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Πέμπτη 19 Απριλίου 2018
Scholar : Philosophical Magazine, Volume 98, Issue 17, June 2018 is now available online on Taylor & Francis Online
Scholar : These new articles for The American Journal of Family Therapy are available online
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Scholar : Journal of Natural History, Volume 52, Issue 17-18, May - May 2018 is now available online on Taylor & Francis Online
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Modeling of intracerebral interictal epileptic discharges: Evidence for network interactions
Source:Clinical Neurophysiology, Volume 129, Issue 6
Author(s): Stephan Meesters, Pauly Ossenblok, Albert Colon, Louis Wagner, Olaf Schijns, Paul Boon, Luc Florack, Andrea Fuster
ObjectiveThe interictal epileptic discharges (IEDs) occurring in stereotactic EEG (SEEG) recordings are in general abundant compared to ictal discharges, but difficult to interpret due to complex underlying network interactions. A framework is developed to model these network interactions.MethodsTo identify the synchronized neuronal activity underlying the IEDs, the variation in correlation over time of the SEEG signals is related to the occurrence of IEDs using the general linear model. The interdependency is assessed of the brain areas that reflect highly synchronized neural activity by applying independent component analysis, followed by cluster analysis of the spatial distributions of the independent components. The spatiotemporal interactions of the spike clusters reveal the leading or lagging of brain areas.ResultsThe analysis framework was evaluated for five successfully operated patients, showing that the spike cluster that was related to the MRI-visible brain lesions coincided with the seizure onset zone. The additional value of the framework was demonstrated for two more patients, who were MRI-negative and for whom surgery was not successful.ConclusionsA network approach is promising in case of complex epilepsies.SignificanceAnalysis of IEDs is considered a valuable addition to routine review of SEEG recordings, with the potential to increase the success rate of epilepsy surgery.
https://ift.tt/2qH3Oto
Telomere length, thyroid dysfunction/autoimmunity and parity
Source:Medical Hypotheses, Volume 116
Author(s): Ioannis Ilias, Maria Alexiou, George Mastorakos
There may exist an association between thyroid dysfunction/autoimmunity and parity. Autoimmune thyroiditis shows some degree of telomere shortening. Parity was recently found to be associated with telomere shortening. We hypothesize that among the factors affecting the tentative association between parity and thyroid dysfunction/autoimmunity shortened telomeres' may also be implicated. This could also be another facet of the processes leading to autoimmune thyroiditis.
https://ift.tt/2HaJPhD
Vitamin D deficiency may stimulate fibroblasts in Dupuytreńs disease via mitochondrial increased reactive oxygen species through upregulating transforming growth factor-β1
Source:Medical Hypotheses
Author(s): Harun Seyhan, Jan-Phillip Stromps, Erhan Demir, Paul C. Fuchs, Jürgen Kopp
Dupuytren's disease, a benign fibroproliferative disorder of the palmar fascia, represents an ideal model to study tissue fibrosis. Transforming growth factor-β1 (TGF-β1) and its downstream Smad signaling system is well established as a keyplayer during fibrogenesis. Vitamin D has been extensively studied as an anti-fibrotic agent in malignant chronic diseases. A number of studies have shown that myofibroblasts are main target cells of 1,25(OH)2D3 inhibitory action. The myofibroblast in the palmar aponeurosis of patients in different stages of Dupuytren's disease was found by electron microscopy to contain a large number of mitochondria. Mitochondria play a critical role in cell metabolism being the major source of reactive oxygen species (ROS) in cells. TGF-β1 has been shown to increase mitochondrial ROS production in different cell types, which mediate fibrosis related gene expression and myofibroblast differentiation. TGF-β1 increases mitochondrial ROS production in patients with Dupuytreńs contracture potentially in consequence of Vitamin D deficiency, leading to myofibroblast differentiation. Thus, targeting this basic pathomechanism seems suitable to establish new treatment strategies.
