Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects

Abstract

The rapid spread of highly aggressive arboviruses, parasites, and bacteria along with the development of resistance in the pathogens and parasites, as well as in their arthropod vectors, represents a huge challenge in modern parasitology and tropical medicine. Eco-friendly vector control programs are crucial to fight, besides malaria, the spread of dengue, West Nile, chikungunya, and Zika virus, as well as other arboviruses such as St. Louis encephalitis and Japanese encephalitis. However, research efforts on the control of mosquito vectors are experiencing a serious lack of eco-friendly and highly effective pesticides, as well as the limited success of most biocontrol tools currently applied. Most importantly, a cooperative interface between the two disciplines is still lacking. To face this challenge, we have reviewed a wide number of promising results in the field of green-fabricated pesticides tested against mosquito vectors, outlining several examples of synergy with classic biological control tools. The non-target effects of green-fabricated nanopesticides, including acute toxicity, genotoxicity, and impact on behavioral traits of mosquito predators, have been critically discussed. In the final section, we have identified several key challenges at the interface between "green" nanotechnology and classic biological control, which deserve further research attention.

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Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions

Publication date: Available online 27 July 2017
Source:Advanced Drug Delivery Reviews
Author(s): Saeid Amini-Nik, Yusef Yousuf, Marc G. Jeschke
In recent decades, there have been tremendous improvements in burn care that have allowed patients to survive severe burn injuries that were once fatal. However, a major limitation of burn care currently is the development of hypertrophic scars in approximately 70% of patients. This significantly decreases the quality of life for patients due to the physical and psychosocial symptoms associated with scarring. Current approaches to manage scarring include surgical techniques and non-surgical methods such as laser therapy, steroid injections, and compression therapy. These treatments are limited in their effectiveness and regularly fail to manage symptoms. As a result, the development of novel treatments that aim to improve outcomes and quality of life is imperative. Drug delivery that targets the molecular cascades of wound healing to attenuate or prevent hypertrophic scarring is a promising approach that has therapeutic potential. In this review, we discuss current treatments for scar management after burn injury, and how drug delivery targeting molecular signaling can lead to new therapeutic strategies.

Graphical abstract

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Scholar : These new articles for Atmospheric and Oceanic Science Letters are available online

The online platform for Taylor & Francis Online content New for Atmospheric and Oceanic Science Letters and online now on Taylor & Francis Online: Original Articles Projection of the summer northern East Asian low under global warming in CMIP5 models | Zhong-Da Lin & Yuan-Hai Fu Pages: 1-6 | DOI: 10.1080/16742834.2017.1358053 Read selected content from the Journal of Structural Integrity and Maintenance for free! http://ift.tt/2coiFom To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for The Physician and Sportsmedicine are available online

The online platform for Taylor & Francis Online content New for The Physician and Sportsmedicine and online now on Taylor & Francis Online: Clinical Features - Original Research Benefits of physical activities centered on the trunk for pregnant women Eric Watelain http://ift.tt/2ve6zHo, Antonio Pinti, Racha Doya, Cyril Garnier, Hechmi Toumi & Samuel Boudet http://ift.tt/2w5V15d Pages: 1-10 | DOI: 10.1080/00913847.2017.1351286 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for The American Journal of Drug and Alcohol Abuse are available online

The online platform for Taylor & Francis Online content New for The American Journal of Drug and Alcohol Abuse and online now on Taylor & Francis Online: Original Articles Effects of propofol on conditioned place preference in male rats: involvement of nitrergic system Andleeb Shahzadi PhD, Tuğçe Uskur DVM, A. Gökhan Akkan PhD, Burcu Çevreli DVM & Tayfun Uzbay PhD Pages: 1-8 | DOI: 10.1080/00952990.2017.1344681 Transgenerational modification of hippocampus TNF-α and S100B levels in the offspring of rats chronically exposed to morphine during adolescence Jamal Amri MSc, Mehdi Sadegh PhD http://ift.tt/2ve1E9s, Neda Moulaei MSc & Mohammad Reza Palizvan PhD Pages: 1-8 | DOI: 10.1080/00952990.2017.1348509 FREE ACCESS: Health Care for Women International: Research on Women's Health in Africa: Issues, Challenges & Opportunities To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources

