New observations regarding Helicobacter pylori and gastric cancer in Mongolia

Helicobacter, EarlyView.


https://ift.tt/2l6iTCi

Socio-economic factors influencing farmers’ willingness to undertake environmental responsibility

Abstract

Acknowledging the importance of water resources protection and sustainable management, the European Parliament enacted directives based on the "polluter-pays" principle aiming for "environmental damage" protection and restoration of water resources. The main aim of this paper is to examine, for the first time in Greece, the possibility of achieving environmental goals, such as reduction of agrochemical pollution and irrigation water use, alongside with the farmers' willingness to undertake the environmental costs arising from their activity. In a questionnaire survey, conducted using a "state preference" method, participants were asked to respond on whether they are willing to absorb an "environmental charge" for the protection and restoration of surface and ground water. It is an essential precondition to understand the factors that affect taxpayers' willingness to participate in the Water Framework Directive, as they are expected to cover the cost of its implementation. The identification of the driving forces that affect stakeholders' environmental decisions can emerge as an important and useful tool in extending public participation in the Water Framework Directive.

https://ift.tt/2sRVsRL

Spatial distribution and ecological risk assessment of sediment metals in a highly industrialized coastal zone southwestern Taiwan

Abstract

Spatial variations of Cr, Cu, Hg, Ni, Pb, and Zn in the surface sediments from 34 stations of the Kaohsiung coastal zone southwestern Taiwan were studied to address the current pollution status, sediment quality, and potential ecological risk. The study revealed that the concentrations of sediment metals in Kaohsiung Harbor were alarmingly high compared to the other region of Kaohsiung coast. The concentrations of Cr, Cu, Hg, Ni, Pb, and Zn in the harbor sediments were as high as 351, 247, 1.93, 61.8, 60.9, and 940 mg kg⁻¹, respectively. The current situation of metal pollution was assessed by different pollution indices and results showed moderate to severe enrichment of Cu, Hg, and Zn in the harbor sediments. According to the degree of contamination, pollution load index, and contamination severity index, the sediments from the inner Kaohsiung Harbor show high degree and high severity of metal contamination, while the rest of Kaohsiung coastal areas show uncontaminated or low-level pollution. Results of mean ERM quotient and potential ecological risk index also indicated that the harbor sediments posed a 49% probability of biological toxicity and very high ecological risk. The toxic units indicated that the negative biological effects of the six metals in the harbor sediments were Zn > Cu > Cr > Ni > Hg > Pb. In contrast to Kaohsiung Harbor as a trap where considerable amount of anthropogenic metal loadings accumulated in sediments, low metal concentrations were observed in most Kaohsiung coastal sediments. It probably resulted from the limited fine-grained sediment deposition. In the wave-dominated Kaohsiung coastal zone, fine-grained sediments associated with polluted metals tend to be easily resuspended and transported offshore via waves and wave-induced currents. The results of this study can provide valuable information for river and coastal zone management.

https://ift.tt/2LLtduG

Antiangiogenic therapy: markers of response, “normalization” and resistance

Publication date: Available online 12 June 2018
Source:Critical Reviews in Oncology/Hematology
Author(s): Karima El Alaoui-Lasmaili, Béatrice Faivre
Currently in cancer treatment, one premise is to use antiangiogenic therapies in association with chemotherapy or radiotherapy to augment their efficacy by benefiting from the vascular "normalization" induced by antiangiogenic therapy. This concept defines the time during which the tumor blood vessels adopt normal-like morphology and functionality, i.e. the blood vessels become more mature, the perfusion augments and hypoxia decreases. To date, there is such a diversity of treatment protocols where the type of antiangiogenic to adopt, its dose and duration of administration are different, that knowing when and how to treat is problematic. In this review, we analyzed thoroughly preclinical and clinical studies that use antiangiogenic treatments to benefit from the "normalization" and showed that the effects depend on the type of antiangiogenic administrated (anti-VEGF, anti-VEGFR, Multi-Kinase Inhibitor) and on the duration of treatment. Finally, biomarkers of "normalization" and resistance that could be used in the clinic are presented.



