A rare case of topical methazolamide ophthalmic solution causing death due to toxic epidermal necrolysis

http://ift.tt/2myZmvI

Comparative study of selenium and selenium nanoparticles with reference to acute toxicity, biochemical attributes, and histopathological response in fish

Abstract

Recent studies have demonstrated that selenium (Se) and selenium nanoparticles (Se-NPs) exhibited toxicity at a higher concentration. The lethal concentration of Se and Se-NPs was estimated as 5.29 and 3.97 mg/L at 96 h in Pangasius hypophthalmus. However, the effect of different definite concentration of Se (4.5, 5.0, 5.5, and 6.0 mg/L) and Se-NPs (2.5, 3.0, 3.5, and 4.0 mg/L) was decided for acute experiment. Selenium and Se-NPs alter the biochemical attributes such as anti-oxidative status [catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST) activities], neurotransmitter enzyme, cellular metabolic enzymes, stress marker, and histopathology of P. hypophthalmus in a dose- and time-dependent manner. CAT, SOD, and GST were significantly elevated (p < 0.01) when exposed to Se and Se-NPs, and similarly, a neurotransmitter enzyme (acetylcholine esterase (AChE)) was significantly inhibited in a time- and dose-dependent manner. Further, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and malate hydrogenase were noticeably (p < 0.01) affected by Se and Se-NPs from higher concentration to lower concentration. Stress markers such as cortisol and HSP 70 were drastically enhanced by exposure to Se and Se-NPs. All the cellular metabolic and stress marker parameters were elevated which might be due to hyperaccumulation of Se and Se-NPs in the vital organ and target tissues. The histopathology of liver and gill was also altered such as large vacuole, cloudy swelling, focal necrosis, interstitial edema, necrosis in liver, and thickening of primary lamellae epithelium and curling of secondary lamellae due to Se and Se-NP exposure. The study suggested that essential trace element in both forms (inorganic and nano) at higher concentration in acute exposure of Se and Se-NPs led to pronounced deleterious alteration on histopathology and cellular and metabolic activities of P. hypophthalmus.

http://ift.tt/2Db47op

Stage-specific therapeutic strategies of medication-related osteonecrosis of the jaws: a systematic review and meta-analysis of the drug suspension protocol

Abstract

Objective

The most debated topic about medication-related osteonecrosis of the jaws (MRONJ) is its therapy, as there are no definitive guidelines. The aims of this systematic review were (a) to outline the best therapeutic approach according to the stage at diagnosis and (b) to perform a meta-analysis to assess whether the drug-holiday protocol may be or not an effective method in the management of MRONJ patients.

Materials and methods

The systematic review was performed following the PRISMA principles. Results were screened according to inclusion and exclusion criteria regarding staging before/after treatment, follow-up, and information provided by the authors. For statistical analysis, linear variables are reported as means and standard deviations, medians, and inter-quartile range (IQR); normality of data, according to the distribution of complete healing (primary outcome variable), was assessed with the Kolmogorov-Smirnov test. A p value < 0.05 was considered statistically significant for all tests.

Results

Thirteen studies were selected out of 1480. None of them was case-controlled or randomized. Conservative approach showed good results at early stages, but heterogeneous result at advanced stages (100% stage 0, stage I range 81–97%, stage II range 63.6–100%, stage III 73%). Surgical approach showed heterogeneous results at all stages (stage I range 0–100%, stage II range 52–100%, stage III range 50–100%). Statistical analysis showed a significantly higher prevalence of completely healed sites in patients who followed the drug-holiday protocol.

Conclusions

The results suggest that the current stage-specific approach for MRONJ therapy is based on a sound clinical rationale. Conservative treatment appears to yield better outcomes at early stages, while further investigations are needed to elucidate the best protocols for the management of advanced stages. The drug-holiday protocol statistically promotes complete healing after oral surgery procedures but the application should be dictated by the condition of each patient.