Publication date: October 2017
Source:Data in Brief, Volume 14
Author(s): Bi Zhao, Bin Xue
MiRNAs regulate gene expression by forming base pairing with mRNAs to inhibit the translation of those mRNAs. In many mammalian genomes each, about 2000 miRNAs were found to regulate roughly 60% of all the genes in that genome. Many experimental validations and computational predictions have been done on miRNA:mRNA interactions. Nonetheless, the interactions from different sources are not always consistent. In this study, we integrated multiple online resources, including mirTarBase, TarBase, miRanda, miRDB, PITA, and TargetScan, and developed eleven large-scale datasets containing miRNA:mRNA interactions that are consistent among a specific subgroup of above-mentioned online resources. In addition, a new integrated confidence score was designed to show the significance for all the miRNA:mRNA interactions.



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Plant-based remedies for wolf bites and rituals against wolves in the Iberian Peninsula: Therapeutic opportunities and cultural values for the conservation of biocultural diversity

Publication date: 14 September 2017
Source:Journal of Ethnopharmacology, Volume 209
Author(s): José A. González, Ana Maria Carvalho, José Ramón Vallejo, Francisco Amich
Ethnopharmacological relevanceCombined approaches to local knowledge and folk plant use improve awareness and promote effective strategies for the conservation of significant biocultural patrimony. Moreover, the information reported might be the basis for further appropriate phytochemical and pharmacological research. Therefore we provide an insight into traditional herbal remedies and practices for healing bite injuries in humans and domestic animals caused by the Iberian wolf. Wolf bites are associated with inflammatory processes and rabies is a potential complicationAimsThis paper describes and summarises the medicinal-veterinary empirical and ritual uses of the Iberian flora for wolf injuries and reviews the ethnopharmacological data of specific plants that are already published. The Iberian wolf is a critically endangered subspecies of the grey wolf. Livestock attacks attributed to wolves are increasingly frequent in the Iberian Peninsula, resulting in serious social problems. Interesting strategies for Iberian wolf conservation might be related to traditional grazing practices that are deeply linked with empirical knowledge and local practices passed on by oral tradition, which are also vulnerable now.Materials and methodsBased on documentary sources from the beginning of the twentieth century to the present, we systematically searched old monographs, regional documents, technical papers, project reports, as well as the international and national databases and the available scientific literature, without restrictions regarding the language of the publications consulted.ResultsA total of 39 remedies for healing wolf bite injuries in humans and domestic animals was reported, highlighting the medicinal use of 33 species of vascular plants, mostly wild herbs, belonging to 18 botanical families. The use of wood ashes was also reported. The number of use-reports found represents a very high number considering similar European studies. Leaves were the predominant plant part mentioned. Boiling plant materials in water for topical uses was the most frequent method of preparation found. Some traditional remedies combined two or more plant species in order to potentiate their effects. Moreover, some plant-based traditional practices and rituals to ward off wolves and to prevent wolf attacks were also documented. In these practices eleven other species (belonging to seven more families) were used.ConclusionsDespite the decline of the Iberian wolf over the last few decades, wolves are still in the imaginary of rural communities that perceive this large carnivore as both a diabolic creature and a mythic and benign animal. Wolf-related cultural heritage is of great interest in terms of conservation strategies. This review emphasises the importance of local knowledge and provides useful information about several potential sources of phytochemicals and their claimed therapeutic effects, aiming at contributing to the conservation and appreciation of the Iberian biocultural heritage.

Graphical abstract

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Effect of cortex mori on pharmacokinetic profiles of main isoflavonoids from pueraria lobata in rat plasma