https://ift.tt/2JvGOtr

Scleroderma‐like skin changes induced by checkpoint inhibitor therapy

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2l30yWW

Distinguishing between irritated seborrheic keratosis and squamous cell carcinoma in situ using BCL‐2 and IMP3 immunohistochemistry

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2y4GhcP

Atypical cellular neurothekeoma: A potential diagnostic pitfall for benign and malignant spindle cell lesions in skin

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2l3Vt0s

The difficulty in interpreting gene expression profiling in BAP‐negative melanocytic tumors

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2t1p9yQ

A first for dermatopathology and pathology in general: Appropriate use criteria in dermatopathology from the American Society of Dermatopathology

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2l6iyzO

Adenodermatofibroma possessing dilated glandular structures with eccrine features: A case study

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2t3qsxc

Primary cutaneous vascular leiomyosarcoma: A rare subtype of leiomyosarcoma of the skin

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2l3ynqH

Appropriate use criteria in dermatopathology: Initial recommendations from the American Society of Dermatopathology

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2y359ll

Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2l3ynab

Deceptively bland cutaneous angiosarcoma on the nose mimicking hemangioma—A clinicopathologic and immunohistochemical analysis

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2t2CTtn

Desvenlafaxine versus Venlafaxine for the Treatment of Adult Patients with Major Depressive Disorder: A Review of the Comparative Clinical and Cost-Effectiveness [Internet].

The purpose of this report is to examine the clinical effectiveness and cost-effectiveness of desvenlafaxine compared to venlafaxine for the treatment of adults patients with Major Depressive Disorder (MDD).

https://ift.tt/2l3PRTW

The potential of alternatives to face-to-face consultation in general practice, and the impact on different patient groups: a mixed-methods case study.

This study showed a low uptake of alternatives, lack of clarity about their purpose and potential for benefit but little evidence at present

https://ift.tt/2ybXnFU

Exploring Equity in Multisector Community Health Partnerships: Proceedings of a Workshop.

Building on previous National Academies of Sciences, Engineering, and Medicine workshops that explored how safe and healthy communities are a necessary component of health equity and efforts to improve population health, the Roundtable on Population Health Improvement wanted to explore how a variety of community-based organizations came together to achieve population health. To do so, the roundtable hosted a workshop in Oakland, California, on December 8, 2016, to explore multisector health partnerships that engage residents, reduce health disparities, and improve health and well-being. This publication summarizes the presentations and discussions from the workshop.

https://ift.tt/2l395sR

Protecting the Health and Well-Being of Communities in a Changing Climate: Proceedings of a Workshop.

On March 13, 2017, the Roundtable on Environmental Health Sciences, Research, and Medicine and the Roundtable on Population Health Improvement jointly convened a 1-day public workshop in Washington, DC, to explore potential strategies for public health, environmental health, health care, and related stakeholders to help communities and regions to address and mitigate the health effects of climate change. Participants discussed the perspectives of civic, government, business, and health-sector leaders, and existing research, best practices, and examples that inform stakeholders and practitioners on approaches to support mitigation of and adaptation to climate change and its effects on population health. This publication summarizes the presentations and discussions from the workshop.

https://ift.tt/2t8P4VB

Public Health Consequences of E-Cigarettes.

Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes.

https://ift.tt/2l394VP

Urbanization and Slums: Infectious Diseases in the Built Environment: Proceedings of a Workshop.

The urban built environment is a prime setting for microbial transmission, because just as cities serve as hubs for migration and international travel, components of the urban built environment serve as hubs that drive the transmission of infectious disease pathogens. The risk of infectious diseases for many people living in slums is further compounded by their poverty and their surrounding physical and social environment, which is often overcrowded, is prone to physical hazards, and lacks adequate or secure housing and basic infrastructure, including water, sanitation, or hygiene services.

https://ift.tt/2t3UukB