Clinical relevance

At present, early MRONJ stages should be primarily treated by means of a conservative approach while more advanced stages must be carefully evaluated. Individual decisions should be made for every single case even with respect to the drug-holiday protocol.

http://ift.tt/2qYT3WN

Diagnostic Usefulness of Combination of Diffusion-weighted Imaging and T2WI, Including Apparent Diffusion Coefficient in Breast Lesions

Publication date: Available online 12 January 2018
Source:Academic Radiology
Author(s): Keum Won Kim, Cherie M. Kuzmiak, Young Joong Kim, Jae Young Seo, Hae Kyoung Jung, Mu-Sik Lee
PurposeThis study aimed to compare the diagnostic values of a combination of diffusion-weighted imaging and T2-weighted imaging (DWI-T2WI) with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and to evaluate the correlation of DWI with the histologic grade in breast cancer.Materials and MethodsThis study evaluated a total of 169 breast lesions from 136 patients who underwent both DCE-MRI and DWI (b value, 1000s/mm²). Morphologic and kinetic analyses for DCE-MRI were classified according to the Breast Imaging-Reporting and Data System. For the DWI-T2WI set, a DWI-T2WI score for lesion characterization that compared signal intensity of DWI and T2WI (benign: DWI-T2WI score of 1, 2; malignant: DWI-T2WI score of 3, 4, 5) was used. The diagnostic values of DCE-MRI, DWI-T2WI set, and combined assessment of DCE and DWI-T2WI were calculated.ResultsOf 169 breast lesions, 48 were benign and 121 were malignant (89 invasive ductal carcinoma, 24 ductal carcinoma in situ, 4 invasive lobular carcinoma, 4 mucinous carcinoma). The mean apparent diffusion coefficient (ADC) of invasive ductal carcinoma (0.92 ± 0.19 × 10⁻³ mm²/s) and ductal carcinoma in situ (1.11 ± 0.13 × 10⁻³ mm²/s) was significantly lower than the value seen in benign lesions (1.36 ± 0.22 × 10⁻³ mm²/s). The specificity, positive predictive value (PPV), and accuracy of DWI-T2WI set and combined assessment of DCE and DWI-T2WI (specificity, 87.5% and 91.7%; PPV, 94.3% and 96.2%; accuracy, Az = 0.876 and 0.922) were significantly higher than those of the DCE-MRI (specificity, 45.8%; PPV, 81.7%; accuracy, Az = 0.854; P < .05). A low ADC value and the presence of rim enhancement were associated with a higher histologic grade cancer (P < .05).ConclusionCombining DWI, T2WI, and ADC values provides increased accuracy for differentiation between benign and malignant lesions, compared with DCE-MRI. A lower ADC value was associated with a higher histologic grade cancer.



http://ift.tt/2FxKcOR

Are Sex Steroid Hormones Influencing Periodontal Conditions? A Systematic Review

Abstract

Purpose of Review

The pulsatile fashion of the release of sex steroid hormones has an impact on periodontium. The aim of this systematic review was to determine whether sex steroid hormones influence periodontal diseases or not.

Recent Findings

MEDLINE via OVID, EMBASE, and the Cochrane Database updated until July 2017 were searched and, particularly, the papers published over the past 5 years were reviewed.

Summary

The evidence is more supportive towards the effect of sex steroid hormone perturbations on an existing periodontal disease rather than the initiation of disease. Examination of potential diagnostics for preventive or therapeutic applications is needed in order to decrease the composite risks arising from the hormonal changes themselves. Also, further clinical trials comparing sex steroid hormone exposure on patients with similar baseline periodontal conditions are emerging in order to understand the causal mechanisms between the two, eventually, helping to make clearer clinical recommendations and guidelines for hormone-dominated periods in both men and women.

http://ift.tt/2D0uytR

Dermatomyositis: histopathologic findings of parakeratosis and dermal edema revisited

Abstract

The cutaneous manifestations of dermatomyositis range from classical in the case of heliotrope rash and Gottron papules to less common papulosquamous and edematous/vesiculobullous lesions; histopathologic descriptions are dominated by interface dermatitis. We present a case of dermatomyositis with a combination of common and rare skin findings, both clinically and histologically. Increased awareness of papulosquamous and edematous lesions of dermatomyositis can help direct patient care. Although uncommon, confluent parakeratosis and dermal edema can be manifestations of dermatomyositis.