Publication date: 14 September 2017
Source:Journal of Ethnopharmacology, Volume 209
Author(s): Bingxin Xiao, Zengxian Sun, Shu yang Sun, Jie Dong, Yanli Li, Shan Gao, Jie Pang, Qi Chang
Ethnopharmacological relevanceRadix pueraria (the root of pueraria lobata (Wild.) Ohwi.), which contains a class of isoflavonoids as the main active components, as well as cortex mori (the root bark of Morus alba L), which contains abundant active alkaloids, have been employed for the treatment of diabetes in traditional Chinese medicine for centuries. In previous studies, pharmacodynamic synergistic reactions have been observed in compatible application of pueraria lobata isoflavonoids extracts (PLF) and cortex mori alkaloids extracts (CME) for inhibiting α-glycosidase activity. It has also been demonstrated that PLF can effectively slow down the absorption of active alkaloid from CME, so as to produce a higher effective concentration in small intestine for depressing the elevation of postprandial blood glucose through inhibiting α-glycosidase activity.Aim of the studyIn this study, the hypoglycemic effect of PLF, CME or CME-PLF mixture (the mixture of CME and PLF at a ratio of 1:6.3) was further evaluated through in vivo glucose tolerance studies. And the effect of CME on pharmacokinetic profiles of main isoflavonoids from PLF in rat plasma was investigated to further underlie compatibility mechanism of the two herbs.Materials and methodsFour groups of rats received an oral dose of starch solution alone or simultaneously with drugs by gavage feeding. The blood samples were collected to determine glucose concentrations by glucose oxidase method. In addition, another two groups of rats were orally administered with PLF or CME-PLF. The plasma samples were collected and assayed using an LC/MS/MS method for comparatively pharmacokinetic studies of five main isoflavonoids.ResultsFor starch loading, co-administration of CME-PLF resulted in more potent inhibition effects on glucose responses compared to those by CME or PLF in rat. The isoflavonoids from PLF were rapidly absorbed, presenting similarly low concentrations in plasma. When CME was added, the Cmax and AUC of all the five isoflavonoids were increased. A phenomenon of double peaks was found for all analysts. The elimination rates of all the detected isoflavonoids were also slowed down with extension of t1/2.ConclusionsCME has been found to increase the absorption and delay the elimination of main isoflavonoids from PLF, which might result in higher concentrations of circulating active compounds for anti diabetes.

Graphical abstract

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Acute and sub-chronic toxicity studies of the aqueous extract from leaves of Cistus ladaniferus L. in mice and rats

Publication date: 14 September 2017
Source:Journal of Ethnopharmacology, Volume 209
Author(s): Mohamed El Kabbaoui, Alae Chda, Jamila El-Akhal, Ouarda Azdad, Najlae Mejrhit, Lotfi Aarab, Rachid Bencheikh, Abdelali Tazi
Ethnopharmacological relevanceCistus ladaniferus L. (C.ladaniferus) (Cistaceae) is an aromatic shrub native to the Mediterranean region. The leaves are widely used in traditional medicine throughout Morocco for the treatment of various diseases including, diabetes, diarrhea, inflammation, and skin ailments. However, to the best of our knowledge, no systematic study concerning its toxicity profile has been reported.Aim of the studyThe study carried out evaluates the potential toxicity of the aqueous extract from leaves of the C.ladaniferus (CL extract) shrub, through the method of acute and sub-chronic oral administration in mice and rats.Materials and methodsDuring the acute toxicity study, male and female mice were orally administrated with CL aqueous extract at single doses of 500, 1000, 2000, 3000 and 5000mg/kg (n = 5/group/sex). Abnormal behavior, toxic symptoms, weight, and death were observed for 14 consecutive days to assess the acute toxicity. During the sub-chronic toxicity study, the aqueous extract was administered orally at doses of 500, 700 and 1000mg/kg (n = 6/group) daily to Wistar rats of both sexes for 90 days. The general behavior of the rats was observed daily, and their body weight was recorded weekly. A urinalysis, biochemical analysis, hematological analysis, macroscopic examination and histopathological examination of several organs were conducted at the end of the treatment period.ResultsDuring the acute toxicity test, when mice were administered doses of 3000 and 5000mg/kg, the CL extract produced a 10–30% mortality rate, respectively, and induced signs of toxicity. However, no mortality or adverse effect was noted at the doses of 1000 and 2000mg/kg. The median lethal dose (LD50) of the extract was estimated to be more than 5000mg/kg. In the subchronic study, the CL extract induced no mortality or treatment-related adverse effects with regard to body weight, general behavior, relative organ weights, urine, hematological, and biochemical parameters. Histopathological examination of vital organs showed normal architecture suggesting no morphological alterations. Moreover, the CL extracts improved lipid profile and exhibited a significant hypoglycemic effect in all doses tested in rats.ConclusionThe results of the present study suggest that treatment with the CL extract for 13 weeks does not appear to produce significant toxicity, except at high dose. Therefore, the use of appropriate levels of the CL extract as a traditional medicine remedies should have a wide margin of safety for its therapeutic use.

