On the origin of the European Acheulian

Publication date: December 2016
Source:Journal of Anthropological Archaeology, Volume 44, Part A
Author(s): Kenneth Martínez, Joan Garcia Garriga
The Mode 1 to Mode 2 transition in Europe has become a key research debate on early hominins. In this paper, the available data are used to propose a new interpretation of the origin of the Acheulian by analysing the transition through the lithic industry at key circum-Mediterranean sites with Early-Middle Pleistocene chronology: Vallparadís, Gran Dolina TD6, Barranc de la Boella, and Caune de l'Arago 'P' levels. Regarding these lithic records, we propose here the hypothesis based on an evolution of new technological behaviours in Europe before 0.5Myr carried out from autochthonous populations with Mode 1 industries, combined with external adaptive and technological influences. We interpret the chronology and lithic assemblages of these sites within the transition process towards Acheulian, in which structural continuity of Mode 1 is complemented with the gradual appearance of some foreign innovations (bifacial technology). This technological transition is envisaged as a historical process: the outcome of the cultural evolution resulted from contacts and exchanges between hominin groups from western Eurasia with different social and technological adaptations, in contact and competition with each other. This historical process would explain the time lag between Africa, Levant, and Europe in the spread of the Acheulian, as well as a technological evolution of the European Mode 1 and the gradual expansion of the Acheulian across Europe.



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Health-related quality of life assessment in contemporary phase iii trials in advanced colorectal cancer

Publication date: Available online 30 September 2016
Source:Cancer Treatment Reviews
Author(s): Krzysztof Adamowicz, Everardo D. Saad, Jacek Jassem
BackgroundHealth-related quality of life (HRQOL) is often used as an endpoint in cancer clinical trials. We assessed the frequency and correlates of HRQOL use in phase III trials in advanced colorectal cancer.MethodsWe searched PubMed for phase III trials published between January 1998 and December 2014, as well as for companion papers reporting on HRQOL separately. We excluded papers reporting on correlative biology or prognostic factors in isolation from the main trial results, as well as trials on supportive care and on local therapy.ResultsWe retrieved 111 trials that enrolled a total of 61,531 patients in 241 trial arms. HRQOL was reportedly used as an endpoint in 40 trials (36%), in all but two as a secondary endpoint. There was a significant decrease in the use of HRQOL, with frequencies of 46% in trials published between 1998 and 2006, and 27% between 2007 and 2014 (P=0.04). Trials with HRQOL as endpoint were significantly larger than trials without such endpoint. Formal statistical comparisons involving HRQOL parameters were reported in 36 of 40 trials (90%) with HRQOL assessment, with a significant difference between arms found in 14 (39%), six of which favoring the experimental arm. HRQOL gains were usually accompanied by improvements in efficacy endpoints, but were not related to the number of patients or chemotherapy line.ConclusionsHRQOL has been formally assessed in about one-third of recent phase III trials in advanced colorectal cancer, with a significant gain in HRQOL in about 40% of cases. It is questionable whether HRQOL results may largely help select between competing treatments. This assumption may be one of the reasons for the apparent decreased use of HRQOL as an endpoint in phase III trials in this disease.



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Defibrotide for the management of sinusoidal obstruction syndrome in patients who undergo haemopoietic stem cell transplantation

Publication date: Available online 30 September 2016
Source:Cancer Treatment Reviews
Author(s): John Coutsouvelis, Sharon Avery, Michael Dooley, Carl Kirkpatrick, Andrew Spencer
Sinusoidal obstruction syndrome, previously known as veno-occlusive disease (VOD/SOS), is a complication in patients undergoing haemopoietic stem cell transplantation (HSCT). Severe VOD/SOS, including progression to multi-organ failure, has resulted in a mortality of greater than 80%. Defibrotide's varying pharmacological actions, particularly on endothelial cells, make it is a useful agent to consider for prophylaxis and treatment of VOD/SOS. Barriers to its routine use include the high acquisition cost and the fact that neither the oral or parenteral formulations are licensed products in many countries at this time. This review summarises available literature on the use of defibrotide in the management of VOD/SOS. Publications consist predominantly of single centre cohort studies and case series. Available evidence indicates that defibrotide is effective in the management of VOD/SOS. Using defibrotide prophylaxis should also be considered, especially in the paediatric setting, where there are available results from a large, open label, randomized controlled trial. Patient outcome data from the larger studies and compassionate programs can inform consensus recommendations on dosing regimen and criteria for the treatment of VOD/SOS with defibrotide in the adult population. The reviewed literature indicates an effective and safe dose for treatment is 25mg/kg/day, continued for at least 14 days or until complete response is achieved. Further studies are required to determine the optimal dose and duration of treatment in both paediatric patients and adults. Recent recommendations and a phase 3 trial using historical controls indicate that defibrotide should be included as a pharmacotherapy option in protocols guiding management of VOD/SOS.