http://ift.tt/2qYW7C5

A case of radiation induced osteosarcoma of the skull presenting as a cutaneous epidermotropic tumour with a short latent period

Abstract

Radiation induced sarcoma is an unusual but well documented tumor. The frequency of radiation induced sarcoma of the head and neck region has been reported as 0.143%. In the literature the median interval between irradiation and development of sarcoma is 11 years. Cases of RIS with a short latent period i.e. less than four years are rare. We report a case of a 34 year-old female who developed an osteosarcoma of the scalp, over a previous craniotomy scar, three years after excision of a frontal anaplastic oligodendroglioma which had been followed by a course of 6 weeks radiotherapy (58 Gy) and 6 cycles of Temozolomide. The histological features were those of a high-grade osteosarcoma with epidermotropism of tumor cells. Lymph nodes were partially replaced by high-grade metastatic osteosarcoma with extra-nodal lymphatic tumor thrombi. To our knowledge the only other case report of post-radiation osteosarcoma with a short latency period was a case of osteosarcoma in the craniofacial bone three years after radiotherapy for maxillary squamous cell carcinoma. The histological finding of prominent replacement of the epidermis by osteosarcoma has not been reported before.

http://ift.tt/2myVRoP

The computed tomography adrenal wash-out analysis properly classifies cortisol secreting adrenocortical adenomas

Abstract

Purpose

Adrenocortical lesions are characterized through imaging, hormonal and histopathological analysis. Our aim was to compare the radiological features of adrenocortical lesions with their cortisol-secreting status and histopathological Weiss score.

Methods

Seventy five patients operated between 2004 and 2016 in the University Hospital of Nancy for either adrenocortical carcinomas (ACC) or adrenocortical adenomas (ACA) were enrolled in this study. We collected cortisol parameters, Computed Tomography (CT) scans (unenhanced density, wash-out (WO) analysis) and ¹⁸F-Fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) datas. The histopathological Weiss score ultimately differentiates ACA (score ≤ 2) from ACC (score ≥ 3). One-way ANOVA, Fisher's exact and unpaired t tests were used for statistical analysis with significancy reached at p < 0.05.

Results

There were 23 ACC and 52 ACA with 40 patients (53%) who had an autonomous secretion of cortisol. On CT scan, ACC were larger compared to ACA (108 vs. 37 mm, p < 0.0001). A roughly similar proportion of cortisol-secreting (22/25) and non-secreting (15/19) ACA were atypical (i.e., unenhanced density value ≥ 10 Hounsfield Units [HU]), however 85% of cortisol-secreting vs. 40% of non-secreting ACA were classified as benigns by the relative WO analysis (p = 0.08). Likewise, there was a trend for a higher ¹⁸F-FDG uptake in cortisol-secreting ACA compared to non-secreting ACA (p = 0.053).

Conclusions

The relative adrenal WO analysis consolidates the benign nature of an ACA, especially in case of cortisol oversecretion, a condition known to compromise the diagnostic accuracy of the 10 HU unenhanced CT attenuation threshold.

http://ift.tt/2DnUmkt

Scholar : ΑΚΟΗ - νέα αποτελέσματα

[PDF] Διερεύνηση αντιλήψεων και αναγκών των εκπαιδευτικών πρωτοβάθμιας εκπαίδευσης όσον αφορά την αξιοποίηση της τέχνης στην εκπαιδευτική διεργασία

Π Κόττου - 2017

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΠΕΙΡΑΙΩΣ ΤΜΗΜΑ ΨΗΦΙΑΚΩΝ ΣΥΣΤΗΜΑΤΩΝ ΠΡΟΓΡΑΜΜΑ
ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ: «Ψηφιακά Συστήματα και Υπηρεσίες» Κατεύθυνση: Ηλεκτρονική
Μάθηση Διερεύνηση αντιλήψεων και αναγκών των Εκπαιδευτικών …

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : Decannulation - νέα αποτελέσματα

A novel strategy for cardiopulmonary support during lung transplantation

R Fernandez, MM DeCamp, A Bharat - Journal of Thoracic Disease, 2018

… The cannula was left in place to provide ongoing RV support and the patient was successfully
decannulated at bedside on post-operative day (POD) 2. Lack of arterial cannulation,
percutaneous access, and bedside decannulation are bene ts of this strategy, rendering this …

Double blind randomized control trial to evaluate the efficacy of ketoprofen patch to attenuate pain during venous cannulation.