Graphical abstract

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Amburana cearensis seed extract protects brain mitochondria from oxidative stress and cerebellar cells from excitotoxicity induced by glutamate

Publication date: 14 September 2017
Source:Journal of Ethnopharmacology, Volume 209
Author(s): Érica Patrícia Lima Pereira, Cleide Santos Souza, Jessika Amparo, Rafael Short Ferreira, Yanier Nuñez-Figueredo, Luzimar Gonzaga Fernandez, Paulo Roberto Ribeiro, Suzana Braga-de-Souza, Victor Diogenes Amaral da Silva, Silvia Lima Costa
Ethnopharmacological relevanceAmburana cearensis (Allemao) A.C.Sm. is a medicinal plant of the Brazilian Caatinga reported to present antioxidant and anti-inflammatory activity. This study aimed to evaluate the neuroprotective effect of the extracts obtained from the seeds of A. cearensis in primary cultures of cerebellar cells subjected to excitotoxicity induced by glutamate and brain mitochondria submitted to oxidative stress.Materialsand methods: Primary cultures of cerebellar cells were treated with the ethanol (ETAC), hexane (EHAC), dichloromethane (EDAC) and ethyl acetate (EAAC) extracts of the seeds of A.cearensis and subjected to excitotoxicity induced by glutamate (10µM). Mitochondria isolated from rat brains were submitted to oxidative stress and treated with ETAC.ResultsOnly the EHAC extract reduced cell viability by 30% after 72h of treatment. Morphological analyses by Immunofluorescence showed positive staining for glutamine synthetase, β-III tubulin, GFAP and IBA1 similar to control cultures, indicating a better preservation of astrocytes, neurons and microglia, after excitotoxic damage induced by glutamate in cerebellar cultures treated with the extracts. The ETAC extract also protected mitochondria isolated from rat brains from oxidative stress, reducing the swelling, dissipation of the membrane potential, ROS production and calcium influx.ConclusionThus, this study suggests that the seed extracts from A. Cearensis exhibit neuroprotective potential against oxidative stress and excitotoxicity induced by glutamate and can be considered a potential therapeutic agent in the treatment of neurodegenerative diseases.

Graphical abstract

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A standardized extract of the fruit of Hovenia dulcis alleviated alcohol-induced hangover in healthy subjects with heterozygous ALDH2: A randomized, controlled, crossover trial

Publication date: 14 September 2017
Source:Journal of Ethnopharmacology, Volume 209
Author(s): Hoejin Kim, You Jin Kim, Hye Yun Jeong, Ji Yeon Kim, Eun-Kyung Choi, Soo Wan Chae, Oran Kwon
Ethnopharmacological relevanceHovenia dulcis, known as the oriental raisin tree, is mainly found in East Asia. It has long been used as traditional folk remedies for alcohol intoxication.Aim of the studyTo examine the anti-hangover effect of Hovenia dulcis Thunb. fruit extract (HDE) in a randomized controlled crossover trial.Materials and methodsTwenty-six eligible male adults with heterozygous ALDH2 (23.7±0.3 years old) consumed 360mL of Korean Soju (50g alcohol) together with HDE (2460mg) or matched placebo with subsequent crossover. The blood samples were taken at baseline and 1, 4, and 12h post-treatment.ResultsBlood alcohol, acetaldehyde, and total hangover scores were highest at 1h post-treatment with no difference between groups, but declines in hangover symptom scores were significant in the HDE group compared to the placebo group. Significant differences between groups were also observed on interleukin (IL)-6, IL-10, IL-10/IL-6 ratio, and aspartate aminotransferase levels, but not on endotoxins. Pearson correlation analysis revealed a positive correlation between total hangover symptom scores and IL-6 and IL-10 level. Further analyses by CYP2E1 polymorphism at rs10776687, rs2031920, rs3813867, and rs4838767 alleles showed a reversed association, suggesting that CYP2E1 polymorphism might be an effect modifier.ConclusionsThe results suggest that a favorable effect of HDE on alcohol hangovers might be associated with enhancing homeostatic regulation of inflammatory response. The magnitude of impact might be different in the presence of CYP2E1 polymorphism.

