Langerhans Cell Histiocytosis With Clinical and Histologic Features of Hidradenitis Suppurativa: Brief Report and Review

Abstract: Langerhans cell histiocytosis (LCH) is an uncommon histiocytic disorder in adults. Clinically, this rare entity can mimic other dermatologic conditions, including hidradenitis suppurativa. A case of LCH is reported with clinical and histologic features of hidradenitis suppurativa, along with a review of these unusual findings. Clinical dermatologists and dermatopathologists benefit from awareness of this unique presentation, which may prompt earlier identification and diagnosis of adult patients with LCH.

https://ift.tt/2K3TIv5

ALK Rearrangements Are Infrequent in Cellular Blue Nevus and Deep Penetrating Nevus

Abstract: Recent studies have identified kinase fusions in Spitzoid melanocytic neoplasms, and approximately 10% of Spitzoid neoplasms harbor anaplastic lymphoma kinase (ALK) rearrangements and corresponding ALK immunoreactivity. Deep penetrating nevi (DPN), a subset of melanocytic neoplasms, have histologic and immunohistochemical overlap that have historically supported classification of DPN with blue/cellular blue nevi (CBN). However, HRAS mutations have rarely been detected in DPN, thereby also linking them to Spitz nevi. The purpose of this study was to see if DPN or CBN possess ALK rearrangements, thereby providing more evidence that these melanocytic lesions may be pathogenetically related to Spitzoid neoplasms. Using ALK immunohistochemistry as a surrogate for ALK rearrangement, the authors examined 26 DPN, 30 CBN, and 4 conventional blue nevi. ALK immunoreactive cases underwent fluorescent in situ hybridization to investigate for the presence of ALK gene rearrangement. Patchy and focal ALK immunostaining was found in only 1 case of DPN (1/26, 3.8%). Seven cases of CBN (7/30; 23%) showed ALK immunostaining (6 focal/patchy, 1 strong and diffuse). Fluorescent in situ hybridization using ALK break-apart probes showed various degrees of gain of 2p23 and rare ALK break-apart signals. Four CBN showed ALK rearrangement in 2%–4% of cells. Two cases of CBN showed gain of 2p23 in 10%–20% of cells. In our study, ALK rearrangements are uncommon in both CBN and DPN, making ALK an unlikely driver in tumorigenesis and classification of these melanocytic variants. However, our study did identify ALK molecular changes and immunohistochemical staining patterns that have not been previously described in CBN or DPN.

https://ift.tt/2JUHWqL

Acquisition of Somatic NRAS Mutations in Central Nervous System Melanocytes: A Predisposing Risk Factor to Primary Melanoma of the Central Nervous System, a Frequently Forgotten Pitfall in Congenital Nevi

Abstract: Congenital melanocytic nevi (CMN) are benign melanocytic proliferations that are usually present at birth. A somatic mosaicism for an NRAS point mutation is responsible for the several phenotypic abnormalities that may be associated with congenital nevi. We report the case of a 7-year-old boy with a proliferative nodule (PN) arising in a Giant CMN completely excised and with several visceral and intraspinal melanoma metastases with no evidence of primary cutaneous melanoma. The careful analysis of the clinical, morphologic, and molecular features allowed the distinction of between the benign PN (BPN) and the melanoma. The BPN showed a characteristic comparative genomic hybridization pattern with gains or losses of whole chromosomes, whereas the melanoma displayed gains or losses involving complex partial chromosomal copy number gains or losses. Leptomeningeal melanocytes are more susceptible to transformation by oncogenic NRAS than cutaneous melanocytes, and central nervous system melanomas are more common than cutaneous melanomas in the setting of CMN. Thus, it has been recommended to characterize the congenital disease in patients with 2 CMN at birth, independently of size and site, with a single magnetic resonance imaging screening younger than the age of 1 year.

https://ift.tt/2K4EQN9

Volar Papulonodules in a Patient With Seronegative Rheumatoid Arthritis: Answer

No abstract available

https://ift.tt/2JXmkdp

Psoriasiform Graft-Versus-Host Disease: Report and Brief Review of the Literature

Abstract: Graft-versus-host disease (GVHD) is the primary cause of morbidity and non–relapse-related mortality after hematopoietic stem cell transplantation. GVHD is classically divided into acute and chronic forms; acute cutaneous GVHD presents as a morbilliform eruption, whereas chronic cutaneous GVHD presents with lichen planus–like or sclerodermoid morphology. Psoriasiform GVHD is a rarely described subtype that is challenging to distinguish clinically from psoriasis. In addition to classic psoriasiform histologic findings, demonstration of an often subtle vacuolar interface dermatitis and lymphocyte satellitosis are helpful for discrimination. Herein, the authors describe psoriasiform GVHD and review the clinicopathologic findings of this unusual variant. With the appropriate clinical findings, psoriasiform GVHD should be considered in the histologic differential diagnosis of a mixed tissue reaction pattern with both psoriasiform and interface changes.