https://ift.tt/2qK5134
Neuromuscular taping reduces blood pressure in systemic arterial hypertension
Source:Medical Hypotheses
Author(s): M. Shah, P.O.O. Julu, J.A. Monro, J. Coutinho, C. Ijeh, B.K. Puri
Systemic arterial hypertension, a well-known cause of morbidity, is associated with dysfunction of the autonomic nervous system. Neuromuscular taping (also known as kinesio taping, medical taping and Vendje neuromuscular) allows movement and muscle activity to treat pain, muscle disorders and lymphoedema, in which its mode of action may involve muscular stimulation leading to increased local blood circulation or stimulating dermatological, muscular and fascial structures with a form of passive massage. We hypothesised that neuromuscular taping may reduce blood pressure in systemic arterial hypertension. This hypothesis was tested by carrying out the first pilot study of its kind to determine whether the non-invasive technique of neuromuscular taping can reduce blood pressure in patients suffering from systemic arterial hypertension. Neuromuscular taping was symmetrically applied to the back, between C1 and T2, of seven hypertensive patients for 5-7 days. Cardiovascular autonomic parameters were assessed at baseline and at the end of the study. Taping was associated with falls in mean arterial blood pressure (p=0.001), mean systolic blood pressure (p<0.01), mean diastolic pressure (p<0.01) and cardiac vagal tone at rest (p=0.063). The beneficial effects on blood pressure appeared to last for at least five days post-neuromuscular taping. There is an indication, given the reduction in cardiac vagal tone at rest, that the mechanism of action of this intervention involves modulation of the brainstem parasympathetic system during cardiovascular control. Further studies are indicated to replicate the present findings, further investigate the effects of taping on autonomic functioning, and establish the optimum time-period and taping positioning.
https://ift.tt/2HcmEDZ
The electronics in fluorescent bulbs and light emitting diodes (LED), rather than ultraviolet radiation, cause increased malignant melanoma incidence in indoor office workers and tanning bed users
Source:Medical Hypotheses
Author(s): Samuel Milham, Dave Stetzer
The epidemiology of cutaneous malignant melanoma (CMM) has a number of facets that don't fit with sunlight and ultraviolet light as the primary etiologic agents. Indoor workers have higher incidence and mortality rates of CMM than outdoor workers; CMM occurs in body locations never exposed to sunlight; CMM incidence is increasing in spite of use of UV blocking agents and small changes in solar radiation.Installation of two new fluorescent lights in the milking parlor holding area of a Minnesota dairy farm in 2015 caused an immediate drop in milk production. This lead to measurement of body amperage in humans exposed to modern non-incandescent lighting. People exposed to old and new fluorescent lights, light emitting diodes (LED) and compact fluorescent lights (CFL) had body amperage levels above those considered carcinogenic. We hypothesize that modern electric lighting is a significant health hazard, a carcinogen, and is causing increasing CMM incidence in indoor office workers and tanning bed users. These lights generate dirty electricity (high frequency voltage transients), radio frequency (RF) radiation, and increase body amperage, all of which have been shown to be carcinogenic. This could explain the failure of ultraviolet blockers to stem the malignant melanoma pandemic. Tanning beds and non-incandescent lighting could be made safe by incorporating a grounded Faraday cage which allows passage of ultraviolet and visible light frequencies and blocks other frequencies. Modern electric lighting should be fabricated to be electrically clean.
https://ift.tt/2qJLTlT
Upregulated epithelial junction expression represents a novel parameter of the epithelial radiation response to fractionated irradiation in oral mucosa
Abstract
Purpose
During head and neck cancer treatment, the radiation response of the oral mucosa represents a frequent early side effect. Besides radiation-induced inhibition of proliferation, various other cellular responses occur. The radiation response of adherens and tight junction proteins was so far mostly investigated with large single-dose irradiation protocols, in vivo and in vitro. Therefore, the current study was initiated to investigate the impact of daily fractionated irradiation on the expression of adherens and tight junction proteins in vivo.
Materials and methods
Fractionation with 5 × 3 Gy/week (days 0–4, 7–11) was given to the snouts of mice. Groups of 5 animals per day were euthanized every second day between day 0 (unirradiated controls) and day 14, and their tongues subjected to histological processing. Adherens junction marker (β-catenin and E‑cadherin) and tight junction marker (claudin-1 and occludin) expression was analysed in the oral mucosa of unirradiated controls and during two weeks of fractionated irradiation.
Results
Adherens as well as tight junction marker proteins were rapidly and consistently upregulated in both the germinal as well as the functional layer of the oral mucosa. This represents a previously unknown parameter of the epithelial radiation response to clinically relevant fractionation protocols.
Conclusion
Fractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a new parameter of the epithelial radiation response to fractionated irradiation.
