Unusual presentation of primary cutaneous follicle centre B-Cell Lymphoma (PC-FCL) of the nose

Primary Cutaneous Follicle Center B-cell Lymphoma (PC-FCL) is an indolent lymphoma with progressive growth and rare dissemination to extracutaneous sites and usually affects the skin of the scalp, forehead, and trunk. PC-FCL clinically mimicking other dermatologic diseases are extremely rare but could hinder a correct diagnosis. In this experimental work we describe two unusual cases of follicle centre B-Cell Lymphoma (PC-FCL) of the nose. The divulgation of such cases could assist clinicians in the differential diagnosis of nodular lesions of the nose.

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EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.

Publication date: Available online 10 July 2017
Source:DNA Repair
Author(s): Chun-Chin Chen, Elena Avdievich, Yongwei Zhang, Yu Zhang, Kaichun Wei, Kyeryoung Lee, Winfried Edelmann, Maria Jasin, Jeannine R. LaRocque
DNA double-strand breaks (DSBs) can be repaired through several mechanisms, including homologous recombination (HR). While HR between identical sequences is robust in mammalian cells, HR between diverged sequences is suppressed by DNA mismatch-repair (MMR) components such as MSH2. Exonuclease I (EXO1) interacts with the MMR machinery and has been proposed to act downstream of the mismatch recognition proteins in mismatch correction. EXO1 has also been shown to participate in extensive DSB end resection, an initial step in the HR pathway. To assess the contribution of EXO1 to HR in mammalian cells, DSB-inducible reporters were introduced into Exo1^−/− mouse embryonic stem cells, including a novel GFP reporter containing several silent polymorphisms to monitor HR between diverged sequences. Compared to HR between identical sequences which was not clearly affected, HR between diverged sequences was substantially increased in Exo1^−/− cells although to a lesser extent than seen in Msh2^−/− cells. Thus, like canonical MMR proteins, EXO1 can restrain aberrant HR events between diverged sequence elements in the genome.



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An Unintended Consequence of the 21st-Century Cures Act for Patients With Heart Failure.

Author: Gilstrap, Lauren G. MD; MPH; DeFilippis, Ersilia M. MD; Stevenson, Lynne W. MD

Page: 123-125

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Prevalence of Subclinical Coronary Artery Disease in Masters Endurance Athletes With a Low Atherosclerotic Risk Profile.

Author: Merghani, Ahmed MD; Maestrini, Viviana PhD; Rosmini, Stefania MD; Cox, Andrew T. MD; Dhutia, Harshil MD; Bastiaenan, Rachel PhD; David, Sarojini MD; Yeo, Tee Joo MD; Narain, Rajay MD; Malhotra, Aneil MD; Papadakis, Michael MD; Wilson, Mathew G. PhD; Tome, Maite MD; AlFakih, Khaled MD; Moon, James C. MD; Sharma, Sanjay MD

Page: 126-137

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Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in Athletes.

Author: Aengevaeren, Vincent L. MD; Mosterd, Arend MD, PhD; Braber, Thijs L. MD; Prakken, Niek H.J. MD, PhD; Doevendans, Pieter A. MD, PhD; Grobbee, Diederick E. MD, PhD; Thompson, Paul D. MD; Eijsvogels, Thijs M.H. PhD *; Velthuis, Birgitta K. MD, PhD *

Page: 138-148

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Coronary Artery Calcification Among Endurance Athletes: "Hearts of Stone".

Author: Baggish, Aaron L. MD; Levine, Benjamin D. MD

Page: 149-151

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Black-White Differences in Incident Fatal, Nonfatal, and Total Coronary Heart Disease.

Author: Colantonio, Lisandro D. MD, MSc, PhD; Gamboa, Christopher M. MPH; Richman, Joshua S. MD, PhD; Levitan, Emily B. ScD; Soliman, Elsayed Z. MD, MSc, MS; Howard, George DrPH; Safford, Monika M. MD

Page: 152-166

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Thirty-Day Readmissions After Endovascular or Surgical Therapy for Critical Limb Ischemia: Analysis of the 2013 to 2014 Nationwide Readmissions Databases.

Author: Kolte, Dhaval MD, PhD; Kennedy, Kevin F. MS; Shishehbor, Mehdi H. DO, MPH; Abbott, J. Dawn MD; Khera, Sahil MD, MPH; Soukas, Peter MD; Mamdani, Shafiq T. MD; Hyder, Omar N. MD; Drachman, Douglas E. MD; Aronow, Herbert D. MD, MPH

Page: 167-176

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Thirty-Day Readmissions for Critical Limb Ischemia: Ready for a New Quality Metric?.

Author: Looser, Patrick M. MD; Feldman, Dmitriy N. MD

Page: 177-179

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Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of [beta]-Catenin Signaling.