https://ift.tt/2MaOOwZ

An Indurated Plaque in a Toddler: Answer

No abstract available

https://ift.tt/2MKgASj

Unusual Case of Combined Gliomeningeal Heterotopia on the Nose of an Infant

Abstract: Nasal glial heterotopia ("nasal glioma") and cutaneous heterotopic meningeal nodules ("primary cutaneous meningioma") are rare congenital lesions characterized by the presence of heterotopic mature cerebral tissues. Nasal glial heterotopia occurs predominantly in the nasal area and typically does not contain meningothelial elements, whereas heterotopic meningeal nodules occur predominantly on the scalp and do not contain glial elements. In this article, we report an unusual case of cutaneous heterotopia on the nose of an infant composed of both glial and meningothelial elements. The glial component was characterized by irregular islands of predominantly astrocytic cells, on a fibrillary background. The meningothelial component was characterized by bland ovoid cells with focal intranuclear inclusions forming whorled arrangements, with associated psammomatous calcification. To our knowledge, this is the first time such a lesion has been documented. It has also provided us with an opportunity to review the literature regarding heterotopic deposits of both glial and meningothelial tissues.

https://ift.tt/2K7gIt1

Utility of Examining Deeper Levels and/or Special Stains

No abstract available

https://ift.tt/2JV5NqA

A Case of ALK+ Anaplastic Large-Cell Lymphoma With Aberrant Myeloperoxidase Expression and Initial Cutaneous Presentation

Abstract: Anaplastic large-cell lymphoma (ALCL) was first described in 1985 by Stein et al and is a clinically, morphologically, and immunophenotypically heterogeneous neoplasm characterized by ALK expression, rearrangement of the ALK gene, and most characteristically its occurrence in children. Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma. Systemic ALK+ ALCL represents 10%–15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease. Here, we describe a case of a 9-year-old girl who presented with a solitary ulcerated nodule on the elbow that clinically resembled a pyogenic granuloma yet showed ALK, CD30, and myeloperoxidase expression. Fluorescent in situ hybridization with a break-apart probe for ALK revealed the presence of an ALK gene rearrangement. The initial workup showed no evidence of extracutaneous malignancy, and a diagnosis of primary cutaneous ALK+ ALCL was favored. Subsequent imaging studies revealed mediastinal lymphadenopathy, compatible with a systemic form of T-cell lymphoma, treated subsequently with chemotherapy. This report highlights the importance of an adequate systemic evaluation on the presentation of a cutaneous form of ALK+ ALCL.

https://ift.tt/2JZXO7s

Volar Papulonodules in a Patient With Seronegative Rheumatoid Arthritis: Challenge

No abstract available

https://ift.tt/2MJVpQa

T-pattern detection and analysis for the discovery of hidden features of behaviour

Publication date: Available online 20 June 2018
Source:Journal of Neuroscience Methods
Author(s): M. Casarrubea, M.S. Magnusson, M.T. Anguera, G.K. Jonsson, M. Castañer, A. Santangelo, M. Palacino, S. Aiello, F. Faulisi, G. Raso, S. Puigarnau, O. Camerino, G. Di Giovanni, G. Crescimanno
BackgroundThe behaviour of all living beings consists of hidden patterns in time; consequently, its nature and its underlying dynamics are intrinsically difficult to be perceived and detected by the unaided observer.MethodSuch a scientific challenge calls for improved means of detection, data handling and analysis. By using a powerful and versatile technique known as T-pattern detection and analysis (TPA) it is possible to unveil hidden relationships among the behavioural events in time.ResultsTPA is demonstrated to be a solid and versatile tool to study the deep structure of behaviour in different experimental contexts, both in human and non human subjects.ConclusionThis review deepens and extends contents recently published by adding new concepts and examples concerning the applications of TPA in the study of behaviour both in human and non-human subjects



https://ift.tt/2M6m48G

Refinement of embolic stroke model in rats: effect of post-embolization anesthesia duration on arterial blood pressure, cerebral edema and mortality

Publication date: Available online 20 June 2018
Source:Journal of Neuroscience Methods
Author(s): Bryan T.C. Chuang, Xiaoguang Liu, Alexander J. Lundberg, Tommy J.K. Toung, John A. Ulatowski, Raymond C. Koehler
BackgroundInjection of a clot into the internal carotid artery is an experimental model of ischemic stroke that is considered to closely mimic embolic stroke in humans. In this model, the common carotid artery typically remains temporarily occluded to permit time for stabilization of the clot in the middle cerebral artery. However, the associated lengthening of the anesthesia duration could affect arterial blood pressure and stroke outcome.New methodWe refined the model by examining how increasing isoflurane anesthesia duration from 30 to 60 min after clot embolization affects mortality, infarct volume, edema, blood-brain barrier permeability, and the 8-h post-ischemic time course of blood pressure, which has not been reported previously in this model.ResultsWe found that arterial pressure increased after discontinuing anesthesia in both embolized groups and that the increase was greater than in the corresponding non-embolized sham-operated rats. At 24 h, the group with 60-min post-ischemia anesthesia exhibited greater brain water content and a greater ipsilateral-to-contralateral ratio of extravasated Evans blue dye. Mortality was greater in the 60-min group, but infarct volume among survivors was not different from that in the 30-min anesthesia group.Comparison with existing methodsThis study refines the embolic stroke model by demonstrating the importance of minimizing the duration of anesthesia after embolization.ConclusionsThese data indicate that early discontinuation of isoflurane anesthesia after clot embolization permits an earlier hypertensive response that limits edema formation and mortality without significantly affecting infarct volume in survivors, thereby decreasing the required number of animals.