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Comparison of Canadian and Swiss Surgical Training Curricula: Moving on Toward Competency-Based Surgical Education

Publication date: Available online 30 September 2016
Source:Journal of Surgical Education
Author(s): Henry Hoffmann, Daniel Oertli, Robert Mechera, Salome Dell-Kuster, Rachel Rosenthal, Richard Reznick, Hugh MacDonald
ObjectiveQuality of surgical training in the era of resident duty-hour restrictions (RDHR) is part of an ongoing debate. Most training elements are provided during surgical service. As exposure to surgical procedures is important but time-consuming, RDHR may affect quality of surgical training. Providing structured training elements may help to compensate for this shortcoming.DesignThis binational anonymous questionnaire-based study evaluates frequency, time, and structure of surgical training programs at 2 typical academic teaching hospitals with different RDHR.SettingDepartments of Surgery of University of Basel (Basel, Switzerland) and the Queen's University (Kingston, Ontario, Canada).ParticipantsSurgical consultants and residents of the Queen's University Hospital (Kingston, Ontario, Canada) and the University Hospital Basel (Basel, Switzerland) were eligible for this study.ResultsQuestionnaire response rate was 37% (105/284). Queen's residents work 80 hours per week, receiving 7 hours of formal training (8.8% of workweek). Basel residents work 60 hours per week, including 1 hour of formal training (1.7% of working time). Queen's faculty and residents rated their program as "structured" or "rather structured" in contrast to Basel faculty and residents who rated their programs as "neutral" in structure or "unstructured." Respondents identified specific structured training elements more frequently at Queen's than in Basel. Two-thirds of residents responded that they seek out additional surgical experiences through voluntary extra work. Basel participants articulated a stronger need for improvement of current surgical training. Although Basel residents and consultants in both institutions fear negative influence of RDHR on the training program, this was not the case in Queen's residents.ConclusionsProviding more structured surgical training elements may be advantageous in providing optimal-quality surgical education in an era of work-hour restrictions.



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NMR in drug discovery: A practical guide to identification and validation of ligands interacting with biological macromolecules

Publication date: Available online 30 September 2016
Source:Progress in Nuclear Magnetic Resonance Spectroscopy
Author(s): Alvar Gossert, Wolfgang Jahnke
Protein-ligand interactions are at the heart of drug discovery research. NMR spectroscopy is an excellent technology to identify and validate protein-ligand interactions. A plethora of NMR methods are available which are powerful, robust and information rich, but also have pitfalls and limitations. In this review, we will focus on how to choose between different experiments, and assess their strengths and liabilities. We introduce the concept of the validation cross, which helps to categorize experiments according to their information content and to simplify the choice of the right experiment in order to address a specific question. Additionally, we will provide the framework for drawing correct conclusions from experimental results in order to accurately evaluate such interactions. Out of scope for this review are methods for subsequent characterization of the interaction such as quantitative KD determination, binding mode analysis, or structure determination.

Graphical abstract

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Keyword index

Publication date: August 2016
Source:Best Practice & Research Clinical Endocrinology & Metabolism, Volume 30, Issue 4





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Chemokine receptor CXCR2 in dorsal root ganglion contributes to the maintenance of inflammatory pain

