Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Δευτέρα 2 Απριλίου 2018
Editorial Board
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Table of Contents
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Response to Letter to the Editor regarding “Effects of respiratory training on heart rate variability and baroreflex sensitivity in individuals with chronic spinal cord injury”
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
Author(s): Bonnie E. Legg Ditterline, Sevda C. Asian, David C. Randall, Susan J. Harkema, Camilo Castillo, Alexander V. Ovechkin
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Editors' Selections From This Issue: Volume 99 / Number 4 / April 2018
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Archives of Physical Medicine and Rehabilitation Supplements
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Masthead
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Correction
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Prediction of Falls in Subjects Suffering From Parkinson Disease, Multiple Sclerosis, and Stroke
Publication date: April 2018
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
Author(s): Ettore Beghi, Elisa Gervasoni, Elisabetta Pupillo, Elisa Bianchi, Angelo Montesano, Irene Aprile, Michela Agostini, Marco Rovaris, Davide Cattaneo
ObjectiveTo compare the risk of falls and fall predictors in patients with Parkinson disease (PD), multiple sclerosis (MS), and stroke using the same study design.DesignMulticenter prospective cohort study.SettingInstitutions for physical therapy and rehabilitation.ParticipantsPatients (N=299) with PD (n=94), MS (n=111), and stroke (n=94) seen for rehabilitation.InterventionsNot applicable.Main Outcome MeasuresFunctional scales were applied to investigate balance, disability, daily performance, self-confidence with balance, and social integration. Patients were followed for 6 months. Telephone interviews were organized at 2, 4, and 6 months to record falls and fall-related injuries. Incidence ratios, Kaplan-Meier survival curves, and Cox proportional hazards models were used.ResultsOf the 299 patients enrolled, 259 had complete follow-up. One hundred and twenty-two patients (47.1%) fell at least once; 82 (31.7%) were recurrent fallers and 44 (17.0%) suffered injuries; and 16%, 32%, and 40% fell at 2, 4, and 6 months. Risk of falls was associated with disease type (PD, MS, and stroke in decreasing order) and confidence with balance (Activities-specific Balance Confidence [ABC] scale). Recurrent fallers were 7%, 15%, and 24% at 2, 4, and 6 months. The risk of recurrent falls was associated with disease type, high educational level, and ABC score. Injured fallers were 3%, 8%, and 12% at 2, 4, and 6 months. The only predictor of falls with injuries was disease type (PD).ConclusionsPD, MS, and stroke carry a high risk of falls. Other predictors include perceived balance confidence and high educational level.
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Effects of Respiratory Training on Heart Rate Variability and Baroreflex Sensitivity in Individuals with Chronic Spinal Cord Injury
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
Author(s): Cameron M. Gee, Christopher R. West
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Correction
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Correction
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
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Return to Play After Injuries: A Survey on the Helpfulness of Various Forms of Assistance in the Shared Decision-Making Process in Semiprofessional Athletes in Germany
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
Author(s): Daniel Niederer, Jan Wilke, Lutz Vogt, Winfried Banzer
ObjectiveTo assess how different decision-guiding factors, such as health- and performance-related stakeholders, as well as evidence-based guidelines, support the process-oriented final positive return-to-play (RTP) decision of head coaches responsible for semiprofessional sport teams.DesignCross-sectional survey.SettingTeam sport.ParticipantsA survey consisting of questions on the importance of different decision-guiding factors used when making the RTP decision after injuries was administered to and completed by head coaches (N=238) of semiprofessional players' teams.InterventionsNot applicable.Main Outcome MeasuresWith respect to helpfulness in the RTP decision-making process, the coaches rated both the importance of the opinions of physicians, physiotherapists, strength and conditioning coaches, and the athletes themselves, and the importance of the general and injury-specific RTP guidelines.ResultsOur survey revealed that the head coaches rely on physicians and physiotherapists to a large extent, to the athletes and to themselves to a medium extent, and to strength and conditioning coaches and RTP guidelines to a small but still relevant extent. The coaches' efforts to seek a shared decision-making process in RTP are, hence, partially evident.ConclusionsA multitude of actuators intervene when making the RTP decision. The professionalization of the RTP process in semiprofessional sports includes the athletes themselves, the head coaches, the (external) physicians, the (external) physiotherapists, and the strength and conditioning coaches based on general RTP decision-making models and specific criteria related to injury type, sports type, level, and playing position. The development of awareness and implementation strategies of RTP models should be subject to further research.
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Accuracy of Ultrasonography for the Diagnosis of Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis
Source:Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 4
Author(s): Ana Torres-Costoso, Vicente Martínez-Vizcaíno, Celia Álvarez-Bueno, Asunción Ferri-Morales, Iván Cavero-Redondo
ObjectiveTo evaluate the accuracy of inlet and outlet ultrasonography measurements for the diagnosis of carpal tunnel syndrome (CTS).Data SourcesMEDLINE, EMBASE, the Cochrane Library, and the Web of Science databases were systematically searched from inception to February 2017.Study SelectionObservational studies comparing the diagnostic accuracy of inlet and outlet ultrasonography measurements were selected.Data ExtractionRandom-effects models for the diagnostic odds ratio (dOR) values computed by Moses' constant for a linear model and 95% confidence intervals (CIs) were used to calculate the accuracy of the test. Hierarchical summary receiver operating characteristic curves were used to summarize overall test performance.Data SynthesisTwenty-eight published studies were included in the meta-analysis. The pooled dOR values for the diagnosis of CTS were 31.11 (95% CI, 20.42–47.40) for inlet-level and 16.94 (95% CI, 7.58–37.86) for outlet-level measurements. The 95% confidence region for the point that summarizes overall test performance of the included studies occurred where the cutoffs ranged from 9.0 to 12.6mm2 for inlet-level measurements and from 9.5 to 10.0mm2 for outlet-level measurements.ConclusionsBoth ultrasonography measurements for the diagnosis of CTS showed sufficient accuracy for their use in clinical settings, although the overall accuracy was slightly higher for inlet-level than for outlet-level measurements. The addition of outlet and inlet measurements does not increase the accuracy for the diagnosis. Therefore, the inlet-level ultrasonography measurement appears to be an appropriate method for the diagnosis of CTS.