https://ift.tt/2qIysmR
Scholar : These new articles for Norwegian Archaeological Review are available online
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Scholar : These new articles for Text and Performance Quarterly are available online
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Variation in accumulation, transport, and distribution of phthalic acid esters (PAEs) in soil columns grown with low- and high-PAE accumulating rice cultivars
Abstract
The extensive use of plasticizers containing di-n-butyl phthalate (DBP) and di-(2-ethylhexyl) phthalate (DEHP) results in high residual concentrations in agricultural soils and poses potential risks to human health through the food chain. Here, two rice cultivars with low (Fengyousimiao) and high (Peizataifeng) phthalic acid ester (PAE) accumulation were grown in leaching columns packed with DBP- and DEHP-contaminated soils to investigate their transport, fraction distribution, and accumulation in soil-rice-water system. Significant differences in soil vertical distribution of DBP and DEHP were observed among the two cultivars, sterilization and non-sterilization treatments. Both DBP and DEHP could leach to the bottom layer even though their concentrations in both soil and pore water decreased along with soil depth. DBP and DEHP concentrations in pore water were significantly correlated with those in corresponding soil layer at ripening stage. The available fractions including desorbing and non-desorbing fractions were predominant in the total concentrations of DBP and DEHP of soils. DBP and DEHP storages in coarse soil fractions (i.e., coarse and fine sands) with higher bioavailability displayed higher bioconcentration factors compared to finer soil fractions (i.e., silt and clay), and bioconcentration factors of Peizataifeng were higher than those of Fengyousimiao. The variations in vertical migration and accumulation of DBP and DEHP by the two cultivars implied different adverse effects on the security of groundwater and food.
https://ift.tt/2J9wrHo
Scholar : ΠΑΡΕΣΗ BELL - νέα αποτελέσματα
[PDF] Hyperbaric oxygen therapy: its use in medical emergencies and its development in Hong Kong
incomplete or complete spinal cord paresis, or severe vestibular dysfunction. Diagnosis
of DCI is primarily based on clinical findings. Clinicians should be aware of the …
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[HTML] Dr Edward Tobinick Etanercept vs Strokes
left with a severe residual gait disturbance and severe paresis of the left upper extremity.
Initially … full. Bell's phenomena deviated to the right. There …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
Scholar : Undersea "Hyperbaric Medicine" - νέα αποτελέσματα
[PDF] Hyperbaric oxygen therapy: its use in medical emergencies and its development in Hong Kong
has emerged … Indications for hyperbaric oxygen therapy approved by the
Undersea and Hyperbaric Medical Society2 … When a diver ascends following …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
Scholar : Obstructive sleep apnea - νέα αποτελέσματα
Oral Interventions for Obstructive Sleep Apnea.
and maxillomandibular advancement (MMA) in the treatment of children and adults
with obstructive sleep apnea (OSA) has not yet been adequately assessed. An …
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[PDF] Airway findings of nasolaryngoscopy and cephalometry associated with obstructive sleep apnea
upper airway. The objectives of the current study were to determine the correlation
between the findings of the fiberoptic nasolaryngoscopy and lateral cephalometry …
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Automatic apnea-hypopnea events detection using an alternative sensor
apneic events happen. In comparison, data with no events shows clear
breathing in channels from the thorax and the abdomen and consequently …
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The influential factors on the morphological changes of upper airway associated with mouth opening
apneas and hypopneas … OSAHS patients.3 One theory argued the habitual
MO during sleep might not … The pharyngeal airway still suffered elevated …
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Neonatal Onset Interstitial Lung Disease as a Primary Presenting Manifestation of Mucopolysaccharidosis Type I
(ERT) which has demonstrated promising improvements in 6-min walk
distance, pulmonary function testing metrics, and apnea–hypopnea indices …
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Age-Associated Changes in Structure and Function of the Aging Human Lung
chronic obstructive pulmonary disease (COPD) that usually occurs in the sixth decade
of life and beyond (Barnes, 2000). Even in the absence …
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[HTML] Assessment of sleep quality using cardiopulmonary coupling analysis in patients with Parkinson's disease
obstructive pulmonary among … vari- ables are recorded: 1) HFC, 2) LFC,
3) VLFC, 4) The apnea- hypopnea index (AHI), which determines the number …
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[HTML] A Mini Review of Using the Oralift Appliance and a Pilot Study to See if 3D Imaging Techniques Could Improve Outcomes
sleep apnea: A review … It could be said that the Oralift ® appliance wakes
up the sleeping DNA and … R, Rogers R, Schmidt-Nowara W. Oral appliances …
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[PDF] Melanoma in an obese diabetic adolescent
major risk factors for chronic non-communicable diseases, such as
hypertension, dyslipidemia, insulin resistance/Type 2 diabetes mellitus …
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Postoperative outcomes of esophagectomy for cancer in elderly patients
insufficiency (585-585.9), coronary artery disease (414-414.9), peripheral vascular disease
(443-443.9), chronic obstructive pulmonary disease (491-492.8), and sleep apnea (327.23) …
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
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Publication date: September 2017 Source: Free Radical Biology and Medicine, Volume 110 Author(s): Lucía Fernández-del-Río, Anish Nag, Elen...
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Abstract Noise pollution is a major factor of environmental complaints in many cities, which has significant impacts on human health. As a...