Publication date: Available online 30 September 2016
Source:Brain Research Bulletin
Author(s): De-Li Cao, Bin Qian, Zhi-Jun Zhang, Yong-Jing Gao, Xiao-Bo Wu
Chemokines and their receptors have been demonstrated to be important contributors to the development and maintenance of chronic pain. Recent studies showed that chemokine (C-X-C motif) ligand 1 (CXCL1) and its major receptor CXCR2 are respectively expressed in astrocytes and neurons in the spinal cord and are involved in the maintenance of neuropathic pain and inflammatory pain via astrocytic-neuronal interaction. Here we investigated how CXCL1 and CXCR2 are regulated in the dorsal root ganglion (DRG) after peripheral injection of complete Freund's adjuvant (CFA) and its implication in inflammatory pain. CFA induced rapid increase of CXCL1 mRNA and protein in the DRG. Double immunostaining showed that CXCL1 was colocalized with calcitonin gene-related peptide (CGRP), isolectin B4 (IB4), and neurofilament 200 (NF200). Furthermore, CXCR2 mRNA was increased 3h after CFA injection and maintained for more than 3 days. CXCR2 protein was also increased and colocalized with CGRP, IB4, and NF200. Finally, perisciatic nerve injection of CXCR2 siRNA to specifically knock down CXCR2 in the DRG effectively attenuated CFA-induced mechanical allodynia and heat hyperalgesia, and the effect maintained for more than 5 days. Taken together, our results demonstrated that CXCL1 and CXCR2 may regulate the maintenance of inflammatory pain via an autocrine/paracrine way in DRG neurons.



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Establishing and Prioritising Research Questions for the Treatment of Alopecia Areata: The Alopecia Areata Priority Setting Partnership

Summary

Background

Alopecia areata is a common hair loss disorder that results in patchy to complete hair loss. Many uncertainties exist around the most effective treatments for this condition.

Objectives

To identify uncertainties in alopecia areata management and treatment that are important to both service users (people with hair loss, carers and relatives) and healthcare professionals.

Methods

An alopecia areata priority setting partnership was established between patients, their carers and relatives, and healthcare professionals to identify the most important uncertainties in alopecia areata. The methodology of the James Lind Alliance was followed to ensure a balanced, inclusive and transparent process.

Results

In total 2747 treatment uncertainties were submitted by 912 participants, of which 1012 uncertainties relating to alopecia areata (and variants) were analyzed. Questions were combined into "indicative uncertainties" following a structured format. A series of ranking exercises further reduced this list to a top 25 that were taken to a final prioritization workshop where the top 10 priorities were agreed.

Conclusions

We present the top 10 research priorities for alopecia areata to guide researchers and funding bodies to support studies important to both patients and clinicians.

This article is protected by copyright. All rights reserved.

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Increased protoporphyrin IX accumulation does not improve the effect of photodynamic therapy for actinic keratosis: a randomized controlled trial

Summary

Background

Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) is highly effective for treating actinic keratosis (AKs) on the face/scalp, but less effective on the extremities. Insufficient accumulation of protoporphyrin IX (PpIX) may cause these inferior efficacy rates. However, it is possible to increase PpIX accumulation by extending MAL application time and/or pretreating the skin with curettage.

Objectives

To investigate whether increased PpIX accumulation improves the effect of MAL-PDT for AKs in a randomized intraindividual study.

Methods

Twenty-two patients with 533 AKs on both hands were treated with MAL-PDT. To obtain different concentrations of PpIX, 4 symmetrical areas on each patient were randomly allocated to different regimens: (i) 3h MAL application without prior curettage (3hC-), (ii) 3h with curettage (3hC+), (iii) 21h without curettage (21hC-) and (iv) 21h with curettage (21hC+). Treatment efficacy was evaluated after 3 months, whereas PpIX fluorescence, pain and erythema were assessed during and after PDT.

Results

Extended MAL application with and without curettage increased PpIX accumulation significantly compared with the standard 3hC+ regimen (P=0.0001 and P=0.002, respectively). However, the median total clearance rates did not improve accordingly: 3hC+ (55.0%), 21hC- (55.0%) and 21hC+ (53.6%). Conversely, insufficient PpIX accumulation in the 3hC- regimen led to a significantly lower clearance rate (33.3%) than the other regimens (P<0.045). Furthermore, pain and erythema were correlated to PpIX accumulation.

Conclusions

Increased PpIX accumulation does not improve the effect of MAL-PDT for AKs on the hands, but leads to worse adverse events. Different strategies are needed to improve PDT on the extremities.

This article is protected by copyright. All rights reserved.

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The rs2274911 polymorphism in GPRC6A gene is associated with insulin resistance in normal weight and obese subjects

Abstract

Objective

Identification of the novel endocrine role of osteocalcin (OC) and its receptor GPRC6A has given rise to a new branch of research in OC/GPRC6A axis related to glucose metabolism. GPRC6A- and OC-deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism rs2274911 in GPRC6A was shown to be associated with testicular impairment. We aimed to investigate the role of rs2274911 polymorphism in glucose and lipid metabolism in a cohort of normal weight and obese subjects

Design, Patients, Settings

A total of 392 male and females, including 218 obese patients and 174 age-matched normal weight controls were retrospectively selected.