https://ift.tt/2JSU9MW

Central neuropathic pain in paraplegia alters movement related potentials

Publication date: August 2018
Source:Clinical Neurophysiology, Volume 129, Issue 8
Author(s): Aleksandra Vučković, Mohammed Jarjees, Muhammad Abul Hasan, Makoto Miyakoshi, Matthew Fraser
ObjectivesSpinal Cord Injured (SCI) persons with and without Central Neuropathic Pain (CNP) show different oscillatory brain activities during imagination of movement. This study investigates whether they also show differences in movement related cortical potentials (MRCP).MethodsSCI paraplegic patients with no CNP (n = 8), with CNP in their lower limbs (n = 8), and healthy control subjects (n = 10) took part in the study. EEG clustering involved independent component analysis, equivalent current dipole fitting, and Measure Projection to define cortical domains that have functional modularity during the motor imagery task.ResultsThree domains were identified: limbic system, sensory-motor cortex and visual cortex. The MRCP difference between the groups of SCI with and without CNP was reflected in a domain located in the limbic system, while the difference between SCI patients and control subjects was in the sensorimotor domain. Differences in MRCP morphology between patients and healthy controls were visible for both paralysed and non paralysed limbs.ConclusionSCI but not CNP affects the movement preparation, and both SCI and CNP affect sensory processes.SignificanceRehabilitation strategies of SCI patients based on MRCP should take into account the presence of CNP.



https://ift.tt/2MFAlds

Scholar : These new articles for Advances in Mental Health are available online

The online platform for Taylor & Francis Online content New for Advances in Mental Health and online now on Taylor & Francis Online: Original Articles Transitional supported housing for mental health consumers enabling personal recovery: Allowing me to be me Kate P Dorozenko, Sue Gillieatt, Robyn Martin, Ben Milbourn & Kim Jennings Pages: 1-12 | DOI: 10.1080/18387357.2018.1480396 The acceptability of a single session family focused approach for children/young people and their parents attending a child and youth mental health service Benjamin Hoadley, Adrian Falkov & Neelya Agalawatta Pages: 1-11 | DOI: 10.1080/18387357.2018.1480398 2018 Future Directions Forum JOIN US at the 2018 Future Directions Forum for Journal of Clinical Child & Adolescent Psychology - June 15-16, 2018 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Tweeting about measles during stages of an outbreak: A semantic network approach to the framing of an emerging infectious disease

Publication date: Available online 19 June 2018
Source:American Journal of Infection Control
Author(s): Lu Tang, Bijie Bie, Degui Zhi
BackgroundThe public increasingly uses social media not only to look for information about emerging infectious diseases (EIDs), but also to share opinions, emotions, and coping strategies. Identifying the frames used in social media discussion about EIDs will allow public health agencies to assess public opinions and sentiments.MethodThis study examined how the public discussed measles during the measles outbreak in the United States during early 2015 that originated in Disneyland Park in Anaheim, CA, through a semantic network analysis of the content of around 1 million tweets using KH coder.ResultsFour frames were identified based on word frequencies and co-occurrence: news update, public health, vaccination, and political. The prominence of each individual frame changed over the corse of the pre-crisis, initial, maintenance, and resolution stages of the outbreak.ConclusionsThis study proposed and tested a method for assessing the frames used in social media discussions about EIDs based on the creation, interpretation, and quantification of semantic networks. Public health agencies could use social media outlets, such as Twitter, to assess how the public makes sense of an EID outbreak and to create adaptive messages in communicating with the public during different stages of the crisis.



https://ift.tt/2MJevGb

Association of human beta‐defensin 1 gene polymorphisms with nonsegmental vitiligo

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KaDC6b

Aciclovir for treatment of pityriasis lichenoides?

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2K2tysI

Actinic Keratosis Area Severity Index (AKASI): reproducibility study and comparison with total lesion count

British Journal of Dermatology, EarlyView.


https://ift.tt/2K3sMyZ

Herpetiform pemphigus with characteristic transmission electron microscopic findings of various‐sized ballooning vacuoles in keratinocytes without acantholysis

British Journal of Dermatology, EarlyView.


https://ift.tt/2I7ynz4

Clinical and dermoscopic features of Spitz naevus by sex, age and anatomical site: a study of 913 Spitz naevi

British Journal of Dermatology, EarlyView.


https://ift.tt/2K7KUrm