S Kumar, O Sanjeev, A Agarwal, C Shamshery… - Korean Journal of Pain, 2018

… The venipuncture site was assessed for the presence of skin erythema, swelling and rashes
at 12 h, 24 h and at the time of decannulation. Results: Incidence of pain was 100% (94/94)
in the control group as compared to 93% (85/91) in the ketoprofen group …

Staged Palliation of Cyanotic Obstructive Lesions With a Modified Right Ventricular Outflow Procedure

SP Batlivala, MK Hood, J Dodge-Khatami, D Shakti… - World Journal for Pediatric …, 2018

Background: Traditional palliation for biventricular cyanotic congenital heart lesions often
involves staging with systemic-to-pulmonary arterial shunts to secu...

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα

Original Contributions 1 Physical Examination is the Best Predictor of the Need for Abdominal Surgery in Children Following Motor Vehicle Collision

MOUS Venipuncture - The Journal of Emergency Medicine, 2018

… Tsai e7 Male with Severe Hypertension and Dyspnea Nubia Seyoum, Semhar Z.
Tewelde, Zachary DW Dezman e9 Benign Migratory Glossitis Eric T. Stoopler,
Katherine France, David Ojeda, Thomas P. Sollecito e11 Primary …

[HTML] Cheilitis

A Gharbi, W Hafsi - 2017

… Nutritional Deficiency Cheilitis. Several nutritional deficiencies such as avitaminosis B2, B9,
B12, scurvy (vitamin C), iron deficiency, or zinc deficiency may cause exfoliative cheilitis
associated with other oral manifestations (stomatitis, erythematous glossitis) …

Nutrition Therapy in Acute and Chronic Liver Failure

PA Codner, B Taylor, JJ Patel - Hepatic Critical Care, 2018

… Deficiencies of water-soluble B vitamins and vitamin C may manifest as physical findings in or
around the oral cavity as angular stomatitis, cheilosis, glossitis, and/or bleeding gums. More severe
deficiencies may lead to neurological disorders such as ataxia and confusion …

[PDF] Glucagonoma and the glucagonoma syndrome

X Song, S Zheng, G Yang, G Xiong, Z Cao, M Feng… - Oncology Letters

… The incidence of typical clinical findings were as follows: NME, 82.4% (350/425); diabetes, 68.5%
(291/425); weight loss, 60.2% (256/425); anemia, 49.6% (211/425); and glossitis or stomatitis
or cheilitis, 41.2% (175/425) … Glossitis/stomatitis/cheilitis 175 41.2 92 39.5 83 43.2 …

[HTML] Respiratory disease in ball pythons (Python regius) experimentally infected with ball python nidovirus

LL Hoon-Hanks, ML Layton, RJ Ossiboff, JSL Parker… - Virology, 2018

… cavity and cranial esophagus. Histologically, there was moderate chronic-active
mucinous rhinitis, stomatitis, glossitis, tracheitis, and cranial esophagitis with variable
epithelial proliferation. Inflammatory infiltrates were mixed …

[HTML] Komplexes Beschwerdebild–langer Leidensweg

ZP erhalten ein Stipendium

Zahnmedizin: Alterszahnmedizin; Ästhetische Zahnheilkunde; Chirurgie; Digitale
Zahnmedizin; Endodontie; Fortbildung aktuell; Funktionsdiagnostik & -therapie;
Implantologie; Interdisziplinär; Kieferorthopädie; Parodontologie; Prävention …

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ

[HTML] Cheilitis

A Gharbi, W Hafsi - 2017

… infectious agent (EM) or drug (SJS). Oral involvement is very evocative. It presents
as erosive and crusty cheilitis associated with diffuse erosive stomatitis. Drug-induced
Cheilitis. Retinoid treatments (isotretinoin, acitretin, alitretinoin …

[HTML] IRF1 up-regulates isg15 gene expression in dsRNA stimulation or CSFV infection by targeting nucleotides− 487 to− 325 in the 5′ flanking region