Author: Bucher, Felicitas MD *; Zhang, Ding PhD *; Aguilar, Edith MD; Sakimoto, Susumu MD, PhD; Diaz-Aguilar, Sophia; Rosenfeld, Mauricio BS; Zha, Zhao PhD; Zhang, Hongkai PhD; Friedlander, Martin MD, PhD; Yea, Kyungmoo PhD

Page: 180-195

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Eye-Opening Potential for Tetraspanin Tspan12 as a Therapeutic Target for Diseases of the Retinal Vasculature.

Author: Tomlinson, Michael G. DPhil

Page: 196-199

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Exosomal MicroRNA Transfer Into Macrophages Mediates Cellular Postconditioning.

Author: de Couto, Geoffrey PhD *; Gallet, Romain MD *; Cambier, Linda PhD; Jaghatspanyan, Ervin BA; Makkar, Nupur BSc; Dawkins, James Frederick DVM; Berman, Benjamin P. PhD; Marban, Eduardo MD, PhD

Page: 200-214

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Personalizing Risk Stratification for Sudden Death in Dilated Cardiomyopathy: The Past, Present, and Future.

Author: Halliday, Brian P. MBChB; Cleland, John G.F. MD, PhD; Goldberger, Jeffrey J. MD; Prasad, Sanjay K. MD

Page: 215-231

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Emerging Data Show E-Cigarettes May Pose Heart Risk.

Author: Kuehn, Bridget M.

Page: 232-233

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Looking for the Right Side in Large Vessel Vasculitis: A Multimodality Imaging-Guided Success.

Author: Ramalho, Ana Rita MD; Costa, Susana MD; Silva Marques, Joao MD

Page: 234-238

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Letter by Zimmermann et al Regarding Article, "Excess Cardiovascular Risk in Women Relative to Men Referred for Coronary Angiography Is Associated With Severely Impaired Coronary Flow Reserve, Not Obstructive Disease".

Author: Zimmermann, Frederik M. MD; Zelis, Jo M. MD; van't Veer, Marcel PhD

Page: 239-240

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Response by Taqueti and Di Carli to Letter Regarding Article, "Excess Cardiovascular Risk in Women Relative to Men Referred for Coronary Angiography Is Associated With Severely Impaired Coronary Flow Reserve, Not Obstructive Disease".

Author: Taqueti, Viviany R. MD, MPH; Di Carli, Marcelo F. MD

Page: 241-242

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Letter by Stergiopoulos et al Regarding Article, "Burden of Arrhythmia in Pregnancy".

Author: Stergiopoulos, Kathleen MD, PhD; Lima, Fabio V. MD, MPH; Yang, Jie PhD

Page: 243

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Response by Vaidya et al to Letter Regarding Article, "Burden of Arrhythmia in Pregnancy".

Author: Vaidya, Vaibhav R. MBBS; Arora, Shilpkumar MD; Patel, Nileshkumar MD; Badheka, Apurva MD; Patel, Nilay MD; Agnihotri, Kanishk MD; Billimoria, Zeenia MD; Turakhia, Mintu P. MD, MAS; Friedman, Paul A. MD; Madhavan, Malini MBBS; Kapa, Suraj MD; Noseworthy, Peter A. MD; Cha, Yong-Mei MD; Gersh, Bernard MBChB, DPhil; Asirvatham, Samuel J. MD; Deshmukh, Abhishek J. MBBS

Page: 244-245

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Seasonal variations in the NO2 artifact from chemiluminescence measurements with a molybdenum converter at a suburban site in Korea (downwind of the Asian continental outflow) during 2015–2016

Publication date: September 2017
Source:Atmospheric Environment, Volume 165
Author(s): Jinsang Jung, JaeYong Lee, ByungMoon Kim, SangHyub Oh
This paper investigates the NO2 artifact associated with the chemiluminescence measurement technique that uses a molybdenum converter by applying the same technique but with a photolytic converter at a site downwind of the Asian continental outflow (Daejeon, Korea). The NO2 to NO conversion efficiencies of the molybdenum and photolytic converters were found to be 100% and 95%, respectively, at an ambient level of NO2 (<100 ppbv). Two NO2 monitors equipped with molybdenum and photolytic converters were deployed for ambient NO2 measurements in Daejeon, Korea between the fall of 2015 and the summer of 2016. It was found that the monitor equipped with the molybdenum converter overestimated NO2 levels by 20.4 ± 14.7% when compared with the actual NO2 level in the Daejeon atmosphere over the entire measurement period. This NO2 artifact (ΔNO2), defined as the difference between molybdenum NO2 and photolytic NO2 values, correlated well with the PM2.5 mass concentration during the fall and winter seasons. Based on these findings, this study develops a simple correction model for ΔNO2 using the PM2.5 mass concentration during the fall and winter seasons. The model-corrected NO2 concentration correlated well with the actual NO2 values with a slope of approximately 1.0 and R² value of 0.98 during the fall and winter seasons.



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