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A Novel Technique to Create an Arteriovenous Fistula During Total Percutaneous Deep Foot Venous Arterialisation Using an IVUS Guided Catheter
Publication date: Available online 2 April 2018
Source:European Journal of Vascular and Endovascular Surgery
Author(s): Bruno Migliara, Tania F. Cappellari
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Response to “Re. Abdominal Aortic Aneurysm Calcification: Are Biochemical Markers a Missing Piece of the Puzzle?”
Publication date: Available online 2 April 2018
Source:European Journal of Vascular and Endovascular Surgery
Author(s): Mohammed M. Chowdhury, James H.F. Rudd, Patrick A. Coughlin
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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
Publication date: Available online 2 April 2018
Source:Cell Metabolism
Author(s): Camila Rubio-Patiño, Jozef P. Bossowski, Gian Marco De Donatis, Laura Mondragón, Elodie Villa, Lazaro E. Aira, Johanna Chiche, Rana Mhaidly, Cynthia Lebeaupin, Sandrine Marchetti, Konstantinos Voutetakis, Aristotelis Chatziioannou, Florence A. Castelli, Patricia Lamourette, Emeline Chu-Van, François Fenaille, Tony Avril, Thierry Passeron, John B. Patterson, Els Verhoeyen, Béatrice Bailly-Maitre, Eric Chevet, Jean-Ehrland Ricci
Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding mice a low-protein (Low PROT) isocaloric diet but not a low-carbohydrate (Low CHO) diet reduced tumor growth in three independent mouse cancer models. Surprisingly, this effect relies on anticancer immunosurveillance, as depleting CD8+ T cells, antigen-presenting cells (APCs), or using immunodeficient mice prevented the beneficial effect of the diet. Mechanistically, we established that a Low PROT diet induces the unfolded protein response (UPR) in tumor cells through the activation of IRE1α and RIG1 signaling, thereby resulting in cytokine production and mounting an efficient anticancer immune response. Collectively, our data suggest that a Low PROT diet induces an IRE1α-dependent UPR in cancer cells, enhancing a CD8-mediated T cell response against tumors.
Graphical abstract
Teaser
Dietary restriction (DR) slows down tumor growth by increasing tumor immunosurveillance. Rubio-Patiño et al. show that a moderate reduction in dietary protein intake, rather than carbohydrate reduction, without overall calorie changes, activates the IRE1α/RIG1 pathway in tumor cells resulting in an anticancer immune response in mice.https://ift.tt/2JcYB55
Cytomorphological features as predictors of epidermal growth factor receptor mutation status in lung adenocarcinoma
CytoJournal 2018 15(1):11-11
Background: Epidermal growth factor receptor mutation-positive (EGFR-p) lung adenocarcinomas are sensitive to tyrosine kinase inhibitors. Although histopathological subtype is an independent predictor of mutation status, there is a paucity of data on the cytomorphological features correlating with the EGFR mutation status. Therefore, the aim of this study was to determine whether certain cytomorphological features correlate with EGFR mutation in lung adenocarcinoma. Materials and Methods: A retrospective analysis of 48 lung adenocarcinoma cases diagnosed on fine needle aspiration cytology with known EGFR mutation status was conducted. All cytology smears with cellblock sections were reviewed. The cytomorphological features including tumor pattern, stromal features, nuclear and cytoplasmic features, and tumor grade were evaluated. Clinicoradiological features such as age, sex, smoking, tumor size, clinical stage, metastases, and presence of mass, nodule, lymphadenopathy, pleural effusion, and clinical outcome were also assessed. Results: Of 48 cases, 19 were EGFR-p and 29 were negative. EGFR-p cases showed a positive and significant correlation with flat monolayered sheets and acini, mild nuclear atypia, fine chromatin and smooth nuclear margins and these tumors were well differentiated. EGFR-negative tumors were moderate to poorly differentiated with predominance of solid clusters, moderate to marked nuclear atypia, with irregular nuclear margins and coarse chromatin. Clinically, female sex, nonsmoking status, smaller tumor size, and good clinical outcome correlated with EGFR-p status. Conclusion: Certain cytomorphological features correlate with and may suggest EGFR mutation status in advanced lung adenocarcinoma in an appropriate clinical context.
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Fine needle aspiration cytology finding of a parotid mass with chondromyxoid matrix and variable epithelial cytological atypia
CytoJournal 2018 15(1):10-10
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Scholar : These new articles for New Political Science are available online
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Ischemic oculomotor nerve palsy due to hyaluronic acid filler injection
Journal of Cosmetic Dermatology, EarlyView.
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