XQ Li, XN Li, JJ Liang, XB Cai, Q Tao, YX Li, Q Qin… - Molecular Immunology, 2018

… that porcine IRF1 exhibits antiviral activity against several swine viruses, including
swine influenza virus (SIV), transmissible gastroenteritis virus (TGEV), vesicular
stomatitis virus (VSV), and pseudorabies virus (PRV) (Li et al., 2015) …

LPA-induced migration of ovarian cancer cells requires activation of ERM proteins via LPA 1 and LPA 2

J Park, JH Jang, S Oh, M Kim, C Shin, M Jeong, K Heo… - Cellular Signalling, 2018

… PLC, phospholipase C; ROCK, Rho-associated kinase; VSVG, vesicular stomatitis virus
G-protein. Keywords … An anti-vesicular stomatitis virus G-protein (VSVG) antibody was
purchased from Sigma-Aldrich. 2.2. Cell culture and transfection …

Neoadjuvant treatment with trastuzumab and pertuzumab plus palbociclib and fulvestrant in HER2-positive, ER-positive breast cancer (NA-PHER2): an exploratory …

L Gianni, G Bisagni, M Colleoni, L Del Mastro… - The Lancet Oncology, 2018

… The most frequent grade 3 adverse events were neutropenia (ten [29%]), diarrhoea (five [14%]),
and stomatitis, increased alanine aminotransferase, and hypersensitivity reactions (one [3%]
of each event) … Fatigue, 5 (14%), 0, 0. Nausea, 5 (14%), 0, 0. Stomatitis, 3 (9%), 1 (3%), 1 …

Feline chronic gingivostomatitis and cell therapy.

J Villatoro, G Fariñas, R Becerra - Argos-Informativo Veterinario, 2017

The aetiology, pathogenesis, clinical signs, diagnosis and use of mesenchymal stem cell
immunotherapy in feline chronic gingivostomatitis are described.

Die Homöopathie in der Klinik: Homöopathische Sprechstunde für Frauen mit Krebserkrankung im Hamburger Agaplesion Diakonieklinikum

S Jahn - Zeitschrift für Klassische Homöopathie, 2017

… Meiner Erfahrung nach kommt es selten zu gravierenden unerwünschten Wirkungen (schweres
Erbrechen, Stomatitis, Dermatitis, Fatigue), wenn frühzeitig – direkt nach Diagnosestellung und
noch vor der ersten konventionellen Intervention – mit einer (homöopathischen …

[HTML] Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro

B Ganguly, V Umapathi, SK Rastogi - Journal of Animal Science and Technology, 2018

… Nitric oxide (NO) has been shown to inhibit a number of viruses, including Herpes
Simplex virus type 1 [7], Ectromelia virus, Vaccinia virus [15], Vesicular Stomatitis
virus [5], and murine Friend leukemia retrovirus [1]. Lin et al …

The Superiority of Sucrose Cushion Centrifugation to Ultrafiltration and PEGylation in Generating High-Titer Lentivirus Particles and Transducing Stem Cells with …

ME Boroujeni, M Gardaneh - Molecular Biotechnology, 2018

… of the vesicular stomatitis virus (VSV-G) envelope coun- tenances wide host tropism and enhances
stability through downstream processing [2, 3]. Typically, lentivirus produc- tion is facilitated by
transient transfection of HEK293T cells primarily using calcium phosphate [4 …

[HTML] Targeted Treatment With Radio Frequency Ablation for Lingual Tonsil

S Renkonen, AA Mäkitie, L Bäck - Clinical Medicine Insights: Ear, Nose and Throat, 2018

Objectives: Benign enlargement of the lingual tonsils due to various causes may cause symptoms
that warrant treatment. Conventional lingual tonsillectomy remain...

[PDF] Past and Present Overview of "Orf"

A Dalal, V Kumar, D Chaudhary, N Bansal, A Kumar… - Int. J. Curr. Microbiol. App …, 2017

… Poxviridae (Matthews, 1982). The other members of the genus include Bovine
Papular Stomatitis virus (BPSV), Parapoxvirus of red deer in New Zealand (PVNZ)
and Pseudocowpox virus (PCPV). Furthermore, three tentative …

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.