Results

The distribution of rs2274911 alleles and genotypes did not differ either between normal weight and obese subjects or sexes (all p >0.05). Age- and OC-adjusted multivariate analysis revealed that, in the normal weight group, fasting insulin and HOMA-IR increased in GA (p =0.016 and p =0.025) and AA genotypes (p =0.033 and p =0.040) compared with GG homozygotes. In the obese group, AA homozygotes had increased fasting glucose (p =0.041 vs GG). Triglycerides, fasting insulin and HOMA-IR increased in both GA (p =0.020, p <0.001 and p =0.001) and AA genotype (p =0.021, p =0.013 and p =0.013).

Conclusion

In a cohort of normal weight and obese subjects, we found that the non-rare polymorphism rs2274911 in the GPRC6A gene was associated with insulin resistance features, independently of the metabolic phenotype and OC levels.

This article is protected by copyright. All rights reserved.

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Scholar : These new articles for Body, Movement and Dance in Psychotherapy are available online

The online platform for Taylor & Francis Online content New for Body, Movement and Dance in Psychotherapy and online now on Taylor & Francis Online: Comments Body and movement in dynamic psychotherapy: reflections on talking and movement therapies E. Shuper Engelhard Pages: 1-13 | DOI: 10.1080/17432979.2016.1239590 Routledge Journals Gerontology Portfolio - find out more here: http://ift.tt/2crU79K This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Behavioral Sciences of Terrorism and Political Aggression are available online

The online platform for Taylor & Francis Online content New for Behavioral Sciences of Terrorism and Political Aggression and online now on Taylor & Francis Online: Original Articles 'It's not paranoia when they are really out to get you': the role of conspiracy theories in the context of heightened security | Benjamin J. Lee Pages: 1-17 | DOI: 10.1080/19434472.2016.1236143 Read our collection of free articles created as a companion to the BPS PsychCrunch podcast. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Arts & Health are available online

The online platform for Taylor & Francis Online content New for Arts & Health and online now on Taylor & Francis Online: Research Reliability and validity of the Meaningfulness of Songwriting Scale with university students taking a popular songwriting class Felicity Anne Baker, Raymond Afredo Rossi MacDonald & Mark Clement Pollard Pages: 1-12 | DOI: 10.1080/17533015.2016.1236281 Journal of HIV/AIDS & Social Services – FREE ACCESS Article Collection - click here This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Chronic hyperglycemia affects bone metabolism in adult zebrafish scale model

Abstract

Type II diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia that induce other pathologies including diabetic retinopathy and bone disease. The mechanisms implicated in bone alterations induced by type II diabetes mellitus have been debated for years and are not yet clear because there are other factors involved that hide bone mineral density alterations. Despite this, it is well known that chronic hyperglycemia affects bone health causing fragility, mechanical strength reduction and increased propensity of fractures because of impaired bone matrix microstructure and aberrant bone cells function. Adult Danio rerio (zebrafish) represents a powerful model to study glucose and bone metabolism. Then, the aim of this study was to evaluate bone effects of chronic hyperglycemia in a new type II diabetes mellitus zebrafish model created by glucose administration in the water. Fish blood glucose levels have been monitored in time course experiments and basal glycemia was found increased. After 1 month treatment, the morphology of the retinal blood vessels showed abnormalities resembling to the human diabetic retinopathy. The adult bone metabolism has been evaluated in fish using the scales as read-out system. The scales of glucose-treated fish didn't depose new mineralized matrix and shown bone resorption lacunae associated with an intense osteoclast activity. In addition, hyperglycemic fish scales have shown a significant decrease of alkaline phosphatase activity and increase of tartrate-resistant acid phosphatase activity, in association with alterations in other bone-specific markers. These data indicates an imbalance in bone metabolism, which leads to the osteoporotic-like phenotype visualized through scale mineral matrix staining. The zebrafish model of hyperglycemic damage can contribute to elucidate in vivo the molecular mechanisms of metabolic changes, which influence the bone tissues regulation in human diabetic patients.