Graphical abstract

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An unusual cysteine VL87 affects the antibody fragment conformations without interfering with the disulfide bond formation

Publication date: October 2017
Source:Molecular Immunology, Volume 90
Author(s): Carolina Attallah, María Fernanda Aguilar, A. Sergio Garay, Fernando E. Herrera, Marina Etcheverrigaray, Marcos Oggero, Daniel E. Rodrigues
The Cys residues are almost perfectly conserved in all antibodies. They contribute significantly to the antibody fragment stability. The relevance of two natural contiguous Cys residues of an anti-recombinant human-follicle stimulation hormone (rhFSH) in a format of single-chain variable fragment (scFv) was studied. This scFv contains 5 Cys residues: VH22 and VH92 in the variable heavy chain (VH) and VL23, VL87 and VL88 in the variable light chain (VL). The influence of two unusual contiguous Cys at positions VL87 and VL88 was studied by considering the wild type fragment and mutant variants: VL-C88S, VL-C87S, VL-C87Y. The analysis was carried out using antigen-binding ability measurement by indirect specific ELISA and a detailed molecular modeling that comprises homology methods, long molecular dynamics simulations and docking. We found that VL-C87 affected the antibody fragment stability without interfering with the disulfide bond formation. The effect of mutating the VL-C87 by a usual residue at this position like Tyr caused distant structural changes at the VH region that confers a higher mobility to the VH-CDR2 and VH-CDR3 loops improving the scFv binding to the antigen.



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Scholar : These new articles for Addiction Research & Theory are available online

The online platform for Taylor & Francis Online content New for Addiction Research & Theory and online now on Taylor & Francis Online: Original Article Mapping social identity change in online networks of addiction recovery David Best, Ana-Maria Bliuc, Muhammad Iqbal, Katie Upton & Steve Hodgkins Pages: 1-11 | DOI: 10.1080/16066359.2017.1347258 FREE ACCESS: Health Care for Women International: Research on Women's Health in Africa: Issues, Challenges & Opportunities To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Mutant p53 as a target for cancer treatment

Publication date: September 2017
Source:European Journal of Cancer, Volume 83
Author(s): Michael J. Duffy, Naoise C. Synnott, John Crown
TP53 (p53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumours. However, in some of the most difficult-to-treat cancers such as high-grade serous ovarian cancers, triple-negative breast cancers, oesophageal cancers, small-cell lung cancers and squamous cell lung cancers, p53 is mutated in at least 80% of samples. Clearly, therefore, mutant p53 protein is an important candidate target against which new anticancer treatments could be developed. Although traditionally regarded as undruggable, several compounds such as p53 reactivation and induction of massive apoptosis-1 (PRIMA-1), a methylated derivative and structural analogue of PRIMA-1, i.e. APR-246, 2-sulfonylpyrimidines such as PK11007, pyrazoles such as PK7088, zinc metallochaperone-1 (ZMC1), a third generation thiosemicarbazone developed by Critical Outcome Techonologies Inc. (COTI-2) as well as specific peptides have recently been reported to reactive mutant p53 protein by converting it to a form exhibiting wild-type properties. Consistent with the reactivation of mutant p53, these compounds have been shown to exhibit anticancer activity in preclinical models expressing mutant p53. To date, two of these compounds, i.e. APR-246 and COTI-2 have progressed to clinical trials. A phase I/IIa clinical trial with APR-246 reported no major adverse effect. Currently, APR-246 is undergoing a phase Ib/II trial in patients with advanced serous ovarian cancer, while COTI-2 is being evaluated in a phase I trial in patients with advanced gynaecological cancers. It remains to be shown however, whether any mutant p53 reactivating compound has efficacy for the treatment of human cancer.



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Addressing the best treatment for non-clear cell renal cell carcinoma: A meta-analysis of randomised clinical trials comparing VEGFR-TKis versus mTORi-targeted therapies

