosis 17 years post renal transplant via Transplant Infectious Disease View on Web

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A novel nonsense PKD1L1 variant cause heterotaxy syndrome with congenital asplenia in a Han Chinese patient

alexandrossfakianakis shared this article with you from Inoreader A novel nonsense <i>PKD1L1</i> variant cause heterotaxy syndrome with congenital asplenia in a Han Chinese patient via Journal of Human Genetics - Issue - nature.com science feeds Journal of Human Genetics, Published online: 13 June 2022; doi:10.1038/s10038-022-01053-w A novel nonsense PKD1L1 variant cause heterotaxy syndrome with congenital asplenia in a Han Chinese patient View on Web

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Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy

alexandrossfakianakis shared this article with you from Inoreader Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy via Journal of Human Genetics - Issue - nature.com science feeds Journal of Human Genetics, Published online: 13 June 2022; doi:10.1038/s10038-022-01055-8 Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy View on Web

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