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Vitamin D and gallstone disease—A population-based study

Abstract

Gallstone disease is highly prevalent in the general population and is a major gastrointestinal cause of hospital admissions. The objectives were to determine whether circulating levels of 25-hydroxyvitamin D were associated to ultrasound proven gallstones or cholecystectomy in a general population sample. Determinants of vitamin D status were also explored. A random sample of 4130 people from the population of Copenhagen with ages 41–71 years were invited (N = 4130) and 2650 participants were included. Ultrasound examinations were performed to assess gallstone status and blood samples were drawn to assess 25-hydroxyvitamin D and biomarkers of renal and hepatic function. Gallstone disease was found in 422 participants. Associations were estimated by logistic regression models. Levels of 25-hydroxyvitamin D was not significantly associated with gallstone disease. Time of birth during low vitamin D exposure was associated with gallstone disease (gallstone prevalence 18.0 versus 14.4 %, odds ratio 1.33, 95 % confidence interval [1.07; 1.65]). Highest quartile of cystatin C was significantly associated with gallstone disease (gallstone prevalence 22.1 versus 12.0 %, odds ratio 1.53, 95 % confidence interval [1.08; 2.18]). Serum levels of creatinine and alanine amino transferase were not associated with gallstone disease. Sensitivity analyses excluding participants with cholecystectomy did not alter results significantly. No association between 25-hydroxyvitamin D and gallstone disease was identified. Findings suggest gallstones to be associated to low vitamin D exposure in utero and to renal failure suggesting that vitamin D might have an impact on gallstone disease. Future studies should explore associations for vitamin D and gallstone disease prospectively.

http://ift.tt/2cIU5de

Scholar : These new articles for Aging, Neuropsychology, and Cognition are available online

The online platform for Taylor & Francis Online content New for Aging, Neuropsychology, and Cognition and online now on Taylor & Francis Online: Original Articles Time-of-day affects prospective memory differently in younger and older adults Nicolas Rothen & Beat Meier Pages: 1-13 | DOI: 10.1080/13825585.2016.1238444 The Opiate Epidemic Click here for the Free Access Article Collection. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Suppressive effect of β,β-dimethylacryloyl alkannin on activated dendritic cells in psoriasis by the TLR7/8 pathway

Publication date: November 2016
Source:International Immunopharmacology, Volume 40
Author(s): Yan Wang, Jingxia Zhao, Tingting Di, Mingxing Wang, Zhitong Ruan, Lu Zhang, Xiangjiang Xie, Yujiao Meng, Yan Lin, Xin Liu, Ning Wang, Ping Li
β,β-dimethylacryloyl alkannin (DMA) is a key component of Lithospermum and possesses good efficacy for treating psoriasis. DMA inhibits activated dendritic cells (DCs), but the mechanism is unknown. Therefore, this study aimed to explore the modulation of the TLR7/8 pathway by DMA in psoriasis-activated DCs. Models of psoriasis-like skin lesions were established using BALB/c mice; 8 mice were treated with DMA (2.5mg/kg). Bone marrow cells were isolated and induced into DCs using R848, a TLR7/8 agonist. Splenic CD11c+ cells were detected by flow cytometry. Skin CD11c+ cells were detected by immunofluorescence. TLR7, TLR8, MYD88, and IRAKM proteins were detected by Western blot. The effects of DMA on surface molecules of DCs were observed by flow cytometry. mRNA expression of inflammatory factors was detected by qRT-PCR. Secreted cytokines were detected by cytometric bead array. Compared with the model group, psoriasis-like skin lesions were alleviated by DMA, the splenic CD11c+ cells were significantly decreased (P<0.01), and CD11c+ cell numbers in skin lesions were decreased (P<0.01). Expression levels of TLR7, MYD88, and IRAKM were significantly decreased (P<0.05). R848-stimulated DCs showed increased expression of I-A/I-E, CD80, and CD86 (P<0.01), increased IL-23 and IL-1β mRNA and secretion (P<0.05), and increased TLR7, TLR8, MYD88, and IRAKM expression (P<0.01); DMA inhibited all of these effects of the TLR7/8 pathway activation by R848 (P<0.05). In conclusion, DMA could inhibit psoriasis-activated DCs via the TLR7/8 pathway.