Publication date: September 2017
Source:European Journal of Cancer, Volume 83
Author(s): Chiara Ciccarese, Roberto Iacovelli, Matteo Brunelli, Francesco Massari, Davide Bimbatti, Emanuela Fantinel, Vincenzo De Marco, Antonio Benito Porcaro, Guido Martignoni, Walter Artibani, Giampaolo Tortora
AimNon-clear cell renal cell carcinoma (nccRCC) tumours include a heterogeneous group of malignancies that profoundly differ in terms of morphology, genetic profile, clinical behaviour and prognosis. The optimal treatment algorithm for nccRCC is still unknown and derived mainly from evidence available for ccRCC, being therefore represented by targeted agents against vascular endothelial growth factor and mammalian target of rapamycin (mTOR) pathways.We aimed to compare the efficacy of vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKis) and mTOR inhibitors (mTORi) for the treatment of nccRCC patients.MethodsSearching the MEDLINE/PubMed, Cochrane Library and American Society of Clinical Oncology Meeting abstracts prospective studies were identified. Data extraction was conduced according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.The measured outcomes were progression-free survival (PFS), overall survival (OS) and the overall response rate (ORR).ResultsFour randomised controlled trials were selected for final analysis, with a total of 332 patients evaluable for PFS. Treatment with TKi significantly reduced the risk of progression compared with mTORi (hazard ratio [HR] = 0.71; 95% confidence interval [CI] 0.60–0.84; p < 0.0001). This difference remained significant when sunitinib was compared with everolimus in first-line setting (HR = 0.67; 95% CI, 0.56–0.80; p < 0.00001). In the 332 patients evaluable for OS, no significant difference was found between TKi and mTORi (HR = 0.86; 95% CI, 0.67–1.12; p = 0.27). In the 176 evaluable patients, TKis therapy did not improve the ORR when compared with mTORi (relative risk [RR] = 2.21; 95% CI, 0.87–5.60; p = 0.09), even if treatment with sunitinib doubled the probability of achieving a tumour response.ConclusionsTreatment with TKis significantly improves PFS, but not OS, when compared with mTORi. Moreover, sunitinib as first-line therapy reduces the risk of progression compared with everolimus; therefore, supporting the standard treatment paradigm broadly used for ccRCC patients. The relatively modest efficacy of available targeted therapies reinforces the need of future histology based, molecular driven therapeutic paradigm.



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Scholar : These new articles for Autophagy are available online

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The online platform for Taylor & Francis Online content New for Autophagy and online now on Taylor & Francis Online: Autophagic Punctum Lift and cut: Anti-host autophagy mechanism of Legionella pneumophila Supansa Pantoom, Aimin Yang & Yao-Wen Wu http://ift.tt/2eTAcGN Pages: 1-3 | DOI: 10.1080/15548627.2017.1327943 Toolbox Accumulation of undegraded autophagosomes by expression of dominant-negative STX17 (syntaxin 17) mutants Masaaki Uematsu, Taki Nishimura, Yuriko Sakamaki, Hayashi Yamamoto & Noboru Mizushima Pages: 1-13 | DOI: 10.1080/15548627.2017.1327940 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Spanish Journal of Finance and Accounting / Revista Española de Financiación y Contabilidad are available online

The online platform for Taylor & Francis Online content New for Spanish Journal of Finance and Accounting / Revista Española de Financiación y Contabilidad and online now on Taylor & Francis Online: Article The dual role of management accounting and control systems in exports: drivers and payoffs Jacobo Gomez-Conde http://ift.tt/2w6cdHM & Ernesto Lopez-Valeiras http://ift.tt/2vdLL2v Pages: 1-22 | DOI: 10.1080/02102412.2017.1346914 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Asian Englishes are available online

The online platform for Taylor & Francis Online content New for Asian Englishes and online now on Taylor & Francis Online: Original Articles Split infinitives across World Englishes: a corpus-based investigation Wilkinson Daniel Wong Gonzales http://ift.tt/2vdFnIK & Shirley N. Dita Pages: 1-26 | DOI: 10.1080/13488678.2017.1349858 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Advanced Robotics are available online

The online platform for Taylor & Francis Online content New for Advanced Robotics and online now on Taylor & Francis Online: Full Paper Spatial representation of context-dependent sentences and its application to sentence generation Tomoyuki Maekawa & Wataru Takano Pages: 1-11 | DOI: 10.1080/01691864.2017.1351392 Routledge Psychology 2017 sponsor of BPS #PsychCrunch podcasts. Access 25 journal articles: http://bit.ly/psychcrunch2017 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Gastric Perforation after Duodenopancreatectomy

Publication date: Available online 27 July 2017
Source:Medical Mycology Case Reports
Author(s): Henrik Bäcker, Frank PJ Beeres, Marco Rossi, Andreas Scheiwiller
Fungal and bacterial infections are often which may cause sepsis. Mucormycosis is an unfrequent, but often life-threatening disease. A timely diagnosis and treatment is the cornerstone of success. An increase in incidence can be expected, given an aging population and increasing incidence of obesity, diabetes and cancer.We present a rare case where early diagnosis has helped to treat the patient mainly with antifungal therapy as surgical therapy has had high risk of complications.



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