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Response to ‘Re: Endovascular Therapy for Large Vessel Vasculopathy in HIV-Infected Patients'

Publication date: Available online 30 September 2016
Source:European Journal of Vascular and Endovascular Surgery
Author(s): B. Pillay, P.K. Ramdial, D.P. Naidoo




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Scholar : These new articles for Applied Developmental Science are available online

The online platform for Taylor & Francis Online content New for Applied Developmental Science and online now on Taylor & Francis Online: Original Articles Evaluation of a leadership program for First Nations, Métis, and Inuit Youth: Stories of positive youth development and community engagement Tanya Halsall & Tanya Forneris Pages: 1-14 | DOI: 10.1080/10888691.2016.1231579 The Opiate Epidemic Click here for the Free Access Article Collection. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Annals of the American Association of Geographers, Volume 106, Issue 6, November 2016 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Annals of the American Association of Geographers, Volume 106, Issue 6, November 2016 is now available online on Taylor & Francis Online. This new issue contains the following articles: Environmental Science Pace of Landscape Change and Pediment Development in the Northeastern Sonoran Desert, United States Phillip H. Larson, Scott B. Kelley, Ronald I. Dorn & Yeong Bae Seong Pages: 1195-1216 | DOI: 10.1080/24694452.2016.1201420 Environmental Sciences A Shape Metric Methodology for Studying the Evolving Geometries of Synoptic-Scale Precipitation Patterns in Tropical Cyclones Stephanie E. Zick & Corene J. Matyas Pages: 1217-1235 | DOI: 10.1080/24694452.2016.1206460 Methods, Models, and GIS Urban–Rural Differences in Disaster Resilience Susan L. Cutter, Kevin D. Ash & Christopher T. Emrich Pages: 1236-1252 | DOI: 10.1080/24694452.2016.1194740 Error Analysis of Regional Migration Modeling Jianfa Shen Pages: 1253-1267 | DOI: 10.1080/24694452.2016.1197767 Application of a Global Environmental Equity Index in Montreal: Diagnostic and Further Implications Mathieu Carrier, Philippe Apparicio, Yan Kestens, Anne-Marie Séguin, Hien Pham, Dan Crouse & Jack Siemiatycki Pages: 1268-1285 | DOI: 10.1080/24694452.2016.1197766 Is Poverty Decentralizing? Quantifying Uncertainty in the Decentralization of Urban Poverty | Leo Kavanagh, Duncan Lee & Gwilym Pryce Pages: 1286-1298 | DOI: 10.1080/24694452.2016.1213156 Cellular Automata Modeling of Land-Use/Land-Cover Dynamics: Questioning the Reliability of Data Sources and Classification Methods Yulia Grinblat, Michael Gilichinsky & Itzhak Benenson Pages: 1299-1320 | DOI: 10.1080/24694452.2016.1213154 Using Urban Development Boundaries to Constrain Uncontrolled Urban Sprawl in China Penghui Jiang, Qianwen Cheng, Yuan Gong, Liyan Wang, Yunqian Zhang, Liang Cheng, Manchun Li, Jiancheng Lu, Yuewei Duan, Qiuhao Huang & Dong Chen Pages: 1321-1343 | DOI: 10.1080/24694452.2016.1198213 Nature and Society Fluid Sovereignty: State–Nature Relations in the Hasbani Basin, Southern Lebanon Michael Mason & Mohamad Khawlie Pages: 1344-1359 | DOI: 10.1080/24694452.2016.1213155 People, Place, and Region Toward a Geography of Black Internationalism: Bayard Rustin, Nonviolence, and the Promise of Africa | Jake Hodder Pages: 1360-1377 | DOI: 10.1080/24694452.2016.1203284 Cradle of the Creative Class: Reinventing the Figure of the Scientist in Cold War Pittsburgh Patrick Vitale Pages: 1378-1396 | DOI: 10.1080/24694452.2016.1199317 Shards and Stages: Migrant Lives, Power, and Space Viewed from Doha, Qatar Robina Mohammad & James D. Sidaway Pages: 1397-1417 | DOI: 10.1080/24694452.2016.1209402 Presidential Address Embracing Complexity and Uncertainty Julie A. Winkler Pages: 1418-1433 | DOI: 10.1080/24694452.2016.1207973 Corrigendum Corrigendum Shiran Zhong & Ling Bian Pages: 1434-1434 | DOI: 10.1080/24694452.2016.1214430 Miscellaneous Manuscript Reviewers Pages: 1435-1436 | DOI: 10.1080/24694452.2016.1232122 Annals, Volume 106 Index Pages: 1437-1443 | DOI: 10.1080/24694452.2016.1232123 Political Communication Free Access Virtual Special Issue: US Elections & Campaigns This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.